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https://www.readbyqxmd.com/read/29656614/6-minute-walk-test-predicts-prolonged-hospitalization-in-patients-undergoing-transcatheter-mitral-valve-repair-by-mitraclip
#1
Mike Saji, Marc R Katz, Gorav Ailawadi, Timothy S Welch, Dale E Fowler, Jamie L W Kennedy, James D Bergin, Ivandito Kuntjoro, John M Dent, Michael Ragosta, D Scott Lim
BACKGROUND: The 6-minute walk test (6MWT) is a simple functional test that can predict exercise capacity and is widely employed to assess treatment outcomes. Although mortality with transcatheter mitral valve repair (TMVr) using the MitraClip (Abbott Vascular, Menlo Park, CA) is significantly less than for open mitral valve surgery in high-risk patients, identifying which patient will benefit the most from TMVr remains a concern. There are limited prognostic metrics guiding patient selection and, no studies have reported relationship between prolonged hospitalization and 6MWT...
April 15, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29656582/hyperactive-cyclic-motor-activity-in-the-distal-colon-after-colonic-surgery-as-defined-by-high-resolution-colonic-manometry
#2
R Vather, G O'Grady, A Y Lin, P Du, C I Wells, D Rowbotham, J Arkwright, L K Cheng, P G Dinning, I P Bissett
BACKGROUND: Recovery after colonic surgery is invariably delayed by disturbed gut motility. It is commonly assumed that colonic motility becomes quiescent after surgery, but this hypothesis has not been evaluated rigorously. This study quantified colonic motility through the early postoperative period using high-resolution colonic manometry. METHODS: Fibre-optic colonic manometry was performed continuously before, during and after surgery in the left colon and rectum of patients undergoing right hemicolectomy, and in healthy controls...
April 14, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29656574/nmredata-a-standard-to-report-the-nmr-assignment-and-parameters-of-organic-compounds
#3
Marion Pupier, Jean-Marc Nuzillard, Julien Wist, Nils E Schlörer, Stefan Kuhn, Mate Erdelyi, Christoph Steinbeck, Antony J Williams, Craig Butts, Tim D W Claridge, Bozhana Mikhova, Wolfgang Robien, Hesam Dashti, Hamid R Eghbalnia, Christophe Farès, Christian Adam, Kessler Pavel, Fabrice Moriaud, Mikhail Elyashberg, Dimitris Argyropoulos, Manuel Pérez, Patrick Giraudeau, Roberto R Gil, Paul Trevorrow, Damien Jeannerat
Even though NMR has found countless applications in the field of small molecule characterization, there is no standard file format available for the NMR data relevant to structure characterization of small molecules. A new format is therefore introduced to associate the NMR parameters extracted from 1D and 2D spectra of organic compounds to the proposed chemical structure. These NMR parameters, which we shall call NMReDATA (for nuclear magnetic resonance extracted data), include chemical shift values, signal integrals, intensities, multiplicities, scalar coupling constants, lists of 2D correlations, relaxation times and diffusion rates...
April 14, 2018: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/29656514/microbial-diversity-and-biomarker-analysis-of-modern-freshwater-microbialites-from-laguna-bacalar-mexico
#4
D B Johnson, P A Beddows, T M Flynn, M R Osburn
Laguna Bacalar is a sulfate-rich freshwater lake on the Yucatan Peninsula that hosts large microbialites. High sulfate concentrations distinguish Laguna Bacalar from other freshwater microbialite sites such as Pavilion Lake and Alchichica, Mexico, as well as from other aqueous features on the Yucatan Peninsula. While cyanobacterial populations have been described here previously, this study offers a more complete characterization of the microbial populations and corresponding biogeochemical cycling using a three-pronged geobiological approach of microscopy, high-throughput DNA sequencing, and lipid biomarker analyses...
April 15, 2018: Geobiology
https://www.readbyqxmd.com/read/29656500/mitochondria-glycogen-and-lipid-droplets-in-skeletal-muscle-during-testosterone-treatment-and-strength-training-a-randomized-double-blinded-placebo-controlled-trial
#5
R C Jensen, L L Christensen, J Nielsen, H D Schrøder, T Kvorning, K Gejl, K Højlund, D Glintborg, M Andersen
Low testosterone levels in aging men are associated with insulin resistance. Mitochondrial dysfunction, changes in glycogen metabolism, and lipid accumulation are linked to insulin resistance in skeletal muscle. In this randomized, double-blinded, placebo-controlled study, we investigated the effects of six-month testosterone replacement therapy (TRT) and strength training (ST) on mitochondrial, glycogen, and lipid droplet (LD) content in skeletal muscle of aging men with subnormal bioavailable testosterone (BioT) levels...
April 15, 2018: Andrology
https://www.readbyqxmd.com/read/29656415/focusing-on-cancer-patients-intentions-to-use-psycho-oncological-support-a-longitudinal-mixed-methods-study
#6
T Tondorf, A Grossert, S I Rothschild, M T Koller, C Rochlitz, A Kiss, R Schaefert, G Meinlschmidt, S Hunziker, D Zwahlen
OBJECTIVE: Distress screening programs aim to ensure appropriate psycho-oncological support for cancer patients, but many eligible patients do not use these services. To improve distress management, we need to better understand patients' supportive care needs. In this paper, we report the first key finding from a longitudinal study that focused on patients' intentions to use psycho-oncological support, and its association with distress and uptake of the psycho-oncology service. METHODS: We conducted a prospective, observational study in an Oncology Outpatient Clinic and assessed distress, intention to use psycho-oncological support, and uptake of the psycho-oncology service using the Distress Thermometer (DT), a semi-structured interview, and hospital records...
April 15, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29656398/impact-of-prolonged-dialysis-prior-to-renal-transplantation
#7
David D Aufhauser, Allison W Peng, Douglas R Murken, Seth J Concors, Peter L Abt, Deirdre Sawinski, Roy D Bloom, Peter P Reese, Matthew H Levine
INTRODUCTION: The new Kidney Allocation System (KAS) prioritizes patients based on date of dialysis initiation or wait-listing, whichever is earlier. We hypothesized that this change would increase transplant rates for patients with prolonged pre-transplant dialysis times (DT) and aimed to assess the impact of prolonged DT on post-transplant outcomes. METHODS: We used United Network for Organ Sharing registry data to assess outcomes for patients added to the renal transplant waitlist from Jan 1 1998 - Dec 31 2010 and patients transplanted from Jan 1 1998 - Dec 3 2012...
April 15, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29656389/the-robustness-of-t-2-value-as-a-trabecular-structural-index-at-multiple-spatial-resolutions-of-7-tesla-mri
#8
D K Lee, Y K Song, B W Park, H P Cho, J S Yeom, G Cho, H Cho
PURPOSE: To evaluate the robustness of MR transverse relaxation times of trabecular bone from spin-echo and gradient-echo acquisitions at multiple spatial resolutions of 7 T. METHODS: The effects of MRI resolutions to T2 and T2* of trabecular bone were numerically evaluated by Monte Carlo simulations. T2 , T2*, and trabecular structural indices from multislice multi-echo and UTE acquisitions were measured in defatted human distal femoral condyles on a 7 T scanner...
April 15, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29656387/a-nationwide-analysis-of-30-day-adverse-events-unplanned-readmission-and-length-of-hospital-stay-after-peripheral-nerve-surgery-in-extremities-and-the-brachial-plexus
#9
Enrico Martin, Ivo S Muskens, Joeky T Senders, David J Cote, Timothy R Smith, Marike L D Broekman
BACKGROUND: Little is known on adverse events and their timing after peripheral nerve surgery in extremities. The aim of this study is to identify predictors and typical timing of complications, unplanned readmission, and length of hospital stay for patients undergoing peripheral nerve surgery in the extremities. METHODS: Data were extracted from the National Surgical Quality Improvement Program (NSQIP) registry from 2005 to 2015. Adult patients undergoing peripheral nerve surgery in the extremities were included...
April 15, 2018: Microsurgery
https://www.readbyqxmd.com/read/29656383/improved-method-for-estimating-reaction-rates-during-push-pull-tests
#10
Charles J Paradis, Emma R Dixon, Lauren M Lui, Adam P Arkin, Jack C Parker, Jonathan D Istok, Edmund Perfect, Larry D McKay, Terry C Hazen
The breakthrough curve obtained from a single-well push-pull test can be adjusted to account for dilution of the injection fluid in the aquifer fluid. The dilution-adjusted breakthrough curve can be analyzed to estimate the reaction rate of a solute. The conventional dilution-adjusted method assumes that the ratio of the concentrations of the non-reactive and reactive solutes in the injection fluid versus the aquifer fluid are equal. If this assumption is invalid, the conventional method will generate inaccurate breakthrough curves and may lead to erroneous conclusions regarding the reactivity of a solute...
April 15, 2018: Ground Water
https://www.readbyqxmd.com/read/29656321/multi-center-reproducibility-of-structural-diffusion-tensor-and-resting-state-functional-magnetic-resonance-imaging-measures
#11
S Deprez, Michiel B de Ruiter, S Bogaert, R Peeters, J Belderbos, D De Ruysscher, S Schagen, S Sunaert, P Pullens, E Achten
PURPOSE: The aim of this study is to assess multi-center reproducibility and longitudinal consistency of MRI imaging measurements, as part of a phase III longitudinal multi-center study comparing the neurotoxic effect following prophylactic cranial irradiation with hippocampal avoidance (HA-PCI), in comparison with conventional PCI in patients with small-cell lung cancer. METHODS: Harmonized MRI acquisition protocols from six participating sites and two different vendors were compared using both physical and human phantoms...
April 14, 2018: Neuroradiology
https://www.readbyqxmd.com/read/29656171/associations-between-birth-size-and-later-height-from-infancy-through-adulthood-an-individual-based-pooled-analysis-of-28-twin-cohorts-participating-in-the-codatwins-project
#12
Aline Jelenkovic, Yoshie Yokoyama, Reijo Sund, Yoon-Mi Hur, Jennifer R Harris, Ingunn Brandt, Thomas Sevenius Nilsen, Syuichi Ooki, Vilhelmina Ullemar, Catarina Almqvist, Patrik K E Magnusson, Kimberly J Saudino, Maria A Stazi, Corrado Fagnani, Sonia Brescianini, Tracy L Nelson, Keith E Whitfield, Ariel Knafo-Noam, David Mankuta, Lior Abramson, Tessa L Cutler, John L Hopper, Clare H Llewellyn, Abigail Fisher, Robin P Corley, Brooke M Huibregtse, Catherine A Derom, Robert F Vlietinck, Morten Bjerregaard-Andersen, Henning Beck-Nielsen, Morten Sodemann, Robert F Krueger, Matt McGue, Shandell Pahlen, S Alexandra Burt, Kelly L Klump, Lise Dubois, Michel Boivin, Mara Brendgen, Ginette Dionne, Frank Vitaro, Gonneke Willemsen, Meike Bartels, Catharina E M van Beijsterveld, Jeffrey M Craig, Richard Saffery, Finn Rasmussen, Per Tynelius, Kauko Heikkilä, Kirsi H Pietiläinen, Gombojav Bayasgalan, Danshiitsoodol Narandalai, Claire M A Haworth, Robert Plomin, Fuling Ji, Feng Ning, Zengchang Pang, Esther Rebato, Adam D Tarnoki, David L Tarnoki, Jina Kim, Jooyeon Lee, Sooji Lee, Joohon Sung, Ruth J F Loos, Dorret I Boomsma, Thorkild I A Sørensen, Jaakko Kaprio, Karri Silventoinen
BACKGROUND: There is evidence that birth size is positively associated with height in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. AIM: To analyze the associations of birth weight, length and ponderal index with height from infancy through adulthood within mono- and dizygotic twin pairs, which provides insights into the role of genetic and environmental individual-specific factors. METHODS: This study is based on the data from 28 twin cohorts in 17 countries...
April 12, 2018: Early Human Development
https://www.readbyqxmd.com/read/29656095/a-protocol-of-human-animal-interaction-to-habituate-young-sheep-and-goats-for-behavioural-studies
#13
P G González-Pech, C G Marín-Tun, D A Valladares-González, J Ventura-Cordero, G I Ortiz-Ocampo, R Cámara-Sarmiento, C Sandoval-Castro, J F J Torres-Acosta
Animal habituation is key to obtain reliable data on behavioural studies but detailed procedures to achieve it are scarce. This study designed a set of actions to habituate sheep and goats to human observers. Pelibuey sheep (n = 15) and Criollo goats (n = 10) were classified as (a) avoider, flight from human interaction, or (b) follower, seek human interaction. Habituation was measured by the reduction of flight distance by avoiders, or number of followers in the presence of observers. The habituation protocol consisted of a gradually increased series of five manoeuvres, either challenge (for avoiders) or evasion (for seekers), performed first inside a pen and subsequently in a grass paddock...
April 12, 2018: Behavioural Processes
https://www.readbyqxmd.com/read/29656080/an-nmr-strategy-to-detect-conformational-differences-in-a-protein-complexed-with-highly-analogous-inhibitors-in-solution
#14
John D Persons, Shahid N Khan, Rieko Ishima
This manuscript presents an NMR strategy to investigate conformational differences in protein-inhibitor complexes, when the inhibitors tightly bind to a protein at sub-nanomolar dissociation constants and are highly analogous to each other. Using HIV-1 protease (PR), we previously evaluated amide chemical shift differences, ΔCSPs, of PR bound to darunavir (DRV) compared to PR bound to several DRV analogue inhibitors, to investigate subtle but significant long-distance conformation changes caused by the inhibitor's chemical moiety variation [Khan, S...
April 12, 2018: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29656039/maternal-adherence-to-guidance-on-breast-milk-collection-process
#15
M Carré, D Dumoulin, R Jounwaz, B Mestdagh, V Pierrat
INTRODUCTION: Breast milk expression with a breast pump increases the risk of contaminating milk with pathogenic bacteria; how to decontaminate breast pumps is controversial. The aim of this study was to investigate maternal adherence to updated French guidance on the breast milk collection process, including breast pump decontamination, and to identify potential sources of increased bacterial counts in breast milk in order to improve prevention messages to mothers. METHODS: Descriptive prospective study conducted between November 2015 and April 2016 in a French tertiary perinatal center...
April 11, 2018: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29655929/aging-impairs-mitochondrial-respiratory-capacity-in-classical-monocytes
#16
Brandt D Pence, Johnathan R Yarbro
Aging is a critical healthcare concern, with age-related inflammation disposing individuals to a variety of diseases. Monocytes are affected by the aging process, with increased inflammation and impaired cellular functions such as phagocytosis. Mechanisms by which aging alters monocyte function are unknown, but recent research suggests that the balance of metabolic processes determine immune cell phenotype and function. Given the known association between aging and mitochondrial dysfunction in other tissues, we hypothesized that aging would impair mitochondrial function in monocytes...
April 12, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29655872/-contribution-of-the-scrotal-flap-for-the-coverage-of-ischial-and-perineal-pressure-ulcers
#17
M Vantomme, R Viard, R Aimard, P-L Vincent, J-P Comparin, D Voulliaume
INTRODUCTION: The ischiatric pressure sore is a common pathology in rehabilitated spinal cord injured people, despite careful prevention. Medical treatment by discharge and directed healing is not always sufficient and surgery using local musculocutaneous flaps is often essential. Unfortunately, recidivism is frequent and the availability of local flaps is limited. The scrotal flap is an excellent complement to classic flaps, gluteal flaps or hamstrings. It can be used alone or in addition to another musculocutaneous flap, in first or second intention...
April 11, 2018: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/29655837/outcomes-of-early-liver-transplantation-for-patients-with-severe-alcoholic-hepatitis
#18
Brian P Lee, Neil Mehta, Laura Platt, Ahmet Gurakar, John P Rice, Michael R Lucey, Gene Y Im, George Therapondos, Hyosun Han, David W Victor, Oren K Fix, Lisanne Dinges, Deepti Dronamraju, Christine Hsu, Michael D Voigt, Mary E Rinella, Haripriya Maddur, Sheila Eswaran, Jessica Hause, David Foley, R Mark Ghobrial, Jennifer L Dodge, Zhiping Li, Norah A Terrault
BACKGROUND & AIMS: The American Consortium of Early Liver Transplantation (LT) for Alcoholic Hepatitis comprises 12 centers from 8 United Network for Organ Sharing regions studying early LT (without mandated period of sobriety) for patients with severe alcoholic hepatitis (AH). We analyzed outcomes of these patients. METHODS: We performed a retrospective study of consecutive patients with a diagnosis of severe AH and no prior diagnosis of liver disease or episodes of AH, who underwent LT before 6 months of abstinence from 2006 through 2017 at 12 centers...
April 12, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29655829/renal-effects-and-associated-outcomes-during-angiotensin-neprilysin-inhibition-in-heart-failure
#19
Kevin Damman, Mauro Gori, Brian Claggett, Pardeep S Jhund, Michele Senni, Martin P Lefkowitz, Margaret F Prescott, Victor C Shi, Jean L Rouleau, Karl Swedberg, Michael R Zile, Milton Packer, Akshay S Desai, Scott D Solomon, John J V McMurray
OBJECTIVES: The purpose of this study was to evaluate the renal effects of sacubitril/valsartan in patients with heart failure and reduced ejection fraction. BACKGROUND: Renal function is frequently impaired in patients with heart failure with reduced ejection fraction and may deteriorate further after blockade of the renin-angiotensin system. METHODS: In the PARADIGM-HF (Prospective Comparison of ARNI with ACE inhibition to Determine Impact on Global Mortality and Morbidity in Heart Failure) trial, 8,399 patients with heart failure with reduced ejection fraction were randomized to treatment with sacubitril/valsartan or enalapril...
April 5, 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29655828/venoarterial-extracorporeal-membrane-oxygenation-in-cardiogenic-shock
#20
REVIEW
Mary E Keebler, Elias V Haddad, Chun W Choi, Stuart McGrane, Sandip Zalawadiya, Kelly H Schlendorf, D Marshall Brinkley, Matthew R Danter, Mark Wigger, Jonathan N Menachem, Ashish Shah, JoAnn Lindenfeld
Venoarterial extracorporeal membrane oxygenation has emerged as a viable treatment for patients in cardiogenic shock with biventricular failure and pulmonary dysfunction. Advances in pump and oxygenator technology, cannulation strategies, patient selection and management, and durable mechanical circulatory support have contributed to expanded utilization of this technology. However, challenges remain that require investigation to improve outcomes.
April 5, 2018: JACC. Heart Failure
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