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https://www.readbyqxmd.com/read/27905126/ameliorating-effects-of-fennel-and-cumin-extracts-on-sperm-quality-and-spermatogenic-cells-apoptosis-by-inducing-weight-loss-and-reducing-leptin-concentration-in-diet-induced-obese-rats
#1
R Nejatbakhsh, S Riyahi, A Farrokhi, S Rostamkhani, S Mahmazi, A Yazdinezhad, M Kazemi, S Shokri
This study was established a model of obesity to estimate the impact of fennel and cumin as anti-obesity extracts on body weight, body mass index (BMI), food consumption, leptin concentration, sperm quality and testis architecture to determine the reversibility of reproductive function of obese animals. Male rats were randomly assigned to either a normal or high-fat diet for 8 weeks. Then, we divided 56 adult rats into seven groups: control (CO); obesity (OB); fennel 100 and 200 mg/kg; cumin 50 and 100 mg/kg; and fennel 100 mg/kg plus cumin 50 mg/kg...
November 30, 2016: Andrologia
https://www.readbyqxmd.com/read/27894971/aqueous-seed-extract-of-hunteria-umbellata-k-schum-hallier-f-apocynaceae-palliates-hyperglycemia-insulin-resistance-dyslipidemia-inflammation-and-oxidative-stress-in-high-fructose-diet-induced-metabolic-syndrome-in-rats
#2
T O Ajiboye, A A Hussaini, B Y Nafiu, O B Ibitoye
ETHNOPHARMACOLOGICAL RELEVANCE: Hunteria umbellata is used in the management and treatment of diabetes and obesity in Nigeria. This study evaluates the effect of aqueous seed extract of Hunteria umbellata on insulin resistance, dyslipidemia, inflammation and oxidative stress in high-fructose diet-induced metabolic syndrome. MATERIALS AND METHODS: Rats were randomized into seven groups (A-G). Control (group A) and group C rats received control diet for nine weeks while rats in groups B, D - G were placed on high-fructose diet for 9 weeks...
November 25, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27889560/microrna-let-7g-inhibited-hypoxia-induced-proliferation-of-pasmcs-via-g0-g1-cell-cycle-arrest-by-targeting-c-myc
#3
Wei-Fang Zhang, You-Wen Xiong, Tian-Tian Zhu, Ai-Zhen Xiong, Hui-Hui Bao, Xiao-Shu Cheng
AIMS: Pulmonary hypertension (PH) is a proliferative disorder characterized by enhanced proliferation and suppressed apoptosis of intrapulmonary vascular smooth muscle cells. Recently, network-based bioinformatics have identified let-7 family, a tumor suppressive microRNA, regulate multiple interacting targets relevant to PH. However, the role of let-7 in vascular homeostasis in PH remains unknown. Thus, we wanted to investigate the role of let-7 in hypoxia-induced PASMCs proliferation and the underlying mechanism in hypoxic pulmonary hypertension (HPH)...
November 23, 2016: Life Sciences
https://www.readbyqxmd.com/read/27863203/safflower-catharmus-tinctorius-l-oil-supplementation-in-overnourished-rats-during-early-neonatal-development-effects-on-heart-and-liver-function-in-the-adult
#4
Laís Ribeiro Costa, Patrícia Cavalcanti Macêdo, Janatar Stella Vasconcelos de Melo, Cristiane Moura Freitas, Aiany Simoes Alves, Humberto de Moura Barbosa, Eduardo Lira, Mariana Pinheiro Fernandes, Manuella Batista-de-Oliveira-Hornsby, Claudia Lagranha
Carthamus tinctorius L. (common name: safflower) is an herb whose extracted oil (safflower oil) has been employed in both alternative and conventional medicine in the treatment of disease. Overnutrition during early postnatal life can increase the lifetime risk of obesity and metabolic syndrome. Here we investigate the effect of safflower oil supplementation given during a critical early developmental stage on the eventual occurrence of metabolic disease in overnourished rats. Groups of overnourished or adequately nourished rats were randomly assigned into 2 additional groups for supplementation with either safflower oil (SF) or vehicle for 7 to 30 days...
December 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/27767063/continuous-force-decoding-from-local-field-potentials-of-the-primary-motor-cortex-in-freely-moving-rats
#5
Abed Khorasani, Nargess Heydari Beni, Vahid Shalchyan, Mohammad Reza Daliri
Local field potential (LFP) signals recorded by intracortical microelectrodes implanted in primary motor cortex can be used as a high informative input for decoding of motor functions. Recent studies show that different kinematic parameters such as position and velocity can be inferred from multiple LFP signals as precisely as spiking activities, however, continuous decoding of the force magnitude from the LFP signals in freely moving animals has remained an open problem. Here, we trained three rats to press a force sensor for getting a drop of water as a reward...
October 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27753977/os-12-04-taurine-supplementation-lowers-blood-pressure-and-reduces-carotid-intima-media-thickness-in-prehypertension
#6
Bin Wang, Qianqian Sun, Yingsha Li, Peng Li, Weijie Xia, Daoyan Liu, Zhiming Zhu
OBJECTIVE: Taurine, the most abundant, semiessential, sulfur-containing amino acid, is well known to improve metabolic status in animal models. However, no rigorous clinical trial has validated whether this beneficial effect of taurine occurs in human, especially in prehypertensive participants. DESIGN AND METHOD: In this randomized, double-blind, placebo-controlled study, we assessed the effects of taurine intervention on metabolic parameters, such as blood pressure (BP) levels, carotid intima-media thickness (IMT), ankle brachial index (ABI)/toe brachial index (TBI), BMI and biochemical parameters in prehypertensive participants...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27738744/toxicokinetics-and-internal-exposure-of-acrylamide-new-insight-into-comprehensively-profiling-mercapturic-acid-metabolites-as-short-term-biomarkers-in-rats-and-chinese-adolescents
#7
Qiao Wang, Xinyu Chen, Yiping Ren, Qing Chen, Zhen Meng, Jun Cheng, Yunyan Zheng, Weijiang Zeng, Qingning Zhao, Yu Zhang
Acrylamide is classified as a probable carcinogen to humans and generated from Maillard reaction. Currently, the short-term exposure to acrylamide was evaluated via external diet sources in vitro or two main mercapturic acid metabolites: N-acetyl-S-(2-carbamoylethyl)-L-cysteine (AAMA) and N-acetyl-S-(2-carbamoyl-2-hydroxyethyl)-L-cysteine (GAMA) in vivo. In the present work, we comprehensively profiled four mercapturic acid metabolites and evaluated their internal exposure in rats and Chinese adolescents. The cumulative excretion of mercapturic acid metabolites contributes 38...
October 13, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27732892/decreasing-gaba-function-within-the-medial-prefrontal-cortex-or-basolateral-amygdala-decreases-sociability
#8
Tracie A Paine, Nathan Swedlow, Lucien Swetschinski
INTRODUCTION: Decreased sociability is a symptom of psychiatric conditions including autism-spectrum disorder and schizophrenia. Both of these conditions are associated with decreases in GABA function, particularly in the medial prefrontal cortex (PFC) and the basolateral amygdala (BLA); structures that are components of the social brain. Here, we determined if decreasing GABA transmission within either the PFC or the BLA decreases social behavior. METHODS: Rats were implanted with cannulae aimed at either the medial PFC or the BLA and then were tested on up to 4 behavioral tests following bilateral infusions of 0...
January 15, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/27714571/correlation-of-tlr4-and-klf7-in-inflammation-induced-by-obesity
#9
Cuizhe Wang, Xiaodan Ha, Wei Li, Peng Xu, Yajuan Gu, Tingting Wang, Yan Wang, Jianxin Xie, Jun Zhang
Objective Recent studies have revealed a link between toll-like receptors (TLRs), Kruppel-like factors (KLFs), and the adipose tissue inflammation associated with obesity. TLR4 is associated with chronic inflammation in obesity. KLF7 is known to play an important role in the differentiation of adipocytes, but its role in visceral adipose tissue inflammation has not yet been investigated. Thus, the objective of this study was to determine the correlation of TLR4 and KLF7 in inflammation induced by obesity. Methods A total of 32 Wistar male rat subjects were fed in the center for experimental animals of Shihezi University...
October 6, 2016: Inflammation
https://www.readbyqxmd.com/read/27650100/the-impact-of-a-junk-food-diet-during-development-on-wanting-and-liking
#10
Ellen Nacha Lesser, Aime Arroyo-Ramirez, Sarah Jingyi Mi, Mike James Ferrar Robinson
The global increase in obesity rates has been tied to the rise in junk-food availability and consumption. Increasingly, children are exposed to a junk-food diet during gestation and early development. Excessive consumption of junk-food during this period may negatively impact the development of brain motivation and reward pathways. In this study we investigated the effects of a chronic junk-food diet throughout development on cue-motivated behavior ('wanting'), hedonic 'liking' for sweet tastes, as well as anxiety and weight gain in male and female Long-Evans (LE) and Sprague-Dawley (SD) rats...
September 17, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27643374/os-12-04-taurine-supplementation-lowers-blood-pressure-and-reduces-carotid-intima-media-thickness-in-prehypertension
#11
Bin Wang, Qianqian Sun, Yingsha Li, Peng Li, Weijie Xia, Daoyan Liu, Zhiming Zhu
OBJECTIVE: Taurine, the most abundant, semiessential, sulfur-containing amino acid, is well known to improve metabolic status in animal models. However, no rigorous clinical trial has validated whether this beneficial effect of taurine occurs in human, especially in prehypertensive participants. DESIGN AND METHOD: In this randomized, double-blind, placebo-controlled study, we assessed the effects of taurine intervention on metabolic parameters, such as blood pressure (BP) levels, carotid intima-media thickness (IMT), ankle brachial index (ABI)/toe brachial index (TBI), BMI and biochemical parameters in prehypertensive participants...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27568876/dioscoreophyllum-cumminsii-stapf-diels-leaves-halt-high-fructose-induced-metabolic-syndrome-hyperglycemia-insulin-resistance-inflammation-and-oxidative-stress
#12
T O Ajiboye, H Aliyu, M A Tanimu, R M Muhammad, O B Ibitoye
ETHNOPHARMACOLOGICAL RELEVANCE: Dioscoreophyllum cumminsii is widely used in the management and treatment of diabetes and obesity in Nigeria. This study evaluates the effect of aqueous leaf extract of D. cumminsii on high-fructose diet-induced metabolic syndrome. METHODS: Seventy male rats were randomized into seven groups. All rats were fed with high-fructose diet for 9 weeks except groups A and C rats, which received control diet. In addition to the diet treatment, groups A and B rats received distilled water for 3 weeks starting from the seventh week of the experimental period...
November 4, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27566182/high-fat-diet-induced-obesity-facilitates-anxiety-like-behaviors-due-to-gabaergic-impairment-within-the-dorsomedial-hypothalamus-in-rats
#13
Sylvana Rendeiro de Noronha, Glenda Viggiano Campos, Aline Rezende Abreu, Aline Arlindo de Souza, Deoclécio A Chianca, Rodrigo C de Menezes
Overweight and obesity are conditions associated with an overall range of clinical health consequences, and they could be involved with the development of neuropsychiatric diseases, such as generalized anxiety disorder (GAD) and panic disorder (PD). A crucial brain nuclei involved on the physiological functions and behavioral responses, especially fear, anxiety and panic, is the dorsomedial hypothalamus (DMH). However, the mechanisms underlying the process whereby the DMH is involved in behavioral changes in obese rats still remains unclear...
January 1, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/27564291/low-serum-insulin-like-growth-factor-1-in-patients-with-stress-urinary-incontinence
#14
Emin Ozbek, Alper Otunctemur, Suleyman Sahin, Levent Ozcan, Murat Dursun, Emrecan Polat, Feti Tulubas, Mustafa Cekmen
OBJECTIVE: SUI, involuntary loss of urine, occurs when intra abdominal pressure exceeds urethral pressure in women. Recent animal study has shown that there are therapeutic effects of Insulin-like growth factors (IGF-1) on stress urinary incontinence in rats with simulated childbirth trauma. IGF-1 is an important mediator of cell growth, differentiation and transformation in various tissues and stimulates fibroblast proliferation and enhances collagen synthesis. The purpose of the current study was to determine the association between IGF-1 levels and SUI...
July 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27508997/recognition-memory-and-dna-damage-in-undernourished-young-rats
#15
Patrícia Molz, Joel H Ellwanger, Fernanda F Zenkner, Deivis DE Campos, Daniel Prá, Marisa T L Putzke, Silvia I R Franke
This study evaluated the recognition memory and the levels of DNA damage (blood and hippocampus) in undernourished young Wistar rats. The experiment was conducted along 14-week with rodents divided in control group (CG, n=8) and undernourished group (UG, n=12) which was submitted to caloric restriction. Nutritional status for undernutrition was defined by Body Mass Index (BMI) ≤0.45g/cm2 and by weighting the organs/tissue (liver, spleen, intestine, peritoneal fat, kidney and encephalon). The Novel Object Recognition Test assessed recognition memory and the Comet Assay evaluated the levels of DNA damage...
2016: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/27508802/-op-1c-01-high-salt-diet-increases-aortic-stiffness-and-pressure-pulse-amplification-in-rat
#16
M Butlin, K Connolly, B Spronck, D Georgevsky, C Mceneiry, I Wilkinson, A Avolio
OBJECTIVE: High salt consumption is associated with increased blood pressure and vascular changes in humans. This association is confounded by other lifestyle factors that could equally influence cardiovascular function. This study examines effects of high salt diet on aortic function in a controlled animal study. DESIGN AND METHOD: Sprague-Dawley rats were fed either high salt (8% sodium chloride, n = 6) or normal chow (0.26% sodium chloride, n = 5) from weaning...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27508598/-op-lb03-09-the-acute-effect-of-the-specific-creatine-kinase-inhibitor-beta-gpa-in-healthy-man-abc-trial-a-randomized-placebo-and-active-controlled-first-in-human-trial
#17
F A Karamat, D Horjus, Y Haan, L Van Der Woude, M Schaap, I Oudman, G Van Montfrans, R Nieuwland, J Clark, A Sturk, L Brewster
OBJECTIVE: There is increasing evidence that the ATP generating enzyme creatine kinase (CK) is involved in hypertension. The enzyme is central to the regeneration of ATP by using creatine phosphate and ADP, thereby forming creatine and ATP. We recently showed that beta-guanidinopropionic acid (GPA), a creatine analogue and competitive CK inhibitor, effectively and safely reduced blood pressure in the spontaneously hypertensive rat. This renders GPA to be potentially beneficial for blood pressure lowering...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27468463/effect-of-hydroalcoholic-fruit-extract-of-persea-americana-mill-on-high-fat-diet-induced-obesity-a-dose-response-study-in-rats
#18
Padmanabhan Monika, Arumugam Geetha
The fruits of Persea Americana Mill., commonly known as Avocado, are traditionally consumed for various health benefits including weight reduction. Here, we studied the effect of hydroalcoholic fruit extract of Persea americana (HAEPA) on high fat diet (HFD) induced obesity in rats. Obesity was induced in male Sprague Dawley rats by feeding HFD for 14 wk. The hypolipidemic effect was evaluated by co-administering 25, 50, 100 and 200 mg/kg body wt. of HAEPA. There was a significant increase in weight gain, body mass index (BMI), blood lipids, low density lipoproteins (LDL), lipid peroxides (LPO) and serum transaminases in HFD fed rats...
June 2016: Indian Journal of Experimental Biology
https://www.readbyqxmd.com/read/27409634/relationships-of-dietary-histidine-and-obesity-in-northern-chinese-adults-an-internet-based-cross-sectional-study
#19
Yan-Chuan Li, Chun-Long Li, Jia-Yue Qi, Li-Na Huang, Dan Shi, Shan-Shan Du, Li-Yan Liu, Ren-Nan Feng, Chang-Hao Sun
Our previous studies have demonstrated that histidine supplementation significantly ameliorates inflammation and oxidative stress in obese women and high-fat diet-induced obese rats. However, the effects of dietary histidine on general population are not known. The objective of this Internet-based cross-sectional study was to evaluate the associations between dietary histidine and prevalence of overweight/obesity and abdominal obesity in northern Chinese population. A total of 2376 participants were randomly recruited and asked to finish our Internet-based dietary questionnaire for the Chinese (IDQC)...
2016: Nutrients
https://www.readbyqxmd.com/read/27333958/aster-spathulifolius-maxim-extract-reduces-body-weight-and-fat-mass-in-obese-humans
#20
In-Jin Cho, Se Young Choung, You-Cheol Hwang, Kyu Jeung Ahn, Ho Yeon Chung, In-Kyung Jeong
Aster spathulifolius Maxim (AS), a perennial herb of the genus Aster within the family Asteraceae, induced weight loss in a rat model of diet-induced obesity. We hypothesized that AS could also reduce body weight in obese humans. Therefore, we performed a randomized, double-blind, placebo-controlled clinical trial in Korea to evaluate the effect of AS extract (ASE) on body weight and fat mass and its safety in obese humans. Forty-four obese participants (body mass index [BMI], 25-30 kg/m(2)) aged ≥20 years were randomly assigned to the placebo or ASE group (700 mg/d of ASE) and were instructed to take a once-daily pill for 12 weeks...
July 2016: Nutrition Research
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