Mariia Ivanova, Irina Belaya, Nina Kucháriková, Izaque de Sousa Maciel, Liudmila Saveleva, Arto Alatalo, Ilona Juvonen, Navjot Thind, Clarisse Andrès, Riikka Lampinen, Sweelin Chew, Katja M Kanninen
Integrins are receptors that have been linked to various brain disorders, including Alzheimer's disease (AD), the most prevalent neurodegenerative disorder. While Integrin beta-3 (ITGB3) is known to participate in multiple cellular processes such as adhesion, migration, and signaling, its specific role in AD remains poorly understood, particularly in astrocytes, the main glial cell type in the brain. In this study, we investigated alterations in ITGB3 gene and protein expression during aging in different brain regions of the 5xFAD mouse model of AD and assessed the interplay between ITGB3 and astrocytes...
January 12, 2024: Neurobiology of Disease