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Ayaka Sato, Yuya Ikeda, Koichi Yamaguchi, Varun Vohra
Facile detection and the identification of hazardous organic solvents are essential for ensuring global safety and avoiding harm to the environment caused by industrial wastes. Here, we present a simple method for the fabrication of silver-coated monodisperse polystyrene nanoparticle photonic structures that are embedded into a polydimethylsiloxane (PDMS) matrix. These hybrid materials exhibit a strong green iridescence with a reflectance peak at 550 nm that originates from the close-packed arrangement of the nanoparticles...
March 16, 2018: Nanomaterials
Joao Paulo Coelho, José Osío Barcina, Elena Junquera, Emilio Aicart, Gloria Tardajos, Sergio Gómez-Graña, Pablo Cruz-Gil, Cástor Salgado, Pablo Díaz-Núñez, Ovidio Peña-Rodríguez, Andrés Guerrero-Martínez
Amphiphilic nonionic ligands, synthesized with a fixed hydrophobic moiety formed by a thiolated alkyl chain and an aromatic ring, and with a hydrophilic tail composed of a variable number of oxyethylene units, were used to functionalize spherical gold nanoparticles (AuNPs) in water. Steady-state and time-resolved fluorescence measurements of the AuNPs in the presence of α-cyclodextrin (α-CD) revealed the formation of supramolecular complexes between the ligand and macrocycle at the surface of the nanocrystals...
March 16, 2018: Nanomaterials
Diego Jaramillo-Cano, Maud Formanek, Christos N Likos, Manuel Camargo
Star block-copolymers (SBCs) have been demonstrated to constitute self-assembling building blocks with specific softness, functionalization, shape and flexibility. In this work we study the behaviour of an isolated SBC under shear flow by means of particle-based multi-scale simulations. We systematically analyse the conformational properties of low-functionality stars as well as the formation of attractive patches on their corona as a function of the shear rate. We cover a wide range of system parameters, including functionality, amphiphilicity and solvent quality...
March 16, 2018: Journal of Physical Chemistry. B
Jejoong Yoo, Aleksei Aksimentiev
In contrast to ordinary polymers, the vast majority of biological macromolecules adopt highly ordered three-dimensional structures that define their functions. The key to folding of a biopolymer into a unique 3D structure or to an assembly of several biopolymers into a functional unit is a delicate balance between the attractive and repulsive forces that also makes such self-assembly reversible under physiological conditions. The all-atom molecular dynamics (MD) method has emerged as a powerful tool for studies of individual biomolecules and their functional assemblies, encompassing systems of ever increasing complexity...
March 16, 2018: Physical Chemistry Chemical Physics: PCCP
Zhili Wan, Yingen Sun, Lulu Ma, Feibai Zhou, Jian Guo, Song-Qing Hu, Xiao-Quan Yang
Nanofibrils from self-assembly of the naturally occurring saponin glycyrrhizic acid (GA) can be used to create an oil-in-water emulsion foam with long-term stability. Through a homogenization and aeration followed by a rapid cooling, stable emulsion foams can be produced from the mixtures of sunflower oil and saponin nanofibrils. At high temperature, the GA fibrils form a multilayer assembly at the interface, creating an interfacial fibrillar network to stabilize the oil droplets and air bubbles generated during homogenization...
March 16, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Varun Vohra, Francesco Galeotti, Umberto Giovanella, Wojciech Mroz, Mariacecilia Pasini, Chiara Botta
Push-coating is a green and extremely low-cost process in which only few microliters of conjugated polymer solutions are used to produce thin films using capillary forces. Here, we adapt this fabrication technique to replicate self-assembled nanoporous structures on green and red light-emitting conjugated polymer thin films. These films display ring-like photoluminescence and are successfully integrated into polymer light-emitting devices as emitting layers. At low applied voltages, the green-emitting devices exhibit electroluminescence from hexagonally arranged nanopixel arrays resulting from a stronger electric field in the thinner areas inside the pores...
March 16, 2018: ACS Applied Materials & Interfaces
Gaganpreet Kaur, Amanpreet Singh, Ajnesh Singh, Navneet Kaur, Narinder Singh
The unregulated use of organophosphates (OPs) as pesticides and toxic chemical warfare agents demands their continuous monitoring from a human health perspective. This study describes a fluorescence turn-on sensing assay for the selective quantification of OPs in aqueous medium. Metal complexes of two different Biginelli derivatives were processed in water through a reprecipitation technique. The engineered self-assembly of the pyridyl-2-cobalt complex (L1·Co(II)) was employed to selectively detect malathion while the pyridyl-4-cobalt complex (L2·Co(II)) could estimate azamethiphos fluorimetrically up to a detection limit of 9...
March 16, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Dongni Wu, Shuangying Zhang, Yuyuan Zhao, Ningjian Ao, Seeram Ramakrishna, Liumin He
RADA16-I (Ac-(RADA)4 -CONH2 ) is a widely investigated self-assembling peptide (SAP) in the biomedical field. It can undergo ordered self-assembly to form stable secondary structures, thereby further forming a nanofiber hydrogel. The modification of RADA16-I with functional peptide motifs has become a popular research topic. Researchers aim to exhibit particular biomedical signaling, and subsequently, further expand its applications. However, only a few fundamental reports are available on the influences of the peptide motifs on self-assembly mechanisms of designer functional RADA16-I SAPs...
March 16, 2018: Biomedical Materials
Valeria Messina, Mauro Valtieri, Mercedes Rubio, Mario Falchi, Francesca Mancini, Alfredo Mayor, Pietro Alano, Francesco Silvestrini
The gametocytes of Plasmodium falciparum , responsible for the transmission of this malaria parasite from humans to mosquitoes, accumulate and mature preferentially in the human bone marrow. In the 10 day long sexual development of P. falciparum , the immature gametocytes reach and localize in the extravascular compartment of this organ, in contact with several bone marrow stroma cell types, prior to traversing the endothelial lining and re-entering in circulation at maturity. To investigate the host parasite interplay underlying this still obscure process, we developed an in vitro tridimensional co-culture system in a Matrigel scaffold with P...
2018: Frontiers in Cellular and Infection Microbiology
Minghua Zheng, Jie Jiang, Xiao Zhang, Nan Wang, Kaihang Wang, Qiong Li, Tingting Li, Qingshan Lin, Yingbin Wang, Hai Yu, Ying Gu, Jun Zhang, Shaowei Li, Ningshao Xia
Hepatitis E virus (HEV) is associated with acute hepatitis disease. Numerous truncated HEV capsid proteins have been successfully expressed using different expression systems. Among these, p495, a protein truncated at its N- and C-termini by 111 and 54 amino acids (aa), respectively (HEV ORF2 aa 112-606) can self-assemble into T = 1 virus-like particles (VLPs) when expressed by insect cells. A shorter p239 (aa 368-606) protein is a particulate antigen that we have previously used in our commercialized HEV vaccine, Hecolin...
March 12, 2018: Vaccine
William D Piñeros, Beth A Lindquist, Ryan B Jadrich, Thomas M Truskett
Inverse design can be a useful strategy for discovering interactions that drive particles to spontaneously self-assemble into a desired structure. Here, we extend an inverse design methodology-relative entropy optimization-to determine isotropic interactions that promote assembly of targeted multicomponent phases, and we apply this extension to design interactions for a variety of binary crystals ranging from compact triangular and square architectures to highly open structures with dodecagonal and octadecagonal motifs...
March 14, 2018: Journal of Chemical Physics
Niloy Kundu, Debasis Banik, Nilmoni Sarkar
Amphiphiles are class of molecules which are known to assemble into a variety of nanostructures. The understanding and applications of self-assembled systems are based on what has been learned from biology. Among the vast number of self-assemblies, in this article, we have described the formation, characterization and dynamics of two important biologically inspired assemblies, vesicles and fibrils. Vesicles, which can be classified into several categories depending on the sizes and components, are of great interest due to their potential application in drug delivery and as nanoscale reactor...
March 15, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Yongbing Song, Teng Xie, Run Jiang, Zheng Wang, Yuhua Yin, Baohui Li, An-Chang Shi
The self-assembly behaviors of two block copolymers with the same chain length but different chain architectures (cyclic AB, linear ABA) in B-selective solvents are investigated using Monte Carlo simulations. A morphological transition sequence, from spherical micelles to cylindrical micelles, to vesicles and then to multicompartment vesicles, is observed for both copolymer systems when the interaction between the solvophobic A-block and the solvent is increased. In particular, toroidal micelles could be formed in triblock systems due to the presence of the bridging chains at the parameter region between cylindrical micelles and vesicles whereas disk-like micelles are formed in cyclic systems...
March 15, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Qianli Chu, Andrew J E Duncan, Giannis S Papaefstathiou, Tamara D Hamilton, Manza B J Atkinson, S V Santhana Mariappan, Leonard R MacGillivray
Enlargement of a self-assembled metal-organic rhomboid is achieved via the organic solid state. The solid-state synthesis of an elongated organic ligand was achieved by a template directed [2+2] photodimerization in a cocrystal. Initial cocrystals obtained of resorcinol template and reactant alkene afforded a 1:2 cocrystal with the alkene in a stacked yet photostable geometry. Cocrystallization performed in the presence of excess template resulted in 6:4 cocrystal composed of novel discrete 10-component hydrogen-bonded 'super-assemblies' wherein the alkenes undergo a head-to-head [2+2] photodimerization...
March 15, 2018: Journal of the American Chemical Society
Andrew J Olsen, Priya Katyal, Jennifer S Haghpanah, Matthew B Kubilius, Ruipeng Li, Nicole L Schnabel, Sean C O'Neill, Yao Wang, Min Dai, Navjot Singh, Raymond S Tu, Jin Kim Montclare
Recombinant methods have been used to engineer artificial protein triblock polymers comprised of two different self-assembling domains (SADs) bearing one elastin (E) flanked by two cartilage oligomeric matrix protein coiled-coil (C) domains to generate CEC. To understand how the two C domains improve small molecule recognition and the mechanical integrity of CEC, we have constructed CL44AECL44A, which bears an impaired CL44A domain that is unstructured as a negative control. The CEC triblock polymer demonstrates increased small molecule binding and ideal elastic behavior for hydrogel formation...
March 15, 2018: Biomacromolecules
Plansky Hoang, Jason Wang, Bruce R Conklin, Kevin E Healy, Zhen Ma
The creation of human induced pluripotent stem cells (hiPSCs) has provided an unprecedented opportunity to study tissue morphogenesis and organ development through 'organogenesis-in-a-dish'. Current approaches to cardiac organoid engineering rely on either direct cardiac differentiation from embryoid bodies (EBs) or generation of aligned cardiac tissues from predifferentiated cardiomyocytes from monolayer hiPSCs. To experimentally model early cardiac organogenesis in vitro, our protocol combines biomaterials-based cell patterning with stem cell organoid engineering...
April 2018: Nature Protocols
Yogesh Patil, Panayiotis Bilalis, Georgios Polymeropoulos, Sarah R Almahdali, Nikos Hadjichristidis, Valentin O Rodionov
A well-defined amphiphilic miktoarm polymer incorporating poly(vinylidene fluoride) (PVDF), polystyrene (PS), and poly(ethylene glycol) (PEG) blocks was synthesized via a combination of atom-transfer radical polymerization (ATRP), iodine transfer radical polymerization (ITP), and copper-catalyzed azide-alkyne cycloaddition (CuAAC). Morphology and self-assembly of this star polymer were examined in organic solvents and in water. The aggregates formed in water were found to possess unusual frustrated topology due to immiscibility of PS and PVDF...
March 15, 2018: Molecular Pharmaceutics
Zishen Wang, Qin'e Zhang, Shichuan Long, Yangxi Luo, Peikai Yu, Zhibing Tan, Jie Bai, Baihua Qu, Yang Yang, Jia Shi, Hua Zhou, Zong-Yuan Xiao, Wenjing Hong, Hua Bai
We apply direct ink writing for the three-dimensional (3D) printing of polyaniline/reduced graphene oxide (PANI/RGO) with PANI/GO gel as printable ink. The PANI/GO gel inks for 3D printing are prepared via self-assembly of PANI and GO in a blend solvent of N-methyl-2-pyrrolidinone and water, and offer both shaping capability, self-sustainability, and electrical conductivity after reduction of GO. Interdigitated electrodes are fabricated by using the PANI/GO ink in 3D printing, and a planar solid-state supercapacitor is constructed, which exhibits high performance with specific capacitance of 1329 mF cm-2...
March 15, 2018: ACS Applied Materials & Interfaces
Lu Han, Shunai Che
Triply periodic minimal surface structures and related geometries are widely identified in many natural systems, such as biological membranes and biophotonic structures in butterfly-wing scales. Inspired by their marvelous and highly symmetrical structures and optimized physical properties, these structures have sparked immense interest for creating novel materials by extracting the design from nature. Significant progress has been made to understand these biological structures and fabricate artificial materials by top-down and bottom-up approaches for numerous applications in chemistry and materials science...
March 15, 2018: Advanced Materials
Jiaqi Zhang, Zipeng Xing, Jiayi Cui, Zhenzi Li, Siyu Tan, Junwei Yin, Jinlong Zou, Qi Zhu, Wei Zhou
Herein, C,N co-doped porous TiO2 hollow sphere visible light photocatalysts were fabricated using biocompatible N-lauroyl-l-glutamic acid as a doped precursor and soft-template by a mild and facile self-assembly soft-template method, followed by calcination at 550 °C in air. The structure, morphology, and surface elemental composition were characterized in detail by X-ray diffraction, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, scanning electron microscopy, and transmission electron microscopy...
March 15, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
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