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https://www.readbyqxmd.com/read/28454062/self-assembled-dehydropeptide-nano-carriers-for-delivery-of-ornidazole-and-curcumin
#1
Smriti Rekha Deka, Santosh Yadav, Dheeresh Kumar, Sumit Garg, Manohar Mahato, Ashwani Kumar Sharma
In the recent studies, it has been demonstrated that incorporation of unnatural amino acid, α,β-dehydrophenylalanine, in small peptides results in stable self-assembled nanostructures with different sizes and shapes. Here, we have replaced the natural amino acid, phenylalanine, from our earlier reported work on self-assembled peptide, Boc-Pro-Phe-Gly-OMe, with a constrained dehydro amino acid, α,β-dehydrophenylalanine, to study its influence on self-assembled nanostructures. Dehydrotripeptide, Boc-Pro-ΔPhe-Gly-OMe, self-assembled into nanostructures in aqueous solutions and formed hydrophobic matrix with improved encapsulation efficiency of hydrophobic molecules...
April 20, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28453939/all-atom-molecular-dynamics-simulations-of-peptide-amphiphile-assemblies-that-spontaneously-form-twisted-and-helical-ribbon-structures
#2
Cheng-Tsung Lai, Nathaniel L Rosi, George C Schatz
Self-assembly of peptide amphiphiles (PAs) has been an active research area as the assemblies can be programmed into various shaped nanostructures. Although cylindrical micelles are common structures, gold-binding peptide conjugates PEPAu can self-assemble into chiral nanofibers with single or double helices. When gold nanoparticles bind to the helices, the resulting chiral nanoparticle assemblies have a collective plasmonic circular dichroism signal that can serve as nanoscale circular polarizers or chiroptical sensors...
April 28, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28453900/the-kinetics-of-growth-of-metallo-supramolecular-polyelectrolytes-in-solution
#3
Stefanie Martina Munzert, Simon P Stier, Guntram Schwarz, Haim Weissman, Boris Rybtchinski, Dirk G Kurth
Several transition metal ions, like Fe2+, Co2+, Ni2+, and Zn2+ complex to the ditopic ligand 1,4-bis(2,2':6',2''-terpyridin-4'-yl)benzene (L). Due to the high association constant, metal ion induced self-assembly of Fe2+, Co2+, and Ni2+ leads to extended, rigid-rod like metallo-supramolecular coordination polyelectrolytes (MEPEs) even in aqueous solution. Here, we present the kinetics of growth of MEPEs. The species in solutions are analyzed by light scattering, viscometry and Cryogenic Transmission Electron microscopy (cryo-TEM)...
April 28, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28449542/estimation-of-the-number-of-quantum-dots-immobilized-on-an-ultra-flat-au-surface
#4
Hiroki Ito, Atsushi Iio, Katsutoshi Tokuhara, Hiroyuki Sakaue, Yutaka Kadoya, Hitoshi Suzuki
Quantum dots (QDs) were immobilized on an ultra-flat Au surface by using amide binding between the carboxyl groups on the QDs and the amino groups of the self-assembled monolayer on the surface. The number density of the QDs estimated by atomic force microscopy (AFM) agreed with the quantity of QDs estimated by X-ray photoelectron spectroscopy and fluorescence microscopy. QDs were also immobilized on dot patterns fabricated by e-beam lithography. AFM was able to identify clusters of just a few QDs on the dot patterns, whose minimum designed size was 50 nm × 50 nm per dot...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28449250/self-assembly-of-peptide-boroxoles-on-cis-dihydroxylated-oligoamide-templates-in-water
#5
André Wuttke, Armin Geyer
We develop templates that can be used to stabilize consistent oligomers of a bioactive peptide. In the present study, we synthesize oligomers of an antibody epitope from the amyloidogenic prion protein. Dynamic covalent chemistry is the basis for the spontaneous condensation of 2, 3, 4 or 6 peptides with qualified polyol templates presenting the required number of bioorthogonal ligation sites. To study this process in aqueous solution, the N-terminal amino acid of a 13-mer peptide is first acylated with 4-carboxy-benzoboroxole (1-hydroxy-1,3-dihydrobenzo[c][1,2] oxaborole-5-carboxylic acid) and then mixed with the template to obtain self-assembled miniamyloids of specified degree of oligomerization...
April 27, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28448818/pegylated-bilirubin-nanoparticle-as-an-anti-oxidative-and-anti-inflammatory-demulcent-in-pancreatic-islet-xenotransplantation
#6
Min Jun Kim, Yonghyun Lee, Sangyong Jon, Dong Yun Lee
Transplanted islets suffer hypoxic stress, which leads to nonspecific inflammation. This is the major cause of islet graft failure during the early stage of intrahepatic islet transplantation. Although bilirubin has shown potent anti-oxidative and anti-inflammatory functions, its clinical applications have been limited due to its insolubility and short half-life. To overcome this problem, novel amphiphilic bilirubin nanoparticles are designed. Hydrophilic poly(ethylene glycol) (PEG) is conjugated to the hydrophobic bilirubin molecule...
April 18, 2017: Biomaterials
https://www.readbyqxmd.com/read/28448714/octopus-inspired-assembly-of-nanosucker-arrays-for-dry-wet-adhesion
#7
Ying-Chu Chen, Hongta Yang
The octopus is able to adhere to slippery, fouled and irregular surfaces in the marine intertidal environment, because of its periodic infundibulum-shaped suckers on the arms. Here, we report a scalable self-assembly technique for fabricating adhesion materials that mimic octopus-sucker functionality. By utilizing spin-coated two-dimensional colloidal crystals as templates, non-close-packed nanosucker arrays are patterned on silicone substrates. The resulting nanosuckers can be deformed to exhibit great adhesive capacities on both micro-rough and flat surfaces in dry and wet environments...
April 27, 2017: ACS Nano
https://www.readbyqxmd.com/read/28448600/mscs-feeder-layers-induce-smg-self-organization-and-branching-morphogenesis
#8
Mahmoud Farahat, Gulsan Ara Sathi, Emilio Satoshi Hara, Hiroaki Taketa, Takuo Kuboki, Takuya Matsumoto
Dysfunction of salivary glands leads to several oral health problems, including dental caries, mastication and swallowing dysfunctions and multiple oral infections. Conventional treatments for such condition fell short of providing satisfying therapeutic results. Recent advances in organ regeneration therapy which utilize tissue stem cells to fabricate bioengineered 3D organ buds, have introduced a promising therapeutic tool for full functional organ regeneration. However, finding a sustainable and easily accessible cell source for such approaches is still challenging, especially in case of severely atrophied tissues such as irradiated salivary glands...
2017: PloS One
https://www.readbyqxmd.com/read/28448117/eliminating-the-animal-species-constraints-in-antibody-selection-for-multicolor-immunoassays
#9
Yao Sun, Xiaohu Gao
Molecular profiling on the single-cell level helps unveil the mystery of gene expression patterns in individual cells at subcellular resolution, enabling discovery of small but meaningful variations that are often overlooked at the population level. Similar to other immunoassays, the most common and economical protocols are developed by combining primary antibodies (1'Abs) and fluorophore-labeled secondary antibodies (2'Abs). The selection of 1' and 2' Abs, however, has been limited by the availability of animal species, consequently resulting in low multiplexing capability...
April 27, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28447683/self-assembled-hybrid-elastin-like-polypeptide-silica-nanoparticles-enable-triggered-drug-release
#10
Wei Han, Ashutosh Chilkoti, Gabriel P López
The discovery of biomimetic polypeptides that enable the biomineralization of synthetic and biosynthetic materials has resulted in the development of hybrid materials that incorporate inorganic components for potential application in drug delivery, enzyme immobilization, and surface modification. Here, we describe an approach that uses micellar assemblies of an elastin-like polypeptide (ELP) modified with silica-promoting sequences and drug conjugates that are subsequently encapsulated within a silica matrix...
April 27, 2017: Nanoscale
https://www.readbyqxmd.com/read/28447085/studying-structure-and-dynamics-of-self-assembled-peptide-nanostructures-using-fluorescence-and-super-resolution-microscopy
#11
Sílvia Pujals, Kai Tao, Adrià Terradellas, Ehud Gazit, Lorenzo Albertazzi
Understanding the formation and properties of self-assembled peptide nanostructures is the basis for the design of new architectures for various applications. Here we show the potential of fluorescence and super resolution imaging to unveil the structural and dynamic features of peptide nanofibers with high spatiotemporal resolution.
April 27, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28446346/engineering-nanosized-organosilica-for-molecular-recognition-and-biocatalysis-applications
#12
M Rita Correro, Yves Dudal, Philippe F-X Corvini, Patrick Shahgaldian
A series of synthetic nanomaterials capable of molecular recognition and/or biocatalysis have been produced by exploiting the self-sorting, self-assembly and polycondensation of organosilane building blocks around protein templates. The established methodology allows for the production of thin organosilica layers of controlled thickness, down to nanometer precision. Fully synthetic virus recognition materials have been shown to specifically bind their target virus down to picomolar concentrations. The shielding of natural enzymes allowed producing nanobiocatalysts functioning under harsh operational conditions...
April 26, 2017: Chimia
https://www.readbyqxmd.com/read/28446340/peptide-dendrimer-lipid-conjugates-as-dna-and-sirna-transfection-reagents-role-of-charge-distribution-across-generations
#13
Marc Heitz, Albert Kwok, Gabriela A Eggimann, Florian Hollfelder, Tamis Darbre, Jean-Louis Reymond
Transfection reagents are used to deliver DNA and siRNA into cells to achieve genetic manipulations, and may ultimately enable nonviral gene therapy. Progress in transfection reagents is limited by the fact that such reagents cannot be easily optimized due to their polymeric nature and/or difficult synthesis. We have developed a new class of well-defined and easily modifiable transfection reagents in the form of peptide dendrimers. These dendrimers self-assemble with DNA or siRNA and lipofectin to form nanoparticles which efficiently enter mammalian cells and liberate their nucleic acid cargo...
April 26, 2017: Chimia
https://www.readbyqxmd.com/read/28445646/spinning-hierarchical-gold-nanowire-microfibers-by-shear-alignment-and-intermolecular-self-assembly
#14
Beate Reiser, Dominik Gerstner, Lola Gonzalez-Garcia, Johannes H M Maurer, Ioannis Kanelidis, Tobias Kraus
Hierarchical structures lend strength to natural fibers made of soft nanoscale building blocks. Intermolecular interactions connect the components at different levels of hierarchy, distribute stresses, and guarantee structural integrity under load. Here, we show that synthetic ultrathin gold nanowires with interacting ligand shells can be spun into biomimetic, free-standing microfibers. A solution spinning process first aligns the wires, then lets their ligand shells interact, and finally converts them into a hierarchical superstructure...
April 26, 2017: ACS Nano
https://www.readbyqxmd.com/read/28445644/broadband-fluorescence-enhancement-with-self-assembled-silver-nanoparticle-optical-antennas
#15
Carolin Vietz, Izabela Kaminska, Maria Sanz Paz, Philip Tinnefeld, Guillermo P Acuna
Plasmonic structures are known to affect the fluorescence properties of dyes placed in close proximity. This effect has been exploited in combination with single-molecule techniques for several applications in the field of biosensing. Among these plasmonic structures, top-down zero-mode waveguides stand out due to their broadband capabilities. In contrast, optical antennas based on gold nanostructures exhibit fluorescence enhancement on a narrow fraction of the visible spectrum typically restricted to the red to near-infrared region...
April 28, 2017: ACS Nano
https://www.readbyqxmd.com/read/28445164/simple-and-scalable-preparation-of-master-mold-for-nanoimprint-lithography
#16
Yuri Yamada, Kota Ito, Atsushi Miura, Hideo Iizuka, Hiroaki Wakayama
Nanoimprint lithography (NIL) is one of the most prominent bottom-up techniques for duplicating nanostructures with a high throughput. However, fabrication of starting master mold commonly requires expensive equipment of top-down techniques, or additional steps to transfer the fabricated patterns from bottom-up methods. Here we demonstrate that a SiO2 nanostructure manufactured from a self-assembled block copolymer, polystyrene-b-polydimethylsiloxane (PS-b-PDMS), directly serves as a master mold for NIL without further modification...
May 19, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28445071/polymorphic-assembly-from-beveled-gold-triangular-nanoprisms
#17
Juyeong Kim, Xiaohui Song, Fei Ji, Binbin Luo, Nicole F Ice, Qipeng Liu, Qiao Zhang, Qian Chen
The shape anisotropy of nanoparticle building blocks is of critical importance in determining their packing symmetry and assembly directionality. While there has been extensive research on the effect of their overall geometric shapes, the importance of nanometer morphology details is not well-recognized or understood. Here we draw on shape-anisotropic gold triangular nanoprism building blocks synthesized based on a method we recently developed; besides the "large-scale" triangular prism shape (79.8 nm in side length and 22...
April 26, 2017: Nano Letters
https://www.readbyqxmd.com/read/28445035/characteristics-of-reduced-graphene-oxide-quantum-dots-for-a-flexible-memory-thin-film-transistor
#18
Yo-Han Kim, Eun Yeol Lee, Hyun Ho Lee, Tae Seok Seo
Reduced graphene oxide quantum dot (rGOQD) devices in formats of capacitor and thin film transistor (TFT) were demonstrated and examined as the first trial to achieve non-ambipolar channel property. In addition, through gold nanoparticles (Au NPs) layer embedded between the rGOQD active channel and dielectric layer, memory capacitor and TFT performances were realized by capacitance-voltage (C-V) hysteresis and gate program, erase, and reprogram biases. First, capacitor structure of the rGOQD memory device was constructed to examine memory charging effect featured in hysteretic C-V behavior with a 30 nm dielectric layer of crosslinked polyvinyl alcohol (PVA)...
April 26, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28444937/soluble-inorganic-nanoparticle-constructed-porous-coordination-frameworks-as-homogenized-heterogeneous-photocatalysts-for-suzuki-coupling-reaction-under-near-infrared-light
#19
Baodui Wang, Yuting Luo, Yong Peng, Weisheng Liu, Fengjuan Chen
Self-assembly has emerged as a promising method to control the structure and properties of ensembles of inorganic nanoparticles (NPs) for exploiting their collective effects. However, the rational assembly of inorganic NPs into soluble porous architectures as homogenized heterogeneous catalyst has been less studied. Here, we show that inorganic NPs can be used for the assembly of soluble porous coordination frameworks (PCFs) by atom-scale interfacial coordination-driven assembly strategy. Given large pore size, high dispersity in solution, strong absorption in the near-infrared range (NIR), and a long living electron-hole pair, the obtained soluble framework can serve as a platform for homogenize heterogeneous photocatalysts, which exhibited excellent activity, high apparent quantum efficiency, and recyclability to catalyze the noble metal free Suzuki coupling reaction under NIR light at room temperature...
April 26, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28444913/vesicle-origami-cuboid-phospholipid-vesicles-formed-by-template-free-self-assembly
#20
Frederik Neuhaus, Dennis Mueller, Radu Tanasescu, Sandor Balog, Takashi Ishikawa, Gerald Brezesinski, Andreas Zumbuehl
Phospholipid liposomes are archetypical self-assembled structures. To minimize the surface tension, the vesicles typically are spherical. Deciphering the bilayer code, the basic physical interactions between phospholipids would allow these molecules to be utilized as building blocks for novel, non-spherical structures. A 1,2-diamidophospholipid is presented that self-assembles into a cuboid structure. Owing to intermolecular hydrogen bonding, the bilayer membranes form an exceptionally tight subgel packing, leading to a maximization of flat structural elements and a minimization of any edges...
April 26, 2017: Angewandte Chemie
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