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Upper esophageal sphincter

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https://www.readbyqxmd.com/read/28110513/effect-of-methylnaltrexone-and-naloxone-on-esophageal-motor-function-in-man
#1
E Scarpellini, A Pauwels, R Vos, N Rommel, J Tack
BACKGROUND: Endogenous opioids (EO) acting on μ-opiod receptors in central and enteric nervous system (ENS) control gastrointestinal motility but it is still unclear whether EO in ENS may control esophageal function in man, thus we will study the effects of methylnaltrexone (MNTX), a peripherally selective, and naloxone (NA), a non-selective μ-opiod receptor antagonist, on esophageal motility in healthy subjects. METHODS: Fifteen HV (6 M; 34.1 ± 0.6 years; BMI: 22...
January 22, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27965007/effects-of-chin-down-maneuver-on-the-parameters-of-swallowing-function-following-esophagectomy-with-three-field-lymphadenectomy-examined-by-videofluoroscopy
#2
Yoshihiko Kumai, Naoya Yoshida, Yuta Kamenosono, Keigo Matsubara, Yasuhiro Samejima, Hideo Baba, Eiji Yumoto
OBJECTIVES: This study quantitatively determined the effect of the chin-down maneuver following esophagectomy with three-field lymphadenectomy (3FL) on pharyngeal residue, upper esophageal sphincter (UES) opening, and laryngeal closure. DESIGN: Prospective data were collected from a pharyngeal videofluoroscopic swallowing study. SETTING: Dysphagia clinics at the ENT Department of Kumamoto University Hospital. PARTICIPANTS: A total 14 patients (mean age, 65...
December 10, 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27935079/high-resolution-manometry-in-patients-with-idiopathic-inflammatory-myopathy-elevated-prevalence-of-esophageal-involvement-and-differences-according-to-autoantibody-status-and-clinical-subset
#3
Maria Casal-Dominguez, Iago Pinal-Fernandez, Marianela Mego, Anna Accarino, Lluis Jubany, Fernando Azpiroz, Albert Selva-O'Callaghan
INTRODUCTION: We studied the high-resolution manometry (HRM) findings in patients with dermatomyositis and polymyositis. METHODS: From 2008 to 2015, we performed a cross-sectional study of myositis patients. A survey of esophageal symptoms and a HRM were analyzed and compared among different clinical and serologic groups. RESULTS: Twenty-four (45%) of the 53 patients that were included in the study had manometric involvement that was not correlated with any esophageal symptom (P =0...
December 9, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27883179/evidence-that-an-internal-schema-adapts-swallowing-to-upper-airway-requirements
#4
Seng Mun Wong, Rickie J Domangue, Sidney Fels, Christy L Ludlow
KEY POINTS: To swallow food and liquid safely, airway protection is essential. Upward and forward movements of the hyoid and larynx in the neck during swallowing vary in magnitude between individuals. In healthy human adults, hyoid and laryngeal movements during swallowing were scaled by differences in initial upper airway area before swallowing. Individuals increased laryngeal elevation during swallowing in response to increased airway opening before swallowing. We show that when upper airway protection requirements change, individuals use an internal sensorimotor scaling system to adapt movements to maintain swallow safety...
November 24, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27862648/accuracy-of-the-air-flow-sphincter-locator-system-in-identifying-the-lower-esophageal-sphincter-for-placement-of-ph-catheters
#5
Joan W Chen, Jason R Baker, Jessica M Compton, Mark McDermott, Joel H Rubenstein
The Air Flow Sphincter Locator (AFSL) is marketed as an alternative method to manometry for localizing the lower esophageal sphincter (LES) for pH probe placement. Such a system is desirable due to the additional time, cost, and discomfort associated with dual nasal intubation, but its accuracy has never been assessed. To assess the accuracy of the AFSL in localizing the LES. Fifty consecutive outpatients presenting for pH and manometry studies were included. The upper border of the LES was determined using HRM and the AFSL by two technicians independently...
November 9, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27833390/oropharyngeal-acid-reflux-and-motility-abnormalities-of-the-proximal-esophagus
#6
Sandro Passaretti, Giorgia Mazzoleni, Cristian Vailati, Pier Alberto Testoni
AIM: To investigate the relationship between pathological oropharyngeal (OP) acid exposure and esophageal motility in patients with extra-esophageal syndromes. METHODS: In this prospective study we enrolled consecutive outpatients with extra-esophageal symptoms suspected to be related to gastroesophageal reflux disease (GERD). We enrolled only patients with a reflux symptom index (RSI) score-higher than 13 and with previous lung, allergy and ear, nose and throat evaluations excluding other specific diagnoses...
October 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27825384/inhibiting-the-proton-pump-mechanisms-benefits-harms-and-questions
#7
Jeffrey K Aronson
Inhibition of the H(+)/K(+)-adenosine triphosphatase (the proton pump) is the final common mechanistic pathway in reducing gastric acid secretion pharmacologically. Proton pump inhibitors are widely used in upper gastrointestinal diseases, including gastric and duodenal ulcers, eradication of Helicobacter pylori in combination with antibiotics, gastroesophageal reflux disease, Zollinger-Ellison syndrome, eosinophilic esophagitis, and prevention of non-steroidal anti-inflammatory drug-induced peptic ulceration...
November 9, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27822944/swallowing-function-defined-by-videofluoroscopic-swallowing-studies-after-anterior-cervical-discectomy-and-fusion-a-prospective-study
#8
Si Hyun Kang, Don Kyu Kim, Kyung Mook Seo, Sang Yoon Lee, Seung Won Park, Yong Baeg Kim
This study evaluated factors related to swallowing dysfunction after anterior cervical discectomy and fusion (ACDF) using videofluoroscopic swallowing studies (VFSS). Preoperative and postoperative VFSSs were done with 5 mL diluted barium. Oral transit time, pharyngeal delay time, pharyngeal response time (PRT), and pharyngeal transit time were measured. Hyoid bone movement and upper esophageal sphincter (UES) diameter were measured serially. Thickness of prevertebral soft tissue was measured from digitized VFSS images...
December 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27785316/pharyngoesophageal-obstruction-on-the-killian-laimer-triangle-by-zenker-s-diverticulum-case-report-and-clinical-significance
#9
Tulio F Leite, Carlos A A Chagas, Lucas A S Pires, Rafael Cisne, Marcio A Babinski
Zenker's diverticulum is a form of esophageal and pharyngeal obstruction located at the Killian-Laimer triangle. It is relatively common in elderly man (seventh or eighth decade of life), and its pathophysiology is not completely understood, albeit theories regarding dysfunction of the upper esophageal sphincter were reported. The main symptoms are dysphagia and odynophagia, but it can complicate to aspiration and perforation of the pharyngeal pouch; also, it can be asymptomatic. Diagnosis is provided through a barium esophagogram...
December 2015: Gastroenterology Research
https://www.readbyqxmd.com/read/27784974/incidence-clinical-features-and-para-clinical-findings-of-achalasia-in-algeria-experience-of-25-years
#10
Amar Tebaibia, Mohammed Amine Boudjella, Djamel Boutarene, Farouk Benmediouni, Hakim Brahimi, Nadia Oumnia
AIM: To investigate the incidence of achalasia in Algeria and to determine its clinical and para-clinical profile. To evaluate the impact of continuing medical education (CME) on the incidence of this disease. METHODS: From 1990 to 2014, 1256 patients with achalasia were enrolled in this prospective study. A campaign of CME on diagnosis involving different regions of the country was conducted between 1999 and 2003. Annual incidence and prevalence were calculated by relating the number of diagnosed cases to 10(5) inhabitants...
October 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27775286/-cricopharyngeal-achalasia-diagnosis-and-therapeutic-alternatives
#11
P Rodríguez Iglesias, V Ibáñez Pradas, A Alamar Velázquez, I Ibáñez Alcañiz, M Couselo Jerez
INTRODUCTION: The cricopharyngeal achalasia is an esophageal motor disorder that entails a lack of relaxation of the upper esophageal sphincter. It is rare in children and its etiology is related to multiple factors. The symptoms are nonspecific and may be masked by other diseases. CLINICAL CASE: Report two infants with dysphagia and choking episodes. Upper gastrointestinal series confirmed cricopharyngeal achalasia. The first patient was treated with endoscopic dilatation, and did not require further therapies...
April 15, 2015: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/27759771/late-evaluation-of-patients-operated-for-gastroesophageal-reflux-disease-by-nissen-fundoplication
#12
Maxwel Capsy Boga Ribeiro, Amanda Bueno de Araújo, Juverson Alves Terra-Júnior, Eduardo Crema, Nelson Adami Andreollo
Background: Surgical treatment of GERD by Nissen fundoplication is effective and safe, providing good results in the control of the disease. However, some authors have questioned the efficacy of this procedure and few studies on the long-term outcomes are available in the literature, especially in Brazil. Aim: To evaluate patients operated for gastro-esophageal reflux disease, for at least 10 years, by Nissen fundoplication. Methods: Thirty-two patients were interviewed and underwent upper digestive endoscopy, esophageal manometry, 24 h pH monitoring and barium esophagogram, before and after Nissen fundoplication...
July 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/27665746/the-motility-of-esophageal-sphincters-during-liquid-and-solid-bolus-swallows-a-multicenter-normative-value-study-of-high-resolution-manometry-in-china
#13
X-L Xiang, A Wang, L Tu, M-Y Ke, Y-S Yang, B Jiang, L Lin, N Dai, S-S Zhang, L Tao, H Xu, X-M Liang, X-C Fang, Z-W Xia, X Wang, J-N Wu, M-F Wang, H-J Zhang, Y-F Fang, C Shen, J Wang, L-H Peng, W-Y Li, Z-F Wang, K Wang, N Liu, X-H Hou
BACKGROUND: It is gradually accepted that solid bolus swallow needs to be added to the procedure of manometry. The motility differences in the upper esophageal sphincter (UES) and lower esophageal sphincter (LES) were not well described. Sierra Scientific Instruments solid-state high-resolution manometry (HRM) system, the most popular HRM system in China, lacks the Chinese normative values for both liquid and solid bolus swallow parameters. METHODS: The esophageal HRM data of 88 healthy volunteers were analyzed...
January 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27634073/leg-raise-increases-pressure-in-lower-and-upper-esophageal-sphincter-among-patients-with-gastroesophageal-reflux-disease
#14
P Bitnar, J Stovicek, R Andel, J Arlt, M Arltova, M Smejkal, P Kolar, A Kobesova
The purpose of this study was to determine the relation between posturally increased intra-abdominal pressure and lower/upper esophageal sphincter pressure changes in patients with gastroesophageal reflux disease. We used high resolution manometry to measure pressure changes in lower and upper esophageal sphincter during bilateral leg rise. We also examined whether the rate of lower and upper esophageal sphincter pressure would increase during leg raise differentially in individuals with versus without normal resting pressure...
July 2016: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/27630010/the-impact-of-the-speed-of-food-intake-on-gastroesophageal-reflux-events-in-obese-female-patients
#15
Serhat Bor, Askin Erdogan, Berna Bayrakci, Esra Yildirim, Rukiye Vardar
Obesity increases the risk of gastroesophageal reflux disease (GERD). The majority of the reflux attacks occur postprandially. The influence of the speed of food intake on gastroesophageal reflux events is unclear in obese patients. To determine the influence of the speed of food intake on intraesophageal reflux events in obese patients with and without GERD. A total of 26 obese female patients were recruited. The patients underwent esophageal manometry to evaluate the upper limit of the lower esophageal sphincter and subsequently placement of a Multichannel intraluminal impedance-pH (MII-pH) catheter...
September 15, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27611827/effects-of-wearing-and-removing-dentures-on-oropharyngeal-motility-during-swallowing
#16
S Onodera, J Furuya, H Yamamoto, Y Tamada, H Kondo
Wearing dentures and dysphagia are common in older individuals; however, it is still unknown how dentures affect oral and pharyngeal swallowing. The purpose of this study was to reveal the effects of wearing and removing dentures on oropharyngeal movements during pharyngeal swallowing in the feeding sequence of solid food. Participants were 25 edentulous volunteers (nine men, 16 women; mean age 76·2 years) who wore complete dentures. The test food was minced agar jelly containing barium sulphate. Subjects were instructed to feed and swallow the test food with or without dentures during observation using videofluorography...
November 2016: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/27595503/mano-videoendoscopic-assessment-in-the-evaluation-of-the-pharyngeal-contraction-and-upper-esophageal-sphincter-function-in-dysphagic-patients
#17
Takehiro Karaho, Junko Nakajima, Tetsuya Satoh, Keisuke Kawahara, Takeshi Nakayama, Naoyuki Kohno
OBJECTIVE: Mano-videoendoscopy (MVE) is a manometry technique with endoscopic confirmation of the pressure catheter. This study aimed to investigate the possibility of replacing a videofluorographic swallowing study (VFSS) with MVE for the precise evaluation of the pharyngeal contraction and the upper esophageal sphincter (UES) function. METHODS: The data from 69 patients with dysphagia were retrospectively reviewed. All of the patients underwent both MVE and a VFSS for the evaluation of dysphagia...
August 29, 2016: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/27583413/laryngeal-elevation-velocity-and-aspiration-in-acute-ischemic-stroke-patients
#18
Jing Zhang, Yun Zhou, Na Wei, Bo Yang, Anxin Wang, Hai Zhou, Xingquan Zhao, Yongjun Wang, Liping Liu, Melody Ouyoung, Brenda Villegas, Michael Groher
OBJECTIVES: Aspiration after stroke has been associated with aspiration pneumonia, which contributes to increased mortality of stroke. Laryngeal elevation is a core mechanism for protection from aspiration. Few studies have explored the predictive value of laryngeal elevation velocity for aspiration after stroke. This study aimed to explore the ability of laryngeal elevation velocity to predict aspiration in patients with acute ischemic stroke. METHODS: This was a prospective cohort study that included consecutive acute ischemic stroke patients treated at a teaching hospital during a 10-month period...
2016: PloS One
https://www.readbyqxmd.com/read/27565155/pharyngeal-pressure-and-timing-during-bolus-transit
#19
Chelsea C Walczak, Corinne A Jones, Timothy M McCulloch
Determining intrabolus pressure (IBP) at the upper esophageal sphincter (UES) and in the esophagus has given compelling evidence that IBP can be a predictor for swallowing dysfunction. Studies have looked most superiorly at the low hypopharynx region but there has been no inquiry into what IBP measures throughout the entire pharynx can tell us. We present a study to describe the pressures within and surrounding the moving bolus throughout the pharynx and into the UES. Simultaneous high-resolution manometry (HRM) and videofluoroscopy were performed in ten healthy subjects swallowing ten 10 mL thin-liquid barium boluses...
August 26, 2016: Dysphagia
https://www.readbyqxmd.com/read/27534548/modulation-of-upper-esophageal-sphincter-ues-relaxation-and-opening-during-volume-swallowing
#20
Charles Cock, Corinne A Jones, Michael J Hammer, Taher I Omari, Timothy M McCulloch
UES opening occurs following cricopharyngeus deactivation and submental muscle contraction causing hyolaryngeal elevation and UES distraction. During impedance manometry, the inverse of impedance (admittance) can be used to measure bolus presence and infer UES opening. We hypothesized that the temporal relationship between UES relaxation, opening and hyolaryngeal elevation would change with increasing bolus volume. Simultaneous intramuscular cricopharyngeal (CP) electromyography (EMG), surface submental EMG (SM-EMG), and high-resolution impedance manometry were recorded in eight (aged 27 ± 7 years, 5 M) healthy volunteers, while swallowing 0...
August 17, 2016: Dysphagia
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