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https://www.readbyqxmd.com/read/29038102/st-elevation-magnitude-correlates-with-right-ventricular-outflow-tract-conduction-delay-in-type-i-brugada-ecg
#1
Kevin M W Leong, Fu Siong Ng, Cheng Yao, Caroline Roney, Patricia Taraborrelli, Nicholas W F Linton, Zachary I Whinnett, David C Lefroy, D Wyn Davies, Phang Boon Lim, Sian E Harding, Nicholas S Peters, Prapa Kanagaratnam, Amanda M Varnava
BACKGROUND: The substrate location and underlying electrophysiological mechanisms that contribute to the characteristic ECG pattern of Brugada syndrome (BrS) are still debated. Using noninvasive electrocardiographical imaging, we studied whole heart conduction and repolarization patterns during ajmaline challenge in BrS individuals. METHODS AND RESULTS: A total of 13 participants (mean age, 44±12 years; 8 men), 11 concealed patients with type I BrS and 2 healthy controls, underwent an ajmaline infusion with electrocardiographical imaging and ECG recordings...
October 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29016773/multichannel-electrocardiogram-diagnostics-for-the-diagnosis-of-arrhythmogenic-right-ventricular-dysplasia
#2
Ricards Marcinkevics, James O'Neill, Hannah Law, Eleftheria Pervolaraki, Andrew Hogarth, Craig Russell, Berthold Stegemann, Arun V Holden, Muzahir H Tayebjee
Aims: The identification of arrhythmogenic right ventricular dysplasia (ARVD) from 12-channel standard electrocardiogram (ECG) is challenging. High density ECG data may identify lead locations and criteria with a higher sensitivity. Methods and results: Eighty-channel ECG recording from patients diagnosed with ARVD and controls were quantified by magnitude and integral measures of QRS and T waves and by a measure (the average silhouette width) of differences in the shapes of the normalized ECG cycles...
August 29, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28979516/myocardial-infarction-in-intensive-care-units-a-systematic-review-of-diagnosis-and-treatment
#3
REVIEW
Iain Carroll, Thomas Mount, Dougal Atkinson
INTRODUCTION: Patients in the intensive care unit are vulnerable to myocardial injury from a variety of causes, both ischaemic and non-ischaemic. It is challenging for ICU clinicians to apply the conventional guidance concerning diagnosis and treatment. We conducted this review to examine the evidence concerning diagnosis and treatment of myocardial infarction in the ICU. METHODS: A systematic review was performed to identify relevant studies. RESULTS: 19 studies concerning use of ECG, cardiac enzymes, echocardiography and angiography were identified...
November 2016: J Intensive Care Soc
https://www.readbyqxmd.com/read/28970037/a-novel-method-for-evaluating-regional-rv-function-in-the-adult-congenital-heart-with-low-dose-ct-and-squeez-processing
#4
Francisco J Contijoch, Daniel W Groves, Zhennong Chen, Marcus Y Chen, Elliot R McVeigh
BACKGROUND: Measuring local RV function in adult congenital heart disease (ACHD) with echocardiography or MRI is challenging because of the complex geometry and existing pacing devices. Visual assessment of ventricular function via low-dose cardiac CT has been recently performed. This pilot study assessed whether low-dose 4D cine CT combined with automatic measurement of regional shortening could quantify right-ventricular function in ACHD patients. METHODS: Seven patients with Tetralogy of Fallot either contraindicated for MRI or assessed for coronary artery disease and seven non-congenital patients were imaged with ECG-gated cardiac CT utilizing a 320-detector row scanner...
September 29, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28952588/a-proof-of-concept-study-simple-and-effective-detection-of-p-and-t-waves-in-arrhythmic-ecg-signals
#5
Mohamed Elgendi, Marianna Meo, Derek Abbott
A robust and numerically-efficient method based on two moving average filters, followed by a dynamic event-related threshold, has been developed to detect P and T waves in electrocardiogram (ECG) signals as a proof-of-concept. Detection of P and T waves is affected by the quality and abnormalities in ECG recordings; the proposed method can detect P and T waves simultaneously through a unique algorithm despite these challenges. The algorithm was tested on arrhythmic ECG signals extracted from the MIT-BIH arrhythmia database with 21,702 beats...
October 17, 2016: Bioengineering
https://www.readbyqxmd.com/read/28949414/age-dependent-electrocardiographic-changes-in-pgc-1%C3%AE-deficient-murine-hearts
#6
Shiraz Ahmad, Haseeb Valli, Samantha C Salvage, Andrew A Grace, Kamalan Jeevaratnam, Christopher L-H Huang
Increasing evidence implicates chronic energetic dysfunction in human cardiac arrhythmias. Mitochondrial impairment through Pgc-1β knockout is known to produce a murine arrhythmic phenotype. However, the cumulative effect of this with advancing age and its electrocardiographic basis has not been previously studied. Young (12-16 weeks) and aged (>52 weeks), WT (n = 5 and 8) and Pgc-1β(-/-) (n = 9 and 6), mice were anaesthetised and used for electrocardiographic (ECG) recordings. Time intervals separating successive ECG deflections were analysed for differences between groups before and after β1-adrenergic (intraperitoneal dobutamine 3 mg/kg) challenge...
September 26, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28942951/the-algorithmic-performance-of-j-tpeak-for-drug-safety-clinical-trial
#7
Simon C Chien, Richard E Gregg
INTRODUCTION: The interval from J-point to T-wave peak (JTp) in ECG is a new biomarker able to identify drugs that prolong the QT interval but have different ion channel effects. If JTp is not prolonged, the prolonged QT may be associated with multi ion channel block that may have low torsade de pointes risk. From the automatic ECG measurement perspective, accurate and repeatable measurement of JTp involves different challenges than QT. We evaluated algorithm performance and JTp challenges using the Philips DXL diagnostic 12/16/18-lead algorithm...
August 15, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28940299/a-history-of-drug-induced-torsades-de-pointes-is-associated-with-t-wave-morphological-abnormalities
#8
Tanveer A Bhuiyan, Claus Graff, Jørgen K Kanters, Jacob Melgaard, Egon Toft, Stefan Kääb, Johannes J Struijk
The hypothesis of the study is that TdP history can be better identified using T-wave morphology compared to QTcF at baseline. ECGs were recorded at baseline and during sotalol challenge in 20 patients with a history of TdP (+TdP) and 16 patients without previous TdP (-TdP). The Fridericia-corrected QT interval (QTcF) and T-wave morphology combination score (MCS) were calculated. At baseline, there was no significant difference in QTcF between the groups (+TdP: QTcF = 446±9 ms; -TdP: QTcF = 431±9 ms, p = 0...
September 22, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28934961/area-asymmetry-of-heart-rate-variability-signal
#9
Chang Yan, Peng Li, Lizhen Ji, Lianke Yao, Chandan Karmakar, Changchun Liu
BACKGROUND: Heart rate fluctuates beat-by-beat asymmetrically which is known as heart rate asymmetry (HRA). It is challenging to assess HRA robustly based on short-term heartbeat interval series. METHOD: An area index (AI) was developed that combines the distance and phase angle information of points in the Poincaré plot. To test its performance, the AI was used to classify subjects with: (i) arrhythmia, and (ii) congestive heart failure, from the corresponding healthy controls...
September 21, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28928069/comments-on-the-new-international-criteria-for-electrocardiographic-interpretation-in-athletes
#10
Luis Serratosa-Fernández, Domingo Pascual-Figal, María Dolores Masiá-Mondéjar, María Sanz-de la Garza, Zigor Madaria-Marijuan, Juan Ramón Gimeno-Blanes, Carmen Adamuz
Sudden cardiac death is the most common medical cause of death during the practice of sports. Several structural and electrical cardiac conditions are associated with sudden cardiac death in athletes, most of them showing abnormal findings on resting electrocardiogram (ECG). However, because of the similarity between some ECG findings associated with physiological adaptations to exercise training and those of certain cardiac conditions, ECG interpretation in athletes is often challenging. Other factors related to ECG findings are race, age, sex, sports discipline, training intensity, and athletic background...
September 16, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28918214/efficient-noise-tolerant-estimation-of-heart-rate-variability-using-single-channel-photoplethysmography
#11
Reza Firoozabadi, Eric D Helfenbein, Saeed Babaeizadeh
BACKGROUND: The feasibility of using photoplethysmography (PPG) for estimating heart rate variability (HRV) has been the subject of many recent studies with contradicting results. Accurate measurement of cardiac cycles is more challenging in PPG than ECG due to its inherent characteristics. METHODS: We developed a PPG-only algorithm by computing a robust set of medians of the interbeat intervals between adjacent peaks, upslopes, and troughs. Abnormal intervals are detected and excluded by applying our criteria...
August 18, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28912183/arrhythmogenic-cardiomyopathy
#12
REVIEW
Domenico Corrado, Cristina Basso, Daniel P Judge
Arrhythmogenic cardiomyopathy is an inherited heart muscle disorder, predisposing to sudden cardiac death, particularly in young patients and athletes. Pathological features include loss of myocytes and fibrofatty replacement of right ventricular myocardium; biventricular involvement is often observed. It is a cell-to-cell junction cardiomyopathy, typically caused by genetically determined abnormalities of cardiac desmosomes, which leads to detachment of myocytes and alteration of intracellular signal transduction...
September 15, 2017: Circulation Research
https://www.readbyqxmd.com/read/28894151/the-effects-of-ageing-and-adrenergic-challenge-on-electrocardiographic-phenotypes-in-a-murine-model-of-long-qt-syndrome-type-3
#13
Karan R Chadda, Shiraz Ahmad, Haseeb Valli, Ingrid den Uijl, Ali Bak Al-Hadithi, Samantha C Salvage, Andrew A Grace, Christopher L-H Huang, Kamalan Jeevaratnam
Long QT Syndrome 3 (LQTS3) arises from gain-of-function Nav1.5 mutations, prolonging action potential repolarisation and electrocardiographic (ECG) QT interval, associated with increased age-dependent risk for major arrhythmic events, and paradoxical responses to β-adrenergic agents. We investigated for independent and interacting effects of age and Scn5a+/ΔKPQ genotype in anaesthetised mice modelling LQTS3 on ECG phenotypes before and following β-agonist challenge, and upon fibrotic change. Prolonged ventricular recovery was independently associated with Scn5a+/ΔKPQ and age...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28887765/heartbeat-detection-in-multimodal-physiological-signals-using-signal-quality-assessment-based-on-sample-entropy
#14
Omkar Singh, Ramesh Kumar Sunkaria
This paper presents a novel technique to identify heartbeats in multimodal data using electrocardiogram (ECG) and arterial blood pressure (ABP) signals. Multiple physiological signals such as ECG, ABP, and Respiration are often recorded in parallel from the activity of heart. These signals generally possess related information as they are generated by the same physical system. The ECG and ABP correspond to the same phenomenon of contraction and relaxation activity of heart. Multiple signals acquired from various sensors are generally processed independently, thus discarding the information from other measurements...
September 8, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28885062/out-of-hospital-cardiac-arrest-always-coronary-angiography
#15
Andrea Rognoni, Chiara Cavallino, Marco Giovanni Mennuni, Lucia Barbieri, Roberta Rosso, Francesco Rametta, Federico Nardi, Alessandro Lupi, Angelo Sante Bongo
Out-of-hospital cardiac arrest (OHCA) remains one of the principle challenges in the setting of critical care medicine and emergency cardiology. Areas covered: Long-term survival rates even after successful resuscitation are variable but increasing in the recent years; due to the improvement of base and advanced cardiac life support techniques an increasing number of resuscitated patients are admitted to the hospital. Recent data suggested that patients surviving to hospital discharge after OHCA presented long-term outcome similar to patients with ST-elevation myocardial infarction...
November 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28874683/inter-patient-ecg-heartbeat-classification-with-temporal-vcg-optimized-by-pso
#16
Gabriel Garcia, Gladston Moreira, David Menotti, Eduardo Luz
Classifying arrhythmias can be a tough task for a human being and automating this task is highly desirable. Nevertheless fully automatic arrhythmia classification through Electrocardiogram (ECG) signals is a challenging task when the inter-patient paradigm is considered. For the inter-patient paradigm, classifiers are evaluated on signals of unknown subjects, resembling the real world scenario. In this work, we explore a novel ECG representation based on vectorcardiogram (VCG), called temporal vectorcardiogram (TVCG), along with a complex network for feature extraction...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28869899/a-deep-convolutional-neural-network-model-to-classify-heartbeats
#17
U Rajendra Acharya, Shu Lih Oh, Yuki Hagiwara, Jen Hong Tan, Muhammad Adam, Arkadiusz Gertych, Ru San Tan
The electrocardiogram (ECG) is a standard test used to monitor the activity of the heart. Many cardiac abnormalities will be manifested in the ECG including arrhythmia which is a general term that refers to an abnormal heart rhythm. The basis of arrhythmia diagnosis is the identification of normal versus abnormal individual heart beats, and their correct classification into different diagnoses, based on ECG morphology. Heartbeats can be sub-divided into five categories namely non-ectopic, supraventricular ectopic, ventricular ectopic, fusion, and unknown beats...
August 24, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28843654/pdf-ecg-in-clinical-practice-a-model-for-long-term-preservation-of-digital-12-lead-ecg-data
#18
Roberto Sassi, Raymond R Bond, Andrew Cairns, Dewar D Finlay, Daniel Guldenring, Guido Libretti, Lamberto Isola, Martino Vaglio, Roberto Poeta, Marco Campana, Claudio Cuccia, Fabio Badilini
BACKGROUND: In clinical practice, data archiving of resting 12-lead electrocardiograms (ECGs) is mainly achieved by storing a PDF report in the hospital electronic health record (EHR). When available, digital ECG source data (raw samples) are only retained within the ECG management system. OBJECTIVE: The widespread availability of the ECG source data would undoubtedly permit successive analysis and facilitate longitudinal studies, with both scientific and diagnostic benefits...
August 12, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28840587/study-design-and-rationale-for-biomedical-shirt-based-electrocardiography-monitoring-in-relevant-clinical-situations-ecg-shirt-study
#19
Paweł Balsam, Piotr Lodziński, Agata Tymińska, Krzysztof Ozierański, Łukasz Januszkiewicz, Renata Główczyńska, Katarzyna Wesołowska, Michał Peller, Radosław Pietrzak, Tomasz Książczyk, Sonia Borodzicz, Łukasz Kołtowski, Mariusz Borkowski, Bożena Werner, Grzegorz Opolski, Marcin Grabowski
BACKGROUND: Today, the main challenge for researchers is to develop new technologies which may help to improve the diagnoses of cardiovascular disease (CVD), thereby reducing healthcare costs and improving the quality of life for patients. This study aims to show the utility of biomedical shirt-based electrocardiography (ECG) monitoring of patients with CVD in different clinical situations using the Nuubo® ECG (nECG) system. METHODS: An investigator-initiated, multicentre, prospective observational study was carried out in a cardiology (adult and paediatric) and cardiac rehabilitation wards ...
August 25, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28800628/genome-wide-analysis-of-sotalol-induced-ikr-inhibition-during-ventricular-repolarization-generepol-study-lack-of-common-variants-with-large-effect-sizes
#20
Joe-Elie Salem, Marine Germain, Jean-Sébastien Hulot, Pascal Voiriot, Bruno Lebourgeois, Jean Waldura, David-Alexandre Tregouet, Beny Charbit, Christian Funck-Brentano
Many drugs used for non-cardiovascular and cardiovascular purposes, such as sotalol, have the side effect of prolonging cardiac repolarization, which can trigger life-threatening cardiac arrhythmias by inhibiting the potassium-channel IKr (KCNH2). On the electrocardiogram (ECG), IKr inhibition induces an increase in QTc and Tpeak-Tend (TpTe) interval and a decrease of T wave maximal amplitude (TAmp). These changes vary markedly between subjects, suggesting the existence of predisposing genetic factors. 990 healthy individuals, prospectively challenged with an oral 80mg sotalol dose, were monitored for changes in ventricular repolarization on ECG between baseline and 3 hours post dosing...
2017: PloS One
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