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Recurrant cholangiocarcinoma

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https://www.readbyqxmd.com/read/29039079/a-long-term-survivor-of-hilar-cholangiocarcinoma-with-resection-of-recurrent-peritoneal-dissemination-after-r0-surgery-a-case-report
#1
Tatsunori Miyata, Hirohisa Okabe, Akira Chikamoto, Takanobu Yamao, Naoki Umezaki, Masayo Tsukamoto, Yuki Kitano, Kota Arima, Shigeki Nakagawa, Katsunori Imai, Daisuke Hashimoto, Yo-Ichi Yamashita, Hideo Baba
BACKGROUND: Although hilar cholangiocarcinoma (HCCA) has a very poor prognosis, there are cases in which long-term survival is rarely obtained by multidisciplinary treatment. CASE PRESENTATION: A 61-year-old man diagnosed with HCCA was referred to our hospital. We performed an extended left hemi-hepatectomy and caudate lobectomy with extrahepatic bile duct resection. The tumor stage was T2aN0M0, stage II, based on the TNM classification, seventh edition. R0 resection was successfully performed...
October 16, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/29033254/nodal-areas-of-potential-geographic-error-in-adjuvant-radiotherapy-for-biliary-tract-cancer
#2
Joanna Socha, Maciej Michalak, Grzegorz Wołąkiewicz, Lucyna Kepka
PURPOSE: To determine the areas of potential geographic error in adjuvant radiotherapy (RT) for biliary-tract cancer (BTC) by comparing pathological-surgical data on the pattern of nodal spread with the extent of elective nodal CTV used in published RT studies in this setting. MATERIAL/METHODS: A literature search was performed to select articles on: 1/adjuvant RT for BTC, that provided information on the lymph node stations (LNS) included in the CTV; 2/the pathological-surgical data on the patterns of nodal involvement/recurrence in BTC...
October 12, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29029475/the-prognostic-potential-and-carcinogenesis-of-long-non-coding-rna-tug1-in-human-cholangiocarcinoma
#3
Yi Xu, Kaiming Leng, Zhenglong Li, Fumin Zhang, Xiangyu Zhong, Pengcheng Kang, Xingming Jiang, Yunfu Cui
Cholangiocarcinoma (CCA) is a fatal disease with increasing worldwide incidence and is characterized by poor prognosis due to its poor response to conventional chemotherapy or radiotherapy. Long non-coding RNAs (lncRNAs) play key roles in multiple human cancers, including CCA. Cancer progression related lncRNA taurine-up-regulated gene 1 (TUG1) was reported to be involved in human carcinomas. However, the impact of TUG1 in CCA is unclear. The aim of this study was to explore the expression pattern of TUG1 and evaluate its clinical significance as well as prognostic potential in CCA...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29021470/eus-guided-biliary-drainage-for-malignant-perihilar-biliary-strictures-after-further-transpapillary-intervention-has-been-judged-to-be-impossible-or-ineffective
#4
Yoshihide Kanno, Kei Ito, Shinsuke Koshita, Takahisa Ogawa, Kaori Masu, Hiroaki Kusunose, Toshitaka Sakai, Yoshiharu Masaki, Toji Murabayashi, Sho Hasegawa, Fumisato Kozakai, Jun Horaguchi, Hidenori Matsuo, Yutaka Noda
Objective Patients with perihilar malignancy often develop recurrence of infectious cholangitis, which makes further transpapillary intervention extremely difficult. As EUS-guided biliary drainage (EUS-BD) of an intrahepatic bile duct is a possible option for additional intervention, the aim of this study was to estimate the feasibility of such intervention. Methods and Patients Patients who had undergone EUS-BD after further transpapillary intervention was deemed impossible or ineffective were investigated in this study...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29019563/critical-evaluation-of-long-term-results-of-malignant-hepatic-tumors-treated-by-means-curative-laparoscopic-hepatectomy
#5
Sergio Renato Pais-Costa, Sergio Luiz Melo Araújo, Olímpia Alves Teixeira Lima, Sandro José Martins
BACKGROUND: Laparoscopic hepatectomy has presented great importance for treating malignant hepatic lesions. AIM: To evaluate its impact in relation to overall survival or disease free of the patients operated due different hepatic malignant tumors. METHODS: Thirty-four laparoscopic hepatectomies were performed in 31 patients with malignant neoplasm. Patients were distributed as: Group 1 - colorectal metastases (n=14); Group 2 - hepatocellular carcinoma (n=8); and Group 3 - non-colorectal metastases and intrahepatic cholangiocarcinoma (n=9)...
July 2017: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/28984386/pyogenic-liver-abscess-related-to-intrahepatic-bile-duct-stones-difficulties-in-infectious-control-and-diagnosis-of-concomitant-cholangiocarcinoma
#6
Shao-Hua Shi, Xiao-Ning Feng, Zhuo-Yi Wang, Ke Sun, Jing-Feng Xu, Hai-Shen Kong, Shu-Sen Zheng
BACKGROUND AND AIM: Cholangitis, bacteremia and pyogenic liver abscess (PLA) can be often caused by intrahepatic bile ducts stone (IBDS), which is endemic to Southeast Asia. The association between IBDS and cholangiocarcinoma has been well recognized. Concomitant cholangiocarcinoma in the PLA related to IBDS is often missed. METHODS: A case-control study consisting of 64 patients with PLA related to IBDS and 256 control patients with PLA not related to IBDS was used to investigate clinical features of PLA and incidence of concomitant cholangiocarcinoma in patients with PLA related to IBDS...
October 6, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28982905/immunohistochemical-comparison-of-malignancy-between-radial-invasion-and-mucosal-extension-in-hilar-cholangiocarcinoma
#7
COMPARATIVE STUDY
Kenichi Yoshida, Ryusei Matsuyama, Ryutaro Mori, Takafumi Kumamoto, Kenichi Matsuo, Kazuhisa Takeda, Mitsutaka Sugita, Yoshiro Fujii, Kuniya Tanaka, Hiroshi Shimada, Itaru Endo
AIM: To compare the cells of mucosal extension (ME) and radial invasion (RI) in hilar cholangiocarcinoma (HCCA) for optimal resection. MATERIALS AND METHODS: Forty-six patients underwent surgery for HCCA between 1992 and 2004. Immunohistochemical expressions of p53, Ki-67, matrix metalloproteinase-7 (MMP7), mucin 1 (MUC1), and E-cadherin were assessed at five different sites of the tumour and compared between the recurrence and non-recurrence groups. RESULTS: Expression of E-cadherin was significantly lower in RI cells than in ME cells, and that of MMP7 and MUC1 was significantly higher in RI cells than in ME cells...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28978591/digital-lesion-leading-to-diagnosis-of-cholangiocarcinoma
#8
Dhauna Karam, Bharat Agrawal, Chandra Mouli
Cholangiocarcinomas (CCA) are uncommon malignancies that present late and have a poor prognosis. The patients may remain undiagnosed for many years because of non-specific presentation. CCA metastasises commonly to liver and adjacent lymph nodes. It can rarely metastasise to bone, lung, colon, pancreas, adrenal glands and spleen. Multiple treatment options are available including surgery, chemotherapy, radiotherapy and photodynamic therapy. The tumours have high rate of recurrence and most patients require palliative care...
October 4, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28975832/systemic-and-adjuvant-therapies-for-intrahepatic-cholangiocarcinoma
#9
Yun Shin Chun, Milind Javle
Intrahepatic cholangiocarcinoma represents the second most common primary liver cancer and is increasing in incidence. Most patients are diagnosed at an advanced, nonsurgical stage and only about 1 in 5 cases are surgically resectable. Despite surgery, the 5-year survival is low at only 30%. Multifocal, node- or margin-positive disease is at a higher risk of recurrence after resection. There is no level 1 evidence in support of postoperative adjuvant therapy. A recent adjuvant therapy phase III trial from the Partenariat de Recherche en Oncologie Digestive-Actions Concertées dans les Cancers Colo-Rectaux et Digestifs (PRODIGE) group reported no survival advantage with adjuvant gemcitabine and oxaliplatin therapy...
July 2017: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/28945626/c-reactive-protein-crp-is-a-promising-diagnostic-immunohistochemical-marker-for-intrahepatic-cholangiocarcinoma-and-is-associated-with-better-prognosis
#10
Yi-Chen Yeh, Hao-Jan Lei, Ming-Huang Chen, Hsiang-Ling Ho, Ling-Ya Chiu, Chung-Pin Li, Yu-Chao Wang
Differential diagnosis of intrahepatic cholangiocarcinoma (iCCA) from its histologic mimickers, especially metastatic adenocarcinomas of gastric and pancreatic origin, is a great challenge for pathologists. In this study, through bioinformatics analysis of data from The Cancer Genome Atlas and Gene Expression Omnibus, we identified C-reactive protein (CRP) as a candidate marker to differentiate iCCA from other adenocarcinomas and validated its diagnostic performance by immunohistochemistry in a large cohort of clinical samples including 103 iCCAs, 384 other adenocarcinomas, and 34 liver metastases of various origins...
September 22, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28940411/the-impact-of-perioperative-ca19-9-change-on-the-survival-and-recurrence-patterns-after-adjuvant-chemoradiotherapy-in-resectable-extrahepatic-cholangiocarcinoma
#11
Byoung Hyuck Kim, Eunji Kim, Kyubo Kim, Jin-Young Jang, Sun Whe Kim, Do-Youn Oh, Eui Kyu Chie
BACKGROUNDS: Perioperative CA19-9 value in pancreato-biliary cancers has been recognized as a prognostic factor. Herein, we investigated survival differences and recurrence patterns after adjuvant chemoradiotherapy by perioperative CA19-9 change in surgically resected extrahepatic cholangiocarcinoma. METHODS: Patients were divided into those with preoperative normal CA19-9 (Group 1, n = 52), those with high preoperative and normalized postoperative CA19-9 (Group 2, n = 80), and those with both high pre- and postoperative CA19-9 (Group 3, n = 21)...
September 20, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28919993/tumor-necrosis-and-infiltrating-macrophages-predict-survival-after-curative-resection-for-cholangiocarcinoma
#12
Georgi Atanasov, Corinna Dietel, Linda Feldbrügge, Christian Benzing, Felix Krenzien, Andreas Brandl, Elli Mann, Julianna Paulina Englisch, Katrin Schierle, Simon C Robson, Katrin Splith, Mehmet Haluk Morgul, Anja Reutzel-Selke, Sven Jonas, Andreas Pascher, Marcus Bahra, Johann Pratschke, Moritz Schmelzle
Background. Tumor necrosis as well as tumor-associated macrophages (TAMs) in the tumor invasive front (TIF) have been suggested to have a prognostic value in selected solid tumors, inclusive hilar cholangiocarcinoma. However, little is known regarding their influence on tumor progression and prognosis in intrahepatic cholangiocarcinoma (iCC). Methods. We analyzed surgically resected tumor specimens of human iCC (n = 88) for distribution and localization of TAMs, as defined by expression of CD68, formation of necrosis and extent of peritumoral fibrosis...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28917216/mass-forming-intrahepatic-cholangiocarcinoma-with-portal-vein-tumor-thrombus-and-bile-duct-tumor-thrombus-a-case-report
#13
Kentaro Iwaki, Toshimi Kaido, Gen Yamamoto, Naoko Kamo, Shintaro Yagi, Kojiro Taura, Shinji Uemoto
INTRODUCTION: We report the first case of mass-forming intrahepatic cholangiocarcinoma (ICC) with portal vein tumor thrombus (PVTT) and bile duct tumor thrombus (BDTT), where the extrahepatic bile duct was preserved with thrombectomy. PRESENTATION OF CASE: A 70-year-old male. Magnetic resonance imaging (MRI) showed the tumor extending from the hepatic hilum to the left hepatic duct with complete obstruction of the left hepatic duct and a defect at the left portal vein...
September 8, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28913712/surgical-site-infection-is-associated-with-tumor-recurrence-in-patients-with-extrahepatic-biliary-malignancies
#14
Stefan Buettner, Cecilia G Ethun, George Poultsides, Thuy Tran, Kamran Idrees, Chelsea A Isom, Matthew Weiss, Ryan C Fields, Bradley Krasnick, Sharon M Weber, Ahmed Salem, Robert C G Martin, Charles R Scoggins, Perry Shen, Harveshp D Mogal, Carl Schmidt, Eliza Beal, Ioannis Hatzaras, Rivfka Shenoy, Bas Groot Koerkamp, Shishir K Maithel, Timothy M Pawlik
BACKGROUND: Surgical site infections (SSI) are one of the most common complications after hepato-pancreato-biliary surgery. Infectious complications may lead to an associated immune-modulatory effect that inhibits the body's response to cancer surveillance. We sought to define the impact of SSI on long-term prognosis of patients undergoing surgical resection of extrahepatic biliary malignancies (EHBM). METHODS: Patients undergoing surgery for EHBM between 2000 and 2014 were identified using a large, multi-center, national cohort dataset...
September 14, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28902667/the-liver-tunnel-intention-to-treat-validation-of-a-new-type-of-hepatectomy
#15
Guido Torzilli, Fabio Procopio, Luca Viganò, Guido Costa, Andrea Fontana, Matteo Cimino, Matteo Donadon, Daniele Del Fabbro
OBJECTIVE: This prospective intention-to-treat validation study evaluated the liver tunnel (LT) technique for patients having ≥1 deep centrally located liver tumor, with or without middle hepatic vein (MHV) invasion. BACKGROUND: Conservative surgery has been proposed for patients with deep liver tumors having complex relationships. LT is one such novel technique. METHODS: Eligible patients were prospectively enrolled for LT. LT relies on tumor-vessel detachment, and the presence of communicating veins if MHV resection is necessary...
September 11, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28879598/implications-of-intrahepatic-cholangiocarcinoma-etiology-on-recurrence-and-prognosis-after-curative-intent-resection-a-multi-institutional-study
#16
Xu-Feng Zhang, Jeffery Chakedis, Fabio Bagante, Eliza W Beal, Yi Lv, Matthew Weiss, Irinel Popescu, Hugo P Marques, Luca Aldrighetti, Shishir K Maithel, Carlo Pulitano, Todd W Bauer, Feng Shen, George A Poultsides, Oliver Soubrane, Guillaume Martel, B Groot Koerkamp, Alfredo Guglielmi, Endo Itaru, Timothy M Pawlik
BACKGROUND: We sought to investigate the prognosis of patients following curative-intent surgery for intrahepatic cholangiocarcinoma (ICC) stratified by hepatitis B (HBV-ICC), hepatolithiasis (Stone-ICC), and no identifiable cause (conventional ICC) etiologic subtype. METHODS: 986 patients with HBV-ICC (n = 201), stone-ICC (n = 103), and conventional ICC (n = 682) who underwent curative-intent resection were identified from a multi-institutional database. Propensity score matching (PSM) was used to mitigate residual bias...
September 6, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28875398/total-hilar-en-bloc-resection-with-left-hemihepatectomy-and-caudate-lobectomy-a-novel-approach-for-treatment-of-left-sided-perihilar-cholangiocarcinoma-with-video
#17
Cai De Lu, Jing Huang, Sheng Dong Wu, Yong Fei Hua, Ammar A Javed, Jiong Zhe Fang, Chun Nian Wang, Sheng Ye
BACKGROUND: "Hilar en bloc resection" using a no-touch technique has been advocated as a standard procedure in right-sided hepatectomies for treatment of perihilar cholangiocarcinoma (PHC). In principle, it has never been reported for left-sided tumors. The aim is to describe the procedures of total hilar en bloc resection with left hemihepatectomy and caudate lobectomy (THER-LH) for advanced PHC and discuss feasibility and clinical significance of this novel technique. METHODS: A retrospective study using a prospectively maintained database was performed to identify eight patients who had received THER-LH for advanced PHC from January 2013 to December 2015...
September 5, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28845114/outcome-and-evaluation-of-prognostic-factors-after-pancreaticoduodenectomy-for-distal-cholangiocarcinoma
#18
Johannes Byrling, Roland Andersson, Agata Sasor, Gert Lindell, Daniel Ansari, Johan Nilsson, Bodil Andersson
BACKGROUND: The aim of the present study was to examine the outcomes and prognostic factors after surgery with curative intent for distal cholangiocarcinoma during a modern timespan, in a Swedish tertiary referral center. METHODS: All patients who underwent pancreaticoduodenectomy for distal cholangiocarcinoma between April 2008 and December 2015 were identified. Survival was estimated using the Kaplan-Meier analysis. Demographic, clinical, laboratory and histopathological data were evaluated for prognostic factors relating to mortality, using univariable and multivariable statistical analysis...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/28808500/emerging-molecular-targets-and-therapy-for-cholangiocarcinoma
#19
REVIEW
Hamzeh Kayhanian, Elizabeth C Smyth, Chiara Braconi
Cholangiocarcinoma (CCA) is a rare cancer arising from the biliary tree with a poor prognosis and limited therapeutic options. Recent large scale molecular characterisation studies have identified recurrent genetic alterations in CCA which may be amenable to therapeutic targeting. In this review we explore the genomic landscape of CCA and examine results from trials of molecularly targeted agents and immunotherapy in this disease. Challenges in CCA diagnosis, treatment and trial design are discussed and we reflect on future directions which may lead to improved outcomes for CCA patients...
July 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28802875/primary-sclerosing-cholangitis-a-comprehensive-review
#20
REVIEW
Tom H Karlsen, Trine Folseraas, Douglas Thorburn, Mette Vesterhus
Primary sclerosing cholangitis (PSC) is a rare disorder characterised by multi-focal bile duct strictures and progressive liver disease. Inflammatory bowel disease is usually present and there is a high risk of cholangiocarcinoma and colorectal cancer. Most patients ultimately require liver transplantation, after which disease recurrence may occur. With limited therapeutic options and a lack of proven surveillance strategies, patients currently have significant unmet needs. In the present seminar, we provide a comprehensive review of the status of the field...
August 10, 2017: Journal of Hepatology
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