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Radiotherapy larynx

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https://www.readbyqxmd.com/read/27888508/outcomes-following-laryngectomy-refusal-after-insufficient-response-to-induction-chemotherapy
#1
Philippe Gorphe, Margarida Matias, Pierre Blanchard, Caroline Even, Charles Ferte, Yungan Tao, Stéphane Temam, François Bidault, François Janot
OBJECTIVE: To review patients who refused a total laryngectomy and were treated with radiotherapy (RT) after insufficient response to induction chemotherapy in a larynx preservation protocol for advanced-stage cancer of the larynx and to compare their outcomes with good responders. STUDY DESIGN: Retrospective cohort study. METHODS: Eighty-six patients treated with induction chemotherapy followed by RT were included in the analysis: 75 good responders and 11 insufficient responders who refused surgery...
November 26, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27871805/the-survival-rate-and-larynx-preservation-in-elderly-cancer-patients-who-received-surgical-operation-a-retrospective-cohort-study
#2
Qin Wang, Yehai Liu, Guoqin Hu, Ruokun Wang, Yi Zhao, Ming Zhang
BACKGROUND: To investigate the efficiency of surgical operation for patients over 70 years with hypopharyngeal cancer. MATERIALS AND METHODS: A retrospective analysis of the medical records from 68 patients over 70 years-old with hypopharyngeal cancer who underwent different therapeutic regimen between 2000 and 2009 was conducted. 36 of 68 patients underwent larynx preservation. All patients were treated with surgical operation and adjuvant radiotherapy. A Kaplan-Meier method was employed to calculate the survival rate...
November 15, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27846899/contribution-of-submandibular-gland-and-swallowing-structure-sparing-to-post-radiation-therapy-peg-dependence-in-oropharynx-cancer-patients-treated-with-split-neck-imrt-technique
#3
Michael F Gensheimer, Matthew Nyflot, George E Laramore, Jay J Liao, Upendra Parvathaneni
BACKGROUND: Radiation therapy-related dysphagia is worsened by xerostomia. The submandibular glands (SMG) produce saliva rich in lubricating mucins, and sparing the SMG has been shown to reduce xerostomia. The goal of this study was to determine whether SMG sparing IMRT is associated with reduced post-treatment PEG dependence in locally advanced oropharynx cancer patients. METHODS: Patients treated with definitive radiation therapy for oropharynx cancer were included in this retrospective study...
November 15, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27843342/the-danish-head-and-neck-cancer-database
#4
REVIEW
Jens Overgaard, Aleksandar Jovanovic, Christian Godballe, Jesper Grau Eriksen
AIM OF THE DATABASE: The Danish Head and Neck Cancer database is a nationwide clinical quality database that contains prospective data collected since the early 1960s. The overall aim of this study was to describe the outcome of the national strategy for multidisciplinary treatment of head and neck cancer in Denmark and to create a basis for clinical trials. STUDY POPULATION: The study population consisted of all Danish patients referred for treatment of squamous cell carcinoma of the larynx, pharynx, oral cavity, or neck nodes from unknown primary or any histopathological type (except lymphoma) of cancer in the nasal sinuses, salivary glands, or thyroid gland (corresponding to the International Classification of Diseases, tenth revision, classifications C...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27825651/sequential-four-drug-chemotherapy-and-intensity-modulated-radiotherapy-for-larynx-preservation-in-resectable-advanced-larynx-and-hypopharynx-cancer-a-pilot-study
#5
Xuan Su, Caiyun He, Tao Tang, Weichao Chen, Zhaoqu Li, Yong Chen, Ankui Yang
OBJECTIVE: The value of additional use of cetuximab with the classical cisplatin, docetaxel and 5-fluorouracil regimen in larynx preservation remains unknown. This study was designed to resolve this issue and appraise its toxicity. MATERIALS AND METHODS: Thirteen untreated patients with stage III-IV larynx or hypopharynx squamous cell carcinoma were recruited and received two cycles of C+TPF regimen (cetuximab plus docetaxel, cisplatinand and 5-fluorouracil), followed by one more cycle of C+TPF and intensity-modulated radiotherapy (70Gy)...
September 28, 2016: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/27812692/radiotherapy-characteristics-and-outcomes-for-head-and-neck-carcinoma-of-unknown-primary-vs-t1-base-of-tongue-carcinoma
#6
Ali Hosni, Peter R Dixon, Anupam Rishi, Michael Au, Wei Xu, Yuyao Song, Douglas B Chepeha, David P Goldstein, Shao Hui Huang, John Kim, Brian O'Sullivan, John Waldron, Scott V Bratman, John R de Almeida
Importance: Transoral robotic surgery- or transoral laser microsurgery-assisted lingual tonsillectomy may improve the identification rate of hidden base-of-tongue (BOT) carcinoma presenting as head or neck carcinoma of unknown primary (CUP) site. Objective: To evaluate the potential impact of lingual tonsillectomy in CUP site by comparing differences in radiotherapy volumes, dosimetry, and clinical outcomes for CUP site and T1-category BOT carcinoma. Design, Setting, and Participants: Retrospective study of 115 patients treated at a tertiary cancer center between January 1, 2005, and December 31, 2013, that included patients with BOT carcinoma (category T1N1-3M0) and CUP site (category T0N1-3M0) with known p16 status...
November 3, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27802182/dynamic-contrast-enhanced-magnetic-resonance-imaging-for-pretreatment-prediction-of-early-chemo-radiotherapy-response-in-larynx-and-hypopharynx-carcinoma
#7
Wei Guo, Dehong Luo, Xinyi Chen, Meng Lin, Lin Li, Yanfeng Zhao, Liang Yang, Lei Hu, Xinming Zhao, Chunwu Zhou
PURPOSE: This study is to investigate the use of dynamic contrast-enhanced magnetic resonance imaging in predicting early response to CRT (chemo-radiotherapy) in patients with larynx and hypopharynx carcinoma from primary tumors. METHOD: Sixty-two patients with larynx and hypopharynx carcinoma underwent two DCE-MRI studies: a baseline exam before any treatmentanda post-treatment exam 3 weeks after CRT. At the end of treatment, patients were classified as responders, or non-responders according to the Response Evaluation Criteria in Solid Tumors criteria (RECIST)...
October 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/27790562/toxicity-profile-of-imrt-vs-3d-crt-in-head-and-neck-cancer-a-retrospective-study
#8
Gopa Ghosh, Ramanjis Tallari, Anupam Malviya
INTRODUCTION: Role of radiotherapy in comprehensive management of head and neck cancer for achieving tumour control and organ preservation is now well established and radiotherapy is routinely used in adjuvant setting after surgery, concurrently with chemotherapy or targeted agents and for palliation. Development of linear accelerator with Multileaf Collimator (MLC) have revolutionized radiation delivery techniques, allowing conformal and Intensity Modulated Radiotherapy (IMRT) to deliver highly conformal sculpted radiation dose to a very complex structure with improved sparing of adjoining critical structures like salivary glands, spinal cord, eyes, brainstem and larynx amounting to better therapeutic gain...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27789194/carotid-blowout-syndrome-in-patients-treated-by-larynx-cancer
#9
Carlos Miguel Chiesa Estomba, Frank Alberto Betances Reinoso, Alejandra Osorio Velasquez, Olalla Castro Macia, Maria Jesus Gonzalez Cortés, Jesus Araujo Nores
INTRODUCTION: Carotid blowout syndrome is an uncommon complication for patient treated by head and neck tumours, related with a high mortality rate. OBJECTIVE: The aim of this study was to study the risk of carotid blowout in a large cohort of patients treated only by larynx cancer. METHODS: Retrospective analysis of patients older than 18 years, treated by larynx cancer who developed a carotid blowout syndrome in a tertiary academic centre...
September 29, 2016: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/27734981/malignant-salivary-gland-tumours-of-the-larynx-a-single-institution-review
#10
S Karatayli-Ozgursoy, J A Bishop, A T Hillel, L M Akst, S R Best
Malignant salivary gland tumours of the larynx are very rare, with limited reports of clinical outcomes. We present the decade-long experience of a single institution. A 10-year retrospective chart review of a tertiary head and neck cancer centre was performed. Index patients were identified from a review of a pathology database, and reviewed by a head and neck pathologist. Patient demographics, presenting signs and symptoms, treatment modalities and clinical outcomes were extracted from electronic medical records...
August 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27733374/phase-ii-trial-of-post-operative-radiotherapy-with-concurrent-cisplatin-plus-panitumumab-in-patients-with-high-risk-resected-head-and-neck-cancer
#11
R L Ferris, J L Geiger, S Trivedi, N C Schmitt, D E Heron, J T Johnson, S Kim, U Duvvuri, D A Clump, J E Bauman, J P Ohr, W E Gooding, A Argiris
BACKGROUND: Treatment intensification for resected, high-risk, head and neck squamous cell carcinoma (HNSCC) is an area of active investigation with novel adjuvant regimens under study. In this trial, the epidermal growth-factor receptor (EGFR) pathway was targeted using the IgG2 monoclonal antibody panitumumab in combination with cisplatin chemoradiotherapy (CRT) in high-risk, resected HNSCC. PATIENTS AND METHODS: Eligible patients included resected pathologic stage III or IVA squamous cell carcinoma of the oral cavity, larynx, hypopharynx, or human-papillomavirus (HPV)-negative oropharynx, without gross residual tumor, featuring high-risk factors (margins <1 mm, extracapsular extension, perineural or angiolymphatic invasion, or ≥2 positive lymph nodes)...
October 11, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27730326/radiotherapy-for-elderly-patients-and-cetuximab-a-monocentric-study
#12
Alexander T Falk, Christophe Hébert, Antoine Tran, Marie-Eve Chand, Axel Leysalle, Juliette Thariat, Olivier Dassonville, Gilles Poissonnet, Alexandre Bozec, Esma Saada, Fréderic Peyrade, Karen Benezery
Concomitant radiotherapy and cetuximab association has shown superiority to exclusive radiotherapy for head and neck cancers. Data on this association are scarce for the elderly population despite its rising incidence. A retrospective monocentric data collection was performed in the Antoine Lacassagne Cancer Center in France. Inclusion criteria were: age >70 years at time of diagnosis, histologically proven head and neck epidermoid carcinoma, treated with radiotherapy combined with cetuximab. Thirty-five patients were included between 2008 and 2012...
October 11, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27727461/a-comparison-of-overall-survival-for-patients-with-t4-larynx-cancer-treated-with-surgical-versus-organ-preservation-approaches-a-national-cancer-data-base-analysis
#13
William A Stokes, Bernard L Jones, Shilpa Bhatia, Ayman J Oweida, Daniel W Bowles, David Raben, Julie A Goddard, Jessica D McDermott, Sana D Karam
BACKGROUND: Although laryngectomy is the treatment of choice for patients with T4 larynx cancer, many patients are unable or unwilling to undergo laryngectomy and instead pursue larynx-preservation strategies combining radiotherapy (RT) and chemotherapy. Herein, the authors analyzed the National Cancer Data Base to evaluate overall survival (OS) between patients treated with surgical and organ-preserving modalities. METHODS: The National Cancer Data Base was queried for patients diagnosed from 2004 through 2012 with T4M0 laryngeal cancer who underwent either laryngectomy (surgery) with adjuvant RT (SRT), chemotherapy starting concurrently within 7 days of RT (CCRT), or multiagent induction chemotherapy starting 43 to 98 days before RT (ICRT)...
October 11, 2016: Cancer
https://www.readbyqxmd.com/read/27721662/a-novel-digital-patient-reported-outcome-platform-for-head-and-neck-oncology-patients-a-pilot-study
#14
Maria K Peltola, Joel S Lehikoinen, Lauri T Sippola, Kauko Saarilahti, Antti A Mäkitie
INTRODUCTION: The patient's role in toxicity reporting is increasingly acknowledged. There is also a need for developing modern communication methods between the patient and the medical personnel. Furthermore, the increasing number of head and neck cancer (HNC) patients is reflected in the volume of treatment follow-up visits, which remains a challenge for the health care. Electronic patient-reported outcome (ePRO) measures may provide a cost-efficient way to organize follow-up for cancer patients...
2016: Clinical Medicine Insights. Ear, Nose and Throat
https://www.readbyqxmd.com/read/27716125/dars-a-phase-iii-randomised-multicentre-study-of-dysphagia-optimised-intensity-modulated-radiotherapy-do-imrt-versus-standard-intensity-modulated-radiotherapy-s-imrt-in-head-and-neck-cancer
#15
Imran Petkar, Keith Rooney, Justin W G Roe, Joanne M Patterson, David Bernstein, Justine M Tyler, Marie A Emson, James P Morden, Kathrin Mertens, Elizabeth Miles, Matthew Beasley, Tom Roques, Shreerang A Bhide, Kate L Newbold, Kevin J Harrington, Emma Hall, Christopher M Nutting
BACKGROUND: Persistent dysphagia following primary chemoradiation (CRT) for head and neck cancers can have a devastating impact on patients' quality of life. Single arm studies have shown that the dosimetric sparing of critical swallowing structures such as the pharyngeal constrictor muscle and supraglottic larynx can translate to better functional outcomes. However, there are no current randomised studies to confirm the benefits of such swallow sparing strategies. The aim of Dysphagia/Aspiration at risk structures (DARS) trial is to determine whether reducing the dose to the pharyngeal constrictors with dysphagia-optimised intensity- modulated radiotherapy (Do-IMRT) will lead to an improvement in long- term swallowing function without having any detrimental impact on disease-specific survival outcomes...
October 6, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27699075/pleomorphic-rhabdomyosarcoma-arising-from-true-vocal-fold-of-larynx-report-of-a-rare-case-and-literature-review
#16
Sevdegül Mungan, Selçuk Arslan, Eda Küçüktülü, Şafak Ersöz, Bengü Çobanoğlu
We present an extremely rare case of a pleomorphic rhabdomyosarcoma of the true vocal fold. The histopathological diagnosis was confirmed by immunohistochemistry. The patient was treated with radical surgery including total laryngectomy and radical neck dissection followed by postoperative radiotherapy. The clinicopathologic features of this rare malignancy are discussed together with a review of the literature. This case report and literature review highlights the more favorable prognosis of pleomorphic rhabdomyosarcoma in the larynx than in other locations...
2016: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/27698593/hypofractionated-accelerated-radiotherapy-in-t1-3-n0-cancer-of-the-larynx-a-prospective-cohort-study-with-historical-controls
#17
Zbigniew Szutkowski, Andrzej Kawecki, Andrzej Jarząbski, Zofia Laskus, Romuald Krajewski, Wojciech Michalski, Paweł Kukołowicz
AIM: The goal of this prospective study was to assess the effectiveness of a hypofractionated accelerated regime in treatment of the larynx cancer. BACKGROUND: Multiple radiotherapy delivery regimes are used for treatment of the larynx cancer. Hypofractionated regimes could provide similar results with reduced use of radiotherapy facilities. MATERIAL AND METHODS: 223 patients with squamous cell carcinoma of the upper or middle larynx have been treated with 63 Gy delivered in 28 fractions of 2...
November 2016: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/27688116/prospective-swallowing-outcomes-after-imrt-for-oropharyngeal-cancer-dosimetric-correlations-in-a-population-based-cohort
#18
Gordon Z Guo, Keith R Sutherland, Candace Myers, Pascal Lambert, Shaun K Loewen, Harvey C Quon
OBJECTIVES: To identify dose constraints to preserve swallowing after head and neck (H&N) radiotherapy using prospectively collected functional outcomes. MATERIALS AND METHODS: Stage III-IV oropharyngeal cancer patients were prospectively evaluated using the Royal Brisbane Hospital Outcome Measure for Swallowing and Performance Status Scale for H&N Cancer Patients at pre-treatment and 3, 6, 12, and 24months after intensity-modulated radiotherapy. Dosimetric parameters were correlated with swallowing function...
October 2016: Oral Oncology
https://www.readbyqxmd.com/read/27666718/-advances-of-the-treatments-for-thyroid-carcinoma-patients-with-laryngotracheal-invasion
#19
L Y Li, H L Yi
Thyroid carcinoma is one of the most common cancer in the head and neck and its incidence shows an increasing tendency. Due to the special anatomical location of thyroid carcinoma, patients will have a bad prognosis outcome when cancer invades larynx and trachea. Surgical treatment is still a preferred therapy for thyroid carcinoma with laryngotracheal invasion, because it has the advantages such as high survival rate, low recurrence rate, relieving of airway obstruction, improving of postoperative quality of life...
September 7, 2016: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/27666333/fungal-contribution-in-chondroradionecrosis-of-the-larynx
#20
Mary Worthen, Mia Jusufbegovic, Jeffrey M Bumpous, Andrew Vaughn, Elizabeth Cash, Xiu Yang, Craig Fichandler, Paul Tennant
OBJECTIVE: To assess the prevalence of invasive fungal elements in the specimens of patients who underwent salvage total laryngectomy for chondroradionecrosis (CRN) in the absence of recurrent or persistent malignancy. STUDY DESIGN: Retrospective chart review. SETTING: Tertiary academic medical center. METHODS: One hundred fifty-nine patients were identified who underwent salvage total laryngectomy. Pathology reports were reviewed, and all laryngectomy specimens that did not contain residual malignancy were reevaluated for evidence of invasive fungal elements...
September 26, 2016: Laryngoscope
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