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Recurrent hilar cholangiocarcinoma

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https://www.readbyqxmd.com/read/29404753/defining-early-recurrence-of-hilar-cholangiocarcinoma-after-curative-intent-surgery-a-multi-institutional-study-from-the-us-extrahepatic-biliary-malignancy-consortium
#1
Xu-Feng Zhang, Eliza W Beal, Jeffery Chakedis, Qinyu Chen, Yi Lv, Cecilia G Ethun, Ahmed Salem, Sharon M Weber, Thuy Tran, George Poultsides, Andre Y Son, Ioannis Hatzaras, Linda Jin, Ryan C Fields, Stefan Buettner, Charles Scoggins, Robert C G Martin, Chelsea A Isom, Kamron Idrees, Harveshp D Mogal, Perry Shen, Shishir K Maithel, Carl R Schmidt, Timothy M Pawlik
BACKGROUND: Time to tumor recurrence may be associated with outcomes following resection of hepatobiliary cancers. The objective of the current study was to investigate risk factors and prognosis among patients with early versus late recurrence of hilar cholangiocarcinoma (HCCA) after curative-intent resection. METHODS: A total of 225 patients who underwent curative-intent resection for HCCA were identified from 10 academic centers in the USA. Data on clinicopathologic characteristics, pre-, intra-, and postoperative details and overall survival (OS) were analyzed...
February 5, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29398035/perioperative-and-long-term-outcome-of-intrahepatic-cholangiocarcinoma-involving-the-hepatic-hilus-after-curative-intent-resection-comparison-with-peripheral-intrahepatic-cholangiocarcinoma-and-hilar-cholangiocarcinoma
#2
Xu-Feng Zhang, Fabio Bagante, Qinyu Chen, Eliza W Beal, Yi Lv, Matthew Weiss, Irinel Popescu, Hugo P Marques, Luca Aldrighetti, Shishir K Maithel, Carlo Pulitano, Todd W Bauer, Feng Shen, George A Poultsides, Olivier Soubrane, Guillaume Martel, B Groot Koerkamp, Alfredo Guglielmi, Endo Itaru, Timothy M Pawlik
BACKGROUND: Intrahepatic cholangiocarcinoma with hepatic hilus involvement has been either classified as intrahepatic cholangiocarcinoma or hilar cholangiocarcinoma. The present study aimed to investigate the clinicopathologic characteristics and short- and long-term outcomes after curative resection for hilar type intrahepatic cholangiocarcinoma in comparison with peripheral intrahepatic cholangiocarcinoma and hilar cholangiocarcinoma. METHODS: A total of 912 patients with mass-forming peripheral intrahepatic cholangiocarcinoma, 101 patients with hilar type intrahepatic cholangiocarcinoma, and 159 patients with hilar cholangiocarcinoma undergoing curative resection from 2000 to 2015 were included from two multi-institutional databases...
February 1, 2018: Surgery
https://www.readbyqxmd.com/read/29394618/-a-case-of-resected-metachronous-cholangiocarcinoma-after-pancreaticoduodenectomy
#3
Kazuhiko Hashimoto, Kei Adachi, Ryouji Nonaka, Jeong-Ho Moon, Yujiro Fujie, Shoichiro Fujita, Keiko Kojima, Jun Hanai, Shingi Imaoka, Tadashi Ohnishi
The patient was a 79-year-old woman, who had undergone pancreaticoduodenectomy(PD)for lower bile duct carcinoma in our hospital(pT3N0H0P0M0, fStage III ). Four years 6 months after the initial operation, abdominal CT revealed left bile duct expansion and hilar bile duct thickening. Therefore, based on the diagnosis of perihilar cholangiocarcinoma originating from the left hilar duct, we performed left lobectomy with caudate lobectomy and biliary tract reconstruction. The surgical specimen showed a tumor in the left hilar bile duct...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29369964/laparoscopic-hilar-lymph-node-sampling-in-patients-with-biliary-tract-cancers-that-are-rarely-associated-with-nodal-metastasis
#4
Shogo Kobayashi, Akira Tomokuni, Hidenori Takahashi, Hirofumi Akita, Shigeru Marubashi, Kunihito Gotoh, Yoshitomo Yanagimoto, Yusuke Takahashi, Keijiro Sugimura, Norikatsu Miyoshi, Jeong Ho Moon, Masayoshi Yasui, Takeshi Omori, Hiroshi Miyata, Masayuki Ohue, Yoshiyuki Fujiwara, Masahiko Yano, Masato Sakon
PURPOSE: Among the various types of biliary tract cancer, patients with single, small (<5 cm), peripheral intrahepatic cholangiocarcinoma (ICC), or small (<2 cm) gallbladder tumors (GBTs) rarely develop lymph node (LN) metastasis. We investigated a laparoscopic approach for hilar LN sampling in such cases. METHODS: Among the 176 patients with biliary tract cancer who were treated from January 2012 to March 2017, 21 (ICC, n=4; GBT, n=17) met the above indications...
January 24, 2018: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/29306541/the-impact-of-caudate-lobe-resection-on-margin-status-and-outcomes-in-patients-with-hilar-cholangiocarcinoma-a-multi-institutional-analysis-from-the-us-extrahepatic-biliary-malignancy-consortium
#5
Neal Bhutiani, Charles R Scoggins, Kelly M McMasters, Cecilia G Ethun, George A Poultsides, Timothy M Pawlik, Sharon M Weber, Carl R Schmidt, Ryan C Fields, Kamran Idrees, Ioannis Hatzaras, Perry Shen, Shishir K Maithel, Robert C G Martin
BACKGROUND: The objective of this study was to determine the impact of caudate resection on margin status and outcomes during resection of extrahepatic hilar cholangiocarcinoma. METHODS: A database of 1,092 patients treated for biliary malignancies at institutions of the Extrahepatic Biliary Malignancy Consortium was queried for individuals undergoing curative-intent resection for extrahepatic hilar cholangiocarcinoma. Patients who did versus did not undergo concomitant caudate resection were compared with regard to demographic, baseline, and tumor characteristics as well as perioperative outcomes...
January 3, 2018: Surgery
https://www.readbyqxmd.com/read/29284072/adjuvant-therapy-is-associated-with-improved-survival-after-curative-resection-for-hilar-cholangiocarcinoma-a-multi-institution-analysis-from-the-u-s-extrahepatic-biliary-malignancy-consortium
#6
Bradley A Krasnick, Linda X Jin, Jesse T Davidson, Dominic E Sanford, Cecilia G Ethun, Timothy M Pawlik, George A Poultsides, Thuy Tran, Kamran Idrees, William G Hawkins, William C Chapman, Maria B M Doyle, Sharon M Weber, Steven M Strasberg, Ahmed Salem, Robert C G Martin, Chelsea A Isom, Charles Scoggins, Carl R Schmidt, Perry Shen, Eliza Beal, Ioannis Hatzaras, Rivfka Shenoy, Shishir K Maithel, Ryan C Fields
BACKGROUND: Curative-intent treatment for localized hilar cholangiocarcinoma (HC) requires surgical resection. However, the effect of adjuvant therapy (AT) on survival is unclear. We analyzed the impact of AT on overall (OS) and recurrence free survival (RFS) in patients undergoing curative resection. METHODS: We reviewed patients with resected HC between 2000 and 2015 from the ten institutions participating in the U.S. Extrahepatic Biliary Malignancy Consortium...
December 28, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29205351/oncologic-effects-of-preoperative-biliary-drainage-in-resectable-hilar-cholangiocarcinoma-percutaneous-biliary-drainage-has-no-adverse-effects-on-survival
#7
Xu-Feng Zhang, Eliza W Beal, Katiuscha Merath, Cecilia G Ethun, Ahmed Salem, Sharon M Weber, Thuy Tran, George Poultsides, Andre Y Son, Ioannis Hatzaras, Linda Jin, Ryan C Fields, Matthew Weiss, Charles Scoggins, Robert C G Martin, Chelsea A Isom, Kamron Idrees, Harveshp D Mogal, Perry Shen, Shishir K Maithel, Carl R Schmidt, Timothy M Pawlik
BACKGROUND AND OBJECTIVES: The objective of the current study was to define long-term survival of patients with resectable hilar cholangiocarcinoma (HCCA) after preoperative percutaneous transhepatic biliary drainage (PTBD) versus endoscopic biliary drainage (EBD). METHODS: Between 2000 and 2014, 240 patients who underwent curative-intent resection for HCCA were identified at 10 major hepatobiliary centers. Postoperative morbidity and mortality, as well as disease-specific survival (DSS) and recurrence-free survival (RFS) were analyzed among patients...
December 4, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29202005/side-by-side-partially-covered-self-expandable-metal-stent-placement-for-malignant-hilar-biliary-obstruction
#8
Katsuya Kitamura, Akira Yamamiya, Yu Ishii, Yuta Mitsui, Tomohiro Nomoto, Hitoshi Yoshida
Background and study aims:  This study investigated the feasibility of side-by-side (SBS) partially covered self-expandable metal stent (PCSEMS) placement for unresectable malignant hilar biliary obstruction (MHBO). Patients and methods:  We retrospectively analyzed 33 patients from a single center who underwent endoscopic biliary drainage for unresectable MHBO from July 2013 to June 2015. In all patients with bilateral obstruction during complete bilateral intrahepatic cholangiograms, we performed endoscopic SBS placement of a 6-mm diameter PCSEMS using an 8-French delivery system...
December 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29118686/hepatectomy-for-hilar-cholangiocarcinoma-with-right-sided-ligamentum-teres-using-a-hepatectomy-simulation-system
#9
Seikan Hai, Etsuro Hatano, Tadamichi Hirano, Yasukane Asano, Kazuhiro Suzumura, Hideaki Sueoka, Jiro Fujimoto
Right-sided ligamentum teres (RSLT) is a rare congenital anomaly often accompanied by variation of the hepatic vasculature. We herein report a surgical case of a hilar cholangiocarcinoma with RSLT in whom preoperative hepatectomy simulation proved useful for understanding the anatomical structure of the liver. A 78-year-old male with obstructive jaundice was referred to our department for further examination. The patient was suspected of having a hilar cholangiocarcinoma originating from the left hepatic bile duct by contrast-enhanced computed tomography (CT), and CT also showed right umbilical portion (RUP)...
September 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29063849/prognostic-factors-and-patterns-of-locoregional-failure-after-surgical-resection-in-patients-with-cholangiocarcinoma-without-adjuvant-radiation-therapy-optimal-field-design-for-adjuvant-radiation-therapy
#10
Zahra Ghiassi-Nejad, Paola Tarchi, Erin Moshier, Meng Ru, Parissa Tabrizian, Myron Schwartz, Michael Buckstein
PURPOSE: To identify prognostic factors and patterns of local failure in patients with cholangiocarcinoma (CCA), after surgical resection in the absence of adjuvant radiation, for optimal definition of target volumes encompassing the majority of local recurrences. METHODS AND MATERIALS: A chart review was performed in patients who underwent resection for primary CCA (intrahepatic, hilar, and distal) between 1999 and 2014. Local failure was defined as recurrence in a theoretical reasonable postoperative radiation volume...
November 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29039079/a-long-term-survivor-of-hilar-cholangiocarcinoma-with-resection-of-recurrent-peritoneal-dissemination-after-r0-surgery-a-case-report
#11
Tatsunori Miyata, Hirohisa Okabe, Akira Chikamoto, Takanobu Yamao, Naoki Umezaki, Masayo Tsukamoto, Yuki Kitano, Kota Arima, Shigeki Nakagawa, Katsunori Imai, Daisuke Hashimoto, Yo-Ichi Yamashita, Hideo Baba
BACKGROUND: Although hilar cholangiocarcinoma (HCCA) has a very poor prognosis, there are cases in which long-term survival is rarely obtained by multidisciplinary treatment. CASE PRESENTATION: A 61-year-old man diagnosed with HCCA was referred to our hospital. We performed an extended left hemi-hepatectomy and caudate lobectomy with extrahepatic bile duct resection. The tumor stage was T2aN0M0, stage II, based on the TNM classification, seventh edition. R0 resection was successfully performed...
October 16, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/29033254/nodal-areas-of-potential-geographic-error-in-adjuvant-radiotherapy-for-biliary-tract-cancer
#12
Joanna Socha, Maciej Michalak, Grzegorz Wołąkiewicz, Lucyna Kepka
PURPOSE: To determine the areas of potential geographic error in adjuvant radiotherapy (RT) for biliary-tract cancer (BTC) by comparing pathological-surgical data on the pattern of nodal spread with the extent of elective nodal CTV used in published RT studies in this setting. MATERIAL/METHODS: A literature search was performed to select articles on: 1/adjuvant RT for BTC, that provided information on the lymph node stations (LNS) included in the CTV; 2/the pathological-surgical data on the patterns of nodal involvement/recurrence in BTC...
October 12, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28982905/immunohistochemical-comparison-of-malignancy-between-radial-invasion-and-mucosal-extension-in-hilar-cholangiocarcinoma
#13
COMPARATIVE STUDY
Kenichi Yoshida, Ryusei Matsuyama, Ryutaro Mori, Takafumi Kumamoto, Kenichi Matsuo, Kazuhisa Takeda, Mitsutaka Sugita, Yoshiro Fujii, Kuniya Tanaka, Hiroshi Shimada, Itaru Endo
AIM: To compare the cells of mucosal extension (ME) and radial invasion (RI) in hilar cholangiocarcinoma (HCCA) for optimal resection. MATERIALS AND METHODS: Forty-six patients underwent surgery for HCCA between 1992 and 2004. Immunohistochemical expressions of p53, Ki-67, matrix metalloproteinase-7 (MMP7), mucin 1 (MUC1), and E-cadherin were assessed at five different sites of the tumour and compared between the recurrence and non-recurrence groups. RESULTS: Expression of E-cadherin was significantly lower in RI cells than in ME cells, and that of MMP7 and MUC1 was significantly higher in RI cells than in ME cells...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28919993/tumor-necrosis-and-infiltrating-macrophages-predict-survival-after-curative-resection-for-cholangiocarcinoma
#14
Georgi Atanasov, Corinna Dietel, Linda Feldbrügge, Christian Benzing, Felix Krenzien, Andreas Brandl, Elli Mann, Julianna Paulina Englisch, Katrin Schierle, Simon C Robson, Katrin Splith, Mehmet Haluk Morgul, Anja Reutzel-Selke, Sven Jonas, Andreas Pascher, Marcus Bahra, Johann Pratschke, Moritz Schmelzle
Background. Tumor necrosis as well as tumor-associated macrophages (TAMs) in the tumor invasive front (TIF) have been suggested to have a prognostic value in selected solid tumors, inclusive hilar cholangiocarcinoma. However, little is known regarding their influence on tumor progression and prognosis in intrahepatic cholangiocarcinoma (iCC). Methods. We analyzed surgically resected tumor specimens of human iCC (n = 88) for distribution and localization of TAMs, as defined by expression of CD68, formation of necrosis and extent of peritumoral fibrosis...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28875398/total-hilar-en-bloc-resection-with-left-hemihepatectomy-and-caudate-lobectomy-a-novel-approach-for-treatment-of-left-sided-perihilar-cholangiocarcinoma-with-video
#15
Cai De Lu, Jing Huang, Sheng Dong Wu, Yong Fei Hua, Ammar A Javed, Jiong Zhe Fang, Chun Nian Wang, Sheng Ye
BACKGROUND: "Hilar en bloc resection" using a no-touch technique has been advocated as a standard procedure in right-sided hepatectomies for treatment of perihilar cholangiocarcinoma (PHC). In principle, it has never been reported for left-sided tumors. The aim is to describe the procedures of total hilar en bloc resection with left hemihepatectomy and caudate lobectomy (THER-LH) for advanced PHC and discuss feasibility and clinical significance of this novel technique. METHODS: A retrospective study using a prospectively maintained database was performed to identify eight patients who had received THER-LH for advanced PHC from January 2013 to December 2015...
November 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28675365/extension-of-hepatic-resection-ameliorates-survival-in-patients-with-type-iiia-or-iiib-klatskin-tumors-despite-surgical-complications
#16
Radu Razvan Scurtu, George Dindelegan, Vasile Bintintan, Radu Drasovean, Raluca Apostu, Constantin Ciuce
Background: Major hepatectomies for hilar cholangiocarcinoma (HC) are associated with high rates of morbidity and mortality. We aimed to evaluate how and if surgical complications related to extended hepatectomies for HC type III and IV according to Bismuth-Corlette classification influence patients long-term survival. Methods: The files of all patients with major hepatectomy for HC and postoperative complications were retrospectively reviewed. Only patients with a complete postoperative follow up have be taken into account for the study...
May 2017: Chirurgia
https://www.readbyqxmd.com/read/28603094/liver-transplantation-in-patients-with-incidental-hepatocellular-carcinoma-cholangiocarcinoma-and-intrahepatic-cholangiocarcinoma-a-single-center-experience
#17
Mohammed Elshamy, Naftali Presser, Abdulrahman Y Hammad, Daniel J Firl, Christopher Coppa, John Fung, Federico N Aucejo
BACKGROUND: Reports of liver transplantation (LT) in patients with mixed hepatocellular carcinoma/cholangiocarcinoma (HCC/CC) and intrahepatic cholangiocarcinoma (ICC) are modest and have been mostly retrospective after pathological categorization in the setting of presumed HCC. Some studies suggest that patients undergoing LT with small and unifocal ICC or mixed HCC/CC can achieve about 40%-60% 5-year post-transplant survival. The study aimed to report our experience in patients undergoing LT with explant pathology revealing HCC/CC and ICC...
June 2017: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/28588786/isolated-brain-metastases-prior-to-locoregional-recurrence-in-hilar-cholangiocarcinoma
#18
Zhimin Yu, Junyao Xu, Jie Wang
Isolated brain metastases prior to locoregional recurrence from hilar cholangiocarcinoma (HCCA) following curative resection are an extremely rare event. Very few reports regarding brain metastasis prior to locoregional recurrence following curative resection have been published due to the fact that to differentiate brain metastases from HCCA recurrence is challenging, particular in the early stages, since the neurological findings of brain metastasis are occult and subtle. Any patient with HCCA who has undergone radical resection and subsequently presented with a further onset of neurological symptoms should be evaluated for brain involvement...
June 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28484084/can-preoperative-and-postoperative-ca19-9-levels-predict-survival-and-early-recurrence-in-patients-with-resectable-hilar-cholangiocarcinoma
#19
Jun-Ke Wang, Hai-Jie Hu, Anuj Shrestha, Wen-Jie Ma, Qin Yang, Fei Liu, Nan-Sheng Cheng, Fu-Yu Li
BACKGROUND: To investigate the predictive values of preoperative and postoperative serum CA19-9 levels on survival and other prognostic factors including early recurrence in patients with resectable hilar cholangiocarcinoma. RESULTS: In univariate analysis, increased preoperative and postoperative CA19-9 levels in the light of different cut-off points (37, 100, 150, 200, 400, 1000 U/ml) were significantly associated with poor survival outcomes, of which the cut-off point of 150 U/ml showed the strongest predictive value (both P < 0...
July 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28420643/isolated-implant-metastasis-in-chest-wall-due-to-seeding-of-transpleurally-placed-ptbd-catheter-tract-in-a-case-of-hilar-cholangiocarcinoma
#20
Shibojit Talukder, Arunanshu Behera, Cherring Tandup, Suvradeep Mitra
Percutaneous transhepatic biliary drainage (PTBD) catheter site metastasis in cases of cholangiocarcinoma is reported sporadically. But it is unusual to see left-sided tumour metastasising to the right PTBD catheter site. Metastasis, in general, has a poor prognosis, but recurrence along the catheter tract in the absence of other systemic diseases can be a different scenario altogether. To date, there is no consensus on the management of this form of metastasis. But carefully selected patients can benefit from aggressive surgical resection...
April 18, 2017: BMJ Case Reports
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