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Radiotherapy larynx

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https://www.readbyqxmd.com/read/28207586/open-partial-laryngectomy-after-failure-of-chemo-radiation-indications-oncologic-and-functional-outcomes
#1
Geoffrey Mortuaire, Dominique Chevalier, François Mouawad
PURPOSE OF REVIEW: Early-stage squamous cell carcinoma of the larynx can be successfully treated with radiotherapy or surgery (transoral or open approaches). Oncologic results are comparable while functional results may be different according to the volume of resection. In some countries radiotherapy is often preferred as primary treatment. In case of recurrence, surgical salvage is the only option. Careful examination, endoscopic assessment, computed tomography or magnetic resonance imaging are necessary to assess superficial and deep extensions into the larynx, including cartilage framework and to restage the tumor...
February 15, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/28206871/swallowing-therapy-and-progressive-resistance-training-in-head-and-neck-cancer-patients-undergoing-radiotherapy-treatment-randomized-control-trial-protocol-and-preliminary-data
#2
Sara F Hajdú, Irene Wessel, Christoffer Johansen, Claus A Kristensen, Zahra T Kadkhoda, Christina C Plaschke, Susanne O Dalton
BACKGROUND: Head and neck cancer (HNC) patients are often challenged by treatment induced dysphagia and trismus. Traditionally, rehabilitation is initiated when loss of function has already occurred. There is increasing evidence that it is of benefit to patients to initiate an early rehabilitation process before and during treatment. HNC patients have a unique set of functional challenges such as pre- and post-treatment dysphagia, pain and weight loss. The aim of the trial is to investigate the effects of swallowing and mouth-opening exercises combined with progressive resistance training (PRT) during radiotherapy...
February 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28182267/effect-of-postoperative-radiotherapy-on-survival-for-surgically-managed-pt3n0-and-pt4an0-laryngeal-cancer-analysis-of-the-national-cancer-data-base
#3
Evan M Graboyes, Kevin Y Zhan, Elizabeth Garrett-Mayer, Eric J Lentsch, Anand K Sharma, Terry A Day
BACKGROUND: The current study was conducted to determine the effect of postoperative radiotherapy (PORT) on overall survival in patients with surgically managed pT3-T4aN0 laryngeal squamous cell carcinoma (SCC). METHODS: A review of the National Cancer Data Base from 2004 through 2013 was performed. Patients with surgically managed pT3-4aN0 laryngeal SCC with negative surgical margins were included. Univariable and multivariable Cox regression analyses were used to determine factors associated with survival...
February 9, 2017: Cancer
https://www.readbyqxmd.com/read/28179586/phase-iii-randomized-trial-of-preoperative-concurrent-chemoradiotherapy-versus-preoperative-radiotherapy-for-patients-with-locally-advanced-head-and-neck-squamous-cell-carcinoma
#4
Junlin Yi, Xiaodong Huang, Zhengang Xu, Shaoyan Liu, Xiaolei Wang, Xiaohui He, Dehong Luo, Jingwei Luo, Jianping Xiao, Shiping Zhang, Kai Wang, Yuan Qu, Yuan Tang, Weixin Liu, Guozhen Xu, Li Gao, Dian Wang
PURPOSE: To determine the role of preoperative concurrent chemoradiotherapy in the treatment of locally advanced head and neck squamous cell carcinoma (HNSCC). METHODS: A total of 222 patients with stage III/IVA-B HNSCC were randomly assigned to receive preoperative concurrent chemoradiotherapy (Pre-S CRT, weekly cisplatin 30mg/m2) or preoperative radiotherapy alone (Pre-S RT). Survival analysis was estimated by the Kaplan-Meier method and compared by the log-rank test...
February 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28177326/supracricoid-laryngectomy-for-recurrent-laryngeal-cancer-after-chemoradiotherapy-a-systematic-review-and-meta-analysis
#5
C A Leone, P Capasso, D Topazio, G Russo
Residual or recurrent laryngeal cancer after irradiation is a difficult clinical problem with a rate that ranges from 13% to 36% of cases. Supracricoid laryngectomy (SCL) with cricohyoidopexy (CHP) or cricohyoidoepiglottopexy (CHEP) provide reliable oncological and functional results for selected primary and recurrent patients with glottic and supraglottic carcinomas. We conducted a systematic review and meta-analysis to assess the oncological and functional outcomes of patients treated with open partial horizontal laryngectomy types IIa and IIb (CHEP, CHP) in terms of the recurrence of squamocellular cancer of the larynx after radiotherapy failure...
December 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28047110/su-c-202-05-pilot-study-of-online-treatment-evaluation-and-adaptive-re-planning-for-laryngeal-sbrt
#6
W Mao, C Liu, H Zhong, T Rozario, W Lu, X Gu, Y Yan, X Jia, B Sumer, D Schwartz
PURPOSE: We have instigated a phase I trial of 5-fraction stereotactic body radiotherapy (SBRT) for advanced-stage laryngeal cancer. We conducted this pilot dosimetric study to confirm the potential utility of online adaptive re-planning to preserve treatment quality. METHODS: Ten cases of larynx cancer were evaluated. Baseline and daily SBRT treatment plans were generated per trial protocol. Daily volumetric images were acquired prior to every fraction of treatment...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046761/mo-g-201-01-a-multi-institutional-study-investigating-the-performance-of-a-knowledge-based-planning-system-against-pinnacle-auto-planning-engine-in-sib-imrt-for-the-head-and-neck-cancer
#7
B Wu, M Kusters, M Kunze-Busch, T Dijkema, T McNutt, G Sanguineti, D Pang
PURPOSE: Knowledge-based Planning (KBP) founded on prior planning experience and Auto-Planning Engine (APE; commercialized in Pinnacle v9.10 TPS) based on progressive optimization algorithm both aim to eliminate the trial-and-error process in radiotherapy inverse planning. This study investigates the performance of the approaches in a multi-institutional setting to evaluate their functionalities in oropharyngeal cancer and offers suggestions how they can be implemented in the clinic. METHODS: Radboud University Medical Center (RUMC) provided 35 oropharyngeal cancer patients (SIB-IMRT with two-dose-level prescription: 68 Gy to PTV68 and 50...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042407/nodular-fasciitis-of-the-neck-causing-emergency-a-case-report
#8
Serkan Yaşar Çelik, Yelda Dere, Özgür İlhan Çelik, Serhan Derin, Murat Şahan, Özcan Dere
Nodular fasciitis is a benign, reactive, tumor-like lesion composed of fibroblasts and myofibroblasts. It typically occurs in the extremities and the trunk. Head and neck localization is 13-20%. As it grows rapidly, clinicians frequently misdiagnose it as an aggressive or a malignant lesion. Some lesions show moderate cellularity, mild cellular atypia, and mitosis histologically causing pathologists to over-diagnose the lesion as a malignant tumor. It is important to diagnose nodular fasciitis correctly to avoid unnecessary additional surgery and treatment...
January 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28034705/real-life-efficacy-of-volumetric-modulated-arc-therapy-in-head-and-neck-squamous-cell-carcinoma
#9
C Moncharmont, A Vallard, J-B Guy, J-M Prades, C Rancoule, N Magné
OBJECTIVES: There is paucity of data on the efficacy of volumetric modulated arc therapy (VMAT) in head and neck squamous cell carcinoma (HNSCC). The objective of the present study was to investigate outcomes and patterns of recurrence in locally advanced HNSCC treated by VMAT. METHODS: A retrospective study included all patients with stage III or IV HNSCC undergoing curative VMAT. RESULTS: From 2010 to 2013, 130 patients were treated for locally advanced oropharynx (n=55; 42%), hypopharynx (n=38; 29%), larynx (n=22; 17%) or oral cavity (n=15; 12%) SCC...
December 26, 2016: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/28034680/implementation-of-intensity-modulated-radiotherapy-for-head-and-neck-cancers-in-routine-practice
#10
C Bednarek, T V F Nguyen, M Puyraveau, É Bonnet, N Lescut, C Azélie, J Miny, O Mauvais, T Maurina, F Tochet, J-F Bosset, J Thariat, X S Sun
PURPOSE: To report on patterns of relapse following implementation of intensity-modulated radiotherapy and subsequent changes in practice in a tertiary care centre. PATIENTS AND METHODS: Between 2008 and 2011, 188 consecutive patients (mean age 59 years old) received intensity-modulated radiotherapies with curative intent for squamous cell carcinomas of the oral cavity (17.5%), oropharynx (43%), hypopharynx (21%), larynx (14%), sinonasal cavities (6%), nasopharynx (1...
December 26, 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28033526/induction-chemotherapy%C3%A2-followed-by-radiotherapy-for-larynx-preservation-in-advanced-laryngeal-and-hypopharyngeal-cancer-outcome-prediction-after-one-cycle-induction-chemotherapy-by-a-score-based-on-clinical-evaluation-computed-tomography-based-volumetry%C3%A2-and
#11
Gunnar Wichmann, Anne Krüger, Andreas Boehm, Marlen Kolb, Mathias Hofer, Milos Fischer, Stefan Müller, Sandra Purz, Patrick Stumpp, Osama Sabri, Andreas Dietz, Regine Kluge
BACKGROUND: Long-term laryngectomy-free (LFS), tumour-specific (TSS) and overall survival (OS) is achieved by non-surgical larynx preservation (LP) only in a proportion of patients with locally advanced laryngeal or hypopharyngeal cancer. A score facilitating decision-making after 1 cycle induction chemotherapy (IC-1) may improve LFS and TSS. METHODS: Early response to IC-1 with TPF ± cetuximab was assessed in 52 patients using endoscopic tumour staging for selecting total laryngectomy for non-responders with endoscopic tumour surface shrinkage <30% versus induction chemotherapy plus radiotherapy (IC + RT) for responders...
December 26, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/28028607/transoral-laser-microsurgery-for-t1b-glottic-cancer-review-of-51-cases
#12
Bernhard G Weiss, Friedrich Ihler, Yiannis Pilavakis, Hendrik A Wolff, Martin Canis, Christian Welz, Wolfgang Steiner
For the treatment of T1b glottic carcinoma, different treatment options, such as transoral laser microsurgery, open surgical techniques, and primary radiotherapy, are under discussion. In this context, the aim of the present study was to describe oncologic results and complication rates of transoral laser microsurgery in treatment of T1b glottic carcinoma. This is a retrospective unicenter chart review of patients treated at an academic tertiary referral center between 1986 and 2006. Fifty-one previously untreated T1b cases were exclusively treated by transoral laser microsurgery and included into this study, 47 were male, and 4 were female...
December 27, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28024728/laryngeal-tumours-and-radiotherapy-dose-to-the-cricopharyngeus-are-predictive-of-death-from-aspiration-pneumonia
#13
Jolyne O'Hare, Julia Maclean, Michal Szczesniak, Rashmi Gupta, Peter Wu, Harry Quon, Ian Cook, Peter Graham
OBJECTIVES: Aspiration pneumonia is an under-reported treatment sequelae following radiotherapy for head and neck cancer (HNC) patients. This study aims to investigate its incidence and risk factors in this population. MATERIALS AND METHODS: A retrospective review of all HNC patients that had received radiotherapy or chemo radiotherapy with radical intent at a single institution was undertaken (n=206). Dose delivered to the pharyngeal constrictors, base of tongue and cricopharyngeus was calculated and compared between those patients who had died from aspiration pneumonia and those who are alive or had died from other causes...
January 2017: Oral Oncology
https://www.readbyqxmd.com/read/28001302/impact-of-concomitant-chemoradiation-on-survival-for-patients-with-t1-2n1-head-and-neck-cancer
#14
Zachary S Zumsteg, Sungjin Kim, John M David, Emi J Yoshida, Mourad Tighiouart, Stephen L Shiao, Kevin Scher, Alain Mita, Eric J Sherman, Nancy Y Lee, Allen S Ho
BACKGROUND: Single-modality radiotherapy is considered a standard-of-care option for certain stage III, T1-2N1 head and neck squamous cell carcinomas (HNSCCs). The role of concomitant chemoradiation is not well established because there have been no studies comparing chemoradiation with radiation alone in this population. METHODS: This study analyzed patients in the National Cancer Data Base with cT1-2N1M0 invasive squamous cell carcinomas of the oropharynx, larynx, and hypopharynx who were diagnosed between 2004 and 2012 and were undergoing definitive radiation...
December 21, 2016: Cancer
https://www.readbyqxmd.com/read/27929600/risk-of-thyroid-malignancy-following-an-index-head-and-neck-squamous-cell-carcinoma-a-population-based-study
#15
Jason Y Chan, Zhen Gooi, Wojciech K Mydlarz, Nishant Agrawal
To evaluate the incidence of a subsequent primary thyroid malignancy in patients with an index head and neck squamous cell carcinoma (HNSCC), we analyzed the National Cancer Institute's Surveillance, Epidemiology, and End Results database to identify a cohort of patients who had been diagnosed with a primary HNSCC from 1973 through 2004. The study population was made up of 60,323 patients of all ages, roughly three-quarters of whom were male. A total of 60 patients (0.1%) developed a subsequent thyroid malignancy-not a statistically significant finding...
December 2016: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/27922831/comprehensive-monte-carlo-study-of-patient-doses-from-cone-beam-ct-imaging-in-radiotherapy
#16
T E Marchant, K D Joshi
Accurate knowledge of ionizing radiation dose from cone-beam CT (CBCT) imaging in radiotherapy is important to allow concomitant risks to be estimated and for justification of imaging exposures. This study uses a Monte Carlo CBCT model to calculate imaging dose for a wide range of imaging protocols for male and female patients. The Elekta XVI CBCT system was modeled using GATE and simulated doses were validated against measurements in a water tank and thorax phantom. Imaging dose was simulated in the male and female ICRP voxel phantoms for a variety of anatomical sites and imager settings (different collimators, filters, full and partial rotation)...
December 6, 2016: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/27888508/outcomes-following-laryngectomy-refusal-after-insufficient-response-to-induction-chemotherapy
#17
Philippe Gorphe, Margarida Matias, Pierre Blanchard, Caroline Even, Charles Ferte, Yungan Tao, Stéphane Temam, François Bidault, François Janot
OBJECTIVE: To review patients who refused a total laryngectomy and were treated with radiotherapy (RT) after insufficient response to induction chemotherapy in a larynx preservation protocol for advanced-stage cancer of the larynx and to compare their outcomes with good responders. STUDY DESIGN: Retrospective cohort study. METHODS: Eighty-six patients treated with induction chemotherapy followed by RT were included in the analysis: 75 good responders and 11 insufficient responders who refused surgery...
November 26, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27871805/the-survival-rate-and-larynx-preservation-in-elderly-cancer-patients-who-received-surgical-operation-a-retrospective-cohort-study
#18
Qin Wang, Yehai Liu, Guoqin Hu, Ruokun Wang, Yi Zhao, Ming Zhang
BACKGROUND: To investigate the efficiency of surgical operation for patients over 70 years with hypopharyngeal cancer. MATERIALS AND METHODS: A retrospective analysis of the medical records from 68 patients over 70 years-old with hypopharyngeal cancer who underwent different therapeutic regimen between 2000 and 2009 was conducted. 36 of 68 patients underwent larynx preservation. All patients were treated with surgical operation and adjuvant radiotherapy. A Kaplan-Meier method was employed to calculate the survival rate...
December 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27846899/contribution-of-submandibular-gland-and-swallowing-structure-sparing-to-post-radiation-therapy-peg-dependence-in-oropharynx-cancer-patients-treated-with-split-neck-imrt-technique
#19
Michael F Gensheimer, Matthew Nyflot, George E Laramore, Jay J Liao, Upendra Parvathaneni
BACKGROUND: Radiation therapy-related dysphagia is worsened by xerostomia. The submandibular glands (SMG) produce saliva rich in lubricating mucins, and sparing the SMG has been shown to reduce xerostomia. The goal of this study was to determine whether SMG sparing IMRT is associated with reduced post-treatment PEG dependence in locally advanced oropharynx cancer patients. METHODS: Patients treated with definitive radiation therapy for oropharynx cancer were included in this retrospective study...
November 15, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27843342/the-danish-head-and-neck-cancer-database
#20
REVIEW
Jens Overgaard, Aleksandar Jovanovic, Christian Godballe, Jesper Grau Eriksen
AIM OF THE DATABASE: The Danish Head and Neck Cancer database is a nationwide clinical quality database that contains prospective data collected since the early 1960s. The overall aim of this study was to describe the outcome of the national strategy for multidisciplinary treatment of head and neck cancer in Denmark and to create a basis for clinical trials. STUDY POPULATION: The study population consisted of all Danish patients referred for treatment of squamous cell carcinoma of the larynx, pharynx, oral cavity, or neck nodes from unknown primary or any histopathological type (except lymphoma) of cancer in the nasal sinuses, salivary glands, or thyroid gland (corresponding to the International Classification of Diseases, tenth revision, classifications C...
2016: Clinical Epidemiology
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