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https://www.readbyqxmd.com/read/28732342/scope-mtl-a-non-invasive-tool-for-identifying-and-lateralizing-mesial-temporal-lobe-seizures-prior-to-scalp-eeg-ictal-onset
#1
Alice D Lam, Douglas Maus, Sahar F Zafar, Andrew J Cole, Sydney S Cash
OBJECTIVE: In mesial temporal lobe (mTL) epilepsy, seizure onset can precede the appearance of a scalp EEG ictal pattern by many seconds. The ability to identify this early, occult mTL seizure activity could improve lateralization and localization of mTL seizures on scalp EEG. METHODS: Using scalp EEG spectral features and machine learning approaches on a dataset of combined scalp EEG and foramen ovale electrode recordings in patients with mTL epilepsy, we developed an algorithm, SCOPE-mTL, to detect and lateralize early, occult mTL seizure activity, prior to the appearance of a scalp EEG ictal pattern...
July 1, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28732323/evaluation-of-an-online-training-for-improving-self-reported-evidence-based-decision-making-skills-in-cancer-control-among-public-health-professionals
#2
A B Morshed, P Ballew, M B Elliott, D Haire-Joshu, M W Kreuter, R C Brownson
OBJECTIVES: The purpose of this evaluation was to assess the effect of the online evidence-based cancer control (EBCC) training on improving the self-reported evidence-based decision-making (EBDM) skills in cancer control among Nebraska public health professionals. STUDY DESIGN: Cross-sectional group comparison. METHODS: Previously developed EBDM measures were administered via online surveys to 201 public health professionals at baseline (comparison group) and 123 professionals who took part in the training...
July 18, 2017: Public Health
https://www.readbyqxmd.com/read/28732265/chronic-work-stress-and-decreased-vagal-tone-impairs-decision-making-and-reaction-time-in-jockeys
#3
Kathleen Landolt, Paul Maruff, Ben Horan, Michael Kingsley, Glynda Kinsella, Paul D O'Halloran, Matthew W Hale, Bradley J Wright
The inverse relationship between acute stress and decision-making is well documented, but few studies have investigated the impact of chronic stress. Jockeys work exhaustive schedules and have extremely dangerous occupations, with safe performance requiring quick reaction time and accurate decision-making. We used the effort reward imbalance (ERI) occupational stress model to assess the relationship of work stress with indices of stress physiology and decision-making and reaction time. Jockeys (N=32) completed computerised cognitive tasks (Cogstate) on two occasions; September and November (naturally occurring lower and higher stress periods), either side of an acute stress test...
July 14, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28732187/do-genetic-markers-of-inflammation-modify-the-relationship-between-periodontitis-and-nonalcoholic-fatty-liver-disease-findings-from-the-ship-study
#4
A A Akinkugbe, C L Avery, A S Barritt, S R Cole, M Lerch, J Mayerle, S Offenbacher, A Petersmann, M Nauck, H Völzke, G D Slade, G Heiss, T Kocher, B Holtfreter
An association between periodontitis and nonalcoholic fatty liver disease (NAFLD) has been reported by experimental animal and epidemiologic studies. This study investigated whether circulating levels of serum C-reactive protein (CRP) and a weighted genetic CRP score representing markers of inflammatory burden modify the association between periodontitis and NAFLD. Data came from 2,481 participants of the Study of Health in Pomerania who attended baseline examination that occurred between 1997 and 2001. Periodontitis was defined as the percentage of sites (0%, <30%, ≥30%) with probing pocket depth (PD) ≥4 mm, and NAFLD status was determined using liver ultrasound assessment...
July 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28732181/irf6-and-spry4-signaling-interact-in-periderm-development
#5
Y A Kousa, R Roushangar, N Patel, A Walter, P Marangoni, R Krumlauf, O D Klein, B C Schutte
Rare mutations in IRF6 and GRHL3 cause Van der Woude syndrome, an autosomal dominant orofacial clefting disorder. Common variants in IRF6 and GRHL3 also contribute risk for isolated orofacial clefting. Similarly, variants within genes that encode receptor tyrosine kinase (RTK) signaling components, including members of the FGF pathway, EPHA3 and SPRY2, also contribute risk for isolated orofacial clefting. In the mouse, loss of Irf6 or perturbation of Fgf signaling leads to abnormal oral epithelial adhesions and cleft palate...
July 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28732083/apol1-risk-alleles-among-individuals-with-ckd-in-northern-tanzania-a-pilot-study
#6
John W Stanifer, Francis Karia, Venance Maro, Kajiru Kilonzo, Xuejun Qin, Uptal D Patel, Elizabeth R Hauser
INTRODUCTION: In sub-Saharan Africa, approximately 100 million people have CKD, yet genetic risk factors are not well-understood. Despite the potential importance of understanding APOL1 risk allele status among individuals with CKD, little genetic research has been conducted. Therefore, we conducted a pilot study evaluating the feasibility of and willingness to participate in genetic research on kidney disease, and we estimated APOL1 risk allele frequencies among individuals with CKD...
2017: PloS One
https://www.readbyqxmd.com/read/28732065/direct-targets-of-pstat5-signalling-in-erythropoiesis
#7
Kevin R Gillinder, Hugh Tuckey, Charles C Bell, Graham W Magor, Stephen Huang, Melissa D Ilsley, Andrew C Perkins
Erythropoietin (EPO) acts through the dimeric erythropoietin receptor to stimulate proliferation, survival, differentiation and enucleation of erythroid progenitor cells. We undertook two complimentary approaches to find EPO-dependent pSTAT5 target genes in murine erythroid cells: RNA-seq of newly transcribed (4sU-labelled) RNA, and ChIP-seq for pSTAT5 30 minutes after EPO stimulation. We found 302 pSTAT5-occupied sites: ~15% of these reside in promoters while the rest reside within intronic enhancers or intergenic regions, some >100kb from the nearest TSS...
2017: PloS One
https://www.readbyqxmd.com/read/28732062/a-drosophila-model-for-toxicogenomics-genetic-variation-in-susceptibility-to-heavy-metal-exposure
#8
Shanshan Zhou, Sarah E Luoma, Genevieve E St Armour, Esha Thakkar, Trudy F C Mackay, Robert R H Anholt
The genetic factors that give rise to variation in susceptibility to environmental toxins remain largely unexplored. Studies on genetic variation in susceptibility to environmental toxins are challenging in human populations, due to the variety of clinical symptoms and difficulty in determining which symptoms causally result from toxic exposure; uncontrolled environments, often with exposure to multiple toxicants; and difficulty in relating phenotypic effect size to toxic dose, especially when symptoms become manifest with a substantial time lag...
July 21, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28732035/vaccine-induced-immune-responses-against-both-gag-and-env-improve-control-of-simian-immunodeficiency-virus-replication-in-rectally-challenged-rhesus-macaques
#9
Mauricio A Martins, Young C Shin, Lucas Gonzalez-Nieto, Aline Domingues, Martin J Gutman, Helen S Maxwell, Iris Castro, Diogo M Magnani, Michael Ricciardi, Nuria Pedreño-Lopez, Varian Bailey, Dillon Betancourt, John D Altman, Matthias Pauthner, Dennis R Burton, Benjamin von Bredow, David T Evans, Maoli Yuan, Christopher L Parks, Keisuke Ejima, David B Allison, Eva Rakasz, Glen N Barber, Saverio Capuano, Jeffrey D Lifson, Ronald C Desrosiers, David I Watkins
The ability to control lentivirus replication may be determined, in part, by the extent to which individual viral proteins are targeted by the immune system. Consequently, defining the antigens that elicit the most protective immune responses may facilitate the design of effective HIV-1 vaccines. Here we vaccinated four groups of rhesus macaques with a heterologous vector prime/boost/boost/boost (PBBB) regimen expressing the following simian immunodeficiency virus (SIV) genes: env, gag, vif, rev, tat, and nef (Group 1); env, vif, rev, tat, and nef (Group 2); gag, vif, rev, tat, and nef (Group 3); or vif, rev, tat, and nef (Group 4)...
July 21, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28731934/long-term-evaluation-of-specular-microscopic-changes-following-nd-yag-iridotomy-in-chronic-primary-angle-closure-glaucoma-eyes
#10
Ramanjit Sihota, Esha Agarwal, Mathew James, Meena Verma, Lalit Kumar, Tanuj Dada, Viney Gupta, Kulwant Singh Kapoor
AIM: The aim of this study was to evaluate specular microscopy of chronic primary angle-closure glaucoma (CPACG) eyes at least 1 year after Nd:YAG iridotomy, and compare them with CPACG eyes without an iridotomy and age-matched, normal eyes. PATIENTS AND METHOD: Consecutive patients of CPACG at the Glaucoma service were screened. All patients underwent slit-lamp biomicroscopy, +90 D examination, and applanation tonometry. A total of 100 eyes of 100 consecutive patients of CPACG with an Nd:YAG iridotomy performed ≥1 year before, who met all inclusion/exclusion criteria, 60 consecutive CPACG eyes without an iridotomy, and 60 age and refraction-matched control eyes were enrolled...
July 20, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28731929/impact-of-aortic-rather-than-brachial-pulsatile-haemodynamics-on-variations-in-end-organ-measures-across-the-full-adult-blood-pressure-range
#11
Bryan Hodson, Gavin R Norton, Imraan Ballim, Carlos D Libhaber, Pinhas Sareli, Angela J Woodiwiss
AIMS: To determine the extent to which the adverse effects of blood pressure (BP) are mediated by pulsatile haemodynamic changes across the normotensive as compared with the hypertensive adult brachial BP range, and whether aortic rather than brachial pulsatile changes best index these effects. METHODS: In 1307 community participants, the contribution of pulsatile haemodynamics (applanation tonometry and SphygmoCor software) to variations in left ventricular mass index (LVMI) (echocardiography) (n = 920), carotid intima-media thickness (IMT) (n = 712) and estimated glomerular filtration rate (eGFR) (n = 1164) were assessed...
July 20, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28731906/c1-inhibitor-treatment-decreases-renal-injury-in-an-established-brain-dead-rat-model
#12
Felix Poppelaars, Neeltina M Jager, Juha Kotimaa, Henri G D Leuvenink, Mohamed R Daha, Cees van Kooten, Marc A Seelen, Jeffrey Damman
BACKGROUND: Kidneys derived from brain-dead (BD) donors have lower graft survival rates compared to kidneys from living donors. Complement activation plays an important role in brain death. The aim of our study was therefore to investigate the effect of C1-inhibitor (C1-INH) on BD-induced renal injury. METHODS: Brain death was induced in rats by inflating a subdurally placed balloon catheter. Thirty minutes after BD, rats were treated with saline, low-dose or high-dose C1-INH...
July 21, 2017: Transplantation
https://www.readbyqxmd.com/read/28731883/the-effects-on-children-s-anxiety-and-quality-of-life-of-a-psychoeducational-program-for-families-living-with-parental-cancer-and-their-network-a-randomized-controlled-trial-study
#13
May Aasebø Hauken, Mariana Pereira, Mette Senneseth
BACKGROUND: Families living with parental cancer report lack of social support. The Cancer PEPSONE Program (CPP) was developed to bridge the gap between the families and their network. OBJECTIVE: The aims of this study were to study the effect of the CPP on children's anxiety and quality of life (QOL) and examine the association between the CPP's effect on their well parents' received social support, QOL, and psychological distress and the children's anxiety and QOL...
July 20, 2017: Cancer Nursing
https://www.readbyqxmd.com/read/28731880/refractive-surgery-malpractice-litigation-outcomes
#14
Benjamin L Custer, Steven R Ballard, Robert B Carroll, Scott D Barnes, Grant A Justin
PURPOSE: To review data on malpractice claims related to refractive surgery to identify common allegations and injuries and financial outcomes. METHODS: The WestlawNext database was reviewed for all malpractice lawsuits/settlements related to refractive eye surgery. Data evaluated included patient demographics, type of operation performed, plaintiff allegation, nature of injury, and litigation outcomes. RESULTS: A total of 167 cases met the inclusion criteria, of which 108 cases (64...
July 19, 2017: Cornea
https://www.readbyqxmd.com/read/28731878/correlation-of-corneal-biomechanical-stiffness-with-refractive-error-and-ocular-biometry-in-a-pediatric-population
#15
Jyoti Matalia, Mathew Francis, Pooja Gogri, Pratibha Panmand, Himanshu Matalia, Abhijit Sinha Roy
PURPOSE: To assess the correlation between corneal biomechanical stiffness and refractive error (RE) in the pediatric population. METHODS: A total of 733 pediatric eyes were included in the study retrospectively. All eyes underwent corneal tomography (Pentacam), RE assessment, and air-puff deformation (Corvis-ST). Waveform analyses of deformation provided corneal stiffness (CS) and extraocular tissue stiffness (EOS). Eyes were subgrouped into emmetropia [manifest refraction spherical equivalent (MRSE) ∼ 0 D], hyperopia (MRSE > 0 D), myopia I (MRSE between 0 D and -3 D), myopia II (MRSE between -3 D and -6 D), and myopia III (MRSE greater than -6 D) for multivariate analyses...
July 19, 2017: Cornea
https://www.readbyqxmd.com/read/28731819/the-close-up-imager-onboard-the-esa-exomars-rover-objectives-description-operations-and-science-validation-activities
#16
Jean-Luc Josset, Frances Westall, Beda A Hofmann, John Spray, Charles Cockell, Stephan Kempe, Andrew D Griffiths, Maria Cristina De Sanctis, Luigi Colangeli, Detlef Koschny, Karl Föllmi, Eric Verrecchia, Larryn Diamond, Marie Josset, Emmanuelle J Javaux, Francesca Esposito, Matthew Gunn, Audrey L Souchon-Leitner, Tomaso R R Bontognali, Oleg Korablev, Suren Erkman, Gerhard Paar, Stephan Ulamec, Frédéric Foucher, Philippe Martin, Antoine Verhaeghe, Mitko Tanevski, Jorge L Vago
The Close-Up Imager (CLUPI) onboard the ESA ExoMars Rover is a powerful high-resolution color camera specifically designed for close-up observations. Its accommodation on the movable drill allows multiple positioning. The science objectives of the instrument are geological characterization of rocks in terms of texture, structure, and color and the search for potential morphological biosignatures. We present the CLUPI science objectives, performance, and technical description, followed by a description of the instrument's planned operations strategy during the mission on Mars...
June 2017: Astrobiology
https://www.readbyqxmd.com/read/28731789/age-and-cancer-treatment-are-related-to-receiving-treatment-summaries-and-survivorship-care-plans-in-female-young-adult-cancer-survivors
#17
Ksenya Shliakhtsitsava, Sally A D Romero, Brian W Whitcomb, Jessica R Gorman, Samantha Roberts, H Irene Su
The study determined factors associated with patient-reported receipt of survivorship care plans and/or treatment summaries (SCP/TS). Two hundred forty female young adult cancer survivors ages 18-44 completed a web-based survey that included self-report on receiving SCP/TS. Mean age was 32.8 (standard deviation 5.8) years; 20% were diagnosed with cancer at age <21. Only 47% reported receipt of SCP/TS. Age <21 at diagnosis (odds ratio [OR] 2.0, 95% confidence interval [CI] 1.0-3.9), chemotherapy (OR 2...
July 21, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28731762/measurement-of-neutral-current-k-production-by-neutrinos-using-minerva
#18
C M Marshall, L Aliaga, O Altinok, L Bellantoni, A Bercellie, M Betancourt, A Bodek, A Bravar, T Cai, M F Carneiro, H da Motta, S A Dytman, G A Díaz, M Dunkman, B Eberly, E Endress, J Felix, L Fields, R Fine, A M Gago, R Galindo, H Gallagher, A Ghosh, T Golan, R Gran, D A Harris, A Higuera, K Hurtado, J Kleykamp, M Kordosky, T Le, E Maher, S Manly, W A Mann, D A Martinez Caicedo, K S McFarland, C L McGivern, A M McGowan, B Messerly, J Miller, A Mislivec, J G Morfín, J Mousseau, D Naples, J K Nelson, A Norrick, Nuruzzaman, V Paolone, C E Patrick, G N Perdue, M A Ramírez, R D Ransome, H Ray, L Ren, D Rimal, P A Rodrigues, D Ruterbories, D W Schmitz, C J Solano Salinas, M Sultana, S Sánchez Falero, E Valencia, T Walton, J Wolcott, M Wospakrik, B Yaeggy, D Zhang
Neutral-current production of K^{+} by atmospheric neutrinos is a background in searches for the proton decay p→K^{+}ν[over ¯]. Reactions such as νp→νK^{+}Λ are indistinguishable from proton decays when the decay products of the Λ are below detection threshold. Events with K^{+} are identified in MINERvA by reconstructing the timing signature of a K^{+} decay at rest. A sample of 201 neutrino-induced neutral-current K^{+} events is used to measure differential cross sections with respect to the K^{+} kinetic energy, and the non-K^{+} hadronic visible energy...
July 7, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28731757/phase-locking-the-spin-precession-in-a-storage-ring
#19
N Hempelmann, V Hejny, J Pretz, E Stephenson, W Augustyniak, Z Bagdasarian, M Bai, L Barion, M Berz, S Chekmenev, G Ciullo, S Dymov, F-J Etzkorn, D Eversmann, M Gaisser, R Gebel, K Grigoryev, D Grzonka, G Guidoboni, T Hanraths, D Heberling, J Hetzel, F Hinder, A Kacharava, V Kamerdzhiev, I Keshelashvili, I Koop, A Kulikov, A Lehrach, P Lenisa, N Lomidze, B Lorentz, P Maanen, G Macharashvili, A Magiera, D Mchedlishvili, S Mey, F Müller, A Nass, N N Nikolaev, A Pesce, D Prasuhn, F Rathmann, M Rosenthal, A Saleev, V Schmidt, Y Semertzidis, V Shmakova, A Silenko, J Slim, H Soltner, A Stahl, R Stassen, H Stockhorst, H Ströher, M Tabidze, G Tagliente, R Talman, P Thörngren Engblom, F Trinkel, Yu Uzikov, Yu Valdau, E Valetov, A Vassiliev, C Weidemann, A Wrońska, P Wüstner, P Zuprański, M Żurek
This Letter reports the successful use of feedback from a spin polarization measurement to the revolution frequency of a 0.97  GeV/c bunched and polarized deuteron beam in the Cooler Synchrotron (COSY) storage ring in order to control both the precession rate (≈121  kHz) and the phase of the horizontal polarization component. Real time synchronization with a radio frequency (rf) solenoid made possible the rotation of the polarization out of the horizontal plane, yielding a demonstration of the feedback method to manipulate the polarization...
July 7, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28731753/new-measurements-of-the-beam-normal-spin-asymmetries-at-large-backward-angles-with-hydrogen-and-deuterium-targets
#20
D Balaguer Ríos, K Aulenbacher, S Baunack, J Diefenbach, B Gläser, D von Harrach, Y Imai, E-M Kabuß, R Kothe, J H Lee, H Merkel, M C Mora Espí, U Müller, E Schilling, C Weinrich, L Capozza, F E Maas, J Arvieux, M A El-Yakoubi, R Frascaria, R Kunne, M Morlet, S Ong, J van de Wiele, S Kowalski, Y Prok
New measurements of the beam normal single spin asymmetry in the electron elastic and quasielastic scattering on the proton and deuteron, respectively, at large backward angles and at ⟨Q^{2}⟩=0.22  (GeV/c)^{2} and ⟨Q^{2}⟩=0.35  ( GeV/c)^{2} are reported. The experimentally observed asymmetries are compared with the theoretical calculation of Pasquini and Vanderhaeghen [Phys. Rev. C 70, 045206 (2004).PRVCAN0556-281310.1103/PhysRevC.70.045206]. The agreement of the measurements with the theoretical calculations shows a dominance of the inelastic intermediate excited states of the nucleon, πN and the Δ resonance...
July 7, 2017: Physical Review Letters
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