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https://www.readbyqxmd.com/read/29338073/impact-of-time-to-testosterone-rebound-and-comorbidity-on-the-risk-of-cause-specific-mortality-in-men-with-unfavorable-risk-prostate-cancer
#1
Susan G R McDuff, Ming-Hui Chen, Andrew A Renshaw, Marian J Loffredo, Philip W Kantoff, Anthony V D'Amico
BACKGROUND: Herein, the authors evaluated how the time to testosterone rebound (TTR) after radiotherapy (RT) and 6 months of androgen deprivation therapy (ADT) impacted the risk of prostate cancer-specific mortality (PCSM) and cardiovascular-specific mortality (CVM) among men with varying comorbidity extent. METHODS: Between 1995 and 2001, a total of 206 men who were randomized to receive RT either alone or with 6 months of ADT for unfavorable-risk PC and who had a comorbidity score assigned using the Adult Comorbidity Evaluation 27 metric comprised the study cohort...
January 16, 2018: Cancer
https://www.readbyqxmd.com/read/29330472/amyloid-deposition-in-a-mouse-model-humanized-at-the-transthyretin-and-retinol-binding-protein-4-loci
#2
Xiangshun Li, Yanyi Lyu, Jingling Shen, Yanshuang Mu, Lixia Qiang, Li Liu, Kimi Araki, Bruno P Imbimbo, Ken-Ichi Yamamura, Shoude Jin, Zhenghua Li
Familial amyloidotic polyneuropathy is an autosomal dominant disorder caused by a point mutation in the transthyretin (TTR) gene. The process of TTR amyloidogenesis begins with rate-limiting dissociation of the TTR tetramer. Thus, the TTR stabilizers, such as Tafamidis and Diflunisal, are now in clinical trials. Mouse models will be useful to testing the efficacy of these drugs. Although several mouse models have been generated, they all express mouse Rbp4. Thus, human TTR associates with mouse RBP4, resulting in different kinetic and thermodynamic stability profiles of TTR tetramers...
January 12, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29329798/efficacy-of-warfarin-anticoagulation-and-incident-dementia-in-a-community-based-cohort-of-atrial-fibrillation
#3
Malini Madhavan, Tiffany Y Hu, Bernard J Gersh, Veronique L Roger, Jill Killian, Susan A Weston, Jonathan Graff-Radford, Samuel J Asirvatham, Alanna M Chamberlain
OBJECTIVE: To study the association between time in therapeutic range (TTR) during warfarin therapy and risk of dementia in a population-based cohort of incident atrial fibrillation (AF). PATIENTS AND METHODS: We conducted an observational population-based study of 2800 nondemented patients with incident AF from January 1, 2000, through December 31, 2010. The association of incident dementia with warfarin therapy and TTR was examined using Cox proportional hazards regression models...
January 9, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29316055/dedicated-warfarin-care-programme-results-in-superior-warfarin-control-in-queensland-australia
#4
Nijole Bernaitis, Tony Badrick, Shailendra Anoopkumar-Dukie
BACKGROUND: Warfarin is used to prevent stroke in patients with atrial fibrillation (AF). Ongoing monitoring of International normalised ratio (INR) and time in therapeutic range (TTR) commonly used to assess the quality of warfarin management are required. Anticoagulant clinics have demonstrated improved TTRs, particularly in countries with poorer control in primary care settings. Reported TTR in Australia has been relatively high; so, it is unknown if benefit would be seen from dedicated warfarin clinics in Australia...
January 9, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29313558/quality-control-of-oral-anticoagulation-with-vitamin-k-antagonists-in-primary-care-patients-in-poland-a-multi-centre-study
#5
Jolanta Sawicka-Powierza, Krzysztof Buczkowski, Sławomir Chlabicz, Zbigniew Gugnowski, Katarzyna Powierza, Alicja Małgorzata Ołtarzewska
BACKGROUND: Vitamin K antagonists (VKA) remain the mainstay of anticoagulation therapy, which requires monitoring of international normalised ratio (INR). Quality of oral anticoagulation, clinical benefits and the risk related to VKA application are determined by time in the therapeutic range (TTR). AIM: The aim of this study was to assess the therapeutic quality of oral anticoagulation and to determine factors that affect the incidence of INR outside the recommended range in primary care patients undergoing long-term VKAs therapy in Poland...
January 9, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29310600/warfarin-anticoagulation-in-hemodialysis-patients-with-atrial-fibrillation-comparison-of-nephrologist-led-and-anticoagulation-clinic-led-management
#6
Hamad Bahbahani, Ahmed AlTurki, Ahmed Dawas, Mark L Lipman
BACKGROUND: There is conflicting evidence of benefit versus harm for warfarin anticoagulation in hemodialysis patients with atrial fibrillation. This equipoise may be explained by suboptimal Time in Therapeutic Range (TTR), which correlates well with thromboembolic and bleeding complications. This study aimed to compare nephrologist-led management of warfarin therapy versus that led by specialized anticoagulation clinic. METHODS: In a retrospective cohort of chronic hemodialysis patients from two institutions (Institution A: Nephrologist-led warfarin management, Institution B: Anticoagulation clinic-led warfarin management), we identified patients with atrial fibrillation who were receiving warfarin for thromboembolic prophylaxis...
January 8, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29310464/annals-express-unwanted-road-to-anemia-in-transthyretin-familial-amyloid-polyneuropathy-may-continue-irrespective-of-tafamidis-treatment
#7
Tokunori Ikeda, Teruaki Masuda, Mitsuharu Ueda, Taro Yamashita, Yohei Misumi, Satoru Shinriki, Yukio Ando
BACKGROUND: This retrospective longitudinal study was performed to determine whether tafamidis treatment leads to improvements in commonly used blood data for transthyretin familial amyloid polyneuropathy (TTR-FAP). METHODS: Commonly used blood data (complete blood count [including a hemogram], total protein, albumin, blood urea nitrogen, creatinine, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase, γ-glutamyl transpeptidase, total bilirubin [T-Bil], creatine kinase, choline esterase, high density lipoprotein cholesterol, low density lipoprotein cholesterol, estimated glomerular filtration rate [eGFR], serum amyloid A protein, TTR, hemoglobin A1c, free triiodothyronine [FT3], and free thyroxine [FT4]) were investigated in 33 TTR-FAP patients...
January 1, 2018: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29309860/effects-of-total-saponins-from-trillium-tschonoskii-rhizome-on-grey-and-white-matter-injury-evaluated-by-quantitative-multiparametric-mri-in-a-rat-model-of-ischemic-stroke
#8
Manzhong Li, Junyao Ouyang, Yi Zhang, Brian Chi Yan Cheng, Yu Zhan, Le Yang, Haiyan Zou, Hui Zhao
ETHNOPHARMACOLOGICAL RELEVANCE: Trillium tschonoskii rhizome (TTR), a medicinal herb, has been traditionally used to treat traumatic brain injury and headache in China. Although the potential neuroprotective efficacy of TTR has gained increasing interest, the pharmacological mechanism remains unclear. Steroid saponins are the main bioactive components of the herb. AIM OF THE STUDY: To investigate the protective and repair-promoting effects of the total saponins from TTR (TSTT) on grey and white matter damages in a rat model of middle cerebral artery occlusion (MCAO) using magnetic resonance imaging (MRI) assay...
January 5, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29308774/a-comparison-of-dabigatran-and-warfarin-for-stroke-prevention-in-elderly-asian-population-with-nonvalvular-atrial-fibrillation-an-audit-of-current-practice-in-malaysia
#9
S H Yap, Y P Ng, A Roslan, J Kolanthaivelu, K W Koh, H S P'ng, Y L Boo, F K Hoo, L B Yap
INTRODUCTION: Atrial fibrillation (AF) is the most common cardiac arrhythmia with significant morbidity and mortality in relation to thromboembolic stroke. Our study aimed to evaluate the safety and efficacy of dabigatran in stroke prevention in elderly patient with nonvalvular AF with regard to the risk of ischemic stroke and intracranial haemorrhage (ICH) in real-world setting. METHODS: A retrospective cohort study of 200 patients on dabigatran and warfarin from January 2009 till September 2016 was carried out...
December 2017: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/29306122/exploration-of-adherence-and-patient-experiences-with-doacs-one-year-after-switching-from-vitamin-k-antagonists-insights-from-the-switching-study
#10
John K Bartoli-Abdou, Jignesh P Patel, Jacob Crawshaw, Bipin Vadher, Alison Brown, Lara N Roberts, Raj K Patel, Roopen Arya, Vivian Auyeung
BACKGROUND: Current UK and European guidelines recommend anticoagulated patients prescribed warfarin with time in therapeutic range (TTR) <65% be considered for DOAC therapy. There has been considerable concern that adherence with DOACs may be poor compared with warfarin. Little is known about the patient experience of switching from warfarin to DOAC and how patients manage their DOAC long term. Our aim was to conduct focus groups exploring patient's previous experiences with warfarin, their current experience with DOACs, their adherence to DOACs and the long-term service provision they envisage...
January 2, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29303515/on-the-origin-of-high-temperature-phenomena-in-pt-al2o3
#11
Alexander S Lisitsyn, Olga A Yakovina
Treatments of Pt/γ-Al2O3 with H2 under harsh conditions have long been known to strongly influence the properties of this important catalytic system, but the true causes of the high-temperature effects still remain unclear. We have performed a more detailed study of this issue, having used H2-TPD as a sensitive probe of metal-support interactions. The experimental results are in accordance with previous studies and demonstrate strong changes in adsorption and catalytic properties of Pt/γ-Al2O3 after high-temperature H2 treatments, as well as the possibility to reverse the changes, completely or in part, through O2 and H2O treatments...
January 5, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29290976/neuron-derived-transthyretin-modulates-astrocytic-glycolysis-in-hormone-independent-manner
#12
Alina Zawiślak, Piotr Jakimowicz, James A McCubrey, Dariusz Rakus
It has been shown that neurons alter the expression of astrocytic metabolic enzymes by secretion of until now unknown molecule(s) into extracellular fluid. Here, we present evidence that neuron-derived transthyretin (TTR) stimulates expression of glycolytic enzymes in astrocytes which is reflected by an increased synthesis of ATP. The action of TTR is restricted to regulatory enzymes of glycolysis: phosphofructokinase P (PFKP) and pyruvate kinase M1/M2 isoforms (PKM1/2). The regulation of PFK and PKM expression by TTR is presumably specific for brain tissue and is independent of the role of TTR as a carrier protein for thyroxine and retinol...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29288430/co-precipitation-molecules-hemopexin-and-transferrin-may-be-key-molecules-for-fibrillogenesis-in-ttr-v30m-amyloidogenesis
#13
Mika Ohta, Aki Sugano, Naoya Hatano, Hirotaka Sato, Hirofumi Shimada, Hitoshi Niwa, Toshiyuki Sakaeda, Hajime Tei, Yoshiyuki Sakaki, Ken-Ichi Yamamura, Yutaka Takaoka
The disease model of familial amyloidotic polyneuropathy-7.2-hMet30 mice-manifests amyloid deposition that consists of a human amyloidogenic mutant transthyretin (TTR) (TTR V30M). Our previous study found amyloid deposits in 14 of 27 7.2-hMet30 mice at 21-24 months of age. In addition, non-fibrillar TTR deposits were found in amyloid-negative 7.2hMet30 mice. These results suggested that TTR amyloidogenesis required not only mutant TTR but also an additional factor (or factors) as an etiologic molecule. To determine the differences in serum proteome in amyloid-positive and amyloid-negative mice in the 7...
December 29, 2017: Transgenic Research
https://www.readbyqxmd.com/read/29283575/in-vitro-and-in-silico-competitive-binding-of-brominated-polyphenyl-ether-contaminants-with-human-and-gull-thyroid-hormone-transport-proteins
#14
Katie L Hill, Åse-Karen Mortensen, Daniel Teclechiel, William G Willmore, Ingebrigt Sylte, Bjorn M Jenssen, Robert J Letcher
Tetradecabromo-1,4-diphenoxybenzene (TeDB-DiPhOBz) is a highly brominated additive flame retardant (FR). Debrominated photodegradates of TeDB-DiPhOBz are hydroxylated in vitro in liver microsomal assays based on herring gulls (Larus argentatus), including one metabolite identified as 4"-OH-2,2',2",4-tetrabromo-DiPhOBz. Chemically related methoxylated tetra- to hexabromo-DiPhOBzs are known contaminants in herring gulls. Collectively, nothing is currently known about biological effects of these polybrominated (PB) DiPhOBz-based compounds...
December 28, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29277593/oculoleptomeningeal-amyloidosis-secondary-to-the-rare-transthyretin-c-381t-g-p-ile127met-mutation
#15
Francois Mathieu, Erin Morgan, Joyce So, David G Munoz, Warren Mason, Paul Kongkham
BACKGROUND: Oculoleptomeningeal amyloidosis (OLMA) represents a rare subtype of familial transthyretin (TTR) amyloidosis, characterized by deposition of amyloid in cranial and spinal leptomeninges along with ocular involvement. Of more than 100 TTR mutations identified, few have been associated with OLMA. Herein we describe the first report of leptomeningeal amyloidosis associated with the c.381T>G (p.Ile127Met) TTR mutation, linking this variant in the OLMA phenotype. CASE DESCRIPTION: A 53 year-old male presented with a 2-year history of progressive symptoms including upper and lower limb weakness, ataxia, peripheral and autonomic neuropathy...
December 22, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29276917/-the-integrated-approach-to-improving-efficiency-and-safety-of-anticoagulation-therapy-in-patients-with-prosthetic-mitral-valve
#16
E V Gorbunova, R R Salakhov, Y N Odarenko, S E Mamchur
AIM: To assess advantages of integrated approach to improvement of efficiency and safety of warfarin therapy after heart valve replacement. MATERIALS AND METHODS: We included in this study 118 patients who had undergone simultaneous mitral valve replacement and maze procedure. Group 1 patients (n=37) underwent just sinus rhythm restoration, group 2 patients (n=54) underwent sinus rhythm restoration and participated in a patient education program, group 3 patients (n=27) underwent sinus rhythm restoration, participated in a patient education program, and were subjected to pharmacogenetic testing for warfarin sensitivity...
November 2017: Kardiologiia
https://www.readbyqxmd.com/read/29275824/predictors-of-survival-after-treatment-of-oligometastases-after-esophagectomy
#17
Galal Ghaly, Sebron Harrison, Mohamed K Kamel, Mohamed Rahouma, Abu Nasar, Jeffrey L Port, Brendon M Stiles, Nasser K Altorki
BACKGROUND: Recurrent esophageal carcinoma (EC) has a dismal prognosis. However, prior studies showed that selected patients with isolated recurrence may benefit from definitive therapy. The aim of this study was to identify the predictors of postrecurrence survival (PRS) in patients with isolated EC recurrence who were treated with curative intent. METHODS: A retrospective review of a prospective database (1988 to 2015) was performed to identify all recurrent EC patients after curative esophagectomy...
December 21, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29275065/reduced-time-in-therapeutic-range-and-higher-mortality-in-atrial-fibrillation-patients-taking-acenocoumarol
#18
José Miguel Rivera-Caravaca, Vanessa Roldán, María Asunción Esteve-Pastor, Mariano Valdés, Vicente Vicente, Francisco Marín, Gregory Y H Lip
PURPOSE: The efficacy and tolerability of vitamin K antagonists (VKAs) depends on the quality of anticoagulant control, reflected by the mean time in therapeutic range (TTR) of international normalized ratio 2.0 to 3.0. In the present study, we aimed to investigate the association between TTR and change in TTR (ΔTTR) with the risk of mortality and clinically significant events in a consecutive cohort of atrial fibrillation (AF) patients. METHODS: We included 1361 AF patients stable on VKAs (international normalized ratio 2...
December 20, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/29260507/safety-and-efficacy-of-daratumumab-in-combination-with-bortezomib-and-dexamethasone-in-japanese-patients-with-relapsed-or-refractory-multiple-myeloma
#19
Shinsuke Iida, Tatsuo Ichinohe, Atsushi Shinagawa, Kenshi Suzuki, Naoki Takezako, Masayuki Aoki
Daratumumab in combination with bortezomib and dexamethasone (DVd) has demonstrated longer progression-free survival than combination of bortezomib and dexamethasone in patients with relapsed or refractory multiple myeloma (RRMM). In this multicenter, open-label, phase-1 study, the safety, efficacy, and pharmacokinetics (PK) of DVd were evaluated in Japanese patients with RRMM. Eight patients with RRMM aged between 54 and 82 years were enrolled and treated with DVd regimen. Primary endpoints were tolerability and safety...
December 19, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/29259905/negative-effects-of-transthyretin-in-high-myopic-vitreous-on-diabetic-retinopathy
#20
Jun Shao, Yong Yao
AIM: To analyze the relationship between vitreous transthyretin (TTR) levels, high myopia and diabetic retinopathy (DR). METHODS: We selected 6722 individuals from the southern Jiangsu Province for diabetes and ophthalmic examinations. The TTR concentration in the vitreous of 50 patients with high myopia and diabetes, 50 patients with only DR, and 20 healthy controls were determined by ELISA. Key factors in Tie2 pathway in DR development including vascular endothecial growth factor (VEGF), Tie2, Angpt1, Angpt2, vascular endothelial growth factor receptor (VEGFR) 1 and VEGFR2 were also detected by ELISA...
2017: International Journal of Ophthalmology
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