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https://www.readbyqxmd.com/read/28806619/a-long-term-recurrence-free-survival-of-a-patient-with-the-mixed-adeno-neuroendocrine-bile-duct-carcinoma-a-case-report-and-review-of-the-literature
#1
Wataru Izumo, Ryota Higuchi, Takehisa Yazawa, Shuichiro Uemura, Yutaro Matsunaga, Masahiro Shiihara, Toru Furukawa, Masakazu Yamamoto
INTRODUCTION: Neuroendocrine tumors arising primarily in the bile duct are rare. And among these tumors, mixed adeno-neuroendocrine carcinoma (MANEC) is quite uncommon. We report a patient with MANEC who achieved long-term recurrence-free survival. And our case report includes analysis previous case reports. PRESENTATION OF CASE: A 66-year-old man underwent investigation for persistent anorexia and fatigue. Laboratory tests showed that the values of hepatobiliary enzymes were increased...
August 4, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28796833/bile-microbiota-in-primary-sclerosing-cholangitis-impact-on-disease-progression-and-development-of-biliary-dysplasia
#2
Pedro Pereira, Velma Aho, Johanna Arola, Sonja Boyd, Kalle Jokelainen, Lars Paulin, Petri Auvinen, Martti Färkkilä
OBJECTIVE: The etiopathogenesis and risk for development of biliary neoplasia in primary sclerosing cholangitis (PSC) are largely unknown. Microbes or their metabolites have been suggested to play a role. To explore this potential microbial involvement, we evaluated the differences in biliary microbiota in PSC patients at an early disease stage without previous endoscopic retrograde cholangiography (ERC) examinations, advanced disease stage, and with biliary dysplasia or cholangiocarcinoma...
2017: PloS One
https://www.readbyqxmd.com/read/28796653/surgical-treatment-of-colon-cancer-of-the-splenic-flexure-a-systematic-review-and-meta-analysis
#3
Aleix Martínez-Pérez, Francesco Brunetti, Giulio C Vitali, Solafah Abdalla, Frédéric Ris, Nicola de'Angelis
This is a systematic review and meta-analysis on the surgical treatments of splenic flexure carcinomas (SFCs). Medline, EMBASE, and Scopus were searched from January 1990 to May 2016. Studies of at least 5 patients comparing extended right colectomy (ERC) versus left colectomy (LC) and/or laparoscopy versus open surgery for SFCs were retrieved and analyzed. Overall, 12 retrospective studies were selected, including 569 patients. ERC was performed in 23.2% of patients, whereas LC in 76.8%. Pooled data suggested that ERC and LC had similar oncologic quality of resection and postoperative outcomes...
August 7, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28752156/accounting-for-the-confound-of-meninges-in-segmenting-entorhinal-and-perirhinal-cortices-in-t1-weighted-mri
#4
Long Xie, Laura E M Wisse, Sandhitsu R Das, Hongzhi Wang, David A Wolk, Jose V Manjón, Paul A Yushkevich
Quantification of medial temporal lobe (MTL) cortices, including entorhinal cortex (ERC) and perirhinal cortex (PRC), from in vivo MRI is desirable for studying the human memory system as well as in early diagnosis and monitoring of Alzheimer's disease. However, ERC and PRC are commonly over-segmented in T1-weighted (T1w) MRI because of the adjacent meninges that have similar intensity to gray matter in T1 contrast. This introduces errors in the quantification and could potentially confound imaging studies of ERC/PRC...
October 2016: Medical Image Computing and Computer-assisted Intervention: MICCAI ..
https://www.readbyqxmd.com/read/28664681/tuning-the-composition-of-bimetallic-electrodeposited-sn-pb-catalysts-for-enhanced-activity-and-durability-in-co2-electroreduction-to-formate
#5
Elod Gyenge, Colin Moore
Bimetallic Sn-Pb catalysts with five different Sn:Pb atomic ratios were electrodeposited on teflonated carbon paper and un-teflonated carbon cloth using both fluoroborate and oxide containing deposition media to produce catalysts for electrochemical reduction of CO2 (ERC) to formate (HCOO-). The interaction between catalyst composition, morphology, substrate and deposition media was investigated by cyclic voltammetry and constant potential electrolysis at -2.0 V vs. Ag/AgCl for 2 h in 0.5 M KHCO3. The catalysts were analyzed before and after electrolysis with scanning electron microscopy (SEM) and X-ray diffraction (XRD) to determine the mechanisms of faradaic efficiency loss and degradation...
June 29, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28664637/author-s-response-endoscopic-biodegradable-biliary-stents-in-the-treatment-of-benign-biliary-strictures-the-first-report-in-clinical-use-in-patients-antti-siiki-irina-rinta-kiikka-and-johanna-laukkarinen
#6
Antti Siiki, Irina Rinta-Kiikka, Johanna Laukkarinen
We appreciate the comments of Dr. Koksal and co-workers on our recent article. In brief, we reported on two first patients with benign biliary strictures treated with self-expanding poly-dioxanone biodegradable biliary stents (BDBS) inserted in endoscopic retrograde cholangiography (ERC). The authors underline that BDBS may cause epithelial hyperplasia in the bile duct similarly to oesophageal use. This article is protected by copyright. All rights reserved.
June 30, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28656800/position-paper-on-management-of-iron-deficiency-in-adult-cancer-patients
#7
Sandro Barni, Pere Gascòn, Fausto Petrelli, José Antonio García-Erce, Paolo Pedrazzoli, Giovanni Rosti, Giulio Giordano, Antonio Mafodda, Manuel Múñoz
Disorders of iron metabolism are commonly seen in onco-hematological clinical practice. Iron-deficiency anemia and cancer-associated anemia are usually treated with supportive therapies. Optimal management of these conditions are discussed in this perspective paper. Areas covered: A position paper discussing a number of hot topics on anemia in cancer patients is presented. The main areas covered by experts in the field are: definitions, prevalence and consequences of anemia and iron deficiency, incidence of anemia resulting from targeted therapies, importance of anemia diagnosis and monitoring, evaluation of iron status before and during treatment, role of transfusions and erythropoiesis-stimulating agents, management of iron deficiency with or without anemia, parenteral iron supplementation, role of new oral iron formulations, safety and cost issues regarding different iron compounds and administration routes...
July 3, 2017: Expert Review of Hematology
https://www.readbyqxmd.com/read/28652965/a-protocol-for-manual-segmentation-of-medial-temporal-lobe-subregions-in-7%C3%A2-tesla-mri
#8
D Berron, P Vieweg, A Hochkeppler, J B Pluta, S-L Ding, A Maass, A Luther, L Xie, S R Das, D A Wolk, T Wolbers, P A Yushkevich, E Düzel, L E M Wisse
Recent advances in MRI and increasing knowledge on the characterization and anatomical variability of medial temporal lobe (MTL) anatomy have paved the way for more specific subdivisions of the MTL in humans. In addition, recent studies suggest that early changes in many neurodegenerative and neuropsychiatric diseases are better detected in smaller subregions of the MTL rather than with whole structure analyses. Here, we developed a new protocol using 7 Tesla (T) MRI incorporating novel anatomical findings for the manual segmentation of entorhinal cortex (ErC), perirhinal cortex (PrC; divided into area 35 and 36), parahippocampal cortex (PhC), and hippocampus; which includes the subfields subiculum (Sub), CA1, CA2, as well as CA3 and dentate gyrus (DG) which are separated by the endfolial pathway covering most of the long axis of the hippocampus...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28651650/ethics-review-of-studies-during-public-health-emergencies-the-experience-of-the-who-ethics-review-committee-during-the-ebola-virus-disease-epidemic
#9
Emilie Alirol, Annette C Kuesel, Maria Magdalena Guraiib, Vânia de la Fuente-Núñez, Abha Saxena, Melba F Gomes
BACKGROUND: Between 2013 and 2016, West Africa experienced the largest ever outbreak of Ebola Virus Disease. In the absence of registered treatments or vaccines to control this lethal disease, the World Health Organization coordinated and supported research to expedite identification of interventions that could control the outbreak and improve future control efforts. Consequently, the World Health Organization Research Ethics Review Committee (WHO-ERC) was heavily involved in reviews and ethics discussions...
June 26, 2017: BMC Medical Ethics
https://www.readbyqxmd.com/read/28651227/double-cystic-duct-preoperatively-diagnosed-and-successfully-treated-with-laparoscopic-cholecystectomy-a-case-report
#10
Atsushi Fujii, Masatsugu Hiraki, Noriyuki Egawa, Hiroshi Kono, Takao Ide, Junichi Nojiri, Junji Ueda, Hiroyuki Irie, Hirokazu Noshiro
INTRODUCTION: A single gallbladder with a double cystic duct is a very rare finding. In addition, few cases with this rare condition are preoperatively diagnosed. However, the preoperative confirmation or suspicion of this rare condition could facilitate safe laparoscopic cholecystectomy, which is a minimally invasive therapeutic modality for gallbladder disease. We herein present a case of gallstone disease in a patient with a double cystic duct who was preoperatively diagnosed and successfully treated with laparoscopic cholecystectomy...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28643322/difficulties-in-funding-of-va-ecmo-therapy-for-patients-with-severe-accidental-hypothermia
#11
Sylweriusz Kosiński, Tomasz Darocha, Anna Jarosz, Aleksandra Czerw, Paweł Podsiadło, Tomasz Sanak, Robert Gałązkowski, Jacek Piątek, Janusz Konstanty-Kalandyk, Mirosław Ziętkiewicz, Krzysztof Kusza, Łukasz J Krzych, Rafał Drwiła
BACKGROUND: Severe accidental hypothermia is defined as a core temperature below 28 Celsius degrees. Within the last years, the issue of accidental hypothermia and accompanying cardiac arrest has been broadly discussed and European Resuscitation Council (ERC) Guidelines underline the importance of Extracorporeal Rewarming (ECR) in treatment of severely hypothermic victims. The study aimed to evaluate the actual costs of ECR with VA-ECMO and of further management in the Intensive Care Unit of patients admitted to the Severe Accidental Hypothermia Centre in Cracow, Poland...
2017: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/28629343/comparative-effectiveness-research-what-to-do-when-experts-disagree-about-risks
#12
Reidar K Lie, Francis K L Chan, Christine Grady, Vincent H Ng, David Wendler
BACKGROUND: Ethical issues related to comparative effectiveness research, or research that compares existing standards of care, have recently received considerable attention. In this paper we focus on how Ethics Review Committees (ERCs) should evaluate the risks of comparative effectiveness research. MAIN TEXT: We discuss what has been a prominent focus in the debate about comparative effectiveness research, namely that it is justified when "nothing is known" about the comparative effectiveness of the available alternatives...
June 19, 2017: BMC Medical Ethics
https://www.readbyqxmd.com/read/28626827/the-effect-of-rapid-privatisation-on-mortality-in-mono-industrial-towns-in-post-soviet-russia-a-retrospective-cohort-study
#13
Aytalina Azarova, Darja Irdam, Alexi Gugushvili, Mihaly Fazekas, Gábor Scheiring, Pia Horvat, Denes Stefler, Irina Kolesnikova, Vladimir Popov, Ivan Szelenyi, David Stuckler, Michael Marmot, Michael Murphy, Martin McKee, Martin Bobak, Lawrence King
BACKGROUND: Population-level data suggest that economic disruptions in the early 1990s increased working-age male mortality in post-Soviet countries. This study uses individual-level data, using an indirect estimation method, to test the hypothesis that fast privatisation increased mortality in Russia. METHODS: In this retrospective cohort study, we surveyed surviving relatives of individuals who lived through the post-communist transition to retrieve demographic and socioeconomic characteristics of their parents, siblings, and male partners...
May 2017: Lancet. Public Health
https://www.readbyqxmd.com/read/28622530/brain-network-dynamics-in-the-human-articulatory-loop
#14
Masaaki Nishida, Anna Korzeniewska, Nathan E Crone, Goichiro Toyoda, Yasuo Nakai, Noa Ofen, Erik C Brown, Eishi Asano
OBJECTIVE: The articulatory loop is a fundamental component of language function, involved in the short-term buffer of auditory information followed by its vocal reproduction. We characterized the network dynamics of the human articulatory loop, using invasive recording and stimulation. METHODS: We measured high-gamma activity70-110 Hz recorded intracranially when patients with epilepsy either only listened to, or listened to and then reproduced two successive tones by humming...
August 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28597104/-upper-abdominal-pain-nausea-and-vomiting-in-a-63-year-old-woman
#15
S Schwarzer, K Rapis
We present a case of myotonic dystrophy type I and its complications including cholangitis and cardiac arrhythmias. The therapy options focus on the consequences of the disease and result in an endoscopic retrograde cholangiography (ERC) and implantation of an implantable cardioverter-defibrillator (ICD). Myotonic dystrophy is a disease which results in a loss of smooth and skeletal muscle cells leading to multiple consequences such as gastrointestinal symptoms and cardiac manifestations.
June 8, 2017: Der Internist
https://www.readbyqxmd.com/read/28586081/bed%C3%A3-mning-av-neuro%C3%A2-logisk-prognos-efter-hj%C3%A3-rtstopp-uppdaterade-rekommendationer-fr%C3%A3-n-svenska-hlr-r%C3%A3-dets-expertgrupp
#16
Christian Rylander, Hans Friberg, Elna-Marie Larsson, Lars Johan Liedholm, Sten Rubertsson, Tobias Cronberg
Assessment of neurologic prognosis after cardiac arrest. Updated recommendations from the Swedish CPR Council Expert Group European Resuscitation Council (ERC) issued updated guidelines for postresuscitation care in 2015. This paper provides updated Swedish recommendations for neurological prognostication of patients remaining unconscious after cardiac arrest (CA). The prognostication should be based on independent methods; clinical and neurophysiological examinations, imaging and biomarkers. It should not be performed earlier than three days after CA and any influence from sedatives must be negligible...
June 2, 2017: Läkartidningen
https://www.readbyqxmd.com/read/28585854/abordaje-nutricional-del-paciente-con-diabetes-mellitus-e-insuficiencia-renal-cr%C3%A3-nica-a-prop%C3%A3-sito-de-un-caso
#17
Beatriz Torres Torres, Olatz Izaola Jáuregu, Daniel A De Luis Román
La prevención y el tratamiento de la enfermedad renal crónica (ERC) en pacientes con diabetes ha sido un tema de gran interés a lo largo de los años. Para conseguir un adecuado control glucémico, una función renal estable y una reducción del riesgo cardiovascular, es fundamental un correcto aporte de hidratos de carbono, lípidos y proteínas. Las medidas dietéticas realizadas se irán modificando a lo largo de la evolución de la ERC. La malnutrición energético-proteica es muy frecuente en pacientes con ERC y diabetes y es un importante predictor de morbimortalidad...
May 8, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28545474/a-retrospective-study-to-assess-the-evaluation-of-living-related-kidney-donors-and-their-outcomes-following-nephrectomy-at-kenyatta-national-hospital
#18
A Muturi, V Kotecha, S Kanyi
BACKGROUND: Kidney transplantation is the renal replacement therapy of choice for end stage renal disease. To ensure safety regular audit of the donation process is necessary. The aim of this study was to assess the evaluation of potential living related kidney donors and document their outcomes following nephrectomy. METHODS: This was a retrospective descriptive study involving all living related kidney donors seen at Kenyatta National Hospital (KNH) renal unit from 2010 to 2014...
May 25, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28541549/cognitive-development-in-children-up-to-age-11-years-born-after-art-a-longitudinal-cohort-study
#19
Anna Barbuscia, Melinda C Mills
STUDY QUESTION: How does the cognitive development of children conceived after ART (IVF and ICSI) - measured as cognitive skills at age 3, 5, 7 and 11 years - differ over time from those born after natural conception (NC)? SUMMARY ANSWER: Improved measures of cognitive development up to age 5 years were recorded in children conceived with ART compared to NC, which attenuates by 11 years, with ART children still scoring slightly better than NC children. WHAT IS KNOWN ALREADY: Results on the cognitive outcomes of children conceived after ART have been highly contradictory...
May 24, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28507330/flatbed-epi-relief-contrast-cellular-monitoring-system-for-stable-cell-culture
#20
Tatsuya Osaki, Tatsuto Kageyama, Yuka Shimazu, Dina Mysnikova, Shintaro Takahashi, Shinichi Takimoto, Junji Fukuda
Consistent cell preparation is a fundamental preliminary step for understanding complex cellular mechanisms in various cell-based research fields, including basic cell biology, cancer research, and tissue engineering. However, certain elusive factors, such as cellular de-differentiation and contamination with mycoplasma or other types of cells, have compromised the reproducibility and reliability of cell-based approaches. Here, we propose an epi relief-contrast cellular monitoring system (eRC-CMS) that allows images of cells in a typical culture plate to be acquired, stored, and analysed for daily cell quality control...
May 15, 2017: Scientific Reports
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