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Facet syndrome

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https://www.readbyqxmd.com/read/29781931/ultrasound-assessment-of-ice-ball-formation-by-cryoneurolysis-device-in-an-ex-vivo-model
#1
Adrian Kastler, Hannes Gruber, Elke Gizewski, Alexander Loizides
BACKGROUND AND OBJECTIVES: Real-time ice-ball formation during cryoneurolysis has sparsely been assessed with ultrasound (US). Cryoneurolysis in lower back pain syndrome represents a validated management option in cases of facet joint syndrome. Ultrasound may be a useful tool to perform facet joint cryodenervation. The objective of this study was to assess, ex vivo, the ability of US to assess the ice-ball formation of a cryoneurolysis device. METHODS: Ultrasound assessment of the ice-ball depiction was done using chicken muscle at 22°C in which several freezing cycles were performed with both 2...
May 17, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29753556/pharmacotherapy-for-postural-tachycardia-syndrome
#2
REVIEW
Amanda J Miller, Satish R Raj
Postural tachycardia syndrome (POTS) is a disorder characterized by the presence of orthostatic symptoms (including lightheadedness, palpitations, nausea, dyspnea, and tremulousness) as well as excessive upright tachycardia. POTS predominantly affects women of childbearing age. Treating POTS involves a multi-faceted approach using non-pharmacological and pharmacological interventions. There are no pharmacological treatments that are currently United States Food and Drug Administration (FDA) approved for POTS due to lack of randomized controlled trials...
May 4, 2018: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/29688529/personality-pathology-and-schizophrenia
#3
Erik Simonsen, Giles Newton-Howes
The interaction of personality pathology and schizophrenia has conceptually been a topic of considerable interest in psychiatry. Recent advances in taxonomy and assessment of relevance to the clinician and researcher is presented. Cluster A and avoidant personality disorders are regarded as risk factors or antecedents for the development of schizophrenia. Some features of borderline personality disorder may resemble schizophrenia. With both a hierarchical structure and symptom-focused classification systems, personality pathology and personality disorder comorbidities can be overlooked...
April 24, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29682022/radiofrequency-and-methylprednisolone-in-treatment-of-lower-back-pain-caused-by-facet-joint-syndrome-comparison-of-the-outcomes
#4
Dagistan Yasar, Okmen Korgun, Dagistan Emine
Introduction: In this trial we have discussed the outcomes of radiofrequency ablation and methylprednisolone treatment in cases diagnosed with facet syndrome; and effects of treatment modality on quality of life is evaluated by visual analogue scale and Oswestry Disability Index. Materials and Methods: This prospective, study was conducted with 100 patients with diagnosis of facet joint syndrome. Patients, benefited from diagnostic block, were separated into two groups, with 50 cases in each...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29681862/increased-o-glcnacylation-of-endothelial-nitric-oxide-synthase-compromises-the-anti-contractile-properties-of-perivascular-adipose-tissue-in-metabolic-syndrome
#5
Rafael M da Costa, Josiane F da Silva, Juliano V Alves, Thiago B Dias, Diane M Rassi, Luis V Garcia, Núbia de Souza Lobato, Rita C Tostes
Under physiological conditions, the perivascular adipose tissue (PVAT) negatively modulates vascular contractility. This property is lost in experimental and human obesity and in the metabolic syndrome, indicating that changes in PVAT function may contribute to vascular dysfunction associated with increased body weight and hyperglycemia. The O -linked β-N-acetylglucosamine ( O -GlcNAc) modification of proteins ( O -GlcNAcylation) is a unique posttranslational process that integrates glucose metabolism with intracellular protein activity...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29595648/clinical-application-of-the-sinus-tarsi-approach-in-the-treatment-of-intra-articular-calcaneal-fracture
#6
Qingting Meng, Qingxian Wang, Xirui Wu, Aqin Peng, Jincheng Yan
To observe the clinical outcome of the sinus tarsi approach in the operative treatment of intra-articular calcaneal fractures.Forty-nine intra-articular calcaneal fractures in 45 patients were managed surgically with sinus tarsi approach. The anatomical plate and compression bolts were applied in 14 feet. The anatomical plate and screws were applied in 35 feet. Maryland foot score system was used to evaluate the function of the hindfoot at the followup.The reduction of the posterior facet was graded as nearly anatomical (less than 2 mm articular displacement) in 46 feet (93...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29593042/vzv-orf63-protects-human-neuronal-and-keratinocyte-cell-lines-from-apoptosis-and-changes-its-localization-upon-apoptosis-induction
#7
Chelsea Gerada, Megan Steain, Brian P McSharry, Barry Slobedman, Allison Abendroth
There are many facets of varicella zoster virus (VZV) pathogenesis that are not fully understood, such as the mechanisms involved in the establishment of lifelong latency, reactivation and development of serious conditions such as post herpetic neuralgia (PHN). Virus-encoded modulation of apoptosis has been suggested to play an important role in these processes. VZV open reading frame (ORF) 63 has been shown to modulate apoptosis in a cell type specific manner, but the impact of ORF63 on cell death pathways has not been examined in isolation, in the context of human cells...
March 28, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29576469/pathogenesis-of-endometriosis-interaction-between-endocrine-and-inflammatory-pathways
#8
REVIEW
Bansari G Patel, Emily E Lenk, Dan I Lebovic, Yimin Shu, Jie Yu, Robert N Taylor
Despite an estimated prevalence of 11% in women and plausible historical descriptions dating back to the 17th century, the etiology of endometriosis remains poorly understood. Classical theories of the histological origins of endometriosis are reviewed below. Clinical presentations are variable, and signs and symptoms do not correlate well with the extent of disease. In this summary, we have attempted to synthesize the growing evidence that hormonal and immune factors conspire to activate a local inflammatory microenvironment that encourages endometriosis to persist and elaborate mediators of its two cardinal symptoms: pain and infertility...
February 14, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29573619/estrogen-the-necessary-evil-for-human-health-and-ways-to-tame-it
#9
REVIEW
Seema Patel, Ahmad Homaei, Akondi Butchi Raju, Biswa Ranjan Meher
Estrogen is a pivotal enzyme for survival and health in both genders, though their quantum, tropism, tissue-specific distribution, and receptor affinity varies with different phases of life. Converted from androgen via aromatase enzyme, this hormone is indispensable to glucose homeostasis, immune robustness, bone health, cardiovascular health, fertility, and neural functions. However, estrogen is at the center of almost all human pathologies as well-infectious, autoimmune, metabolic to degenerative. Both hypo and hyper level of estrogen has been linked to chronic and acute diseases...
June 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29570515/patient-reported-quality-of-life-in-the-highest-functioning-patients-with-treacher-collins-syndrome
#10
Jéssica Pereira de Oliveira, Fernando Felipe Lodovichi, Miria Benincasa Gomes, Eda Marconi Custódio, Rafael Denadai, Cesar Augusto Raposo-Amaral, Enrico Ghizoni, Cassio Eduardo Raposo-Amaral
BACKGROUND: Treacher Collins syndrome has a wide variation of clinical presentation, including airway obstruction and hearing loss. The objective of this study was to assess patient-rated quality of life in Treacher Collins syndrome, who received multidisciplinary treatment at a specialized craniofacial hospital, and to compare their quality of life with a control sample. METHODS: Treacher Collins patients under treatment in a multidisciplinary setting were assessed with the World Health Organization Quality of Life (WHOQOL-100) questionnaire...
March 22, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29530929/separate-roles-for-med12-and-wnt-signaling-in-regulation-of-oxytocin-expression
#11
Emma D Spikol, Eric Glasgow
Transcriptional control of oxytocinergic cell development influences social, sexual, and appetite related behaviors and is implicated in disorders such as autism and Prader-Willi syndrome. Mediator 12 (Med12) is a transcriptional coactivator required for multiple facets of brain development including subsets of serotonergic and dopaminergic neurons. We surveyed hormone gene expression within the hypothalamo-pituitary axis of med12 mutant zebrafish embryos with a focus on oxytocin ( oxt ) expression. Some transcripts, such as oxt , vasopressin ( avp ) and corticotrophin releasing hormone ( crh ) are undetectable in the med12 mutant, while others are upregulated or downregulated to varying degrees...
March 28, 2018: Biology Open
https://www.readbyqxmd.com/read/29492144/bow-hunter-s-syndrome-in-a-patient-with-a-right-hypoplastic-vertebral-artery-and-a-dynamically-compressible-left-vertebral-artery
#12
David Z Cai, Ryan P Roach, John P Weaver, Gerald T McGillicuddy, Zachary M Mansell, Jonathan P Eskander, Mark S Eskander
This is a case report of a 48-year-old man with multiple transient ischemic attacks and a known hypoplastic right vertebral artery (VA) who presented after a syncopal event while turning his head to the left. The objective of this study is to demonstrate the necessity of proper diagnosis and management of cerebrovascular pathology including imaging and surgical intervention in patients with known anatomical anomalies. This study was conducted at Massachusetts, United States of America. Our patient's history was significant for a hypoplastic right VA and a stenotic segment of the right VA at the C3-C4 junction...
January 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29486812/rheumatism-and-chronic-fatigue-the-two-facets-of-post-chikungunya-disease-the-telechik-cohort-study-on-reunion-island
#13
A Duvignaud, A Fianu, A Bertolotti, J Jaubert, A Michault, P Poubeau, A Fred, M Méchain, B-A Gaüzère, F Favier, D Malvy, P Gérardin
Prolonged fatigue is increasingly reported among chikungunya virus (CHIKV)-infected populations. We investigated the relationships between CHIKV exposure, long-lasting rheumatic musculoskeletal pain (LRMSP) and chronic fatigue. 1094 participants (512 CHIKV seropositive and 582 seronegative) of the TELECHIK population-based cohort were analysed considering the duration of the manifestations throughout an average 2-year follow-up. Weighted prevalence rates and prevalence ratios for LRMSP, idiopathic chronic fatigue (ICF), and chronic fatigue syndrome (CFS)-like illness, both latter syndromes adapted from Centers for Disease Control (CDC)-1994/Fukuda criteria, were compared...
April 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29475453/whole-transcriptome-analysis-reveals-differential-gene-expression-profile-reflecting-macrophage-polarization-in-response-to-influenza-a-h5n1-virus-infection
#14
Na Zhang, Yun-Juan Bao, Amy Hin-Yan Tong, Scott Zuyderduyn, Gary D Bader, J S Malik Peiris, Si Lok, Suki Man-Yan Lee
BACKGROUND: Avian influenza A H5N1 virus can cause lethal disease in humans. The virus can trigger severe pneumonia and lead to acute respiratory distress syndrome. Data from clinical, in vitro and in vivo suggest that virus-induced cytokine dysregulation could be a contributory factor to the pathogenesis of human H5N1 disease. However, the precise mechanism of H5N1 infection eliciting the unique host response are still not well understood. METHODS: To obtain a better understanding of the molecular events at the earliest time points, we used RNA-Seq to quantify and compare the host mRNA and miRNA transcriptomes induced by the highly pathogenic influenza A H5N1 (A/Vietnam/3212/04) or low virulent H1N1 (A/Hong Kong/54/98) viruses in human monocyte-derived macrophages at 1-, 3-, and 6-h post infection...
February 23, 2018: BMC Medical Genomics
https://www.readbyqxmd.com/read/29462979/mindfulness-is-associated-with-the-metabolic-syndrome-among-individuals-with-a-depressive-symptomatology
#15
Erika Guyot, Julia Baudry, Serge Hercberg, Pilar Galan, Emmanuelle Kesse-Guyot, Sandrine Péneau
The Metabolic Syndrome (MetS) is a major public health burden. Dispositional mindfulness has recently been associated with eating disorders, being overweight, and could therefore be associated with the MetS. We aimed to examine in a cross-sectional design the relationship between mindfulness, the MetS, and its risk factors in a large sample of the adult general population and the influence of depressive symptomatology on this association. Adults participating in the NutriNet-Santé study who had completed the Five Facets Mindfulness Questionnaire and attended a clinical and biological examination were available for inclusion...
February 17, 2018: Nutrients
https://www.readbyqxmd.com/read/29406827/pyoderma-gangrenosum-a-review-of-pathogenesis-and-treatment
#16
Christine Ahn, Deborah Negus, William Huang
Pyoderma gangrenosum (PG) is a complex neutrophilic dermatosis that can occur as an idiopathic disease, in association with systemic conditions such as inflammatory bowel disease, as part of an inherited inflammatory syndrome. It can be challenging to treat, as it occurs in a wide variety of clinical settings and there is a lack of a standardized treatment approach. The main limitations to treatment have been an incomplete understanding of the pathogenesis. However, recent advances have been made in understanding the pathogenesis of this condition, and PG is now considered an autoinflammatory disease process...
March 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29380312/generation-of-maternal-obesity-models-in-studies-of-developmental-programming-in-rodents
#17
Paul D Taylor, Phillippa A Matthews, Imran Y Khan, Douglas Rees, Nozomi Itani, Lucilla Poston
Mother-child cohort studies have established that both pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) are independently associated with cardio-metabolic risk factors in juvenile and adult offspring, including systolic and diastolic blood pressure. In rodent studies maternal obesity confers many facets of the metabolic syndrome including a persistent sympathy-excitatory hyperresponsiveness and hypertension acquired in the early stages of development. Insight from these animal models raises the possibility that early life exposure to the nutritional and hormonal environment of obesity in pregnancy in humans may lead to early onset of metabolic syndrome and/or essential hypertension...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29343043/mandibular-pain-an-uncommon-radiation-for-cervical-facet-joint-syndrome
#18
Emanuele Piraccini, Helen Byrne, Morena Calli, Giovanni Musetti, Daniele Bellantonio, Ruggero M Corso, Stefano Maitan
No abstract text is available yet for this article.
January 17, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29315377/reply-non-freezing-cold-injury-a-multi-faceted-syndrome
#19
Tom A Vale, Mkael Symmonds, Michael Polydefkis, Kelly Byrnes, Andrew S C Rice, Andreas C Themistocleous, David L H Bennett
No abstract text is available yet for this article.
February 1, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29315359/non-freezing-cold-injury-a-multi-faceted-syndrome
#20
Clare M Eglin, Hugh Montgomery, Michael J Tipton
No abstract text is available yet for this article.
February 1, 2018: Brain: a Journal of Neurology
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