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https://www.readbyqxmd.com/read/29929113/predicting-suicidal-behaviour-after-first-episode-of-non-affective-psychosis-the-role-of-neurocognitive-functioning
#1
M Canal-Rivero, J D López-Moríñigo, E Setién-Suero, M Ruiz-Veguilla, J L Ayuso-Mateos, R Ayesa-Arriola, B Crespo-Facorro
BACKGROUND: Suicide has been recognised as one of the major causes of premature death in psychosis. However, predicting suicidal behaviour (SB) is still challenging in the clinical setting and the association of neurocognition with SB in psychosis remains poorly understood. This study aimed to investigate the role of neurocognitive performance as predictor of SB. Also, we sought to explore differences in the evolution of clinical and neurocognitive functioning between participants with/without history of suicide attempts (SA) over follow-up period...
June 18, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29929069/a-novel-electron-microscopic-method-for-measurement-of-mineral-content-in-enamel-lesions
#2
C Fowler, R J M Lynch, D Shingler, D Walsh, C Carson, A Neale, R J Willson, A Brown
OBJECTIVE: To assess Scanning Electron Microscopy in Back-Scattered Emission mode (BSE-SEM) for measurement of lesion mineral content as a function of depth. Direct comparison is made with Transverse Micro-Radiography (TMR) and Surface Micro-Hardness (SMH) on carious and erosive lesions. DESIGN: Caries lesions prepared from sound bovine enamel at 37 °C and pH 4.6 in unsaturated (7d) or part-saturated (8d, 4.1 mM Ca2+ , 8 mM Pi) lactic acid /methyl cellulose gel system, followed by TMR analysis...
June 13, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29929044/nitric-oxide-induced-s-nitrosation-causes-base-excision-repair-imbalance
#3
Marcus C Parrish, Isaac A Chaim, Zachary D Nagel, Steven R Tannenbaum, Leona D Samson, Bevin P Engelward
It is well established that inflammation leads to the creation of potent DNA damaging chemicals, including reactive oxygen and nitrogen species. Nitric oxide can react with glutathione to create S-nitrosoglutathione (GSNO), which can in turn lead to S-nitrosated proteins. Of particular interest is the impact of GSNO on the function of DNA repair enzymes. The base excision repair (BER) pathway can be initiated by the alkyl-adenine DNA glycosylase (AAG), a monofunctional glycosylase that removes methylated bases...
May 5, 2018: DNA Repair
https://www.readbyqxmd.com/read/29929004/a-preliminary-study-of-astigmatism-and-early-childhood-development
#4
Erin M Harvey, Eileen R McGrath, Joseph M Miller, Amy L Davis, J Daniel Twelker, Leslie K Dennis
PURPOSE: To determine whether uncorrected astigmatism in toddlers is associated with poorer performance on the Bayley Scales of Infant and Toddler Development, 3rd edition (BSITD-III). METHODS: Subjects were 12- to 35-month-olds who failed an instrument-based vision screening at a well-child check. A cycloplegic eye examination was conducted. Full-term children with no known medical or developmental conditions were invited to participate in a BSITD-III assessment conducted by an examiner masked to the child's eye examination results...
June 18, 2018: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29928951/higher-serum-levels-of-pro-hepcidin-in-patients-with-parkinson-s-disease-treated-with-deep-brain-stimulation
#5
J Kwiatek-Majkusiak, M Geremek, D Koziorowski, R Tomasiuk, S Szlufik, A Friedman
Hepcidin is an essential hormone responsible for the systemic metabolism of iron and simultaneously belongs to the family of the protein mediators of the acute inflammatory response, primarily induced in response to interleukin 6. It can therefore be regarded as a link between the oxidative stress processes, where iron plays an important role, and the processes of neuroinflammation - both considered to be responsible for the neurodegeneration in Parkinson's disease. We assessed the serum level of pro-hepcidin in patients with Parkinson's disease treated only pharmacologically and those treated additionally with deep brain stimulation (DBS) as compared to the control group...
June 18, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29928946/long-term-impact-of-regional-nodal-irradiation-in-patients-with-node-positive-breast-cancer-treated-with-neoadjuvant-systemic-therapy
#6
Shane R Stecklein, Minjeong Park, Diane D Liu, Janeiro J Valle Goffin, Abigail S Caudle, Elizabeth A Mittendorf, Carlos H Barcenas, Sarah Mougalian, Wendy A Woodward, Vicente Valero, Aysegul A Sahin, Wei T Yang, Simona F Shaitelman
BACKGROUND: The impact of regional nodal irradiation (RNI) on locoregional recurrence (LRR) and any disease recurrence (DR) in women with node-positive breast cancer who receive neoadjuvant systemic therapy (NAT) is unknown. METHODS: The impact of RNI on LRR and DR was estimated with the cumulative incidence method in 1289 women with stage II-III breast cancer with cytologically confirmed axillary metastases who received NAT, 1989-2007. Multicovariate Cox regression analysis was performed to examine the effect of RNI after accounting for other predictive and prognostic variables...
June 18, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29928831/family-history-of-mi-smoking-and-risk-of-periodontal-disease
#7
Y H Yu, L Doucette-Stamm, J Rogus, K Moss, R Y L Zee, B Steffensen, P M Ridker, J E Buring, S Offenbacher, K Kornman, D I Chasman
Periodontal disease (PD) shares common risk factors with cardiovascular disease. Our hypothesis was that having a family history of myocardial infarction (FamHxMI) may be a novel risk factor for PD. Risk assessment based on FamHxMI, conditional on smoking status, was examined given the strong influence of smoking on PD. Exploratory analysis with inflammatory biomarkers and genetic determinants was conducted to understand potential mechanistic links. The Women's Genome Health Study (WGHS) is a prospective cohort of US female health care professionals who provided blood samples at baseline in the Women's Health Study, a 2 × 2 factorial clinical trial investigating vitamin E and aspirin in the prevention of cardiovascular disease and cancer...
June 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29928783/combinatorial-synthesis-of-new-pyrimidine-and-purine-%C3%A3-d-ribonucleoside-nucleolipids-their-distribution-between-aqueous-and-organic-phases-and-their-in-vitro-activity-against-human-and-rat-glioblastoma-cells-in-vitro
#8
Katharina Hammerbacher, Katharina Görtemaker, Christine Knies, Eugenia Bender, Gabriel A Bonaterra, Helmut Rosemeyer, Ralf Kinscherf
Two series of nucleolipids, (i) O-2',3'-heptanylidene- as well as O-2',3'-undecanylidene ketals of 6 ß-D-ribonucleosides (type A) and partly N-farnesyl derivatives thereof (type B) were prepared in a combinatorial manner. All novel compounds were characterized by elemental analysis and/or ESI mass spectrometry and by UV-, 1 H-, and 13 C-NMR spectroscopy. Conformational parameters of the nucleosides and nucleolipids were calculated from various 3 J(H,H), 3 J(1 H,13 C) and 5 J(F,H) coupling constants. For a drug profiling the parent nucleosides and their lipophilic derivatives were studied with respect to their distribution (log P) between water and n-octanol as well as water and cyclohexane...
June 21, 2018: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29928752/-results-of-the-assessment-procedure-for-dentists-with-a-foreign-degree-in-the-netherlands
#9
L R Kooij, W Davidse, M C D N J M Huysmans
During the period from 1 January 2007 to 1 January 2017, 138 dentists with a foreign dental degree (obtained outside the European Economic Area or Switzerland) who wanted to practice dentistry in the Netherlands have undertaken the assessment procedure to obtain a certificate of professional competence. The procedure comprises a Dutch language proficiency and communications test, followed by tests of competence specific to the dental profession. For 68 dentists (49%), no deficiencies in knowledge or skills were identified...
June 2018: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/29928684/collaborations-in-gynecologic-oncology-education-and-research-in-low-and-middle-income-countries-current-status-barriers-and-opportunities
#10
REVIEW
L Chuang, J Berek, T Randall, M McCormack, K Schmeler, R Manchanda, T Rebbeck, C J Jeng, D Pyle, M Quinn, E Trimble, R Naik, C H Lai, K Ochiai, L Denny, N Bhatla
Eighty-five percent of the incidents and deaths from cervical cancer occur in low and middle income countries. In many of these countries, this is the most common cancer in women. The survivals of the women with gynecologic cancers are hampered by the paucity of prevention, screening, treatment facilities and gynecologic oncology providers. Increasing efforts dedicated to improving education and research in these countries have been provided by international organizations. We describe here the existing educational and research programs that are offered by major international organizations, the barriers and opportunities provided by these collaborations and hope to improve the outcomes of cervical cancer through these efforts...
August 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29928680/aberrant-brain-bile-acid-signaling-and-cholesterol-accumulation-a-new-look-at-mechanisms-in-hepatic-encephalopathy
#11
EDITORIAL
Arumugam R Jayakumar, Michael D Norenberg
No abstract text is available yet for this article.
2018: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29928656/long-term-phase-1-2-intraspinal-stem-cell-transplantation-outcomes-in-als
#12
Stephen A Goutman, Morton B Brown, Jonathan D Glass, Nicholas M Boulis, Karl Johe, Tom Hazel, Merit Cudkowicz, Nazem Atassi, Lawrence Borges, Parag G Patil, Stacey A Sakowski, Eva L Feldman
Objective: Intraspinal human spinal cord-derived neural stem cell (HSSC) transplantation is a potential therapy for amyotrophic lateral sclerosis (ALS); however, previous trials lack controls. This post hoc analysis compared ambulatory limb-onset ALS participants in Phase 1 and 2 (Ph1/2) open-label intraspinal HSSC transplantation studies up to 3 years after transplant to matched participants in Pooled Resource Open-Access ALS Clinical Trials (PRO-ACT) and ceftriaxone datasets to provide required analyses to inform future clinical trial designs...
June 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29928652/cardiac-responses-to-viewing-facial-emotion-differentiate-frontotemporal-dementias
#13
Charles R Marshall, Christopher J D Hardy, Micah Allen, Lucy L Russell, Camilla N Clark, Rebecca L Bond, Katrina M Dick, Emilie V Brotherhood, Jonathan D Rohrer, James M Kilner, Jason D Warren
Objective: To establish proof-of-principle for the use of heart rate responses as objective measures of degraded emotional reactivity across the frontotemporal dementia spectrum, and to demonstrate specific relationships between cardiac autonomic responses and anatomical patterns of neurodegeneration. Methods: Thirty-two patients representing all major frontotemporal dementia syndromes and 19 healthy older controls performed an emotion recognition task, viewing dynamic, naturalistic videos of facial emotions while ECG was recorded...
June 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29928585/autoimmune-encephalitis-associated-with-two-antibodies
#14
Nikolai Gil D Reyes, Mario B Prado, Christian Wilson R Turalde, Marc Laurence L Fernandez
•In patients presenting with clinical manifestations of encephalitis without clinical or laboratory signs of infection, an autoimmune etiology should be suspected.•Antibodies for various neural antigens may coexist, thus a complete and clinically-guided autoimmune panel must be done in suspected cases of autoimmune encephalitis.•Tumor resection, if applicable, combined with high dose steroids and immunotherapy are effective treatment strategies for autoimmune encephalitis with coexisting antibodies.
2018: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/29928179/necrotizing-enterocolitis-in-two-siblings-and-an-unrelated-infant-with-overlapping-chromosome-6q25-deletions
#15
Hannah C D Esdal, Muhammad B Ghbeis, Daniel A Saltzman, Donavon Hess, Janet R Hume, Robyn C Reed, Susan A Berry, Eric Hoggard, Betsy Hirsch, Linda B Baughn, Lisa A Schimmenti
The pathogenesis of necrotizing enterocolitis (NEC) remains poorly understood but is thought to be multifactorial. There are no specific recurring chromosomal abnormalities previously associated with NEC. We report 3 cases of intestinal necrosis associated with large chromosome 6 deletions. The first patient was found to have a 7.9-Mb deletion of chromosome 6 encompassing over 40 genes, arr[GRCh37] 6q25.3q26(155699183_163554531)×1. The second patient had a 19.5-Mb deletion of chromosome 6 generated by an unbalanced translocation with chromosome 18, 46,XY,der(6)t (6;18)(q25...
May 2018: Molecular Syndromology
https://www.readbyqxmd.com/read/29928070/gantry-rotational-motion-induced-blur-in-cone-beam-computed-tomography
#16
J Krebs, A Shankar, D R Bednarek, S Rudin
As neuro-endovascular image-guided interventions (EIGIs) make use of higher resolution detectors, gantry rotational motion-induced blur becomes more noticeable in acquired projections as well as reconstructed images by reducing the visibility of vascular and device features whose visualization could be critical in the treatment of vascular pathology. Motion-induced blur in projections views is a function of an object's position in the field-of-view (FOV), gantry rotational speed, and frame capture or exposure time...
February 2018: Proceedings of SPIE
https://www.readbyqxmd.com/read/29927954/genetic-variation-and-population-structure-of-diaphorina-citri-using-cytochrome-oxidase-i-sequencing
#17
A Fuentes, W E Braswell, R Ruiz-Arce, A Racelis
Citrus greening disease, or huanglongbing (HLB), is currently one of the most devastating diseases of citrus. The bacteria thought to be responsible for the disease, Candidatus Liberibacter asiaticus impact the majority of commercial citrus species worldwide. These bacteria are transmitted by the Asian citrus psyllid (ACP), Diaphorina citri Kuwayama, which is now found in most citrus growing regions. With no known cure, ACP-vectored HLB is responsible for significant economic losses to the global citrus industry...
2018: PloS One
https://www.readbyqxmd.com/read/29927900/strategies-for-improving-hepatitis-c-treatment-access-in-the-united-states-state-officials-address-high-drug-prices-stigma-and-building-treatment-capacity
#18
Shashi N Kapadia, Carrie D Johnston, Kristen M Marks, Bruce R Schackman, Erika G Martin
CONTEXT: Curative treatments for hepatitis C virus (HCV) can alter the course of a devastating epidemic, but high drug prices have contributed to restrictions on HCV treatment access. OBJECTIVE: We aimed to learn how state health agencies have responded to the challenges of treatment access for HCV. DESIGN: Qualitative study using semistructured key informant interviews focused on aspects of HCV treatment access between June 2016 and March 2017...
June 20, 2018: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/29927894/body-weight-and-mood-state-modifications-in-mixed-martial-arts-an-exploratory-pilot
#19
Ricardo Brandt, Guilherme G Bevilacqua, Danilo R Coimbra, Luiz C Pombo, Bianca Miarka, Andrew M Lane
Brandt, R, Bevilacqua, GG, Coimbra, DR, Pombo, LC, Miarka, B, and Lane, AM. Body weight and mood state modifications in mixed martial arts: An exploratory pilot. J Strength Cond Res XX(X): 000-000, 2018-Mixed martial arts (MMA) fighters typically use rapid weight loss (RWL) as a strategy to make competition weight. The aim of the present study was to compare body weight and mood changes in professional male MMA athletes who used strategies to rapidly lose weight (n = 9) and with MMA athletes who did not (n = 3)...
June 20, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29927888/comparison-of-multifrequency-bioelectrical-impedance-vs-dual-energy-x-ray-absorptiometry-for-assessing-body-composition-changes-after-participation-in-a-10-week-resistance-training-program
#20
Brad J Schoenfeld, Brett S Nickerson, Colin D Wilborn, Stacie L Urbina, Sara B Hayward, James Krieger, Alan A Aragon, Grant M Tinsley
Schoenfeld, BJ, Nickerson, BS, Wilborn, CD, Urbina, SL, Hayward, SB, Krieger, J, Aragon, AA, and Tinsley, G. Comparison of multifrequency bioelectrical impedance vs. dual-energy x-ray absorptiometry for assessing body composition changes after participation in a 10-week resistance training program. J Strength Cond Res XX(X): 000-000, 2018-The purpose of this study was to assess the ability of multifrequency bioelectrical impedance analysis (MF-BIA) to determine alterations in total and segmental body composition across a 10-week resistance training (RT) program in comparison with the criterion reference dual-energy X-ray absorptiometry (DXA)...
June 20, 2018: Journal of Strength and Conditioning Research
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