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https://www.readbyqxmd.com/read/28319997/intradiscal-glucocorticoid-injection-for-patients-with-chronic-low-back-pain-associated-with-active-discopathy-a-randomized-trial
#1
Christelle Nguyen, Isabelle Boutron, Gabriel Baron, Katherine Sanchez, Clémence Palazzo, Raphaël Benchimol, Guillaume Paris, Étienne James-Belin, Marie-Martine Lefèvre-Colau, Johann Beaudreuil, Jean-Denis Laredo, Anne Béra-Louville, Anne Cotten, Jean-Luc Drapé, Antoine Feydy, Philippe Ravaud, François Rannou, Serge Poiraudeau
Background: Active discopathy is associated with a specific phenotype of chronic low back pain (LBP). Local inflammation has a role in active discopathy-associated symptoms. Objective: To assess the efficacy of a single glucocorticoid intradiscal injection (GC IDI) in patients with chronic LBP with active discopathy. Design: Prospective, parallel-group, double-blind, randomized, controlled study. (ClinicalTrials.gov: NCT00804531). Setting: 3 tertiary care centers in France...
March 21, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28315179/decrements-in-health-related-quality-of-life-associated-with-gender-nonconformity-among-u-s-adolescents-and-young-adults
#2
Allegra R Gordon, Nancy Krieger, Cassandra A Okechukwu, Sebastien Haneuse, Mihail Samnaliev, Brittany M Charlton, S Bryn Austin
PURPOSE: Gender nonconformity, that is, transgressing conventionally "masculine" vs. "feminine" characteristics, is often stigmatized. Stigmatization and discrimination are social stressors that raise risk of adverse mental and physical health outcomes and may drive health inequities. However, little is known about the relationship between such social stressors and health-related quality of life (HRQOL). This paper aimed to examine associations between perceived gender nonconformity and HRQOL in a cohort of U...
March 17, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28315176/symptom-burden-and-life-challenges-reported-by-adult-chordoma-patients-and-their-caregivers
#3
Paula H Song, Hadi Beyhaghi, Josh Sommer, Antonia V Bennett
PURPOSE: This study aims to characterize the symptom burden and life challenges that chordoma patients and their caregivers experience. METHODS: In this cross-sectional study, we analyzed data from the Chordoma Foundation online community survey conducted in 2014. Frequency counts and percentages were calculated to determine the prevalence of self-reported symptoms and life challenges in the sample. We used Fisher's exact test to compare self-reported symptoms among subgroups with different disease status, tumor locations, and treatments received...
March 17, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28302534/experience-of-anti-vegf-treatment-and-clinical-levels-of-depression-and-anxiety-in-patients-with-wet-age-related-macular-degeneration
#4
Hugo Senra, Konstantinos Balaskas, Neda Mahmoodi, Tariq Aslam
PURPOSE: To investigate detailed patient experiences specific to receiving vascular endothelial growth factor inhibitors (anti-VEGF) for wet Age-Related Macular Degeneration (wAMD), and to acquire a snapshot of the frequency of clinically significant levels of depression, anxiety and post-traumatic stress among patients and levels of burden in patients' carers. DESIGN: Observational cross-sectional mixed-methods study METHODS: 300 patients with wAMD receiving anti-VEGF treatment and 100 patient carers were recruited...
March 13, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28301977/cognitive-complaints-in-women-with-fibromyalgia-are-they-due-to-depression-or-to-objective-cognitive-dysfunction
#5
Olga Gelonch, Maite Garolera, Joan Valls, Lluís Rosselló, Josep Pifarré
INTRODUCTION: Cognitive complaints are common in fibromyalgia, but it is unclear whether they represent an objective cognitive dysfunction or whether they could be explained by depressive symptoms. Here, we aim to elucidate the frequency of subjective cognitive complaints in a sample of women with fibromyalgia, in addition to analyzing associations between these subjective complaints and objective measures linked to the attention and executive cognitive domains. Finally, we aim to investigate the ability of demographic, clinical, and psychological variables to explain the subjective complaints observed...
March 17, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28301432/patient-reported-outcomes-of-quality-of-life-functioning-and-gi-psychiatric-symptom-severity-in-patients-with-inflammatory-bowel-disease-ibd
#6
Waguih W IsHak, Dana Pan, Alexander J Steiner, Edward Feldman, Amy Mann, James Mirocha, Itai Danovitch, Gil Y Melmed
BACKGROUND: Patients with inflammatory bowel disease (IBD) are at risk for psychiatric disorders that impact symptom experience and health-related quality of life (HRQOL). Therefore, comprehensive biopsychosocial assessments should be considered in ambulatory care settings. Patient-Reported Outcomes Measurement Information System (PROMIS) measures created by the National Institutes of Health have shown construct validity in a large IBD internet-based cohort, but their validity in ambulatory settings has not been examined...
March 15, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28299918/worry-and-anger-rumination-in-fibromyalgia-syndrome
#7
A Ricci, S Bonini, M Continanza, M T Turano, E M Puliti, A Finocchietti, D Bertolucci
The aim of the present study was twofold: 1) to investigate the psychological profile of patients with fibromyalgia syndrome (FS) as compared to patients with other chronic pain syndromes (CP) and healthy subjects (HS); 2) to examine the associations between anxiety, depression, worry and angry rumination in FS patients. FS patients (N=30), CP patients (N=30) and HS (N=30) completed measurements of anxiety, depression, worry and angry rumination. FS patients showed higher levels of state and trait anxiety, worry and angry rumination than CP patients and HS, and higher levels of depression than HS...
December 31, 2016: Reumatismo
https://www.readbyqxmd.com/read/28295784/health-related-quality-of-life-and-satisfaction-with-case-management-in-cancer-survivors
#8
Ya-Hui Hsu, Hsiu-Ying Chai, Yu-Fen Lin, Chao-Hui Wang, Shu-Ching Chen
AIMS AND OBJECTIVES: The purposes of this study were to (1) investigate the characteristics of health-related quality of life and satisfaction with case management, and (2) to identify factors associated with health-related quality of life in cancer survivors. BACKGROUND: The level of health-related quality of life can reflect treatment efficacy and satisfaction with cancer care. DESIGN: A cross-sectional study design was adopted. METHODS: Subjects from the outpatient setting of a cancer center in northern Taiwan were recruited by consecutive sampling...
March 15, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28293315/quality-of-life-in-patients-following-vertebroplasty
#9
Sasa Rapan, Jasna Batrnek, Vjeran Rapan, Egon Biuk, Domagoj Rapan
AIM: To examine the quality of life in patients who underwent vertebroplasty treatment and compare it to the preoperative quality of life. STUDY DESIGN: The Cross-sectional study conducted at the Department of Orthopaedics, Clinical Hospital Centre Osijek. PATIENTS AND METHODS: The research included 50 patients under stationary treatment in hospital at the Department of Orthopaedics. The research instruments include a questionnaire containing demographic data and the standardised EuroQuol Research Foundation Questionnaire (EQ-5D-5L) consisting of five dimensions which include mobility, self-care, usual activities, pain level and anxiety...
March 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28290813/-causes-of-angina-pectoris-in-survivors-of-myocardial-infarction-and-the-role-of-optimization-of-antianginal-therapy-data-of-the-linkor-study-e
#10
M G Glezer, E I Astashkin On Behalf Of The Linkor Study Investigators
AIM: to analyze causes of attacks of angina pectoris and assess impact of optimization of antianginal therapy on frequency of attacks provoked by various factors. MATERIAL AND METHOD: We analyzed diaries of 1226 survivors of myocardial infarction (MI) which occurred within 12months before inclusion in the LINKOR program. Causes of pain and their changes with correction of antianginal therapy were registered during 16 weeks of follow-up. RESULTS: Participants of the study indicated the following factors as causes of pain: physical exertion (74...
December 2016: Kardiologiia
https://www.readbyqxmd.com/read/28290469/longitudinal-employment-outcomes-of-an-early-intervention-vocational-rehabilitation-service-for-people-admitted-to-rehabilitation-with-a-traumatic-spinal-cord-injury
#11
G Hilton, C A Unsworth, G C Murphy, M Browne, J Olver
STUDY DESIGN: Longitudinal cohort design. OBJECTIVES: First, to explore the longitudinal outcomes for people who received early intervention vocational rehabilitation (EIVR); second, to examine the nature and extent of relationships between contextual factors and employment outcomes over time. SETTING: Both inpatient and community-based clients of a Spinal Community Integration Service (SCIS). METHODS: People of workforce age undergoing inpatient rehabilitation for traumatic spinal cord injury were invited to participate in EIVR as part of SCIS...
March 14, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28289782/neuro-psychopharmacological-perspective-of-orphan-receptors-of-rhodopsin-class-a-family-of-g-protein-coupled-receptors
#12
REVIEW
Muhammad Zahid Khan, Ling He
BACKGROUND: In the central nervous system (CNS), G protein-coupled receptors (GPCRs) are the most fruitful targets for neuropsychopharmacological drug development. Rhodopsin (class A) is the most studied class of GPCR and includes orphan receptors for which the endogenous ligand is not known or is unclear. Characterization of orphan GPCRs has proven to be challenging, and the production pace of GPCR-based drugs has been incredibly slow. OBJECTIVE: Determination of the functions of these receptors may provide unexpected insight into physiological and neuropathological processes...
March 13, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28288686/outcomes-of-dysvascular-partial-foot-amputation-and-how-these-compare-to-transtibial-amputation-a-systematic-review-for-the-development-of-shared-decision-making-resources
#13
Michael P Dillon, Matthew Quigley, Stefania Fatone
BACKGROUND: Dysvascular partial foot amputation (PFA) is a common sequel to advanced peripheral vascular disease. Helping inform difficult discussions between patients and practitioners about the level of PFA, or the decision to have a transtibial amputation (TTA) as an alternative, requires an understanding of the current research evidence on a wide range of topics including wound healing, reamputation, quality of life, mobility, functional ability, participation, pain and psychosocial outcomes, and mortality...
March 14, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28287907/relationship-between-types-of-exercise-and-quality-of-life-in-a-korean-metabolic-syndrome-population-a-cross-sectional-study
#14
Sang Ho Oh, Sun Han Son, Si Hyun Kang, Don-Kyu Kim, Kyung Mook Seo, Sang Yoon Lee
BACKGROUND: Metabolic syndrome (MetS) significantly correlates with exercise. MetS also has an independent and inverse correlation to quality of life (QoL). However, few studies have examined the association between exercise and QoL in people with MetS. The aim of this study was to ascertain the relationship between exercise and QoL in a MetS population. METHODS: This was a cross-sectional study using public data from the Sixth Korean National Health and Nutrition Examination Survey in 2014 (n = 7550)...
March 13, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28287775/musculoskeletal-complaints-anxiety-depression-symptoms-and-neuroticism-a-study-of-middle-aged-twins
#15
Olav Vassend, Espen Røysamb, Christopher Sivert Nielsen, Nikolai Olavi Czajkowski
BACKGROUND: Musculoskeletal (MS) complaints are reported commonly, but the extent to which such complaints reflect the severity of site-specific pathology or a more generalized susceptibility to feel pain/discomfort is uncertain. Both site-specific and more widespread MS conditions have been shown to be linked to anxiety and depression, but the nature of this relationship is poorly understood. In the present study the role of neuroticism as a shared risk factor that may possibly explain the co-occurrence between anxiety-depression and MS complaints was investigated...
March 13, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/28278329/patients-and-parents-needs-attitudes-and-perceptions-about-early-palliative-care-integration-in-pediatric-oncology
#16
Deena R Levine, Belinda N Mandrell, April Sykes, Michele Pritchard, Deborah Gibson, Heather J Symons, David Wendler, Justin N Baker
Importance: Early palliative care integration for cancer patients is now touted as the optimal care model, yet significant barriers often prevent its implementation. A perceived barrier, especially for pediatric oncology patients, is the notion that patients and their families may not need or want palliative care involvement early in the disease trajectory. Objective: To determine the perception of symptom burden early in treatment and assess attitudes toward early integration of palliative care in pediatric oncology patient-parent pairs...
March 9, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28278241/the-prevalence-of-diagnosed-chronic-conditions-and-multimorbidity-in-australia-a-method-for-estimating-population-prevalence-from-general-practice-patient-encounter-data
#17
Christopher Harrison, Joan Henderson, Graeme Miller, Helena Britt
OBJECTIVES: To estimate the prevalence of common chronic conditions and multimorbidity among patients at GP encounters and among people in the Australian population. To assess the extent to which use of each individual patient's GP attendance over the previous year, instead of the average for their age-sex group, affects the precision of national population prevalence estimates of diagnosed chronic conditions. DESIGN, SETTING AND PARTICIPANTS: A sub-study (between November 2012 and March 2016) of the Bettering the Evaluation and Care of Health program, a continuous national study of GP activity...
2017: PloS One
https://www.readbyqxmd.com/read/28276744/the-cohen-hoberman-inventory-of-physical-symptoms-factor-structure-and-preliminary-tests-of-reliability-and-validity-in-the-general-population
#18
Sarah F Allen, Mark A Wetherell, Michael A Smith
OBJECTIVE: The present study aimed to investigate the factor structure and psychometric properties of the Cohen-Hoberman inventory of physical symptoms (CHIPS). Construct and discriminant validity were examined by assessing associations between factors and subjective health complaints (SHC) inventory subscales in addition to measures of pain sensitivity, perceived stress and psychological distress. DESIGN: A cross-sectional online survey was conducted with 535 healthy individuals from the general population (80...
February 17, 2017: Psychology & Health
https://www.readbyqxmd.com/read/28274800/a-screening-tool-to-detect-clinical-manganese-neurotoxicity
#19
Brad A Racette, Anat Gross, Susan R Criswell, Harvey Checkoway, Susan Searles Nielsen
Manganese (Mn) over-exposure in occupational settings is associated with basal ganglia toxicity and a movement disorder characterized by parkinsonism (i.e., the signs and symptoms of Parkinson disease). A simple test to help non-neurologists identify workers with clinical Mn neurotoxicity represents an unmet need. In a cohort of Mn-exposed workers from welding worksites, with extensive clinical data, we developed a linear regression model to predict the Unified Parkinson Disease Rating Scale motor subsection part 3 (UPDRS3) score...
March 5, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28274697/pain-catastrophizing-and-negative-mood-states-following-spinal-cord-injury-transitioning-from-inpatient-rehabilitation-into-the-community
#20
Ashley Craig, Rebecca Guest, Yvonne Tran, Kathryn Nicholson Perry, James Middleton
Chronic pain is prevalent in people with spinal cord injury (SCI). This research investigated how chronic pain intensity and catastrophizing varies in adults with SCI during inpatient rehabilitation up to 12 months post-injury after transitioning into the community. Eighty-eight participants with SCI were assessed for pain intensity and catastrophizing, depressive mood states and cognitive performance. Participants were divided into sub-groups of clinically elevated depressive mood and anxiety versus those with normal mood state levels...
March 5, 2017: Journal of Pain: Official Journal of the American Pain Society
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