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https://www.readbyqxmd.com/read/28655271/one-year-results-of-a-randomized-controlled-trial-on-radial-extracorporeal-shock-wave-treatment-with-predictors-of-pain-disability-and-return-to-work-in-patients-with-subacromial-pain-syndrome
#1
Elisabeth Kvalvaag, Cecilie Røe, Kaia B Engebretsen, Helene L Soberg, Niels G Juel, Erik Bautz-Holter, Leiv Sandvik, Jens I Brox
BACKGROUND: Radial extracorporeal Shock Wave Therapy (rESWT) is increasingly used to treat patients with subacromial pain syndrome despite conflicting evidence of its effectiveness. Better knowledge regarding prognostic factors may contribute to the improvement in treatment and prognosis for the patients. AIM: The first aim of this study was to evaluate the effect of rESWT in addition to supervised exercises in patients with subacromial pain syndrome after one year...
June 27, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28655210/diagnosis-and-management-of-myocardial-involvement-in-systemic-immune-mediated-diseases-a-position-statement-of-the-european-society-of-cardiology-working-group-on-myocardial-and-pericardial-disease
#2
Alida L P Caforio, Yehuda Adler, Carlo Agostini, Yannick Allanore, Aris Anastasakis, Michael Arad, Michael Böhm, Philippe Charron, Perry M Elliott, Urs Eriksson, Stephan B Felix, Pablo Garcia-Pavia, Eric Hachulla, Stephane Heymans, Massimo Imazio, Karin Klingel, Renzo Marcolongo, Marco Matucci Cerinic, Antonis Pantazis, Sven Plein, Valeria Poli, Angelos Rigopoulos, Petar Seferovic, Yehuda Shoenfeld, Josè L Zamorano, Ales Linhart
No abstract text is available yet for this article.
June 26, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28655204/trak2-a-novel-regulator-of-abca1-expression-cholesterol-efflux-and-hdl-biogenesis
#3
Nicole J Lake, Rachael L Taylor, Hugh Trahair, K N Harikrishnan, Joanne E Curran, Marcio Almeida, Hemant Kulkarni, Nigora Mukhamedova, Anh Hoang, Hann Low, Andrew J Murphy, Matthew P Johnson, Thomas D Dyer, Michael C Mahaney, Harald H H Göring, Eric K Moses, Dmitri Sviridov, John Blangero, Jeremy B M Jowett, Kiymet Bozaoglu
Aims: The recent failures of HDL-raising therapies have underscored our incomplete understanding of HDL biology. Therefore there is an urgent need to comprehensively investigate HDL metabolism to enable the development of effective HDL-centric therapies. To identify novel regulators of HDL metabolism, we performed a joint analysis of human genetic, transcriptomic, and plasma HDL-cholesterol (HDL-C) concentration data and identified a novel association between trafficking protein, kinesin binding 2 (TRAK2) and HDL-C concentration...
June 26, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28655203/kronos-a-workflow-assembler-for-genome-analytics-and-informatics
#4
M Jafar Taghiyar, Jamie Rosner, Diljot Grewal, Bruno M Grande, Radhouane Aniba, Jasleen Grewal, Paul C Boutros, Ryan D Morin, Ali Bashashati, Sohrab P Shah
Background: The field of next generation sequencing informatics has matured to a point where algorithmic advances in sequence alignment and individual feature detection methods have stabilized. Practical and robust implementation of complex analytical workflows (where such tools are structured into 'best practices' for automated analysis of NGS datasets) still requires significant programming investment and expertise. Results: We present Kronos , a software platform for facilitating the development and execution of modular, auditable and distributable bioinformatics workflows...
June 26, 2017: GigaScience
https://www.readbyqxmd.com/read/28655201/unplanned-reoperation-after-craniotomy-for-tumor-a-national-surgical-quality-improvement-program-analysis
#5
Hormuzdiyar H Dasenbrock, Sandra C Yan, Vamsi Chavakula, William B Gormley, Timothy R Smith, Elizabeth B Claus, Ian F Dunn
BACKGROUND: Reoperation has been increasingly utilized as a metric evaluating quality of care. OBJECTIVE: To evaluate the rate of, reasons for, and predictors of unplanned reoperation after craniotomy for tumor in a nationally accrued population. METHODS: Patients who underwent cranial tumor resection were extracted from the prospective National Surgical Quality Improvement Program registry (2012-2014). Multivariate logistic regression examined predictors of unplanned cranial reoperation...
June 26, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28655192/right-ventricular-dysfunction-after-surgical-left-ventricular-restoration-prevalence-risk-factors-and-clinical-implications
#6
Lotte E Couperus, Victoria Delgado, Marieke E van Vessem, Laurens F Tops, Meindert Palmen, Jerry Braun, Harriëtte F Verwey, Robert J M Klautz, Martin J Schalij, Saskia L M A Beeres
OBJECTIVES: Surgical left ventricular (LV) restoration (SVR) induces changes in LV systolic and diastolic function that may affect postoperative right ventricular (RV) function. This study aimed to evaluate the long-term effect of SVR on RV function, with specific focus on determinants and prognostic implications of RV dysfunction. METHODS: Eighty-six patients (age 60 ± 10 years, 73% male) with clinical and echocardiographic follow-up 2 years after SVR were included...
June 23, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28655190/right-ventricular-function-during-exercise-in-children-after-heart-transplantation
#7
B Cifra, C T Morgan, A Dragulescu, V C Guerra, C Slorach, M K Friedberg, C Manlhiot, B W McCrindle, A I Dipchand, L Mertens
Aims: Right ventricular (RV) dysfunction is a common problem after heart transplant (HTx). In this study, we used semi-supine bicycle ergometry (SSBE) stress echocardiography to evaluate RV systolic and diastolic reserve in paediatric HTx recipients. Methods and results: Thirty-nine pediatric HTx recipients and 23 controls underwent stepwise SSBE stress echocardiography. Colour tissue doppler imaging (TDI) peak systolic (s') and peak diastolic (e') velocities, myocardial acceleration during isovolumic contraction (IVA), and RV free wall longitudinal strain were measured at incremental heart rates (HR)...
June 23, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28655186/catheter-related-right-internal-jugular-vein-thrombosis-after-chest-surgery
#8
P-T Chen, K-C Chang, K-L Hu, C-K Ting, K-H Chan, W-K Chang
Background: Central venous catheters (CVCs) are frequently used for monitoring haemodynamic status and rapidly delivering fluid therapy during the peri- and postoperative periods. Indwelling CVCs are typically used 7-14 days postoperatively for additional monitoring and treatment, but patients may develop asymptomatic catheter-related thrombosis, leading to life-threatening pulmonary embolism and death. Early detection helps to avoid such complications. Methods: This prospective observational study investigated the risk factors associated with catheter-related right internal jugular vein thrombosis in patients undergoing chest surgery...
June 26, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28655183/three-year-follow-up-comparing-cognitive-behavioral-therapy-for-depression-to-cognitive-behavioral-therapy-for-insomnia-for-patients-with-both-diagnoses
#9
Kerstin Blom, Susanna Jernelöv, Christian Rück, Nils Lindefors, Viktor Kaldo
This three-year follow-up compared insomnia treatment to depression treatment for patients with both diagnoses. Forty-three participants were randomized to either treatment, in the form of Internet-delivered therapist-guided cognitive behavior therapy, and 37 (86%) provided primary outcome data at the three-year follow-up. After three years, reductions on depression severity were similar in both groups (between-group effect-size, d = 0.33, p = .45), while the insomnia treatment had superior effects on insomnia severity (d = 0...
June 24, 2017: Sleep
https://www.readbyqxmd.com/read/28655174/diagnosis-and-management-of-osteopetrosis-consensus-guidelines-from-the-osteopetrosis-working-group
#10
Calvin C Wu, Michael J Econs, Linda A DiMeglio, Karl L Insogna, Michael A Levine, Paul J Orchard, Weston P Miller, Anna Petryk, Eric T Rush, Dolores M Shoback, Leanne M Ward, Lynda E Polgreen
Background: Osteopetrosis encompasses a group of rare metabolic bone diseases characterized by impaired osteoclast activity or development, resulting in high bone mineral density. Existing guidelines focus on treatment of the severe infantile forms with hematopoietic cell transplantation (HCT), but do not address the management of patients with less severe forms for whom HCT is not the standard of care. Therefore, our objective was to develop expert consensus guidelines that would address the management of these patients...
June 26, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28655171/regulatory-control-and-impulsivity-relate-to-resting-frontal-activity
#11
Lauren B Neal, Philip A Gable
Gray's Reinforcement Sensitivity Theory (RST) asserts three core personality systems: the behavioral approach system (BAS), the fight-flight-freeze system (FFFS), and the revised behavioral inhibition system (r-BIS). Past models of frontal activity link greater relative left frontal activity with Carver and White's (1994) BAS scale and trait impulsivity and greater relative right frontal activity with Carver and White's (1994) BIS scale. However, the original BIS scale assesses both FFFS and r-BIS. Past work linking the BIS scale and right frontal activity does not indicate which system is related to right frontal activity...
June 26, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28655169/hospital-at-home-integrated-care-programme-for-the-management-of-disabling-health-crises-in-older-patients-comparison-with-bed-based-intermediate-care
#12
Miquel À Mas, Marco Inzitari, Sergi Sabaté, Sebastià J Santaeugènia, Ramón Miralles
Objective: to analyse the clinical impact of a home-based Intermediate Care model in the Catalan health system, comparing it with usual bed-based care. Design: quasi-experimental longitudinal study. Setting: hospital Municipal de Badalona and El Carme Intermediate Care Hospital, Badalona, Catalonia, Spain. Participants: we included older patients with medical and orthopaedic disabling health crises in need of Comprehensive Geriatric Assessment (CGA) and rehabilitation...
June 24, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28655168/bmp4-uses-several-different-effector-pathways-to-regulate-proliferation-and-differentiation-in-the-epithelial-and-mesenchymal-tissue-compartments-of-the-developing-mouse-ureter
#13
Tamrat M Mamo, Anna B Wittern, Marc-Jens Kleppa, Tobias Bohnenpoll, Anna-Carina Weiss, Andreas Kispert
Heterozygous loss of Bmp4 results both in humans and mice in severe malformation of the urinary tract. These defects have at least partially been attributed to loss of expression of Bmp4 in the ureteric mesenchyme, yet the cellular and molecular function of this signal as well as its effector pathways in this tissue have remained incompletely resolved. Here, we show that mice with a conditional deletion of Bmp4 in the ureteric mesenchyme exhibited hydroureter and hydronephrosis at newborn stages due to functional and physical ureter obstruction...
June 26, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28655164/role-of-diastolic-function-indices-in-the-risk-stratification-of-patients-with-mixed-aortic-valve-disease
#14
Alexander C Egbe, Arooj R Khan, Amber Boler, Sameh M Said, Jeffrey B Geske, William R Miranda, Emmanuel Akintoye, Heidi M Connolly, Carole A Warnes, Jae K Oh
Aims: Determine the role of diastolic function indices in pre-operative and post-operative risk stratification in patients with moderate mixed aortic valve disease (MAVD). Methods and results: A retrospective study was conducted of asymptomatic patients with moderate MAVD (a combination of moderate aortic stenosis and moderate aortic regurgitation) and an ejection fraction of 50% or more who were followed up at Mayo Clinic from 1 January 2004, to 31 December 2013...
June 23, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28655157/neuroinflammation-and-tau-interact-with-amyloid-in-predicting-sleep-problems-in-aging-independently-of-atrophy
#15
Anders Martin Fjell, Ane-Victoria Idland, Roser Sala-Llonch, Leiv Otto Watne, Tom Borza, Anne Brækhus, Tarjei Lona, Henrik Zetterberg, Kaj Blennow, Torgeir Bruun Wyller, Kristine Beate Walhovd
Sleep problems relate to brain changes in aging and disease, but the mechanisms are unknown. Studies suggest a relationship between β-amyloid (Aβ) accumulation and sleep, which is likely augmented by interactions with multiple variables. Here, we tested how different cerebrospinal fluid (CSF) biomarkers for brain pathophysiology, brain atrophy, memory function, and depressive symptoms predicted self-reported sleep patterns in 91 cognitively healthy older adults over a 3-year period. The results showed that CSF levels of total- and phosphorylated (P) tau, and YKL-40-a marker of neuroinflammation/astroglial activation-predicted poor sleep in Aβ positive older adults...
June 26, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28655156/comparison-of-latest-generation-transfemoral-self-expandable-and-balloon-expandable-transcatheter-heart-valves
#16
Andreas Schaefer, Matthias Linder, Moritz Seiffert, Gerhard Schoen, Florian Deuschl, Niklas Schofer, Yvonne Schneeberger, Stefan Blankenberg, Hermann Reichenspurner, Ulrich Schaefer, Lenard Conradi
OBJECTIVES: We herein aimed to compare acute 30-day outcomes of latest-generation self-expandable and balloon-expandable transcatheter heart valves. METHODS: From 2012 through 2016, 104 consecutive patients (study group, 69.2% female, 81.7 ± 5.5 years, logEuroSCORE I 15.9 ± 9.3%) received transfemoral transcatheter aortic valve implantation using the Symetis ACURATE neo ® transcatheter heart valve. A control group of patients after transfemoral transcatheter aortic valve implantation with the Edwards Sapien 3™ transcatheter heart valve was retrieved from our database and matched to the study group...
June 26, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28655154/risk-model-for-deaths-and-renal-replacement-therapy-dependence-in-patients-with-acute-kidney-injury-after-cardiac-surgery
#17
Shiren Sun, Feng Ma, Qiaoneng Li, Ming Bai, Yangping Li, Yan Yu, Chen Huang, Hanmin Wang, Xiaoxuan Ning
OBJECTIVES: Acute kidney injury (AKI) is a serious complication after cardiac surgery and is associated with increased in-hospital deaths. Renal replacement therapy (RRT) is becoming a routine strategy for severe AKI. Our goal was to evaluate the risk factors for death and RRT dependence in patients with AKI after cardiac surgery. METHODS: We included 190 eligible adult patients who had AKI following cardiac surgery and who required RRT at our centre from November 2010 to March 2015...
June 23, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28655151/cardioversion-of-atrial-fibrillation-in-a-real-world-setting-non-vitamin-k-antagonist-oral-anticoagulants-ensure-a-fast-and-safe-strategy-compared-to-warfarin
#18
Anne Sofie Frederiksen, Andi Eie Albertsen, Amanda Marie Somer Christesen, Nicklas Vinter, Lars Frost, Dorthe Svenstrup Møller
Aims: Non-vitamin K antagonist oral anticoagulants (NOACs) are increasingly used as thromboembolic prophylaxis in cardioversion. We examined the waiting time to cardioversion and the outcomes in patients with non-valvular atrial fibrillation (AF) of > 48 h of duration who were treated with either NOACs or warfarin. Methods and results: Anticoagulation was handled in a structured, multidisciplinary AF-clinic. The objectives were the waiting time to cardioversion, and thromboembolism and major bleeding events within 60 days...
June 26, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28655150/is-the-frozen-elephant-trunk-procedure-superior-to-the-conventional-elephant-trunk-procedure-for-completion-of-the-second-stage
#19
Saad Rustum, Erik Beckmann, Mathias Wilhelmi, Heike Krueger, Tim Kaufeld, Julia Umminger, Axel Haverich, Andreas Martens, Malakh Shrestha
OBJECTIVES: Our goal was to compare the results and outcomes of second-stage completion in patients who had previously undergone the elephant trunk (ET) or the frozen elephant trunk (FET) procedure for the treatment of complex aortic arch and descending aortic disease. METHODS: Between August 2001 and December 2014, 53 patients [mean age 61 ± 13 years, 64% ( n  = 34) male] underwent a second-stage completion procedure. Of these patients, 32% ( n  = 17) had a previous ET procedure and 68% ( n  = 36) a previous FET procedure as a first-stage procedure...
June 23, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28655148/genetic-variants-in-the-manganese-superoxide-dismutase-2-gene-and-in-the-catalase-gene-are-not-associated-with-alcoholic-chronic-pancreatitis
#20
Alexander Schneider, Jonas Rosendahl, Peter Bugert, Christel Weiss, Heike Unterschütz, Marja-Leena Kylanpää-Bäck, Marko Lempinen, Esko Kemppainen, Brindusa L Diaconu, Matthias P Ebert, Roland H Pfützer
Aims: Oxidative stress may contribute to the development of chronic pancreatitis (CP). The enzymes manganese superoxide dismutase 2 (MnSOD, SOD2) and catalase (CAT) counteract free radical activity within the mitochondria and the cytosol. Moreover, CAT activity contributes to the transformation of ethanol to acetaldehyde, a toxic intermediate product of ethanol metabolism, which has been associated with pancreatic damage. Common functional polymorphisms have been described in the MnSOD gene [rs4880, NM_000636...
June 26, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
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