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Recurrant cholangiocarcinoma

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https://www.readbyqxmd.com/read/28110453/update-on-the-diagnosis-and-treatment-of-cholangiocarcinoma
#1
REVIEW
Bryan Doherty, Vinod E Nambudiri, William C Palmer
PURPOSE OF REVIEW: Cholangiocarcinoma is a rare biliary adenocarcinoma associated with poor outcomes. Cholangiocarcinoma is subdivided into extrahepatic and intrahepatic variants. Intrahepatic cholangiocarcinoma is then further differentiated into (1) peripheral mass-forming tumors and (2) central periductal infiltrating tumors. We aimed to review the currently known risk factors, diagnostic tools, and treatment options, as well as highlight the need for further clinical trials and research to improve overall survival rates...
January 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28108099/risk-stratification-and-prognostic-nomogram-for-post-recurrence-overall-survival-in-patients-with-recurrent-extrahepatic-cholangiocarcinoma
#2
Byoung Hyuck Kim, Kyubo Kim, Eui Kyu Chie, Jeanny Kwon, Jin-Young Jang, Sun Whe Kim, Do-Youn Oh, Yung-Jue Bang
BACKGROUND: This study aimed to investigate post-recurrence overall survival (PROS) in patients with recurrent extrahepatic cholangiocarcinoma (EHC) and to indicate which groups of patients need active salvage treatments. METHODS: We retrospectively reviewed the records of 251 consecutive patients who underwent curative surgery followed by adjuvant chemoradiotherapy for EHC. Among these, 144 patients experienced a recurrence and were included for further analysis...
January 17, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28105527/pulmonary-metastasis-after-resection-of-cholangiocarcinoma-incidence-resectability-and-survival
#3
Mihoko Yamada, Tomoki Ebata, Yukihiro Yokoyama, Tsuyoshi Igami, Gen Sugawara, Takashi Mizuno, Junpei Yamaguchi, Masato Nagino
BACKGROUND: There are few reports on pulmonary metastasis from cholangiocarcinoma; therefore, its incidence, resectability, and survival are unclear. METHODS: Patients who underwent surgical resection for cholangiocarcinoma, including intrahepatic, perihilar, and distal cholangiocarcinoma were retrospectively reviewed, and this study focused on patients with pulmonary metastasis. RESULTS: Between January 2003 and December 2014, 681 patients underwent surgical resection for cholangiocarcinoma...
January 19, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28096273/mortalin-promotes-cell-proliferation-and-epithelial-mesenchymal-transition-of-intrahepatic-cholangiocarcinoma-cells-in-vitro
#4
Qiang Kang, Jia-Bin Cai, Rui-Zhao Dong, Li-Xin Liu, Chi Zhang, Peng-Fei Zhang, Hao Zou, Nan Xie, Lu Zhang, Xin-Yu Zhang, Zheng-Ji Song, Zhao-Ru Dong, Mei-Yu Hu, Xiao-Yong Huang, Xiao-Wen Zhang, Ai-Wu Ke, Guo-Ming Shi
AIMS: The prognosis of patients with intrahepatic cholangiocarcinoma (ICC) remains poor in terms of overall survival (OS) and recurrence rate. Mortalin, a stress chaperone, has been reported to be involved in carcinogenesis and metastasis. However, its role in ICC has not been defined. METHODS: Mortalin expression in tumour samples from patients with ICC was examined by Western blot and immunohistochemistry, and correlation between its expression and clinicopathological features was assessed...
January 17, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28081592/primary-adenosquamous-carcinoma-of-the-liver-a-case-report
#5
Kyung Han Nam, Ji Yeon Kim
Adenosquamous carcinoma of the liver is a rare variant of cholangiocarcinoma. It is known to be a highly aggressive tumor with a poor prognosis, but its pathogenesis remains unclear owing to limited data in the literature. We report a case of 56-year-old woman who presented with a 1-week history of epigastric pain. Magnetic resonance imaging revealed a 6.5-cm ill-defined mass with low signal intensity in the left lobe of the liver, which was suspicious of cholangiocarcinoma. The patient underwent left hemihepatectomy...
December 2016: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/28078380/imaging-features-of-hepatic-sarcomatous-carcinoma-on-computed-tomography-and-gadoxetic-acid-enhanced-magnetic-resonance-imaging
#6
Kyo-Won Gu, Young Kon Kim, Ji Hye Min, Sang Yun Ha, Woo Kyoung Jeong
PURPOSE: To determine the imaging features of hepatic sarcomatous carcinoma including sarcomatous intrahepatic cholangiocarcinoma (S-ICC) and sarcomatous hepatocellular carcinoma (S-HCC) on computed tomography (CT) and gadoxetic acid-enhanced magnetic resonance imaging (MRI). MATERIALS AND METHODS: Twenty-four patients with pathologically confirmed S-ICCs (n = 13), S-HCCs (n = 7), sarcomatous carcinoma (n = 2), carcinosarcoma (n = 1), and sarcomatous combined HCC-CC (n = 1) (size range 2...
January 12, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28076328/albumin-to-gamma-glutamyltransferase-ratio-as-a-prognostic-indicator-in-intrahepatic-cholangiocarcinoma-after-curative-resection
#7
Chu-Yu Jing, Yi-Peng Fu, Hu-Jia Shen, Su-Su Zheng, Jia-Jia Lin, Yong Yi, Jin-Long Huang, Xin Xu, Juan Zhang, Jian Zhou, Jia Fan, Zheng-Gang Ren, Shuang-Jian Qiu, Bo-Heng Zhang
The prognosis of intrahepatic cholangiocarcinoma (ICC) remains poor whereas predictive models for survival prediction in ICC patients following curative resection are limited. Herein, we established a novel inflammation-based score derived from preoperative albumin to gamma-glutamyltransferase ratio (AGR) and evaluated its prognostic significance in ICC patients underwent curative resection. Prognostic value of AGR was retrospectively studied in a cohort comprising 206 ICC patients following curative resection...
January 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28062160/loss-of-secreted-frizzled-related-protein-1-expression-is-associated-with-poor-prognosis-in-intrahepatic-cholangiocarcinoma
#8
M Davaadorj, Y Saito, Y Morine, T Ikemoto, S Imura, C Takasu, S Yamada, T Hiroki, M Yoshikawa, M Shimada
AIMS: Secreted Frizzled-Related Protein-1 (SFRP1) is a well-known negative regulator of the wingless type (Wnt)-β-catenin pathway and its inactivation plays an important role in the development and progression of many cancers. In this study, we aimed to determine the clinical significance of SFRP1 expression in intrahepatic cholangiocarcinoma (IHCC) and to define the relationship to Wnt-β-catenin pathway. METHODS: Fifty IHCC patients who had liver resection were enrolled in this study...
December 24, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28058554/prognosis-of-intrahepatic-cholangiocarcinomas-with-hbv-infection-is-better-than-those-with-hepatolithiasis-after-r0-liver-resection-a-propensity-score-matching-analysis
#9
Qing Wang, Jun Li, Zhengqing Lei, Dong Wu, Anfeng Si, Kui Wang, Yizhou Wang, Xuying Wan, Wan Yee Lau, Feng Shen
BACKGROUND: The impact of different causative factors of intrahepatic cholangiocarcinoma (ICC) on disease outcome remains largely unknown. This study aimed to evaluate the prognosis of ICC patients with different pathogenic factors after hepatectomy. METHODS: Data of 731 consecutive patients undergoing R0 liver resection for ICC at The Eastern Hepatobiliary Surgery Hospital between 2004 and 2010 were analyzed. These patients were divided into the hepatitis B virus-related (HBV-ICC, n = 519), hepatolithiasis-related (stone-ICC, n = 87), HBV plus hepatolithiasis-related (HBV/stone-ICC, n = 45), and other etiologies-related (other-ICC, n = 80) ICC groups...
January 5, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28034880/polyclonal-secondary-fgfr2-mutations-drive-acquired-resistance-to-fgfr-inhibition-in-patients-with-fgfr2-fusion-positive-cholangiocarcinoma
#10
Lipika Goyal, Supriya K Saha, Leah Y Liu, Giulia Siravegna, Ignaty Leshchiner, Leanne G Ahronian, Jochen K Lennerz, Phuong Vu, Vikram Deshpande, Avinash Kambadakone, Benedetta Mussolin, Stephanie Reyes, Laura Henderson, Jiaoyuan Elisabeth Sun, Emily E Van Seventer, Joseph M Gurski, Sabrina Baltschukat, Barbara Schacher-Engstler, Louise Barys, Christelle Stamm, Pascal Furet, David P Ryan, James R Stone, A John Iafrate, Gad Getz, Diana Graus Porta, Ralph Tiedt, Alberto Bardelli, Dejan Juric, Ryan B Corcoran, Nabeel Bardeesy, Andrew X Zhu
Genetic alterations in the fibroblast growth factor receptor (FGFR) pathway are promising therapeutic targets in many cancers, including intrahepatic cholangiocarcinoma (ICC). The FGFR inhibitor BGJ398 displayed encouraging efficacy in patients with FGFR2 fusion-positive ICC in a phase II trial, but the durability of response was limited in some patients. Here, we report the molecular basis for acquired resistance to BGJ398 in three patients via integrative genomic characterization of cell-free circulating tumor DNA (cfDNA), primary tumors, and metastases...
December 29, 2016: Cancer Discovery
https://www.readbyqxmd.com/read/28032221/can-laparoscopic-liver-resection-provide-a-favorable-option-for-patients-with-large-or-multiple-intrahepatic-cholangiocarcinomas
#11
Fangqiang Wei, Chen Lu, Liuxin Cai, Hong Yu, Xiao Liang, Xiujun Cai
BACKGROUND: The role of laparoscopic liver resection (LLR) for large or multiple intrahepatic cholangiocarcinomas (ICCs) remains equivocal. The main concerns are potential risks of inadequate resection margin, tumor rupture, uncontrollable bleeding, tumor seeding, and inadequate lymph node sampling. In this study, we aimed to determine the safety, feasibility, and oncological efficacy of LLR for large (≥5 cm) or multiple (≥2) ICCs. METHODS: Among 50 patients receiving liver resection for ICC between May 2004 and January 2016, 12 patients who had undergone LLR for large or multiple ICCs (Group A, n = 12) were compared with 18 patients who had undergone LLR for small solitary ICCs (Group B, n = 18), as well were compared with 20 patients who had undergone open liver resection for large or multiple ICCs (Group C, n = 20)...
December 28, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/28027599/long-term-prognosis-of-combined-hepatocellular-carcinoma-cholangiocarcinoma-following-liver-transplantation-and-resection
#12
Dong-Hwan Jung, Shin Hwang, Gi-Won Song, Chul-Soo Ahn, Deok-Bog Moon, Ki-Hun Kim, Tae-Yong Ha, Gil-Chun Park, Seung-Mo Hong, Wan-Jun Kim, Woo-Hyoung Kang, Seok- Hwan Kim, Eun Sil Yu, Sung-Gyu Lee
Combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC) is a rare disease. We investigated the clinicopathological features of cHCC-CC and compared the long-term outcomes following liver transplantation (LT) and hepatic resection (HR). We identified 32 LT patients with cHCC-CC through an institutional database search. HR control group (n=100) was selected through propensity score-matching. The incidence of cHCC-CC among all adult LT cases was 1.0%. Mean patient age was 53.4±6.7 years and 26 patients were male...
December 27, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/28012034/surgical-treatment-of-perihilar-cholangiocarcinoma-early-results-of-en-bloc-portal-vein-resection
#13
Víctor Molina, Jaime Sampson, Joana Ferrer, Alba Díaz, Juan Ramon Ayuso, Santiago Sánchez-Cabús, Josep Fuster, Juan Carlos García-Valdecasas
OBJECTIVE: The objective of this study was to analyse the safety, feasibility and survival outcomes of our treatment of perihilar cholangiocarcinoma (PHC) since the introduction of more aggressive approaches (en bloc, vascular and extended liver resections) in 2007. PATIENTS AND METHODS: From July 2007 to December 2014, 32 consecutive patients with PHC underwent surgery with curative intent. Surgery with resection and reconstruction of the portal vein bifurcation and right hepatic artery was performed if necessary for a complete removal of the tumour...
December 23, 2016: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/27989605/effectiveness-of-repeat-hepatic-resection-for-patients-with-recurrent-intrahepatic-cholangiocarcinoma-factors-associated-with-long-term-outcomes
#14
Anfeng Si, Jun Li, Xianglei Xing, Zhengqing Lei, Yong Xia, Zhenlin Yan, Kui Wang, Lehua Shi, Feng Shen
BACKGROUND: Tumor recurrence after liver resection for intrahepatic cholangiocarcinoma is common. The effective treatment for recurrent intrahepatic cholangiocarcinoma remains to be established. This study evaluated the short- and long-term prognoses of patients after repeat hepatic resection for recurrent intrahepatic cholangiocarcinoma. METHODS: Data for 72 patients who underwent R0 repeat hepatic resection for recurrent intrahepatic cholangiocarcinoma at the Eastern Hepatobiliary Surgery Hospital between 2005 and 2013 were analyzed...
December 15, 2016: Surgery
https://www.readbyqxmd.com/read/27959300/cholestatic-liver-injury-care-of-patients-with-primary-biliary-cholangitis-or-primary-sclerosing-cholangitis
#15
Laurie Larson, Michelle James, Andrea Gossard
The most common causes of chronic cholestatic liver disease are primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). Both disease processes are characterized by a destruction of intrahepatic and/or extrahepatic biliary ducts. The etiology is not entirely clear; however, there is an underlying autoimmune component contributing to both disease processes. Although PBC and PSC are often diagnosed and managed in the outpatient setting, in some instances, a patient may have jaundice, fatigue, and pruritus requiring evaluation and determination of the cholestatic cause...
October 2016: AACN Advanced Critical Care
https://www.readbyqxmd.com/read/27957635/gadoxetic-acid-enhanced-magnetic-resonance-imaging-characteristics-of-hepatocellular-carcinoma-occurring-in-liver-transplants
#16
Mimi Kim, Tae Wook Kang, Woo Kyoung Jeong, Young Kon Kim, Seong Hyun Kim, Jong Man Kim, Dong Hyun Sinn, Min-Ji Kim, Sin-Ho Jung
OBJECTIVES: Characteristics of hepatocellular carcinoma (HCC) on magnetic resonance (MR) images were compared in patients who did or did not undergo liver transplantation (LT), and we evaluated the relationship of these findings with overall survival (OS) and time-to-tumour recurrence (TTR) after transplantation. METHODS: The enhancement pattern of gadoxetic acid-enhanced MR images of 25 patients with recurrent HCCs (LT group) and 25 surgically confirmed HCC patients in the non-transplanted (control) group were compared...
December 12, 2016: European Radiology
https://www.readbyqxmd.com/read/27940488/survival-of-surgery-for-recurrent-biliary-tract-cancer-a-single-center-experience-and-systematic-review-of-literature
#17
Yoshihiro Miyazaki, Takashi Kokudo, Katsumi Amikura, Yumiko Kageyama, Amane Takahashi, Nobuhiro Ohkohchi, Hirohiko Sakamoto
BACKGROUND: For recurrent biliary tract cancer, chemotherapy is the standard treatment. However, the efficacy of surgery is unknown. Here, the prognostic benefit of surgery for recurrent biliary tract cancer was investigated. METHODS: Data of 206 patients who underwent surgery for biliary tract cancer between 2005 and 2015 were retrospectively analyzed. Of these, 107 recurrent patients were divided into two groups, surgery (n = 14) and non-surgery (n = 93) groups...
December 8, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27928598/the-role-of-adjuvant-therapy-after-r0-resection-for-patients-with-intrahepatic-and-perihilar-cholangiocarcinomas
#18
Young Saing Kim, Sung Yong Oh, Se-Il Go, Jung-Hun Kang, Inkeun Park, Haa-Na Song, Jun Ho Ji, In Gyu Hwang, Joung-Soon Jang
PURPOSE: There is still debated regarding the optimal treatment strategy for cholangiocarcinoma (CC) after curative resection. The aim of this study was to analyze the role of adjuvant therapy in R0-resected intrahepatic and perihilar CCs. METHODS: We retrospectively reviewed the patients who underwent R0 resection for intrahepatic and perihilar CCs between January 2001 and December 2013 at six tertiary medical centers; adjuvant therapy consisted of chemotherapy (CT), chemoradiotherapy (CRT), or radiotherapy (RT)...
December 7, 2016: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/27928095/cholangiocarcinoma-current-knowledge-and-new-developments
#19
REVIEW
Boris Blechacz
Cholangiocarcinoma (CCA) is the second most common primary malignancy. Although it is more common in Asia, its incidence in Europe and North America has significantly increased in recent decades. The prognosis of CCA is dismal. Surgery is the only potentially curative treatment, but the majority of patients present with advanced stage disease, and recurrence after resection is common. Over the last two decades, our understanding of the molecular biology of this malignancy has increased tremendously, diagnostic techniques have evolved, and novel therapeutic approaches have been established...
January 15, 2017: Gut and Liver
https://www.readbyqxmd.com/read/27919984/clinical-significances-of-preoperative-classification-of-intrahepatic-cholangiocarcinoma-different-characteristics-of-perihilar-vs-peripheral-icc
#20
Yo-Ichi Yamashita, Huanlin Wang, Takeshi Kurihara, Eiji Tsujita, Akihiro Nishie, Katsunori Imai, Daisuke Hashimoto, Akira Chikamoto, Shinichi Aishima, Hideo Baba
BACKGROUND: The aim of this study was to evaluate the clinical significance of preoperative classification of intrahepatic cholangiocarcinoma (ICC) into perihilar and peripheral types using dynamic computed tomography (CT). PATIENTS AND METHODS: A retrospective cohort study was performed to analyze the differences in clinical characteristics between perihilar and peripheral ICC samples from patients between 1990-2014. RESULTS: A total of 87 patients were divided into three ICC subtypes; perihilar (n=34), peripheral (n=44), and unclassifiable ICC (n=9)...
2016: Anticancer Research
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