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https://www.readbyqxmd.com/read/29786893/primary-cystic-duct-carcinoma-diagnosed-by-targeted-biopsy-with-digital-cholangioscopy
#1
Masaki Miyazawa, Shogo Matsuda, Uichiro Fuchizaki
A 79-year-old man was introduced to our hospital for obstructive jaundice. Computed tomography (CT) showed the stricture of the common bile duct (CBD) and the cystic duct (CD) (Fig. 1). Suspicious diagnosis was cholangiocarcinoma. Endoscopic retrograde cholangiography (ERC) showed the stricture of the CBD and the CD dilatation. This article is protected by copyright. All rights reserved.
May 22, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29784012/treatment-of-experimental-colitis-by-endometrial-regenerative-cells-through-regulation-of-b-lymphocytes-in-mice
#2
Xiaoxi Xu, Yong Wang, Baoren Zhang, Xu Lan, Shanzheng Lu, Peng Sun, Xiang Li, Ganggang Shi, Yiming Zhao, Hongqiu Han, Caigan Du, Hao Wang
BACKGROUND: Endometrial regenerative cells (ERCs), a novel type of mesenchymal-like stem cell derived from menstrual blood, have been recently evaluated as an attractive candidate source in ulcerative colitis (UC); however, the mechanism is not fully understood. The present study was designed to investigate the effects of ERCs, especially on B-cell responses in UC. METHODS: In this study, colitis was induced by administering 3% dextran sodium sulfate (DSS) via free drinking water for 7 days to BALB/c mice...
May 22, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29774134/an-undifferentiated-carcinoma-at-klatskin-position-with-long-term-complete-remission-after-chemotherapy
#3
Bruno Christian Köhler, Benjamin Goeppert, Nina Waldburger, Kai Schlamp, Peter Sauer, Dirk Jäger, Karl Heinz Weiss, Stephan Macher-Göppinger, Henning Schulze-Bergkamen, Peter Schirmacher, Christoph Springfeld
Background: Neoplasms anatomically adjacent to the bile duct usually derive from malignantly transformed cholangiocytes forming cholangiocarcinoma (CCA). CCAs are divided in extrahepatic (eCCA) and intrahepatic (iCCA) tumors. Patients with irresectable CCAs are treated with systemic chemotherapy and have an unfavorable prognosis with a median survival of about one year. Here, we report a case of an undifferentiated carcinoma in Klatskin-position with long-term remission after systemic chemotherapy...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29731774/b7-h1-expression-is-required-for-human-endometrial-regenerative-cells-in-the-prevention-of-transplant-vasculopathy-in-mice
#4
Kui Ye, Xu Lan, Grace Wang, Baoren Zhang, Xiaoxi Xu, Xiang Li, Yiming Zhao, Hao Wang
Vasculopathy is one of the primary pathological changes in chronic rejection of vascularized allograft transplantation. Endometrial regenerative cells (ERCs) are mesenchymal-like stromal cells with immunosuppressive effect. B7-H1 is a negative costimulator that mediates active immune suppression. The aim of this study was to investigate the requirement of B7-H1 in the immunoregulation of ERCs in preventing transplant vasculopathy of aorta allografts. The results showed that B7-H1 expression on ERCs was upregulated by IFN- γ in a dose-dependent manner and it was required for ERCs to inhibit the proliferation of peripheral blood mononuclear cells (PBMCs) in vitro ...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29729226/eus-guided-hepaticoenterostomy-as-a-portal-to-allow-definitive-antegrade-treatment-of-benign-biliary-diseases-in-patients-with-surgically-altered-anatomy
#5
Theodore W James, Y Claire Fan, Todd H Baron
BACKGROUND & AIMS: EUS-guided hepaticoenterostomy (EUS-HE) is usually reserved for palliation of malignant biliary obstruction after failed endoscopic retrograde cholangiography (ERC) or inaccessible biliary tree in surgically altered anatomy (SAA). We describe outcome of EUS-HE and antegrade therapy for benign biliary disease in patients with SAA. METHODS: Retrospective review of 20 consecutive patients with surgically altered anatomy and benign biliary obstruction who underwent EUS-HE performed by one endoscopist at a tertiary center over a three-year period...
May 2, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29714431/emotion-regulation-and-premedication-success-relationship-in-children-who-underwent-general-anesthesia
#6
Aslıhan Aykut, Berrin Işık
Background/aim: This study aims to investigate the relationship between emotion regulation characteristics and the efficacy of midazolam premedication. Materials and methods: Sixty-three children, aged 3 to 8 years old, with tonsillectomy and/or adenoidectomy and taking premedication with midazolam (Group 2) or without premedication (Group 1), were included in this study. The behavioral and emotional status of the children was evaluated with the Conners Parent Rating Scale-48 (CPRS-48) and Emotion Regulation Checklist (ERC)...
April 30, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29709454/are-there-differences-between-women-who-choose-elective-repeat-caesarean-versus-trial-of-labour-in-st-john-s-nl
#7
Paul Groves, Joannie Neveu, Colleen Cook, Phil Murphy, Joan M G Crane
OBJECTIVES: To compare the demographic and clinical characteristics between women who chose elective repeat Caesarean section (ERCS) versus trial of labour after Caesarean section (TOLAC) in St. John's, Newfoundland and Labrador (NL). METHODS: We conducted a retrospective case control study of women with live singleton gestations delivering at term in St. John's, NL between January 1, 2001 and December 31, 2014. Inclusion criteria were women who had a previous single lower segment Caesarean section (LSCS)...
April 27, 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29701844/substituting-ground-woody-plants-for-cottonseed-hulls-in-kid-goat-feedlot-diets-growth-performance-and-blood-serum-chemistry
#8
J L Glasscock, T R Whitney, J R Navarro, S G Angle, A R Holmes, W C Stewart, E J Scholljegerdes
Boer × Spanish kid goats (n = 48) were used to evaluate effects of using ground woody products in feedlot diets on growth performance and blood serum chemistry. A completely randomized study design was used with two feeding periods (Period 1 = 70% concentrate, d 0 to 26; Period 2 = 86% concentrate, d 27 to 64). Goats were individually fed 1 of 6 diets that differed only by roughage source (n = 4 wether males and 4 females/treatment; initial BW = 22 ± 2 kg): cottonseed hulls (CSH; control) or ground wood consisting of redberry (RED), blueberry (BLUE), one-seed (ONE), or eastern red cedar (ERC) Juniperus spp...
April 26, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29691060/from-blood-saving-programs-to-ptient-blood-management-and-beyond
#9
Javier Ripollés-Melchor, Carlos Jericó-Alba, Manuel Quintana-Díaz, José Antonio García-Erce
No abstract text is available yet for this article.
April 21, 2018: Medicina Clínica
https://www.readbyqxmd.com/read/29690612/neuroprotective-and-anti-inflammatory-effects-of-rhus-coriaria-extract-in-a-mouse-model-of-ischemic-optic-neuropathy
#10
Saba Khalilpour, Ghazaleh Behnammanesh, Fouad Suede, Mohammed O Ezzat, Jayadhisan Muniandy, Yasser Tabana, Mohamed Khadeer Ahamed, Ali Tamayol, Amin Malik Shah Majid, Enrico Sangiovanni, Mario Dell'Agli, Aman Shah Majid
Modulating oxidative stresses and inflammation can potentially prevent or alleviate the pathological conditions of diseases associated with the nervous system, including ischemic optic neuropathy. In this study we evaluated the anti-neuroinflammatory and neuroprotective activities of Rhus coriaria ( R. coriaria) extract in vivo. The half maximal inhibitory concentration (IC50 ) for DPPH, ABTS and β⁻carotene were 6.79 ± 0.009 µg/mL, 10.94 ± 0.09 µg/mL, and 6...
April 23, 2018: Biomedicines
https://www.readbyqxmd.com/read/29685628/antegrade-papillotome-navigation-as-a-novel-next-line-approach-for-internalization-of-percutaneous-transhepatic-biliary-drainage
#11
V Zimmer
There is an increasing rivalry between percutaneous transhepatic (PTBD) vs. endoscopic ultrasound-guided biliary drainage (EUS-BD) as rescue techniques after failed endoscopic retrograde cholangiography (ERC) access. While EUS-BD procedures hold a bright future, innovations in PTBD technique are still possible and clinically meaningful, at least so, under the a conceptual framework understanding PTBD as a bridging, anatomy-respecting technology for definitive biliary metal stenting. This, however, calls for successful PTBD internalization as a sine qua non...
April 20, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29672825/estimating-success-of-vaginal-birth-after-caesarean-section-in-a-regional-australian-population-validation-of-a-prediction-model
#12
Samantha S Mooney, Richard Hiscock, Inkeri D'Arcy Clarke, Simon Craig
BACKGROUND: Following a primary caesarean section (CS), women must decide between attempted vaginal birth after caesarean (VBAC) and elective repeat caesarean section (ERCS) in subsequent pregnancies. Both options carry potential morbidity and mortality for mother and child, with the most feared being uterine rupture and its consequences. In attempts to reduce morbidity, several predictive nomograms have been developed to assist in delivery mode decisions. AIM: To assess the validity of the predictive nomogram developed by Grobman et al...
April 19, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29668012/evolution-of-dnmt2-in-drosophilids-evidence-for-positive-and-purifying-selection-and-insights-into-new-protein-pathways-interactions
#13
Gilberto Cavalheiro Vieira, Marícia Fantinel D'Ávila, Rebeca Zanini, Maríndia Deprá, Vera Lúcia da Silva Valente
The DNA methyltransferase 2 (DNMT2) protein is the most conserved member of the DNA methyltransferase family. Nevertheless, its substrate specificity is still controversial and elusive. The genomic role and determinants of DNA methylation are poorly understood in invertebrates, and several mechanisms and associations are suggested. In Drosophila, the only known DNMT gene is Dnmt2. Here we present our findings from a wide search for Dnmt2 homologs in 68 species of Drosophilidae. We investigated its molecular evolution, and in our phylogenetic analyses the main clades of Drosophilidae species were recovered...
2018: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29657065/transfusion-thresholds-and-red-blood-cells-transfusion-focused-on-tissue-oxygenation
#14
J Ripollés-Melchor, J A García-Erce, J-L Vincent
No abstract text is available yet for this article.
April 12, 2018: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/29621972/trawlerweb-an-online-de-novo-motif-discovery-tool-for-next-generation-sequencing-datasets
#15
Louis T Dang, Markus Tondl, Man Ho H Chiu, Jerico Revote, Benedict Paten, Vincent Tano, Alex Tokolyi, Florence Besse, Greg Quaife-Ryan, Helen Cumming, Mark J Drvodelic, Michael P Eichenlaub, Jeannette C Hallab, Julian S Stolper, Fernando J Rossello, Marie A Bogoyevitch, David A Jans, Hieu T Nim, Enzo R Porrello, James E Hudson, Mirana Ramialison
BACKGROUND: A strong focus of the post-genomic era is mining of the non-coding regulatory genome in order to unravel the function of regulatory elements that coordinate gene expression (Nat 489:57-74, 2012; Nat 507:462-70, 2014; Nat 507:455-61, 2014; Nat 518:317-30, 2015). Whole-genome approaches based on next-generation sequencing (NGS) have provided insight into the genomic location of regulatory elements throughout different cell types, organs and organisms. These technologies are now widespread and commonly used in laboratories from various fields of research...
April 5, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29605787/basic-life-support-and-external-defibrillation-competences-after-instruction-and-at-6-months-comparing-face-to-face-and-blended-training-randomised-trial
#16
Jordi Castillo, Aberto Gallart, Encarnación Rodríguez, Jorge Castillo, Carmen Gomar
AIM OF THE STUDY: The objective of this study was to compare the immediate and 6-month efficacy of basic life support (BLS) and automatic external defibrillation (AED) training using standard or blended methods. METHODS: First-year students of medicine and nursing (n = 129) were randomly assigned to a control group (face-to-face training based on the European Resuscitation Council [ERC] Guidelines) or to an experimental group that trained with a self-training video, a new website, a Moodle platform, an intelligent manikin, and 45 min of instructor presence...
March 24, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29576820/the-emergency-department-crash-cart-a-systematic-review-and-suggested-contents
#17
REVIEW
Gabrielle A Jacquet, Bachar Hamade, Karim A Diab, Rasha Sawaya, Gilbert Abou Dagher, Eveline Hitti, Jamil D Bayram
BACKGROUND: As the field of Emergency Medicine grows worldwide, the importance of an Emergency Department Crash Cart (EDCC) has long been recognized. Yet, there is paucity of relevant peer-reviewed literature specifically discussing EDCCs or proposing detailed features for an EDCC suitable for both adult and pediatric patients. METHODS: The authors performed a systematic review of EDCC-specific literature indexed in Pubmed and Embase on December 20, 2016. In addition, the authors reviewed the 2015 American Heart Association (AHA) guidelines for cardiopulmonary resuscitation and emergency cardiovascular care, the 2015 European Resuscitation Council (ERC) guidelines for resuscitation, and the 2013 American College of Surgeons (ACS) Advanced Trauma Life Support (ATLS) 9th edition...
2018: World Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29575243/a-direct-cholangioscopic-perspective-on-cholecystitis
#18
Vincent Zimmer, Ernst-Peter Mues
Putrid drainage during endoscopic retrograde cholangiography (ERC) is usually considered equivalent to ongoing cholangitis, however, acute cholecystitis representing a viable alternative diagnosis ("not all that drains pus is cholangitis"). Endoscopic high-quality visualization by direct cholangioscopy (DC) of acute cholecystitis has not been been reported so far, while mimimal information is available in such context pertaining to therapeutic single-operator cholangioscopy (SOC)-assisted gallbladder drainage...
March 25, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29573754/beyond-the-limits-ecpr-in-putative-fatal-circumstances
#19
Ingo Graeff, Sylvia Schacher, Stefan Lenkeit, Catherine N Widmann, Jens-Christian Schewe
The eligibility criteria for applying extracorporeal cardiopulmonary resuscitation (ECPR) in patients with cardiac arrest are currently unclear. For those patients with hypothermic cardiac arrest, the European Resuscitation Council (ERC) Guidelines recommend considering ECPR only for patients with potassium <8 mmol/L and a body temperature below 32°C, whereas the American Heart Association Guidelines (AHA) do not express this in a specific manner. We report the case of an urban unwitnessed out-of-hospital cardiac arrest patient found with her head immersed in water at a temperature of 23°C...
March 25, 2018: CJEM
https://www.readbyqxmd.com/read/29562417/-experiences-of-esophageal-replacement-with-ileocolon-graft-a-series-of-34-cases
#20
X F Guo, R Hua, Y F Sun, Y Yang, B Ye, B Li, H Y Gu, X B Zhang, T Mao, Z G Li
Objective: To evaluate the safety and effectiveness of esophageal replacement with ileocolon graft. Methods: Totally 34 cases of esophageal replacement with ileocolon graft from July 2015 to November 2017 at Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong University were analyzed retrospectively, including 24 male and 10 female, aging from 7 to 72 years old. Esophageal replacement with ileocolon graft by right and/or middle colic artery as a blood supply using retrosternal route except one subcutaneous route...
April 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
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