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Mohammad Ahmad, Sunil Bahl, Abhishek Kunwar
OBJECTIVE: To assess the seroprevalence against all three poliovirus serotypes in traditional high risk areas in Bihar, lowest routine immunization coverage areas in Madhya Pradesh and migrant population living in Mumbai urban slums. DESIGN: Cross-sectional Survey. SETTING: Subjects selected by house to house visit (community based) and transported to government health facilities for further study procedures. PARTICIPANTS: 1137 randomly selected healthy infants 6-11 months of age residing in the selected high-risk areas...
August 7, 2016: Indian Pediatrics
Shanzheng Lu, Ganggang Shi, Xiaoxi Xu, Grace Wang, Xu Lan, Peng Sun, Xiang Li, Baoren Zhang, Xiangying Gu, Thomas E Ichim, Hao Wang
BACKGROUND: The endometrial regenerative cell (ERC) is a novel type of adult mesenchymal stem cell isolated from menstrual blood. Previous studies demonstrated that ERCs possess unique immunoregulatory properties in vitro and in vivo, as well as the ability to differentiate into functional hepatocyte-like cells. For these reasons, the present study was undertaken to explore the effects of ERCs on carbon tetrachloride (CCl4)-induced acute liver injury (ALI). METHODS: An ALI model in C57BL/6 mice was induced by administration of intraperitoneal injection of CCl4...
October 22, 2016: Journal of Translational Medicine
Gonzalo Zeballos Sarrato, Enrique Salguero García, Josefa Aguayo Maldonado, Celia Gómez Robles, Marta Thió Lluch, Martín Iriondo Sanz
The International Liaison Committee on Resuscitation (ILCOR) recommendations provide a universal guide of measures to support the transition and resuscitation of newborn after their birth. This guide is expected to be adapted by local groups or committees on resuscitation, according to their own circumstances. The objective of this review is to analyse the main changes, to discuss several of the controversies that have appeared since 2010, and contrasting with other national and international organisations, such as European Resuscitation Council (ERC), American Heart Association (AHA), or the Australian-New Zealand Committee on Resuscitation (ANZCOR)...
October 13, 2016: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
Sâmia Georgia Dantas Linhares, João Carlos Das-Neves Pereira, Paulo Manuel Pêgo Fernades, José Ribas Milanez de Campos
PURPOSE: The aim of this study was to compare the functional exercise capacity and the lung function among patients undergoing early rehabilitation with those submitted to the conventional care after pectus excavatum repair using the Nuss procedure. METHOD: Patients were randomly allocated to the early rehabilitation group (ERG) who started rehabilitation after surgery and the group of the conventional care (CG) received routine care of the institution. They were evaluated before surgery (preoperative) and in hospital discharge day (postoperative)...
October 13, 2016: Pediatric Surgery International
Jian Kang, Jixin Zhang, Yongqian Bai
An evaluation of the oil-spill emergency response capability (OS-ERC) currently in place in modern marine management is required to prevent pollution and loss accidents. The objective of this paper is to develop a novel OS-ERC evaluation model, the importance of which stems from the current lack of integrated approaches for interpreting, ranking and assessing OS-ERC performance factors. In the first part of this paper, the factors influencing OS-ERC are analyzed and classified to generate a global evaluation index system...
October 4, 2016: Marine Pollution Bulletin
Fuyi Li, Chen Li, Jerico Revote, Yang Zhang, Geoffrey I Webb, Jian Li, Jiangning Song, Trevor Lithgow
Glycosylation plays an important role in cell-cell adhesion, ligand-binding and subcellular recognition. Current approaches for predicting protein glycosylation are primarily based on sequence-derived features, while little work has been done to systematically assess the importance of structural features to glycosylation prediction. Here, we propose a novel bioinformatics method called GlycoMine(struct)( for improved prediction of human N- and O-linked glycosylation sites by combining sequence and structural features in an integrated computational framework with a two-step feature-selection strategy...
October 6, 2016: Scientific Reports
L Bos, L Schouten, L van Vught, M Wiewel, D Ong, O Cremer, A Artigas, I Martin-Loeches, A Hoogendijk, T van der Poll, J Horn, N Juffermans, M Schultz, N de Prost, T Pham, G Carteaux, A Mekontso Dessap, C Brun-Buisson, E Fan, G Bellani, J Laffey, A Mercat, L Brochard, B Maitre, P A Howells, D R Thickett, C Knox, D P Park, F Gao, O Tucker, T Whitehouse, D F McAuley, G D Perkins, T Pham, J Laffey, G Bellani, E Fan, L Pisani, J P Roozeman, F D Simonis, A Giangregorio, L R Schouten, S M Van der Hoeven, J Horn, A Serpa Neto, E Festic, A M Dondorp, S Grasso, L D Bos, M J Schultz, M Koster-Brouwer, D Verboom, B Scicluna, K van de Groep, J Frencken, M Schultz, T van der Poll, M Bonten, O Cremer, J I Ko, K S Kim, G J Suh, W Y Kwon, K Kim, J H Shin, O T Ranzani, E Prina, R Menendez, A Ceccato, R Mendez, C Cilloniz, A Gabarrus, M Ferrer, A Torres, A Urbano, L A Zhang, D Swigon, F Pike, R S Parker, G Clermont, C Scheer, S O Kuhn, A Modler, M Vollmer, C Fuchs, K Hahnenkamp, S Rehberg, M Gründling, A Taggu, N Darang, N Öveges, I László, K Tánczos, M Németh, G Lebák, B Tudor, D Érces, J Kaszaki, W Huber, D Trásy, Z Molnár, G Ferrara, V S Kanoore Edul, H S Canales, E Martins, C Canullán, G Murias, M O Pozo, J F Caminos Eguillor, M G Buscetti, C Ince, A Dubin, H D Aya, A Rhodes, N Fletcher, R M Grounds, M Cecconi, M Jacquet-Lagrèze, M Riche, R Schweizer, P Portran, W Fornier, M Lilot, J Neidecker, J L Fellahi, A Escoresca-Ortega, A Gutiérrez-Pizarraya, L Charris-Castro, Y Corcia-Palomo, E Fernandez-Delgado, J Garnacho-Montero, C Roger, L Muller, L Elotmani, J Lipman, J Y Lefrant, J A Roberts, R Muñoz-Bermúdez, M Samper, C Climent, F Vasco, V Sara, S Luque, N Campillo, S Grau Cerrato, J R Masclans, F Alvarez-Lerma, S Carvalho Brugger, G Jimenez Jimenez, M Miralbés Torner, J Trujillano Cabello, B Balsera Garrido, X Nuvials Casals, F Barcenilla Gaite, M Vallverdú Vidal, M Palomar Martínez, V Gusarov, D Shilkin, M Dementienko, E Nesterova, N Lashenkova, A Kuzovlev, M Zamyatin, A Demoule, S Carreira, S Lavault, O Palancca, E Morawiec, J Mayaux, I Arnulf, T Similowski, B S Rasmussen, R G Maltesen, M Hanifa, S Pedersen, S R Kristensen, R Wimmer, M Panigada, G Li Bassi, O T Ranzani, T Kolobow, A Zanella, M Cressoni, L Berra, V Parrini, H Kandil, G Salati, S Livigni, A Amatu, A Andreotti, F Tagliaferri, G Moise, G Mercurio, A Costa, A Vezzani, S Lindau, J Babel, M Cavana, D Consonni, A Pesenti, L Gattinoni, A Torres, P Mansouri, F Zand, L Zahed, F Dehghanrad, M Bahrani, M Ghorbani, B Cambiaghi, O Moerer, T Mauri, N Kunze-Szikszay, C Ritter, A Pesenti, M Quintel, L M Vilander, M A Kaunisto, S T Vaara, V Pettilä, J L G Haitsma Mulier, S Rozemeijer, A M E Spoelstra-de Man, P E Elbers, P R Tuinman, M C de Waard, H M Oudemans-van Straaten, A M A Liberatore, R B Souza, A M C R P F Martins, J C F Vieira, I H J Koh, M Galindo Martínez, R Jiménez Sánchez, L Martínez Gascón, M D Rodríguez Mulero, A Ortín Freire, A Ojados Muñoz, S Rebollo Acebes, Á Fernández Martínez, S Moreno Aliaga, L Herrera Para, J Murcia Payá, F Rodríguez Mulero, P Guerci, Y Ince, P Heeman, B Ergin, C Ince, Z Uz, M Massey, Y Ince, R Papatella, E Bulent, P Guerci, F Toraman, C Ince, E R Longbottom, H D Torrance, H C Owen, C J Hinds, R M Pearse, M J O'Dywer, Z Trogrlic, M van der Jagt, H Lingsma, H H Ponssen, J F Schoonderbeek, F Schreiner, S J Verbrugge, S Duran, T van Achterberg, J Bakker, D A M P J Gommers, E Ista, A Krajčová, P Waldauf, F Duška, A Shah, N Roy, S McKechnie, C Doree, S Fisher, S J Stanworth, J F Jensen, D Overgaard, M H Bestle, D F Christensen, I Egerod, A Pivkina, V Gusarov, I Zhivotneva, N Pasko, M Zamyatin, J F Jensen, I Egerod, M H Bestle, D F Christensen, A Alklit, R L Hansen, H Knudsen, L B Grode, D Overgaard, M Hravnak, L Chen, A Dubrawski, G Clermont, M R Pinsky, S M Parry, L D Knight, B C Connolly, C E Baldwin, Z A Puthucheary, L Denehy, N Hart, P E Morris, J Mortimore, C L Granger, H I Jensen, R Piers, B Van den Bulcke, J Malmgren, V Metaxa, A K Reyners, M Darmon, K Rusinova, D Talmor, A P Meert, L Cancelliere, L Zubek, P Maia, A Michalsen, J Decruyenaere, E Kompanje, S Vanheule, E Azoulay, S Vansteelandt, D Benoit, B Van den Bulcke, R Piers, H I Jensen, J Malmgren, V Metaxa, A K Reyners, M Darmon, K Rusinova, D Talmor, A P Meert, L Cancelliere, L Zubek, P Maia, A Michalsen, J Decruyenaere, E Kompanje, S Vanheule, E Azoulay, S Vansteelandt, D Benoit, C Ryan, D Dawson, J Ball, K Noone, B Aisling, S Prudden, A Ntantana, D Matamis, S Savvidou, M Giannakou, M Gouva, G Nakos, V Koulouras, J Aron, G Lumley, D Milliken, K Dhadwal, B A McGrath, S J Lynch, B Bovento, G Sharpe, E Grainger, S Pieri-Davies, S Wallace, B McGrath, S J Lynch, B Bovento, E Grainger, S Pieri-Davies, G Sharpe, S Wallace, M Jung, J Cho, H Park, G Suh, O Kousha, J Paddle, L Gamrin Gripenberg, M Sundström Rehal, J Wernerman, O Rooyackers, H J de Grooth, W P Choo, A M Spoelstra-de Man, E L Swart, H M Oudemans-van Straaten, L Talan, G Güven, N D Altıntas, M Padar, G Uusvel, L Starkopf, J Starkopf, A Reintam Blaser, M S Kalaiselvan, A S Arunkumar, M K Renuka, R L Shivkumar, M Volbeda, D Ten Kate, M Hoekstra, J M van der Maaten, M W Nijsten, A Komaromi, O Rooyackers, J Wernerman, Å Norberg, M Smedberg, M Mori, L Pettersson, Å Norberg, O Rooyackers, J Wernerman, M Theodorakopoulou, T Christodoulopoulou, A Diamantakis, F Frantzeskaki, M Kontogiorgi, E Chrysanthopoulou, M Lygnos, C Diakaki, A Armaganidis, K Gundogan, E Dogan, R Coskun, S Muhtaroglu, M Sungur, T Ziegler, M Guven, A Kleyman, W Khaliq, D Andreas, M Singer, R Meierhans, R Schuepbach, I De Brito-Ashurst, F Zand, G Sabetian, R Nikandish, F Hagar, M Masjedi, B Maghsudi, A Vazin, M Ghorbani, E Asadpour, K C Kao, L C Chiu, C Y Hung, C H Chang, S H Li, H C Hu, S El Maraghi, M Ali, D Rageb, M Helmy, J Marin-Corral, C Vilà, J R Masclans, A Vàzquez, I Martín-Loeches, E Díaz, J C Yébenes, A Rodriguez, F Álvarez-Lerma, N Varga, A Cortina-Gutiérrez, L Dono, M Martínez-Martínez, C Maldonado, E Papiol, M Pérez-Carrasco, R Ferrer, K Nweze, B Morton, I Welters, M Houard, B Voisin, G Ledoux, S Six, E Jaillette, S Nseir, S Romdhani, R Bouneb, D Loghmari, N Ben Aicha, J Ayachi, K Meddeb, I Chouchène, A Khedher, M Boussarsar, K S Chan, W L Yu, J Marin-Corral, C Vilà, J R Masclans, J Nolla, L Vidaur, J Bonastre, B Suberbiola, J E Guerrero, A Rodriguez, N Ramon Coll, G Jiménez Jiménez, S Carvalho Brugger, J Codina Calero, B Balsera Garrido, M García, M Palomar Martínez, M Vallverdú Vidal, M C de la Torre, E Vendrell, E Palomera, E Güell, J C Yébenes, M Serra-Prat, J F Bermejo-Martín, J Almirall, E Tomas, A Escoval, F Froe, M H Vitoria Pereira, N Velez, E Viegas, E Filipe, C Groves, M Reay, L C Chiu, H C Hu, C Y Hung, C H Chang, S H Li, K C Kao, A Ballin, F Facchin, G Sartori, F Zarantonello, E Campello, C M Radu, S Rossi, C Ori, P Simioni, N Umei, I Shingo, A C Santos, C Candeias, I Moniz, R Marçal, Z Costa E Silva, J M Ribeiro, J F Georger, J P Ponthus, M Tchir, V Amilien, M Ayoub, E Barsam, G Martucci, G Panarello, F Tuzzolino, G Capitanio, V Ferrazza, T Carollo, L Giovanni, A Arcadipane, M López Sánchez, M A González-Gay, F J Llorca Díaz, M I Rubio López, E Zogheib, L Villeret, J Nader, M Bernasinski, P Besserve, T Caus, H Dupont, P Morimont, S Habran, R Hubert, T Desaive, F Blaffart, N Janssen, J Guiot, A Pironet, P Dauby, B Lambermont, F Zarantonello, A Ballin, F Facchin, G Sartori, E Campello, T Pettenuzzo, G Citton, S Rossi, P Simioni, C Ori, C Kirakli, O Ediboglu, S Ataman, M Yarici, F Tuksavul, S Keating, A Gibson, M Gilles, M Dunn, G Price, N Young, P Remeta, P Bishop, M D Fernández Zamora, J Muñoz-Bono, E Curiel-Balsera, E Aguilar-Alonso, R Hinojosa, A Gordillo-Brenes, J A Arboleda-Sánchez, I Skorniakov, D Vikulova, C Whiteley, O Shaikh, A Jones, M Ostermann, L Forni, M Scott, J Sahatjian, W Linde-Zwirble, D Hansell, P Laoveeravat, N Srisawat, M Kongwibulwut, S Peerapornrattana, N Suwachittanont, T O Wirotwan, P Chatkaew, P Saeyub, K Latthaprecha, K Tiranathanagul, S Eiam-Ong, J A Kellum, R E Berthelsen, A Perner, A E K Jensen, J U Jensen, M H Bestle, D J Gebhard, J Price, C E Kennedy, A Akcan-Arikan, A M A Liberatore, R B Souza, A M C R P F Martins, J C F Vieira, Y R Kang, M N Nakamae, I H J Koh, K Hamed, M M Khaled, R Aly Soliman, M Sherif Mokhtar, G Seller-Pérez, D Arias-Verdú, E Llopar-Valdor, I De-Diós-Chacón, G Quesada-García, M E Herrera-Gutierrez, R Hafes, G Carroll, P Doherty, C Wright, I G Guerra Vera, M Ralston, M L Gemmell, A MacKay, E Black, C Wright, R I Docking, R Appleton, M R Ralston, L Gemmell, R Appleton, C Wright, R I Docking, E Black, A Mackay, S Rozemeijer, J L G Haitsma Mulier, J G Röttgering, P W G Elbers, A M E Spoelstra-de Man, P R Tuinman, M C de Waard, H M Oudemans-van Straaten, N Mejeni, J Nsiala, A Kilembe, P Akilimali, G Thomas, I Egerod, A E Andersson, A M Fagerdahl, V Knudsen, K Meddeb, A Ben Cheikh, Y Hamdaoui, J Ayachi, A Guiga, N Fraj, S Romdhani, N Sma, R Bouneb, I Chouchene, A Khedher, N Bouafia, M Boussarsar, A Amirian, B Ziaian, M Masjedi, C Fleischmann, D O Thomas-Rueddel, A Schettler, D Schwarzkopf, A Stacke, K Reinhart, E Filipe, A Escoval, A Martins, P Sousa, N Velez, E Viegas, E Tomas, G Snell, R Matsa, T T S Paary, M S Kalaiselvan, A M Cavalheiro, L L Rocha, C S Vallone, A Tonilo, M D S Lobato, D T Malheiro, G Sussumo, N M Lucino, F Zand, V D Rosenthal, M Masjedi, G Sabetian, B Maghsudi, M Ghorbani, A Sanaei Dashti, A Yousefipour, J R Goodall, M Williamson, E Tant, N Thomas, C Balci, C Gonen, E Haftacı, H Gurarda, E Karaca, B Paldusová, I Zýková, D Šímová, S Houston, L D'Antona, J Lloyd, V Garnelo-Rey, M Sosic, V Sotosek-Tokmazic, J Kuharic, I Antoncic, S Dunatov, A Sustic, C T Chong, M Sim, T Lyovarin, F M Acosta Díaz, S Narbona Galdó, M Muñoz Garach, O Moreno Romero, A M Pérez Bailón, A Carranza Pinel, M Colmenero, A Gritsan, A Gazenkampf, E Korchagin, N Dovbish, R M Lee, M P P Lim, C T Chong, B C L Lim, J J See, R Assis, F Filipe, N Lopes, L Pessoa, T Pereira, N Catorze, M S Aydogan, C Aldasoro, P Marchio, A Jorda, M D Mauricio, S Guerra-Ojeda, M Gimeno-Raga, M Colque-Cano, A Bertomeu-Artecero, M Aldasoro, S L Valles, D Tonon, T Triglia, J C Martin, M C Alessi, N Bruder, P Garrigue, L Velly, S Spina, V Scaravilli, C Marzorati, E Colombo, D Savo, A Vargiolu, G Cavenaghi, G Citerio, A H V Andrade, P Bulgarelli, J A P Araujo, V Gonzalez, V A Souza, A Costa, C Massant, C A C Abreu Filho, R A Morbeck, L E Burgo, R van Groenendael, L T van Eijk, G P Leijte, B Koeneman, M Kox, P Pickkers, A García-de la Torre, M de la Torre-Prados, A Fernández-Porcel, C Rueda-Molina, P Nuevo-Ortega, T Tsvetanova-Spasova, E Cámara-Sola, A García-Alcántara, L Salido-Díaz, X Liao, T Feng, J Zhang, X Cao, Q Wu, Z Xie, H Li, Y Kang, M S Winkler, A Nierhaus, E Mudersbach, A Bauer, L Robbe, C Zahrte, E Schwedhelm, S Kluge, C Zöllner, B Morton, E Mitsi, S H Pennington, J Reine, A D Wright, R Parker, I D Welters, J D Blakey, G Rajam, E W Ades, D M Ferreira, D Wang, A Kadioglu, S B Gordon, R Koch, M Kox, J Rahamat-Langedoen, J Schloesser, M de Jonge, P Pickkers, J Bringue, R Guillamat-Prats, E Torrents, M L Martinez, M Camprubí-Rimblas, A Artigas, L Blanch, S Y Park, Y B Park, D K Song, S Shrestha, S H Park, Y Koh, M J Park, C W Hong, O Lesur, D Coquerel, X Sainsily, J Cote, T Söllradl, A Murza, L Dumont, R Dumaine, M Grandbois, P Sarret, E Marsault, D Salvail, M Auger-Messier, F Chagnon, M P Lauretta, E Greco, A Dyson, M Singer, S Preau, M Ambler, A Sigurta, S Saeed, M Singer, L Topcu Sarıca, N Zibandeh, D Genc, F Gul, T Akkoc, E Kombak, L Cinel, T Akkoc, I Cinel, S J Pollen, N Arulkumaran, M Singer, H D Torrance, E R Longbottom, G Warnes, C J Hinds, D J Pennington, K Brohi, M J O'Dwyer, H Y Kim, S Na, J Kim, Y F Chang, A Chao, P Y Shih, C T Lee, Y C Yeh, L W Chen, M Adriaanse, Z Trogrlic, E Ista, H Lingsma, W Rietdijk, H H Ponssen, J F Schoonderbeek, F Schreiner, S J Verbrugge, S Duran, D A M P J Gommers, M van der Jagt, S Funcke, S Sauerlaender, B Saugel, H Pinnschmidt, D A Reuter, R Nitzschke, S Perbet, C Biboulet, A Lenoire, D Bourdeaux, B Pereira, B Plaud, J E Bazin, V Sautou, A Mebazaa, J M Constantin, M Legrand, Y Boyko, P Jennum, M Nikolic, H Oerding, R Holst, P Toft, H K Nedergaard, T Haberlandt, H I Jensen, P Toft, S Park, S Kim, Y J Cho, Y J Lim, A Chan, S Tang, S L Nunes, S Forsberg, H Blomqvist, L Berggren, M Sörberg, T Sarapohja, C J Wickerts, J G M Hofhuis, L Rose, B Blackwood, E Akerman, J Mcgaughey, I Egerod, M Fossum, H Foss, E Georgiou, H J Graff, M Kalafati, R Sperlinga, A Schafer, A G Wojnicka, P E Spronk, F Zand, F Khalili, R Afshari, G Sabetian, M Masjedi, B Maghsudi, H Haddad Khodaei, S Javadpour, P Petramfar, S Nasimi, A Vazin, B Ziaian, H Tabei, A Gunther, J O Hansen, P Sackey, H Storm, J Bernhardsson, Ø Sundin, A Bjärtå, A Bienert, P Smuszkiewicz, P Wiczling, K Przybylowski, A Borsuk, I Trojanowska, J Matysiak, Z Kokot, M Paterska, E Grzeskowiak, A Messina, E Bonicolini, D Colombo, G Moro, S Romagnoli, A R De Gaudio, F Della Corte, S M Romano, J A Silversides, E Major, E E Mann, A J Ferguson, D F Mcauley, J C Marshall, B Blackwood, E Fan, J A Diaz-Rodriguez, R Silva-Medina, E Gomez-Sandoval, N Gomez-Gonzalez, R Soriano-Orozco, P L Gonzalez-Carrillo, M Hernández-Flores, K Pilarczyk, J Lubarksi, D Wendt, F Dusse, J Günter, B Huschens, E Demircioglu, H Jakob, A Palmaccio, A M Dell'Anna, D L Grieco, F Torrini, C Iaquaniello, F Bongiovanni, M Antonelli, L Toscani, D Antonakaki, D Bastoni, H D Aya, A Rhodes, M Cecconi, M Jozwiak, F Depret, J L Teboul, J Alphonsine, C Lai, C Richard, X Monnet, I László, G Demeter, N Öveges, K Tánczos, M Németh, D Trásy, I Kertmegi, D Érces, B Tudor, J Kaszaki, Z Molnár, A Hasanin, A Lotfy, A El-Adawy, H Nassar, S Mahmoud, A Abougabal, A Mukhtar, F Quinty, S Habchi, A Luzi, E Antok, G Hernandez, B Lara, L Enberg, M Ortega, P Leon, C Kripper, P Aguilera, E Kattan, J Bakker, W Huber, M Lehmann, S Sakka, B Bein, R M Schmid, J Preti, J Creteur, A Herpain, J Marc, E Zogheib, F Trojette, S Bar, L Kontar, D Titeca, J Richecoeur, B Gelee, N Verrier, R Mercier, E Lorne, J Maizel, H Dupont, M Slama, M E Abdelfattah, A Eladawy, M A Ali Elsayed, A Mukhtar, A Pedraza Montenegro, E Monares Zepeda, J Franco Granillo, J S Aguirre Sánchez, G Camarena Alejo, A Rugerio Cabrera, A A Tanaka Montoya, C Lee, F Hatib, M Cannesson, P Theerawit, T Morasert, Y Sutherasan, G Zani, S Mescolini, M Diamanti, R Righetti, A Scaramuzza, M Papetti, M Terenzoni, C Gecele, M Fusari, K A Hakim, A Chaari, M Ismail, A H Elsaka, T M Mahmoud, K Bousselmi, V Kauts, W F Casey, S D Hutchings, D Naumann, J Wendon, S Watts, E Kirkman, Z Jian, S Buddi, C Lee, J Settels, F Hatib, M R Pinsky, P Bertini, F Guarracino, C Trepte, P Richter, S A Haas, V Eichhorn, J C Kubitz, D A Reuter, M S Soliman, W I Hamimy, A Z Fouad, A M Mukhtar, M Charlton, L Tonks, L Mclelland, T J Coats, J P Thompson, M R Sims, D Williams, D Z Roushdy, R A Soliman, R A Nahas, M Y Arafa, W T Hung, C C Chiang, W C Huang, K C Lin, S C Lin, C C Cheng, P L Kang, S R Wann, G Y Mar, C P Liu, M Lopez Carranza, H Sancho Fernandez, J A Sanchez Roman, F Lucena, A Campanario Garcia, A Loza Vazquez, A Lesmes Serrano, L Sayagues Moreira, R Vidal-Perez, U Anido Herranz, J M Garcia Acuna, C Pena Gil, J L Garcia Allut, P Rascado Sedes, C Martin Lopez, E Saborido Paz, C Galban Rodriguez, J R Gonzalez-Juanatey, A Vallejo-Baez, M V de la Torre-Prados, P Nuevo-Ortega, A Fernández-Porcel, E Cámara-Sola, T Tsvetanova-Spasova, C Rueda-Molina, L Salido-Díaz, A García-Alcántara, J Aron, R Marharaj, K Gervasio, M Bottiroli, M Mondino, D De Caria, A Calini, E Montrasio, F Milazzo, M P Gagliardone, A Vallejo-Báez, M V de la Torre-Prados, P Nuevo-Ortega, A Fernández-Porcel, E Cámara-Sola, T Tsvetanova-Spasova, C Rueda-Molina, L Salido-Díaz, A García-Alcántara, L Sayagues Moreira, R Vidal-Perez, U Anido, C Pena Gil, J M Garcia Acuna, P Rascado Sedes, C Martin Lopez, E Saborido Paz, J L Garcia Allut, C Galban Rodriguez, J R Gonzalez-Juanatey, Y 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O'Flynn, P Stapleton, M Lynch, B Marsh, E Carton, C O'Loughlin, K C Cheng, M I Sung, M O Elghonemi, M H Saleh, T S Meyhoff, M Krag, P B Hjortrup, A Perner, M H Møller, T Öhman, T Sigmundsson, E Redondo, M Hallbäck, F Suarez-Sipmann, H Björne, C Hällsjö Sander, M Cressoni, D Chiumello, C Chiurazzi, M Brioni, I Algieri, M Guanziroli, G Vergani, T Tonetti, I Tomic, A Colombo, F Crimella, E Carlesso, A Colombo, V Gasparovic, L Gattinoni, R El-Sherif, M Abd Al-Basser, A Raafat, A El-Sherif, F D Simonis, L R A Schouten, O L Cremer, D S Y Ong, G Amoruso, G Cinnella, M J Schultz, L D J Bos, W Huber, P Schmidle, M Findeisen, P Hoppmann, J Jaitner, F Brettner, R M Schmid, T Lahmer, E Festic, G Rajagopalan, V Bansal, R Frank, R Hinds, J Levitt, S Siddiqui, J P Gilbert, K Sim, C H Wang, H C Hu, I J Li, W R Tang, K C Kao, P Persona, A De Cassai, M Franco, F Facchin, C Ori, S Rossi, A Goffi, S H Li, H C Hu, L C Chiu, C Y Hung, C H Chang, K C Kao, B Llorente Ruiz, J Lujan Varas, R Molina Montero, C Pintado Delgado, O Navarrete, M Vazquez Mezquita, E Alonso Peces, M A M Nakamura, L A Hajjar, F R B G Galas, T A Ortiz, M B P Amato, L Bitker, N Costes, D Le Bars, F Lavenne, D Mojgan, J C Richard, C Chiurazzi, M Cressoni, D Massari, M Guanziroli, G Vergani, M Gotti, M Brioni, I Algieri, P Cadringher, T Tonetti, D Chiumello, L Gattinoni, A Zerman, M Türkoğlu, G Arık, F Yıldırım, Z Güllü, I Kara, N Boyacı, B Basarık Aydoğan, Ü Gaygısız, K Gönderen, G Aygencel, M Aydoğdu, Z Ülger, G Gürsel, J Riera, C Maldonado Toral, C Mazo, M Martínez, J Baldirà, L Lagunes, A Roman, M Deu, J Rello, D J Levine, R M Mohus, Å Askim, J Paulsen, A Mehl, A T Dewan, J K Damås, E Solligård, B O Åsvold, J Paulsen, Å Askim, R M Mohus, A Mehl, A DeWan, E Solligård, J K Damås, B O Åsvold, O Aktepe, A Kara, H Yeter, A Topeli, M Norrenberg, M Devroey, H Khader, J C Preiser, Z Tang, C Qiu, L Tong, C Cai, M Theodorakopoulou, A Diamantakis, M Kontogiorgi, E Chrysanthopoulou, T Christodoulopoulou, F Frantzeskaki, M Lygnos, O Apostolopoulou, A Armaganidis, J Y Moon, M R Park, I S Kwon, G R Chon, J Y Ahn, S J Kwon, Y J Chang, J Y Lee, S Y Yoon, J W Lee, M Kostalas, J Mckinlay, G Kooner, G Dudas, A Horton, C Kerr, N Karanjia, B Creagh-Brown, N D Altintas, S Izdes, O Keremoglu, A Alkan, S Neselioglu, O Erel, N Tardif, T Gustafsson, O Rooyackers, K N MacEachern, M Traille, I Bromberg, S E Lapinsky, M J Moore, Z Tang, C Cai, L Tong, J L García-Garmendia, F Villarrasa-Clemente, F Maroto-Monserrat, O Rufo-Tejeiro, V Jorge-Amigo, M Sánchez-Santamaría, C Colón-Pallarés, A Barrero-Almodóvar, S Gallego-Lara, C T Anthon, R B Müller, N Haase, K Møller, P B Hjortrup, J Wetterslev, A Perner, M Nakanishi, A Kuriyama, T Fukuoka, M A Abd El Halim, M H Elsaid Hafez, A M Moktar, A Eladawy, H M Elazizy, K Abdel Hakim, A Chaari, M Elbahr, M Ismail, T Mahmoud, V Kauts, K Bousselmi, E Khalil, W Casey, S H Zaky, A Rizk, M O Elghonemi, R Ahmed, J C F Vieira, R B Souza, A M A Liberatore, I H J Koh, G A Ospina-Tascón, A F Garcia Marin, G J Echeverry, W F Bermudez, H J Madriñan-Navia, J D Valencia, E Quiñonez, A Marulanda, C A Arango-Dávila, A Bruhn, G Hernandez, D De Backer, D Orbegozo Cortes, F Su, J L Vincent, J Creteur, L Tullo, L Mirabella, P Di Molfetta, G Cinnella, M Dambrosio, C Villavicencio Lujan, J Leache Irigoyen, M Cartanya Ferré, R Carbonell García, A Mukhtar, M Ahmed, M El Ayashi, A Hasanin, E Ayman, M Salem, A Eladawy, S Fathy, H Nassar, A Zaghlol, M F Aguilar Arzapalo, Å Valsø, K Sunde, T Rustøen, I Schou-Bredal, L Skogstad, K Tøien, C Padilla, Y Palmeiro, W Egbaria, R Kigli, B Maertens, K Blot, S Blot, E Santana-Santos, E R Dos Santos, R E D L Ferretti-Rebustini, R D C C D O Dos Santos, R G S Verardino, L A Bortolotto, A M Doyle, I Naldrett, J Tillman, S Price, S Shrestha, P Pearson, J Greaves, D Goodall, A Berry, A Richardson, G O Odundo, P Omengo, P Obonyo, N M Chanzu, R Kleinpell, S J Sarris, P Nedved, M Heitschmidt, H Ben-Ghezala, S Snouda, S Djobbi, H Ben-Ghezala, S Snouda, L Rose, N K J Adhikari, D Leasa, D Fergusson, D A Mckim, J Weblin, O Tucker, D McWilliams, F Doesburg, F Cnossen, W Dieperink, W Bult, M W N Nijsten, G A Galvez-Blanco, E Monares Zepeda, C I Olvera Guzman, J S Aguirre Sánchez, J Franco Granillo, J Santos Stroud, R Thomson, M Llaurado-Serra, A Lobo-Civico, M Pi-Guerrero, I Blanco-Sanchez, A Piñol-Tena, C Paños-Espinosa, Y Alabart-Segura, B Coloma-Gomez, A Fernandez-Blanco, F Braga-Dias, M Treso-Geira, A Valeiras-Valero, L Martinez-Reyes, A Sandiumenge, M F Jimenez-Herrera, R Prada, P Juárez, R Argandoña, J J Díaz, C Sánchez Ramirez, P Saavedra, S Ruiz Santana, O Obukhova, S Kashiya, I A Kurmukov, A M Pronina, P Simeone, L Puybasset, G Auzias, O Coulon, B Lesimple, G Torkomian, L Velly, A Bienert, A Bartkowska-Sniatkowska, P Wiczling, O Szerkus, D Siluk, J Bartkowiak-Wieczorek, J Rosada-Kurasinska, J Warzybok, A Borsuk, R Kaliszan, E Grzeskowiak, C Hernandez Caballero, S Roberts, G Isgro, D Hall, G Guillaume, O Passouant, F Dumas, W Bougouin, B Champigneulle, M Arnaout, J Chelly, J D Chiche, O Varenne, J P Mira, E Marijon, A Cariou, M Beerepoot, H R Touw, K Parlevliet, C Boer, P W Elbers, P R Tuinman, Á J Roldán Reina, Y Corcia Palomo, R Martín Bermúdez, L Martín Villén, I Palacios García, J R Naranjo Izurieta, J B Pérez Bernal, F J Jiménez Jiménez, F Cota-Delgado, M V de la Torre-Prados, A Fernández-Porcel, P Nuevo-Ortega, E Cámara-Sola, T Tsvetanova-Spasova, C Rueda-Molina, L Salido-Díaz, A García-Alcántara, T Kaneko, H Tanaka, M Kamikawa, R Karashima, S Iwashita, H Irie, S Kasaoka, O Arola, R Laitio, A Saraste, J Airaksinen, M Pietilä, M Hynninen, J Wennervirta, M Bäcklund, E Ylikoski, P Silvasti, E Nukarinen, J Grönlund, V P Harjola, J Niiranen, K Korpi, M Varpula, R O Roine, T Laitio, S Salah, B G Hassen, A Mohamed Fehmi, S Kim, Y C Hsu, J Barea-Mendoza, C García-Fuentes, M Castillo-Jaramillo, H Dominguez-Aguado, R Viejo-Moreno, L Terceros-Almanza, S Bermejo Aznárez, C Mudarra-Reche, W Xu, M Chico-Fernández, J C Montejo-González, K Crewdson, M Thomas, M Merghani, L Fenner, P Morgan, D Lockey, E J van Lieshout, B Oomen, J M Binnekade, D A Dongelmans, R J de Haan, N P Juffermans, M B Vroom, R Algarte, L Martínez, B Sánchez, I Romero, F Martínez, S Quintana, J Trenado, O Sheikh, D Pogson, R Clinton, F Riccio, L Gemmell, A MacKay, A Arthur, L Young, A Sinclair, D Markopoulou, K Venetsanou, L Filippou, E Salla, S Stratouli, I Alamanos, A H Guirgis, R Gutiérrez Rodriguez, M J Furones Lorente, I Macias Guarasa, A Ukere, S Meisner, G Greiwe, B Opitz, D Benten, B Nashan, L Fischer, C J C Trepte, D A Reuter, S A Haas, C R Behem, G Tavazzi, B Ana, A Vazir, D Gibson, S Price, M Masjedi, M R Hadavi, M Riahi Alam, M R Sasani, N Parenti, F Agrusta, C Palazzi, B Pifferi, R Sganzerla, F Tagliazucchi, A Luciani, M Möller, J Müller-Engelmann, G Montag, P Adams, C Lange, J Neuzner, R Gradaus, K H Wodack, F Thürk, A D Waldmann, M F Grässler, S Nishimoto, S H Böhm, E Kaniusas, D A Reuter, C J Trepte, T Sigmundsson, T Öhman, E Redondo, M Hallbäck, M Wallin, F Suarez Sipman, A Oldner, C Hällsjö Sander, H Björne, L Colinas, G Hernandez, R Vicho, M Serna, R Cuena, A Canabal, A Chaari, K Abdel Hakim, M Etman, M El Bahr, A El Sakka, K Bousselmi, A Arali, V Kauts, W F Casey, O Bond, P De Santis, E Iesu, F Franchi, J L Vincent, J Creteur, S Scolletta, F S Taccone, Z Marutyan, L Hamidova, A Shakotko, V Movsisyan, I Uysupova, A Evdokimov, S Petrikov, C Gonen, E Haftacı, C Balci, F J Redondo Calvo, N Bejarano, V Baladron, R Villazala, J Redondo, D Padilla, P Villarejo, A Akcan-Arikan, C E Kennedy, M F Aguilar Arzapalo, C Gomez-Gonzalez, S Mas-Font, A Puppo-Moreno, M Herrera-Gutierrez, M Garcia-Garcia, S Aldunate-Calvo, E P Plata-Menchaca, X L Pérez-Fernández, M Estruch, A Betbese-Roig, P Cárdenas Campos, M Rojas Lora, N D Toapanta Gaibor, R S Contreras Medina, V D Gumucio Sanguino, E J Casanova, J Sabater Riera, K Kritmetapak, S Peerapornratana, P Kittiskulnam, T Dissayabutra, K Tiranathanagul, P Susantithapong, K Praditpornsilpa, K Tungsanga, S Eiam-Ong, N Srisawat, T Winkelmann, T Busch, J Meixensberger, S Bercker, E M Flores Cabeza, M Sánchez Sánchez, N Cáceres Giménez, C Gutierrez Melón, E Herrero de Lucas, P Millán Estañ, M Hernández Bernal, A Garcia de Lorenzo Y Mateos, B Ergin, P Guerci, P A C Specht, Y Ince, C Ince, M Balik, M Zakharchenko, F Los, H Brodska, C de Tymowski, P Augustin, M Desmard, P Montravers, S N Stapel, R de Boer, H M Oudemans, A Hollinger, T Schweingruber, F Jockers, M Dickenmann, M Siegemund, N Runciman, M Ralston, R Appleton, T Mauri, L Alban, C Turrini, T Sasso, T Langer, M Panigada, P Taccone, E Carlesso, C Marenghi, G Grasselli, A Pesenti, P Wibart, T Reginault, M Garcia, B Barbrel, A Benard, C Bader, F Vargas, H N Bui, G Hilbert, J M Serrano Simón, P Carmona Sánchez, F Ruiz Ferrón, M García de Acilu, J Marin, V Antonia, L Ruano, M Monica, R Ferrer, J R Masclans, O Roca, G Hong, D H Kim, Y S Kim, J S Park, Y K Jee, Z Yu Xiang, W Jia-Xing, W Xiao 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S Lundin, K Torén, M Eckerström, A Wallin, A C Waldenström, F C Riccio, D Pogson, A C P Antonio, A F Leivas, F Kenji, E James, P Morgan, G Carroll, L Gemmell, A MacKay, C Wright, J Ballantyne, S Jonnada, C S Gerrard, N Jones, J D Salciccioli, D C Marshall, M Komorowski, A Hartley, M C Sykes, R Goodson, J Shalhoub, J R Fernández Villanueva, R Fernández Garda, A M López Lago, E Rodríguez Ruiz, R Hernández Vaquero, C Galbán Rodríguez, E Varo Pérez, C Hilasque, I Oliva, G Sirgo, M C Martin, M Olona, M C Gilavert, M Bodí, C Ebm, G Aggarwal, S Huddart, N Quiney, M Cecconi, S M Fernandes, J Santos Silva, J Gouveia, D Silva, R Marques, H Bento, A Alvarez, Z Costa Silva, D Díaz Diaz, M Villanova Martínez, E Palencia Herrejon, A Martinez de la Gandara, G Gonzalo, M A Lopez, P Ruíz de Gopegui Miguelena, C I Bernal Matilla, P Sánchez Chueca, M D C Rodríguez Longares, R Ramos Abril, A L Ruíz Aguilar, R Garrido López de Murillas, R Fernández Fernández, P Morales Laborías, M A Díaz Castellanos, M E Morales Laborías, J Cho, J Kim, J Park, S Woo, T West, E Powell, A Rimmer, C Orford, N Jones, J Williams, C I Bernal Matilla, P Ruiz de Gopegui Miguelena, P Sánchez Chueca, R Ramos Abril, M D C Rodríguez Longares, A L Ruíz Aguilar, R Garrido López de Murillas, R S Bourne, R Shulman, M Tomlin, G H Mills, M Borthwick, W Berry, D García Huertas, F Manzano, F Villagrán-Ramírez, A Ruiz-Perea, C Rodríguez-Mejías, F Santiago-Ruiz, M Colmenero-Ruiz, C König, B Matt, A Kortgen, C S Hartog, A Wong, C Balan, G Barker, N Srisawat, S Peerapornratana, P Laoveeravat, S Tachaboon, S Eiam-Ong, J Paratz, G Kayambu, R Boots, M F Aguilar Arzapalo, R Vlasenko, E Gromova, S Loginov, M Kiselevskiy, Y Dolgikova, K B Tang, C M Chau, K N Lam, E Gil, G Y Suh, C M Park, J Park, C R Chung, C T Lee, A Chao, P Y Shih, Y F Chang, C H Lai, Y C Hsu, Y C Yeh, Y J Cheng, V Colella, N Zarrillo, M D'Amico, F Forfori, B Pezza, T Laddomada, V Beltramelli, M L Pizzaballa, A Doronzio, B Balicco, D Kiers, W van der Heijden, J Gerretsen, Q de Mast, S El Messaoudi, G Rongen, M Gomes, M Kox, P Pickkers, N P Riksen, Y Kashiwagi, M Okada, K Hayashi, Y Inagaki, S Fujita, M N Nakamae, Y R Kang, R B Souza, A M A Liberatore, I H J Koh, A Blet, M Sadoune, J Lemarié, N Bihry, R Bern, E Polidano, R Merval, J M Launay, B Lévy, J L Samuel, A Mebazaa, J Hartmann, S Harm, V Weber
No abstract text is available yet for this article.
September 2016: Intensive Care Medicine Experimental
Roel Vermeulen, Lützen Portengen
OBJECTIVES: Recently, diesel motor exhaust (DME) has been classified as a known human carcinogen. We used data from epidemiological studies of diesel exposures to perform a quantitative risk assessment to calculate DME exposure levels, expressed as elemental carbon (EC), corresponding to acceptable risk (AR) and maximum tolerable risk (MTR) levels of 4 to 10(-5) and 4 to 10(-3) for the lifetime excess probability of dying from lung cancer. METHODS: Previously published slope estimates (n=14) of the exposure-response curve (ERC) for EC exposure and lung cancer were used in life-table analyses to calculate EC exposure levels corresponding to the specified AR and MTR levels...
September 28, 2016: Occupational and Environmental Medicine
Rodolfo B Anchieta, Lucas S Machado, Ronaldo Hirata, Paulo G Coelho, Estevam A Bonfante
This study evaluated the probability of survival (reliability) of platform-switched fixed dental prostheses (FDPs) cemented on different implant-abutment connection designs. Eighty-four-three-unit FDPs (molar pontic) were cemented on abutments connected to two implants of external or internal hexagon connection. Four groups (n = 21 each) were established: external hexagon connection and regular platform (ERC); external hexagon connection and switched platform (ESC); internal hexagon and regular platform (IRC); and internal hexagon and switched platform (ISC)...
October 2016: European Journal of Oral Sciences
K Fink, B Schmid, H-J Busch
The revised guidelines for cardiopulmonary resuscitation were implemented by the European Resuscitation Council (ERC) in October 2015. There were few changes concerning basic and advanced life support; however, some issues were clarified compared to the ERC recommendations from 2010. The present paper summarizes the procedures of basic and advanced life support according to the current guidelines and highlights the updates of 2015. Furthermore, the article depicts future prospects of cardiopulmonary resuscitation that may improve outcome of patients after cardiac arrest in the future...
September 27, 2016: Medizinische Klinik, Intensivmedizin und Notfallmedizin
Masaaki Shimatani, Hisashi Hatanaka, Hirofumi Kogure, Koichiro Tsutsumi, Hiroki Kawashima, Keiji Hanada, Tomoki Matsuda, Tomoki Fujita, Makoto Takaoka, Tomonori Yano, Atsuo Yamada, Hironari Kato, Kazuichi Okazaki, Hironori Yamamoto, Hideki Ishikawa, Kentaro Sugano
OBJECTIVES: To evaluate the utility and safety of a short-type double-balloon endoscope (DBE) in the treatment of biliary disease in patients with surgically altered gastrointestinal (GI) anatomy. METHODS: This study was conducted as a multicenter, single-arm, prospective trial at five tertiary academic care centers and three community-based hospitals in Japan. Consecutive patients with biliary disease with altered GI anatomy were prospectively included in this study...
September 27, 2016: American Journal of Gastroenterology
Jason G Bill, Michael Darcy, Larissa L Fujii-Lau, Daniel K Mullady, Srinivas Gaddam, Faris M Murad, Dayna S Early, Steven A Edmundowicz, Vladimir M Kushnir
BACKGROUND AND STUDY AIMS: Selective biliary cannulation is unsuccessful in 5 % to 10 % of patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) for malignant distal biliary obstruction (MDBO). Percutaneous biliary drainage (PBD) has been the gold standard, but endoscopic ultrasound guided rendezvous (EUSr) have been increasingly used for biliary decompression in this patient population. Our aim was to compare the initial success rate, long-term efficacy, and safety of PBD and EUSr in relieving MDBO after failed ERC Patients and methods: A retrospective study involving 50 consecutive patients who had an initial failed ERCP for MDBO...
September 2016: Endoscopy International Open
Kimberly-Anne Tan, Mathew D Sewell, Andrew J Clarke, Daniel Chan, Oliver M Stokes, Shahid N Khan, Michael Hutton
PURPOSE OF THE STUDY: Pacemakers are currently identified as a contraindication for the use of magnetic growth rods (MGRs). This arises from concern that magnetic fields generated by the MGR external remote controller (ERC) during lengthening procedures may induce pacemaker dysfunction. We investigated (1) whether MGR lengthening affects pacemaker function, and (2) if the magnetic field of a pacemaker affects MGR lengthening. METHODS: MGRs were tested in conjunction with an magnetic resonance imaging-compatible pacemaker, which was connected to a virtual patient under continuous cardiac monitoring...
September 15, 2016: Journal of Pediatric Orthopedics
Ferreol Salomon, Simon Keay, Nicolas Carayon, Jean-Philippe Goiran
Over the last 20 years, the geoarchaeology of ancient harbours has been a very active area of research around the Mediterranean basin, generating much palaeoenvironmental data from many sites, including estimations of sedimentation rates, the height of the ancient sea-level at different dates and palaeo-geographical reconstructions. Combining this information has proved a major challenge. This article proposes a new chart called the Palaeoenvironmental Age-Depth Model (PADM chart), that allows the researchers to combine all relevant indicators in order to estimate harbour potential of a given ancient port, and to generate comparable data between harbours in terms of degree of closure and water depth available against a synchronised chronology...
2016: PloS One
Masaaki Shimatani, Makoto Takaoka, Kazuichi Okazaki
We report a successful endoscopic stone extraction using a short type double-balloon endoscope (DBE) (EI-530 B; FUJIFILM Co, Tokyo, Japan) combined with long-type ultra-slim endoscope (L-USE) (EC-530XP; FUJIFILM Co, Tokyo, Japan) without using contrast media for intrahepatic stones in patient allergic to iodine with post-operation. A 43 year-old man with a history of congenital biliary dilatation who had undergone choledocojejunostomy and Roux-en Y reconstruction 37 years previously (Fig. 1-A) and posterior lateral hepatic segmentectomy and caudate lobectomy for intrahepatic stone 10 years previously was admitted for acute cholangitis caused by recurrence of intrahepatic stone and stenosis in choledochojejunal anastomosis (Fig...
September 8, 2016: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
M V Spampinato, B R Langdon, K E Patrick, R O Parker, H Collins, E Pravata'
INTRODUCTION: This study aimed to examine the relationship between gender, apolipoprotein E (APOE) genotype, and mesial temporal atrophy in mild cognitive impairment (MCI) with and without progression to Alzheimer's disease (AD). METHODS: We evaluated 236 MCI patients with (n = 121) and without (n = 115) AD progression. Longitudinal MRI-based hippocampal volumes (HV) and entorhinal cortex (ERC) thickness were obtained. The Clinical Dementia Rating Sum of Boxes (CDR-SB) score was used to assess disease severity...
September 2, 2016: Neuroradiology
Sebastian Moran, Anna Martínez-Cardús, Sergi Sayols, Eva Musulén, Carme Balañá, Anna Estival-Gonzalez, Cátia Moutinho, Holger Heyn, Angel Diaz-Lagares, Manuel Castro de Moura, Giulia M Stella, Paolo M Comoglio, Maria Ruiz-Miró, Xavier Matias-Guiu, Roberto Pazo-Cid, Antonio Antón, Rafael Lopez-Lopez, Gemma Soler, Federico Longo, Isabel Guerra, Sara Fernandez, Yassen Assenov, Christoph Plass, Rafael Morales, Joan Carles, David Bowtell, Linda Mileshkin, Daniela Sia, Richard Tothill, Josep Tabernero, Josep M Llovet, Manel Esteller
BACKGROUND: Cancer of unknown primary ranks in the top ten cancer presentations and has an extremely poor prognosis. Identification of the primary tumour and development of a tailored site-specific therapy could improve the survival of these patients. We examined the feasability of using DNA methylation profiles to determine the occult original cancer in cases of cancer of unknown primary. METHODS: We established a classifier of cancer type based on the microarray DNA methylation signatures (EPICUP) in a training set of 2790 tumour samples of known origin representing 38 tumour types and including 85 metastases...
October 2016: Lancet Oncology
Eske Christiane Gertje, John Pluta, Sandhitsu Das, Lauren Mancuso, Dasha Kliot, Paul Yushkevich, David Wolk
BACKGROUND: Volumetry of medial temporal lobe (MTL) structures to diagnose Alzheimer's disease (AD) in its earliest symptomatic stage could be of great importance for interventions or disease modifying pharmacotherapy. OBJECTIVE: This study aimed to demonstrate the first application of an automatic segmentation method of MTL subregions in a clinical population. Automatic segmentation of magnetic resonance images (MRIs) in a research population has previously been shown to detect evidence of neurodegeneration in MTL subregions and to help discriminate AD and mild cognitive impairment (MCI) from a healthy comparison group...
October 4, 2016: Journal of Alzheimer's Disease: JAD
F D Prieto-Martínez, A Peña-Castillo, O Méndez-Lucio, E Fernández-de Gortari, J L Medina-Franco
In light of the emerging field of Epi-informatics, ie, computational methods applied to epigenetic research, molecular docking, and dynamics, pharmacophore and activity landscape modeling and QSAR play a key role in the development of modulators of DNA methyltransferases (DNMTs), one of the major epigenetic target families. The increased chemical information available for modulators of DNMTs has opened up the avenue to explore the epigenetic relevant chemical space (ERCS). Herein, we discuss recent progress on the identification and development of inhibitors of DNMTs as potential epi-drugs and epi-probes that have been driven by molecular modeling and chemoinformatics methods...
2016: Advances in Protein Chemistry and Structural Biology
Po-Hung Chiang, Kwok-Hung Lai, Tzung-Jiun Tsai, Kung-Hung Lin, Kai-Ming Wang, Sung-Shuo Kao, Wei-Chih Sun, Jin-Shiung Cheng, Ping-I Hsu, Wei-Lun Tsai, Wen-Chi Chen, Yun-Da Li, E-Ming Wang, Huey-Shyan Lin, Hoi-Hung Chan
BACKGROUND: Sometimes, no definite filling defect could be found by cholangiogram (ERC) during the endoscopic retrograde cholangio-pancreatiographic (ERCP) exam; even prior images had evidence of common bile duct stones (CBDS). We aimed in estimating the positive rate of extraction of CBDS who had treated by endoscopic sphincterotomy/endoscopic papillary balloon dilation (EST/EPBD) with negative ERC finding. METHODS: One hundred forty-one patients with clinically suspicious of CBDS but negative ERC, who had received EST/EPBD treatments was enrolled...
2016: BMC Gastroenterology
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