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https://www.readbyqxmd.com/read/27805581/studying-wnt-signaling-during-patterning-of-conducting-airways
#1
John Snowball, Manoj Ambalavanan, Debora Sinner
Wnt signaling pathways play critical roles during development of the respiratory tract. Defining precise mechanisms of differentiation and morphogenesis controlled by Wnt signaling is required to understand how tissues are patterned during normal development. This knowledge is also critical to determine the etiology of birth defects such as lung hypoplasia and tracheobronchomalacia. Analysis of earliest stages of development of respiratory tract imposes challenges, as the limited amount of tissue prevents the performance of standard protocols better suited for postnatal studies...
October 16, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27766409/laser-tracheobronchoplasty-a-novel-technique-for-the-treatment-of-symptomatic-tracheobronchomalacia
#2
Paul Castellanos, Manjunath Mk, Ihab Atallah
The management of tracheobronchomalacia is a very challenging problem with few treatment options. This study aims to evaluate the outcomes of a novel surgical treatment for membranous tracheobronchomalacia. A consecutive series of patients with tracheobronchomalacia were treated with two to three holmium laser scarring surgeries of the hyperdynamic tracheal and bronchial walls for the purpose of stiffening them through fibrosis. Patients filled out a Dyspnea Index questionnaire before and after treatment. Ten patients were treated for their tracheobronchomalacia with a mean age of 54 years...
October 20, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27729153/successful-conservative-management-of-a-rare-complication-of-tracheostomy-extensive-posterior-tracheal-false-pouch
#3
Jennifer F Ha, Waseem Ostwani, Glenn Green
INTRODUCTION: With the advent of improved neonatal and pediatric intensive care management, tracheostomy is increasingly performed in children requiring prolonged ventilation. Even though tracheostomy is generally a safe procedure, there remains mortality and morbidity associated with it. OBJECTIVE: We report a rare complication of a tracheostomy tube resulting in extensive erosion and posterior tracheal false pouch secondary to a large tracheostomy tube and high positive end expiratory pressure in a 12-month-old infant...
November 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27641078/a-comparison-of-virtual-bronchoscopy-versus-flexible-bronchoscopy-in-the-diagnosis-of-tracheobronchomalacia-in-children
#4
Siew Choo Su, Ian Brent Masters, Helen Buntain, Kieran Frawley, Anubhav Sarikwal, Debbie Watson, Frances Ware, Jan Wuth, Anne Bernadette Chang
INTRODUCTION: Flexible bronchoscopy (FB) is the current gold standard for diagnosing tracheobronchomalacia. However, it is not always feasible and virtual bronchoscopy (VB), acquired from chest multi-detector CT (MDCT) scan is an alternative diagnostic tool. We determined the sensitivity, specificity, and positive and negative predictive values of VB compared to FB in diagnosing tracheobronchomalacia. METHODS: Children aged <18-years scheduled for FB and MDCT were recruited...
September 18, 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27607887/-tracheobronchoplasty-for-severe-diffuse-tracheomalacia
#5
H Hoffmann, D Gompelmann, C P Heußel, H Dienemann, R Eberhardt
Patients with diffuse airway instability due to tracheobronchomalacia or excessive dynamic airway collapse are typically highly symptomatic, with marked dyspnoea, recurrent bronchopulmonary infections and excruciating intractable cough. Silicone stents achieve immediate symptom control, but are - due to the typical complications associated with stent treatment - usually not an option for long-term treatment. The aim of surgical intervention is definitive stabilisation of the trachea and of both main bronchi by posterior splinting of the Paries membranaceus with a polypropylene mesh...
September 2016: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/27578945/tracheobronchomalacia-in-obstructive-airway-diseases
#6
Ravindran Chetambath
No abstract text is available yet for this article.
July 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27578929/tracheobronchomalacia-excessive-dynamic-airway-collapse-in-patients-with-chronic-obstructive-pulmonary-disease-with-persistent-expiratory-wheeze-a-pilot-study
#7
Girish Sindhwani, Rakhee Sodhi, Manju Saini, Varuna Jethani, Sushant Khanduri, Baltej Singh
BACKGROUND: Tracheobronchomalacia (TBM) refers to a condition in which structural integrity of cartilaginous wall of trachea is lost. Excessive dynamic airway collapse (EDAC) is characterized by excessive invagination of posterior wall of trachea. In both these conditions, airway lumen gets compromised, especially during expiration, which can lead to symptoms such as breathlessness, cough, and wheezing. Both these conditions can be present in obstructive lung diseases; TBM due to chronic airway inflammation and EDAC due to dynamic compressive forces during expiration...
July 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27568138/advances-in-surgical-treatment-of-congenital-airway-disease
#8
William S Ragalie, Michael E Mitchell
Tracheobronchomalacia (TBM) is frequently present in infants and children with congenital heart disease (CHD). Infants with CHD and TBM appear to do worse than those without TBM. The principle of operative intervention for TBM is to improve function of the airway and clinical status. When indicated, conventional surgical options include tracheostomy, aortopexy, tracheoplasty, and anterior tracheal suspension. There is no consensus on the optimal treatment of severe tracheobonchomalacia, which can be associated with a mortality rate as high as 80%...
2016: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27541367/tracheobronchomalacia-diagnosed-by-tracheobronchography-in-ventilator-dependent-infants
#9
Winston M Manimtim, Douglas C Rivard, Ashley K Sherman, Brent E Cully, Brenton D Reading, Charisse I Lachica, Linda L Gratny
BACKGROUND: Tracheobronchomalacia prevalence in premature infants on prolonged mechanical ventilation is high. OBJECTIVE: To examine the prevalence of tracheobronchomalacia diagnosed by tracheobronchography in ventilator-dependent infants, and describe the demographic, clinical and dynamic airway characteristics of those infants with tracheobronchomalacia. MATERIALS AND METHODS: This retrospective review studies 198 tracheobronchograms performed from 1998 to 2011 in a cohort of 158 ventilator-dependent infants <2 years of age...
December 2016: Pediatric Radiology
https://www.readbyqxmd.com/read/27530791/-application-of-electronic-bronchoscopy-in-pediatric-intensive-care-patients-with-difficult-ventilator-weaning
#10
Lu Gong, Lan Hu
OBJECTIVE: To investigate the value of electronic bronchoscopy in the etiological diagnosis and treatment of pediatric intensive care patients with difficult ventilator weaning. METHODS: A retrospective analysis was performed for the clinical data of 92 pediatric intensive care patients with difficult ventilator weaning and underwent electronic bronchoscopy. RESULTS: Among all the 92 children, the most common underlying disease was respiratory system disease (39 children)...
August 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/27511508/is-silicone-stent-insertion-a-clinically-useful-option-for-tracheobronchomalacia
#11
Levent Dalar, Seda Tural Önür, Cengiz Özdemir, Sinem Nedime Sökücü, Ahmet Levent Karasulu, Sedat Altin
BACKGROUND/AIM: Tracheobronchomalacia (TBM) leads to the obstruction of expiratory airflow and interference with secretion clearance. Stabilization of the airway wall using a silicon stent or laser coagulation of the posterior wall may be treatment options. This study aimed to retrospectively analyze which interventional bronchoscopic method could be used to provide airway stabilization and gain control of symptoms and for whom this method could be used. MATERIALS AND METHODS: Fifteen patients who had received treatment in our interventional pulmonology unit were analyzed...
February 17, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/27237407/surgical-treatment-of-tracheobronchomalacia-a-novel-approach
#12
REVIEW
Sigrid Bairdain, David Zurakowski, Christopher W Baird, Russell W Jennings
Tracheobronchomalacia, as a whole, is likely misdiagnosed and underestimated as a cause of respiratory compromise in pediatric patients. Currently, there is no standardized approach for the overall evaluation of pediatric tracheobronchomalacia (TBM) and the concept of excessive dynamic airway collapse (EDAC); no grading score for the evaluation of severity; nor a standardized means to successfully approach TBM and EDAC. This paper describes our experience standardizing the approach to these complex patients whose backgrounds include different disease etiologies, as well as a variety of comorbid conditions...
June 2016: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/27058715/awareness-competencies-and-practice-patterns-in-tracheobronchomalacia-a-survey-of-pulmonologists
#13
Ismael Matus, William Richter, Sriniwasan B Mani
BACKGROUND: Tracheobronchomalacia (TBM) is a disorder of expiratory central airway collapse. TBM is separate from excessive dynamic airway collapse. Historically TBM has lacked a universally accepted definition. No consensus recommendations on evaluation and management exist. We suspect these unresolved issues contribute to deficits in pulmonologists' awareness and management of TBM. METHODS: We created a 20-question survey obtaining information about overall awareness, knowledge base, competencies, and practice patterns in managing TBM...
April 2016: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/27022925/respiratory-conditions-associated-with-tracheobronchomegaly-mounier-kuhn-syndrome-a-study-of-seventeen-cases
#14
Pierre Schmitt, Levent Dalar, Stéphane Jouneau, Bénédicte Toublanc, Juliette Camuset, Gérard Chatte, Laurent Cellerin, Hervé Dutau, Stéphane Sanchez, Maxime Sauvage, Jean-Michel Vergnon, Sandra Dury, Gaetan Deslée, François Lebargy
BACKGROUND: Mounier-Kuhn syndrome (MKS) is a rare disorder characterized by enlargement of the trachea and main bronchi and associated with recurrent respiratory tract infections. OBJECTIVE: This multicenter, retrospective study was carried out to describe respiratory conditions associated with tracheobronchomegaly. METHODS: Nine institutions involved in the 'Groupe d'Endoscopie de Langue Française' (GELF) participated in this study. A standard form was used to record patient characteristics, treatments and follow-up from medical charts...
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/26982389/trial-of-portable-continuous-positive-airway-pressure-for-the-management-of-tracheobronchomalacia
#15
Maxime Patout, Laura Mylott, Ruth Kent, Gill Arbane, Patrick B Murphy, Nicholas Hart
No abstract text is available yet for this article.
May 15, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/26968054/treatment-of-severe-tracheobronchomalacia-ten-year-experience
#16
Lorraine A de Trey, Julia Dudley, Hasnaa Ismail-Koch, Andrew Durward, Hannah Bellsham-Revell, Sean Blaney, Ian Hore, Conal B Austin, Gavin A Morrison
INTRODUCTION: Paediatric tracheobronchomalacia is a rare but potentially serious condition. Severe tracheobronchomalacia requires intervention or operation. This is an evaluation of a ten-year experience at an institution. METHODS: In this retrospective study all patients were included that required an intervention for severe tracheobronchomalacia from 2003 to 2012. Symptoms, aetiology, comorbidities, localisation of the malacia, age at diagnosis, therapeutic measures and associated complications were evaluated...
April 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/26874192/central-airway-obstruction-benign-strictures-tracheobronchomalacia-and-malignancy-related-obstruction
#17
REVIEW
Septimiu Dan Murgu, Katarine Egressy, Balaji Laxmanan, Guillermo Doblare, Rosamaria Ortiz-Comino, D Kyle Hogarth
The purpose of this article is to provide an update on methods for palliating symptoms in patients with histologically benign and malignant central airway obstruction. We review the published literature within the past decade on postintubation, posttracheostomy, and TB- and transplant-related airway strictures; tracheobronchomalacia; and malignant airway obstruction. We review terminology, classification systems, and parameters that impact treatment decisions. The focus is on how airway stent insertion fits into the best algorithm of care...
August 2016: Chest
https://www.readbyqxmd.com/read/26655932/robotically-assisted-bilateral-bronchoplasty-for-tracheobronchomalacia
#18
John F Lazar, David H Posner, Wojciech Palka, Laurence N Spier, Richard S Lazzaro
We describe the technique for the first robotically assisted bilateral bronchoplasty for the treatment of tracheobronchomalacia. Since 1954, this disease process has been treated with a right thoracotomy and posterior splinting of the tracheal membrane with mesh to restore the C-shape of the trachea. Traditional video-assisted thoracoscopic surgery has been of limited benefit in these cases owing to technical challenges. A robotically assisted technique offers the dual benefit of a minimally invasive port-based system while reproducing an open surgical technique...
November 2015: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/26570908/1247-avoiding-admissions-for-respiratory-failure-with-non-invasive-ventilation-in-tracheobronchomalacia
#19
Gwen Thompson, Finbar Foley, Jeremy Clain, Patricio Escalante
No abstract text is available yet for this article.
December 2015: Critical Care Medicine
https://www.readbyqxmd.com/read/26266186/spontaneous-tracheal-rupture-in-a-case-of-interstitial-lung-disease-ild-a-case-report
#20
Saurabh Kumar, Sandeep Goel, Ashu Seith Bhalla
Spontaneous tracheal rupture is one of the rare life threatening conditions. Tracheal lacerations are generally secondary to cervical or chest trauma or occurring as a complication of endotracheal intubation. Only two cases of spontaneous tracheal rupture are reported, in adults, one due to acquired tracheobronchomalacia and other due to long term steroid use. We hereby report a very rare case of spontaneous tracheal rupture in young male patient of interstitial lung disease (ILD) who was on steroids for two months and developed spontaneous subcutaneous emphysema and pneumomediastinum...
June 2015: Journal of Clinical and Diagnostic Research: JCDR
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