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Trypanasoma cruzi

Irem Atay, Hasan Kirmizibekmez, Marcel Kaiser, Galip Akaydin, Erdem Yesilada, Deniz Tasdemir
Context Some Ajuga L. (Lamiaceae) species are traditionally used for the treatment of malaria, as well as fever, which is a common symptom of many parasitic diseases. Objective In the continuation of our studies on the identification of antiprotozoal secondary metabolites of Turkish Lamiaceae species, we have investigated the aerial parts of Ajuga laxmannii. Materials and methods The aerial parts of A. laxmannii were extracted with MeOH. The H2O subextract was subjected to polyamide, C18-MPLC and SiO2 CCs to yield eight metabolites...
September 2016: Pharmaceutical Biology
Annabeth Fieck, Ivy Hurwitz, Angray S Kang, Ravi Durvasula
The parasite Trypanasoma cruzi is responsible for Chagas disease and its triatomine vector, Rhodnius prolixus, has a symbiotic relationship with the soil bacterium, Rhodococcus rhodnii. R. rhodnii that was previously genetically engineered to produce the anti-microbial peptide, cecropin A was co-infected with T. cruzi into R. prolixus resulting in clearance of the infectious T. cruzi in 65% of the vectors. Similar anti-microbial peptides have been isolated elsewhere and were studied for differential toxicity against T...
August 2010: Experimental Parasitology
María Cristina Mallimaci, Sergio Sosa-Estani, Graciela Russomando, Zunilda Sanchez, Carina Sijvarger, Isabel Marcela Alvarez, Lola Barrionuevo, Carlos Lopez, Elsa Leonor Segura
Chagas' disease, or American trypanosomiasis, is caused by the protozoan parasite Trypanasoma cruzi. It is estimated that 15,000 new cases of congenital T. cruzi transmission occur in the Americas each year. The aim of this study was to estimate the rate of congenital T. cruzi infection in infants born to infected women living in Ushuaia, Argentina, as well to assess a serologic test using Shed Acute Phase Antigen (SAPA) for a timely diagnosis of congenital infection. The rate of congenital infection among children in the study was 4...
January 2010: American Journal of Tropical Medicine and Hygiene
Sergio Martínez-Luis, Gina Della-Togna, Phyllis D Coley, Thomas A Kursar, William H Gerwick, Luis Cubilla-Rios
Bioassay-directed fractionation of extracts from the fermentation broth and mycelium of the fungus Edenia sp. led tothe isolation of five antileishmanial compounds, preussomerin EG1 (1), palmarumycin CP2 (2), palmarumycin CP17 (3), palmarumycin CP18 (4), and CJ-12,371 (5). Compounds 3 and 4 are new natural products, and this is only the second report of compound 1. The structures of compounds 1-5 were established by spectroscopic analyses (HRMS and NMR). All metabolites caused significant inhibition of the growth of Leishmania donoVani in the amastigote form, with IC50 values of 0...
December 2008: Journal of Natural Products
Juan Carlos Pizarro, Lori Stevens
BACKGROUND: Feeding patterns of the vector are important in the epidemiology of Chagas disease, the leading cause of heart disease in Latin America. Chagas disease is caused by the parasite, Trypanasoma cruzi, which is transmitted by blood feeding insects. Historically, feeding behaviours of haematophagous insects have been investigated using serological reactions, which have detection limits in terms of both taxonomic resolution, and quantity and quality of the blood meal. They are labor intensive, require technical expertise, need fresh or frozen samples and antibodies often are either not available commercially or the resources for synthesis and purification are not available...
2008: PloS One
Paz María Salazar, Gloria Rojas, Martha Bucio, Margarita Cabrera, Guadalupe García, Adela Ruiz, Yolanda Guevara, Roberto Tapia
OBJECTIVES: To determine the prevalence of Trypanasoma cruzi antibodies among the population under 18 years of age in the state of Veracruz, Mexico, and to identify risk factors associated with housing conditions and vector presence and distribution. METHODS: A cross-sectional, epidemiological study of the population under 18 years of age living in 10 of the 11 health districts of the state of Veracruz, Mexico, from 2000 to 2001. Presence of T. cruzi antibodies was determined by hemagglutination inhibition test (HAI) and enzyme-linked immunosorbent assays (ELISA) of serum samples spotted on filter paper, and confirmed by HAI, ELISA, and indirect immunofluorescence assay (IFA) on serum samples...
August 2007: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
Jose L Gonzalez, Chad E Stephens, Tanja Wenzler, Reto Brun, Farial A Tanious, W David Wilson, Todd Barszcz, Karl A Werbovetz, David W Boykin
A series of bis-2,5-[4-guanidinophenyl]thiophenes were prepared in a five step process starting from 2,5-bis[trimethylstannyl]thiophene. The compounds were evaluated in vitro against Trypanosoma brucei rhodesiense (T. b. r.), Plasmodium falciparum (P. f.), Leshmania donovani (L. d.) and Trypanasoma cruzi (T. c.), and in vivo against T. b. r. Certain compounds show promising in vitro activity against T. b. r. and P. f. and have superior in vivo activity against T. b. r. to that of pentamidine and furamidine.
April 2007: European Journal of Medicinal Chemistry
Hoon-Ji Helen Choi, Marcia Cornford, Lina Wang, Julie Sun, Theodore C Friedman
Although intrinsic pituitary lesions are the most common cause of hypopituitarism, suprasellar masses can produce similar symptoms. The differential diagnosis of a suprasellar mass includes cystic lesions, tumors, granulomatous disease, and infection. The etiology is not always obvious, and despite extensive work-up, may remain elusive. A 28-year-old Mexican man presented with complaints of headache and weakness for two weeks duration. He became increasingly lethargic and an MRI revealed a two centimeter suprasellar mass...
2004: Pituitary
Joshua Howarth, Darragh Wilson
1,4-Dihydroxy-2,3-dioxatricyclo[,9)]tetradecane and derivatives have been synthesised and their in vitro activity against Plasmodium falciparum (malaria) Ghana, Trypanasoma b brucei (sleeping sickness) TB-1, and Trypanasoma cruzi (Chagas' disease) TC-1, and Leishmaniasis infantum (leishmaniasis) L1 parasite strains has been assessed.
June 16, 2003: Bioorganic & Medicinal Chemistry Letters
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