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https://www.readbyqxmd.com/read/28652965/a-protocol-for-manual-segmentation-of-medial-temporal-lobe-subregions-in-7%C3%A2-tesla-mri
#1
D Berron, P Vieweg, A Hochkeppler, J B Pluta, S-L Ding, A Maass, A Luther, L Xie, S R Das, D A Wolk, T Wolbers, P A Yushkevich, E Düzel, L E M Wisse
Recent advances in MRI and increasing knowledge on the characterization and anatomical variability of medial temporal lobe (MTL) anatomy have paved the way for more specific subdivisions of the MTL in humans. In addition, recent studies suggest that early changes in many neurodegenerative and neuropsychiatric diseases are better detected in smaller subregions of the MTL rather than with whole structure analyses. Here, we developed a new protocol using 7 Tesla (T) MRI incorporating novel anatomical findings for the manual segmentation of entorhinal cortex (ErC), perirhinal cortex (PrC; divided into area 35 and 36), parahippocampal cortex (PhC), and hippocampus; which includes the subfields subiculum (Sub), CA1, CA2, as well as CA3 and dentate gyrus (DG) which are separated by the endfolial pathway covering most of the long axis of the hippocampus...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28651650/ethics-review-of-studies-during-public-health-emergencies-the-experience-of-the-who-ethics-review-committee-during-the-ebola-virus-disease-epidemic
#2
Emilie Alirol, Annette C Kuesel, Maria Magdalena Guraiib, Vânia Dela Fuente-Núñez, Abha Saxena, Melba F Gomes
BACKGROUND: Between 2013 and 2016, West Africa experienced the largest ever outbreak of Ebola Virus Disease. In the absence of registered treatments or vaccines to control this lethal disease, the World Health Organization coordinated and supported research to expedite identification of interventions that could control the outbreak and improve future control efforts. Consequently, the World Health Organization Research Ethics Review Committee (WHO-ERC) was heavily involved in reviews and ethics discussions...
June 26, 2017: BMC Medical Ethics
https://www.readbyqxmd.com/read/28651227/double-cystic-duct-preoperatively-diagnosed-and-successfully-treated-with-laparoscopic-cholecystectomy-a-case-report
#3
Atsushi Fujii, Masatsugu Hiraki, Noriyuki Egawa, Hiroshi Kono, Takao Ide, Junichi Nojiri, Junji Ueda, Hiroyuki Irie, Hirokazu Noshiro
INTRODUCTION: A single gallbladder with a double cystic duct is a very rare finding. In addition, few cases with this rare condition are preoperatively diagnosed. However, the preoperative confirmation or suspicion of this rare condition could facilitate safe laparoscopic cholecystectomy, which is a minimally invasive therapeutic modality for gallbladder disease. We herein present a case of gallstone disease in a patient with a double cystic duct who was preoperatively diagnosed and successfully treated with laparoscopic cholecystectomy...
June 13, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28643322/difficulties-in-funding-of-va-ecmo-therapy-for-patients-with-severe-accidental-hypothermia
#4
Sylweriusz Kosiński, Tomasz Darocha, Anna Jarosz, Aleksandra Czerw, Paweł Podsiadło, Tomasz Sanak, Robert Gałązkowski, Jacek Piątek, Janusz Konstanty-Kalandyk, Mirosław Ziętkiewicz, Krzysztof Kusza, Łukasz J Krzych, Rafał Drwiła
BACKGROUND: Severe accidental hypothermia is defined as a core temperature below 28 Celsius degrees. Within the last years, the issue of accidental hypothermia and accompanying cardiac arrest has been broadly discussed and European Resuscitation Council (ERC) Guidelines underline the importance of Extracorporeal Rewarming (ECR) in treatment of severely hypothermic victims. The study aimed to evaluate the actual costs of ECR with VA-ECMO and of further management in the Intensive Care Unit of patients admitted to the Severe Accidental Hypothermia Centre in Cracow, Poland...
2017: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/28629343/comparative-effectiveness-research-what-to-do-when-experts-disagree-about-risks
#5
Reidar K Lie, Francis K L Chan, Christine Grady, Vincent H Ng, David Wendler
BACKGROUND: Ethical issues related to comparative effectiveness research, or research that compares existing standards of care, have recently received considerable attention. In this paper we focus on how Ethics Review Committees (ERCs) should evaluate the risks of comparative effectiveness research. MAIN TEXT: We discuss what has been a prominent focus in the debate about comparative effectiveness research, namely that it is justified when "nothing is known" about the comparative effectiveness of the available alternatives...
June 19, 2017: BMC Medical Ethics
https://www.readbyqxmd.com/read/28626827/the-effect-of-rapid-privatisation-on-mortality-in-mono-industrial-towns-in-post-soviet-russia-a-retrospective-cohort-study
#6
Aytalina Azarova, Darja Irdam, Alexi Gugushvili, Mihaly Fazekas, Gábor Scheiring, Pia Horvat, Denes Stefler, Irina Kolesnikova, Vladimir Popov, Ivan Szelenyi, David Stuckler, Michael Marmot, Michael Murphy, Martin McKee, Martin Bobak, Lawrence King
BACKGROUND: Population-level data suggest that economic disruptions in the early 1990s increased working-age male mortality in post-Soviet countries. This study uses individual-level data, using an indirect estimation method, to test the hypothesis that fast privatisation increased mortality in Russia. METHODS: In this retrospective cohort study, we surveyed surviving relatives of individuals who lived through the post-communist transition to retrieve demographic and socioeconomic characteristics of their parents, siblings, and male partners...
May 2017: Lancet. Public Health
https://www.readbyqxmd.com/read/28622530/brain-network-dynamics-in-the-human-articulatory-loop
#7
Masaaki Nishida, Anna Korzeniewska, Nathan E Crone, Goichiro Toyoda, Yasuo Nakai, Noa Ofen, Erik C Brown, Eishi Asano
OBJECTIVE: The articulatory loop is a fundamental component of language function, involved in the short-term buffer of auditory information followed by its vocal reproduction. We characterized the network dynamics of the human articulatory loop, using invasive recording and stimulation. METHODS: We measured high-gamma activity70-110 Hz recorded intracranially when patients with epilepsy either only listened to, or listened to and then reproduced two successive tones by humming...
May 17, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28597104/-upper-abdominal-pain-nausea-and-vomiting-in-a-63-year-old-woman
#8
S Schwarzer, K Rapis
We present a case of myotonic dystrophy type I and its complications including cholangitis and cardiac arrhythmias. The therapy options focus on the consequences of the disease and result in an endoscopic retrograde cholangiography (ERC) and implantation of an implantable cardioverter-defibrillator (ICD). Myotonic dystrophy is a disease which results in a loss of smooth and skeletal muscle cells leading to multiple consequences such as gastrointestinal symptoms and cardiac manifestations.
June 8, 2017: Der Internist
https://www.readbyqxmd.com/read/28586081/bed%C3%A3-mning-av-neuro%C3%A2-logisk-prognos-efter-hj%C3%A3-rtstopp-uppdaterade-rekommendationer-fr%C3%A3-n-svenska-hlr-r%C3%A3-dets-expertgrupp
#9
Christian Rylander, Hans Friberg, Elna-Marie Larsson, Lars Johan Liedholm, Sten Rubertsson, Tobias Cronberg
Assessment of neurologic prognosis after cardiac arrest. Updated recommendations from the Swedish CPR Council Expert Group European Resuscitation Council (ERC) issued updated guidelines for postresuscitation care in 2015. This paper provides updated Swedish recommendations for neurological prognostication of patients remaining unconscious after cardiac arrest (CA). The prognostication should be based on independent methods; clinical and neurophysiological examinations, imaging and biomarkers. It should not be performed earlier than three days after CA and any influence from sedatives must be negligible...
June 2, 2017: Läkartidningen
https://www.readbyqxmd.com/read/28585854/abordaje-nutricional-del-paciente-con-diabetes-mellitus-e-insuficiencia-renal-cr%C3%A3-nica-a-prop%C3%A3-sito-de-un-caso
#10
Beatriz Torres Torres, Olatz Izaola Jáuregu, Daniel A De Luis Román
La prevención y el tratamiento de la enfermedad renal crónica (ERC) en pacientes con diabetes ha sido un tema de gran interés a lo largo de los años. Para conseguir un adecuado control glucémico, una función renal estable y una reducción del riesgo cardiovascular, es fundamental un correcto aporte de hidratos de carbono, lípidos y proteínas. Las medidas dietéticas realizadas se irán modificando a lo largo de la evolución de la ERC. La malnutrición energético-proteica es muy frecuente en pacientes con ERC y diabetes y es un importante predictor de morbimortalidad...
May 8, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28545474/a-retrospective-study-to-assess-the-evaluation-of-living-related-kidney-donors-and-their-outcomes-following-nephrectomy-at-kenyatta-national-hospital
#11
A Muturi, V Kotecha, S Kanyi
BACKGROUND: Kidney transplantation is the renal replacement therapy of choice for end stage renal disease. To ensure safety regular audit of the donation process is necessary. The aim of this study was to assess the evaluation of potential living related kidney donors and document their outcomes following nephrectomy. METHODS: This was a retrospective descriptive study involving all living related kidney donors seen at Kenyatta National Hospital (KNH) renal unit from 2010 to 2014...
May 25, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28541549/cognitive-development-in-children-up-to-age-11-years-born-after-art-a-longitudinal-cohort-study
#12
Anna Barbuscia, Melinda C Mills
STUDY QUESTION: How does the cognitive development of children conceived after ART (IVF and ICSI) - measured as cognitive skills at age 3, 5, 7 and 11 years - differ over time from those born after natural conception (NC)? SUMMARY ANSWER: Improved measures of cognitive development up to age 5 years were recorded in children conceived with ART compared to NC, which attenuates by 11 years, with ART children still scoring slightly better than NC children. WHAT IS KNOWN ALREADY: Results on the cognitive outcomes of children conceived after ART have been highly contradictory...
May 24, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28507330/flatbed-epi-relief-contrast-cellular-monitoring-system-for-stable-cell-culture
#13
Tatsuya Osaki, Tatsuto Kageyama, Yuka Shimazu, Dina Mysnikova, Shintaro Takahashi, Shinichi Takimoto, Junji Fukuda
Consistent cell preparation is a fundamental preliminary step for understanding complex cellular mechanisms in various cell-based research fields, including basic cell biology, cancer research, and tissue engineering. However, certain elusive factors, such as cellular de-differentiation and contamination with mycoplasma or other types of cells, have compromised the reproducibility and reliability of cell-based approaches. Here, we propose an epi relief-contrast cellular monitoring system (eRC-CMS) that allows images of cells in a typical culture plate to be acquired, stored, and analysed for daily cell quality control...
May 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28501058/limited-quality-evidence-suggests-that-early-caries-experience-at-age-6-years-may-predict-low-oral-health-related-quality-of-life-at-age-10%C3%A2-years
#14
Vinodh Bhoopathi, Marisol Tellez, Sungwoo Lim
ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Early Caries Predicts Low Oral Health-Related Quality of Life at a Later Age. Kragt L, van der Tas JT, Moll HA, Elfrink ME, Jaddoe VW, Wolvius EB, Ongkosuwito EM. Caries Res. 2016; 50(5):471-9. SOURCE OF FUNDING: This study was funded by (1) the Erasmus Medical Center, Rotterdam, the Erasmus University, Rotterdam, (2) the Netherlands Organization for Health Research and Development, (3) an unrestricted grant from GABA, Therwil, Switzerland, (4) the Netherlands Organization for Health Research and Development (VIDI 016...
June 2017: Journal of Evidence-based Dental Practice
https://www.readbyqxmd.com/read/28487877/preoperative-fasting-among-adult-patients-for-elective-surgery-in-a-kenyan-referral-hospital
#15
George Njoroge, Lucy Kivuti-Bitok, Samuel Kimani
Background. Preoperative fasting (POF) is physiologically and precautionary important during anesthesia and surgery. POF from midnight has been practiced despite the recommended shorter practice. Objective. Assessing preoperative fasting among adult patients scheduled for elective surgery at Kenyatta National Hospital (KNH). Methods. A descriptive cross-sectional study involving 65 surgical patients. A questionnaire of mixed questions on demographics, reasons, source of instructions, opinion on instructions, time, premedication practices, outcome, and complains on NPO was used...
2017: International Scholarly Research Notices
https://www.readbyqxmd.com/read/28481037/regional-quantification-of-myocardial-mechanics-in-rat-using-3d-cine-dense-cardiovascular-magnetic-resonance
#16
Xiaoyan Zhang, Zhan-Qiu Liu, Dara Singh, Gregory J Wehner, David K Powell, Kenneth S Campbell, Brandon K Fornwalt, Jonathan F Wenk
Rat models have assumed an increasingly important role in cardiac research. However, a detailed profile of regional cardiac mechanics, such as strains and torsion, is lacking for rats. We hypothesized that healthy rat left ventricles (LVs) exhibit regional differences in cardiac mechanics, which are part of normal function. In this study, images of the LV were obtained with 3D cine displacement encoding with stimulated echoes (DENSE) cardiovascular magnetic resonance in 10 healthy rats. To evaluate regional cardiac mechanics, the LV was divided into basal, mid-ventricular, and apical regions...
May 8, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28479341/towards-intrinsic-r2-imaging-in-the-prostate-at-3-and-7tesla
#17
Mariska P Luttje, Laurens D van Buuren, Peter R Luijten, Marco van Vulpen, Uulke A van der Heide, Dennis W J Klomp
PURPOSE: Hypoxia is an important marker for resistance to therapy. In this study, we quantify the macroscopic effects of R2* mapping in prostate cancer patients incorporating susceptibility matching and field strengths effects. MATERIALS AND METHODS: 91 patients were scanned without endorectal coil (ERC) at 3T. Only when rectal gas was absent, data was included for analysis. Another group of 10 patients was scanned using a susceptibility matched ERC. To assess the residual contamination of R2 and macroscopic field non-uniformities, a group of 10 patients underwent ultra-high resolution 7T MRI...
May 4, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28465140/development-and-validation-of-a-novel-paediatric-weight-estimation-equation-in-multinational-cohorts-of-sick-children
#18
Lindsey McVey, David Young, Jessie Hulst, Sarah Bradley, Adrian Raudaschl, Thomais Karagiozoglou, Efstratia Daskalou, Vincent Choudhery, Isobel Macleod, Koen Joosten, Neil Spenceley, Konstantinos Gerasimidis
AIM: In sick children who are unable to be weighed estimation of weight is often required, but the routinely used equations lack accuracy and precision. This study aimed to develop a novel equation (Children's European Estimator of Weight-CEEW) using measurements of mid-upper arm circumference (MUAC) and other predictors in multinational groups of sick children in Europe. METHODS: Weight estimation equations were developed in 2086 children from the UK, Greece and the Netherlands, using a combination of demographics, MUAC and height measurements...
April 29, 2017: Resuscitation
https://www.readbyqxmd.com/read/28461210/tracking-and-tracing-tobacco-products-in-kenya
#19
Hana Ross
This report evaluates the effectiveness of various measures to control the size of illicit cigarette trade in Kenya. It is based on a literature review, a review of conference proceedings/materials, online searches, and analyses of data from the National Statistical Office of Kenya, ERC, and Euromonitor. I used both published and grey literature, official government reports, and online news articles. In response to the presence of illicit cigarettes in the market in the early 2000s, Kenya adopted numerous measures to reduce tobacco tax evasion, with varying degrees of success...
April 29, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28451776/acetylsalicylic-acid-tris-hydroxymethyl-aminomethane-reduces-colon-mucosal-damage-without-causing-gastric-side-effects-in-a-rat-model-of-colitis
#20
Gabriella Varga, Melinda Ugocsai, Petra Hartmann, Norbert Lajkó, Réka Molnár, Szilárd Szűcs, Dávid Kurszán Jász, Dániel Érces, Miklós Ghyczy, Gábor Tóth, Mihály Boros
BACKGROUND: We have developed a novel compound from acetylsalicylic acid (ASA) and 2-amino-2-(hydroxymethyl)-1,3-propanediol (Tris) precursors with ASA-like anti-inflammatory efficacy and reduced the mucosa-damaging side-effects. Our aim was to examine local and remote consequences of ASA-Tris administration in 2-,4-,6-trinitrobenzene-sulfonic acid (TNBS)-induced colitis as compared to ASA or mesalamine (5-aminosalicylate) treatment. METHODS: Sprague-Dawley rats were randomized to five groups (n = 6, each), and TNBS enemas were performed...
April 27, 2017: Inflammopharmacology
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