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Advanced imaging technique

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https://www.readbyqxmd.com/read/29029290/nmda-receptor-mediated-ca2-influx-in-the-absence-of-mg2-block-disrupts-rest-activity-rhythms-in-drosophila
#1
Qian Song, Ge Feng, Jiaxing Zhang, Xuechun Xia, Min Ji, Lei Lv, Yong Ping
Introduction: The correlated activation of pre- and postsynaptic neurons is essential for the NMDA receptor-mediated Ca2+ influx by removing Mg2+ from block site and NMDA receptors have been implicated in phase resetting of circadian clocks. So we assessed rest:activity rhythms in Mg2+ block defective animals. Methods: Using Drosophila locomotor monitoring system, we checked circadian rest:activity rhythms of different mutants under constant darkness (DD) and light:dark (LD) conditions...
October 3, 2017: Sleep
https://www.readbyqxmd.com/read/29028297/spectroscopic-imaging-at-the-nanoscale-technologies-and-recent-applications
#2
Lifu Xiao, Zachary D Schultz
Advances in technology now enable infrared and Raman vibrational spectroscopic imaging with resolution on the molecular scale. A number of techniques have emerged that provide spectroscopic imaging with nanometer scale resolution including: tip-enhanced Raman scattering (TERS), infrared scattering-type scanning near-field optical microscopy (IR s-SNOM), atomic force microscopy infrared (AFM-IR), and photon induced force microscopy (PiFM). In this article we profile recent advances in nanoscale spectroscopic imaging, discussing differences in the methods, highlighting recent technical advances, and reporting applications with each approach...
October 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29026940/advanced-bioanalytics-for-precision-medicine
#3
Aldo Roda, Elisa Michelini, Cristiana Caliceti, Massimo Guardigli, Mara Mirasoli, Patrizia Simoni
Precision medicine is a new paradigm that combines diagnostic, imaging, and analytical tools to produce accurate diagnoses and therapeutic interventions tailored to the individual patient. This approach stands in contrast to the traditional "one size fits all" concept, according to which researchers develop disease treatments and preventions for an "average" patient without considering individual differences. The "one size fits all" concept has led to many ineffective or inappropriate treatments, especially for pathologies such as Alzheimer's disease and cancer...
October 12, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29026367/mitochondrial-encephalomyopathy-with-lactic-acidosis-and-stroke-like-episodes-melas-syndrome
#4
Caitlin Henry, Neema Patel, William Shaffer, Lillian Murphy, Joe Park, Bradley Spieler
BACKGROUND: Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) syndrome is a rare inherited disorder that results in waxing and waning nervous system and muscle dysfunction. MELAS syndrome may overlap with other neurologic disorders but shows distinctive imaging features. CASE REPORT: We present the case of a 28-year-old female with atypical stroke-like symptoms, a strong family history of stroke-like symptoms, and a relapsing-remitting course for several years...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29025192/erratum-advanced-mri-techniques-for-muscle-imaging
#5
Vivek Kalia, Doris G Leung, Darryl B Sneag, Filippo Del Grande, John A Carrino
No abstract text is available yet for this article.
November 2017: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/29025029/ct-coronary-imaging-a-fast-evolving-world
#6
Prabhakar Rajiah, Suhny Abbara
Computed tomography (CT) has become an important modality in the evaluation of coronary artery disease (CAD). The tremendous technological advances in CT in the last two decades has made it possible to obtain high quality images of coronary arteries with high spatial and temporal resolutions. Multiple trials have confirmed the accuracy of CT compared to invasive catheter angiography. CT is also able to evaluate beyond the lumen in characterizing and quantifying atherosclerotic plaques, including evaluation of high risk features...
September 4, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29024679/short-range-connections-in-the-developmental-connectome-during-typical-and-atypical-brain-maturation
#7
REVIEW
Minhui Ouyang, Huiying Kang, John A Detre, Timothy P L Roberts, Hao Huang
The human brain is remarkably complex with connectivity constituting its basic organizing principle. Although long-range connectivity has been focused on in most research, short-range connectivity is characterized by unique and spatiotemporally heterogeneous dynamics from infancy to adulthood. Alterations in the maturational dynamics of short-range connectivity has been associated with neuropsychiatric disorders, such as autism and schizophrenia. Recent advances in neuroimaging techniques, especially diffusion magnetic resonance imaging (dMRI), resting-state functional MRI (rs-fMRI), electroencephalography (EEG) and magnetoencephalography (MEG), have made quantification of short-range connectivity possible in pediatric populations...
October 9, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29024292/hepatic-cystic-echinococcosis-in-australia-an-update-on-diagnosis-and-management
#8
REVIEW
Ben Keong, Bruce Wilkie, Tom Sutherland, Adrian Fox
BACKGROUND: Echinococcosis is an uncommonly encountered zoonotic disease caused by the taeniid Echinococcus. The only endemic species in Australia, Echinococcus granulosus, forms cysts in the liver in 70% of cases. The aim of this study was to review the literature to provide an evidence-based narrative update on the diagnosis and management of hepatic cystic echinococcosis in Australia. METHODS: We reviewed the literature, utilizing multiple research databases and citation tracking...
October 11, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29024010/imaging-behind-occluded-areas-with-an-iatrogenic-perforated-balloon-a-safe-practical-and-simple-new-method-of-visualizing-the-distal-lumen-in-total-occlusion
#9
Yakup Balaban, Osman Bektaş, Adil Bayramoğlu, Hasan A Gümrükçüoğlu, Ali H Kayışoğlu
OBJECTIVE: In the present study, we investigated the effectiveness and reliability of a new method that reveals whether guidewire advanced distal to the lesion is in the lumen in patients with acute (ATO) or chronic coronary total occlusion (CTO). METHODS: Forty-one patients with symptomatic ATO and 22 patients with CTO who were admitted into our catheterization laboratory between January 2016 and March 2017 were included. In patients in whom antegrade filling could not be demonstrated after passing 0...
October 10, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/29023881/review-article-the-role-of-the-microcirculation-in-liver-cirrhosis
#10
REVIEW
T Davies, S Wythe, J O'Beirne, D Martin, E Gilbert-Kawai
BACKGROUND: Intrahepatic microvascular derangements and microcirculatory dysfunction are key in the development of liver cirrhosis and its associated complications. While much has been documented relating to cirrhosis and the dysfunction of the microcirculation in the liver parenchyma, far less is known about the state of the extrahepatic microcirculation and the role this may have in the pathogenesis of multiple organ failure in end stage liver cirrhosis. AIM: To provide an update on the role of the microcirculation in the pathophysiology of cirrhosis and its associated complications and briefly discuss some of the imaging techniques which may be used to directly investigate the microcirculation...
November 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29022777/feasibility-of-modified-dixon-mri-techniques-for-hepatic-fat-quantification-in-hepatic-disorders-validation-with-mrs-and-histology
#11
Bo-Kyeong Kang, Mimi Kim, Soon-Young Song, Dae Won Jun, Kiseok Jang
OBJECTIVE: To assess the feasibility of proton density fat fraction (PDFF) magnetic resonance imaging (MRI) for estimating hepatic fat fraction with magnetic resonance spectroscopy (MRS) and histology as references and to investigate intrahepatic fat distribution and variability. METHODS: Between November 2014 and September 2015, 85 adults (48 men, 47 women) who underwent MRI-PDFF (n=139), MRS-PDFF (n=49) and liver biopsy (n=29) were enrolled in this study. Data were compared using linear regression...
October 12, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29022018/versatile-design-and-synthesis-of-nano-barcodes
#12
REVIEW
Swati Shikha, Thoriq Salafi, Jinting Cheng, Yong Zhang
Encoded nano-structures/particles have been used for barcoding and are in great demand for the simultaneous analysis of multiple targets. Due to their nanoscale dimension(s), nano-barcodes have been implemented favourably for bioimaging, in addition to their security and multiplex bioassay application. In designing nano-barcodes for a specific application, encoding techniques, synthesis strategies, and decoding techniques need to be considered. The encoding techniques to generate unique multiple codes for nano-barcodes are based on certain encoding elements including optical (fluorescent and non-fluorescent), graphical, magnetic, and phase change properties of nanoparticles or their different shapes and sizes...
October 12, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/29021882/primary-osteosarcoma-of-the-distal-fibula-treated-with-distal-fibulectomy-with-a-five-year-follow-up-a-case-report
#13
I Saadon, B Amit, A Zolquarnian, F Muhamad
Musculoskeletal tumours of the lower limbs especially malignant tumours are not common. The fibula is the site of primary bone tumours as reported in 2.4% of lower limb tumours with the proximal third being more frequently involved than the distal segment. Osteosarcoma is the most common primary malignant bone tumour of nonhaematopoietic origin, with distal fibular involvement in 0.47% of patients. The advances in imaging techniques and neo-adjuvant chemotherapy have now made it possible to accurately define the extent of tumour and plan limb salvage with tumour resection...
July 2017: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/29021839/diffusion-tensor-imaging-for-multilevel-assessment-of-the-visual-pathway-possibilities-for-personalized-outcome-prediction-in-autoimmune-disorders-of-the-central-nervous-system
#14
REVIEW
Joseph Kuchling, Alexander U Brandt, Friedemann Paul, Michael Scheel
The afferent visual pathway represents the most frequently affected white matter pathway in multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD). Diffusion tensor imaging (DTI) can reveal microstructural or non-overt brain tissue damage and quantify pathological processes. DTI facilitates the reconstruction of major white matter fiber tracts allowing for the assessment of structure-function and damage-dysfunction relationships. In this review, we outline DTI studies investigating the afferent visual pathway in idiopathic optic neuritis (ON), NMOSD, and MS...
September 2017: EPMA Journal
https://www.readbyqxmd.com/read/29021301/recent-approaches-to-optimize-laboratory-assessment-of-antinuclear-antibodies
#15
Anne E Tebo
The presence of antinuclear antibodies (ANA) is a hallmark feature of a number of systemic autoimmune rheumatic diseases (SARD) and testing is usually performed as part of the initial diagnostic workup when suspicion of an underlying autoimmune disorder is high. The indirect immunofluorescence antibody (IFA) technique is the preferred method for detecting ANA as it demonstrates binding to specific intracellular structures within the cells resulting in a number of staining patterns that are usually categorized based on the cellular components recognized and the degree of binding reflected by the fluorescent intensity or titer...
October 11, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/29020422/a-modified-foveal-advancement-technique-in-the-treatment-of-persistent-large-macular-holes
#16
Gökhan Gurelik, Sabahattin Sul, Gaye Kılıç, Cemal Özsaygılı
BACKGROUND AND OBJECTIVE: To evaluate the outcomes of a new surgical technique on the closure of persistent large macular holes (MHs) PATIENTS AND METHODS:Data for 10 eyes of 10 patients who underwent surgical intervention for the treatment of large and persistent MHs were reviewed retrospectively. After entrance of the three-port transconjunctival 23-gauge sutureless vitrectomy instruments, a shallow perihole retinal detachment was formed by injecting a small amount of fluid with a 39-gauge /41-gauge subretinal cannula under the perihole (superior, temporal, and inferior sparing nasal bundle fibers) retina...
October 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29019936/image-based-analysis-to-dissect-vertical-distribution-and-horizontal-asymmetry-of-conspecific-root-system-interactions-in-response-to-planting-densities-nutrients-and-root-exudates-in-arabidopsis-thaliana
#17
Jane Geisler-Lee, Xian Liu, Wei Rang, Jayanthan Raveendiran, Marisa Blake Szubryt, David John Gibson, Matt Geisler, Qiang Cheng
Intraspecific competition is an important plant interaction that has been studied extensively aboveground, but less so belowground, due to the difficulties in accessing the root system experimentally. Recent in vivo and in situ automatic imaging advances help understand root system architecture. In this study, a portable imaging platform and a scalable transplant technique were applied to test intraspecific competition in Arabidopsis thaliana. A single green fluorescent protein labeled plant was placed in the center of a grid of different planting densities of neighboring unlabeled plants or empty spaces, into which different treatments were made to the media...
October 11, 2017: Plants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29019744/pediatric-liver-transplant-techniques-and-complications
#18
Natally Horvat, Antonio Sergio Zafred Marcelino, Joao Vicente Horvat, Tássia Regina Yamanari, Jose de Arimateia Batista Araújo-Filho, Pedro Panizza, Joao Seda-Neto, Eduardo Antunes da Fonseca, Francisco Cesar Carnevale, Luciana Mendes de Oliveira Cerri, Paulo Chapchap, Giovanni Guido Cerri
Liver transplant is considered to be the last-resort treatment approach for pediatric patients with end-stage liver disease. Despite the remarkable advance in survival rates, liver transplant remains an intricate surgery with significant morbidity and mortality. Early diagnosis of complications is crucial for patient survival but is challenging given the lack of specificity in clinical presentation. Knowledge of the liver and vascular anatomy of the donor and the recipient or recipients before surgery is also important to avoid complications...
October 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29019460/auditory-hallucinations-as-translational-psychiatry-evidence-from-magnetic-resonance-imaging
#19
Kenneth Hugdahl
In this invited review article I present a translational perspective and overview of our research on auditory hallucinations in schizophrenia at the University of Bergen, Norway with a focus on the neuronal mechanisms underlying the phenomenology of experiencing "hearing voices". An auditory verbal hallucination, i.e. "hearing a voice", is defined as a sensory experience in the absence of a corresponding external sensory source that could explain the phenomenological experience. I suggest a general frame or scheme for the study of auditory verbal hallucinations which is called Levels of Explanation (LoE)...
October 11, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/29017290/role-of-advanced-endoscopic-imaging-techniques-in-the-management-of-inflammatory-bowel-disease
#20
REVIEW
Eun Soo Kim
Endoscopy plays a crucial role in the management of inflammatory bowel disease (IBD) in terms of diagnosis, monitoring of mucosal status, and surveillance of colitis-associated neoplasia. Mucosal healing evaluated by endoscopy has been recognized as the target of treatment in the era of powerful biologics therapy. The optimal modality for identifying dysplasia in IBD has yet to be well defined. Increasing progress has recently been made in endoscopic technologies to more accurately assess mucosal inflammation and more effectively detect dysplasia...
September 2017: Clinical Endoscopy
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