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Recurrant cholangiocarcinoma

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https://www.readbyqxmd.com/read/28238541/igg4-related-sclerosing-cholangitis-overlapping-with-autoimmune-hepatitis-report-of-a-case
#1
Hongyan Li, Li Sun, David R Brigstock, Lina Qi, Runping Gao
BACKGROUND: IgG4-related sclerosing cholangitis (IgG4-SC) is the biliary manifestation of IgG4-related disease (IgG4-RD) but the presence of IgG4-SC in the porta hepatis is difficult to differentiate from hilar cholangiocarcinoma (HCCA). IgG4-related autoimmune hepatitis (IgG4-related AIH) is extremely rare and it is not fully clear whether IgG4-related AIH is a hepatic manifestation of IgG4-RD or a subtype of AIH. CASE PRESENTATION: We present a rare case of a 52-year-old male who was admitted with obstructive jaundice and itchy skin...
February 10, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28229076/locoregional-therapies-of-cholangiocarcinoma
#2
REVIEW
Christof M Sommer, Hans U Kauczor, Philippe L Pereira
BACKGROUND: Cholangiocarcinoma (CC) is the second most primary liver malignancy with increasing incidence in Western countries. Currently, surgical R0 resection is regarded as the only potentially curative treatment. The results of systemic chemotherapy and best supportive care (BSC) in patients with metastatic disease are often disappointing in regard to toxicity, oncologic efficacy, and overall survival. In current practice, the use of different locoregional therapies is increasingly more accepted...
December 2016: Visceral Medicine
https://www.readbyqxmd.com/read/28229074/imaging-of-cholangiocarcinoma
#3
REVIEW
Susann-Cathrin Olthof, Ahmed Othman, Stephan Clasen, Christina Schraml, Konstantin Nikolaou, Malte Bongers
Cholangiocarcinoma (CC) is the second most common primary hepatobiliary tumour, and it is increasing in incidence. Imaging characteristics, behaviour, and therapeutic strategies in CC differ significantly, depending on the morphology and location of the tumour. In cross-sectional imaging, CCs can be classified according to the growth pattern (mass-forming, periductal infiltrating, intraductal) and the location (intrahepatic, perihilar, extrahepatic/distal). The prognosis of CC is unfavourable and surgical resection is the only curative treatment option; thus, early diagnosis (also in recurrent disease) and accurate staging including the evaluation of lymph node involvement and vascular infiltration is crucial...
December 2016: Visceral Medicine
https://www.readbyqxmd.com/read/28205184/extrahepatic-bile-duct-hepatocellular-carcinoma-due-to-recurrence-of-hematogenous-metastasis-50%C3%A2-months-after-hepatectomy
#4
Hiroyuki Kumata, Shigehito Miyagi, Keigo Murakami, Atsushi Fujio, Yasuyuki Hara, Chikashi Nakanishi, Naoki Kawagishi, Hironobu Sasano, Takashi Kamei, Noriaki Ouchi
BACKGROUND: Recurrent hepatocellular carcinoma (HCC) in the extrahepatic bile duct is rare with most cases diagnosed after manifesting sudden obstructive jaundice. Here, we report an extremely rare case of recurrent HCC in the common bile duct due to hematogenous metastasis. CASE PRESENTATION: A 66-year-old man underwent an extended left hepatectomy for HCC in the medial segment of the liver. Fifty months later, he presented with sudden obstructive jaundice. Endoscopic retrograde cholangiography showed a space-occupying lesion in the common bile duct, which was suspected as cholangiocarcinoma...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28187867/clinicopathologic-study-on-metachronous-double-cholangiocarcinomas-of-perihilar-and-subsequent-distal-bile-duct-origin
#5
Kentaro Shinohara, Yoshie Shimoyama, Tomoki Ebata, Yukihiro Yokoyama, Takashi Mizuno, Masato Nakaguro, Masato Nagino
BACKGROUND: Despite an increasing number of long-term survivors after the resection of perihilar cholangiocarcinoma, metachronous carcinoma in the remnant distal bile duct has not been well documented because of its rarity. The aim of this study was to clarify the feasibility of operative resection and the pathologic features for metachronous double cholangiocarcinomas. METHODS: Between 2003 and 2013, 6 patients underwent resections for both a primary perihilar cholangiocarcinoma and a metachronous distal cholangiocarcinoma...
February 7, 2017: Surgery
https://www.readbyqxmd.com/read/28183290/influence-of-cirrhosis-on-long-term-prognosis-after-surgery-in-patients-with-combined-hepatocellular-cholangiocarcinoma
#6
Yan-Ming Zhou, Cheng-Jun Sui, Xiao-Feng Zhang, Bin Li, Jia-Mei Yang
BACKGROUND: Little is known about the prognostic impact of cirrhosis on long-term survival of patients with combined hepatocellular-cholangiocarcinoma (cHCC-CC) after hepatic resection. The aim of this study was to elucidate the long-term outcome of hepatectomy in cHCC-CC patients with cirrhosis. METHODS: A total of 144 patients who underwent curative hepatectomy for cHCC-CC were divided into two groups: cirrhotic group (n = 91) and noncirrhotic group (n = 53). Long-term postoperative outcomes were compared between the two groups...
February 10, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28179982/spontaneous-biloma-due-to-an-intrahepatic-cholangiocarcinoma-an-extremely-rare-case-report-with-long-term-survival-and-literature-review
#7
Georgios K Georgiou, Athina Tsili, Anna Batistatou, Alexandra Papoudou-Bai, Georgios Papadopoulos, Michalis Fatouros, Georgios K Glantzounis
Cholangiocarcinomas are tumors that arise from the ductal epithelium of the intrahepatic or extra-hepatic bile ducts. Patients are usually asymptomatic or may present with weight loss, fatigue, loss of appetite and abdominal pain (intrahepatic cholangiocarcinomas) or jaundice (extra-hepatic cholangiocarcinomas). Subcapsular bile vessel rupture, due to intrahepatic cholangiocarcinoma, is an extremely rare clinical presentation, which is an emergent and potentially life-threatening complication. We report the case of a 79-year-old female patient suffering from an intrahepatic cholangiocarcinoma that completely obliterated the left main hepatic duct...
February 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28166534/prognostic-factors-associated-with-preoperative-clinicophysiological-outcomes-of-distal-cholangiocarcinoma
#8
Shuji Suzuki, Hideki Kajiyama, Mitsugi Shimoda, Jiro Shimazaki, Nobusada Koike, Nobuhiko Harada
BACKGROUND/AIMS: Although biliary tract cancer is generally associated with a high mortality rate, patients with distal cholangiocarcinoma have better prognoses, compared to those with periampullary cancer. This study aimed to determine the preoperative clinicophysiological factors predictive of survival and recurrence in patients with distal cholangiocarcinoma. METHODS: Forty-five patients (34 men) with distal cholangiocarcinoma who underwent pancreaticoduodenectomy between 2005 and 2013 were examined retrospectively at our center and associated hospitals...
February 7, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/28138968/recurrence-after-resection-with-curative-intent-for-distal-cholangiocarcinoma
#9
K Komaya, T Ebata, K Shirai, S Ohira, N Morofuji, A Akutagawa, R Yamaguchi, M Nagino
BACKGROUND: Few studies have been conducted on patterns of recurrence after resection for distal cholangiocarcinoma (DCC). The aim of this study was to investigate the incidence and pattern of recurrence after resection of DCC, and to evaluate prognostic factors for time to recurrence and recurrence-free survival (RFS). METHODS: Patients who underwent pancreatoduodenectomy with curative intent for DCC between 2001 and 2010 at one of 30 hospitals in Japan were reviewed retrospectively, with special attention to recurrence patterns...
January 31, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28133337/-a-case-of-peritoneal-dissemination-of-hilar-cholangiocarcinoma-presenting-with-hematuria-six-years-after-radical-surgery
#10
Noriaki Koizumi, Yuen Nakase, Hiroki Kobayashi, Tsuyoshi Takagi, Kanehisa Fukumoto
A 76-year-old man underwent radical surgery for Stage IV a hilar cholangiocarcinoma in July 2009, and had been followed at an outpatient clinic. Although no apparent recurrent lesion was detected by PET/CT examination, an elevated CA19-9 level was found in January 2014. He was then started on the oral anticancer drug S-1. However, his CA19-9 level increased gradually. The patient presented to a urological department with a complaint of macrohematuria in May 2015. Detailed examination revealed a mass lesion at the top of the urinary bladder, which was suspected to be peritoneal dissemination of the known hilar cholangiocarcinoma invading the urinary bladder wall...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133229/-lymph-node-recurrence-of-small-cell-carcinoma-of-the-extrahepatic-bile-ducts-effectively-treated-with-cisplatin-plus-irinotecan-chemotherapy-report-of-a-case
#11
Tomohiro Katada, Jun Sakata, Takuya Ando, Daiki Soma, Kizuki Yuza, Koji Toge, Yuki Hirose, Hirosuke Ishikawa, Kohei Miura, Taku Ohashi, Kazuyasu Takizawa, Kabuto Takano, Takashi Kobayashi, Hitoshi Kameyama, Toshifumi Wakai
A 78-year-old man with jaundice was diagnosed with perihilar cholangiocarcinoma(Bismuth type I ). After endoscopic biliary drainage for jaundice, a subtotal stomach-preserving pancreaticoduodenectomy was performed. Histologic examination and immunohistochemical staining with chromogranin A, synaptophysin, and CD56 resulted in a diagnosis of small cell carcinoma. Of the 18 dissected lymph nodes, 8 nodes contained a metastatic tumor. Left supraclavicular and paraaortic lymph node metastases were detected by computed tomography 5 months after the resection...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133124/-surgical-resection-after-gemcitabine-plus-cisplatin-chemotherapy-for-intrahepatic-cholangiocarcinoma-with-multiple-lymph-node-metastases-report-of-a-case
#12
Takahiro Otani, Jun Sakata, Hitoshi Kameyama, Ayaka Otani, Yuki Hirose, Hiroshi Tamura, Yuta Morimoto, Kohei Miura, Kei Yoshino, Tomoki Kido, Takashi Kobayashi, Kazuhiko Endo, Toshifumi Wakai
An 82-year-old man with upper abdominal pain was referred to our hospital because of an elevated serum CEA level and dilatation of the intrahepatic bile ducts on ultrasonography.Computed tomography revealed a hypovascular mass measuring 5.0 cm in size in the lateral section, dilatation of the peripheral intrahepatic bile ducts, and swollen lymph nodes around the lesser curvature of the stomach, the common hepatic artery, and the paraaorta.He was diagnosed with unresectable intrahepatic cholangiocarcinoma, and he received chemotherapy with biweekly gemcitabine plus cisplatin...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28124125/impact-of-incidental-misdiagnosed-intrahepatic-cholangiocarcinoma-and-combined-hepatocellular-cholangiocarcinoma-on-the-outcomes-of-liver-transplantation-an-institutional-case-series-and-literature-review
#13
REVIEW
Rahul Gupta, Junichi Togashi, Nobuhisa Akamatsu, Yoshihiro Sakamoto, Norihiro Kokudo
Intrahepatic cholangiocarcinoma (ICC) or combined hepatocellular cholangiocarcinoma (cHCC-CC) is considered to be contraindications for liver transplantation (LT); however, recent studies have shown that the outcomes of LT in small incidental ICC/cHCC-CC tumors are comparable to those in HCC. Studies reporting the survival outcome of patient(s) undergoing LT and found to have incidental or misdiagnosed ICC and/or cHCC-CC in liver explants were reviewed. Our institutional data were also included in the review analysis...
January 25, 2017: Surgery Today
https://www.readbyqxmd.com/read/28123170/clinicopathological-features-and-prognosis-of-intrahepatic-cholangiocarcinoma-after-liver-transplantation-and-resection
#14
Dong-Hwan Jung, Shin Hwang, Gi-Won Song, Chul-Soo Ahn, Deok-Bog Moon, Ki-Hun Kim, Tae-Yong Ha, Gil-Chun Park, Seung-Mo Hong, Wan-Jun Kim, Woo-Hyoung Kang, Seok-Hwan Kim, Eun Sil Yu, Sung-Gyu Lee
BACKGROUND Intrahepatic cholangiocarcinoma (ICC) can be incidentally diagnosed after liver transplantation (LT). We investigated the clinicopathological features of LT recipients with ICC and compared prognosis with that of the control group. MATERIAL AND METHODS We identified 16 recipients with ICC in our institutional database. The propensity score-matched control group comprised 100 ICC patients who underwent hepatic resection (HR). RESULTS ICC incidence was 0.5% in all adult LT patients and 1.2% in adult recipients with primary liver cancer...
January 26, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/28110453/update-on-the-diagnosis-and-treatment-of-cholangiocarcinoma
#15
REVIEW
Bryan Doherty, Vinod E Nambudiri, William C Palmer
PURPOSE OF REVIEW: Cholangiocarcinoma is a rare biliary adenocarcinoma associated with poor outcomes. Cholangiocarcinoma is subdivided into extrahepatic and intrahepatic variants. Intrahepatic cholangiocarcinoma is then further differentiated into (1) peripheral mass-forming tumors and (2) central periductal infiltrating tumors. We aimed to review the currently known risk factors, diagnostic tools, and treatment options, as well as highlight the need for further clinical trials and research to improve overall survival rates...
January 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28108099/risk-stratification-and-prognostic-nomogram-for-post-recurrence-overall-survival-in-patients-with-recurrent-extrahepatic-cholangiocarcinoma
#16
Byoung Hyuck Kim, Kyubo Kim, Eui Kyu Chie, Jeanny Kwon, Jin-Young Jang, Sun Whe Kim, Do-Youn Oh, Yung-Jue Bang
BACKGROUND: This study aimed to investigate post-recurrence overall survival (PROS) in patients with recurrent extrahepatic cholangiocarcinoma (EHC) and to indicate which groups of patients need active salvage treatments. METHODS: We retrospectively reviewed the records of 251 consecutive patients who underwent curative surgery followed by adjuvant chemoradiotherapy for EHC. Among these, 144 patients experienced a recurrence and were included for further analysis...
January 17, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28105527/pulmonary-metastasis-after-resection-of-cholangiocarcinoma-incidence-resectability-and-survival
#17
Mihoko Yamada, Tomoki Ebata, Yukihiro Yokoyama, Tsuyoshi Igami, Gen Sugawara, Takashi Mizuno, Junpei Yamaguchi, Masato Nagino
BACKGROUND: There are few reports on pulmonary metastasis from cholangiocarcinoma; therefore, its incidence, resectability, and survival are unclear. METHODS: Patients who underwent surgical resection for cholangiocarcinoma, including intrahepatic, perihilar, and distal cholangiocarcinoma were retrospectively reviewed, and this study focused on patients with pulmonary metastasis. RESULTS: Between January 2003 and December 2014, 681 patients underwent surgical resection for cholangiocarcinoma...
January 19, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28096273/mortalin-promotes-cell-proliferation-and-epithelial-mesenchymal-transition-of-intrahepatic-cholangiocarcinoma-cells-in-vitro
#18
Qiang Kang, Jia-Bin Cai, Rui-Zhao Dong, Li-Xin Liu, Chi Zhang, Peng-Fei Zhang, Hao Zou, Nan Xie, Lu Zhang, Xin-Yu Zhang, Zheng-Ji Song, Zhao-Ru Dong, Mei-Yu Hu, Xiao-Yong Huang, Xiao-Wen Zhang, Ai-Wu Ke, Guo-Ming Shi
AIMS: The prognosis of patients with intrahepatic cholangiocarcinoma (ICC) remains poor in terms of overall survival (OS) and recurrence rate. Mortalin, a stress chaperone, has been reported to be involved in carcinogenesis and metastasis. However, its role in ICC has not been defined. METHODS: Mortalin expression in tumour samples from patients with ICC was examined by Western blot and immunohistochemistry, and correlation between its expression and clinicopathological features was assessed...
January 17, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28081592/primary-adenosquamous-carcinoma-of-the-liver-a-case-report
#19
Kyung Han Nam, Ji Yeon Kim
Adenosquamous carcinoma of the liver is a rare variant of cholangiocarcinoma. It is known to be a highly aggressive tumor with a poor prognosis, but its pathogenesis remains unclear owing to limited data in the literature. We report a case of 56-year-old woman who presented with a 1-week history of epigastric pain. Magnetic resonance imaging revealed a 6.5-cm ill-defined mass with low signal intensity in the left lobe of the liver, which was suspicious of cholangiocarcinoma. The patient underwent left hemihepatectomy...
December 2016: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/28078380/imaging-features-of-hepatic-sarcomatous-carcinoma-on-computed-tomography-and-gadoxetic-acid-enhanced-magnetic-resonance-imaging
#20
Kyo-Won Gu, Young Kon Kim, Ji Hye Min, Sang Yun Ha, Woo Kyoung Jeong
PURPOSE: To determine the imaging features of hepatic sarcomatous carcinoma including sarcomatous intrahepatic cholangiocarcinoma (S-ICC) and sarcomatous hepatocellular carcinoma (S-HCC) on computed tomography (CT) and gadoxetic acid-enhanced magnetic resonance imaging (MRI). MATERIALS AND METHODS: Twenty-four patients with pathologically confirmed S-ICCs (n = 13), S-HCCs (n = 7), sarcomatous carcinoma (n = 2), carcinosarcoma (n = 1), and sarcomatous combined HCC-CC (n = 1) (size range 2...
January 12, 2017: Abdominal Radiology
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