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Journal of clinical oncology meta analysis

Michael D Jenkinson, Damiano Giuseppe Barone, Andrew Bryant, Luke Vale, Helen Bulbeck, Theresa A Lawrie, Michael G Hart, Colin Watts
BACKGROUND: Extent of resection is considered to be a prognostic factor in neuro-oncology. Intraoperative imaging technologies are designed to help achieve this goal. It is not clear whether any of these sometimes very expensive tools (or their combination) should be recommended as standard care for people with brain tumours. We set out to determine if intraoperative imaging technology offers any advantage in terms of extent of resection over standard surgery and if any one technology was more effective than another...
January 22, 2018: Cochrane Database of Systematic Reviews
Ionut Negoi, Sorin Hostiuc, Ruxandra Irina Negoi, Mircea Beuran
AIM: To compare the effectiveness of laparoscopic complete mesocolic excision (CME) with central vascular ligation (L-CME) with its open (O-CME) counterpart. METHODS: We conducted an electronic search of the PubMed/MEDLINE, Excerpta Medica Database, Web of Science Core Collection, Cochrane Center Register of Controlled Trails, Cochrane Database of Systematic Reviews, SciELO, and Korean Journal databases from their inception until May 2017. We considered randomized controlled trials (RCTs) and controlled clinical trials (CCTs) that included patients with colonic cancer comparing L-CME and O-CME...
December 15, 2017: World Journal of Gastrointestinal Oncology
Krishnan Vengadaragava Chary, Anita Ramesh
Objective: The objective of this study is to assess the postmarketing status: Efficacy and safety drugs and biologics related with cancer approved under expedited review. Methods: This observational, analytical study was carried between January and April 2016 by the Department of Pharmacology and Medical Oncology, Saveetha Medical College. Drugs approved under expedited review, fast-track status and its association with anti-cancer effects, postmarketing efficacy and safety, propensity to induce the second tumor was noted...
October 2017: Perspectives in Clinical Research
Saurabh Parasramka, Goutham Talari, Myrna Rosenfeld, Jing Guo, John L Villano
BACKGROUND: Recurrent high-grade glioma (HGG) carries an extremely poor prognosis. There is no current standard of care or guideline-based recommendations. Nitrosourea-based multidrug chemotherapy or PCV - procarbazine, lomustine (CCNU) and vincristine - is one of the treatment options at recurrence. There has been no meta-analysis which looks at the benefits and harms of PCV chemotherapy in adults with recurrent HGG. OBJECTIVES: To assess the effectiveness and safety of procarbazine, lomustine, and vincristine (PCV) chemotherapy with other interventions in adults with recurrent high-grade glioma...
July 26, 2017: Cochrane Database of Systematic Reviews
Jonathan Holmes, David Herrmann, Chelsea Koller, Sarah Khan, Blake Umberham, Jody A Worley, Matt Vassar
Systematic reviews synthesize data across multiple studies to answer a research question, and an important component of the review process is to evaluate the heterogeneity of primary studies considered for inclusion. Little is known, however, about the ways that systematic reviewers evaluate heterogeneity, especially in clinical specialties like oncology. We examined a sample of systematic reviews from this body of literature to determine how meta-analysts assessed and reported heterogeneity. A PubMed search of 6 oncology journals was conducted to locate systematic reviews and meta-analyses...
April 2017: Proceedings of the Baylor University Medical Center
Holger Cramer, Romy Lauche, Petra Klose, Silke Lange, Jost Langhorst, Gustav J Dobos
BACKGROUND: Breast cancer is the cancer most frequently diagnosed in women worldwide. Even though survival rates are continually increasing, breast cancer is often associated with long-term psychological distress, chronic pain, fatigue and impaired quality of life. Yoga comprises advice for an ethical lifestyle, spiritual practice, physical activity, breathing exercises and meditation. It is a complementary therapy that is commonly recommended for breast cancer-related impairments and has been shown to improve physical and mental health in people with different cancer types...
January 3, 2017: Cochrane Database of Systematic Reviews
Caroline Brard, Gwénaël Le Teuff, Marie-Cécile Le Deley, Lisa V Hampson
Background Bayesian statistics are an appealing alternative to the traditional frequentist approach to designing, analysing, and reporting of clinical trials, especially in rare diseases. Time-to-event endpoints are widely used in many medical fields. There are additional complexities to designing Bayesian survival trials which arise from the need to specify a model for the survival distribution. The objective of this article was to critically review the use and reporting of Bayesian methods in survival trials...
February 2017: Clinical Trials: Journal of the Society for Clinical Trials
Riaz A Agha, Alexander J Fowler, Thomas E Pidgeon, Georgina Wellstead, Dennis P Orgill
INTRODUCTION: One in eight women will develop breast cancer in their lifetime. Reconstruction is routinely offered to patients and can be autologous and/or implant based. One area of growing interest in autologous fat grafting (AFG). Our group recently published a systematic review and meta-analysis of this topic which showed 51 different outcomes were being utilized in the published literature, with substantial heterogeneity in their definitions. METHODS AND ANALYSIS: A Delphi consensus exercise amongst key stakeholders will be conducted using the long list of 51 outcomes generated through our previous work...
July 2016: International Journal of Surgery
Sarah Batson, Gemma Greenall, Pollyanna Hudson
BACKGROUND: Meta-analysis is a growing approach to evidence synthesis and network meta-analysis in particular represents an important and developing method within Health Technology Assessment (HTA). Meta-analysis of survival data is usually performed using the individual summary statistic-the hazard ratio (HR) from each randomised controlled trial (RCT). OBJECTIVES: The objectives of this study are to: (i) review the methods and reporting of survival analyses in oncology RCTs; and (ii) assess the suitability and relevance of survival data reported in RCTs for inclusion into meta-analysis...
2016: PloS One
Mariana Scaranti, Gilberto de Castro Júnior, Ana Oliveira Hoff
PURPOSE OF REVIEW: This article provides a background for an evidence-based decision regarding the prescription of vitamin D for cancer prevention and improvement of outcomes in oncology. RECENT FINDINGS: In 2014, Feldman and colleagues published a review suggesting a beneficial role for vitamin D in cancer development. In the same year, a Cochrane meta-analysis that included 18 randomized clinical trials comparing vitamin D administration versus no intervention in healthy population found no difference regarding cancer incidence between the groups...
May 2016: Current Opinion in Oncology
Michael E Bibens, A Benjamin Chong, Matt Vassar
OBJECTIVE: To evaluate the use of clinical trials registries in published obstetrics and gynecologic systematic reviews and meta-analyses. METHODS: We performed a metaepidemiologic study of systematic reviews between January 1, 2007, and December 31, 2015, from six obstetric and gynecologic journals (Obstetrics & Gynecology, Obstetrical & Gynecological Survey, Human Reproduction Update, Gynecologic Oncology, British Journal of Obstetrics and Gynaecology, and American Journal of Obstetrics & Gynecology)...
February 2016: Obstetrics and Gynecology
Sarah E Cousins, Emma Tempest, David J Feuer
BACKGROUND: This is an update of the original Cochrane review published in Issue 4, 2000. Intestinal obstruction commonly occurs in progressive advanced gynaecological and gastrointestinal cancers. Management of these patients is difficult due to the patients' deteriorating mobility and function (performance status), the lack of further chemotherapeutic options, and the high mortality and morbidity associated with palliative surgery. There are marked variations in clinical practice concerning surgery in these patients between different countries, gynaecological oncology units and general hospitals, as well as referral patterns from oncologists under whom these patients are often admitted...
January 4, 2016: Cochrane Database of Systematic Reviews
Hua Tu, He Huang, Jihong Liu
OBJECTIVE: To systematically review the clinical value of sentinel lymph node biopsy (SLNB) in diagnosis of lymph node metastasis in early-stage squamous cell carcinoma of vulva. METHODS: Cochrane library, biomedical database (EMbase), PubMed, China national knowledge internet (CNKI), Wang Fang database, «Gynecologic Oncology», «National Medical Journal of China» and «Chinese Journal of Obstetrics and Gynecology» were searched for literatures from 1990 to 2014 concerning SLNB application in early-stage vulvar squamous cell carcinoma...
September 1, 2015: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Wei-Guang Wang, Chao Wan, Guang-Jun Liao
OBJECTIVE: To evaluate whether the efficacy of high-dose chemotherapy in the treatment of primary well-differentiated osteosarcoma is superior to moderate-dose chemotherapy. METHODS: Cochrane systematic review method was used to retrieve literatures from MEDLINE, Embase, OVID, Cochrane Library database of clinical trials, Chinese Biomedical Literature Database CD-ROM, as well as manual searching from "China Oncology", "Chinese Journal of Clinical Oncology", "Cancer" etc...
2015: International Journal of Clinical and Experimental Medicine
Shaoxing Sun, Zonghuan Li, Li Sun, Chunxu Yang, Zijie Mei, Wen Ouyang, Bo Yang, Conghua Xie
This meta-analysis aimed to evaluate the currently available evidence on the efficacy and safety of cancer treatment with or without tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-related agents. We conducted a systematic search through Medline, Cochrane Library and EMBASE electronic databases and manually searched the Journal of Clinical Oncology to identify randomized controlled trials (RCTs) conducted between 1995 and 2013 comparing the efficacy and safety results of cancer treatment with and without TRAIL-related agents...
May 2014: Molecular and Clinical Oncology
Damiano Giuseppe Barone, Theresa A Lawrie, Michael G Hart
BACKGROUND: Extent of resection is believed to be a key prognostic factor in neuro-oncology. Image guided surgery uses a variety of tools or technologies to help achieve this goal. It is not clear whether any of these, sometimes very expensive, tools (or their combination) should be recommended as part of standard care for patient with brain tumours. We set out to determine if image guided surgery offers any advantage in terms of extent of resection over surgery without any image guidance and if any one tool or technology was more effective...
January 28, 2014: Cochrane Database of Systematic Reviews
Kenneth Jaaback, Nick Johnson, Theresa A Lawrie
BACKGROUND: Ovarian cancer tends to be chemosensitive and confine itself to the surface of the peritoneal cavity for much of its natural history. These features have made it an obvious target for intraperitoneal (IP) chemotherapy. Chemotherapy for ovarian cancer is usually given as an intravenous (IV) infusion repeatedly over five to eight cycles. Intraperitoneal chemotherapy is given by infusion of the chemotherapeutic agent directly into the peritoneal cavity. There are biological reasons why this might increase the anticancer effect and reduce some systemic adverse effects in comparison to IV therapy...
November 9, 2011: Cochrane Database of Systematic Reviews
Michael G Hart, Robert Grant, Ruth Garside, Gabriel Rogers, Margaret Somerville, Ken Stein
BACKGROUND: Standard treatment for high grade glioma (HGG) usually entails surgery (either biopsy or resection) followed by radiotherapy plus or minus temozolomide. Implanting wafers impregnated with chemotherapy agents into the resection cavity represents a novel means of delivering drugs directly to the resection cavity with potentially fewer systemic side effects. It is not clear how effective this modality is or whether it should be recommended as part of standard care for patients with HGG...
2011: Cochrane Database of Systematic Reviews
Shuang-nian Xu, Jie-ping Chen, Jian-ping Liu, Yun Xia
BACKGROUND: The studies have demonstrated that arsenic trioxide (ATO) in combination with all-trans retinoic acid (ATRA) takes effects in treatment of acute promyelocytic leukemia (APL) through different underlying mechanisms. This has established the molecular foundation of ATO plus ATRA therapy. Currently, ATO plus ATRA has also been widely used in clinical practice. OBJECTIVE: To assess the efficacy and safety of ATO in combination with ATRA for APL. SEARCH STRATEGY: The Cochrane Library (Issue 1, 2009), Cochrane Central Register of Controlled Trials (from 1970 to January 2009), MEDLINE (from 1978 to October 2008), EMBASE (from 1950 to March 2009), Chinese Biological Medical Literature Database (from 1978 to December 2008), CNKI (from 1994 to December 2008), China Medical Academic Conference Database (from 1994 to December 2008) were electronically searched...
November 2009: Zhong Xi Yi Jie He Xue Bao, Journal of Chinese Integrative Medicine
Andreas Lundh, Sebastiaan L Knijnenburg, Anders W Jørgensen, Elvira C van Dalen, Leontien C M Kremer
BACKGROUND: To ensure evidence-based decision making in pediatric oncology systematic reviews are necessary. The objective of our study was to evaluate the methodological quality of all currently existing systematic reviews in pediatric oncology. METHODS: We identified eligible systematic reviews through a systematic search of the literature. Data on clinical and methodological characteristics of the included systematic reviews were extracted. The methodological quality of the included systematic reviews was assessed using the overview quality assessment questionnaire, a validated 10-item quality assessment tool...
December 2009: Cancer Treatment Reviews
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