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https://www.readbyqxmd.com/read/29321048/danish-first-aid-books-compliance-with-the-new-evidence-based-non-resuscitative-first-aid-guidelines
#1
Theo Walther Jensen, Thea Palsgaard Møller, Søren Viereck, Jens Roland, Thomas Egesborg Pedersen, Freddy K Lippert
BACKGROUND: The European Resuscitation Council (ERC) released new guidelines on resuscitation in 2015. For the first time, the guidelines included a separate chapter on first aid for laypersons. We analysed the current major Danish national first aid books to identify potential inconsistencies between the current books and the new evidence-based first aid guidelines. METHODS: We identified first aid books from all the first aid courses offered by major Danish suppliers...
January 10, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29310413/usefulness-of-combined-percutaneous-endoscopic-rendezvous-techniques-after-failed-therapeutic-endoscopic-retrograde-cholangiography-in-the-era-of-endoscopic-ultrasound-guided-rendezvous
#2
Min Jae Yang, Jin Hong Kim, Jae Chul Hwang, Byung Moo Yoo, Soon Sun Kim, Sun Gyo Lim, Je Hwan Won
The rendezvous approach is a salvage technique after failure of endoscopic retrograde cholangiography (ERC). In certain circumstances, percutaneous-endoscopic rendezvous (PE-RV) is preferred, and endoscopic ultrasound-guided rendezvous (EUS-RV) is difficult to perform. We aimed to evaluate PE-RV outcomes, describe the PE-RV techniques, and identify potential indications for PE-RV over EUS-RV.Retrospective analysis was conducted of a prospectively designed ERC database between January 2005 and December 2016 at a tertiary referral center including cases where PE-RV was used as a salvage procedure after ERC failure...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29305438/asymmetric-tdp-pathology-in-primary-progressive-aphasia-with-right-hemisphere-language-dominance
#3
Garam Kim, Shahrooz Vahedi, Tamar Gefen, Sandra Weintraub, Eileen H Bigio, Marek-Marsel Mesulam, Changiz Geula
OBJECTIVE: To quantitatively examine the regional densities and hemispheric distribution of the 43-kDa transactive response DNA-binding protein (TDP-43) inclusions, neurons, and activated microglia in a left-handed patient with right hemisphere language dominance and logopenic-variant primary progressive aphasia (PPA). METHODS: Phosphorylated TDP-43 inclusions, neurons, and activated microglia were visualized with immunohistochemical and histologic methods. Markers were quantified bilaterally with unbiased stereology in language- and memory-related cortical regions...
January 5, 2018: Neurology
https://www.readbyqxmd.com/read/29305332/morphological-and-functional-characterization-of-hemocytes-from-two-deep-sea-vesicomyid-clams-phreagena-okutanii-and-abyssogena-phaseoliformis
#4
Akihiro Tame, Genki Ozawa, Tadashi Maruyama, Takao Yoshida
Deep-sea vesicomyid clams harboring intracellular symbiotic sulfur-oxidizing bacteria are often dominant in chemosynthetic animal communities. Although they are known to have erythrocytes, little is known about other hemocytes. To investigate the types and roles of various hemocytes in vesicomyid clams, we performed morphological, histochemical and functional characterization of the hemocytes in two species, Phreagena okutanii, collected from 873 to 978 m depth, and Abyssogena phaseoliformis, from 5199 to 5355 m...
January 2, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29291539/management-dilemma-of-cholecysto-colonic-fistula-case-report
#5
Waleed Gibreel, Lawrence L Greiten, Ahmed Alsayed, Henry J Schiller
INTRODUCTION: Cholecystocolonic fistula is a rare condition and is found in roughly 1 in every 10,000. It represents 6.3% to 26.5% of all cholecystenteric fistulas (Chowbey et al., 2006; Angrisani et al., 2001; Yamashita et al., 1997). Cholecystocolonic fistula is the second most common intestinal fistula after cholecystoduodenal fistula (Costi et al., 2009). Rarity of this condition, atypical presentation, diagnostic and management challenges, makes it a unique surgical entity. CASE PRESENTATION: A 77-year old male presented with progressive abdominal distension and diarrhea...
December 12, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29288735/myelin-changes-at-the-early-stage-of-5xfad-mice
#6
Lihua Gu, Di Wu, Xiang Tang, Xinyang Qi, Xiaoli Li, Feng Bai, Xiaochun Chen, Qingguo Ren, Zhijun Zhang
Previous studies have demonstrated myelin deficits in Alzheimer's disease (AD). However, it is still unclear whether myelin deficits occur at early stage of AD. Our study aimed to investigate myelin deficits in 5XFAD mice dynamically in different cognition-associated brain regions at early stage of AD. Transmission electron microscopy (TEM) was applied to detect myelin changes in late-myelinating regions such as prelimbic area (PrL), retrosplenial granular cortex (Rsg), field CA1 of hippocampus (CA1) and entorhinal cortex (ERC) respectively at different stages (1, 2, 3 and 5 months of age) in 5XFAD mouse model...
December 27, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/29260307/emerging-roles-for-sphingolipids-in-cellular-aging
#7
REVIEW
Pushpendra Singh, Rong Li
Aging is a gradual loss of physiological functions as organisms' progress in age. Although aging in multicellular organisms is complex, some fundamental mechanisms and pathways may be shared from the single cellular yeast to human. Budding yeast Saccharomyces cerevisiae has been established model system for aging studies. A yeast cell divides asymmetrically to produce two cells that differ in size and age. The one that is smaller coming from bud is a newborn cell that with a full replicative potential head irrespective of the replicative age of its mother-the larger cell from which the bud grows out before division...
December 19, 2017: Current Genetics
https://www.readbyqxmd.com/read/29259791/diagnostic-accuracy-of-high-resolution-mri-as-a-method-to-predict-potentially-safe-endoscopic-and-surgical-planes-in-patients-with-early-rectal-cancer
#8
Svetlana Balyasnikova, James Read, Andrew Wotherspoon, S Rasheed, Paris Tekkis, Diana Tait, David Cunningham, G Brown
Introduction: Early rectal cancer (ERC) assessment should include prediction of the potential excision plane to safely remove lesions with clear deep margins and feasibility of organ preservation. Method: MRI accuracy for differentiating ≤T1sm2 (partially preserved submucosa) or ≤T2 (partially preserved muscularis) versus >T2 tumours was compared with the gold standard of pT stage T1sm1/2 versus ≤pT2 versus >pT2. N stage was also compared. The MRI protocol employed a standard surface phased array coil with a high resolution (0...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29250584/endoscopic-full-thickness-resection-for-t1-early-rectal-cancer-a-case-series-and-video-report
#9
Paola Soriani, Gian Eugenio Tontini, Helmut Neumann, Germana de Nucci, Domenico De Toma, Barbara Bruni, Sara Vavassori, Luca Pastorelli, Maurizio Vecchi, Pavlos Lagoussis
Background and study aims:  Endoscopic treatment of malignant colorectal polyps is often challenging, especially for early rectal cancer (ERC) localized close to the dentate line. Conversely, the surgical approach may result in temporary or definitive stoma and in frequent post-surgical complications. The Full-Thickness Resection Device (FTRD ® ) System (Ovesco Endoscopy, Tübingen, Germany) is a novel system that, besides having other indications, appears to be promising for wall-thickness excision of intestinal T1 carcinoma following incomplete endoscopic resection...
November 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29233740/erc-2017-guidelines-update
#10
Gavin D Perkins, Theresa M Olasveengen, Ian Maconochie, Jasmeet Soar, Jonathan Wyllie, Robert Greif Andrew Lockey, Federico Semeraro, Patrick Van de Voorde, Carsten Lott, Koenraad G Monsieurs, Jerry P Nolan
No abstract text is available yet for this article.
December 9, 2017: Resuscitation
https://www.readbyqxmd.com/read/29229295/the-role-of-the-internist-in-the-patient-blood-management-program
#11
Carlos Jericó Alba, José Antonio García Erce
No abstract text is available yet for this article.
December 8, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/29212940/hiv-1-envelope-glycoprotein-trafficking-through-the-endosomal-recycling-compartment-is-required-for-particle-incorporation
#12
Junghwa Kirschman, Mingli Qi, Lingmei Ding, Jason Hammonds, Krista Dienger-Stambaugh, Jaang-Jiun Wang, Lynne A Lapierre, James R Goldenring, Paul Spearman
The HIV-1 envelope glycoprotein (Env) encodes specific trafficking signals within its long cytoplasmic tail (CT) that regulate incorporation into HIV-1 particles. Rab11-Family Interacting Protein 1C (FIP1C) and Rab14 are host trafficking factors required for Env particle incorporation, suggesting that Env undergoes sorting from the endosomal recycling compartment (ERC) to the site of particle assembly on the plasma membrane. We disrupted outward sorting from the ERC by expressing a C-terminal fragment of FIP1C (FIP1C560-649) and examined the consequences on Env trafficking and incorporation into particles...
December 6, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29183138/-experimental-model-for-cardiogenic-shock-with-pericardial-tamponade
#13
Gábor Bari, Szilárd Szűcs, Dániel Érces, Melinda Ugocsai, Noémi Bozsó, Dóra Balog, Mihály Boros, Gabriella Varga
INTRODUCTION: Pericardial tamponade (PT) is a life-threatening condition, with low cardiac output. The hemodynamic consequences of PT can severely affect the circulation of all tissues, including the microcirculation of the kidneys and the intestinal mucosa. Our aim was to develop a hemodynamically stable and controllable large animal model of PT to study the consequences of cardiogenic shock. METHODS: Two groups of anesthetized vietnamese minipigs (n = 6, both groups) were used...
December 2017: Magyar Sebészet
https://www.readbyqxmd.com/read/29181377/mitochondria-as-sources-and-targets-of-methane
#14
REVIEW
András Tamás Mészáros, Ágnes Lilla Szilágyi, László Juhász, Eszter Tuboly, Dániel Érces, Gabriella Varga, Petra Hartmann
This review summarizes the current knowledge on the role of mitochondria in the context of hypoxic cell biology, while providing evidence of how these mechanisms are modulated by methane (CH4). Recent studies have unambiguously confirmed CH4 bioactivity in various in vitro and in vivo experimental models and established the possibility that CH4 can affect many aspects of mitochondrial physiology. To date, no specific binding of CH4 to any enzymes or receptors have been reported, and it is probable that many of its effects are related to physico-chemical properties of the non-polar molecule...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29171994/hippocampal-stratum-radiatum-lacunosum-and-moleculare-sparing-in-mild-cognitive-impairment
#15
Li Su, Lawrence Hayes, Soteris Soteriades, Guy Williams, Susannah A E Brain, Michael J Firbank, Giulia Longoni, Robert J Arnold, James B Rowe, John T O'Brien
BACKGROUND: Alzheimer's disease (AD) is associated with atrophy in entorhinal cortex (ERC), the hippocampus, and its subfields Cornu Ammonis 1 (CA1) and subiculum, which predict conversion from mild cognitive impairment (MCI) to clinical AD. The stratum radiatum, lacunosum, and moleculare (SRLM) are also important gateways involving ERC and CA1, which are affected by early AD pathology. OBJECTIVE: To assess whether the SRLM is affected in MCI and AD. METHODS: In this proof-of-concept study, 27 controls, 13 subjects with AD, and 22 with MCI underwent 3T MRI...
November 20, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29171108/optimization-and-validation-of-automated-hippocampal-subfield-segmentation-across-the-lifespan
#16
Andrew R Bender, Attila Keresztes, Nils C Bodammer, Yee Lee Shing, Markus Werkle-Bergner, Ana M Daugherty, Qijing Yu, Simone Kühn, Ulman Lindenberger, Naftali Raz
Automated segmentation of hippocampal (HC) subfields from magnetic resonance imaging (MRI) is gaining popularity, but automated procedures that afford high speed and reproducibility have yet to be extensively validated against the standard, manual morphometry. We evaluated the concurrent validity of an automated method for hippocampal subfields segmentation (automated segmentation of hippocampal subfields, ASHS; Yushkevich et al., ) using a customized atlas of the HC body, with manual morphometry as a standard...
November 23, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29128386/a-pilot-study-of-endoscopically-inserted-biodegradable-biliary-stents-in-the-treatment-of-benign-biliary-strictures-and-cystic-duct-leaks
#17
Antti Siiki, Irina Rinta-Kiikka, Juhani Sand, Johanna Laukkarinen
BACKGROUND AND AIMS: Self-expanding biodegradable biliary stents (BDBSs) have recently become available for use in endoscopic retrograde cholangiography (ERC). The aim was to evaluate the effectiveness and safety of novel BDBS in iatrogenic cystic duct leaks and benign biliary strictures (BBSs). MATERIALS AND METHODS: Patients providing informed consent were recruited for the prospective study. Braided self-expanding poly-dioxanone BDBSs were inserted in ERC during the period 2012 to 2016...
November 8, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29112097/predictive-factors-for-long-operative-duration-in-patients-undergoing-laparoscopic-cholecystectomy-after-endoscopic-retrograde-cholangiography-for-combined-choledochocystolithiasis
#18
Ryukyung Lee, Heontak Ha, Young Seok Han, Min Kyu Jung, Jae Min Chun
PURPOSE: Choledochocystolithiasis and its associated complications such as cholangitis and pancreatitis are managed by endoscopic retrograde cholangiography (ERC), with endoscopic stone extraction followed by laparoscopic cholecystectomy (LC). However, affected patients present with complex conditions linked to operative difficulties in performing LC. The aim of this study was to elucidate the predictive factors for a prolonged LC procedure following ERC for treating patients with choledochocystolithiasis...
December 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/29093748/a-systematic-review-on-multiparametric-mr-imaging-in-prostate-cancer-detection
#19
REVIEW
Roberta Fusco, Mario Sansone, Vincenza Granata, Sergio Venanzio Setola, Antonella Petrillo
Background: Literature data suggest that multi-parametric Magnetic Resonance Imaging (MRI), including morphologic T2-weigthed images (T2-MRI) and functional approaches such as Dynamic Contrast Enhanced-MRI (DCE-MRI), Diffusion Weighted Imaging (DWI) and Magnetic Resonance Spectroscopic Imaging (MRSI), give an added value in the prostate cancer localization and local staging. Methods: We performed a systematic review of literature about the role and the potentiality of morphological and functional MRI in prostate cancer, also in a multimodal / multiparametric approach, and we reported the diagnostic accuracy results for different imaging modalities and for different MR coil settings: endorectal coil (ERC) and phased array coil (PAC)...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29089269/erc-vs-direct-cholangioscopy-dawn-of-a-new-reference-standard
#20
Vincent Zimmer
No abstract text is available yet for this article.
October 13, 2017: Digestive and Liver Disease
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