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Methamphetamine withdrawal

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https://www.readbyqxmd.com/read/27905916/study-protocol-a-dose-escalating-phase-2-study-of-oral-lisdexamfetamine-in-adults-with-methamphetamine-dependence
#1
Nadine Ezard, Adrian Dunlop, Brendan Clifford, Raimondo Bruno, Andrew Carr, Alexandra Bissaker, Nicholas Lintzeris
BACKGROUND: The treatment of methamphetamine dependence is a continuing global health problem. Agonist type pharmacotherapies have been used successfully to treat opioid and nicotine dependence and are being studied for the treatment of methamphetamine dependence. One potential candidate is lisdexamfetamine, a pro-drug for dexamphetamine, which has a longer lasting therapeutic action with a lowered abuse potential. The purpose of this study is to determine the safety of lisdexamfetamine in this population at doses higher than those currently approved for attention deficit hyperactivity disorder or binge eating disorder...
December 1, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27890469/methamphetamine-addiction-vulnerability-the-glutamate-the-bad-and-the-ugly
#2
Karen K Szumlinski, Kevin D Lominac, Rianne R Campbell, Matan Cohen, Elissa K Fultz, Chelsea N Brown, Bailey W Miller, Sema G Quadir, Douglas Martin, Andrew B Thompson, Georg von Jonquieres, Matthias Klugmann, Tamara J Phillips, Tod E Kippin
BACKGROUND: The high prevalence and severity of methamphetamine (MA) abuse demands greater neurobiological understanding of its etiology. METHODS: We conducted immunoblotting and in vivo microdialysis procedures in MA high/low drinking mice, as well as in isogenic C57BL/6J mice that varied in their MA preference/taking, to examine the glutamate underpinnings of MA abuse vulnerability. Neuropharmacological and Homer2 knockdown approaches were also used in C57BL/6J mice to confirm the role for nucleus accumbens (NAC) glutamate/Homer2 expression in MA preference/aversion...
October 13, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27865801/long-term-cognitive-emotional-and-neurogenic-alterations-induced-by-alcohol-and-methamphetamine-exposure-in-adolescent-rats
#3
David Loxton, Juan J Canales
A high proportion of young methamphetamine (MA) users simultaneously consume alcohol. However, the potential neurological and behavioural alterations induced by such a drug combination have not been systematically examined. We studied in adolescent rats the long-term effects of alcohol, MA, and alcohol and MA combined on anxiety-like behaviour, memory, and neurogenesis in the adult hippocampus. Rats received saline, ethanol (ETOH, 1.5g/kg), MA (MA, 2mg/kg), or ethanol and MA combined (ETHOH-MA, 1.5g/kg ethanol plus 2mg/kg MA) via oral gavage, once daily for 5 consecutive days...
November 16, 2016: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/27853417/a-mouse-model-for-binge-level-methamphetamine-use
#4
Shkelzen Shabani, Sydney K Houlton, Laura Hellmuth, Erika Mojica, John R K Mootz, Zhen Zhu, Cheryl Reed, Tamara J Phillips
Binge/crash cycles of methamphetamine (MA) use are frequently reported by individuals suffering from MA use disorders. A MA binge is self-reported as multiple daily doses that commonly accumulate to 800 mg/day (~10 mg/kg/day for a 170 pound human). A genetic animal model with a similar vulnerability to binge-level MA intake is missing. We used selectively bred MA high drinking (MAHDR) and low drinking (MALDR) mouse lines to determine whether several procedural variations would result in binge-level MA intake...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27846654/-synthetic-drugs-an-overview-of-important-and-newly-emerging-substances
#5
F Betzler, A Heinz, S Köhler
Background: Synthetic drug use and abuse are on the rise. Governmental institutions report a shift in consumption from natural drugs to synthetic drugs, and show an increase in confiscation, particularly of methamphetamine and newly identified psychoactive substances. In addition, the media report an alarming increase in the rate of consumption and casualties resulting from the use of drugs such as "crystal meth" and warn against a flood of this and other designer drugs from eastern European countries. Objectives: The present article gives an overview of current popular and widely used synthetic drugs, both classical substances (amphetamine, methamphetamine, MDMA) and new psychoactive substances ("designer drugs", "legal highs")...
November 2016: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/27776672/a-review-of-methamphetamine-dependence-and-withdrawal-treatment-a-focus-on-anxiety-outcomes
#6
Tracy L Hellem
Rates of anxiety disorders among individuals who use methamphetamine are estimated to be as high as 30.2%. The presence of an anxiety disorder in methamphetamine users is associated with higher rates of relapse, non-adherence to treatment and poorer outcomes relative to methamphetamine users without an anxiety disorder. A review investigating current treatment options for methamphetamine dependence or withdrawal from methamphetamine was conducted using PubMed, CINAHL and PsycINFO. The focus of the review was trials that utilized an intervention and collected anxiety as an outcome measure...
December 2016: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/27748174/positive-neonatal-urine-comprehensive-drug-screen-low-birth-weight-and-withdrawal-symptoms-in-a-neonatal-unit-a-case-control-study
#7
Kam Lun Hon, Michael Ho Ming Chan, Ming Him James Ng, Chi Cheung Ho, Yin Ching Kathy Tsang, Wing Hung Tam, Chung Shun Ho
OBJECTIVE: Maternal drug abuse may influence neonatal outcomes. We compared neonatal outcomes of patients with urine screened positive for commonly abused drugs (CAD) versus those who were screened negative, and reviewed the pattern of drugs detected at a university teaching hospital. METHODS: Urine samples collected from babies with suspected illicit drug exposure who were admitted to the neonatal unit were sent for comprehensive drug screen (CDS) performed by liquid chromatography-time-of-flight mass spectrometry (LC-TOF/MS)...
October 10, 2016: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/27736680/barriers-to-accessing-methamphetamine-treatment-a-systematic-review-and-meta-analysis
#8
Craig Cumming, Lakkhina Troeung, Jesse T Young, Erin Kelty, David B Preen
BACKGROUND: Methamphetamine use is associated with a range of poor health, social and justice outcomes. In many parts of the world increased methamphetamine use has been identified as a major public health concern. Methamphetamine treatment programmes have been effective in reducing and ceasing use, however a range of barriers have prevented these programmes being widely adopted by methamphetamine users. This review examines the barriers to accessing meth/amphetamine treatment identified in the literature...
October 6, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27734823/-ibogaine-structure-influence-on-human-body-clinical-relevance
#9
Zygmunt Zdrojewicz, Bartłomiej Kuszczak, Natalia Olszak
Ibogaine is a natural chemical compound, which belongs to the indole alkaloid family. It can be naturally found within the root bark of african plant Tabernanthe iboga. Ibogaine plays a significant role among tribal cultures. Ibogaine, in small amount, causes reduction of hunger, thirst and exhaustion. In bigger amount, however, it can cause intensive visions. Other effects include reduction or complete disappearance of absitnence symptoms visible in people addicted to the nicotine, alcohol, methamphetamine, cocaine or opioids, what has been scientifically proven after the tests on animals and small groups of people...
July 29, 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/27649265/sex-differences-in-methamphetamine-use-and-dependence-in-a-thai-treatment-center
#10
Teerayuth Rungnirundorn, Viroj Verachai, Joel Gelernter, Robert T Malison, Rasmon Kalayasiri
BACKGROUND AND OBJECTIVE: Males and females who use methamphetamine (MA) differ in sociodemographics, MA diagnoses, comorbidities, and brain activity. The objective of this study was to investigate sex differences in the characteristics of MA use and dependence in patients at a Thai substance treatment center. METHODS: Demographic, MA use, and diagnostic data for 782 MA users were obtained by using the Semi-Structured Assessment for Drug Dependence and Alcoholism-Thai version...
September 19, 2016: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/27580848/gabaergic-mrna-expression-is-differentially-expressed-across-the-prelimbic-and-orbitofrontal-cortices-of-rats-sensitized-to-methamphetamine-relevance-to-psychosis
#11
Travis A Wearne, Lindsay M Parker, Jane L Franklin, Ann K Goodchild, Jennifer L Cornish
Psychotic disorders, such as schizophrenia, are characterized by prevalent and persistent executive deficits that are believed to be the result of dysfunctional inhibitory gamma-aminobutyric acid (GABA) processing of the prefrontal cortex (PFC). Methamphetamine (METH) is a commonly used psychostimulant that can induce psychotic and cognitive symptoms that are indistinguishable to schizophrenia, suggesting that METH-induced psychosis may have a similar GABAergic profile of the PFC. As the PFC consists of multiple subregions, the aim of the current study was to investigate changes to GABAergic mRNA expression in the prelimbic (PRL) and orbitofrontal (OFC) cortices of the PFC in rats sensitized to repeated METH administration...
December 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27501345/selective-enhancement-of-dopamine-release-in-the-ventral%C3%A2-pallidum-of-methamphetamine-sensitized-mice
#12
Kristen Ann Stout, Amy R Dunn, Kelly M Lohr, Shawn P Alter, Rachel A Cliburn, Thomas S Guillot, Gary W Miller
Drugs of abuse induce sensitization, which is defined as enhanced response to additional drug following a period of withdrawal. Sensitization occurs in both humans and animal models of drug reinforcement and contributes substantially to the addictive nature of drugs of abuse, as it is thought to represent enhanced motivational wanting for drug. The ventral pallidum, a key member of the reward pathway, contributes to behaviors associated with reward, such as sensitization. Dopamine inputs to the ventral pallidum have not been directly characterized...
August 8, 2016: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/27476110/a-community-engaged-randomized-controlled-trial-of-an-integrative-intervention-with-hiv-positive-methamphetamine-using-men-who-have-sex-with-men
#13
Adam W Carrico, Jennifer Jain, Michael V Discepola, David Olem, Rick Andrews, William J Woods, Torsten B Neilands, Steven Shoptaw, Walter Gómez, Samantha E Dilworth, Judith T Moskowitz
BACKGROUND: Contingency management (CM) is an evidence-based intervention providing tangible rewards as positive reinforcement for abstinence from stimulants such as methamphetamine. Integrative approaches targeting affect regulation could boost the effectiveness of CM in community-based settings and optimize HIV/AIDS prevention efforts. METHODS/DESIGN: This randomized controlled trial with HIV-positive, methamphetamine-using men who have sex with men (MSM) is examining the efficacy of a 5-session, individually delivered positive affect regulation intervention - Affect Regulation Treatment to Enhance Methamphetamine Intervention Success (ARTEMIS)...
2016: BMC Public Health
https://www.readbyqxmd.com/read/27398730/increased-self-reported-impulsivity-in-methamphetamine-users-maintaining-drug-abstinence
#14
Hannah W Jones, Andy C Dean, Kimberly A Price, Edythe D London
BACKGROUND: Impulsivity has been proposed as an important factor in the initiation and maintenance of addiction. Indirect evidence suggests that some methamphetamine users report less impulsivity when they are using methamphetamine compared to when abstaining from drug use, but this hypothesis has not been directly tested. OBJECTIVES/METHODS: In this study, self-reports of impulsivity were obtained from 32 methamphetamine-dependent (DSM-IV) research participants and 41 healthy control subjects, using the Barratt Impulsiveness Scale-11...
September 2016: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/27383263/differentiation-of-ring-substituted-regioisomers-of-amphetamine-and-methamphetamine-by-supercritical-fluid-chromatography
#15
Hiroki Segawa, Yuko T Iwata, Tadashi Yamamuro, Kenji Kuwayama, Kenji Tsujikawa, Tatsuyuki Kanamori, Hiroyuki Inoue
Chromatographic differentiation of the ring-substituted regioisomers of amphetamine (AMP) and methamphetamine (MA) was performed by supercritical fluid chromatography (SFC). The behavior of the retention against the changes of column temperature and co-solvent proportion was studied. The obtained information facilitated the optimization of the each regioisomer. As a result, 2-, 3-, and 4-ring-substituted analogs of AMP and MA with methyl, methoxy, fluoro, chloro, and bromo groups were separated, generally within 6 min...
July 6, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27351193/the-relationship-between-methamphetamine-use-sexual-sensation-seeking-and-condomless-anal-intercourse-among-men-who-have-sex-with-men-in-vietnam-results-of-a-community-based-cross-sectional-study
#16
Nga Thi Thu Vu, Martin Holt, Huong Thi Thu Phan, Lan Thi La, Gioi Minh Tran, Tung Thanh Doan, Trang Nhu Nguyen Nguyen, John de Wit
This study assessed the relationship between methamphetamine use and condomless anal intercourse (CAI) among men who have sex with men (MSM) in Hanoi and Ho Chi Minh City, Vietnam. Of 622 MSM participants, 75.7% reported any CAI in the last three months, 23.2% reported engaging in sex work in the last three months, 21.1% reported group sex in the last twelve months (21.1%) and 14.3% had used methamphetamine for sex in the last three months. CAI was associated with living in Ho Chi Minh City vs. Hanoi, being versatile during anal sex, a greater degree of sexual sensation-seeking, and more strongly agreeing that withdrawal before ejaculation is effective in preventing HIV...
June 28, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27265782/the-expression-of-methiopropamine-induced-locomotor-sensitization-requires-dopamine-d2-but-not-d1-receptor-activation-in-the-rat
#17
Hyung Shin Yoon, Wen Ting Cai, Young Hun Lee, Kyung Tae Park, Yong Sup Lee, Jeong-Hoon Kim
Methiopropamine (MPA) is a structural analog to methamphetamine and is categorized as a novel psychoactive substance that needs to be controlled. However, no study has been performed to determine whether MPA actually develops an addiction-like behavior similar to those arising from other psychomotor stimulants. Thus, we attempted to determine whether MPA produces locomotor sensitization in a manner similar to amphetamine. In the first experiment, rats were pre-exposed to either saline or one of three different doses of MPA (0...
September 15, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27264310/ampa-receptor-plasticity-in-accumbens-core-contributes-to-incubation-of-methamphetamine-craving
#18
Andrew F Scheyer, Jessica A Loweth, Daniel T Christian, Jamie Uejima, Rana Rabei, Tuan Le, Hubert Dolubizno, Michael T Stefanik, Conor H Murray, Courtney Sakas, Marina E Wolf
BACKGROUND: The incubation of cue-induced drug craving in rodents provides a model of persistent vulnerability to craving and relapse in human addicts. After prolonged withdrawal, incubated cocaine craving depends on strengthening of nucleus accumbens (NAc) core synapses through incorporation of Ca(2+)-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (CP-AMPARs). Through metabotropic glutamate receptor 1 (mGluR1)-mediated synaptic depression, mGluR1 positive allosteric modulators remove CP-AMPARs from these synapses and thereby reduce cocaine craving...
November 1, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27071042/differences-in-clinical-features-of-methamphetamine-users-with-persistent-psychosis-and-patients-with-schizophrenia
#19
Liang-Jen Wang, Shih-Ku Lin, Yi-Chih Chen, Ming-Chyi Huang, Tzu-Ting Chen, Shao-Chun Ree, Chih-Ken Chen
BACKGROUND: Methamphetamine exerts neurotoxic effects and elicits psychotic symptoms. This study attempted to compare clinical differences between methamphetamine users with persistent psychosis (MAP) and patients with schizophrenia. In addition, we examined the discrimination validity by using symptom clusters to differentiate between MAP and schizophrenia. METHODS: We enrolled 53 MAP patients and 53 patients with schizophrenia. The psychopathology of participants was assessed using the Chinese version of the Diagnostic Interview for Genetic Studies and the 18-item Brief Psychiatric Rating Scale...
2016: Psychopathology
https://www.readbyqxmd.com/read/26989042/incubation-of-extinction-responding-and-cue-induced-reinstatement-but-not-context-or-drug-priming-induced-reinstatement-after-withdrawal-from-methamphetamine
#20
Sweta Adhikary, Daniele Caprioli, Marco Venniro, Paige Kallenberger, Yavin Shaham, Jennifer M Bossert
In rats trained to self-administer methamphetamine, extinction responding in the presence of drug-associated contextual and discrete cues progressively increases after withdrawal (incubation of methamphetamine craving). The conditioning factors underlying this incubation are unknown. Here, we studied incubation of methamphetamine craving under different experimental conditions to identify factors contributing to this incubation. We also determined whether the rats' response to methamphetamine priming incubates after withdrawal...
March 14, 2016: Addiction Biology
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