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subglottic stenosis

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https://www.readbyqxmd.com/read/29210179/cross-sectional-follow-up-of-voice-outcomes-in-children-who-have-a-history-of-airway-reconstruction-surgery
#1
Wendy Cohen, David M Wynne, Susan Lloyd, Richard B Townsley
OBJECTIVES: This study reports vocal function in a cross-section of children with subglottic stenosis. Each child had a history of laryngotracheal reconstruction and/or cricotracheal resection surgery. Vocal function was measured using laryngoscopy, acoustic analysis, perceptual evaluation and impact of voice on quality of life. DESIGN: All patients aged >5 years with history of laryngotracheal reconstruction and/or cricotracheal resection surgery at the Scottish National Complex Airways service were invited to participate...
December 6, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29189283/effects-of-increasing-airway-pressures-on-the-pressure-of-the-endotracheal-tube-cuff-during-pelvic-laparoscopic-surgery
#2
Eric B Rosero, Esra Ozayar, Javier Eslava-Schmalbach, Abu Minhajuddin, Girish P Joshi
BACKGROUND: Tracheal tube cuff pressures exceeding the perfusion pressures of the tracheal mucosa have been associated with complications such as sore throat, tracheal mucosa ulcers, tracheal rupture, and subglottic stenosis. Despite appropriate inflation, many factors can increase the tracheal cuff pressure during mechanical ventilation. This prospective observational cohort study was designed to test the hypothesis that during a clinical model of decreasing respiratory compliance, the pressure within the endotracheal tube cuff will rise in direct relationship to increases in the airway pressures...
November 17, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29185355/the-effect-of-human-adipose-tissue-derived-mesenchymal-stem-cells-in-rat-s-subglottic-stenosis-model
#3
Seyeon Oh, Dong Young Kim, Min Kwan Baek, Kyunghee Byun, Joo Hyun Woo
OBJECTIVE: Subglottic stenosis remains a clinical challenge. The aim of this study was to evaluate the effect of human adipose tissue-derived mesenchymal stem cells (hAMSCs) in rat model of subglottic stenosis. SUBJECTS AND METHODS: Ninety-six 13-week-old male rats were enrolled in this study. They were divided into 3 groups as normal control (NC) group, a subglottic injury and media injection (SM) group, and a subglottic injury and media-stem cell injection (SMSC) group...
November 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29171660/relationship-between-degree-of-obstruction-and-airflow-limitation-in-subglottic-stenosis
#4
Emily L Lin, Jonathan M Bock, Carlton J Zdanski, Julia S Kimbell, Guilherme J M Garcia
OBJECTIVES: Subglottic stenosis (SGS) is one of the most common airway disorders in pediatric patients. Currently, treatment decisions rely primarily on the Cotton-Myer scale, which classifies SGS severity based on percentage reduction in airspace cross-sectional area (CSA). However, the precise relationship between upper airway resistance and subglottic CSA is unknown. We hypothesize that airway resistance can be described by the Bernoulli Obstruction Theory, which predicts that airway resistance is inversely proportional to airspace CSA ( R∝A-1) in cases of severe constriction...
November 24, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29171300/tubeless-total-intravenous-anesthesia-spontaneous-ventilation-for-adult-suspension-microlaryngoscopy
#5
Mi Jin Yoo, Aaron M Joffe, Tanya K Meyer
INTRODUCTION: Maintaining spontaneous ventilation (SV) under total intravenous anesthesia (TIVA) without an endotracheal tube provides uninterrupted and unobstructed surgical access for suspension microlaryngoscopy (SML). This study describes the method and outcome of adults who underwent SML under tubeless TIVA-SV. METHODS: Retrospective review of adults who underwent SML between June 2014 and September 2016 using TIVA-SV without an endotracheal tube. RESULTS: Sixty-six cases in 36 patients were included with mean age of 50...
November 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29161192/patient-preferences-in-subglottic-stenosis-treatment-a-discrete-choice-experiment
#6
Matthew R Naunheim, Margaret L Naunheim, Vinay K Rathi, Ramon A Franco, Mark G Shrime, Phillip C Song
Objectives Subglottic stenosis can be addressed with several different surgical techniques, but patient preferences for these treatment modalities are poorly understood. Economic methods are increasingly being used to understand how patients make decisions. The objective of this pilot study was to assess preferences in subglottic stenosis treatment using patient-centric stated preference techniques. Study Design Discrete choice experiment (DCE). Setting Academic research facility. Subjects and Methods A computer-based DCE was administered in a monitored setting to volunteers from the general population...
November 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29114419/unanticipated-difficult-airway-in-a-neonate-are-we-prepared-for-this-chaos
#7
Priyanka Pradeep Karnik, Nandini Malay Dave, Madhu Garasia
Unanticipated difficult airway in a neonate is a challenging situation with many difficulties because of inherent anatomical variations. To complicate the situation there is a lack of appropriate equipment, expertise and established guidelines on the management of difficult airway in neonates and infants. There are few published reports regarding the use of available devices for emergency front-of-neck access. We report the case of airway management of a neonate with an unanticipated finding of subglottic stenosis...
October 2017: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/29100647/subglottic-stenosis-in-granulomatosis-with-polyangiitis-the-role-of-laryngotracheal-resection
#8
Christina L Costantino, John L Niles, Cameron D Wright, Douglas J Mathisen, Ashok Muniappan
BACKGROUND: Granulomatosis with polyangiitis (GPA) is associated with development of subglottic stenosis in about one-fourth of all patients. Although endoscopic management is the primary treatment method for tracheobronchial stenosis, some patients have refractory disease, and tracheostomy is required. It is unclear if laryngotracheal resection and reconstruction (LTRR) can be safely performed in patients with GPA. METHODS: A retrospective review was performed of 11 patients with GPA undergoing LTRR...
November 1, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29098448/incidence-of-airway-complications-in-patients-using-endotracheal-tubes-with-continuous-aspiration-of-subglottic-secretions
#9
Jordi Vallés, Susana Millán, Emili Díaz, Eva Castanyer, Xavier Gallardo, Ignacio Martín-Loeches, Marta Andreu, Mario Prenafeta, Paula Saludes, Jorge Lema, Montse Batlle, Néstor Bacelar, Antoni Artigas
BACKGROUND: Continuous aspiration of subglottic secretions is effective in preventing ventilator-associated pneumonia, but it involves a risk of mucosal damage. The main objective of our study was to determine the incidence of airway complications related to continuous aspiration of subglottic secretions. METHODS: In consecutive adult patients with continuous aspiration of subglottic secretions, we prospectively recorded clinical airway complications during the period after extubation...
November 2, 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/29075350/cricoid-malformation-and-endolaryngeal-submucosal-drilling-a-possible-technique
#10
A Zamfir-Chiru-Anton, A E Stanciu, D C Gheorghe
Cricoid malformations vary according to their severity and anatomic features. Some of them get a delayed diagnosis in spite of the complex medical care. Objective: To present a case with a laryngeal malformation and our surgery technique. Material, method: A case presentation of a cannulated child, who previously had a heart surgery, with difficult decannulation. RESULTS: The patient was considered to have an acquired subglottic stenosis due to his medical record. A cricoid cartilage malformation was elicited intraoperatively...
July 2017: Journal of Medicine and Life
https://www.readbyqxmd.com/read/29068802/emergency-ventilation-of-infant-subglottic-stenosis-through-small-gauge-lumen-using-the-ventrain-a-case-report
#11
Francisco J Escribá Alepuz, Javier Alonso García, J Vicente Cuchillo Sastriques, Emilio Alcalá, Pilar Argente Navarro
Postintubation subglottic stenosis is one of the most common causes of stridor in newborns and babies after prolonged mechanical ventilation. Management of this pathology is complex and requires highly trained personnel because it is associated with a high rate of airway-related mortality. This article presents the rescue of a difficult airway in a pediatric patient with subglottic stenosis with a new device available on the market, the Ventrain, offering certain advantages over those available until now.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4...
October 24, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/29064319/short-versus-long-term-stenting-in-children-with-subglottic-stenosis-undergoing-laryngotracheal-reconstruction
#12
David F Smith, Alessandro de Alarcon, Niall D Jefferson, Meredith E Tabangin, Michael J Rutter, Robin T Cotton, Catherine K Hart
Objectives Suprastomal stents are routinely used in laryngotracheal reconstruction (LTR) to stabilize grafts and provide framework to sites of repair. However, the duration of stenting varies according to patient history and physician preference. We examined outcomes of short- versus long-term stenting in children with subglottic stenosis (SGS) undergoing LTR. Study Design Case series with chart review. Setting Tertiary care pediatric hospital. Subjects and Methods Thirty-six children <18 years old who underwent double-stage LTR for SGS from January 2012 to January 2015 were included...
October 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29050090/-laryngotracheal-resection-and-reconstruction-for-the-treatment-of-acquired-laryngotracheal-stenosis
#13
L J Ma, Y Xiao, Q W Yang, J Wang
Objective: To analyze the efficacy of laryngotracheal resection and reconstruction for acquired laryngotracheal stenosis, and to discuss the prevention of complication. Methods: The clinical outcomes of seventy patients with acquired laryngotracheal stenosis, treated with laryngotracheal resection and reconstruction were retrospectively reviewed between January 2007 and December 2016. The degree of stenosis was classified according to Myer-Cotton classification as follows: grade Ⅱ(n=7), grade Ⅲ(n=38) and grade Ⅳ(n=27)...
October 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29050089/-a-retrospective-analysis-of-co-2-laser-and-microdebrider-for-the-treatment-of-severe-juvenile-on-set-recurrent-respiratory-papillomatosis
#14
Q W Yang, W Xu, W Guo, W X Cui, Y R Li, X Y Wang, J Yang, X Y Li
Objective: Juvenile on-set recurrent respiratory papillomatosis (JORRP) can be an aggressive and potentially life-threatening disease. To emphasize the importance of complication prevention in local excision surgery, the single-center experience of RRP treatment in a group of patients with relatively short recurrence-free-interval (>4 times/yrs) was reported. Methods: Data of 49 patients underwent papilloma resection during 2002-2013 were retrospectively analyzed. Combined techniques of laser microsurgery and microdebriders were used to remove papillomas, prevent the formation of scar tissue and improve respiratory distress...
October 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29044543/investigating-the-effects-of-laryngotracheal-stenosis-on-upper-airway-aerodynamics
#15
Tracy Cheng, David Carpenter, Seth Cohen, David Witsell, Dennis O Frank-Ito
OBJECTIVE: Very little is known about the impact of laryngotracheal stenosis (LTS) on inspiratory airflow and resistance, especially in air hunger states. This study investigates the effect of LTS on airway resistance and volumetric flow across three different inspiratory pressures. METHODS: Head-and-neck computed tomography scans of 11 subjects from 2010 to 2016 were collected. Three-dimensional reconstructions of the upper airway from the nostrils to carina, including the oral cavity, were created for one subject with a normal airway and for 10 patients with LTS...
October 17, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29038859/refashioned-lamb-tissue-as-an-animal-model-for-training-complex-techniques-of-laryngotracheal-stenosis-surgery
#16
Lluís Nisa, Pedro Teiga, Gustavo Barreto da Cunha, Biswanath Roy, Riza Onder Gunaydin, Kishore Sandu
Open reconstructive upper airway surgery for laryngotracheal stenosis (LTS), whether for subglottic or tracheal stenosis, constitutes a group of complex approaches. LTS requiring open reconstruction is overall rare and primarily performed at tertiary centres. This poses an obvious challenge for the acquisition and maintenance of surgical skills for this group of complex approaches. In this context, animal models provide a unique opportunity for open reconstructive airway surgery training. Such models ought to take into consideration ethical aspects, be easily available and easy to maintain, and have similar macroscopic anatomical features to the human laryngotracheal frame...
December 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28990664/hormone-receptors-analysis-in-idiopathic-progressive-subglottic-stenosis
#17
Ivana Fiz, Zeid Bittar, Cesare Piazza, Jan Constantin Koelmel, Federico Gatto, Diego Ferone, Francesco Fiz, Diana Di Dio, Alexander Bosse, Giorgio Peretti, Christian Sittel
OBJECTIVE: Idiopathic subglottic stenosis predominantly affects fertile and perimenopausal women. Estrogens and/or progesterone have been proposed as mediators of its pathogenesis by stimulating collagen deposition within the upper airway. We evaluated the presence and expression of estrogen-alpha (ER-α), estrogen-beta (ER-β), and progesterone receptors (PR) in idiopathic stenotic patients. STUDY DESIGN: A retrospective analysis on 42 surgical specimens from idiopathic stenosis female patients (mean age, 52...
October 9, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28988454/awake-serial-intralesional-steroid-injections-without-surgery-as-a-novel-targeted-treatment-for-idiopathic-subglottic-stenosis
#18
Ramon A Franco, Inna Husain, Lindsay Reder, Paul Paddle
OBJECTIVES/HYPOTHESIS: The fibrotic/erythematous appearance of the subglottis in idiopathic subglottic stenosis (iSGS) hints that it might respond to repeated intralesional steroid treatment similar to keloids. STUDY DESIGN: Retrospective cohort study. METHODS: Thirteen iSGS subjects (six treated in-office with serial intralesional steroid injections [SILSI] versus seven treated endoscopically in the operating room [OR] followed by awake SILSI) between October 2011 and April 2017...
October 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28940431/targeting-metabolic-abnormalities-to-reverse-fibrosis-in-iatrogenic-laryngotracheal-stenosis
#19
Michael K Murphy, Kevin M Motz, Dacheng Ding, Linda Yin, Madhavi Duvvuri, Michael Feeley, Alexander T Hillel
OBJECTIVE: Management of laryngotracheal stenosis (LTS) remains primarily surgical, with a critical need to identify targets for adjuvant therapy. Laryngotracheal stenosis scar fibroblasts exhibit a profibrotic phenotype with distinct metabolic shifts, including an increased glycolysis/oxidative phosphorylation ratio. This study examines the effects of the glutamine antagonist 6-diazo-5-oxo-l-norleucine (DON) on collagen production, gene expression, proliferation, and metabolism of human LTS-derived fibroblasts in vitro...
September 20, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28929076/role-of-topical-medication-in-prevention-of-post-extubation-subglottic-stenosis
#20
Saravanam Prasanna Kumar, Arunachalam Ravikumar, Johnson Thanka
Iatrogenic laryngotracheal injury is the most serious complication of endotracheal intubation since this method of establishing airway was first described by Eugene Bouchut in 1858. Even today, subglottic stenosis is the most dreaded complication of intubation. This animal study is focused on the host tissue response to intubation induced injury resulting in subglottic stenosis and methods to prevent this complication. To assess the role of topically applied Mitomycin-C and Triamcinolone Acetonide in wound healing process following post-extubation subglottic injury...
September 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
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