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https://www.readbyqxmd.com/read/28531963/mir-19b-and-mir-16-cooperatively-signaling-target-the-regulator-adra1a-in-hypertensive-heart-disease
#1
Liping He, Congxin Huang
BACKGROUND: Hypertensive heart disease (HHD) is one of the most important causes of disease-related deaths worldwide and brings great painful for patients. In recent years, increasingly evidences support the role of miRNAs in various physiology processes and human diseases. In the present study, we investigated whether ADRA1A regulated by miR-19b and miR-16 was involved in the pathogenic mechanism of HHD. METHODS: HHD mice models were established with injection of Deoxycorticosterone acetate (Doca)...
May 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28530078/-athlete-s-heart-the-more-the-merrier
#2
REVIEW
Reut Shavit, Michael Glikson, Naama Constantini
Regular moderate exercise training is effective for the prevention and treatment of many common chronic diseases and improves cardiovascular health and life expectancy. However, long-term excessive endurance exercise may induce pathological structural remodeling of the heart. The athlete's heart is characterized by enlargement of cardiac chambers and eccentric hypertrophy with preserved myocardial function as normal physiological adaptations for prolonged and intense endurance physical stress. However, recent studies have demonstrated transient right ventricular dysfunction and elevation of cardiac biomarkers following intense endurance exercise...
September 2016: Harefuah
https://www.readbyqxmd.com/read/28529484/targeting-adenosine-receptors-for-the-treatment-of-cardiac-fibrosis
#3
REVIEW
Elizabeth A Vecchio, Paul J White, Lauren T May
Adenosine is a ubiquitous molecule with key regulatory and cytoprotective mechanisms at times of metabolic imbalance in the body. Among a plethora of physiological actions, adenosine has an important role in attenuating ischaemia-reperfusion injury and modulating the ensuing fibrosis and tissue remodeling following myocardial damage. Adenosine exerts these actions through interaction with four adenosine G protein-coupled receptors expressed in the heart. The adenosine A2B receptor (A2BAR) is the most abundant adenosine receptor (AR) in cardiac fibroblasts and is largely responsible for the influence of adenosine on cardiac fibrosis...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28526264/celecoxib-aggravates-cardiac-apoptosis-in-l-name-induced-pressure-overload-model-in-rats-immunohistochemical-determination-of-cardiac-caspase-3-mcl-1-bax-and-bcl-2
#4
Sarah M Mosaad, Sawsan A Zaitone, Abdelazim Ibrahim, Amani A El-Baz, Dina M Abo-Elmatty, Yasser M Moustafa
The mechanism of celecoxib cardiovascular adverse events was earlier investigated; yet in-depth investigations are needed to assess the involvement of its pro-apoptotic effect throughout this process. An in-vivo chronic rat model of pressure overload employing Nʷ-nitro-l-arginine methyl ester (L-NAME) was tested at different time intervals to ensure the occurrence of persistent myocardial apoptosis along with pressure overload. Seven groups of male Wistar rats were assigned as (i) distilled water; (ii-iv) L-NAME (60 mg/kg) for 6, 12 or 16 weeks; (v-vii) L-NAME [16 weeks] + celecoxib (25, 50 or 100 mg/kg), from week 13 to week 16...
May 16, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28525896/activation-of-cannabinoid-receptor-type-ii-by-am1241-protects-adipose-derived-mesenchymal-stem-cells-from-oxidative-damage-and-enhances-their-therapeutic-efficacy-in-myocardial-infarction-mice-via-stat3-activation
#5
Dong Han, Xiang Li, Wen-Si Fan, Jiang-Wei Chen, Tian-Tian Gou, Tao Su, Miao-Miao Fan, Meng-Qi Xu, Ya-Bin Wang, Sai Ma, Ya Qiu, Feng Cao
The poor survival of cells in ischemic sites diminishes the therapeutic efficacy of stem cell therapy. Previously we and others have reported that Cannabinoid receptor type II (CB2) is protective during heart ischemic injury for its anti-oxidative activity. However, whether CB2 activation could improve the survival and therapeutic efficacy of stem cells in ischemic myocardium and the underlying mechanisms remain elusive. Here, we showed evidence that CB2 agonist AM1241 treatment could improve the functional survival of adipose-derived mesenchymal stem cells (AD-MSCs) in vitro as well as in vivo...
May 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28524367/transplantation-of-human-villous-trophoblasts-preserves-cardiac-function-in-mice-with-acute-myocardial-infarction
#6
Zegen Wang, Ningzheng Dong, Yayan Niu, Zhiwei Zhang, Ce Zhang, Meng Liu, Tiantian Zhou, Qingyu Wu, Ke Cheng
Over the past decade, cell therapies have provided promising strategies for the treatment of ischaemic cardiomyopathy. Particularly, the beneficial effects of stem cells, including bone marrow stem cells (BMSCs), endothelial progenitor cells (EPCs), mesenchymal stem cells (MSCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs), have been demonstrated by substantial preclinical and clinical studies. Nevertheless stem cell therapy is not always safe and effective. Hence, there is an urgent need for alternative sources of cells to promote cardiac regeneration...
May 19, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28522755/increased-left-ventricular-extracellular-volume-and-enhanced-twist-function-in-type-1-diabetic-individuals
#7
Zainisha Vasanji, Ronald J Sigal, Neil Derek Eves, Debra L Isaac, Matthias G Friedrich, Kelvin Chow, Richard B Thompson
Individuals with type 1 diabetes (T1D) characteristically have high glycemic levels that over time can result in reactive fibrosis and abnormalities in myocardial function. T1 mapping with magnetic resonance imaging (MRI) can estimate the extent of reactive fibrosis by measurement of the extracellular volume fraction (ECV). The extent of alterations in the ECV and associated changes in left ventricular (LV) function and morphology in individuals with T1D is unknown. Fourteen individuals with long-term T1D and fourteen sex-, age-, and body mass index-matched controls without diabetes underwent MRI measurement of myocardial T1 and ECV values as well as LV function and morphology...
May 18, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28522072/cardiovascular-magnetic-resonance-in-systemic-sclerosis-pearls-and-pitfalls
#8
REVIEW
Sophie I Mavrogeni, Juerg Schwitter, Luna Gargani, Alessia Pepe, Lorenzo Monti, Yannick Allanore, Marco Matucci-Cerinic
Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular dysfunction and excessive fibrosis, involving internal organs including the heart. The estimated prevalence of cardiac involvement in SSc is high and remains subclinical until the late stages. It is either primary, related to myocardial inflammation and fibrosis, or secondary, due to pulmonary arterial hypertension (SSc-PAH) or systemic hypertension, in those patients with renal involvement. Cardiovascular magnetic resonance (CMR) is a useful tool for the early assessment of cardiac involvement in SSc...
March 31, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28512159/employing-extracellular-volume-cardiovascular-magnetic-resonance-measures-of-myocardial-fibrosis-to-foster-novel-therapeutics
#9
Erik B Schelbert, Hani N Sabbah, Javed Butler, Mihai Gheorghiade
Quantifying myocardial fibrosis (MF) with myocardial extracellular volume measures acquired during cardiovascular magnetic resonance promises to transform clinical care by advancing pathophysiologic understanding and fostering novel therapeutics. Extracellular volume quantifies MF by measuring the extracellular compartment depicted by the myocardial uptake of contrast relative to plasma. MF is a key domain of dysfunctional but viable myocardium among others (eg, microvascular dysfunction and cardiomyocyte/mitochondrial dysfunction)...
June 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28507082/association-between-diffuse-myocardial-fibrosis-and-diastolic-dysfunction-in-sickle-cell-anemia
#10
Omar Niss, Robert Fleck, Fowe Makue, Tarek Alsaied, Payal Desai, Jeffrey A Towbin, Punam Malik, Michael D Taylor, Charles T Quinn
Sickle cell anemia (SCA)-related cardiomyopathy is characterized by diastolic dysfunction and hyperdynamic features. Diastolic dysfunction portends early mortality in SCA. Diastolic dysfunction is associated with microscopic myocardial fibrosis in SCA mice, but the cause of diastolic dysfunction in humans with SCA is unknown. We used cardiac magnetic resonance (CMR) measurements of extracellular volume fraction (ECV) to discover and quantify diffuse myocardial fibrosis in 25 individuals with SCA (mean age 23±13 years), and determine the association between diffuse myocardial fibrosis and diastolic dysfunction...
May 15, 2017: Blood
https://www.readbyqxmd.com/read/28501115/postconditioning-attenuates-coronary-perivascular%C3%A2-and-interstitial-fibrosis-through-modulating-angiotensin-ii-receptors-and-angiotensin-converting-enzyme-2-after-myocardial-infarction
#11
Zhang-Feng Wang, Ning-Ping Wang, Suzanna Harmouche, Tiji Philip, Xue-Fen Pang, Feng Bai, Zhi-Qing Zhao
BACKGROUND: Postconditioning (Postcon) is known to reduce infarct size. This study tested the hypothesis that Postcon attenuates the perivascular and interstitial fibrosis after myocardial infarction through modulating angiotensin II-activated fibrotic cascade. MATERIALS AND METHODS: Male Sprague-Dawley rats were subjected to 45-min coronary occlusion followed by 1 and 6 wk of reperfusion. Postcon was applied at the onset of reperfusion with four cycles of 10/10-s reperfusion-ischemia at the onset of reperfusion...
May 1, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28499247/nlrc5-deficiency-promotes-myocardial-damage-induced-by-high-fat-diet-in-mice-through-activating-tlr4-nf-%C3%AE%C2%BAb
#12
Shu-Ren Ma, Xiong-Wei Xie
The metabolic syndrome could be induced by high fat diet, leading to cardiovascular diseases, such as myocardial damage. Inflammation response and oxidative stress have been reported to be involved in high fat-induced heart injury, and the molecular mechanism is not fully understood. The NOD-like protein family member, NLRC5, could interact with IKKα to inhibit IKK complex activation. In our study, high fat diet-feeding mice showed cardiac fibrosis, inflammation and oxidative stress through collagen accumulation, TLR4/NF-κB and MAPKs signaling pathways activation...
May 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28497231/t2-mapping-and-t2-imaging-in-heart-failure
#13
REVIEW
A S Lota, P D Gatehouse, R H Mohiaddin
Cardiovascular magnetic resonance (CMR) is a versatile imaging modality that enables aetiological assessment and provides additional information to that of standard echocardiography in a significant proportion of patients with heart failure. In addition to highly accurate and reproducible assessment of ventricular volumes and replacement fibrosis, multiparametric mapping techniques have rapidly evolved to further expand the diagnostic and prognostic applications in various conditions ranging from acute inflammatory and ischaemic cardiomyopathy, to cardiac involvement in systemic diseases such as sarcoidosis and iron overload cardiomyopathy...
May 11, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28494028/rosemary-supplementation-rosmarinus-oficinallis-l-attenuates-cardiac-remodeling-after-myocardial-infarction-in-rats
#14
Bruna Paola Murino Rafacho, Priscila Portugal Dos Santos, Andréa de Freitas Gonçalves, Ana Angélica Henrique Fernandes, Katashi Okoshi, Fernanda Chiuso-Minicucci, Paula S Azevedo, Leonardo Antonio Mamede Zornoff, Marcos Ferreira Minicucci, Xiang-Dong Wang, Sergio Alberto Rupp de Paiva
BACKGROUND: Myocardial infarction (MI) is one of the leading causes of morbidity and mortality worldwide. Dietary intervention on adverse cardiac remodeling after MI has significant clinical relevance. Rosemary leaves are a natural product with antioxidant/anti-inflammatory properties, but its effect on morphology and ventricular function after MI is unknown. METHODS AND RESULTS: To determine the effect of the dietary supplementation of rosemary leaves on cardiac remodeling after MI, male Wistar rats were divided into 6 groups after sham procedure or experimental induced MI: 1) Sham group fed standard chow (SR0, n = 23); 2) Sham group fed standard chow supplemented with 0...
2017: PloS One
https://www.readbyqxmd.com/read/28492933/myocardial-fibrosis-in-duchenne-and-becker-muscular-dystrophy-reply
#15
Marly Conceição Silva, Clerio Francisco Azevedo, Carlos Eduardo Rochitte
No abstract text is available yet for this article.
May 10, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28492916/myocardial-fibrosis-in-duchenne-and-becker-muscular-dystrophy
#16
Robert C Bahler
No abstract text is available yet for this article.
May 10, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28490219/recruitment-of-macrophages-from-the-spleen-contributes-to-myocardial-fibrosis-and-hypertension-induced-by-angiotensin-ii
#17
Ning-Ping Wang, James Erskine, Wei-Wei Zhang, Rong-Hua Zheng, Li-Hui Zhang, Garret Duron, Julian Gendreau, Zhi-Qing Zhao
INTRODUCTION: The purpose of this study was to determine whether macrophages migrated from the spleen are associated with angiotensin II-induced cardiac fibrosis and hypertension. METHODS: Sprague-Dawley rats were subjected to angiotensin II infusion in vehicle (500 ng/kg/min) for up to four weeks. In splenectomy, the spleen was removed before angiotensin II infusion. In the angiotensin II AT1 receptor blockade, telmisartan was administered by gastric gavage (10 mg/kg/day) during angiotensin II infusion...
April 2017: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://www.readbyqxmd.com/read/28489954/astaxanthin-prevented-oxidative-stress-in-heart-and-kidneys-of-isoproterenol-administered-aged-rats
#18
Mohammad Nazmul Alam, Md Murad Hossain, Md Mizanur Rahman, Nusrat Subhan, Md Abdullah Al Mamun, Anayt Ulla, Hasan Mahmud Reza, Md Ashraful Alam
The objective of this study was to investigate the effect of astaxanthin on isoproterenol (ISO)-induced myocardial infarction and cardiac hypertrophy in rats. To evaluate the effect of astaxanthin on ISO-induced cardiac dysfunction, 18 aged Long Evans male rats were evenly divided into three groups. Group I (Control group) was given only the laboratory-ground food and normal water. Group II (ISO group) was administered ISO at a dose of 50 mg/kg subcutaneously (SC) twice a week for two weeks. Group III (Astaxanthin + ISO group) was treated with astaxanthin (25 mg/kg) orally every day and ISO 50 mg/kg SC twice a week for two weeks...
May 10, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28489579/transforming-growth-factor-%C3%AE-a-potential-biomarker-and-therapeutic-target-of-ventricular-remodeling
#19
REVIEW
Yuan Ma, Hai Zou, Xing-Xing Zhu, Jie Pang, Qiang Xu, Qin-Yang Jin, Ya-Hui Ding, Bing Zhou, Dong-Sheng Huang
Transforming growth factor β (TGF-β) is a multifunctional cytokine that is synthesized by many types of cells and regulates the cell cycle. Increasing evidence has led to TGF-β receiving increased and deserved attention in recent years because it may play a potentially novel and critical role in the development and progression of myocardial fibrosis and the subsequent progress of ventricular remodeling (VR). Numerous studies have highlighted a crucial role of TGF-β in VR and suggest potential therapeutic targets of the TGF-β signaling pathways for VR...
April 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28484397/current-understanding-of-the-pathophysiology-of-myocardial-fibrosis-and-its-quantitative-assessment-in-heart-failure
#20
REVIEW
Tong Liu, Deli Song, Jianzeng Dong, Pinghui Zhu, Jie Liu, Wei Liu, Xiaohai Ma, Lei Zhao, Shukuan Ling
Myocardial fibrosis is an important part of cardiac remodeling that leads to heart failure and death. Myocardial fibrosis results from increased myofibroblast activity and excessive extracellular matrix deposition. Various cells and molecules are involved in this process, providing targets for potential drug therapies. Currently, the main detection methods of myocardial fibrosis rely on serum markers, cardiac magnetic resonance imaging, and endomyocardial biopsy. This review summarizes our current knowledge regarding the pathophysiology, quantitative assessment, and novel therapeutic strategies of myocardial fibrosis...
2017: Frontiers in Physiology
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