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https://www.readbyqxmd.com/read/28723407/nano-lipid-drug-conjugate-an-integrated-review
#1
REVIEW
Piya Adhikari, Paulami Pal, Anup Kr Das, Subhabrata Ray, Arpita Bhattacharjee, Bhaskar Mazumder
Lipid-drug conjugates (LDC), which may also be addressed as lipoidal prodrug, have the therapeutic actives chemically bound to a lipid moiety like fatty acids or phospholipids. Fabricated in nano-size, lipid-drug conjugate forms another breed of lipid nanoparticles. LDCs are prepared in order to increase the drug loading and hence prevent leakage of a highly polar drug from a lipophilic matrix. In turn, it assists to achieve active targeting of therapeutics with reduced side effect by altering the pharmacokinetic profile of the drug...
July 16, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28723181/mixed-self-assembled-aptamer-and-newly-designed-zwitterionic-peptide-as-antifouling-biosensing-interface-for-electrochemical-detection-of-alpha-fetoprotein
#2
Min Cui, Yu Wang, Mingxia Jiao, Silambarasan Jayachandran, Yumin Wu, Xiaojian Fan, Xiliang Luo
A sensitive and low-fouling aptasensor for alpha-fetoprotein (AFP) was developed based on mixed self-assembled aptamers and newly designed zwitterionic peptides, where densely immobilized peptides formed an antifouling layer to resist nonspecific protein adsorption, and sparsely attached aptamers acted as the recognizing layer to achieve target binding. The obtained biosensing interface responded to the target AFP with a strikingly selective and sensitive manner, exhibited excellent protein-resistant performance even in complex human serum solution, and showed promising feasibility for the quantitative analysis of AFP in real human serum samples...
April 28, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28723170/highly-efficient-multiple-anchored-fluorescent-probe-for-the-detection-of-aniline-vapor-based-on-synergistic-effect-chemical-reaction-and-pet
#3
Zinuo Jiao, Yu Zhang, Wei Xu, Xiangtao Zhang, Haibo Jiang, Pengcheng Wu, Yanyan Fu, Qingguo He, Huimin Cao, Jiangong Cheng
A multiple-anchored fluorescent probe ((((hexane-1,6-diylbis(2,7-bis(4-formyl)-phenyl)-9H-fluorine-9,9-diyl))-bis(hexane-6,1-diyl))-bis(9H-carbazole-9,3,6-triyl))-tetrakis(benzene-4,1-diyl))-tetraformyl-(8FP-2F) with eight aldehyde groups was designed and synthesized. The molecule has four branches and highly twisted structure. Furthermore, it tends to self-assemble into nanospheres, which is beneficial for gaseous analyte penetration and high fluorescence quantum efficiency. Among gaseous analytes, detection of aniline vapor is extraordinarily important in the control of environmental issues and human diseases...
May 26, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28723118/valence-states-modulation-strategy-for-picomole-level-assay-of-hg-2-in-drinking-and-environmental-water-by-directional-self-assembly-of-gold-nanorods
#4
Lu Chen, Linlin Lu, Sufan Wang, Yunsheng Xia
In this study, we present a valence states modulation strategy for picomole level assay of Hg(2+) using directional self-assembly of gold nanorods (AuNRs) as signal readout. Hg(2+) ions are first controllably reduced to Hg(+) ions by appropriate ascorbic acid, and the reduced Hg(+) ions react with the tips of the preadded AuNRs and form gold amalgam. Such Hg(+) decorated AuNRs then end-to-end self-assemble into one-dimensional architectures by the bridging effects of lysine based on the high affinity of NH2-Hg(+) interactions...
June 23, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28723113/an-inexpensive-single-use-carbon-based-sensor-for-the-rapid-and-early-detection-of-hydrocarbon-leaks
#5
H Bri Sebastian, Robert M Mayall, Roberto J Pilonieta, Steven L Bryant
A novel fabrication process for a single use, low-cost organic solvent sensor has been developed. The process is simple, and the materials are readily available. Carbon nanomaterials are self-assembled at a water/hexane interface, where the hexane phase contains dissolved paraffin wax. Upon the controlled evaporation of hexane, the paraffin wax precipitates, trapping the carbon nanoparticles at the surface in a paraffin wax backbone, realizing a carbon-nanoparticle-decorated film. The film is hydrophobic and highly electrically conductive...
June 23, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28723112/surfen-assembled-graphene-oxide-for-fluorescence-turn-on-detection-of-sulfated-glycosaminoglycans-in-biological-matrix
#6
Yen-Ting Wang, Wei-Lung Tseng
Sulfated glycosaminoglycans (GAGs) not only serve as a biomarker for mucopolysaccharidoses disease but also participate in various biological processes, such as blood clot medication (heparin) and signal transduction (heparan sulfate). However, few fluorescent sensors, such as 1,9-dimethylmethylene blue, have been developed for the detection of sulfated GAGs in the real world. Herein, we fabricated a surfen/few-layer graphene oxide (FLGO) nanocomplex for sensing sulfated GAGs in biological fluids. Surfen molecules are self-assembled onto the surface of FLGO through electrostatic attraction, and their fluorescence was then quenched by the creation of the FLGO-surfen complex (static quenching) and partially combined with the energy transfer from surfen to FLGO (dynamic quenching)...
June 23, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28723067/structural-and-spectroscopic-properties-of-assemblies-of-self-replicating-peptide-macrocycles
#7
Pim W J M Frederix, Julien Idé, Yigit Altay, Gaël Schaeffer, Mathieu Surin, David Beljonne, Anna S Bondarenko, Thomas L C Jansen, Sijbren Otto, Siewert J Marrink
Self-replication at the molecular level is often seen as essential to the early origins of life. Recently a mechanism of self-replication has been discovered in which replicator self-assembly drives the process. We have studied one of the examples of such self-assembling self-replicating molecules to a high level of structural detail using a combination of computational and spectroscopic techniques. Molecular Dynamics simulations of self-assembled stacks of peptide-derived replicators provide insights into the structural characteristics of the system and serve as the basis for semi-empirical calculations of the UV/Vis, circular dichroism (CD) and infrared (IR) absorption spectra that reflect the chiral organization and peptide secondary structure of the stacks...
July 19, 2017: ACS Nano
https://www.readbyqxmd.com/read/28722740/spectroscopic-imaging-studies-of-nanoscale-polarity-and-mass-transport-phenomena-in-self-assembled-organic-nanotubes
#8
Hao Xu, Shinobu Nagasaka, Naohiro Kameta, Mitsutoshi Masuda, Takashi Ito, Daniel A Higgins
Synthetic organic nanotubes self-assembled from bolaamphiphile surfactants are now being explored for use as drug delivery vehicles. In this work, several factors important to their implementation in drug delivery are explored. All experiments are performed with the nanotubes immersed in ethanol. First, Nile Red (NR) and a hydroxylated Nile Red derivative (NR-OH) are loaded into the nanotubes and spectroscopic fluorescence imaging methods are used to determine the apparent dielectric constant of their local environment...
July 19, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28722728/an-unprecedented-zn10o4-heteroadamantane-cage-containing-anilido-pyridinate-ligand-and-its-activity-for-ring-opening-polymerization-of-l-lactide-and-%C3%AE%C2%B5-caprolactone
#9
Ming-Tsz Chen, Chi-Tien Chen
(NPyC2OMe)8Zn10Et4(μ(4)-O)4 (1) has been synthesized in situ by hydrolysis of ZnEt2 in a one pot process and it was proved by applying X-ray structure analysis that the organozinc anilido-pyridinate moiety encapsulated the zinc oxide cluster, which demonstrated one self-assembled coordinate mode "Zn10O4". Moreover, the catalytic activity was investigated and good activity for l-lactide and ε-caprolactone ring opening polymerization was observed with both living and controllable properties.
July 19, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28722392/self-assembled-curved-macroporous-photonic-crystal-based-surfactant-detectors
#10
Chien-Fu Chiu, Hui-Ping Tsai, Ying-Chu Chen, Yi-Xuan He, Kun-Yi Andrew Lin, Hongta Yang
Surfactants are extensively used as detergents, dispersants, as well as emulsifiers. Thus, wastewater containing high-concentration surfactants discharged to the environment poses a serious threat to the ecosystem. Unfortunately, conventional detection methods for surfactants suffer from the use of sophisticated instruments, and cannot perform detections for various surfactants by a single analysis. The article reports the development of simple and sensitive surfactant detection using doctor blade coated three-dimensional curved macroporous photonic crystals on a cylindrical rod...
July 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28722277/in-situ-growth-and-wrapping-of-aminoanthraquinone-nanowires-within-3d-graphene-framework-as-high-performance-foldable-organic-cathode-for-lithium-ion-batteries
#11
Guanhui Yang, Fanxing Bu, Yanshan Huang, Yu Zhang, Imran Shakir, Yuxi Xu
Small conjugated carbonyl compounds are intriguing candidates of organic electrode materials because of their abundance, high theoretical capacity and adjustable molecular structure. However, their dissolution in aprotic electrolytes and poor conductivity eclipse them in terms of practical capacity, cycle life and rate capability. Herein, we report a foldable and binder-free nanocomposite electrode consisting of 2-aminoanthraquinone (AAQ) nanowires wrapping within three-dimensional (3D) graphene framework, which is prepared through antisolvent crystallization followed by a facile chemical reduction and self-assembly process...
July 19, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28722057/janus-particles-self-assembled-from-a-small-organic-atypical-asymmetric-gemini-surfactant
#12
Lei Tang, Jun Yang, Qinqin Yin, Linghui Yang, Deying Gong, Feng Qin, Junyang Liu, Qin Fan, Jiahong Li, Wenling Zhao, Weiyi Zhang, Jiyu Wang, Tao Zhu, Wensheng Zhang, Jin Liu
A series of atypical asymmetric gemini surfactants with an amphiphilic carbonate group (-O-CO-O-) have been prepared. Some of these compounds could self-assemble in water into gourd-shaped Janus particles (JPs). Initial results suggested that the formation of JPs was highly likely to be related to their atypical gemini surfactant structure. To our knowledge, this is the first report on JPs that are self-assembled from a single kind of small organic molecule. We believe that our results will be utilized in many fields...
July 19, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28722055/the-amyloid-architecture-provides-a-scaffold-for-enzyme-like-catalysts
#13
Z S Al-Garawi, B A McIntosh, D Neill-Hall, A A Hatimy, S M Sweet, M C Bagley, L C Serpell
Natural biological enzymes possess catalytic sites that are generally surrounded by a large three-dimensional scaffold. However, the proportion of the protein molecule that participates in the catalytic reaction is relatively small. The generation of artificial or miniature enzymes has long been a focus of research because enzyme mimetics can be produced with high activity at low cost. These enzymes aim to mimic the active sites without the additional architecture contributed by the protein chain. Previous work has shown that amyloidogenic peptides are able to self-assemble to create an active site that is capable of binding zinc and catalysing an esterase reaction...
July 19, 2017: Nanoscale
https://www.readbyqxmd.com/read/28722054/structural-complexity-induced-by-topology-change-in-hybrids-consisting-of-hexa-peri-hexabenzocoronene-and-polyhedral-oligomeric-silsesquioxane
#14
Meng-Yao Zhang, Sheng Zhou, Hong-Bing Pan, Jing Ping, Wei Zhang, Xing-He Fan, Zhihao Shen
Organic-inorganic hybrids with hexa-peri-hexabenzocoronene (HBC) and polyhedral oligomeric silsesquioxane (POSS) were designed and synthesized. The increase of the POSS content (or a change in topology) results in more complex self-assembled structures. This work provides a new approach for the design and synthesis of materials with sub-10 nm sizes.
July 19, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28721737/a-new-water-soluble-nano-micelle-through-self-assembly-pectin-curcumin-conjugates-preparation-characterization-and-anti-cancer-activity-evaluation
#15
Feng Bai, Jiajing Diao, Ying Wang, Shixin Sun, Hongmei Zhang, Yunyun Liu, Yanqing Wang, Jian Cao
Curcumin is a dominating active component of curcuma longa and has been studied widely because of its prominent biological activities. Extremely low aqueous solubility, stability and bioavailability of curcumin limits its application in the field of medicine. In this study, we developed pectin-curcumin (PEC-CCM) conjugates which could self-assemble water-soluble nano-micelles in aqueous solution. The structure of PEC-CCM conjugates was characterized by ultraviolet and visible spectra (UV-Vis), fluorescence spectra, Fourier transform infrared (FTIR) spectroscopy and 1H nuclear magnetic resonance (NMR) spectroscopy...
July 19, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28721731/self-assembled-injectable-peptide-hydrogels-capable-of-triggering-antitumor-immune-response
#16
Ruirui Xing, Shukun Li, Ning Zhang, Guizhi Shen, Helmuth Möhwald, Xuehai Yan
Self-assembled peptide hydrogels are particularly appealing for drug delivery, tissue engineering, and anti-tumor therapy due to various advantageous features including excellent biocompatibility and biodegradability, defined molecular and higher organized structures and easy availability. However, the poor mechanical and rheological properties of assembled peptide hydrogels cause difficulties in injection, thus limiting further applications. Herein, injectable peptide-based hydrogels with tunable mechanical and rheological properties were obtained by combination with a positively charged poly-peptide (poly-L-lysine, PLL)...
July 19, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28721045/synthesis-construction-and-evaluation-of-self-assembled-nano-bacitracin-a-as-an-efficient-antibacterial-agent-in-vitro-and-in-vivo
#17
Wei Hong, Xiang Gao, Peng Qiu, Jie Yang, Mingxi Qiao, Hong Shi, Dexian Zhang, Chunlian Tian, Shengli Niu, Mingchun Liu
Bacitracin A (BA) is an excellent polypeptide antibiotic that is active against gram-positive bacteria without triggering multidrug resistance. However, BA is inactive against gram-negative bacteria because of its inability to cross the outer membrane of these cells, and it has strong nephrotoxicity, thus limiting its clinical applications. Nanoantibiotics can effectively localize antibiotics to the periplasmic space of bacteria while decreasing the adverse effects of antibiotics. In this study, biodegradable hydrophobic copolymers of poly (d,l-lactide-co-glycolide) (PLGA) were attached to the N-termini of BA to design a novel class of self-assembled nano-bacitracin A (nano-BAs), and their potential as antibacterial agents was evaluated in vitro and in vivo...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28720896/nanoscale-control-of-amyloid-self-assembly-using-protein-phase-transfer-by-host-guest-chemistry
#18
Tae Su Choi, Hong Hee Lee, Young Ho Ko, Kwang Seob Jeong, Kimoon Kim, Hugh I Kim
Amyloid fibrils have recently been highlighted for their diverse applications as functional nanomaterials in modern chemistry. However, tight control to obtain a targeted fibril length with low heterogeneity has not been achieved because of the complicated nature of amyloid fibrillation. Herein, we demonstrate that fibril assemblies can be homogeneously manipulated with desired lengths from ~40 nm to ~10 μm by a phase transfer of amyloid proteins based on host-guest chemistry. We suggest that host-guest interactions with cucurbit[6]uril induce a phase transfer of amyloid proteins (human insulin, human islet amyloid polypeptide, hen egg lysozyme, and amyloid-β 1-40 & 1-42) from the soluble state to insoluble state when the amount of cucurbit[6]uril exceeds its solubility limit in solution...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28720097/a-versatile-papaya-mosaic-virus-papmv-vaccine-platform-based-on-sortase-mediated-antigen-coupling
#19
Ariane Thérien, Mikaël Bédard, Damien Carignan, Gervais Rioux, Louis Gauthier-Landry, Marie-Ève Laliberté-Gagné, Marilène Bolduc, Pierre Savard, Denis Leclerc
BACKGROUND: Flexuous rod-shaped nanoparticles made of the coat protein (CP) of papaya mosaic virus (PapMV) have been shown to trigger innate immunity through engagement of toll-like receptor 7 (TLR7). PapMV nanoparticles can also serve as a vaccine platform as they can increase the immune response to fused peptide antigens. Although this approach shows great potential, fusion of antigens directly to the CP open reading frame (ORF) is challenging because the fused peptides can alter the structure of the CP and its capacity to self assemble into nanoparticles-a property essential for triggering an efficient immune response to the peptide...
July 18, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28719882/antileishmanial-activity-and-tubulin-polymerization-inhibition-of-podophyllotoxin-derivatives-on-leishmania-infantum
#20
José Miguel Escudero-Martínez, Yolanda Pérez-Pertejo, Rosa M Reguera, María Ángeles Castro, María Victoria Rojo, Carolina Santiago, Andrés Abad, Pablo Anselmo García, José Luis López-Pérez, Arturo San Feliciano, Rafael Balaña-Fouce
Leishmania microtubules play an important role not only in cell division, but also in keeping the shape of the parasite and motility of its free-living stages. Microtubules result from the self-assembly of alpha and beta tubulins, two phylogenetically conserved and very abundant eukaryotic proteins in kinetoplastids. The colchicine binding domain has inspired the discovery and development of several drugs currently in clinical use against parasites. However, this domain is less conserved in kinetoplastids and may be selectively targeted by new compounds...
June 28, 2017: International Journal for Parasitology, Drugs and Drug Resistance
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