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https://www.readbyqxmd.com/read/28434967/cysteinylated-transthyretin-as-a-discriminator-of-cardiovascular-risk-in-patients-with-diabetes-mellitus
#1
Ichiro Wakabayashi, Mikio Marumo, Daisuke Nonaka, Lyang-Ja Lee, Jun Mukai, Makoto Ohki, Kenji Tanaka, Kagehiro Uchida
BACKGROUND: The cysteine residue on transthyretin (TTR) is susceptible to be oxidized, and serum cysteinylated TTR (Cys-TTR) level is thought to reflect oxidative stress. The purpose of this study was to elucidate the relationship between Cys-TTR and arterial stiffness, a known predictor of cardiovascular disease, in patients with type 2 diabetes. METHODS: The subjects were 105 male outpatients with type 2 diabetes. Arterial stiffness was evaluated by measuring cardio-ankle vascular index (CAVI)...
April 20, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28434370/transthyretin-attr-amyloidosis-nephropathy-lessons-from-a-ttr-stabilizer-molecule
#2
Ana Rocha, Ana Silva, Márcio Cardoso, Idalina Beirão, Cristina Alves, Paulo Teles, Teresa Coelho, Luísa Lobato
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28434346/refine-penetrance-estimates-in-the-main-pathogenic-variants-of-transthyretin-hereditary-familial-amyloid-polyneuropathy-ttr-fap-using-a-new-non-parametric-approach-npse
#3
Farida Gorram, Flora Alarcon, Hervé Perdry, Bérénice Hébrard, Thibaud Damy, Pascale Fanen, Benoît Funalot, Gregory Nuel, Violaine Planté-Bordeneuve
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28434337/treatment-of-transthyretin-cardiomyopathy-with-a-ttr-specific-antisense-oligonucleotide-ionis-ttrrx
#4
Merrill D Benson, Elizabeth J Ackermann, Brett P Monia
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28434328/transthyretin-related-hereditary-amyloidosis-in-an-argentinian-family-with-ttr-tyr114cys-mutation
#5
María Adela Aguirre, Elsa Mercedes Nucifora, Marcelo Rugiero, Patricia Sorroche, María Soledad Saez, Diego Hernán Giunta, María Lourdes Posadas-Martinez, Bruno Rafael Boietti
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28434297/efficiency-of-sirna-for-removal-of-transthyretin-v30m-in-a-ttr-leptomeningeal-animal-model
#6
Paula Gonçalves, Helena Martins, Susete Costelha, Maria J Saraiva
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28434291/the-importance-of-pre-clinical-studies-in-animal-models-of-ttr-amyloidosis-for-the-discovery-of-novel-patient-disease-biomarkers
#7
N P Gonçalves, D Martins, M J Saraiva
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28434259/establishing-and-validating-the-fluorescent-amyloid-ligand-h-ftaa-heptamer-formyl-thiophene-acetic-acid-to-identify-transthyretin-amyloid-deposits-in-carpal-tunnel-syndrome
#8
Katharina Hahn, K Peter R Nilsson, Per Hammarström, Peter Urban, Rolf Rüdiger Meliss, Hans-Michael Behrens, Sandra Krüger, Christoph Röcken
Transthyretin-derived (ATTR) amyloidosis is a frequent finding in carpal tunnel syndrome. We tested the following hypotheses: the novel fluorescent amyloid ligand heptameric formic thiophene acetic acid (h-FTAA) has a superior sensitivity for the detection of amyloid compared with Congo red-staining; Amyloid load correlates with patient gender and/or patient age. We retrieved 208 resection specimens obtained from 184 patients with ATTR amyloid in the carpal tunnel. Serial sections were stained with Congo red, h-FTAA and an antibody directed against transthyretin (TTR)...
April 23, 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28434003/cytotoxic-effects-of-transthyretin-aggregates-in-an-epidermoid-cell-line
#9
Vai Hong Fong, Amandio Vieira
OBJECTIVE: Skin amyloid deposits can occur as part of systemic amyloidoses including those involving misfolded- aggregated transthyretins (agTTR). Pathological effects of agTTR on the skin are not well understood. The main objective of the current study was to examine the toxicity of agTTR upon a human keratinocyte cell line. METHODS: Cells were analyzed for indicators of oxidative stress after treatment with normal soluble TTR or the same pre-aggregation concentration of agTTR...
April 22, 2017: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28430919/non-coding-rnas-in-cardiovascular-diseases-diagnostic-and-therapeutic-perspectives
#10
Wolfgang Poller, Stefanie Dimmeler, Stephane Heymans, Tanja Zeller, Jan Haas, Mahir Karakas, David-Manuel Leistner, Philipp Jakob, Shinichi Nakagawa, Stefan Blankenberg, Stefan Engelhardt, Thomas Thum, Christian Weber, Benjamin Meder, Roger Hajjar, Ulf Landmesser
Recent research has demonstrated that the non-coding genome plays a key role in genetic programming and gene regulation during development as well as in health and cardiovascular disease. About 99% of the human genome do not encode proteins, but are transcriptionally active representing a broad spectrum of non-coding RNAs (ncRNAs) with important regulatory and structural functions. Non-coding RNAs have been identified as critical novel regulators of cardiovascular risk factors and cell functions and are thus important candidates to improve diagnostics and prognosis assessment...
April 18, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28429248/time-in-therapeutic-range-as-a-marker-for-thrombotic-and-bleeding-outcomes-in-fontan-patients
#11
Jenna M Faircloth, Kristin M Miner, Tarek Alsaied, Nicole Nelson, Julie Ciambarella, Tomoyuki Mizuno, Joseph S Palumbo, Alexander A Vinks, Gruschen R Veldtman
Fontan patients managed with warfarin are at risk not only for thrombotic events, but also for bleeding episodes as a consequence of anticoagulation treatment. The aim of this study was to determine whether time spent in patient specified therapeutic range (TTR), when managed in a cardiology-based pharmacist managed anticoagulation clinic (PMAC), is a useful target metric for monitoring, as well as improving outcomes. A single center retrospective review was conducted evaluating TTR of all Fontan patients (n = 45) on warfarin managed in our outpatient cardiology pharmacist managed anticoagulation clinic (PMAC) during a 19 month time frame...
April 20, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28425041/familial-amyloid-cardiomyopathy-masquerading-as-chronic-guillain-barre-syndrome-things-are-not-always-what-they-seem
#12
Die Hu, Ling Liu, Shuguang Yuan, Yuhong Yi, Daoquan Peng
Familial amyloid cardiomyopathy is a challenging condition that mimics many other diseases, particularly in patients with pronounced neurological presentations and unexplained or equivocal cardiac abnormalities. In this case, a 57-year-old man was admitted for outpatient cardiological evaluation of progressive right heart failure and limb paraesthesias. The patient presented with hypertension, chronic Guillain-Barre syndrome, and sick sinus syndrome. Transthoracic echocardiograms showed a thickened ventricular wall and enlarged atrium...
April 19, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28422428/identification-of-novel-transthyretin-fibril-formation-inhibitors-using-structure-based-virtual-screening
#13
Gabriella Ortore, Adriano Martinelli
Transthyretin (TTR) is the primary carrier for thyroxine (T4) in cerebrospinal fluid and a secondary carrier in blood. TTR is a stable homotetramer, but certain factors, genetic or environmental, could promote its degradation to form amyloid fibrils. A docking study in the wild-type TTR crystal structures was planned; our aim was to design new ligands able to inhibit TTR fibril formation. The computational protocol was thought to overcome the multiple binding modes of the ligands induced by the specularity of the TTR binding site and by the pseudosymmetry of the site pockets, which generally weaken such structure-based studies...
April 19, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28413892/amyloid-detection-in-the-transverse-carpal-ligament-of-patients-with-hereditary-attr-v30m-amyloidosis-and-carpal-tunnel-syndrome
#14
Raquel Samões, Ricardo Taipa, Kátia Valdrez, Isabel Gonçalves, Manuel Melo Pires, Ana Martins da Silva, Teresa Coelho
INTRODUCTION: Carpal tunnel syndrome (CTS) is a nonspecific manifestation of hereditary ATTR amyloidosis (ATTRm). Amyloid deposition of wild-type TTR (WT-ATTR) has been found in transverse carpal ligament (TCL) in idiopathic CTS. We retrospectively studied a group of patients with ATTRm and CTS submitted to carpal tunnel release surgery (CTRS). METHODS: From the nerve conduction studies performed in our Clinical Unit dedicated to hereditary amyloidosis between July 2009 and October 2013, we selected patients who fulfilled neurophysiological criteria for CTS, had been submitted to CTRS and whose TCL was available for pathology...
April 16, 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28412566/removal-mechanisms-of-benzotriazoles-in-duckweed-lemna-minor-wastewater-treatment-systems
#15
Georgia Gatidou, Maria Oursouzidou, Aimilia Stefanatou, Athanasios S Stasinakis
The fate of five benzotriazoles (1H-benzotriazole, BTR; 4-methyl-1H-benzotriazole, 4TTR; 5-methyl-1H-benzotriazole, 5TTR; xylytriazole, XTR and 5-chlorobenzotriazole, CBTR) was studied in batch and continuous-flow Lemna minor systems and the role of different mechanisms on their removal was evaluated. Single and joint toxicity experiments were initially conducted using the Organization for Economic Co-operation and Development (OECD) protocol 221 and no inhibition on specific growth rate of Lemna minor was observed for concentrations up to 200μgL(-1)...
April 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28412319/genetic-and-non-genetic-factors-affecting-the-quality-of-anticoagulation-control-and-vascular-events-in-atrial-fibrillation
#16
Yun Kyung Park, Mi Ji Lee, Jae Ha Kim, Jin Soo Lee, Rae Woong Park, Gyeong-Moon Kim, Chin-Sang Chung, Kwang Ho Lee, June Soo Kim, Soo-Youn Lee, Oh Young Bang
BACKGROUND: Warfarin has a narrow therapeutic window. We hypothesized that genetic factors related to warfarin metabolism (CYP2C9) and activity (VKORC1) would show stronger associations than modifiable factors with the quality of anticoagulation control and risks for thromboembolism and hemorrhage. METHODS: In this retrospective cohort analysis, clinical and genetic data were collected from 380 patients with atrial fibrillation (AF) who were followed for an average observation period of 4 years...
April 12, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28412068/vitreous-amyloidosis-ocular-systemic-and-genetic-insights
#17
Pradeep Venkatesh, Harathy Selvan, Sundararajan Baskar Singh, Divya Gupta, Seema Kashyap, Shreyas Temkar, Varun Gogia, Koushik Tripathy, Rohan Chawla, Rajpal Vohra
PURPOSE: To report the unique clinical and surgical characteristics encountered in eyes with vitreous amyloidosis. Systemic evaluation and visual outcome after vitrectomy are discussed. A novel mutation in the transthyretin gene (TTR) in Indian patients with familial amyloid polyneuropathy (FAP) is described. DESIGN: Retrospective, observational study. PARTICIPANTS: Ten eyes of 5 patients from 2 pedigrees with a diagnosis of vitreous amyloidosis...
April 12, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28408116/-prevalence-of-oral-anticoagulation-and-quality-of-its-management-in-primary-healthcare-a-study-by-the-health-sentinel-network-of-the-region-of-valencia-spain
#18
Ana Boned-Ombuena, Jordi Pérez-Panadés, Aurora López-Maside, Maite Miralles-Espí, Sandra Guardiola Vilarroig, Desamparados Adam Ruiz, Oscar Zurriaga
OBJECTIVE: To estimate the prevalence of patients with oral anticoagulant therapy (OAT) in the Region of Valencia and to evaluate the quality of management of OAT with vitaminK antagonists (VKA) carried out in primary healthcare. DESIGN: Observational cross-sectional study conducted through the Health Sentinel Network of the Region of Valencia, which includes a survey and the retrospective analysis of OAT monitoring. SETTING: Primary healthcare, Region of Valencia, Spain...
April 10, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28407005/c1q-ablation-exacerbates-amyloid-deposition-a-study-in-a-transgenic-mouse-model-of-attrv30m-amyloid-neuropathy
#19
Elena Panayiotou, Eleni Fella, Revekka Papacharalambous, Stavros Malas, Maria Joao Saraiva, Theodoros Kyriakides
ATTRV30M amyloid neuropathy is a lethal autosomal dominant sensorimotor and autonomic neuropathy, caused by deposition of amyloid fibrils composed of aberrant transthyretin (TTR). Ages of onset and penetrance exhibit great variability and genetic factors have been implicated. Complement activation co-localizes with amyloid deposits in amyloidotic neuropathy and is possibly involved in the kinetics of amyloidogenesis. A candidate gene approach has recently identified C1q polymorphisms to correlate with disease onset in a Cypriot cohort of patients with ATTRV30M amyloid neuropathy...
2017: PloS One
https://www.readbyqxmd.com/read/28400700/serum-retinol-binding-protein-induced-endothelial-inflammation-is-mediated-through-the-activation-of-toll-like-receptor-4
#20
Mei Du, Ashley Martin, Franklin Hays, Jennifer Johnson, Rafal A Farjo, Krysten M Farjo
PURPOSE: Elevation of serum retinol-binding protein 4 (RBP4) induces inflammation in primary human retinal microvascular endothelial cells (HRECs) via a retinol-independent mechanism; thus, it may play a causative role in the development and progression of vascular lesions in diabetic retinopathy (DR). Since HRECs do not express the classical RBP4 receptor, stimulated by retinoic acid gene 6 (STRA6), this study focuses on identifying the endothelial cell receptor and signaling that mediate RBP4-induced inflammation...
2017: Molecular Vision
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