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Hemophagocytic lymphohystiocytosis

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https://www.readbyqxmd.com/read/27326813/hematopoietic-stem-cell-transplantation-in-a-patient-with-icf2-syndrome-presenting-with-ebv-induced-hemophagocytic-lymphohystiocytosis
#1
Esther Harnisch, Emilie P Buddingh, Peter E Thijssen, Alice S Brooks, Gertjan J Driessen, Rogier Kersseboom, Arjan C Lankester
No abstract text is available yet for this article.
July 2016: Transplantation
https://www.readbyqxmd.com/read/25145768/visceral-leishmaniasis-associated-hemophagocytic-lymphohistiocytosis-in-a-traveler-returning-from-a-pilgrimage-to-the-camino-de-santiago
#2
Emily R Watkins, Sriram Shamasunder, Thomas Cascino, Kristie L White, Shereen Katrak, Caryn Bern, Brian S Schwartz
We report the case of a 73-year-old American traveler who presented with 3 weeks of fatigue, fevers, chills, and pancytopenia. Clinical and laboratory findings were consistent with hemophagocytic lymphohystiocytosis (HLH) and bone marrow biopsy revealed amastigotes consistent with visceral leishmaniasis. The range of endemic visceral leishmaniasis transmission now extends into northern Spain and travelers to this region should use personal protective measures against sand fly exposure.
November 2014: Journal of Travel Medicine
https://www.readbyqxmd.com/read/24720151/-from-unexplained-fever-to-visceral-leishmaniasis-a-case-report
#3
Ivan Marković, Ana Gudelj-Gracanin, Melanie-Ivana Culo, Tajana Stoos-Veić, Ninoslava Vicković, Bosko Desnica, Jadranka Morović-Vergles
Visceral leishmaniasis or kala-azar is a systemic infectious vector-borne disease caused by protozoa Leishmania donovani and Leishmania infantum that are transmitted to mammalian hosts by sand flies. It occurrs sporadically in endemic areas, including Mediterranean basin. Southern coastal territories of Croatia have been recognized as the foci of the disease. Dogs are the main reservoir of human infection. Clinical features include prolonged fever, malaise, hepatosplenomegaly, pancytopenia and inversion of albumin-globulin ratio...
January 2014: Lijec̆nic̆ki Vjesnik
https://www.readbyqxmd.com/read/22437823/analyses-of-the-prf1-gene-in-individuals-with-hemophagocytic-lymphohystiocytosis-reveal-the-common-haplotype-r54c-a91v-in-colombian-unrelated-families-associated-with-late-onset-disease
#4
Isaura P Sánchez, Lucía C Leal-Esteban, Jesús A Álvarez-Álvarez, Camilo A Pérez-Romero, Julio C Orrego, Malyive L Serna, Yadira Coll, Yolanda Caicedo, Edwin Pardo-Díaz, Jacques Zimmer, Jack J Bleesing, José L Franco, Claudia M Trujillo-Vargas
Familial hemophagocytic lymphohistiocytosis (FHL), is a rare autosomal recessive disorder characterized by an impairment of cytotoxic cells and uncontrolled activation of macrophages. This study presents the first description of four patients with FHL type 2 in Latin America. Patient 1 fulfilled the disease diagnostic criteria since 2 months of age, whereas patients 2, 3 and 4 exhibited the typical manifestations of the disease only later in their childhood. The PRF1 genetic analysis in these patients revealed two previously reported mutations: L17fsx50 and R54C...
August 2012: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/20432763/neonatal-hemophagocytic-lymphohistiocytosis-case-report
#5
Jelena Roganović, Barbara Kvenić, Nives Jonjić, Irena Seili-Bekafigo, Ika Kardum-Skelin
Hemophagocytic lymphohystiocytosis (HLH) represents a severe hyperinflammatory condition with the cardinal symptoms prolonged fever, hepatosplenomegaly, and cytopenias. The most prominent histopathological feature of HLH is an accumulation of activated T lymphocytes and macrophages predominantly in lymphoid tissues. Although it can occur in all age groups, neonatal-onset HLH is very rare. We report on a case of HLH presenting with anemia and respiratory distress at birth. Several weeks prior to diagnosis the symptoms were attributed to a systemic infection...
March 2010: Collegium Antropologicum
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