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https://www.readbyqxmd.com/read/29243457/the-surgical-management-of-obesity
#1
Samuel Torres-Landa, Umashankkar Kannan, Isabella Guajardo, Octavia E Pickett-Blakely, Daniel T Dempsey, Noel N Williams, Kristoffel R Dumon
Obesity is a spreading epidemic associated with significant morbidity and mortality with a prevalence of over 36% worldwide. In the face of a growing epidemic, increasing medical costs, and the disappointing limitations of medical and lifestyle modification bariatric surgery was found to consistently lead to significant weight loss and improvement in obesity-associated comorbidities when compared to non-surgical interventions. Bariatric procedures fall within three basic categories: restrictive procedures, malabsorptive procedures, and procedures that combine both restrictive and malabsorptive mechanisms...
December 14, 2017: Minerva Chirurgica
https://www.readbyqxmd.com/read/29243396/bariatric-surgery-induced-cardiac-and-lipidomic-changes-in-obesity-related-heart-failure-with-preserved-ejection-fraction
#2
Deana Mikhalkova, Sujata R Holman, Hui Jiang, Mohammed Saghir, Eric Novak, Andrew R Coggan, Robert O'Connor, Adil Bashir, Ali Jamal, Daniel S Ory, Jean E Schaffer, J Christopher Eagon, Linda R Peterson
OBJECTIVE: To determine the effects of gastric bypass on myocardial lipid deposition and function and the plasma lipidome in women with obesity and heart failure with preserved ejection fraction (HFpEF). METHODS: A primary cohort (N = 12) with HFpEF and obesity underwent echocardiography and magnetic resonance spectroscopy both before and 3 months and 6 months after bariatric surgery. Plasma lipidomic analysis was performed before surgery and 3 months after surgery in the primary cohort and were confirmed in a validation cohort (N = 22)...
December 15, 2017: Obesity
https://www.readbyqxmd.com/read/29243145/the-first-consensus-statement-on-one-anastomosis-mini-gastric-bypass-oagb-mgb-using-a-modified-delphi-approach
#3
Kamal K Mahawar, Jacques Himpens, Scott A Shikora, Jean-Marc Chevallier, Mufazzal Lakdawala, Maurizio De Luca, Rudolf Weiner, Ali Khammas, Kuldeepak Singh Kular, Mario Musella, Gerhard Prager, Mohammad Khalid Mirza, Miguel Carbajo, Lilian Kow, Wei-Jei Lee, Peter K Small
BACKGROUND: An increasing number of surgeons worldwide are now performing one anastomosis/mini gastric bypass (OAGB/MGB). Lack of a published consensus amongst experts may be hindering progress and affecting outcomes. This paper reports results from the first modified Delphi consensus building exercise on this procedure. METHODS: A committee of 16 recognised opinion-makers in bariatric surgery with special interest in OAGB/MGB was constituted. The committee invited 101 OAGB/MGB experts from 39 countries to vote on 55 statements in areas of controversy or variation associated with this procedure...
December 14, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29239343/surgery-and-considerations-for-the-repair-of-petersen-s-space-hernia-after-mini-gastric-bypass
#4
Borja Camacho Fernández-Pacheco, Eudaldo López-Tomassetti Fernández, Juan Ramón Hernández Hernández
This paper reports a case of Petersen's space hernia after mini gastric bypass. This is an anecdotal post-operative complication in the mini gastric bypass technique, with an estimated rate of 1/5000 cases. Similar cases described in the literature were treated by the surgical hernia reduction and the closure of the mesenteric defect. Our patient had a unique management, performing a conversion to Roux-en-Y gastric bypass with dissection of the biliopancreatic limb at the anastomosis and creation of a variable foot-point anastomosis with excellent mid-term post-operative results...
January 2018: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29237132/anastomotic-stricture-rates-following-roux-en-y-gastric-bypass-for-morbid-obesity-a-comparison-between-linear-and-circular-stapled-anastomosis
#5
Harbi Khalayleh, Guy Pines, Ashraf Imam, Shimon Sapojnikov, Victor Buyeviz, Eli Mavor
BACKGROUND: Laparoscopic Roux-en-Y gastric bypass (LRYGB) is an effective procedure in the management of morbid obesity with variations in outcome, which are technique dependent. Anastomotic stricture remains an important complication. The aim of this study was to assess the long-term outcome of patients undergoing either a linear-stapled anastomosis (LSA) or circular-stapled anastomosis (CSA) with an emphasis on postoperative stricture formation and excess body weight loss (EBWL). METHODS: Medical records of all patients who underwent bariatric surgery between 2008 and 2013 at a single bariatric surgical center were reviewed...
December 13, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29235126/relationships-of-serum-25-hydroxyvitamin-d-ionized-calcium-and-parathyroid-hormone-after-obesity-surgery
#6
Stephen Hewitt, Erlend Tuseth Aasheim, Torgeir Thorson Søvik, Jørgen Jahnsen, Jon Kristinsson, Erik Fink Eriksen, Tom Mala
OBJECTIVE: The high prevalence of secondary hyperparathyroidism (SHPT) after obesity surgery is a concern for long-term bone health. Limited knowledge exists about optimal vitamin D and suppression of parathyroid hormone (PTH) after these procedures. The aim of this study was to investigate the prevalence of SHPT and its relation to vitamin D status. DESIGN: A cross-sectional study at Oslo University Hospital, Norway. PATIENTS: 502 consecutive patients, age 22-64 years, attending 2-year follow-up after Roux-en-Y gastric bypass...
December 13, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29235012/implications-of-celiac-disease-among-patients-undergoing-gastric-bypass
#7
Lindsey M Freeman, Andrew T Strong, Gautam Sharma, Suriya Punchai, John H Rodriguez, Donald F Kirby, Matthew Kroh
INTRODUCTION: Bariatric surgery is generally safe and effective, but co-existing malabsorptive processes may increase the risk of complications or nutritional deficiencies. Bariatric surgery has not been well studied in the setting of pre-existing celiac disease. MATERIALS AND METHODS: Patients who underwent Roux-en-Y gastric bypass (RYGB) from January 2002 to December 2015 were retrospectively reviewed for either diagnosis of or serum testing for celiac disease...
December 12, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29235010/metabolic-changes-up-to-10%C3%A2-years-after-gastric-bypass
#8
Daniela Vicinansa Mônaco-Ferreira, Vânia Aparecida Leandro-Merhi, Nilton César Aranha, Andre Brandalise, Nelson Ary Brandalise
OBJECTIVE: The aim of this study was to investigate the lipid and glycemic profiles of patients up to 10 years after Roux-en-Y gastric bypass. METHOD: A retrospective, longitudinal study was conducted at a multidisciplinary center for the treatment of obesity in the state of São Paulo, Brazil. The study included 150 patients submitted to unbanded laparoscopic Roux-en-Y gastric bypass. The metabolic profile included total cholesterol and fractions, triglycerides, and fasting glucose...
December 12, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29229970/regression-to-the-mean-apparent-data-errors-and-biologically-extraordinary-results-letter-regarding-changes-in-telomere-length-3-5-years-after-gastric-bypass-surgery
#9
D L Smith, D M Thomas, C O Siu, S Verhulst, D B Allison
International Journal of Obesity accepted article preview online, 12 December 2017. doi:10.1038/ijo.2017.298.
December 12, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29228941/four-years-follow-up-changes-of-physical-activity-and-sedentary-time-in-women-undergoing-roux-en-y-gastric-bypass-surgery-and-appurtenant-children
#10
Fanny Sellberg, Mikaela Willmer, Per Tynelius, Daniel Berglind
BACKGROUND: Objectively measured levels of physical activity (PA) in patients undergoing Roux-en-Y Gastric Bypass (RYGB) surgery remain essentially unchanged from before to one year after surgery. Effects from RYGB on objectively measured levels of PA among women undergoing RYGB and appurtenant children beyond one year post-surgery are unknown. The aim of the present study was to objectively assess longitudinal changes in PA and sedentary time (ST), among women undergoing RYGB and appurtenant children, from three months before to nine and 48 months after maternal surgery...
December 11, 2017: BMC Surgery
https://www.readbyqxmd.com/read/29228058/altered-intragenic-dna-methylation-of-hook2-gene-in-adipose-tissue-from-individuals-with-obesity-and-type-2-diabetes
#11
Sandra Rodríguez-Rodero, Edelmiro Menéndez-Torre, Gustavo Fernández-Bayón, Paula Morales-Sánchez, Lourdes Sanz, Estrella Turienzo, Juan José González, Ceferino Martinez-Faedo, Lorena Suarez-Gutiérrez, Jessica Ares, Lucia Díaz-Naya, Alicia Martin-Nieto, Juan L Fernández-Morera, Mario F Fraga, Elías Delgado-Álvarez
AIMS/HYPOTHESIS: Failure in glucose response to insulin is a common pathology associated with obesity. In this study, we analyzed the genome wide DNA methylation profile of visceral adipose tissue (VAT) samples in a population of individuals with obesity and assessed whether differential methylation profiles are associated with the presence of type 2 diabetes (T2D). METHODS: More than 485,000 CpG genome sites from VAT samples from women with obesity undergoing gastric bypass (n = 18), and classified as suffering from type 2 diabetes (T2D) or not (no type 2 diabetes, NT2D), were analyzed using DNA methylation arrays...
2017: PloS One
https://www.readbyqxmd.com/read/29225893/a-novel-approach-to-glycemic-control-in-type-2-diabetes-mellitus-partial-jejunal-diversion-pre-clinical-to-clinical-pathway
#12
Martin Fried, Karin Dolezalova, Adam P Chambers, Elliott J Fegelman, Robin Scamuffa, Michael L Schwiers, Jason R Waggoner, Martin Haluzik, Randy J Seeley
Objective: To explore partial jejunal diversion (PJD) via a side-to-side jejuno-jejunostomy for improved glycemic control in type 2 diabetes mellitus (T2DM). PJD is an anatomy-sparing, technically simple surgery in comparison to the predominate metabolic procedures, Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). Positive results in a rodent model prompted a human proof-of-concept study. Research design and methods: Pre-clinically, 71 rats were studied in a model of metabolic dysfunction induced by a high-fat diet; 33 animals undergoing one of two lengths of PJD were compared with 18 undergoing sham, 10 RYGB and 10 jejuno-ileal bypass...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29224241/cost-effectiveness-of-bariatric-surgery-in-adolescents-with-severe-obesity-in-the-uk
#13
M Panca, R M Viner, B White, T Pandya, H Melo, M Adamo, R Batterham, D Christie, S Kinra, S Morris
Evidence shows that surgery for severe obesity in adults improves health and psychological functioning, and is cost-effective. Data on bariatric surgery for adolescents with severe obesity are extremely limited, with no evidence on cost-effectiveness. We evaluated the lifetime cost-effectiveness of bariatric surgery compared with no surgery in adolescents with severe obesity from the UK's National Health Service perspective. Eighteen adolescents with body mass index ≥40 kg m-2 who underwent bariatric surgery (laparoscopic Roux en Y Gastric Bypass [RYGB] [N = 9], and laparoscopic Sleeve Gastrectomy [SG] [N = 9]) at University College London Hospitals between January 2008 and December 2013 were included...
December 10, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/29222767/platelet-counts-and-liver-enzymes-after-gastric-bypass-surgery
#14
Hans-Erik Johansson, Anna Wåhlén, Erica Aldenbäck, Arvo Haenni
BACKGROUND: Obesity is associated with chronic inflammation, liver steatosis and increased liver enzymes such as gamma-glutamyltransferase (GGT) and alanine aminotransferase (ALT), markers for non-alcoholic fatty liver disease (NAFLD) and liver fat content. Increased platelet counts (PCs) are a biomarker reflecting inflammation and the degree of fibrosis in NAFLD. We investigated alterations in PCs, GGT, ALT, C-reactive protein (CRP) and ferritin after Roux-en-Y gastric bypass (RYGBP)...
December 8, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29221786/access-to-excluded-structures-after-roux-en-y-gastric-bypass-experience-in-a-high-level-bariatric-center-without-a-technical-platform-for-endoscopic-retrograde-cholangiopancreatography
#15
D Verscheure, D Gianfranco, P Tammaro, J L Dumont, J P Marmuse, K Arapis
BACKGROUND: Rapid weight loss after bariatric surgery is associated with a high prevalence of gallstone formation. In laparoscopic Roux-en-Y gastric bypass (RYGBP), the bypassed segment is not readily available for endoscopic or radiographic examination. We propose a laparoscopic Janeway gastrostomy for secondary access to excluded structures in bariatric centers with no mandatory technical equipment in endoscopic retrograde cholangiopancreatography (ERCP), double-balloon ERCP or spiral enteroscopy...
December 5, 2017: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/29218660/how-bariatric-surgery-affects-liver-volume-and-fat-density-in-nafld-patients
#16
Ran B Luo, Toshiaki Suzuki, Jonathan C Hooker, Yesenia Covarrubias, Alexandra Schlein, Shanglei Liu, Jeffrey B Schwimmer, Scott B Reeder, Luke M Funk, Jacob A Greenberg, Guilherme M Campos, Bryan J Sandler, Santiago Horgan, Claude B Sirlin, Garth R Jacobsen
INTRODUCTION: Nonalcoholic fatty liver disease (NAFLD) is an epidemic in the obese population. Bariatric surgery is known to reverse multiple metabolic complications of obesity such as diabetes, dyslipidemia, and NAFLD, but the timing of liver changes has not been well described. MATERIALS AND METHODS: This was an IRB-approved, two-institutional prospective study. Bariatric patients received MRIs at baseline and after a pre-operative liquid diet. Liver biopsies were performed during surgery and if NAFLD positive, the patients received MRIs at 1, 3, and 6 months...
December 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29217131/omega-loop-gastric-bypass-is-more-effective-for-weight-loss-but-negatively-impacts-liver-enzymes-a-registry-based-comprehensive-first-year-analysis
#17
Hadar Spivak, Yaron Munz, Moshe Rubin, Itamar Raz, Tamy Shohat, Orit Blumenfeld
BACKGROUND: The impact of omega-loop gastric bypass (OLGB) on weight loss and liver enzymes remains inconclusive. OBJECTIVE: The aim of this study was to compare the impact of sleeve gastrectomy (SG), Roux-en-Y gastric bypass (RYGB), and OLGB on weight loss and liver enzyme levels. SETTING: National Bariatric Surgery Registry. METHODS: The study included 10,675 cases of SG, 1590 cases of RYGB, and 469 cases of OLGB that had available baseline and 1-year (12 ± 2 mo) follow-up data...
November 9, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29214306/seven-year-weight-trajectories-and-health-outcomes-in-the-longitudinal-assessment-of-bariatric-surgery-labs-study
#18
Anita P Courcoulas, Wendy C King, Steven H Belle, Paul Berk, David R Flum, Luis Garcia, William Gourash, Mary Horlick, James E Mitchell, Alfons Pomp, Walter J Pories, Jonathan Q Purnell, Ashima Singh, Konstantinos Spaniolas, Richard Thirlby, Bruce M Wolfe, Susan Z Yanovski
Importance: More information is needed about the durability of weight loss and health improvements after bariatric surgical procedures. Objective: To examine long-term weight change and health status following Roux-en-Y gastric bypass (RYGB) and laparoscopic adjustable gastric banding (LAGB). Design, Setting, and Participants: The Longitudinal Assessment of Bariatric Surgery (LABS) study is a multicenter observational cohort study at 10 US hospitals in 6 geographically diverse clinical centers...
December 6, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29208780/does-digestive-symptoms-require-esophago-gastroscopy-prior-to-bariatric-procedure-assessment-of-6-years-experience
#19
Serdar Yormaz, Kafali Yilmaz, Husnu Alptekin, Ilhan Ece, Fahrettin Acar, Bayram Colak, Mehmet Ertugrul Kafali, Enes Sahin, Mustafa Sahin
AIM: Performance of routine preoperative esophagogastroduodenal endoscopy (EGE) in patients undergoing bariatric surgery is still a controversial subject. The purpose of our study was to evaluate the benefits of performing preoperative EGE in a cohort of bariatric patients. MATERIAL AND METHODS: The present retrospective study was performed between March 2010 and June 2016. We divided the study participants into two groups: group A comprised subjects without disturbing upper digestive signs, while group B comprised patients with disturbing upper digestive signs...
November 29, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29208590/the-national-patient-centered-clinical-research-network-pcornet-bariatric-study-cohort-rationale-methods-and-baseline-characteristics
#20
Sengwee Toh, Laura J Rasmussen-Torvik, Emily E Harmata, Roy Pardee, Rosalinde Saizan, Elisha Malanga, Jessica L Sturtevant, Casie E Horgan, Jane Anau, Cheri D Janning, Robert D Wellman, R Yates Coley, Andrea J Cook, Anita P Courcoulas, Karen J Coleman, Neely A Williams, Kathleen M McTigue, David Arterburn, James McClay
BACKGROUND: Although bariatric procedures are commonly performed in clinical practice, long-term data on the comparative effectiveness and safety of different procedures on sustained weight loss, comorbidities, and adverse effects are limited, especially in important patient subgroups (eg, individuals with diabetes, older patients, adolescents, and minority patients). OBJECTIVE: The objective of this study was to create a population-based cohort of patients who underwent 3 commonly performed bariatric procedures-adjustable gastric band (AGB), Roux-en-Y gastric bypass (RYGB), and sleeve gastrectomy (SG)-to examine the long-term comparative effectiveness and safety of these procedures in both adults and adolescents...
December 5, 2017: JMIR Research Protocols
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