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cartilage tissue engineering

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https://www.readbyqxmd.com/read/29670834/hybrid-scaffolds-of-hyaluronic-acid-and-collagen-loaded-with-prednisolone-an-interesting-system-for-osteoarthritis
#1
Farhad Mohammadi, Soliman Mohammadi Samani, Nader Tanideh, Fatemeh Ahmadi
Purpose: Cartilage regeneration by using polymeric scaffolds is a new option for treatment of osteoarthritis. A good scaffold for tissue engineering should copy the characteristics of natural extracellular matrix. The purpose of this study was to make a dosage form with proper reliability and stability for cartilage repair. Methods: Hybrid scaffolds containing different ratios of hyaluronic acid (HA) and collagen were prepared and loaded with prednisolone as anti-inflammatory agent. Two different dosage forms (lyophilized implantable disk and thermo-sensitive gels) were examined...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29668079/co-culture-of-adipose-derived-stem-cells-and-chondrocytes-on-three-dimensionally-printed-bioscaffolds-for-craniofacial-cartilage-engineering
#2
Robert J Morrison, Hassan B Nasser, Khaled N Kashlan, David A Zopf, Derek J Milner, Colleen L Flanangan, Matthew B Wheeler, Glenn E Green, Scott J Hollister
OBJECTIVES/HYPOTHESIS: Reconstruction of craniofacial cartilagenous defects are among the most challenging surgical procedures in facial plastic surgery. Bioengineered craniofacial cartilage holds immense potential to surpass current reconstructive options, but limitations to clinical translation exist. We endeavored to determine the viability of utilizing adipose-derived stem cell-chondrocyte co-culture and three-dimensional (3D) printing to produce 3D bioscaffolds for cartilage tissue engineering...
April 18, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29666653/mesenchymal-stem-cells-in-oriented-plga-acecm-composite-scaffolds-enhance-structure-specific-regeneration-of-hyaline-cartilage-in-a-rabbit-model
#3
Weimin Guo, Xifu Zheng, Weiguo Zhang, Mingxue Chen, Zhenyong Wang, Chunxiang Hao, Jingxiang Huang, Zhiguo Yuan, Yu Zhang, Mingjie Wang, Jiang Peng, Aiyuan Wang, Yu Wang, Xiang Sui, Wenjing Xu, Shuyun Liu, Shibi Lu, Quanyi Guo
Articular cartilage lacks a blood supply and nerves. Hence, articular cartilage regeneration remains a major challenge in orthopedics. Decellularized extracellular matrix- (ECM-) based strategies have recently received particular attention. The structure of native cartilage exhibits complex zonal heterogeneity. Specifically, the development of a tissue-engineered scaffold mimicking the aligned structure of native cartilage would be of great utility in terms of cartilage regeneration. Previously, we fabricated oriented PLGA/ACECM (natural, nanofibrous, articular cartilage ECM) composite scaffolds...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29663898/electrospun-fibers-for-cartilage-tissue-regeneration
#4
Guo Li, Sirong Shi, Shiyu Lin, Tengfei Zhou, Xiaoru Shao, Qiao Huang, Bofeng Zhu, Xiaoxiao Cai
BACKGROUND: Due to its poor self-repair ability, the cartilage injury has been a great challenge in clinical work. OBJECTIVE: The conventional therapies for cartilage injury mostly form fibrocartilage with weaker strength and flexibility compared to natural cartilage. The development of tissue engineering technology provides a new approach for cartilage repair and regeneration. RESULTS: An appropriate scaffold is one of key factors in cartilage tissue engineering...
April 17, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29660790/development-of-a-tissue-engineered-artificial-ligament-reconstruction-of-injured-rabbit-medial-collateral-ligament-with-elastin-collagen-and-ligament-cell-composite-artificial-ligament
#5
Masaki Hirukawa, Shingo Katayama, Tatsuya Sato, Kota Inoue, Kosuke Niwa, Naoya Ito, Tetsuya Hattori, Takashi Hosoi, Hironori Unno, Yoshiaki Suzuki, Masahiro Hasegawa, Keiichi Miyamoto, Takashi Horiuchi
Ligament reconstruction using a tissue-engineered artificial ligament (TEAL) requires regeneration of the ligament-bone junction such that fixation devices such as screws and end buttons do not have to be used. The objective of this study was to develop a TEAL consisting of elastin-coated polydioxanone (PDS) sutures covered with elastin and collagen fibers preseeded with ligament cells. In a pilot study, a ring-type PDS suture with a 2.5 mm (width) bone insertion was constructed with/without elastin coating (Ela-coat and Non-coat) and implanted into two bone tunnels, diameter 2...
April 16, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29659132/3d-extrusion-printing-induces-polymer-molecule-alignment-and-cell-organization-within-engineered-cartilage
#6
Ting Guo, Julia P Ringel, Casey G Lim, Laura G Bracaglia, Maeesha Noshin, Hannah B Baker, Douglas A Powell, John P Fisher
Proper cell-material interactions are critical to remain cell function and thus successful tissue regeneration. Many fabrication processes have been developed to create microenvironments to control cell attachment and organization on a 3D scaffold. However, these approaches often involve heavy engineering and only the surface layer can be patterned. We found that 3D extrusion based printing at high temperature and pressure will result an aligned effect on the polymer molecules, and this molecular arrangement will further induce the cell alignment and different differentiation capacities...
April 16, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29658148/biochemical-and-biomechanical-characterization-of-equine-cervical-facet-joint-cartilage
#7
S A O'Leary, J L White, J C Hu, K A Athanasiou
BACKGROUND: The equine cervical facet joint is a site of significant pathology. Located bilaterally on the dorsal spine, these diarthrodial joints work in conjunction with the intervertebral disc to facilitate appropriate spinal motion. Despite the high prevalence of pathology in this joint, the facet joint is understudied and thus lacking in viable treatment options. OBJECTIVE: The goal of this study was to characterise equine facet joint cartilage and provide a comprehensive database describing the morphological, histological, biochemical, and biomechanical properties of this tissue...
April 15, 2018: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29642550/healing-of-osteochondral-defects-implanted-with-biomimetic-scaffolds-of-poly-%C3%AE%C2%B5-caprolactone-hydroxyapatite-and-glycidyl-methacrylate-modified-hyaluronic-acid-in-a-minipig
#8
Yi-Ho Hsieh, Bo-Yuan Shen, Yao-Horng Wang, Bojain Lin, Hung-Maan Lee, Ming-Fa Hsieh
Articular cartilage is a structure lack of vascular distribution. Once the cartilage is injured or diseased, it is unable to regenerate by itself. Surgical treatments do not effectively heal defects in articular cartilage. Tissue engineering is the most potential solution to this problem. In this study, methoxy poly(ethylene glycol)-block-poly(ε-caprolactone) (mPEG-PCL) and hydroxyapatite at a weight ratio of 2:1 were mixed via fused deposition modeling (FDM) layer by layer to form a solid scaffold. The scaffolds were further infiltrated with glycidyl methacrylate hyaluronic acid loading with 10 ng/mL of Transforming Growth Factor-β1 and photo cross-linked on top of the scaffolds...
April 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29626700/combinatory-approach-for-developing-silk-fibroin-scaffolds-for-cartilage-regeneration
#9
Viviana P Ribeiro, Alain da Silva Morais, F Raquel Maia, Raphael F Canadas, João B Costa, Ana L Oliveira, Joaquim M Oliveira, Rui L Reis
Several processing technologies and engineering strategies have been combined to create scaffolds with superior performance for efficient tissue regeneration. Cartilage tissue is a good example of that, presenting limited self-healing capacity together with a high elasticity and load-bearing properties. In this work, novel porous silk fibroin (SF) scaffolds derived from horseradish peroxidase (HRP)-mediated crosslinking of highly concentrated aqueous SF solution (16 wt.%) in combination with salt-leaching and freeze-drying methodologies were developed for articular cartilage tissue engineering (TE) applications...
April 4, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29623134/generating-chondromimetic-mesenchymal-stem-cell-spheroids-by-regulating-media-composition-and-surface-coating
#10
BanuPriya Sridharan, Amy D Laflin, Michael S Detamore
INTRODUCTION: Spheroids of mesenchymal stem cells (MSCs) in cartilage tissue engineering have been shown to enhance regenerative potential owing to their 3D structure. In this study, we explored the possibility of priming spheroids under different media to replace the use of inductive surface coatings for chondrogenic differentiation. METHODS: Rat bone marrow-derived MSCs were organized into cell spheroids by the hanging drop technique and subsequently cultured on hyaluronic acid (HA) coated or non-coated well plates under different cell media conditions...
April 2018: Cellular and Molecular Bioengineering
https://www.readbyqxmd.com/read/29621359/applying-chlorogenic-acid-in-an-alginate-scaffold-of-chondrocytes-can-improve-the-repair-of-damaged-articular-cartilage
#11
Xin Cheng, Ke Li, Shengsong Xu, Peizhi Li, Yu Yan, Guang Wang, Zachary Berman, Rui Guo, Jianxin Liang, Sira Traore, Xuesong Yang
Damaged cartilage has very low regenerative potential which has led to the search for novel tissue-engineering approaches to help treat cartilage defects. While various approaches have been reported, there is no perfect treatment currently. In this study we evaluated the effects of a plant extract, chlorogenic acid (CGA), as part of chondrocyte transplantation on a model of knee joint injury in chicks. First, primary cultured chondrocytes used to evaluate the effects of CGA on chondrogenesis. Then using an articular cartilage injury model of chick knee we assessed the functional recovery after transplantation of the complexes containing chondrocytes and CGA in an alginate scaffold...
2018: PloS One
https://www.readbyqxmd.com/read/29618900/evaluation-of-in-vitro-chondrocytic-differentiation-a-stem-cell-research-initiative-at-the-king-abdulaziz-university-kingdom-of-saudi-arabia
#12
Aisha Al-Yamani, Gauthaman Kalamegam, Farid Ahmed, Mohammed Abbas, Khalid Hussein Wali Sait, Nisreen Anfinan, Mohammad Khalid Al-Wasiyah, Etimad A Huwait, Mamdouh Gari, Mohammed Al-Qahtani
Mesenchymal stem cells (MSCs) from various sources have been used in cartilage differentiation with variable success. Therefore, it is of interest to evaluate the in vitro differentiation potential of the hWJSCs derived from the human umbilical cords into chondrocytes at the stem cell research facility at the King Abdulaziz University. hWJSCs are an attractive choice for tissue engineering and regenerative medical applications including cartilage regeneration. We evaluated the hWJSCs using classical histological and cartilage related gene expression studies...
2018: Bioinformation
https://www.readbyqxmd.com/read/29608232/cytokine-induced-interleukin-1-receptor-antagonist-protein-expression-in-genetically-engineered-equine-mesenchymal-stem-cells-for-osteoarthritis-treatment
#13
Simone Gabner, Reinhard Ertl, Karsten Velde, Matthias Renner, Florien Jenner, Monika Egerbacher, Juraj Hlavaty
BACKGROUND: A combination of tissue engineering methods employing MSCs together with gene transfer takes the advantage of both innovative strategies and highlights a new approach to target osteoarthritis (OA) and other cartilage defects. Furthermore, the development of systems allowing tunable transgene expression, regulated by natural disease-induced substances is highly desirable. METHODS: Bone marrow-derived equine MSCs were transduced with a lentiviral vector expressing interleukin-1 receptor antagonist (IL-1Ra) gene under control of an inducible NFkB-responsive promoter and the IL-1Ra production upon pro-inflammatory cytokine stimulation (TNFα, IL-1β) was analysed...
April 2, 2018: Journal of Gene Medicine
https://www.readbyqxmd.com/read/29607095/auricular-reconstruction-from-rib-to-3d-printing
#14
REVIEW
Chelsea L Reighard, Scott J Hollister, David A Zopf
The human ear imparts critical form and function and remains one of the most challenging facial features to reconstruct. Over the past century, surgeons have developed numerous techniques and materials for total auricular reconstruction. Refined costal cartilage techniques have remained the gold standard for the past half-century. Recent advancements with novel materials, tissue engineering and 3D printing provide immense potential; however, prohibitive costs and regulatory steps remain as barriers to clinical translation...
January 2018: Journal of 3D printing in medicine
https://www.readbyqxmd.com/read/29602957/nanotechnology-the-scope-and-potential-applications-in-orthopedic-surgery
#15
EDITORIAL
Ashok Gavaskar, D Rojas, F Videla
Nanotechnology involves manipulation of matter measuring 1-100 nm in at least one of its dimensions at the molecular level. Engineering and manipulation of matter at the molecular level has several advantages in the field of medicine (nanomedicine) since most of the biological molecules exist and function at a nanoscale. Though promising, questions still remain on how much of this will ultimately translate into achieving better patient care. Concerns of cost-effectiveness and nanotechnology safety still remain unclear...
March 30, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29600684/-current-advances-on-surgical-treatment-for-knee-articular-cartilage-injuries
#16
REVIEW
Long Xin, Chun Zhang, Wei-Xing Xu, Fu-Hua Zhong, Shun-Wu Fan, Zhen-Bin Wang
Chondral injuries are short of self-healing ability and need to surgical repair after articular cartilage injury. Conventional treatment includes debridement and drainage under arthroscope, micro-fracture, osteochondral autograft transplantation (OATS), mosaiplasty and osteochondral allografts (OCA), autologous chondrocyte implantation (ACI). Debridement and drainage could remove pain factor, and has advantages of simple operation, wide clinical application and early clinical effect. Micro-fracture and osteochondral autograft transplantation is suitable for small area of cartilage repair, while the further effect showed that fibrous cartilage permeated by drill could decrease postoperative clinical effect...
March 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29596037/tissue-engineering-under-microgravity-conditions-use-of-stem-cells-and-specialized-cells
#17
Daniela Grimm, Marcel Egli, Marcus Krüger, Stefan Riwaldt, Thomas J Corydon, Sascha Kopp, Markus Wehland, Petra Wise, Manfred Infanger, Vivek Mann, Alamelu Sundaresan
Experimental cell research studying three-dimensional (3D) tissues in space and on Earth using new techniques to simulate microgravity is currently a hot topic in Gravitational Biology and Biomedicine. This review will focus on the current knowledge of the use of stem cells and specialized cells for tissue engineering under simulated microgravity conditions. We will report on recent advancements in the ability to construct 3D aggregates from various cell types using devices originally created to prepare for spaceflights such as the random positioning machine (RPM), the clinostat, or the NASA-developed rotating wall vessel (RWV) bioreactor, to engineer various tissues such as preliminary vessels, eye tissue, bone, cartilage, multicellular cancer spheroids, and others from different cells...
March 29, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/29594990/-preparation-and-characterization-of-oriented-scaffolds-derived-from-cartilage-extracellular-matrix-and-silk-fibroin
#18
Teng Binhong, Zhao Yanhong, Wang Lianyong, Yang Qiang, Li Hongfa, Li Yunjie
OBJECTIVE: This study aims to prepare oriented scaffolds derived from a cartilage extracellular matrix (CECM) and silk fibroin (SF) and use to investigate their physicochemical property in cartilage tissue engineering. METHODS: Oriented SF-CECM scaffolds were prepared from 6% mixed slurry (CECM:SF=1:1) through modified temperature gradient-guided thermal-induced phase separation, followed by freeze drying. The SF-CECM scaffolds were evaluated by scanning electron microscopy (SEM) and histological staining analyses and determination of porosity, water absorption, and compressive elastic modulus of the materials...
February 1, 2018: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29580978/sheep-as-a-model-for-evaluating-mesenchymal-stem-stromal-cell-msc-based-chondral-defect-repair
#19
REVIEW
Ena Music, Kathryn Futrega, Michael R Doran
Osteoarthritis results from the degradation of articular cartilage and is one of the leading global causes of pain and immobility. Cartilage has a limited capacity for self-repair. While repair can be enhanced through surgical intervention, current methods often generate inferior fibrocartilage and repair is transient. The development of tissue engineering strategies to improve repair outcomes is an active area of research. While small animal models such as rodents and rabbits are often used in early pre-clinical work, larger animals that better recapitulate the anatomy and loading of the human joint are required for late-stage preclinical evaluation...
March 23, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29580181/decellularised-cartilage-directs-chondrogenic-differentiation-creation-of-a-fracture-callus-mimetic
#20
Wollis Jude Vas, Mittal Shah, Thomas Stephen Blacker, Michael Roland Duchen, Paul Sibbons, Scott John Roberts
Complications that arise from impaired fracture healing have considerable socioeconomic implications. Current research in the field of bone tissue engineering predominantly aims to mimic the mature bone tissue microenvironment. This approach, however, may produce implants that are intrinsically unresponsive to the cues present during the initiation of fracture repair. As such, this study describes the development of decellularised xenogeneic hyaline cartilage matrix in an attempt to mimic the initial reparative phase of fracture repair...
March 27, 2018: Tissue Engineering. Part A
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