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https://www.readbyqxmd.com/read/29447789/comprehensive-electrocardiogram-to-device-time-for-primary-percutaneous-coronary-intervention-in-st-segment-elevation-myocardial-infarction-a-report-from-the-american-heart-association-mission-lifeline-program
#1
Jay S Shavadia, William French, Anne S Hellkamp, Laine Thomas, Eric R Bates, Steven V Manoukian, Michael C Kontos, Robert Suter, Timothy D Henry, Harold L Dauerman, Matthew T Roe
BACKGROUND: Assessing hospital-related network-level primary percutaneous coronary intervention (PCI) performance for ST-segment elevation myocardial infarction (STEMI) is challenging due to differential time-to-treatment metrics based on location of diagnostic electrocardiogram (ECG) for STEMI. METHODS: STEMI patients undergoing primary PCI at 588 PCI-capable hospitals in AHA Mission: Lifeline (2008-2013) were categorized by initial STEMI identification location: PCI-capable hospitals (Group 1); pre-hospital setting (Group 2); and non-PCI-capable hospitals (Group 3)...
March 2018: American Heart Journal
https://www.readbyqxmd.com/read/29446712/measures-of-sympathetic-and-parasympathetic-autonomic-outflow-from-heartbeat-dynamics
#2
Gaetano Valenza, Luca Citi, J Phillip Saul, Riccardo Barbieri
Reliable and effective non-invasive measures of sympathetic and parasympathetic peripheral outflow are of crucial importance in cardiovascular physiology. Although many techniques have been proposed to take up this long-lasting challenge, none has proposed a satisfying discrimination of the dynamics of the two separate branches. Spectral analysis of heart rate variability is the most currently used technique for such assessment. Despite its widespread use, it has been demonstrated that the subdivision in the low frequency (LF) and high frequency (HF) bands does not fully reflect separate influences of the sympathetic and parasympathetic branches, respectively, mainly due to their simultaneous action in the LF...
February 15, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29438471/severity-of-chagasic-cardiomyopathy-is-associated-with-response-to-a-novel-rapid-diagnostic-test-for-trypanosoma-cruzi-tcii-v-vi
#3
Tapan Bhattacharyya, Louisa A Messenger, Caryn Bern, Pascal Mertens, Quentin Gilleman, Nicolas Zeippen, Bruno C Bremer Hinckel, Niamh Murphy, Robert H Gilman, Michael A Miles
Background: Trypanosoma cruzi causes Chagas disease in the Americas. Outcome of infection ranges from lifelong asymptomatic status to severe disease. Understanding how history of T. cruzi lineage (TcI-TcVI) infection relates to clinical prognosis is challenging. We previously described peptide-based lineage-specific ELISA with Trypomastigote Small Surface Antigen (TSSA). Methods: A novel rapid diagnostic test (Chagas Sero K-SeT) incorporating a peptide corresponding to the TSSA-II/V/VI common epitope was developed, and validated by comparison with ELISA...
February 9, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29427251/heart-brain-interactions-in-the-mr-environment-characterization-of-the-ballistocardiogram-in-eeg-signals-collected-during-simultaneous-fmri
#4
Marco Marino, Quanying Liu, Mariangela Del Castello, Cristiana Corsi, Nicole Wenderoth, Dante Mantini
The ballistocardiographic (BCG) artifact is linked to cardiac activity and occurs in electroencephalographic (EEG) recordings acquired inside the magnetic resonance (MR) environment. Its variability in terms of amplitude, waveform shape and spatial distribution over subject's scalp makes its attenuation a challenging task. In this study, we aimed to provide a detailed characterization of the BCG properties, including its temporal dependency on cardiac events and its spatio-temporal dynamics. To this end, we used high-density EEG data acquired during simultaneous functional MR imaging in six healthy volunteers...
February 9, 2018: Brain Topography
https://www.readbyqxmd.com/read/29425320/treatment-for-uncomplicated-plasmodium-falciparum-malaria-in-french-soldiers-deployed-in-sub-saharan-africa-gaps-between-policy-and-field-practice
#5
Anne Perisse, Guillaume Velut, Emilie Javelle, Gwion Loarer, Remy Michel, F Simon
Background: Malaria prevention and treatment are big challenges for the French forces deployed in sub-Saharan Africa. Since December 2013, 1,800 French soldiers have been deployed at any one time in the Central African Republic in the framework of "Operation Sangaris" and European Union Force (EUFOR). Over the 2014-2015 period, about 500 cases of malaria were notified in these troops during the operation or after their return (annual incidence: 13.4 p.100 person-year). The recommendation to use dihydroartemisinin-piperaquine (DHA-PQ) as the first-line treatment for French soldiers suffering from uncomplicated Plasmodium falciparum malaria in endemic areas is not always followed in practice in the field by French military general practitioners (GPs)...
February 7, 2018: Military Medicine
https://www.readbyqxmd.com/read/29425111/the-safety-of-lipistart-a-medium-chain-triglyceride-based-formula-in-the-dietary-treatment-of-long-chain-fatty-acid-disorders-a-phase-i-study
#6
Anita MacDonald, Rachel Webster, Matthew Whitlock, Adam Gerrard, Anne Daly, Mary Anne Preece, Sharon Evans, Catherine Ashmore, Anupam Chakrapani, Suresh Vijay, Saikat Santra
BACKGROUND: Children with long-chain fatty acid β-oxidation disorders (LCFAOD) presenting with clinical symptoms are treated with a specialist infant formula, with medium chain triglyceride (MCT) mainly replacing long chain triglyceride (LCT). It is essential that the safety and efficacy of any new specialist formula designed for LCFAOD be tested in infants and children. METHODS: In an open-label, 21-day, phase I trial, we studied the safety of a new MCT-based formula (feed 1) in six well-controlled children (three male), aged 7-13 years (median 9 years) with LCFAOD (very long chain acyl CoA dehydrogenase deficiency [VLCADD], n=2; long chain 3-hydroxyacyl CoA dehydrogenase deficiency [LCHADD], n=2; carnitine acyl carnitine translocase deficiency [CACTD], n=2)...
February 9, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29409092/-gallop-in-the-routineergometrie-only-chore-or-diagnostic-challenge
#7
Stephan Knöchner, K Kronberg, U Schumann
ANAMNESIS:  A 47-year-old recreational sportsman showed in a routine ergometry polymorphic ventricular extrasystoles with good physical performance. INVESTIGATIONS:  In resting ECG impressed ventricular extrasystoles (VES) predominantly right-hand-block-like with superior axis, a long-term ECG yielded up to 100 VES per hour. Echocardiographically imposing 4 - 5 trabeculae, feathered, reticular structures apically in the left and lower in the right ventricle...
February 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29406398/resuscitation-room-management-of-critically-ill-nontraumatic-patients-in-a-german-emergency-department-observe-study
#8
Michael Bernhard, Stephanie Döll, Thomas Hartwig, Alexandra Ramshorn-Zimmer, Maryam Yahiaoui-Doktor, Lorenz Weidhase, Sirak Petros, André Gries
BACKGROUND: Management of critically ill nontrauma (CINT) patients in the resuscitation room (RR) of the emergency department (ED) is very challenging. Detailed data describing the characteristics and management of this population are lacking. This observational study describes the epidemiology, management and outcome in CINT ED patients in the RR. PATIENTS AND METHODS: From September 2014 to August 2015, data were collected prospectively on adult CINT patients admitted to the RR of a single German University ED...
February 5, 2018: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
https://www.readbyqxmd.com/read/29404363/electrocardiographic-artifact-potentially-misleading-to-the-wrong-management
#9
Srishti Sareen, Mannu Nayyar, Brian Wheeler, Michelle Skelton, Rami N Khouzam
Atrial flutter (AF) is the second most common supraventricular tachyarrhythmia following atrial fibrillation. We present an interesting case of a diagnostic challenge manifested as an electrocardiogram (ECG) recording mimicking AF in a patient with Parkinson's disease (PD). A 72-year-old African-American female with history of PD presented to our Emergency Department with a one day history of chest pain. Her vital signs were within normal limits. Physical exam was remarkable for bilateral resting hand tremors at a frequency of 6-8 hertz and mild cogwheel rigidity in both upper extremities...
January 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29399918/ecg-electrode-reversals-an-opportunity-to-learn-from-mistakes
#10
Scott Sakaguchi, Jeremy Sandberg, David G Benditt
An ECG with an "odd" appearance may raise the suspicion that ECG recording electrodes may have been reversed. Odd appearances include unexpected Q-waves or R-waves, markedly isoelectric leads, and abrupt changes from previous ECGs. A few examples of ECG electrode reversal provide the opportunity to review some fundamental principles of ECG recording. Some ECG electrode reversals will invert the QRS complex recorded in a lead. Other ECG leads may be affected in a manner that initially may seem unexpected. These patterns may be understood upon reviewing the genesis of the "unipolar" leads, particularly the "augmented" leads...
February 5, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29392549/acute-fissuration-of-a-giant-splenic-artery-aneurysm-detected-by-point-of-care-ultrasound-case-report
#11
Philippe Le Conte, David Trewick, Philippe Pes, Eric Frampas, Eric Batard
BACKGROUND: Epigastric pain is frequent in Emergency Medicine and remains a challenging situation. Besides benign etiologies such as gastritis or uncomplicated cholelithiasis, it could reveal myocardial infarction or vascular disease. Point-of-care ultrasound (POCUS) could be performed in such situation. CASE PRESENTATION: A healthy 66-year-old man with no previous medical history was admitted to the Emergency Department for a rapid onset epigastric pain. He reported taking non-steroidal anti-inflammatories for 1 week prior to admission...
February 1, 2018: Critical Ultrasound Journal
https://www.readbyqxmd.com/read/29387326/performance-of-electrophysiologic-study-in-an-asymptomatic-patient-with-type-2-intermittent-brugada-syndrome-to-do-or-not-to-do
#12
Kaveh Hosseini, Mansour Jahangiri, Ali Vasheghani Farahani
Background: Brugada syndrome (BrS) is an inherited channelopathy, which is associated with sudden cardiac death due to rapid polymorphic VT or VF. There is no definite consensus regarding the management of asymptomatic patients. Some experts advocate close follow-up; others propose the programmed stimulation for risk stratification. We aimed to evaluate the benefit of complete atrial and ventricular stimulation in patients with BrS and palpitation. Case Presentation: A 30-year-old man was admitted to our hospital because of a family history of sudden cardiac death (SCD) at age less than 45 years...
2018: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/29382555/reliability-and-robustness-of-feedback-evoked-brain-heart-coupling-after-placebo-dopamine-and-noradrenaline-challenge
#13
Maximilian Lueckel, Christian Panitz, Urs M Nater, Erik M Mueller
External and internal performance feedback triggers not only neural but also cardiac modulations, suggesting communication between brain and heart during feedback processing. Using Cardio-Electroencephalographic Covariance Tracing (CECT), it has accordingly been shown that feedback-evoked centromedial single-trial EEG at the P300 latency intraindividually predicts subsequent changes in heart period - the so called N300H phenomenon. While previous findings suggest that the N300H depends on serotonin, its relationship to central dopamine and noradrenaline is currently unknown...
January 27, 2018: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29358581/simple-and-cost-effective-method-of-highly-conductive-and-elastic-carbon-nanotube-polydimethylsiloxane-composite-for-wearable-electronics
#14
Jeong Hun Kim, Ji-Young Hwang, Ha Ryeon Hwang, Han Seop Kim, Joong Hoon Lee, Jae-Won Seo, Ueon Sang Shin, Sang-Hoon Lee
The development of various flexible and stretchable materials has attracted interest for promising applications in biomedical engineering and electronics industries. This interest in wearable electronics, stretchable circuits, and flexible displays has created a demand for stable, easily manufactured, and cheap materials. However, the construction of flexible and elastic electronics, on which commercial electronic components can be mounted through simple and cost-effective processing, remains challenging. We have developed a nanocomposite of carbon nanotubes (CNTs) and polydimethylsiloxane (PDMS) elastomer...
January 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29358103/application-of-stacked-convolutional-and-long-short-term-memory-network-for-accurate-identification-of-cad-ecg-signals
#15
Jen Hong Tan, Yuki Hagiwara, Winnie Pang, Ivy Lim, Shu Lih Oh, Muhammad Adam, Ru San Tan, Ming Chen, U Rajendra Acharya
Coronary artery disease (CAD) is the most common cause of heart disease globally. This is because there is no symptom exhibited in its initial phase until the disease progresses to an advanced stage. The electrocardiogram (ECG) is a widely accessible diagnostic tool to diagnose CAD that captures abnormal activity of the heart. However, it lacks diagnostic sensitivity. One reason is that, it is very challenging to visually interpret the ECG signal due to its very low amplitude. Hence, identification of abnormal ECG morphology by clinicians may be prone to error...
January 2, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29356998/real-time-closed-loop-diastolic-interval-control-prevents-cardiac-alternans-in-isolated-whole-rabbit-hearts
#16
Kanchan Kulkarni, Steven W Lee, Ryan Kluck, Elena G Tolkacheva
Cardiac alternans, a beat-to-beat alternation in action potential duration (APD), can lead to fatal arrhythmias. During periodic pacing, changes in diastolic interval (DI) depend on subsequent changes in APD, thus enhancing cardiac instabilities through a 'feedback' mechanism. Recently, an anti-arrhythmic Constant DI pacing protocol was proposed and shown to be effective in suppressing alternans in 0D and 1D in silico studies. However, previous experimental validation of Constant DI pacing in the heart has been unsuccessful due to the spatio-temporal complexity of 2D cardiac tissue and the technical challenges in its real-time implementation...
January 22, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29322351/from-pacemaker-to-wearable-techniques-for-ecg-detection-systems
#17
REVIEW
Ashish Kumar, Rama Komaragiri, Manjeet Kumar
With the alarming rise in the deaths due to cardiovascular diseases (CVD), present medical research scenario places notable importance on techniques and methods to detect CVDs. As adduced by world health organization, technological proceeds in the field of cardiac function assessment have become the nucleus and heart of all leading research studies in CVDs in which electrocardiogram (ECG) analysis is the most functional and convenient tool used to test the range of heart-related irregularities. Most of the approaches present in the literature of ECG signal analysis consider noise removal, rhythm-based analysis, and heartbeat detection to improve the performance of a cardiac pacemaker...
January 11, 2018: Journal of Medical Systems
https://www.readbyqxmd.com/read/29321268/computational-techniques-for-ecg-analysis-and-interpretation-in-light-of-their-contribution-to-medical-advances
#18
REVIEW
Aurore Lyon, Ana Mincholé, Juan Pablo Martínez, Pablo Laguna, Blanca Rodriguez
Widely developed for clinical screening, electrocardiogram (ECG) recordings capture the cardiac electrical activity from the body surface. ECG analysis can therefore be a crucial first step to help diagnose, understand and predict cardiovascular disorders responsible for 30% of deaths worldwide. Computational techniques, and more specifically machine learning techniques and computational modelling are powerful tools for classification, clustering and simulation, and they have recently been applied to address the analysis of medical data, especially ECG data...
January 2018: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29313142/opportunities-and-challenges-of-large-scale-screening-for-atrial-fibrillation
#19
REVIEW
Matthias Daniel Zink, Nikolaus Marx, Harry J G M Crijns, Ulrich Schotten
Atrial fibrillation (AF) is a common arrhythmia and is highly associated with stroke and cardiovascular morbidity. As many AF episodes remain subclinical (SCAF), large-scale AF screening is considered a desirable approach for the treatment and prevention of cardioembolic stroke. Newly available single-lead ECG devices have provided promising results in the diagnosis of SCAF and treatment by nonvitamin K antagonist drugs appears to be safe and effective. Nevertheless, a further gain in knowledge is needed to clarify the different types of AF...
January 8, 2018: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/29291535/detecting-atrial-fibrillation-by-deep-convolutional-neural-networks
#20
Yong Xia, Naren Wulan, Kuanquan Wang, Henggui Zhang
BACKGROUND: Atrial fibrillation (AF) is the most common cardiac arrhythmia. The incidence of AF increases with age, causing high risks of stroke and increased morbidity and mortality. Efficient and accurate diagnosis of AF based on the ECG is valuable in clinical settings and remains challenging. In this paper, we proposed a novel method with high reliability and accuracy for AF detection via deep learning. METHOD: The short-term Fourier transform (STFT) and stationary wavelet transform (SWT) were used to analyze ECG segments to obtain two-dimensional (2-D) matrix input suitable for deep convolutional neural networks...
December 15, 2017: Computers in Biology and Medicine
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