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https://www.readbyqxmd.com/read/29352189/mechanical-behavior-of-a-soft-hydrogel-reinforced-with-three-dimensional-printed-microfibre-scaffolds
#1
Miguel Castilho, Gernot Hochleitner, Wouter Wilson, Bert van Rietbergen, Paul D Dalton, Jürgen Groll, Jos Malda, Keita Ito
Reinforcing hydrogels with micro-fibre scaffolds obtained by a Melt-Electrospinning Writing (MEW) process has demonstrated great promise for developing tissue engineered (TE) constructs with mechanical properties compatible to native tissues. However, the mechanical performance and reinforcement mechanism of the micro-fibre reinforced hydrogels is not yet fully understood. In this study, FE models, implementing material properties measured experimentally, were used to explore the reinforcement mechanism of fibre-hydrogel composites...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348235/digitization-of-multistep-organic-synthesis-in-reactionware-for-on-demand-pharmaceuticals
#2
Philip J Kitson, Guillaume Marie, Jean-Patrick Francoia, Sergey S Zalesskiy, Ralph C Sigerson, Jennifer S Mathieson, Leroy Cronin
Chemical manufacturing is often done at large facilities that require a sizable capital investment and then produce key compounds for a finite period. We present an approach to the manufacturing of fine chemicals and pharmaceuticals in a self-contained plastic reactionware device. The device was designed and constructed by using a chemical to computer-automated design (ChemCAD) approach that enables the translation of traditional bench-scale synthesis into a platform-independent digital code. This in turn guides production of a three-dimensional printed device that encloses the entire synthetic route internally via simple operations...
January 19, 2018: Science
https://www.readbyqxmd.com/read/29346608/on-demand-intraoperative-3-dimensional-printing-of-custom-cranioplastic-prostheses
#3
Alexander I Evins, John Dutton, Sayem S Imam, Amal O Dadi, Tao Xu, Du Cheng, Philip E Stieg, Antonio Bernardo
BACKGROUND: Currently, implantation of patient-specific cranial prostheses requires reoperation after a period for design and formulation by a third-party manufacturer. Recently, 3-dimensional (3D) printing via fused deposition modeling has demonstrated increased ease of use, rapid production time, and significantly reduced costs, enabling expanded potential for surgical application. Three-dimensional printing may allow neurosurgeons to remove bone, perform a rapid intraoperative scan of the opening, and 3D print custom cranioplastic prostheses during the remainder of the procedure...
January 13, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29342198/three-dimensional-printing-model-improves-morphological-understanding-in-acetabular-fracture-learning-a-multicenter-randomized-controlled-study
#4
Zhenfei Huang, Wenhao Song, Yaoshen Zhang, Qiang Zhang, Dongsheng Zhou, Xi Zhou, Yu He
Conventional education results in unsatisfactory morphological understanding of acetabular fractures due to lack of three-dimensional (3D) details and tactile feedback of real fractures. Virtual reality (VR) and 3D printing (3DP) techniques are widely applied in teaching. The purpose of this study was to identify the effect of physical model (PM), VR and 3DP models in education of morphological understanding of acetabular fractures. 141 students were invited to participate in this study. Participants were equally and randomly assigned to the PM, VR and 3DP learning groups...
2018: PloS One
https://www.readbyqxmd.com/read/29338816/fabrication-of-isoniazid-rifampicin-poly-l-lactic-acid-donut-shaped-implants-via-three-dimensional-printing-technique
#5
Gui Wu, Wei Gang Wu, Jian Bo Zhou, Qi Xin Zheng
Objective To investigate the possibility of manufacturing dual-drug loaded isoniazid/rifampicin/poly L-lactic acid (PLLA) implant with donut-shaped structure via three-dimensional (3D) printing technique and study the drug release characteristic and biocompatibility of the implant in vitro.Methods PLLA was crushed into particles with diameters around 75-100 μm.Isoniazid and rifampicin bulk drugs were dissolved into the organic dissolvent respectively to be the binding liquid.The 3D printing machine fabricated the donut-shaped implant via binding the PLLA powder layer by layer...
December 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29336146/coordination-triggered-hierarchical-folate-zinc-supramolecular-hydrogels-leading-to-printable-biomaterials
#6
Kaerdun Liu, Shihao Zang, Rongrong Xue, Jinghui Yang, Lizhi Wang, Jianbin Huang, Yun Yan
Printable hydrogels desired in bioengineering have extremely high demands on biocompatibility and mechanic strength, which can hardly be achieved in conventional hydrogels made with biopolymers. Here we show that on employment of the strategy of coordination triggered hierarchical self-assembly of naturally occurred small molecule folic acid, supramolecular hydrogels with robust mechanical elastic modulus comparable to synthetic double network (DN) polymer gels can be made at concentrations below 1 %. A sequence of hierarchical steps are involved in the formation of this extraordinary hydrogel: petrin rings on folate form tetramers through hydrogen bonding, tetramers stack into nanofibers by π-π stacking, zinc ions cross-link the nanofibers into larger scale fibrils, and further crosslink the fibril network to gel water...
January 16, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29334259/development-of-three-dimensional-brain-arteriovenous-malformation-model-for-patient-communication-and-young-neurosurgeon-education
#7
Mengqi Dong, Guangzhong Chen, Kun Qin, Xiaowen Ding, Dong Zhou, Chao Peng, Shaojian Zeng, Xianming Deng
PURPOSE: Rapid prototyping technology is used to fabricate three-dimensional (3D) brain arteriovenous malformation (AVM) models and facilitate presurgical patient communication and medical education for young surgeons. METHODS: Two intracranial AVM cases were selected for this study. Using 3D CT angiography or 3D rotational angiography images, the brain AVM models were reconstructed on personal computer and the rapid prototyping process was completed using a 3D printer...
January 15, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29333083/optimal-load-for-bone-tissue-scaffolds-with-an-assigned-geometry
#8
Antonio Boccaccio, Antonio E Uva, Michele Fiorentino, Giuseppe Monno, Andrea Ballini, Apollonia Desiate
Thanks to the recent advances of three-dimensional printing technologies the design and the fabrication of a large variety of scaffold geometries was made possible. The surgeon has the availability of a wide number of scaffold micro-architectures thus needing adequate guidelines for the choice of the best one to be implanted in a patient-specific anatomic region. We propose a mechanobiology-based optimization algorithm capable of determining, for bone tissue scaffolds with an assigned geometry, the optimal value Lopt of the compression load to which they should be subjected, i...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29330656/3d-imaging-3d-printing-and-3d-virtual-planning-in-endodontics
#9
REVIEW
Pratik Shah, B S Chong
The adoption and adaptation of recent advances in digital technology, such as three-dimensional (3D) printed objects and haptic simulators, in dentistry have influenced teaching and/or management of cases involving implant, craniofacial, maxillofacial, orthognathic and periodontal treatments. 3D printed models and guides may help operators plan and tackle complicated non-surgical and surgical endodontic treatment and may aid skill acquisition. Haptic simulators may assist in the development of competency in endodontic procedures through the acquisition of psycho-motor skills...
January 12, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29328672/three-dimensional-printing-hollow-polymer-template-mediated-graphene-lattices-with-tailorable-architectures-and-multifunctional-properties
#10
Qiangqiang Zhang, Feng Zhang, Xiang Xu, Chi Zhou, Dong Lin
It is a significant challenge to concurrently achieve scalable fabrication of graphene aerogels with three-dimensional (3D) tailorable architectures (e.g., lattice structure) and controllable manipulation of microstructures on the multiscale. Herein, we highlight 3D graphene lattices (GLs) with complex engineering architectures that were delicately designed and manufactured via 3D stereolithography printed hollow polymer template-mediated hydrothermal process coupled with freeze-drying strategies. The resulting GLs with overhang beams and columns show a 3D geometric configuration with hollow-carved features at the macroscale, while the construction elements of graphene cellular on the microscale exhibit a well-ordered and honeycomb-like microstructure with high porosity...
January 12, 2018: ACS Nano
https://www.readbyqxmd.com/read/29327553/-preliminary-development-of-drill-template-assisted-placement-of-reverse-intramedullary-lag-screw-for-superior-ramus-of-pubis-using-three-dimentional-print-technique
#11
Yi Zheng, Xin-Hua Yuan, Wei-Bin Wang, Qing-Jiang Pang
OBJECTIVE: To investigate the feasibility of a drill template for the placement of reverse intramedullary lag screws on the outside of the pubis based on digital design and 3D printing technology. METHODS: The preoperative CT images of a 23-year-old male patient with pelvic fracture were collected retrospectively. According to the Young and Burgess classification, the type of pelvic fracture was LC IIwith the 3D printing technology. The data was reconstructed by 3D imaging reconstruction software to produce 1:1 three dimensional model...
January 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29325763/clinical-experience-with-three-dimensional-printing-techniques-in-orthopedic-trauma
#12
Ji Wan Kim, Yongkoo Lee, Joonho Seo, Jai Hyung Park, Yong Min Seo, Sung Soo Kim, Hyun Chul Shon
BACKGROUND: To report our experiences with the use of three-dimensional (3D) printing in the field of orthopedic trauma. METHODS: This retrospective study enrolled 24 patients from three university teaching hospitals in whom 3D printing technique was applied: 14 patients with acetabular fractures and 10 patients with clavicular shaft fractures. We summarized our experiences with 3D printed bone models. RESULTS: Three-dimensional printed acetabular models improved understanding of complex acetabular anatomy and fracture pattern to plan the optimal positioning of a reduction clamp and the trajectory of screws...
January 8, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29320372/a-dentin-derived-hydrogel-bioink-for-3d-bioprinting-of-cell-laden-scaffolds-for-regenerative-dentistry
#13
Avathamsa Athirasala, Anthony Tahayeri, Greeshma Thrivikraman, Cristiane M França, Nelson Monteiro, Victor Tran, Jack Ferracane, Luiz E Bertassoni
Recent studies in tissue engineering have adopted extracellular matrix (ECM) derived scaffolds as natural and cytocompatible microenvironments for tissue regeneration. The dentin matrix, specifically, has been shown to be associated with a host of soluble and insoluble signaling molecules that can promote odontogenesis. Here, we have developed a novel bioink, blending printable alginate (3% w/v) hydrogels with the soluble and insoluble fractions of the dentin matrix. We have optimized the printing parameters and the concentrations of the individual components of the bioink for print accuracy, cell viability and odontogenic potential...
January 10, 2018: Biofabrication
https://www.readbyqxmd.com/read/29318224/a-highly-efficient-waterborne-photoinitiator-for-visible-light-induced-three-dimensional-printing-of-hydrogels
#14
Jieping Wang, Sascha Stanic, Altan Alpay Altun, Martin Schwentenwein, Kurt Dietliker, Lu Jin, Jürgen Stampfl, Stefan Baudis, Robert Liska, Hansjörg Grützmacher
A bis(acyl)phosphane oxide (BAPO) photoinitiator was conveniently synthesized in an efficient one-pot process. It shows excellent dispersibility in water, good storage stability, and high photo-reactivity in 3D printing of hydrogels under visible-light irradiation (460 nm).
January 10, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29317370/3d-printed-gelatin-scaffolds-of-differing-pore-geometry-modulate-hepatocyte-function-and-gene-expression
#15
Phillip L Lewis, Richard M Green, Ramille N Shah
Three dimensional (3D) printing is highly amenable to the fabrication of tissue-engineered organs of a repetitive microstructure such as the liver. The creation of uniform and geometrically repetitive tissue scaffolds can also allow for the control over cellular aggregation and nutrient diffusion. However, the effect of differing geometries, while controlling for pore size, has yet to be investigated in the context of hepatocyte function. In this study, we show the ability to precisely control pore geometry of 3D-printed gelatin scaffolds...
January 6, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29316208/effect-of-bone-sialoprotein-coated-three-dimensional-printed-calcium-phosphate-scaffolds-on-primary-human-osteoblasts
#16
Anja Klein, Andreas Baranowski, Ulrike Ritz, Hermann Götz, Sascha Heinemann, Stefan Mattyasovszky, Pol M Rommens, Alexander Hofmann
The combination of the two techniques of rapid prototyping 3D-plotting and bioactive surface functionalization is presented, with emphasis on the in vitro effect of Bone Sialoprotein (BSP) on primary human osteoblasts (hOBs). Our primary objective was to demonstrate the BSP influence on the expression of distinctive osteoblast markers in hOBs. Secondary objectives included examinations of the scaffolds' surface and the stability of BSP-coating as well as investigations of cell viability and proliferation. 3D-plotted calcium phosphate cement (CPC) scaffolds were coated with BSP via physisorption...
January 9, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29314616/3d-extrusion-bioprinting-of-single-and-double-network-hydrogels-containing-dynamic-covalent-crosslinks
#17
Leo L Wang, Christopher B Highley, Yi-Cheun Yeh, Jonathan H Galarraga, Selen Uman, Jason A Burdick
The fabrication of three-dimensional (3D) scaffolds is indispensable to tissue engineering and 3D printing is emerging as an important approach towards this. Hydrogels are often used as inks in extrusion-based 3D printing, including with encapsulated cells; however, numerous challenging requirements exist, including appropriate viscosity, the ability to stabilize after extrusion, and cytocompatibility. Here, we present a shear-thinning and self-healing hydrogel crosslinked through dynamic covalent chemistry for 3D bioprinting...
January 3, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29312871/patient-specific-three-dimensional-printing-for-pre-surgical-planning-in-hepatocellular-carcinoma-treatment
#18
Elizabeth Perica, Zhonghua Sun
Background: Recently, three-dimensional (3D) printing has shown great interest in medicine, and 3D printed models may be rendered as part of the pre-surgical planning process in order to better understand the complexities of an individual's anatomy. The aim of this study is to investigate the feasibility of utilising 3D printed liver models as clinical tools in pre-operative planning for resectable hepatocellular carcinoma (HCC) lesions. Methods: High-resolution contrast-enhanced computed tomography (CT) images were acquired and utilized to generate a patient-specific 3D printed liver model...
December 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29310677/chest-wall-reconstruction-with-a-customized-titanium-alloy-prosthesis-fabricated-by-3d-printing-and-rapid-prototyping
#19
Xiaopeng Wen, Shan Gao, Jinteng Feng, Shuo Li, Rui Gao, Guangjian Zhang
BACKGROUND: As 3D printing technology emerge, there is increasing demand for a more customizable implant in the repair of chest-wall bony defects. This article aims to present a custom design and fabrication method for repairing bony defects of the chest wall following tumour resection, which utilizes three-dimensional (3D) printing and rapid-prototyping technology. METHODS: A 3D model of the bony defect was generated after acquiring helical CT data. A customized prosthesis was then designed using computer-aided design (CAD) and mirroring technology, and fabricated using titanium-alloy powder...
January 8, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29309974/three-dimensional-printed-skull-base-simulation-for-transnasal-endoscopic-surgical-training
#20
Jia-Ping Zheng, Chu-Zhong Li, Guo-Qiang Chen, Gui-Dong Song, Ya-Zhuo Zhang
OBJECTIVE: Transnasal endoscopic skull base surgery (SBS) presents a great challenge for inexperienced neurosurgeons due to the complicated anatomic structures, 2-dimensional endoscopic view, limited operative field, and required skills. We designed a personalized multi-material and multi-color three-dimensional (3D)-printed SBS simulation to reproduce the complex anatomy of the skull base. The fidelity and feasibility for anatomical education and surgical training were assessed. METHODS: Two-dimensional computer tomography and magnetic resonance images were collected from a 42-year-old healthy male volunteer...
January 5, 2018: World Neurosurgery
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