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Recurrant cholangiocarcinoma

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https://www.readbyqxmd.com/read/28712702/clinical-usefulness-of-f-18-fdg-pet-in-lymphoepithelioma-like-gastric-carcinoma
#1
Soyeon Park, Dakeun Lee, Kee Myung Lee, Sang-Uk Han, Jei Hee Lee, Su Jin Lee, Young-Sil An, Joon-Kee Yoon
PURPOSE: Lymphoepithelioma-like carcinoma (LELC) is a rare type of gastric cancer. We evaluated the clinical usefulness of F-18 FDG positron emission tomography/computed tomography (PET/CT) in LELC of stomach. MATERIALS AND METHODS: A total of 28 patients (mean age=59years) who underwent preoperative F-18 FDG PET/CT were enrolled retrospectively. Nine patients underwent follow-up F-18 FDG PET/CT. Pathologic information was obtained through gastrectomy and the association with Epstein-Barr virus (EBV) was investigated in 26 patients...
June 27, 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28707055/histological-heterogeneity-in-primary-and-metastatic-classic-combined-hepatocellular-cholangiocarcinoma-a-case-series
#2
Claudio De Vito, Debashis Sarker, Paul Ross, Nigel Heaton, Alberto Quaglia
Combined hepatocellular-cholangiocarcinoma (cHCC-CC) is a rare and aggressive primary liver cancer with both hepatocellular and cholangiocellular differentiation. Due to its bi-phenotypic component, cHCC-CC is a heterogeneous tumour and histopathological analysis of metastatic deposits is poorly characterized. In this retrospective study, we describe four patients in whom the histology from resected specimens of both primary and recurrent and/or metastatic tumour was available for comparison and immunohistochemical characterization...
July 13, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28703880/performance-of-prognostic-scores-and-staging-systems-in-predicting-long-term-survival-outcomes-after-surgery-for-intrahepatic-cholangiocarcinoma
#3
Stefan Buettner, Boris Galjart, Jeroen L A van Vugt, Fabio Bagante, Sorin Alexandrescu, Hugo P Marques, Jorge Lamelas, Luca Aldrighetti, T Clark Gamblin, Shishir K Maithel, Carlo Pulitano, Georgios A Margonis, Matthew Weiss, Todd W Bauer, Feng Shen, George A Poultsides, J Wallis Marsh, Jan N M IJzermans, Bas Groot Koerkamp, Timothy M Pawlik
INTRODUCTION: We sought to validate the commonly used prognostic models and staging systems for intrahepatic cholangiocarcinoma (ICC) in a large multi-center patient cohort. METHODS: The overall (OS) and disease free survival (DFS) prognostic discriminatory ability of various commonly used models were assessed in a large retrospective cohort. Harrell's concordance index (c-index) was used to determine accuracy of model prediction. RESULTS: Among 1054 ICC patients, median OS was 37...
July 13, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28693238/intranuclear-accumulation-of-galectin-3-is-an-independent-prognostic-factor-for-patients-with-distal-cholangiocarcinoma
#4
Tatsuo Shimura, Yasuhide Kofunato, Ryo Okada, Rei Yashima, Yoshihisa Koyama, Kenichiro Araki, Hiroyuki Kuwano, Seiichi Takenoshita
Galectin-3 has been reported to be associated with the prognosis of patients with various malignancies; however, it has not yet been investigated in patients with extrahepatic cholangiocarcinoma (EHCC). Expression of galectin-3 was retrospectively examined in 58 patients with EHCC: 21 with perihilar cholangiocarcinoma and 37 with distal cholangiocarcinoma (DCC). The Cox proportional hazard model was used to identify independent prognostic factors. Intranuclear accumulation of galectin-3 (gal-3-INA) was associated with poorer overall survival (OS) in all patients (P=0...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28688518/neutrophil-to-lymphocyte-ratio-predicts-prognosis-after-neoadjuvant-chemotherapy-and-resection-of-intrahepatic-cholangiocarcinoma
#5
Kiyohiko Omichi, Jordan M Cloyd, Suguru Yamashita, Ching-Wei D Tzeng, Claudius Conrad, Yun Shin Chun, Thomas A Aloia, Jean-Nicolas Vauthey
BACKGROUND: Previous studies have demonstrated a strong association between the preoperative neutrophil-to-lymphocyte ratio and the outcomes of patients with resected hepatocellular carcinoma and colorectal liver metastases. However, the predictive ability of neutrophil-to-lymphocyte ratio in patients with intrahepatic cholangiocarcinoma, especially those treated with preoperative chemotherapy, has been less well described. METHODS: The clinicopathological characteristics, overall survival, and recurrence free survival of all patients with intrahepatic cholangiocarcinoma resected between 2000-2015, were compared between those with elevated (≥3...
July 5, 2017: Surgery
https://www.readbyqxmd.com/read/28684265/prognostic-significance-of-preoperative-albumin-to-globulin-ratio-in-patients-with-cholangiocarcinoma
#6
Q Lin, Z-H Lin, J Chen, J-X Lin, X Li, J-R Jiang, X-K Ma, D-H Wu, Z-H Chen, M Dong, L Wei, T-T Wang, D-Y Ruan, Z-X Lin, J-Y Wen, X-Y Wu, M-S Huang
BACKGROUND: This study aimed to assess the prognostic value of the serum albumin to globulin ratio (AGR) in cholangiocarcinoma patients after surgery. METHODS: We retrospectively enrolled 123 cholangiocarcinoma patients who underwent surgical treatment between June 2003 and September2014 at the Third Affiliated Hospital of Sun Yat-sen University. Univariate and multivariate analyses using the Cox regression model were performed to determine the prognostic value of AGR...
July 3, 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/28675365/extension-of-hepatic-resection-ameliorates-survival-in-patients-with-type-iiia-or-iiib-klatskin-tumors-despite-surgical-complications
#7
Radu Razvan Scurtu, George Dindelegan, Vasile Bintintan, Radu Drasovean, Raluca Apostu, Constantin Ciuce
Background: Major hepatectomies for hilar cholangiocarcinoma (HC) are associated with high rates of morbidity and mortality. We aimed to evaluate how and if surgical complications related to extended hepatectomies for HC type III and IV according to Bismuth-Corlette classification influence patients long-term survival. Methods: The files of all patients with major hepatectomy for HC and postoperative complications were retrospectively reviewed. Only patients with a complete postoperative follow up have be taken into account for the study...
May 2017: Chirurgia
https://www.readbyqxmd.com/read/28675356/current-management-of-perihilar-cholangiocarcinoma-and-future-perspectives
#8
Heather L Lewis, Amir A Rahnemai-Azar, Mary Dillhoff, Carl R Schmidt, Timothy M Pawlik
Perihilar cholangiocarcinoma is the most common type of biliary tract cancer and is associated with a high mortality, usually due to late presentation. High-resolution cross-sectional imaging modalities are necessary for diagnosis and preoperative planning. Although surgical resection with negative margins offers the only hope for cure, only a small subset of patients are amenable for surgery at the time of diagnosis. Portal vein embolization and biliary tract decompression are important in some patients prior to surgical resection...
May 2017: Chirurgia
https://www.readbyqxmd.com/read/28673346/risk-stratification-system-to-predict-recurrence-of-intrahepatic-cholangiocarcinoma-after-hepatic-resection
#9
Seogsong Jeong, Qingbao Cheng, Lifeng Huang, Jian Wang, Meng Sha, Ying Tong, Lei Xia, Longzhi Han, Zhifeng Xi, Jianjun Zhang, Xiaoni Kong, Jinyang Gu, Qiang Xia
BACKGROUND: Previous nomograms for intrahepatic cholangiocarcinoma (ICC) were conducted to predict overall survival, which could be influenced by various factors. Herein, we conducted our nomogram to predict recurrence of the tumor only after hepatic resection. METHODS: The nomogram was established with prognostic factors for the relapse-free survival (RFS) analyzed from our single center cohort and was evaluated by comparing with the American Joint Committee on Cancer (AJCC) staging system for the predictive accuracy...
July 3, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28668872/impact-and-prediction-of-lymph-node-involvement-in-patients-with-intrahepatic-cholangiocarcinoma-after-curative-resection
#10
Noboru Harada, Tomoharu Yoshizumi, Yo-Ichi Yamashita, Yuji Soejima, Toru Ikegami, Norifumi Harimoto, Shinji Itoh, Yoshihiko Maehara
BACKGROUND: The aim of this study was to identify the preoperative predictors of prognosis in patients with intrahepatic cholangiocarcinoma (ICC) undergoing resection. PATIENTS AND METHODS: We enrolled 90 patients with ICC who underwent surgical resection, including 59 in whom surgery was considered curative, and measured the overall survival (OS), recurrence-free survival (RFS), and other outcomes and potential prognostic factors. RESULTS: Multivariate Cox proportional hazards analysis showed that tumor in the resection margins (R>0) independently predicted long-term OS in the whole cohort...
July 2017: Anticancer Research
https://www.readbyqxmd.com/read/28657851/curative-resection-of-single-primary-hepatic-malignancy-liver-imaging-reporting-and-data-system-category-lr-m-portends-a-worse-prognosis
#11
Chansik An, Sumi Park, Yong Eun Chung, Do-Young Kim, Seung-Seob Kim, Myeong-Jin Kim, Jin-Young Choi
OBJECTIVE: The purpose of this study was to examine the associations between preoperative Liver Imaging Reporting and Data System (LI-RADS) categories and prognosis after curative resection of single hepatic malignancies in patients with chronic liver disease. MATERIALS AND METHODS: Between January 2008 and December 2010, 225 patients with chronic liver disease underwent resection of single hepatic malignant tumors (218 hepatocellular carcinomas, three cholangiocarcinomas, four biphenotypic carcinomas) after undergoing gadoxetic acid-enhanced MRI...
June 28, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28652767/prognostic-value-of-high-imp3-expression-in-solid-tumors-a-meta-analysis
#12
Luyao Chen, Yongpeng Xie, Xintao Li, Liangyou Gu, Yu Gao, Lu Tang, Jianwen Chen, Xu Zhang
BACKGROUND: Accumulated studies have investigated the prognostic role of insulin-like growth factor II mRNA-binding protein 3 (IMP3) in various cancers, but inconsistent and controversial results were obtained. Therefore, we performed a systematic review and meta-analysis to investigate the potential value of IMP3 in the prognostic prediction of human solid tumors. MATERIALS AND METHODS: A systematic literature search in the electronic databases PubMed, Embase, Web of Science, and Cochrane library (updated to April 2016) was conducted to identify eligible studies...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28648284/common-molecular-subtypes-among-asian-hepatocellular-carcinoma-and-cholangiocarcinoma
#13
Jittiporn Chaisaingmongkol, Anuradha Budhu, Hien Dang, Siritida Rabibhadana, Benjarath Pupacdi, So Mee Kwon, Marshonna Forgues, Yotsawat Pomyen, Vajarabhongsa Bhudhisawasdi, Nirush Lertprasertsuke, Anon Chotirosniramit, Chawalit Pairojkul, Chirayu U Auewarakul, Thaniya Sricharunrat, Kannika Phornphutkul, Suleeporn Sangrajrang, Maggie Cam, Ping He, Stephen M Hewitt, Kris Ylaya, Xiaolin Wu, Jesper B Andersen, Snorri S Thorgeirsson, Joshua J Waterfall, Yuelin J Zhu, Jennifer Walling, Holly S Stevenson, Daniel Edelman, Paul S Meltzer, Christopher A Loffredo, Natsuko Hama, Tatsuhiro Shibata, Robert H Wiltrout, Curtis C Harris, Chulabhorn Mahidol, Mathuros Ruchirawat, Xin W Wang
Intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) are clinically disparate primary liver cancers with etiological and biological heterogeneity. We identified common molecular subtypes linked to similar prognosis among 199 Thai ICC and HCC patients through systems integration of genomics, transcriptomics, and metabolomics. While ICC and HCC share recurrently mutated genes, including TP53, ARID1A, and ARID2, mitotic checkpoint anomalies distinguish the C1 subtype with key drivers PLK1 and ECT2, whereas the C2 subtype is linked to obesity, T cell infiltration, and bile acid metabolism...
July 10, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28617032/intraductal-papillary-neoplasia-of-the-bile-duct-with-malignancy-a-differentiated-entity-of-cholangiocarcinoma-with-a-better-prognosis-a-review-of-three-new-cases
#14
Baltasar Pérez Saborido, Martín Bailón Cuadrado, Mario Rodríguez López, Enrique Asensio Díaz, Beatriz Madrigal Rubiales, Asterio Barrera Rebollo
INTRODUCTION: Intraductal papillary neoplasms of the bile duct have been recognized as a differentiated entity to other biliary tumors since 2001. They are characterized by intraductal growth, with or without mucus production, and have malignant potential, although they have a better prognosis than other types of cholangiocarcinoma. MATERIAL AND METHODS: From January 2010 to August 2015, we included three patients with a confirmed diagnosis of bile duct intraductal papillary neoplasia with malignancy that were treated at our center...
June 15, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28615696/intraoperative-imaging-of-hepatic-cancers-using-%C3%AE-glutamyltranspeptidase-specific-fluorophore-enabling-real-time-identification-and-estimation-of-recurrence
#15
Yoichi Miyata, Takeaki Ishizawa, Mako Kamiya, Suguru Yamashita, Kiyoshi Hasegawa, Aya Ushiku, Junji Shibahara, Masashi Fukayama, Yasuteru Urano, Norihiro Kokudo
γ-Glutamyltranspeptidase (GGT) is upregulated in a variety of human cancers including primary and secondary hepatic tumors. This motivated us to use γ-glutamyl hydroxymethyl rhodamine green (gGlu-HMRG), a novel fluorophore emitting light at around 520 nm following enzymatic reaction with GGT, as a tool for the intraoperative identification of hepatic tumors. gGlu-HMRG was topically applied to 103 freshly resected hepatic specimens. Fluorescence imaging using gGlu-HMRG identified hepatic tumors with the sensitivity/specificity of 48%/96% for hepatocellular carcinoma, 100%/100% for intrahepatic cholangiocarcinoma, and 87%/100% for colorectal liver metastasis...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28608943/transcriptomic-and-histopathological-analysis-of-cholangiolocellular-differentiation-trait-in-intrahepatic-cholangiocarcinoma
#16
Hyungjin Rhee, Jung Eun Ko, Taek Chung, Byul A Jee, So Mee Kwon, Ji Hae Nahm, Jae Yeon Seok, Jeong Eun Yoo, Jin-Sub Choi, Snorri S Thorgeirsson, Jesper B Andersen, Hye Sun Lee, Hyun Goo Woo, Young Nyun Park
BACKGROUND & AIMS: Intrahepatic cholangiocarcinoma (iCCA) is a heterogeneous entity with diverse etiologies, morphologies, and clinical outcomes. Recently, histopathological distinction of cholangiolocellular differentiation (CD) of iCCA has been suggested. However, its genome-wide molecular features and clinical significance remain unclear. METHODS: Based on CD status, we stratified iCCAs into iCCA with CD (n=20) and iCCA without CD (n=102), and performed an integrative analysis using transcriptomic and clinicopathological profiles...
June 13, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28603094/liver-transplantation-in-patients-with-incidental-hepatocellular-carcinoma-cholangiocarcinoma-and-intrahepatic-cholangiocarcinoma-a-single-center-experience
#17
Mohammed Elshamy, Naftali Presser, Abdulrahman Y Hammad, Daniel J Firl, Christopher Coppa, John Fung, Federico N Aucejo
BACKGROUND: Reports of liver transplantation (LT) in patients with mixed hepatocellular carcinoma/cholangiocarcinoma (HCC/CC) and intrahepatic cholangiocarcinoma (ICC) are modest and have been mostly retrospective after pathological categorization in the setting of presumed HCC. Some studies suggest that patients undergoing LT with small and unifocal ICC or mixed HCC/CC can achieve about 40%-60% 5-year post-transplant survival. The study aimed to report our experience in patients undergoing LT with explant pathology revealing HCC/CC and ICC...
June 2017: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/28602056/declined-preoperative-aspartate-aminotransferase-to-neutrophil-ratio-index-predicts-poor-prognosis-in-patients-with-intrahepatic-cholangiocarcinoma-after-hepatectomy
#18
Lingyun Liu, Wei Wang, Yi Zhang, Jianting Long, Zhaohui Zhang, Qiao Li, Bin Chen, Shaoqiang Li, Yunpeng Hua, Shunli Shen, Baogang Peng
Purpose: Various inflammation-based prognostic biomarkers such as the platelet to lymphocyte ratio and neutrophil to lymphocyte ratio (NLR), are related to poor survival in patients with intrahepatic cholangiocarcinoma (ICC). This study aims to investigate the prognostic value of the aspartate aminotransferase to neutrophil ratio index (ANRI) in ICC after hepatic resection. Materials and Methods: Data of 184 patients with ICC after hepatectomy were retrospectively reviewed...
June 1, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28588786/isolated-brain-metastases-prior-to-locoregional-recurrence-in-hilar-cholangiocarcinoma
#19
Zhimin Yu, Junyao Xu, Jie Wang
Isolated brain metastases prior to locoregional recurrence from hilar cholangiocarcinoma (HCCA) following curative resection are an extremely rare event. Very few reports regarding brain metastasis prior to locoregional recurrence following curative resection have been published due to the fact that to differentiate brain metastases from HCCA recurrence is challenging, particular in the early stages, since the neurological findings of brain metastasis are occult and subtle. Any patient with HCCA who has undergone radical resection and subsequently presented with a further onset of neurological symptoms should be evaluated for brain involvement...
June 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28578306/multiple-recurrent-ischaemic-strokes-in-a-patient-with-cancer-is-there-a-role-for-the-initiation-of-anticoagulation-therapy-for-secondary-stroke-prevention
#20
Giselle Alexandra Suero-Abreu, Jia Zhen Cheng, Ryna Karina Then
A 52-year-old woman with a medical history of cervical and thyroid cancer, hypertension, dyslipidaemia, uncontrolled diabetes and heavy smoking was diagnosed with a new metastatic cholangiocarcinoma. While undergoing palliative chemotherapy, she developed dysarthria and left-sided weakness. Imaging studies showed multiple bilateral ischaemic strokes. On hospital days 2 and 5, she developed worsening neurological symptoms and imaging studies revealed new areas of ischaemia on respective days. Subsequent workup did not revealed a clear aetiology for the multiple ischaemic events and hypercoagulability studies were only significant for a mildly elevated serum D-dimer level...
June 3, 2017: BMJ Case Reports
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