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https://www.readbyqxmd.com/read/28650129/in-vitro-efficacy-and-in-silico-analysis-of-cefixime-ofloxacin-combination-for-salmonella-typhi-from-bloodstream-infection
#1
Yamuna Devi Bakthavatchalam, Thirumal Kumar D, Iftikhar Aslam Tayubi, Baby Abirami S, Priyanka Babu, Elakkiya Munusamy, Bhuvaneswari Thukkaram, Raji Ravi, George Priya Doss C, Balaji Veeraraghavan
AIMS: Recently, the cefixime-ofloxacin combination is approved by drug controller general of India (DCGI) to treat typhoid fever. We sought to evaluate the antimicrobial activity of cefixime-ofloxacin combination against S. Typhi. METHODS AND RESULTS: 283 non-duplicate S. Typhi isolates collected during 2012 to 2014 were included in this study. Minimum inhibitory concentration (MIC) of cefixime and ofloxacin was determined by using broth microdilution method. Combinational testing was performed by using checkerboard assay...
June 26, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28607209/physical-growth-morbidity-profile-and-mortality-among-healthy-late-preterm-neonates
#2
Priyanka Gupta, Ritu Mital, Bimlesh Kumar, Ajeet Yadav, Mohit Jain, Amit Upadhyay
OBJECTIVE: To compare the physical growth outcomes, morbidity profile and mortality at an age of 12 months among late preterm (34 0/7to 36 6/7) neonates to term (37 0/7to 41 6/7) neonates. STUDY DESIGN: A prospective cohort study. SETTING: A tertiary care center of Northern India during 2014-2015. PARTICIPANTS: 200 apparently healthy late preterms and term infants, followed up to 12 months of age. MAIN OUTCOME MEASURES: Physical growth parameters, morbidity profile and mortality...
June 4, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28525510/zika-virus-obstetric-and-pediatric-anesthesia-considerations
#3
Jacqueline L Tutiven, Benjamin T Pruden, James S Banks, Mario Stevenson, David J Birnbach
As of November 2016, the Florida Department of Health (FDH) and the Centers for Disease Control and Prevention have confirmed more than 4000 travel-related Zika virus (ZIKV) infections in the United States with >700 of those in Florida. There have been 139 cases of locally acquired infection, all occurring in Miami, Florida. Within the US territories (eg, Puerto Rico, US Virgin Islands), >30,000 cases of ZIKV infection have been reported. The projected number of individuals at risk for ZIKV infection in the Caribbean and Latin America approximates 5 million...
June 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28523896/hemophagocytic-lymphohistiocytosis-in-a-newborn-presenting-as-blueberry-muffin-baby
#4
Krista N Larson, Sergio R Gaitan, Benjamin J Stahr, Dean S Morrell
Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening hyperinflammatory syndrome characterized by uncontrolled activation and proliferation of proinflammatory cytokines. Initial presentation commonly includes fever, hepatosplenomegaly, and pancytopenia; 6 to 65% of cases also have a concurrent cutaneous eruption. We present the case of a 6-day-old premature infant boy with congenital severe thrombocytopenia, anemia, and hepatosplenomegaly who presented with several cutaneous violaceous papules and nodules and was found to have HLH...
May 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28489765/anesthetic-management-of-cesarean-delivery-in-parturients-with-ruptured-sinus-of-valsalva-aneurysm-care-compliant-2-case-reports-and-literature-review
#5
Gang Fang, Man Li, Jian Li, Li Lin, Wei Mei
RATIONALE: Ruptured sinus of Valsalva aneurysm is rare and dangerous in parturients. Few cases of ruptured SVA in pregnancy are reported, and the anesthetic management for cesarean delivery has scarcely been described. PATIENT CONCERNS: A parturient at 37-week gestation complained of a sore throat and cough that started 3 days before admission, followed 1 day later by fever, dizziness, breathlessness, and palpitation on exertion. Case two at 36-week gestation complained of a 1-day history of bloating in the lower abdomen...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28473508/uk-parents-attitudes-towards-meningococcal-group-b-menb-vaccination-a-qualitative-analysis
#6
Cath Jackson, Joanne Yarwood, Vanessa Saliba, Helen Bedford
OBJECTIVES: (1) To explore existing knowledge of, and attitudes, to group B meningococcal disease and serogroup B meningococcal (MenB) vaccine among parents of young children. (2) To seek views on their information needs. DESIGN: Cross-sectional qualitative study using individual and group interviews conducted in February and March 2015, prior to the introduction of MenB vaccine (Bexsero) into the UK childhood immunisation schedule. SETTING: Community centres, mother and toddler groups, parents' homes and workplaces in London and Yorkshire...
May 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28412977/noma-as-a-complication-of-false-teeth-ebiino-extraction-a-case-report
#7
Martin Tungotyo
BACKGROUND: Ebiino, also known as false tooth extraction, is a traditional practice done mainly in the remote areas of African countries, including Uganda. It involves the extraction of tooth buds in babies with common childhood illnesses such as fever, cough, and diarrhea. It is thought that the tooth buds are responsible for the ailments seen in these infants. The practice is performed by traditional healers using unsterile instruments. The complications associated with this dangerous practice have been mentioned in the literature and include anemia and septicemia, among others...
April 17, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28399895/impact-of-maternal-respiratory-infections-on-low-birth-weight-a-community-based-longitudinal-study-in-an-urban-setting-in-pakistan
#8
Asad Ali, Umber Zaman, Sadia Mahmud, Gul-E-Shehwar Zahid, Momin Kazi, William A Petri, Zulfiqar Bhutta, Anita Zaidi, Molly A Hughes
BACKGROUND: The health of mothers and their newborns is intricately related. The weight of the infant at birth is a powerful predictor of infant growth and survival, and is considered to be partly dependent on maternal health and nutrition during pregnancy. We conducted a longitudinal study in an urban community within Karachi to determine maternal predictors of newborn birth weight. METHODS: Four hundred pregnant women were enrolled in the study during the period 2011-2013...
April 11, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28377661/awareness-of-lebanese-pediatricians-regarding-children-s-oral-health
#9
Nahla Nassif, Balsam Noueiri, Riad Bacho, Kassem Kassak
Pediatricians have an important role in early identification and prevention of oral health, but they reported lack of knowledge in this field. AIM: the aim of the study is to evaluate the knowledge and attitudes of Lebanese pediatricians regarding children's oral health. MATERIALS AND METHODS: A cross sectional study including 100 Lebanese pediatricians was performed. They answered 21 questions. Three variables were taken into consideration: The number of years in practice, the place and type of practice...
January 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28279094/pre-hospital-assessment-of-a-child-under-one-year-old-with-fever
#10
Ann Wilkinson
Parents often bring children with a fever to primary and emergency care settings. This article uses a case study to explore the assessment of children with a fever in pre-hospital settings using the three-minute toolkit, National Institute for Health and Care Excellence fever guidelines and the baby check score. It also highlights some educational resources for parents, designed to help them recognise when to seek clinical advice for their children.
March 10, 2017: Emergency Nurse: the Journal of the RCN Accident and Emergency Nursing Association
https://www.readbyqxmd.com/read/28188933/zika-virus-shedding-in-human-milk-during-lactation-an-unlikely-source-of-infection
#11
Marta G Cavalcanti, Mauro J Cabral-Castro, Jorge L S Gonçalves, Larissa S Santana, Eduardo Scarlatelli Pimenta, José M Peralta
Zika virus (ZIKV) transmission through non-mosquito-dependent routes has become increasingly important since reports of sexual transmission. Breastfeeding is a potential means of ZIKV transmission, but data on this remain limited. The cases of four mothers with laboratory-proven infections are reported. No disease evolved in three of the breastfed babies despite detectable maternal viremia and viruria, the presence of viral RNA shedding, and the isolation of infective particles in one milk sample. Fever and rash in one infant of a ZIKV-infected mother proved to be related to chikungunya virus infection...
April 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28148289/a-rare-case-of-dengue-encephalopathy-complicating-a-term-pregnancy
#12
Lavanya Rajagopala, Ravindra L Satharasinghe, Madhava Karunarathna
BACKGROUND: Dengue fever has an expanded clinical spectrum ranging from an asymptomatic infection to life threatening dengue hemorrhagic fever and refractory shock. Dengue infection in pregnancy can be a diagnostic dilemma, particularly considering the physiological changes in pregnancy and the obstetric complications encountered in clinical practice. Hence the knowledge of its diagnosis and management in its atypical presentations is of paramount importance. Here we report an unusual case of uncomplicated dengue encephalopathy in a term mother, probably the first to be reported from the Indian subcontinent...
February 2, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28137229/challenges-with-mosquito-borne-viral-diseases-outbreak-of-the-monsters
#13
Renu Gautam, Sweta Mishra, Archana Milhotra, Ritika Nagpal, Mradul Mohan, Anchal Singhal, Pratibha Kumari
The viruses responsible for mosquito-borne diseases are on an exploring mode, expanding their horizon, adapting to the situation and comfortably making their presence felt globally, from South Africa to Asia, Europe and United States. The current global scenario and recent documentations indicate towards the real monsters, outbreak of Zika, dengue and chikungunya viruses. Zika, dengue and chikungunya viruses, all three are positive sense single-stranded RNA arbovirus and so their initial symptoms are almost 80% similar and all three are spread by mosquitos which bite during the day...
January 30, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28077740/the-jarisch-herxheimer-reaction-after-antibiotic-treatment-of-spirochetal-infections-a-review-of-recent-cases-and-our-understanding-of-pathogenesis
#14
REVIEW
Thomas Butler
Within 24 hours after antibiotic treatment of the spirochetal infections syphilis, Lyme disease, leptospirosis, and relapsing fever (RF), patients experience shaking chills, a rise in temperature, and intensification of skin rashes known as the Jarisch-Herxheimer reaction (JHR) with symptoms resolving a few hours later. Case reports indicate that the JHR can also include uterine contractions in pregnancy, worsening liver and renal function, acute respiratory distress syndrome, myocardial injury, hypotension, meningitis, alterations in consciousness, seizures, and strokes...
January 11, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28045216/zika-virus-and-pregnancy-an-overview
#15
Newton Sérgio de Carvalho, Beatriz Freitas de Carvalho, Bruna Dóris, Evellyn Silverio Biscaia, Cyllian Arias Fugaça, Lúcia de Noronha
In May 2015, the first episodes of Zika virus infection of the Latin America were confirmed in Brazil, where currently 196 976 cases were reported. The main route of transmission occurs by Aedes mosquitoes, and the most common symptoms are maculopapular rash, fever, conjunctivitis, polyarthralgia, and periarticular edema. However, the infection is asymptomatic in 80% of the cases. The congenital infection is characterized when the transmission to the fetus occurs during pregnancy, but the mechanisms of how the virus infects the placenta remain unclear...
February 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28033275/pregnancy-complicated-with-agranulocytosis
#16
Hai Wang, Jiang-Li Sun, Zheng-Liang Zhang, Hong-Hong Pei
RATIONALE: Pregnancy is a complicated physiological process. Physiological leukocytosis often takes place and it is primarily related to the increased circulation of neutrophils, especially during the last trimester of pregnancy. Noncongenital agranulocytosis during pregnancy is rare and reported only occasionally, while in most of the cases, the agranulocytosis has already occurred prior to pregnancy or induced by identified factors such as antibiotics, antithyroid agents, or cytotoxic agents...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28006998/supraventricular-tachycardia-during-the-first-year-of-life-is-subclinical-inflammation-the-trigger
#17
Pier Paolo Bassareo, Vassilios Fanos, Mario Pala, Luca Antonucci, Paola Neroni, Roberto Antonucci, Guseppe Mercuro
BACKGROUND: Neutrophil/lymphocyte ratio (NLR) and red cell distribution width (RDW) may be associated with the onset of arrhythmias in adults, thus underlining a possible inflammatory etiology. Paroxysmal supraventricular tachycardia (SVT) is the most frequent pathological tachycardia in childhood. AIM: To verify NLR and RDW levels in a group of children (<1 year) affected by SVT with a structurally normal heart and without fever or inflammatory diseases; to compare NLR and RDW before and after SVT resolution, to verify whether the latter was related with the reduction in inflammatory state; to identify - in SVT subtypes caused by a reentry mechanism - an NLR and RDW cutoff point beyond which adenosine was ineffective in preventing SVT recurrence...
January 12, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27981430/comparison-of-temporal-artery-thermometry-with-axillary-and-rectal-thermometry-in-full-term-neonates
#18
Ekta Goswami, Prerna Batra, Ritika Khurana, Pooja Dewan
OBJECTIVE: To assess the efficacy of temporal artery thermometer in febrile and hypothermic neonates in comparison to axillary thermometer. METHODS: It was a cross sectional observational study. Study participants included 210 neonates admitted in neonatal intensive care unit of a tertiary care teaching hospital, divided into three groups of 70 each, namely normothermic, febrile and hypothermic. Temperatures were measured using temporal artery, axillary and rectal thermometers in each patient...
December 16, 2016: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/27974123/-cpt2-gene-mutation-analysis-and-prenatal-diagnosis-in-a-family-with-carnitine-palmitoyltransferase-ii-deficiency
#19
Jian-Qiang Tan, Da-Yu Chen, Wu-Gao Li, Zhe-Tao Li, Ji-Wei Huang, Ti-Zhen Yan, Ren Cai
This study aimed to identify the type of carnitine palmitoyltransferase 2 (CPT2) gene mutation in the child with carnitine palmitoyltransferase II (CPT II) deficiency and her parents and to provide the genetic counseling and prenatal diagnosis for the family members. As the proband, a 3-month-old female baby was admitted to the hospital due to fever which had lasted for 8 hours. Tandem mass spectrometric analysis for blood showed an elevated plasma level of acylcarnitine, which suggested CPT II deficiency. The genomic DNA was extracted from peripheral blood of the patient and her parents...
December 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/27869982/characteristics-of-the-first-cases-of-microcephaly-possibly-related-to-zika-virus-reported-in-the-metropolitan-region-of-recife-pernambuco-state-brazil
#20
Alexander Vargas, Eduardo Saad, George Santiago Dimech, Roselene Hans Santos, Maria Auxiliadora Vieira Caldas Sivini, Luciana Carolina Albuquerque, Patricia Michelly Santos Lima, Idalacy de Carvalho Barreto, Michelly Evangelista de Andrade, Nathalie Mendes Estima, Patrícia Ismael de Carvalho, Rayane Souza de Andrade Azevedo, Rita de Cássia de Oliveira Vasconcelos, Romildo Siqueira Assunção, Lívia Carla Vinhal Frutuoso, Greice Madeleine Ikeda do Carmo, Priscila Bochi de Souza, Marcelo Yoshito Wada, Wanderson Kleber de Oliveira, Cláudio Maierovitch Pessanha Henriques, Jadher Percio
OBJECTIVE: to describe the first cases of microcephaly possibly related to Zika virus in live born babies reported in the Metropolitan Region of Recife, Pernambuco State, Brazil. METHODS: this was a descriptive case series study (cases reported between August 1st and October 31st 2015), using medical record data and data from a questionnaire answered by the mothers of the babies. RESULTS: 40 microcephaly cases were confirmed, distributed in eight municipalities within the Metropolitan Region, with Recife itself having the highest concentration of cases (n=12); median head circumference was 29 cm, median chest girth was 31 cm and median weight was 2,628 grams; 21/25 cases had brain calcification, ventriculomegaly or lissencephaly; 27 of the 40 mothers reported rash during pregnancy, 20 in the first trimester and 7 in the second trimester, as well as itching, headache, myalgia and absence of fever...
October 2016: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
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