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Stefan Schreiber, Daniel C Baumgart, Joost P H Drenth, Rafał S Filip, Lucy B Clayton, Kerry Hylands, Alessandro Repici, Cesare Hassan
BACKGROUND:  Polyethylene glycol (PEG) bowel preparations are widely used for precolonoscopy bowel cleansing. This phase 3 trial assessed the efficacy, safety, and tolerability of the novel 1 L PEG-based NER1006 vs. sodium picosulfate plus magnesium citrate (SP + MC) in day-before dosing. METHODS:  Patients requiring colonoscopy were randomized (1 : 1) to receive NER1006 or SP + MC. Cleansing was assessed on the Harefield Cleansing Scale (HCS) and Boston Bowel Preparation Scale (BBPS) using central readers...
July 19, 2018: Endoscopy
Raf Bisschops, Jonathan Manning, Lucy B Clayton, Richard Ng Kwet Shing, Marco Álvarez-González
BACKGROUND:  Polyethylene glycol (PEG)-based bowel preparations are effective cleansers but many require high-volume intake. This phase 3, randomized, blinded, multicenter, parallel-group, central reader-assessed study assessed the 1 L PEG NER1006 bowel preparation vs. standard 2 L PEG with ascorbate (2LPEG). METHODS:  Patients undergoing colonoscopy were randomized (1:1:1) to receive NER1006, as an evening/morning (N2D) or morning-only (N1D) regimen, or evening/morning 2LPEG...
July 19, 2018: Endoscopy
Juan Jin, Kang Hu, Meiyu Ye, Diandian Wu, Qiang He
BACKGROUND/AIMS: The purpose of this study was to investigate the impact of rapamycin (RAP) on autophagy in podocytes and the therapeutic effects of RAP on idiopathic membranous nephropathy (IMN). METHODS: We established an in vitro model of IMN by preconditioning mouse podocytes with puromycin aminonucleoside (PAN). A Cell Counting Kit-8 was used to detect the proliferation of each group of podocytes. Podocyte apoptosis was analyzed by flow cytometry via annexin V/propidium iodide dual staining...
July 19, 2018: Cellular Physiology and Biochemistry
Willemien S Kalteren, Hendrik J Ter Horst, Anne E den Heijer, Leanne de Vetten, Elisabeth M W Kooi, Arend F Bos
BACKGROUND: Perinatal anemia may cause perinatal asphyxia. Its pathophysiology and neurodevelopmental effects are theoretically different from other causes of perinatal asphyxia. OBJECTIVE: The study aimed to determine whether perinatal anemia results in different short-term and long-term outcomes than other causes of perinatal asphyxia treated with therapeutic hypothermia. METHODS: We retrospectively included infants with moderate to severe hypoxic-ischemic encephalopathy, born between May 2009 and October 2015...
July 19, 2018: Neonatology
Sebastião Freitas de Medeiros, Matheus Antônio Souto de Medeiros, Cinthia Marenza Ormond, Jacklyne Silva Barbosa, Márcia Marly Winck Yamamoto
BACKGROUND/AIMS: Definitive polycystic ovary syndrome (PCOS) diagnosis should exclude thyroid dysfunctions. The purpose of the study is to examine the impact of subclinical hypothyroidism on the characteristics of PCOS patients. METHODS: A meta-analysis of the published observational studies was conducted. Medline, Scopus, and Cochrane database search was performed to identify the studies that compared euthyroid PCOS and subclinical hypothyroidism (SCH)-PCOS patients...
2018: Gynecologic and Obstetric Investigation
Jerena Manoharan, Volker Fendrich, Pietro Di Fazio, Carmen Bollmann, Silvia Roth, Barbara Joos, Ioannis Mintziras, Max Albers, Annette Ramaswamy, Philippe Bertolino, Chang X Zhang, Emily P Slater, Detlef K Bartsch, Caroline Lopez-Lopez
<br>Pancreatic neuroendocrine neoplasias (pNEN) are the most common cause of death in adult patients with multiple endocrine neoplasia type 1 (MEN1). So far, only few chemopreventive strategies (e.g. with somatostatin analogues) have been evaluated for MEN1 associated pNENs. In this experimental study on 75 Men1(+ /T) knockout mice, the effect of aspirin (n=25) and an inhibitor of angiotensin-I converting enzyme (enalapril, n=25) compared to controls (n=25) were evaluated as single chemopreventive strategies for pNENs after 6,9,12,15 and 18 months...
July 19, 2018: Neuroendocrinology
Tarek Gharib, Ahmed Mohey, Abdallah Fathi, Mohamed Alhefnawy, Hisham Alazaby, Amr Eldakhakhny
OBJECTIVE: To compare the efficacy and safety of silodosin against tamsulosin as medical expulsion therapeutic agent in stone lower 1/3rd ureter. PATIENTS AND METHODS: One hundred fifty patients divided equally into 2 groups I and II received silodosin 8 mg and tamsulosin 0.4 mg respectively. Patients aged 18 years or older having single unilateral stone 10 mm or less were included in the study. Patients with bilateral or multiple stones, marked hydronephrosis, previous open or endoscopic surgery and having urinary infection were excluded...
July 19, 2018: Urologia Internationalis
Zhong-Ling Qiu, Wei-Jun Wei, Zhen-Kui Sun, Chen-Tian Shen, Hong-Jun Song, Xin-Yun Zhang, Guo-Qiang Zhang, Xiao-Yue Chen, Quan-Yong Luo
BACKGROUND/AIMS: As biomarkers, circulating tumor cells (CTCs) from solid tumors can predict metastases and prognoses, and help monitor treatment efficacy. However, conventional CellSearch methods have low sensitivity to differentiated thyroid cancer (DTC) CTCs. In this study, for the first time, we used negative enriching (NE) immunofluorescence-in situ hybridization (iFISH) of chromosome 8 to capture and identify CTCs in DTC patients; and investigated how CTCs correlate with clinicopathological factors and prognosis in DTC patients with distant metastases (DM)...
July 19, 2018: Cellular Physiology and Biochemistry
Fei Zhang, Wu-Xun Peng, Lei Wang, Jian Zhang, Wen-Tao Dong, Jian-Hua Wu, Huai Zhang, Jian-Bo Wang, Yin Zhao
BACKGROUND/AIMS: Avascular necrosis of the femoral head (ANFH) is the focus and difficulty of orthopedic diseases. Recently, tissue engineering bone for this disease has shown a good therapeutic effect. The aim of the present study was to investigate the therapeutic effect of basic fibroblast growth factor (FGF-2) as cytokines transfected bone marrow mesenchymal stem cells (BMSCs) in constructing tissue-engineered bone for avascular necrosis of the femoral head. METHODS: The FGF-2 gene overexpressed lentivirus-transfected rBMSCs with xenogeneic antigen-extracted cancellous bone (XACB) to construct tissue engineered bone, and the model of early avascular necrosis of the femoral head was established by lipopolysaccharide (LPS) combined with hormone...
July 19, 2018: Cellular Physiology and Biochemistry
Xiaohui Ji, Xiaoyun Yang, Nan Wang, Meiyun Kang, Yaping Wang, Liucheng Rong, Yongjun Fang, Yao Xue
BACKGROUND/AIMS: Y+LAT1 protein, encoded by the SLC7A7 gene (a member of the SLC7 family), forms the cationic amino acid transport system y+L (system y+L). This system transports cationic amino acids such as arginine and lysine out of the cell. Arginine, in particular, is critical for T-cell activation and function in the immune response. METHODS: We analyzed the role of the SLC7A7 gene in the cellular activities of Jurkat cells, specifically the cell cycle and cell proliferation, apoptosis, migration, and invasion...
July 19, 2018: Cellular Physiology and Biochemistry
Paolo Spagnolo, Michael Kreuter, Toby M Maher, Wim Wuyts, Francesco Bonella, Tamera J Corte, Stefan Kopf, Derek Weycker, Klaus-Uwe Kirchgaessler, Christopher J Ryerson
BACKGROUND: Diabetes mellitus is a possible risk factor for the development of idiopathic pulmonary fibrosis (IPF), yet the effect of antidiabetic therapy on the course of IPF is unknown. OBJECTIVES: This post hoc analysis assessed the effect of metformin on clinically relevant outcomes in patients with IPF. METHODS: For the primary analysis, patients randomized to placebo (n = 624) in 3 phase 3, double-blind, controlled trials of pirfenidone (CAPACITY [NCT00287716 and NCT00287729]; ASCEND [NCT01366209]) were categorized by baseline metformin use...
July 19, 2018: Respiration; International Review of Thoracic Diseases
Omri Nativ, Zaher Bahouth, Edmond Sabo, Sarel Halachmi, Boaz Moskovitz, Elias G Hellou, Zaid Abassi, Ofer Nativ
INTRODUCTION: The aim of our study was to examine the influence of tumor complexity and operative variables on the degree and rate of post-nephron sparing surgery (NSS) acute kidney injury (AKI). METHODS: We retrospectively reviewed the records of 477 patients who underwent NSS for enhancing renal masses in our institution. AKI was determined using the latest definition by AKIN and RIFLE criteria. Serum creatinine was assessed daily starting from day 1 post-surgery and until discharge (usually on postoperative day 3)...
July 19, 2018: Urologia Internationalis
Leonardo G Goll, Roberto F Artoni, Maria C Gross, Lucas R A Mello, Maria P B Coelho, Mara C Almeida, Carlos H Schneider
The chromosomes of 2 flea beetle species from central Amazonia, Omophoita abbreviata and O. aequinoctialis (Alticini), were investigated through analysis of meiotic and mitotic cells. These species belong to the subtribe Oedionychina, a taxon that has unique cytogenetic features, such as giant sex chromosomes which are aligned at a distance during meiosis I (asynaptic). O. abbreviata and O. aequinoctialis have a meiotic formula of 10II + X + y, which is predominant in this subtribe. While the species of the genus Omophoita possess a relatively stable karyotype, a typical feature for Oedionychina, the present study identified inter- and intrapopulational variation in chromosome morphology, constitutive heterochromatin, and the presence and number of B chromosomes in O...
July 20, 2018: Cytogenetic and Genome Research
Amanda Schenatto Ferreira, Danilo de Oliveira Silva, Liliam Barbuglio Del Priore, Carmen Lucia Gomes Garcia, Matheus Henrique Maiolini Ducatti, Ana Flavia Balotari Botta, Marina Cabral Waiteman, Fábio Mícolis de Azevedo
OBJECTIVES: To investigate pain level and function limitation in adolescent athletes and physically active non-athletes with PFP. DESIGN: Cross-sectional study. SETTING: Adolescent athletes were recruited at a sport center complex. Adolescent non-athletes were recruited from upper secondary schools. PARTICIPANTS: 108 adolescents diagnosed with PFP: 42 adolescent athletes and 66 adolescent non-athletes. MAIN OUTCOME MEASURES: To evaluate the level of pain, a visual analog scale (VAS) was used and to evaluate the overall function, the Knee Outcome in Osteoarthritis Survey (KOOS) was used...
July 11, 2018: Physical Therapy in Sport
Renate Von Linsingen, Geórgia Fernanda Gelmini, Maria da Graça Bicalho, Newton Sérgio De Carvalho
The aim of this case- control study was to investigate the association between preterm birth (PTB), MICA-129 A/G dimorphism and sMICA levels. Fifty pregnant women with singleton pregnancy and previous PTB, or clinic diagnostic of threatened preterm labor in the actual pregnancy, or cervical length less than 25 mm and 50 healthy pregnant women were enrolled. DNA was extracted for genotyping for MICA-129 A/G by real-time PCR and sMICA plasma level was quantified by sandwich ELISA assay. Clinical and socioeconomic characteristics, results of TaqMan® genotyping and ELISA quantification were compared between the groups using qui-square, Fisher´s exact or Mann-Whitney test...
July 10, 2018: Journal of Reproductive Immunology
Anamika Das, Jabez W Osborne
Lead (Pb) is reported to have negative effects on the biogeochemical behaviour of the plant growth. In recent years, the significance of rhizoremediation of heavy metals has been of great focus aiding in the development rates of plants under stressed conditions. The present study evaluated the physio-biochemical response of Pennisetum purpureum to different concentrations of Pb (II) viz., 0, 50, 100 and 150 mg kg-1 in the form of lead (II) nitrate. The pre-characterized PGPR strain, Enterobacter cloacae - KU598849 was used to augment the plants...
July 11, 2018: Chemosphere
M Delannoy, S Yehya, D Techer, A Razafitianamaharavo, A Richard, G Caria, M Baroudi, E Montargès-Pelletier, G Rychen, C Feidt
Chlordecone (Kepone or CLD) is a highly persistent pesticide formerly used in French West Indies. Nowadays high levels of this pesticide are still found in soils which represent a subsequent source of contamination for outdoor-reared animals. In that context, sequestering matrices like biochars or activated carbons (ACs) are believed to efficiently decrease the bioavailability of such compounds when added to contaminated soils. The present study intends to test the respective efficiency of soil amendment strategies using commercial ACs or biochars (obtained by a 500 °C or 700 °C pyrolysis of 4 distinct type of wood)...
May 30, 2018: Chemosphere
Amanda Lucena Fernandes, Jefferson Patrício Nascimento, Adelina Pinheiro Santos, Clascídia Aparecida Furtado, Luis Alberto Romano, Carlos Eduardo da Rosa, José Maria Monserrat, Juliane Ventura-Lima
Graphene has been shown to induce toxicity in mammals and marine crustaceans; however, information regarding oxidative stress in fish is scarce. The aim of this study was to evaluate the mechanism of graphene toxicity in different tissues of Danio rerio, considering different parameters of stress. Animals were injected intraperitoneally (i.p.) with 10 μL of suspensions containing different graphene concentrations (5 and 50 mg/L); the gills, intestine, muscle and brain were analysed 48 h later. There was no significant difference in the expression of the gclc (glutamate cysteine ligase catalytic subunit) and nrf2 (nuclear factor (erythroid-derived 2)-like 2) genes after exposure...
July 6, 2018: Chemosphere
Piotr Kocełak, Aleksander Owczarek, Maria Bożentowicz-Wikarek, Aniceta Brzozowska, Małgorzata Mossakowska, Tomasz Grodzicki, Andrzej Więcek, Jerzy Chudek, Magdalena Olszanecka-Glinianowicz
PURPOSE: The aim of the study was to assess plasma RBP4 concentration in elderly subjects in relation to nutritional status and kidney function in the population of the PolSenior Study. MATERIAL AND METHODS: We assessed RBP4, glucose, insulin, albumin, lipid profile, C-reactive protein, (hsCRP) and creatinine concentrations in 2614 PolSenior Study participants (1235 women and 1379 men). The study group was divided based on BMI and HOMA-IR values, and the occurrence of diabetes...
July 16, 2018: Advances in Medical Sciences
Tássia Flávia Dias Castro, José Gilmar da Silva Souza, Aline Ferreira Souza de Carvalho, Isadora de Lima Assis, Marcel José Palmieri, Larissa Fonseca Andrade Vieira, Silvana Marcussi, Monica Rodrigues Ferreira Machado, Luis David Solis Murgas
The effects of different concentrations of commercial product based on tebuconazole, on adults of Danio rerio, were evaluated through novel tank diving test and micronucleus and comet assay tests. A total of 320 adult D. rerio were divided into eight tanks and exposed to concentrations of 0; 100; 200 and 300 μg/L the commercial product based on tebuconazole, with their respective replicates at 24, 72 and 96 h. The results showed a behavioral deviation of zebrafish and a significant (p < 0.05) increase in DNA damage as a function of exposed time and different concentrations of the commercial product in relation to the negative control...
June 30, 2018: Environmental Toxicology and Pharmacology
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