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Recurrence cholangiocarcinoma

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https://www.readbyqxmd.com/read/29681563/prothrombin-complex-concentrate-and-fatal-thrombotic-adverse-events-a-complication-to-keep-in-mind
#1
Rabih Tabet, Youssef Shammaa, Boutros Karam, Harout Yacoub, James Lafferty
Thromboembolic events such as deep vein thrombosis and pulmonary embolism are well-known complications that can occur after prothrombin complex concentrate therapy. However, acute myocardial infarction is a very rare but potentially life-threatening complication that was exclusively described in patients with bleeding disorders who received chronic and recurrent concentrate infusions. We report the case of a 70 year-old male patient with cholangiocarcinoma who was admitted to our hospital with worsening fatigue and weakness...
April 23, 2018: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/29650855/-a-case-of-double-cancer-of-intrahepatic-cholangiocarcinoma-and-gastric-carcinoma-with-difficult-diagnosis-of-the-primary-tumor-with-peritoneal-metastasis
#2
Hiroyuki Kanomata, Yasuji Seyama, Hiroki Kudo, Toru Tanizawa, Masahiro Warabi, Masamichi Takahashi, Yujiro Matsuoka, Ikuo Wada, Masayuki Takegami, Yukio Miyamoto, Nobutaka Umekita
Double cancer of intrahepatic cholangiocarcinoma and gastric cancer is rare. A 62-year-old man underwent gastrectomy for gastric cancer. The pathological findings were tub1>tub2, m, ly0, v0, n0, Stage I A. Two years and a month later, a liver tumor(diameter of 3 cm)and a pelvic mass(diameter of 2.5 cm)were observed. Metastasis from gastric cancer was suspected and chemotherapy(SOX)was administered. However, after 5 courses, CT revealed worseningof the liver tumor (diameter of 12 cm)and pelvic mass(diameter of 3 cm)...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29622700/hybrid-capture-based-tumor-sequencing-and-copy-number-analysis-to-confirm-origin-of-metachronous-metastases-in-brca1-mutant-cholangiocarcinoma-harboring-a-novel-ywhaz-braf-fusion
#3
Huat C Lim, Meagan Montesion, Thomas Botton, Eric A Collisson, Sarah E Umetsu, Spencer C Behr, John D Gordan, Phil J Stephens, Robin K Kelley
Biliary tract cancers such as cholangiocarcinoma represent a heterogeneous group of cancers that can be difficult to diagnose. Recent comprehensive genomic analyses in large cholangiocarcinoma cohorts have defined important molecular subgroups within cholangiocarcinoma that may relate to anatomic location and etiology [1-4] and may predict responsiveness to targeted therapies in development [5-7]. These emerging data highlight the potential for tumor genomics to inform diagnosis and treatment options in this challenging tumor type...
April 5, 2018: Oncologist
https://www.readbyqxmd.com/read/29619266/intrahepatic-sarcomatous-cholangiocarcinoma-case-report-and-review-of-the-literature
#4
Thana Boonsinsukh, Vichit Viriyaroj, Thammanij Rookkachart, Therdkiat Trongwongsa
The authors report a case of a patient with intrahepatic sarcomatous cholangiocarcinoma. A 45-year-old Thai man presented with a 3-month history of right upper abdominal pain. CT scan revealed hepatomegaly with a 6.5 cm hypovascular soft tissue density mass in the right lobe and showed mild delayed enhancement. On exploratory laparotomy, the tumor adherent to right diaphragm was found. We performed right hepatectomy, partial resection of right diaphragm, and cholecystectomy. The immunohistological results suggested "sarcomatous intrahepatic cholangiocarcinoma...
2018: Case Reports in Surgery
https://www.readbyqxmd.com/read/29599608/intraoperative-frozen-section-diagnosis-of-bile-duct-margin-for-extrahepatic-cholangiocarcinoma
#5
Takayuki Shiraki, Hajime Kuroda, Atsuko Takada, Yoshimasa Nakazato, Keiichi Kubota, Yasuo Imai
AIM: To evaluate the usefulness of frozen section diagnosis (FSD) of bile duct margins during surgery for extrahepatic cholangiocarcinoma (CCA). METHODS: We retrospectively analyzed 74 consecutive patients who underwent surgery for extrahepatic CCA from 2012 to 2017, during which FSD of bile duct margins was performed. They consisted of 40 distant and 34 perihilar CCAs (45 and 55 bile duct margins, respectively). The diagnosis was classified into three categories: negative, borderline (biliary intraepithelial neoplasia-1 and 2, and indefinite for neoplasia), or positive...
March 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29588543/urinary-ce-ms-peptide-marker-pattern-for-detection-of-solid-tumors
#6
Iwona Belczacka, Agnieszka Latosinska, Justyna Siwy, Jochen Metzger, Axel S Merseburger, Harald Mischak, Antonia Vlahou, Maria Frantzi, Vera Jankowski
Urinary profiling datasets, previously acquired by capillary electrophoresis coupled to mass-spectrometry were investigated to identify a general urinary marker pattern for detection of solid tumors by targeting common systemic events associated with tumor-related inflammation. A total of 2,055 urinary profiles were analyzed, derived from a) a cancer group of patients (n = 969) with bladder, prostate, and pancreatic cancers, renal cell carcinoma, and cholangiocarcinoma and b) a control group of patients with benign diseases (n = 556), inflammatory diseases (n = 199) and healthy individuals (n = 331)...
March 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29573187/propensity-matched-analysis-of-patients-with-mixed-hepatocellular-cholangiocarcinoma-and-hepatocellular-carcinoma-undergoing-liver-transplantation
#7
Keri E Lunsford, Colin Court, Yong Seok Lee, David S Lu, Bita V Naini, Michael P Harlander-Locke, Ronald W Busuttil, Vatche G Agopian
Mixed hepatocellular-cholangiocarcinomas (HCC-CCA) are rare tumors with both hepatocellular and biliary differentiation. While liver transplantation (LT) is the gold standard treatment for patients with unresectable hepatocellular carcinoma (HCC), it is contraindicated in known HCC-CCA due to concerns of poor prognosis. We sought to compare post-transplant oncologic outcomes for HCC-CCA and a matched cohort of HCC LT recipients. METHODS: A retrospective, single-center analysis (1984-2015) identified 12 patients with mixed HCC-CCA who were matched 1:3 to patients with HCC on both pretransplant (radiologic diameter and AFP) and explant (pathologic diameter, grade/differentiation, and vascular invasion) tumor characteristics...
March 23, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29551704/spatial-and-temporal-clonal-evolution-of-intrahepatic-cholangiocarcinoma
#8
Liang-Qing Dong, Yang Shi, Li-Jie Ma, Liu-Xiao Yang, Xiao-Ying Wang, Shu Zhang, Zhi-Chao Wang, Meng Duan, Zhao Zhang, Long-Zi Liu, Bo-Hao Zheng, Zhen-Bin Ding, Ai-Wu Ke, Da-Ming Gao, Ke Yuan, Jian Zhou, Jia Fan, Ruibin Xi, Qiang Gao
BACKGROUND & AIMS: Intrahepatic cholangiocarcinoma (ICC) is the second-most lethal primary liver cancer. Little is known about intratumoral heterogeneity (ITH) and its impact on ICC progression. We aim to investigate its ITH in hope of helping develop new therapeutic strategies. METHODS: We obtained 69 spatially distinct regions from 6 operable ICCs. Patient-derived primary cancer cells (PDPCs) were established for each region, followed by whole-exome sequencing(WES) and multi-level validation...
March 15, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29549357/igg4-associated-cholangitis-in-patients-resected-for-presumed-perihilar-cholangiocarcinoma-a-30-year-tertiary-care-experience
#9
Eva Roos, Lowiek M Hubers, Robert J S Coelen, Marieke E Doorenspleet, Niek de Vries, Joanne Verheij, Ulrich Beuers, Thomas M van Gulik
BACKGROUND: Distinguishing perihilar cholangiocarcinoma (PHC) from benign forms of sclerosing cholangitis affecting the hilar bile ducts is challenging, since histological confirmation of PHC is difficult to obtain and accurate non-invasive diagnostic tests are not available. IgG4-associated cholangitis (IAC), an imitator of PHC, may present with clinical and radiographical signs of PHC. IAC can be accurately diagnosed with a novel qPCR test. The aim of this study was to investigate the incidence and long-term activity of IAC in patients resected for PHC in a single tertiary center over a period of 30 years...
March 16, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29548617/liver-transplantation-for-locally-advanced-intrahepatic-cholangiocarcinoma-treated-with-neoadjuvant-therapy-a-prospective-case-series
#10
Keri E Lunsford, Milind Javle, Kirk Heyne, Rachna T Shroff, Reham Abdel-Wahab, Nakul Gupta, Constance M Mobley, Ashish Saharia, David W Victor, Duc T Nguyen, Edward A Graviss, Ahmed O Kaseb, Robert S McFadden, Thomas A Aloia, Claudius Conrad, Xian C Li, Howard P Monsour, A Osama Gaber, Jean-Nicolas Vauthey, R Mark Ghobrial
BACKGROUND: At present, intrahepatic cholangiocarcinoma is a contraindication for liver transplantation. However, previous studies in this field did not preselect patients on the basis of chemosensitivity or disease trajectory after neoadjuvant therapy. Experience with hilar cholangiocarcinoma has indicated that neoadjuvant therapy followed by liver transplantation in patients without disease progression results in a long-term survival benefit. We aimed to establish the potential efficacy of liver transplantation in patients with biologically responsive intrahepatic cholangiocarcinoma who have had sustained tumour stability or regression with neoadjuvant therapy...
March 13, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29523614/selective-internal-radiation-therapy-sirt-with-yttrium-90-microspheres-for-unresectable-intrahepatic-cholangiocarcinoma
#11
Vindya Abeysinghe, Siva Sundararajan, Luc Delriviere, Jonathan Tibballs
Unresectableintrahepaticcholangiocarcinoma has a very poor prognosis despite various treatment options. The case presented describes the diagnostic challenges of a young pregnant woman with unresectable cholangiocarcinoma. The current treatment options for cholangiocarcinoma have limited evidence and high recurrence rate. Given the young age of this patient, selective internal radiotherapy was trialled with traditional chemotherapy with a clinically significant result. This case highlights the delays when diagnosing cholangiocarcinoma in younger patients and the possibility of selective internal radiation therapy in combination with chemotherapy as a potential first-line treatment for a complete response in unresectable disease...
March 9, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29514406/caveat-emptor-liver-transplantation-for-intrahepatic-cholangiocarcinoma-a-diagnostic-conundrum-for-44-patients-at-a-single-center
#12
David D Lee, Kristopher P Croome, Kaitlyn R Musto, Jose Melendez, Ghassan Tranesh, Raouf Nakhleh, C Burcin Taner, Justin H Nguyen, Tushar Patel, Denise M Harnois
Background While hepatocellular carcinoma (HCC) has become a common indication for liver transplantation (LT), intrahepatic cholangiocarcinoma (ICC) and combined-Hepatocellular-cholangiocarcioma (cHCC-CC) are historically contraindicated due to their aggressive behavior. Based on recent experiences, some groups have proposed a clinical trial investigating the role of LT for patients with early CC, defined as a single lesion ≤ 2cm. The purpose of this study is to assess the clinicopathologic features and outcomes following LT for patients who were initially diagnosed with HCC and subsequently found to have either ICC or cHCC-CC on explant...
March 7, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29511872/chemoradiotherapy-for-initially-unresectable-locally-advanced-cholangiocarcinoma
#13
Tatsuaki Sumiyoshi, Yasuo Shima, Takehiro Okabayashi, Yuji Negoro, Yasuhiro Shimada, Jun Iwata, Manabu Matsumoto, Yasuhiro Hata, Yoshihiro Noda, Kenta Sui, Taijiro Sueda
OBJECTIVE: Surgical resection is the only available treatment for achieving long-term survival in cholangiocarcinoma. The purpose of this study is to elucidate the utility of chemoradiotherapy for initially unresectable locally advanced cholangiocarcinoma. METHODS: Unresectable locally advanced cholangiocarcinoma was defined as those in which radical surgery could not be achieved even with aggressive surgical procedure. Fifteen candidates (7 intrahepatic cholangiocarcinomas and 8 hilar cholangiocarcinomas) underwent chemoradiotherapy...
March 6, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29511555/impact-of-age-at-diagnosis-on-disease-progression-in-patients-with-primary-sclerosing-cholangitis
#14
Christian Rupp, Alexander Rössler, Taotao Zhou, Conrad Rauber, Kilian Friedrich, Andreas Wannhoff, Karl-Heinz Weiss, Peter Sauer, Peter Schirmacher, Caner Süsal, Wolfgang Stremmel, Daniel N Gotthardt
Background: The median age of diagnosis of primary sclerosing cholangitis (PSC) is ∼30-40 years. Objective: We aimed to analyse disease progression and liver-dependent survival in patients diagnosed with PSC after 50 years of age. Methods: Patients with PSC were analysed with regard to their age at diagnosis. Patients with a first diagnosis of PSC after the age of 50 years were considered as the late-onset group. Results: A total of 32/215 (14...
March 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29510695/cd133-expression-in-cancer-cells-predicts-poor-prognosis-of-non-mucin-producing-intrahepatic-cholangiocarcinoma
#15
Xiaobo Cai, Jun Li, Xiaodong Yuan, Jingbo Xiao, Steven Dooley, Xinjian Wan, Honglei Weng, Lungen Lu
BACKGROUND: CD133 is a marker of stem cells as well cancer stem cells. This study investigated the association between CD133 expression in cancer cells and the clinical outcome of non-mucin producing intrahepatic cholangiocarcinoma (ICC). METHODS: Fifty-seven non-mucin producing ICC patients were enrolled in this study. Immunohistochemistry (IHC) and immunofluorescence staining for CD133 as well as other cancer-associated proteins, including cytokeratin 19, TGF-β1, p-Smad2 and epithelial-mesenchymal transition (EMT) markers S100A4, E-Cadherin and Vimentin were analyzed...
March 6, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29510098/management-of-right-gastroepiploic-arterial-coronary-grafts-in-subsequent-abdominal-surgeries
#16
Kenji Sakai, Tomohiro Mizuno, Taiju Watanabe, Eiki Nagaoka, Keiji Oi, Masafumi Yashima, Tsuyoshi Hachimaru, Hidehito Kuroki, Tatsuki Fujiwara, Masashi Takeshita, Minoru Tanabe, Hirokuni Arai
BACKGROUND: The right gastroepiploic artery (GEA) is utilized as an excellent in-situ arterial graft conduit to right coronary artery territory for coronary artery bypass grafting (CABG). However, there remains great concerns regarding the management of patients with a patent in-situ GEA during abdominal surgery following CABG. METHODS: From 1995 to 2016, GEA was used for CABG in 278 patients at our institution. Of the patients, 14 abdominal surgeries were performed for subsequent abdominal diseases in 11 patients with a patent in-situ GEA for CABG...
March 3, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29504997/clinicopathological-features-of-combined-hepatocellular-cholangiocarcinoma-with-sarcomatous-change-case-report-and-literature-review
#17
Qianru Gu, Xia Yu, Hanbin Chen, Guorong Chen
RATIONALE: Combined hepatocellular-cholangiocarcinoma (cHCC-CC) is a rare subtype of primary liver malignancy comprising <1.5% of all primary liver tumors. Sarcomatoid changes in cHCC-CC are even rarer. Due to the rarity of this subtype, its clinicopathological feature is poorly understood. Therefore, here we report 2 tumors. PATIENT CONCERNS: The first patient was a 44-year-old man with 5-year history of hepatitis B-induced cirrhosis. The resection of right liver revealed a 2...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29492607/intrahepatic-cholangiocarcinoma-can-imaging-phenotypes-predict-survival-and-tumor-genetics
#18
Emily A Aherne, Linda M Pak, Debra A Goldman, Mithat Gonen, William R Jarnagin, Amber L Simpson, Richard K Do
PURPOSE: On computed tomography (CT), intrahepatic cholangiocarcinomas (ICC) are a visibly heterogeneous group of tumors. The purpose of this study was to investigate the associations between CT imaging phenotypes, patient survival, and known genetic markers. METHODS: A retrospective study was performed with 66 patients with surgically resected ICC. Pre-surgical CT images of ICC were assessed by radiologists blinded to tumor genetics and patient clinical data. Associations between qualitative imaging features and overall survival (OS) and disease-free survival (DFS) were performed with Cox proportional hazards regression and visualized with Kaplan-Meier plots...
February 28, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29486735/positive-expression-of-midkine-predicts-early-recurrence-and-poor-prognosis-of-initially-resectable-combined-hepatocellular-cholangiocarcinoma
#19
Ming-Chun Ma, Yi-Ju Chen, Tai-Jan Chiu, Jui Lan, Chien-Ting Liu, Yi-Ching Chen, Hsin-Ho Tien, Yen-Yang Chen
BACKGROUND: Post-surgical prognosis is usually poor for combined hepatocellular cholangiocarcinoma (CHCC-CC), a rare primary liver cancer. Although midkine (MK) is a prognostic biomarker for several known cancers, it is not known whether it can be used as such in resectable CHCC-CC. This study examined whether MK expression can predict recurrence and survival in patients with resectable CHCC-CC. METHODS: We retrospectively enrolled 52 patients with resectable CHCC-CC who had received curative hepatic resections...
February 27, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29452711/primary-sclerosing-cholangitis
#20
REVIEW
Jessica K Dyson, Ulrich Beuers, David E J Jones, Ansgar W Lohse, Mark Hudson
Primary sclerosing cholangitis is a rare, chronic cholestatic liver disease characterised by intrahepatic or extrahepatic stricturing, or both, with bile duct fibrosis. Inflammation and fibrosis of bile ducts and the liver are followed by impaired bile formation or flow and progressive liver dysfunction. Patients might be asymptomatic at presentation or might have pruritus, fatigue, right upper quadrant pain, recurrent cholangitis, or sequelae of portal hypertension. The key diagnostic elements are cholestatic liver biochemistry and bile duct stricturing on cholangiography...
February 13, 2018: Lancet
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