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Bacterial vaginosis

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https://www.readbyqxmd.com/read/29135564/bacterial-vaginosis-a-practical-review
#1
Paulette Bagnall, Denise Rizzolo
Bacterial vaginosis is a common vaginal infection that causes discharge, odor, and irritation. It can predispose women to sexually transmitted infections (STIs) including HIV. Recurrent bacterial vaginosis may require prolonged treatment to return the vaginal flora to a normal predominately lactobacillidominated environment.
November 9, 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/29133803/microbial-diversity-of-genital-ulcers-of-hsv-2-seropositive-women
#2
Supriya D Mehta, Ashish K Pradhan, Stefan J Green, Ankur Naqib, Elijah Odoyo-June, Charlotte A Gaydos, Sheila Barry, Alan Landay, Robert C Bailey
We measured the microbial community structure of genital ulcers in women. Swabs from clinically detected ulcers were tested for HSV-2 and Treponema pallidum by polymerase chain reaction (PCR). HSV-2 and T. pallidum were detected by serum antibody testing. Microbial community structure was characterized by high-throughput 16 s rRNA gene amplicon sequencing. Multiple group testing and Elastic net and Lasso regressions identified taxa associated with differences in factors of interest. Among 49 ulcer specimens from 49 HSV-2 seropositive women, by PCR HSV-2 was recovered from 28 (57%) specimens and T...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29132478/treatment-for-symptomatic-bacterial-vaginosis-arandomized-controlled-trial
#3
Nabia Tariq, Ayesha Basharat, Danish Hassan Khan, Ammad Fahim, Mohammad Hisham Khan
OBJECTIVE: To compare the efficacy of multiple doses of vaginal clindamycin with a single oral dose of secnidazole for the treatment of bacterial vaginosis. STUDY DESIGN: Double-blinded randomized controlled trial. PLACE AND DURATION OF STUDY: Shifa Foundation Community Health Center, from March 2012 till February 2015. METHODOLOGY: After obtaining written informed consent, a pelvic examination was performed for the confirmation of symptoms of milky white vaginal discharge on speculum examination, positive Amine test and presence of clue cells on microscopy...
November 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29130974/atypical-squamous-cells-in-liquid-based-cervical-cytology-microbiology-inflammatory-infiltrate-and-human-papillomavirus-dna-testing
#4
Geilson Gomes de Oliveira, Renata Mirian Nunes Eleutério, Ana Katherine Silveira Gonçalves, Paulo César Giraldo, José Eleutério
OBJECTIVE: The aim of this study was to assess the correlation between atypical squamous cells (ASC) and inflammatory infiltrate and vaginal microbiota using cervical liquid-based cytological (SurePath®) and high-risk human papillomavirus (HR-HPV) tests. STUDY DESIGN: A cross-sectional study was conducted using a 6-year database from a laboratory in Fortaleza (Brazil). Files from 1,346 ASC cases were divided into subgroups and results concerning inflammation and vaginal microorganisms diagnosed by cytology were compared with HR-HPV test results...
November 8, 2017: Acta Cytologica
https://www.readbyqxmd.com/read/29125715/two-phase-1-open-label-single-dose-randomized-crossover-studies-to-assess-the-pharmacokinetics-safety-and-tolerability-of-orally-administered-granules-of-secnidazole-2-g-in-healthy-female-volunteers-under-different-administration-conditions
#5
Helen S Pentikis, Nikki Adetoro
Bacterial vaginosis (BV) is the most common vaginal infection in reproductive-age women and a significant risk factor for sexually transmitted diseases and pregnancy complications. Standard 5- to 7-day antimicrobial treatments for BV are associated with high rates of recurrence and adverse events. SYM-1219 is a novel granule formulation containing 2 g of secnidazole, developed as an oral, single-dose BV treatment. Two phase 1, open-label, single-center, randomized, crossover trials (studies 102 and 103) assessed the pharmacokinetics and safety of SYM-1219 single doses (≥7-day washout between doses) in healthy, nonpregnant women aged 18 to 65 years inclusive...
November 10, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29108022/risk-factors-for-hiv-infection-among-female-sex-workers-in-bangui-central-african-republic
#6
Jean De Dieu Longo, Marcel Mbeko Simaleko, Henri Saint-Calvaire Diemer, Gérard Grésenguet, Gilles Brücker, Laurent Belec
OBJECTIVE: The aims of the study were i) to categorize female sex workers (FSW) according to socio-anthropologic criteria in Bangui; ii) to examine the association between a selection of demographic and risk variables with the different categories of female sex work as outcome, and iii) to investigate factors associated with HIV status. METHODS: A cross-sectional questionnaire survey was conducted to describe the spectrum of commercial sex work in Bangui among 345 sexually active women...
2017: PloS One
https://www.readbyqxmd.com/read/29095928/association-of-high-risk-sexual-behaviour-with-diversity-of-the-vaginal-microbiota-and-abundance-of-lactobacillus
#7
Jocelyn M Wessels, Julie Lajoie, Danielle Vitali, Kenneth Omollo, Joshua Kimani, Julius Oyugi, Juliana Cheruiyot, Makubo Kimani, John N Mungai, Maureen Akolo, Jennifer C Stearns, Michael G Surette, Keith R Fowke, Charu Kaushic
OBJECTIVE: To compare the vaginal microbiota of women engaged in high-risk sexual behaviour (sex work) with women who are not engaged in high-risk sexual behaviour. Diverse vaginal microbiota, low in Lactobacillus species, like those in bacterial vaginosis (BV), are associated with increased prevalence of sexually transmitted infections (STIs) and human immunodeficiency virus (HIV) acquisition. Although high-risk sexual behaviour increases risk for STIs, the vaginal microbiota of sex workers is understudied...
2017: PloS One
https://www.readbyqxmd.com/read/29066031/self-reported-bacterial-vaginosis-and-risk-of-ultrasound-diagnosed-incident-uterine-fibroid-cases-in-a-prospective-cohort-study-of-young-african-american-women
#8
Kristen R Moore, Donna D Baird
No abstract text is available yet for this article.
October 13, 2017: Annals of Epidemiology
https://www.readbyqxmd.com/read/29065710/effect-of-a-yoghurt-drink-containing-lactobacillus-strains-on-bacterial-vaginosis-in-women-a-double-blind-randomised-controlled-clinical-pilot-trial
#9
C Laue, E Papazova, A Liesegang, A Pannenbeckers, P Arendarski, B Linnerth, K J Domig, W Kneifel, L Petricevic, J Schrezenmeir
Bacterial vaginosis (BV) is characterised by a depletion of lactobacilli in favour of an overgrowth of anaerobic bacteria. It is associated with increased risk for urogenital infections and abortion. In this study we assessed the effect of a yoghurt drink containing Lactobacillus strains on BV. The strains had been isolated from healthy pregnant women and selected for acidification capacity, production of H2O2, glycogen utilisation, bile salt tolerance and inhibition of pathogens. Using Amsel criteria BV was diagnosed in 36 women aged ≥18 years with stable menstrual cycle or menopause...
October 25, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/29059077/the-microbiome-and-hiv-prevention-strategies-in-women
#10
Salim S Abdool Karim, Jo-Ann S Passmore, Cheryl Baxter
PURPOSE OF REVIEW: HIV prevention approaches that women can use and control are a priority. Results from topical and oral preexposure prophylaxis (PrEP) HIV prevention trials have produced inconsistent results in women. One of the main behavioural factors impacting effectiveness of PrEP has been suboptimal adherence. In this review, we examine biological factors that modulate topical PrEP efficacy, with particular focus on the vaginal microbiome. RECENT FINDINGS: Genital inflammation is an independent risk factor for HIV acquisition in women...
October 20, 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/29057083/low-level-genital-hiv-shedding-in-thai-hiv-infected-women-with-suppressed-plasma-viral-load-after-menopause-a-longitudinal-study
#11
EDITORIAL
Nadia Kancheva Landolt, Tanya Do, Naruporn Kasipong, Rosalin Kriengsinyot, Sasiwimol Ubolyam, Apicha Mahanontharit, Tippawan Pankam, Tanakorn Apornpong, Anchalee Avihingsanon, Jintanat Ananworanich, Nittaya Phanuphak, Surasith Chaithongwongwatthana
OBJECTIVES: First, to evaluate the longitudinal changes of HIV RNA in genital secretions in HIV-positive women with plasma HIV RNA <50 copies/mL before and after the onset of menopause. Second, to assess inflammatory markers and prevalence of comorbidities after the onset of menopause. METHODS: This was a prospective observational study with two time points. HIV RNA in genital secretions (GVL) was measured in 15 HIV-positive menopausal women (second time point)...
October 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/29043893/considerations-on-risk-of-bacterial-vaginosis-trichomonas-vaginalis-and-candida-albicans-infection-among-new-users-of-combined-hormonal-contraception-vs-lng-ius
#12
Ahmed M Abbas, Asmaa S Shaltout
No abstract text is available yet for this article.
October 18, 2017: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/29043070/bacterial%C3%A2-vaginosis
#13
REVIEW
Phillip Hay
Bacterial vaginosis is the most prevalent cause of abnormal vaginal discharge in women of childbearing age. It can have a major impact on quality of life and psychological wellbeing if frequently recurrent and strongly symptomatic. The use of molecular techniques to study the vaginal microbiome is increasing our understanding of the dynamic changes in flora that occur in health and disease. It might soon be possible to separate Gardnerella into different pathogenic and non-pathogenic species. Many groups are studying compounds that can disrupt the biofilm which is dominated by Gardnerella and Atopobium vaginae...
2017: F1000Research
https://www.readbyqxmd.com/read/29038188/probiotics-administered-intravaginally-as-a-complementary-therapy-combined-with-antibiotics-for-the-treatment-of-bacterial-vaginosis-a-systematic-review-protocol
#14
Liyan Ma, Jianrong Su, Yanli Su, Wei Sun, Zhaoying Zeng
INTRODUCTION: Bacterial vaginosis (BV) is a highly prevalent vaginal polymicrobial disorder commonly encountered in women of childbearing age. Therapy with only recommended antibiotics results in low cure rates and unacceptably high recurrence rates. The use of probiotics as a complementary approach for use with antibiotics for the treatment of BV remains unclear. This review aims to assess the efficacy of lactobacilli administered intravaginally in conjunction with antibiotics for the treatment of BV...
October 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29038128/microbial-composition-predicts-genital-tract-inflammation-and-persistent-bacterial-vaginosis-in-adolescent-south-african-women
#15
Katie Lennard, Smritee Dabee, Shaun L Barnabas, Enock Havyarimana, Anna Blakney, Shameem Z Jaumdally, Gerrit Botha, Nonhlanhla N Mkhize, Linda-Gail Bekker, David A Lewis, Glenda Gray, Nicola Mulder, Jo-Ann S Passmore, Heather B Jaspan
Young African females are at increased risk of HIV acquisition, and genital inflammation or the vaginal microbiome may contribute to this risk. We studied these factors in 168 HIV negative South African adolescent women aged 16-22 years. Unsupervised clustering of 16S rRNA gene sequences revealed three clusters (subtypes), one of which was strongly associated with genital inflammation. In a multivariate model, microbiome compositional subtype and hormonal contraception were significantly associated with genital inflammation...
October 16, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29025419/strong-associations-between-national-prevalence-of-various-stis-suggests-sexual-network-connectivity-is-a-common-underpinning-risk-factor
#16
Chris Kenyon
BACKGROUND: If national peak Human Immunodeficiency Virus (HIV) prevalence is positively associated with the prevalence of other sexually transmitted infections (STIs) from before or early on in the HIV epidemics this would suggest common underlying drivers. METHODS: Pearson's correlations were calculated between the prevalence of seven STIs at a country-level: chlamydia, gonorrhoea, trichomoniasis, syphilis, bacterial vaginosis, herpes simplex virus-2 (HSV-2) and HIV...
October 12, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28994506/inflammatory-cells-in-liquid-based-cytology-smears-classified-as-bacterial-vaginosis
#17
José Eleutério, Renata Mírian Nunes Eleutério, Leonardo Arruda Martins, Paulo César Giraldo, Ana Katherine Silveira Gonçalves
BACKGROUND: Bacterial vaginosis (BV) remains an enigmatic question. The term "osis" instead of "itis" is used because commonly, there are no inflammatory process associated with BV. However, leukocytes are often observed in it. METHODS: In a transversal study, we evaluated 1178 cases with diagnosis of BV by liquid-based cytology (more than 20% of clue cells), attended in general gynecologic private clinic. Depending of the presence of more than five leukocytes on average per field in immersion objective (1000×), the cases were divided in two groups: few or no leukocytes (< 5 leukocytes per field) (BV) and with leukocytes (≥ 5 leukocytes per field) (BV-L)...
October 10, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28994162/effect-of-probiotics-on-perinatal-outcome-in-patients-at-high-risk-of-preterm-birth
#18
Nami Kirihara, Masato Kamitomo, Tatsunori Tabira, Takashi Hashimoto, Hiroko Taniguchi, Takatsugu Maeda
AIM: Recent reports have shown lower levels of Clostridium and higher levels of Lactobacillales in the intestinal microbiota in preterm birth patients compared to term birth patients. However, the influence of probiotics on perinatal status has not been elucidated. The aim of our study was to evaluate the effects of probiotics on perinatal outcomes. METHODS: We retrospectively evaluated the effects of oral probiotics on perinatal outcome in patients at high risk of preterm birth...
October 10, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28983665/the-effect-of-prebiotic-vaginal-gel-with-adjuvant-oral-metronidazole-tablets-on-treatment-and-recurrence-of-bacterial-vaginosis-a-triple-blind-randomized-controlled-study
#19
Sevil Hakimi, Faranak Farhan, Azizeh Farshbaf-Khalili, Parvin Dehghan, Yousef Javadzadeh, Shamsi Abbasalizadeh, Bagher Khalvati
PURPOSE: Bacterial vaginosis is a change in the normal vaginal bacterial flora that leads to loss of hydrogen peroxide producing lactobacilli and overgrowth of predominantly anaerobic bacteria. The present study was conducted to compare the effects of prebiotic vaginal gel with oral metronidazole tablet and metronidazole tablet alone on treatment and recurrence of bacterial vaginosis. METHODS: The present triple-blind randomized clinical trial was conducted in Sadatmandi Hospital in Robat-Karim town, where 100 patients were randomly divided into intervention (receiving a 5 mg prebiotic vaginal gel applicator plus three 250 mg metronidazole tablets per day for 7 days) and control (receiving a 5 mg placebo vaginal gel applicator and three 250 mg metronidazole tablets per day for 7 days) groups...
October 5, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28969122/comparative-study-on-the-vaginal-flora-and-incidence-of-asymptomatic-vaginosis-among-healthy-women-and-in-women-with-infertility-problems-of-reproductive-age
#20
Geethavani Babu, Balamuru Ganvelu Singaravelu, R Srikumar, Sreenivasalu V Reddy, Afraa Kokan
INTRODUCTION: The normal vaginal flora is highly complex, dominated by lactobacilli of doderlein that plays a vital role in maintaining the women's health and inhibits other pathogenic microorganisms. Fluctuation in local environment or exposure to any exogenous and endogenous sources changes the vaginal flora over a period of time. Disruption of the vaginal ecosystem changes the microflora of the healthy vagina, altering the pH and predisposing to lower reproductive tract infections...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
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