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https://www.readbyqxmd.com/read/28330968/examination-of-carnitine-palmitoyl-transferase-1-abundance-in-white-adipose-tissue-implications-in-obesity-research
#1
Jaycob D Warfel, Bolormaa Vandanmagsar, Olga S Dubuisson, Sydney M Hodgeson, Carrie M Elks, Eric Ravussin, Randall L Mynatt
Carnitine Palmitoyltransferase 1 (CPT1) is essential for the transport of long chain fatty acids into the mitochondria for oxidation. Recently, it was reported that decreased CPT1b mRNA in adipose tissue was a contributing factor for obesity in rats. We therefore closely examined the expression level of Cpt1 in adipose tissue from mice, rats, and humans. Cpt1a is the predominate isoform in adipose tissue from all three species. Rat white adipose tissue has a moderate amount of Cpt1b mRNA, but it is very minor compared to Cpt1b expression in muscle...
March 22, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28274727/serum-uric-acid-is-not-independently-associated-with-plasma-renin-activity-and-plasma-aldosterone-in-hypertensive-adults
#2
G Mulè, A Castiglia, M Morreale, G Geraci, C Cusumano, L Guarino, D Altieri, M Panzica, F Vaccaro, S Cottone
BACKGROUND AND AIMS: In experimental investigations conducted in rats, raising serum uric acid (SUA) levels resulted in the stimulation of intrarenal renin expression. Studies in humans exploring the association of SUA with plasma renin activity (PRA) yielded conflicting results. Moreover, little is known about the relationship of SUA with plasma aldosterone concentration (PAC). The study aimed to assess the relationship between SUA levels, PRA, and PAC and the influence of age, gender, body mass index (BMI), and hyperuricemia on these relationships in subjects with essential hypertension (EH)...
December 27, 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28268955/a-non-linear-mapping-algorithm-shaping-the-control-policy-of-a-bidirectional-brain-machine-interface
#3
Fabio Boi, Marianna Semprini, Alessandro Vato
Motor brain-machine interfaces (BMIs) transform neural activities recorded directly from the brain into motor commands to control the movements of an external object by establishing an interface between the central nervous system (CNS) and the device. Bidirectional BMIs are closed-loop systems that add a sensory channel to provide the brain with an artificial feedback signal produced by the interaction between the device and the external world. Taking inspiration from the functioning of the spinal cord in mammalians, in our previous works we designed and developed a bidirectional BMI that uses the neural signals recorded form rats' motor cortex to control the movement of an external object...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28243792/hmox1-as-a-marker-of-iron-excess-induced-adipose-tissue-dysfunction-affecting-glucose-uptake-and-respiratory-capacity-in-human-adipocytes
#4
José María Moreno-Navarrete, Francisco Ortega, Amaia Rodríguez, Jèssica Latorre, Sara Becerril, Mònica Sabater-Masdeu, Wifredo Ricart, Gema Frühbeck, José Manuel Fernández-Real
AIMS/HYPOTHESIS: Iron excess in adipose tissue is known to promote adipose tissue dysfunction. Here, we aimed to investigate the possible role of haem oxygenase 1 (HMOX1) in iron excess-induced adipose tissue dysfunction. METHODS: Cross-sectionally, HMOX1 gene expression in subcutaneous and visceral adipose tissue was analysed in two independent cohorts (n = 234 and 40) in relation to obesity. We also evaluated the impact of weight loss (n = 21), weight gain (in rats, n = 20) on HMOX1 mRNA; HMOX1 mRNA levels during human adipocyte differentiation; the effects of inflammation and iron on adipocyte HMOX1; and the effects of HMOX1-induced activity on adipocyte mitochondrial respiratory function, glucose uptake and adipogenesis...
February 27, 2017: Diabetologia
https://www.readbyqxmd.com/read/28242173/the-presence-of-cardiovascular-disease-does-not-modify-the-weak-impact-obesity-has-on-health-related-quality-of-life-in-patients-with-hip-osteoarthritis-in-the-khoala-cohort
#5
Laurie Renaudin, Francis Guillemin, Jacques Pouchot, Anne-Christine Rat
OBJECTIVE: In people with hip osteoarthritis (OA), the impact of obesity on health-related quality of life (HRQoL) remains unknown. Also whether cardiovascular conditions can modify the obesity-HRQoL relation has not been explored. We aimed to 1) study the cross-sectional relationship between body mass index (BMI) and HRQoL in symptomatic hip OA patients and determine whether cardiovascular comorbidity modifies this relationship and 2) examine the impact of BMI on the course of HRQoL over time...
February 24, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28235848/patients-with-long-qt-syndrome-due-to-impaired-herg-encoded-kv11-1-potassium-channel-have-exaggerated-endocrine-pancreatic-and-incretin-function-associated-with-reactive-hypoglycemia
#6
Louise Hyltén-Cavallius, Eva W Iepsen, Nicolai J Wewer Albrechtsen, Mathilde Svendstrup, Anniek F Lubberding, Bolette Hartmann, Thomas Jespersen, Allan Linneberg, Michael Christiansen, Henrik Vestergaard, Oluf Pedersen, Jens J Holst, Jørgen K Kanters, Torben Hansen, Signe S Torekov
Background -Loss-of-function mutations in hERG (encoding the Kv11.1 voltage-gated potassium channel) cause long QT syndrome (LQT2) due to prolonged cardiac repolarization. However, Kv11.1 is also present in pancreatic α and β cells and intestinal L and K cells, secreting glucagon, insulin, and the incretins glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), respectively. These hormones are crucial for glucose regulation and LQTS may cause disturbed glucose regulation. We measured secretion of these hormones and cardiac repolarization in response to glucose ingestion in LQT2 patients with functional mutations in hERG and matched healthy participants, testing the hypothesis that LQT2 patients have increased incretin and β cell- and decreased α cell function and thus lower glucose levels...
February 24, 2017: Circulation
https://www.readbyqxmd.com/read/28227162/a-non-linear-mapping-algorithm-shaping-the-control-policy-of-a-bidirectional-brain-machine-interface
#7
Fabio Boi, Marianna Semprini, Alessandro Vato, Fabio Boi, Marianna Semprini, Alessandro Vato, Fabio Boi, Marianna Semprini, Alessandro Vato
Motor brain-machine interfaces (BMIs) transform neural activities recorded directly from the brain into motor commands to control the movements of an external object by establishing an interface between the central nervous system (CNS) and the device. Bidirectional BMIs are closed-loop systems that add a sensory channel to provide the brain with an artificial feedback signal produced by the interaction between the device and the external world. Taking inspiration from the functioning of the spinal cord in mammalians, in our previous works we designed and developed a bidirectional BMI that uses the neural signals recorded form rats' motor cortex to control the movement of an external object...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28187014/delayed-donor-bone-marrow-infusion-induces-liver-transplant-tolerance
#8
Yan Xie, Yang Wu, Kang Xin, Jiao-Jing Wang, Hong Xu, Suzanne T Ildstad, Joseph Leventhal, Guang-Yu Yang, Zheng Zhang, Josh Levitsky
BACKGROUND: Nonmyeloablative conditioning followed by donor bone marrow infusion (BMI) to induce tolerance has not been robustly tested in liver transplantation (LT) and may be unsafe at the time of LT. We hypothesized T cell depleted BMI is effective in inducing tolerance when delayed after LT, resulting in potentially safer future clinical applications. METHODS: Nonimmunosuppressed syngeneic (Lewis to Lewis) and allogeneic (ACI to Lewis) rat LT transplants were initially performed as controls...
February 10, 2017: Transplantation
https://www.readbyqxmd.com/read/28132062/robot-assisted-choledochoduodenostomy-a-safe-and-reproducible-procedure-for-benign-common-bile-duct-obstruction
#9
Axel Gilbert, Alexandre Doussot, Pablo Ortega-Deballon, Florian Rostain, Patrick Rat, Olivier Facy
BACKGROUND: Choledochoduodenostomy (CD) is an option for treating choledocholithiasis and benign biliary obstruction after failure of endoscopic treatment. Nevertheless, this procedure is rarely performed using a mini-invasive approach because of its technical complexity. Robotic assistance could be a safer approach to overcome such technical issues. METHODS: All consecutive patients who underwent a robot-assisted CD for benign biliary obstruction were included...
January 28, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/28108289/negative-feedback-regulation-between-microrna-let-7g-and-lox-1-mediated-hypoxia-induced-pasmcs-proliferation
#10
Wei-Fang Zhang, Tian-Tian Zhu, You-Wen Xiong, Ai-Zhen Xiong, Xiao-Yue Ge, Chang-Ping Hu, Zheng Zhang
BACKGROUND: Pulmonary hypertension (PH) is a proliferative disorder associated with enhanced proliferation and suppressed apoptosis of pulmonary artery smooth muscle cells (PASMCs). Our lately study demonstrated that let-7g inhibited hypoxia-induced proliferation of PASMCs via repressing c-myc-Bmi-1-p16 signaling pathway. However, the upstream of let-7g has not yet been fully defined. Previous studies have shown that LOX-1, a target of let-7g, could also regulate the expression of let-7g in human aortic endothelial cells...
January 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28059450/kcnq1-variants-associate-with-hypertension-in-type-2-diabetes-and-affect-smooth-muscle-contractility-in-vitro
#11
Kuo-Chin Huang, Te-Mao Li, Xiang Liu, Jin-Hua Chen, Wen-Kuei Chien, Yi-Tzone Shiao, Hsinyi Tsang, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Ju-Pi Li, Cheng-Wen Lin, Jung-Chun Lin, Chih-Chien Lin, Chih-Ho Lai, Chi-Fung Cheng, Wen-Miin Liang, Chien-Hui Hung, Ching-Chu Chen, Ying-Ju Lin, Fuu Jen-Tsai
KCNQ1 encodes a potassium voltage-gated channel and represents a susceptibility locus for type 2 diabetes mellitus (T2DM). Here, we explored the association between KCNQ1 polymorphisms and hypertension risk in individuals with T2DM, as well as the role of KCNQ1 in vascular smooth muscle cell contraction in vitro. To investigate the relationship between KCNQ1 and the risk of developing hypertension in patients with T2DM, we divided the T2DM cohort into hypertension (n = 452) and non-hypertension (n = 541) groups...
January 6, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28018162/a-bidirectional-brain-machine-interface-featuring-a-neuromorphic-hardware-decoder
#12
Fabio Boi, Timoleon Moraitis, Vito De Feo, Francesco Diotalevi, Chiara Bartolozzi, Giacomo Indiveri, Alessandro Vato
Bidirectional brain-machine interfaces (BMIs) establish a two-way direct communication link between the brain and the external world. A decoder translates recorded neural activity into motor commands and an encoder delivers sensory information collected from the environment directly to the brain creating a closed-loop system. These two modules are typically integrated in bulky external devices. However, the clinical support of patients with severe motor and sensory deficits requires compact, low-power, and fully implantable systems that can decode neural signals to control external devices...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27938548/-effect-of-oxidative-stress-associated-damage-to-the-lung-tissue-caused-by-different-body-mass-index-in-the-rat-models
#13
X Y Li, X J Zhang, J H Zhao, J Y Xu
Objective: To investigate the influence of different diets on serum protein expression levels of 4-hydroxynonenal (4-HNE), thioredoxin (Trx), thioredoxin reductase (TrxR) and the activities of Trx and TrxR, and to explore the effect of damage to the lung tissue and the underlying mechanisms of different body mass index caused by different diets in the rat models . Method: Healthy clean male SD rats were randomly divided into normal group, emaciation group and fat group, which were raised by different diets for 6 months...
December 12, 2016: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/27905126/ameliorating-effects-of-fennel-and-cumin-extracts-on-sperm-quality-and-spermatogenic-cells-apoptosis-by-inducing-weight-loss-and-reducing-leptin-concentration-in-diet-induced-obese-rats
#14
R Nejatbakhsh, S Riyahi, A Farrokhi, S Rostamkhani, S Mahmazi, A Yazdinezhad, M Kazemi, S Shokri
This study was established a model of obesity to estimate the impact of fennel and cumin as anti-obesity extracts on body weight, body mass index (BMI), food consumption, leptin concentration, sperm quality and testis architecture to determine the reversibility of reproductive function of obese animals. Male rats were randomly assigned to either a normal or high-fat diet for 8 weeks. Then, we divided 56 adult rats into seven groups: control (CO); obesity (OB); fennel 100 and 200 mg/kg; cumin 50 and 100 mg/kg; and fennel 100 mg/kg plus cumin 50 mg/kg...
November 30, 2016: Andrologia
https://www.readbyqxmd.com/read/27894971/aqueous-seed-extract-of-hunteria-umbellata-k-schum-hallier-f-apocynaceae-palliates-hyperglycemia-insulin-resistance-dyslipidemia-inflammation-and-oxidative-stress-in-high-fructose-diet-induced-metabolic-syndrome-in-rats
#15
T O Ajiboye, A A Hussaini, B Y Nafiu, O B Ibitoye
ETHNOPHARMACOLOGICAL RELEVANCE: Hunteria umbellata is used in the management and treatment of diabetes and obesity in Nigeria. This study evaluates the effect of aqueous seed extract of Hunteria umbellata on insulin resistance, dyslipidemia, inflammation and oxidative stress in high-fructose diet-induced metabolic syndrome. MATERIALS AND METHODS: Rats were randomized into seven groups (A-G). Control (group A) and group C rats received control diet for nine weeks while rats in groups B, D - G were placed on high-fructose diet for 9 weeks...
November 25, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27889560/microrna-let-7g-inhibited-hypoxia-induced-proliferation-of-pasmcs-via-g0-g1-cell-cycle-arrest-by-targeting-c-myc
#16
Wei-Fang Zhang, You-Wen Xiong, Tian-Tian Zhu, Ai-Zhen Xiong, Hui-Hui Bao, Xiao-Shu Cheng
AIMS: Pulmonary hypertension (PH) is a proliferative disorder characterized by enhanced proliferation and suppressed apoptosis of intrapulmonary vascular smooth muscle cells. Recently, network-based bioinformatics have identified let-7 family, a tumor suppressive microRNA, regulate multiple interacting targets relevant to PH. However, the role of let-7 in vascular homeostasis in PH remains unknown. Thus, we wanted to investigate the role of let-7 in hypoxia-induced PASMCs proliferation and the underlying mechanism in hypoxic pulmonary hypertension (HPH)...
February 1, 2017: Life Sciences
https://www.readbyqxmd.com/read/27863203/safflower-catharmus-tinctorius-l-oil-supplementation-in-overnourished-rats-during-early-neonatal-development-effects-on-heart-and-liver-function-in-the-adult
#17
COMPARATIVE STUDY
Laís Ribeiro Costa, Patrícia Cavalcanti Macêdo, Janatar Stella Vasconcelos de Melo, Cristiane Moura Freitas, Aiany Simoes Alves, Humberto de Moura Barbosa, Eduardo Lira, Mariana Pinheiro Fernandes, Manuella Batista-de-Oliveira-Hornsby, Claudia Lagranha
Carthamus tinctorius L. (common name: safflower) is an herb whose extracted oil (safflower oil) has been employed in both alternative and conventional medicine in the treatment of disease. Overnutrition during early postnatal life can increase the lifetime risk of obesity and metabolic syndrome. Here we investigate the effect of safflower oil supplementation given during a critical early developmental stage on the eventual occurrence of metabolic disease in overnourished rats. Groups of overnourished or adequately nourished rats were randomly assigned into 2 additional groups for supplementation with either safflower oil (SF) or vehicle for 7 to 30 days...
December 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/27767063/continuous-force-decoding-from-local-field-potentials-of-the-primary-motor-cortex-in-freely-moving-rats
#18
Abed Khorasani, Nargess Heydari Beni, Vahid Shalchyan, Mohammad Reza Daliri
Local field potential (LFP) signals recorded by intracortical microelectrodes implanted in primary motor cortex can be used as a high informative input for decoding of motor functions. Recent studies show that different kinematic parameters such as position and velocity can be inferred from multiple LFP signals as precisely as spiking activities, however, continuous decoding of the force magnitude from the LFP signals in freely moving animals has remained an open problem. Here, we trained three rats to press a force sensor for getting a drop of water as a reward...
October 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27753977/os-12-04-taurine-supplementation-lowers-blood-pressure-and-reduces-carotid-intima-media-thickness-in-prehypertension
#19
Bin Wang, Qianqian Sun, Yingsha Li, Peng Li, Weijie Xia, Daoyan Liu, Zhiming Zhu
OBJECTIVE: Taurine, the most abundant, semiessential, sulfur-containing amino acid, is well known to improve metabolic status in animal models. However, no rigorous clinical trial has validated whether this beneficial effect of taurine occurs in human, especially in prehypertensive participants. DESIGN AND METHOD: In this randomized, double-blind, placebo-controlled study, we assessed the effects of taurine intervention on metabolic parameters, such as blood pressure (BP) levels, carotid intima-media thickness (IMT), ankle brachial index (ABI)/toe brachial index (TBI), BMI and biochemical parameters in prehypertensive participants...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27738744/toxicokinetics-and-internal-exposure-of-acrylamide-new-insight-into-comprehensively-profiling-mercapturic-acid-metabolites-as-short-term-biomarkers-in-rats-and-chinese-adolescents
#20
Qiao Wang, Xinyu Chen, Yiping Ren, Qing Chen, Zhen Meng, Jun Cheng, Yunyan Zheng, Weijiang Zeng, Qingning Zhao, Yu Zhang
Acrylamide is classified as a probable carcinogen to humans and generated from Maillard reaction. Currently, the short-term exposure to acrylamide was evaluated via external diet sources in vitro or two main mercapturic acid metabolites: N-acetyl-S-(2-carbamoylethyl)-L-cysteine (AAMA) and N-acetyl-S-(2-carbamoyl-2-hydroxyethyl)-L-cysteine (GAMA) in vivo. In the present work, we comprehensively profiled four mercapturic acid metabolites and evaluated their internal exposure in rats and Chinese adolescents. The cumulative excretion of mercapturic acid metabolites contributes 38...
October 13, 2016: Archives of Toxicology
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