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Bacterial vaginosis

Nadia Kancheva Landolt, Surasith Chaithongwongwatthana, Sumanee Nilgate, Nipat Teeratakulpisarn, Sasiwimol Ubolyam, Tanakorn Apornpong, Jintanat Ananworanich, Nittaya Phanuphak
The study assessed and compared bacterial vaginosis (BV) prevalence in Thai women in reproductive age in four study groups - group 1, HIV-positive with copper intrauterine device (Cu-IUD); group 2, HIV-positive without Cu-IUD; group 3, HIV-negative with Cu-IUD; and group 4, HIV-negative without Cu-IUD. We conducted a cross-sectional study. BV prevalence was assessed by Nugent score and Amsel criteria. Descriptive statistics was used to present baseline characteristics; kwallis rank test - to compare variables between the four groups; logistic regression - to assess factors, related to BV prevalence...
March 15, 2018: AIDS Care
Pablo Romero-Morelos, Cindy Bandala, Julián Jiménez-Tenorio, Mariana Valdespino-Zavala, Miriam Rodríguez-Esquivel, Reyna Anaid Gama-Ríos, Artfy Bandera, Mónica Mendoza-Rodríguez, Keiko Taniguchi, Daniel Marrero-Rodríguez, Ricardo López-Romero, Eva Ramón-Gallegos, Mauricio Salcedo
BACKGROUND AND OBJECTIVE: Cervical cancer is an important health problem in our country. It is known that there are several risk factors for this neoplasm, and it has been suggested that cervical microbiome alterations could play a role in the development and progress of cancer. Bacterial vaginosis associated bacteria such as Atopobium vaginae and Gardnerella vaginalis has been suggested as potential risk factor for cervical lesions and cervical cancer. MATERIAL AND METHODS: DNA from 177 cervical scraping samples was studied: 104 belonged to women without cytological or colposcopic alterations and 73 samples from precursor lesions with previous human papillomavirus (HPV) infection history...
March 12, 2018: Medicina Clínica
Immaculada Moreno
The clinical impact of bacterial vaginosis (BV) in assisted reproduction has long been discussed with lack of consensus in the scientific and medical communities. While some authors, associate BV with poor pregnancy outcomes, others present data in which similar results are achieved despite the presence of BV. A previous systematic review published in 2013 by van Oostrum and cols concluded that BV did not influence pregnancy rates or other outcomes but was positively associated with preclinical pregnancy loss (van Oostrum et al...
March 14, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
Antonio Cianci, Ettore Cicinelli, Vincenzo De Leo, Franca Fruzzetti, Maria Giulia Massaro, Alessandro Bulfoni, Fabio Parazzini, Antonio Perino
We performed a prospective cohort parallel observational study on the use of Lactobacillus plantarum P 17630 in the prevention of vaginal infections. Eligible were women with a diagnosis of bacterial vaginosis (<15 days) and documented history of recurrent vaginal infections; and/or cystitis (<15 days); and/or treatment with antibiotics for bacterial respiratory tract infections during the week before the study entry. Study subjects were prescribed Lactobacillus plantarum P 17630 > 100.000...
March 12, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Sharon L Achilles, Michele N Austin, Leslie A Meyn, Felix Mhlanga, Zvavahera M Chirenje, Sharon L Hillier
BACKGROUND: Data evaluating the impact of contraceptives on the vaginal microbiome are limited and inconsistent. OBJECTIVE: We hypothesized that women initiating copper intrauterine device use would have increased bacterial vaginosis and bacterial vaginosis-associated microbes with use compared to women initiating and using hormonal contraceptive methods. STUDY DESIGN: Vaginal swabs (N=1047 from 266 participants seeking contraception) for Nugent score determination of bacterial vaginosis (BV) and quantitative polymerase chain reaction analyses for assessment of specific microbiota were collected from asymptomatic, healthy women aged 18-35 in Harare, Zimbabwe who were confirmed to be free of non-study hormones by mass spectrometry at each visit...
March 2, 2018: American Journal of Obstetrics and Gynecology
Ana María Salinas, Verónica Gabriela Osorio, Pablo Francisco Endara, Eduardo Ramiro Salazar, Gabriela Piedad Vasco, Sandra Guadalupe Vivero, Antonio Machado
Background: Bacterial vaginosis (BV) is a microbial imbalance (i.e., dysbiosis) that can produce serious medical effects in women at childbearing age. Little is known, however, about the incidence of BV or vaginal microbiota dysbiosis in pregnant teenagers in low and middle-income countries such as Ecuador. The scope of this exploratory analysis was to study the relationship between epidemiologic and microbial risk factors. Among the microbiology risk factors this study investigated five Lactobacillus species, two of them know in preview studies as microbiology risk factors for BV development ( Lactobacillus acidophilus and Lactobacillus iners ), and the last three known for being associated with a healthy vaginal tract ( Lactobacillus crispatus , Lactobacillus gasseri and Lactobacillus jensenii )...
2018: PeerJ
Elizabeth A Torrone, Charles S Morrison, Pai-Lien Chen, Cynthia Kwok, Suzanna C Francis, Richard J Hayes, Katharine J Looker, Sheena McCormack, Nuala McGrath, Janneke H H M van de Wijgert, Deborah Watson-Jones, Nicola Low, Sami L Gottlieb
BACKGROUND: Estimates of sexually transmitted infection (STI) prevalence are essential for efforts to prevent and control STIs. Few large STI prevalence studies exist, especially for low- and middle-income countries (LMICs). Our primary objective was to estimate the prevalence of chlamydia, gonorrhea, trichomoniasis, syphilis, herpes simplex virus type 2 (HSV-2), and bacterial vaginosis (BV) among women in sub-Saharan Africa by age, region, and population type. METHODS AND FINDINGS: We analyzed individual-level data from 18 HIV prevention studies (cohort studies and randomized controlled trials; conducted during 1993-2011), representing >37,000 women, that tested participants for ≥1 selected STIs or BV at baseline...
February 2018: PLoS Medicine
Suzanna C Francis, T Nondumiso Mthiyane, Kathy Baisley, S Lerato Mchunu, Jane B Ferguson, Theresa Smit, Tania Crucitti, Dickman Gareta, Siphephelo Dlamini, Tinofa Mutevedzi, Janet Seeley, Deenan Pillay, Nuala McGrath, Maryam Shahmanesh
BACKGROUND: Sexually transmitted infections (STIs) and bacterial vaginosis (BV) are associated with increased transmission of HIV, and poor reproductive and sexual health. The burden of STIs/BV among young people is unknown in many high HIV prevalence settings. We conducted an acceptability, feasibility, and prevalence study of home-based sampling for STIs/BV among young men and women aged 15-24 years old in a health and demographic surveillance site (HDSS) in rural KwaZulu-Natal, South Africa...
February 2018: PLoS Medicine
Sophia M R Lannon, Kristina M Adams Waldorf, Tina Fiedler, Raj P Kapur, Kathy Agnew, Lakshmi Rajagopal, Michael G Gravett, David N Fredricks
BACKGROUND: The majority of early preterm births are associated with intrauterine infections, which are thought to occur when microbes traffic into the uterus from the lower genital tract and seed the placenta. Bacterial vaginosis (BV) is associated with heterogeneous bacterial communities in the vagina and is linked to preterm birth. The extent to which trafficking into the uterus of normal and BV-associated vaginal bacteria occurs is unknown. The study objective was to characterize in parallel the distribution and quantities of bacteria in the vagina, uterus, and placental compartments...
February 25, 2018: Journal of Maternal-fetal & Neonatal Medicine
Nicole J Fregosi, Deslyn T G Hobson, Casey L Kinman, Jeremy T Gaskins, J Ryan Stewart, Kate V Meriwether
OBJECTIVE: The aim of the study was to describe the effect of frequency of pessary removal on the vaginal microenvironment. METHODS: We performed a secondary analysis of a multicenter randomized trial of hydroxyquinoline gel in women presenting for pessary fitting. Patients had vaginal secretions analyzed at baseline, 2 weeks, and 3 months. Patients were stratified by frequency of pessary removal at least once daily, at least once weekly, and less often than once weekly...
March 2018: Female Pelvic Medicine & Reconstructive Surgery
Carolina Sanitá Tafner Ferreira, Márcia Guimarães da Silva, Letícia Gomes de Pontes, Lucilene Delazari Dos Santos, Camila Marconi
OBJECTIVES: The aim of the study was to compare, using a proteomic approach, cervicovaginal fluid (CVF) proteins of women with bacterial vaginosis (BV) with those presenting normal microbiota. MATERIALS AND METHODS: A total of 309 reproductive-aged women were cross-sectionally enrolled. Participants were tested for vaginal candidosis, Trichomonas vaginalis, Chlamydia trachomatis, and Neisseria gonorrhoeae and excluded if positive. Vaginal microbiota was classified microscopically according to Nugent criteria in normal, intermediate, and BV...
February 23, 2018: Journal of Lower Genital Tract Disease
Thor Haahr, Jane Zacho, Merethe Bräuner, K Shathmigha, Jørgen Skov Jensen, Peter Humaidan
BACKGROUND: Despite recent efforts, the risks associated with bacterial vaginosis (BV) or abnormal vaginal microbiota in IVF patients are not well-established. OBJECTIVES: We aimed to evaluate the risks associated with BV in IVF patients using meta-analysis. SEARCH STRATEGY: Following preliminary searches in order to find relevant key words and MeSH terms, a systematic search was performed in Pubmed (Medline) September 2017. SELECTION CRITERIA: The population was infertile women attending IVF treatment...
February 22, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
Z Mike Chirenje, Nicholas Dhibi, H Hunter Handsfield, Elizabeth Gonese, Beth Tippett Barr, Lovemore Gwanzura, Ahmed S Latif, Dumisili Venessa Maseko, Ranmini S Kularatne, Mufuta Tshimanga, Peter H Kilmarx, Anna Machiha, Owen Mugurungi, Cornelis A Rietmeijer
INTRODUCTION: Symptomatic vaginal discharge is a common gynecological condition managed syndromically in most developing countries. In Zimbabwe, women presenting with symptomatic vaginal discharge are treated with empirical regimens that commonly cover both sexually transmitted infections (STI) and reproductive tract infections, typically including a combination of an intramuscular injection of kanamycin, and oral doxycycline and metronidazole regimens. This study was conducted to determine the current etiology of symptomatic vaginal discharge and assess adequacy of current syndromic management guidelines...
November 29, 2017: Sexually Transmitted Diseases
Rebecca G Nowak, Tara M Randis, Purnahamsi Desai, Xin He, Courtney K Robinson, Jessica Rath, Elbert D Glover, Adam J Ratner, Jacques Ravel, Rebecca M Brotman
Vaginolysin (VLY), a cytotoxic protein produced by Gardnerella vaginalis, may contribute to bacterial vaginosis (BV). Women with G. vaginalis, low levels of lactobacilli, history of vaginal douching, higher Nugent scores, and higher vaginal pH had increased VLY. Inflammatory markers were not highly expressed with increasing VLY. VLY's role in BV warrants further evaluation.
December 5, 2017: Sexually Transmitted Diseases
Lina Yan, Ting Luan, Quan Hua, Yun Gu, Ziyi Fu, Xia Liu, Minghui Li, Chengxin Liu, Ping Li, Xin Zeng
The female genital system infections have high-incidence among various gynecological diseases. The role of endogenous peptides in female reproductive tract secretion has been rarely investigated regarding gynecological infections. To identify gynecological infections associated endogenous peptides, a comparative peptidomic profiling of vaginal secretion from sexually mature and perimenopause women was conducted in this study using nanoflow liquid chromatography-tandem mass spectrometer. A total of 3096 peptide fragments originating from 1364 precursor proteins were identified, 102 of which were discrepantly expressed, which included 60 over-expressed peptides and 42 under-expressed peptides in the sexually mature group compared with the perimenopause group...
January 1, 2018: Journal of Biomedical Nanotechnology
Carolina M A Santos, Maria Cecília V Pires, Thiago L Leão, Anna Karolina S Silva, Lilian S Miranda, Flaviano S Martins, Aristóbolo M Silva, Jacques R Nicoli
Lactobacilli are the dominant bacteria of the vaginal tract of healthy women and they play a major role in the maintenance of mucosal homeostasis, preventing genital infections, such as bacterial vaginosis (BV) and vulvovaginal candidiasis (VVC). It is now known that one mechanism of this protection is the influence that lactobacilli can exert on host immune responses. In this context, we evaluated two Lactobacillus strains (L. plantarum 59 and L. fermentum 137) for their immunomodulatory properties in response to Gardnerella vaginalis (BV) or Candida albicans (VVC) infections in a HeLa cell infection model...
January 23, 2018: Microbiology
Gilbert Gerard Ghislain Donders, G Bellen, Kateryna Ruban, Ben Van Bulck
BACKGROUND: Recurrent vulvovaginal infections are a frequent complaint in young women in need of contraception. However, the influence of the contraceptive method on the course of the disease is not well known. AIM: To investigate the influence of the levonorgestrel-releasing intrauterine-system (LNG-IUS) on the vaginal microflora. METHODS: Short-term (3 months) and long-term (1 to 5 years) changes of vaginal microbiota were compared with pre-insertion values in 252 women presenting for LNG-IUS insertion...
January 29, 2018: Journal of Medical Microbiology
Sahar Sabour, Mohsen Arzanlou, Hamid Vaez, Giti Rahimi, Amirhossein Sahebkar, Farzad Khademi
PURPOSE: Bacterial vaginosis (BV) is a vaginal disorder which occurs either symptomatic or asymptomatic because of an imbalance between H2 O2 -producing Lactobacillus and Gardnerella vaginalis in the vagina. This systematic review and meta-analysis is the first to determine the prevalence of BV in pregnant and non-pregnant women in Iran. METHODS: We used national (SID, Irandoc, Iranmedex and Magiran) and international (PubMed, Scopus, Google Scholar and ISI web of knowledge) electronic databases to systematically search and collect available studies using related keywords (up to 1 December 2017)...
February 17, 2018: Archives of Gynecology and Obstetrics
Lisa M Starr, Taghreed Heba, Daniel Dufort
OBJECTIVE: NODAL has been implicated in timing of parturition and immune regulation. We investigated the relationship between NODAL polymorphisms, infection/inflammation, and preterm birth. STUDY DESIGN: For this secondary analysis, 613 women (189 preterm and 424 term) from the Montreal Prematurity Study were genotyped for NODAL polymorphisms and assessed for bacterial vaginosis and placental inflammation. RESULT: NODAL polymorphisms were not associated with preterm birth...
February 16, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
Khoudia Diop, Awa Diop, Anthony Levasseur, Oleg Mediannikov, Catherine Robert, Nicholas Armstrong, Carine Couderc, Florence Bretelle, Didier Raoult, Pierre-Edouard Fournier, Florence Fenollar
Microbial culturomics is a new subfield of postgenomic medicine and omics biotechnology application that has broadened our awareness on bacterial diversity of the human microbiome, including the human vaginal flora bacterial diversity. Using culturomics, a new obligate anaerobic Gram-stain-negative rod-shaped bacterium designated strain khD1 T was isolated in the vagina of a patient with bacterial vaginosis and characterized using taxonogenomics. The most abundant cellular fatty acids were C 15:0 anteiso (36%), C 16:0 (19%), and C 15:0 iso (10%)...
February 15, 2018: Omics: a Journal of Integrative Biology
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