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Fernando J Sialana, Peter Gulyassy, Peter Májek, Evelina Sjöstedt, Viktor Kis, André C Müller, Elena L Rudashevskaya, Jan Mulder, Keiryn L Bennett, Gert Lubec
The molecular composition of synaptic signal transduction machineries shapes synaptic neurotransmission. The repertoire of receptors, transporters and channels (RTCs) comprises major signaling events in the brain. RTCs are conventionally studied by candidate immunohistochemistry and biochemistry, which are low throughput with resolution greatly affected by available immunoreagents and membrane interference. Therefore, a comprehensive resource of synaptic brain RTCs is still lacking. In particular, studies on the detergent-soluble synaptosomal fraction, known to contain transporters and channels, are limited...
October 19, 2016: Proteomics
Fernando G Benavides, Pamela Merino-Salazar, Cecilia Cornelio, Ada Avila Assunção, Andrés A Agudelo-Suárez, Marcelo Amable, Lucía Artazcoz, Jonh Astete, Douglas Barraza, Fabián Berhó, Lino Carmenate Milián, George Delclòs, Lorena Funcasta, Johanna Gerke, David Gimeno, María José Itatí-Iñiguez, Eduardo de Paula Lima, David Martínez-Iñigo, Adriane Mesquita de Medeiros, Lida Orta, Javier Pinilla, Fernando Rodrigo, Marianela Rojas, Iselle Sabastizagal, Clelia Vallebuona, Greet Vermeylen, Gloria H Villalobos, Alejandra Vives
This article aimed to present a basic questionnaire and minimum methodological criteria for consideration in future Surveys on Working Conditions, Employment, and Health in Latin America and the Caribbean. A virtual and face-to-face consensus process was conducted with participation by a group of international experts who used the surveys available up until 2013 as the point of departure for defining the proposal. The final questionnaire included 77 questions grouped in six dimensions: socio-demographic characteristics of workers and companies; employment conditions; working conditions; health status; resources and preventive activities; and family characteristics...
October 10, 2016: Cadernos de Saúde Pública
Otto Mauro Dos Santos-Rosa, Henrique Simonsen Lunardelli, Marcelo Augusto Fontenelle Ribeiro-Junior
Background: The pyogenic liver abscess has an incidence of 1.1/1,000 habitants. Mortality can reach 100%. The use of less invasive procedures diminish morbidity and hospital stay. Aim: Identify risk factors in patients who underwent percutaneous drainage guided by ultrasound as treatment. Method: Were analyzed 10 patients submitted to the method. Epidemiological characteristics, laboratory markers and imaging exams (ultrasound and CT) were evaluated...
July 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
Shoaib Faruqi, Nalla Kishore, Richard Bodington, Salim Meghjee, Muthu Thirumaran
AIMS: In this retrospective study we assess the diagnostic yield of computed tomography pulmonary angiogram (CTPA) and the incidence of alterative and incidental diagnoses. METHODS: The results of all CTPA scans performed in our trust over a period of 18 months were reviewed and all diagnoses noted. Data collected was descriptively analysed. RESULTS: A total of 1138 scans were performed (56.5% men, mean age 59 years). A diagnosis of pulmonary embolism (PE) was made in 20...
2016: Acute Medicine
(no author information available yet)
No abstract text is available yet for this article.
November 2016: Nursing
Francesco Cavallin, Marco Scarpa, Matteo Cagol, Rita Alfieri, Alberto Ruol, Vanna Chiarion Sileni, Ermanno Ancona, Carlo Castoro
OBJECTIVE: The aim of this study was to investigate trends in patients' characteristics and comorbidities in esophageal cancer (EC) patients. BACKGROUND: Identifying changing pattern is essential to understand and predict further changes and to plan surgical procedures and resource allocation. METHODS: Trends in patients' characteristics and comorbidities were evaluated in 4440 EC patients at the Center for Esophageal Diseases in Padova, Italy, during 1980 to 2011...
October 17, 2016: Annals of Surgery
Talia Orr, Marsha Campbell-Yeo, Britney Benoit, Brenda Hewitt, Jennifer Stinson, Patrick McGrath, Donna Dowling
BACKGROUND: Despite an abundance of research that identifies the benefits for both parent and child when parents are actively involved in their infant's care, challenges related to the best methods to engage families persist. PURPOSE: To conduct a feasibility study that aims to understand the preferences of smartphone and Internet use by parents of infants admitted to the neonatal intensive care unit (NICU) related to information seeking and active participation in infant care, with a focus on pain management interventions...
October 18, 2016: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
Debbie Laliberte Rudman, Deborah Gold, Colleen McGrath, Biljana Zuvela, Marlee M Spafford, Rebecca Renwick
Social participation, a key determinant of healthy aging, is often negatively impacted by age-related vision loss (ARVL). This grounded theory study aimed to understand social participation as a process negotiated in everyday life by older adults with ARVL. Interviews, audio diaries, and life space maps were used to collect data with 21 older adults in two Ontario cities. Inductive data analysis resulted in a transactional model of the process of negotiating social participation in context. This model depicts how environmental features and resources, skills and abilities, and risks and vulnerabilities transacted with values and priorities to affect if and how social participation occurred within the context of daily life...
October 18, 2016: Canadian Journal on Aging, la Revue Canadienne du Vieillissement
David B Nicholas, Sandra Hodgetts, Lonnie Zwaigenbaum, Leann E Smith, Paul Shattuck, Jeremy R Parr, Olivia Conlon, Tamara Germani, Wendy Mitchell, Lori Sacrey, Margot E Stothers
Research related to supports for adults with autism spectrum disorder (ASD) is under-developed. As an example, system and service development to support successful transition to adulthood and meaningful vocation for adults has received relatively little research scrutiny until recently, with practitioners and program developers lacking evidence-informed approaches guiding service delivery. A Special Interest Group (SIG) was convened at the International Meeting for Autism Research in May 2014 and May 2015, with a focus on transitional and vocational issues in ASD...
October 17, 2016: Autism Research: Official Journal of the International Society for Autism Research
Mareike Cora Janiak
All living organisms need to consume nutrients to grow, survive, and reproduce, making the successful acquisition of food resources a powerful selective pressure. However, acquiring food is only part of the challenge. While all animals spend much of their daily activity budget hunting, searching for, or otherwise procuring food, a large part of what is involved in overall nutrition occurs once the meal has been swallowed. Most nutritional components are too complex for immediate use and must be broken down into simpler compounds, which can then be absorbed by the body...
September 2016: Evolutionary Anthropology
Christine H Stortini, Denis Chabot, Nancy L Shackell
We have learned much about the impacts of warming on the productivity and distribution of marine organisms, but less about the impact of warming combined with other environmental stressors, including oxygen depletion. Also, the combined impact of multiple environmental stressors requires evaluation at the scales most relevant to resource managers. We use the Gulf of St. Lawrence, Canada, characterized by a large permanently hypoxic zone, as a case study. Species Distribution Models were used to predict the impact of multiple scenarios of warming and oxygen depletion on the local density of three commercially and ecologically important species...
October 18, 2016: Global Change Biology
Stefanie Doebler, Assumpta Ryan, Sally Shortall, Aideen Maguire
Informal care-giving can be a demanding role which has been shown to impact on physical, psychological and social well-being. Methodological weaknesses including small sample sizes and subjective measures of mental health have led to inconclusive evidence about the relationship between informal care-giving and mental ill-health. This paper reports on a study carried out in a UK region which investigated the relationship between informal care-giving and mental ill-health. The analysis was conducted by linking three data sets, the Northern Ireland Longitudinal Study, the Northern Ireland Enhanced Prescribing Database and the Proximity to Service Index from the Northern Ireland Statistics and Research Agency...
October 18, 2016: Health & Social Care in the Community
Michael Bobian, Aron Kandinov, Nour El-Kashlan, Peter F Svider, Adam J Folbe, Ross Mayerhoff, Jean Anderson Eloy, S Naweed Raza
OBJECTIVES/HYPOTHESIS: Despite the increasing role of mobile applications (apps) in patient education, there has been little inquiry evaluating the quality of these resources. Because poor health literacy has been associated with inferior health outcomes, evaluating the quality of patient education materials takes on great importance. Our objective was to employ validated readability tools for the evaluation of gastroesophageal reflux (GERD) mobile apps. METHODS: GERD-specific apps found in the Apple App Store (Apple Inc...
October 18, 2016: Laryngoscope
Xu Han, Zhihui Cheng, Huanwen Meng
BACKGROUND: Garlic (Allium sativum L.) stalk is a byproduct of garlic production that is normally thought of as waste but is now considered to be a useful biological resource. It is necessary to utilise this resource efficiently and reasonably to reduce environmental pollution and achieve sustainable agricultural development. RESULTS: The effect of decomposed garlic stalk for different durations was investigated in this study using wheat (Triticum aestivum L.) and lettuce (Lactuca sativa var...
October 17, 2016: Journal of the Science of Food and Agriculture
Erina Takai, Yasushi Totoki, Hiromi Nakamura, Mamoru Kato, Tatsuhiro Shibata, Shinichi Yachida
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies. The genomic landscape of the PDAC genome features four frequently mutated genes (KRAS, CDKN2A, TP53, and SMAD4) and dozens of candidate driver genes altered at low frequency, including potential clinical targets. Circulating cell-free DNA (cfDNA) is a promising resource to detect molecular characteristics of tumors, supporting the concept of "liquid biopsy".We determined the mutational status of KRAS in plasma cfDNA using multiplex droplet digital PCR in 259 patients with PDAC, retrospectively...
2016: Advances in Experimental Medicine and Biology
Antonio Oseas de Carvalho Filho, Aristófanes Corrêa Silva, Anselmo Cardoso de Paiva, Rodolfo Acatauassú Nunes, Marcelo Gattass
Using images from the Image Database Consortium and Image Database Resource Initiative (LIDC-IDRI), we developed a methodology for classifying lung nodules. The proposed methodology uses image processing and pattern recognition techniques. To classify volumes of interest into nodules and non-nodules, we used shape measurements only, analyzing their shape using shape diagrams, proportion measurements, and a cylinder-based analysis. In addition, we use the support vector machine classifier. To test the proposed methodology, it was applied to 833 images from the LIDC-IDRI database, and cross-validation with k-fold, where [Formula: see text], was used to validate the results...
October 17, 2016: Medical & Biological Engineering & Computing
Kim Tran, Chaim Bell, Nathan Stall, George Tomlinson, Allison McGeer, Andrew Morris, Michael Gardam, Howard B Abrams
BACKGROUND: Isolation precautions have negative effects on patient safety, psychological well-being, and healthcare worker contact. However, it is not known whether isolation precautions affect certain hospital-related outcomes. OBJECTIVE: To examine the effect of isolation precautions on hospital-related outcomes and cost of care. DESIGN: Retrospective, propensity-score matched cohort study of inpatients admitted to general internal medicine (GIM) services at three academic hospitals in Toronto, Ontario, Canada between January 2010 and December 2012...
October 17, 2016: Journal of General Internal Medicine
Kitsada Wudhikarn, Udomsak Bunworasate, Jakrawadee Julamanee, Arnuparp Lekhakula, Suporn Chuncharunee, Pimjai Niparuck, Supachai Ekwattanakit, Archrob Khuhapinant, Lalita Norasetthada, Weerasak Nawarawong, Nisa Makruasi, Nonglak Kanitsap, Chittima Sirijerachai, Kanchana Chansung, Peerapon Wong, Tontanai Numbenjapon, Kannadit Prayongratana, Tawatchai Suwanban, Somchai Wongkhantee, Pannee Praditsuktavorn, Tanin Intragumtornchai
Secondary central nervous system (CNS) relapse is a serious and fatal complication of diffuse large B cell lymphoma (DLBCL). Data on secondary CNS (SCNS) relapse were mostly obtained from western countries with limited data from developing countries. We analyzed the data of 2034 newly diagnosed DLBCL patients enrolled into the multi-center registry under Thai Lymphoma Study Group from setting. The incidence, September 2006 to December 2013 to represent outcome from a resource limited pattern, management, and outcome of SCNS relapse were described...
October 18, 2016: Annals of Hematology
Jeffrey P Stephens, Aaron B Stoler, Jason P Sckrabulis, Aaron J Fetzer, Keith A Berven, Scott D Tiegs, Thomas R Raffel
According to ecological stoichiometry (ES), the growth of a consumer with abundant resources should increase as body and resource stoichiometry become more similar. However, for organisms with complex life cycles involving distinct changes in biology, nutrient demands might change in response to ontogenetic changes in body stoichiometry. Tadpole growth and development has been found to be largely nitrogen (N) limited, as predicted for organisms developing N-rich tissues like muscle. However, tadpole metamorphosis includes periods of rapid development of phosphorus (P)-rich bones in preparation for a terrestrial lifestyle...
October 17, 2016: Oecologia
M Utsch
Nowadays, issues of religiosity and spirituality are viewed differently than 50 years ago. Social upheaval, migration and secularization have changed the interpretation of religious meaning but have not made religion obsolete. This article describes the differences between a religious and a secular global view and defines spirituality as attachment to a larger entirety. The resources of spirituality are described and the dangers of fanaticism and fundamentalism should not be neglected. Criteria for healthy belief are compared to religious delusion...
October 17, 2016: Der Nervenarzt
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