keyword
MENU ▼
Read by QxMD icon Read
search

IgG4 mediated renal diseases

keyword
https://www.readbyqxmd.com/read/27890680/the-putative-role-of-maldi-msi-in-the-study-of-membranous-nephropathy
#1
Andrew Smith, Vincenzo L'Imperio, Elena Ajello, Franco Ferrario, Niccolò Mosele, Martina Stella, Manuel Galli, Clizia Chinello, Federico Pieruzzi, Goce Spasovski, Fabio Pagni, Fulvio Magni
Membranous Nephropathy (MN) is an immunocomplex mediated renal disease that represents the leading cause of nephrotic syndrome in adults and is one of the most frequent glomerulopathies worldwide. This glomerular disease can manifest as primary (idiopathic) or secondary and this distinction is crucial when choosing the most appropriate management of patients. In secondary cases, the best strategy consists in treating the underlying disease whereas in primary forms, the possible identification of confirmatory markers of the idiopathic etiology underlining the process is requested by clinicians...
November 23, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27390645/igg4-related-disease-a-case-report-with-duration-of-more-than-16%C3%A2-years-and-review-of-literature
#2
Tao Peng, Zhao Hu, Tingting Xie, Baodong Jiang, Junhui Zhen, Xiangdong Yang
INTRODUCTION: IgG4-related disease was first reported in 2001 and was officially named in 2010. It is now considered as a systemic disease that might affect any organ system. The characteristic pathological changes of IgG4-related disease are extensive infiltration of IgG4-positive plasma cells. IgG4-related disease is a kind of benign lesions, but there has not been well-defined standard treatment so far. Patients usually respond well to corticosteroids. The prognosis of IgG4-related disease is perhaps good as long as early detection and treatment...
2016: SpringerPlus
https://www.readbyqxmd.com/read/26860343/idiopathic-retroperitoneal-fibrosis
#3
Augusto Vaglio, Federica Maritati
Idiopathic retroperitoneal fibrosis (RPF), reviewed herein, is a rare fibro-inflammatory disease that develops around the abdominal aorta and the iliac arteries, and spreads into the adjacent retroperitoneum, where it frequently causes ureteral obstruction and renal failure. The clinical phenotype of RPF is complex, because it can be associated with fibro-inflammatory disorders involving other organs, is considered part of the spectrum of IgG4-related disease, and often arises in patients with other autoimmune conditions...
July 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/26122730/igg4-related-disease-and-the-kidney
#4
REVIEW
Frank B Cortazar, John H Stone
IgG4-related disease (IgG4-RD) is a systemic fibroinflammatory condition that involves almost every organ system. In this Review, we summarize current knowledge of IgG4-RD and its most frequent manifestations in the kidney—IgG4-related tubulointerstitial nephritis (TIN) and membranous glomerulonephropathy (MGN). Diagnosis of IgG4-RD relies on histopathology: the typical features are a dense lymphoplasmacytic infiltrate and storiform fibrosis. A high percentage of plasma cells observed within lesions stain positively for IgG4...
October 2015: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/26060366/membranous-nephropathy-as-a-rare-renal-manifestation-of-igg4-related-disease
#5
A A Kurien, A Raychaudhury, P D Walker
IgG4-related disease, a newly described immune-mediated disorder with tissue infiltration of IgG4-positive plasma cells, has been reported in nearly every organ. In the kidney, it manifests as IgG4-related tubulointerstitial nephritis (TIN) but may also present as membranous nephropathy. We report a patient with IgG4 renal disease who had membranous nephropathy as well as TIN.
May 2015: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/24879326/intraorbital-injection-of-rituximab-in-idiopathic-orbital-inflammatory-syndrome-case-reports
#6
Gustavo Savino, Remo Battendieri, Andrea Siniscalco, Erika Mandarà, Antonino Mulè, Gianluigi Petrone, Salvatore Traina, Monica Riso
To analyze the clinical and histopathological effects of low doses of intraorbital and intralesional Rituximab (RTX) in three patients affected by idiopathic orbital inflammatory syndrome (IOIS). Three patients with IOIS were enrolled, all of whom underwent lesion biopsy to confirm the diagnosis, complete blood examinations (thyroid function tests, complete blood cell count, fasting blood glucose, liver and renal function tests, erythrocyte sedimentation rate, serum ACE, C-reactive protein, rheumatoid factor, antinuclear antibody, antineutrophil cytoplasmic antibody, serum IGg4 level tests) and magnetic resonance imaging (MRI)...
January 2015: Rheumatology International
https://www.readbyqxmd.com/read/23857085/clinical-features-of-10-patients-with-igg4-related-retroperitoneal-fibrosis
#7
REVIEW
Kazuro Chiba, Terumi Kamisawa, Taku Tabata, Seiichi Hara, Sawako Kuruma, Takashi Fujiwara, Go Kuwata, Hideto Egashira, Koichi Koizumi, Satomi Koizumi, Junko Fujiwara, Takeo Arakawa, Kumiko Momma, Keigo Setoguchi, Mitsuru Shinohara
OBJECTIVE: To elucidate the clinical characteristics of IgG4-related retroperitoneal fibrosis (RF). METHODS: IgG4-related RF was diagnosed when all of the following three criteria were fulfilled: retroperitoneal soft tissue masses surrounding the aorta and/or adjacent tissues, elevation of the serum IgG4 levels, and abundant infiltration of IgG4-positive plasma cells in at least one organ or site. Ten patients were diagnosed as having IgG4-related RF. RESULTS: The mean age at diagnosis was 70...
2013: Internal Medicine
https://www.readbyqxmd.com/read/23254897/membranous-glomerulonephritis-is-a-manifestation-of-igg4-related-disease
#8
Mariam P Alexander, Christopher P Larsen, Ian W Gibson, Samih H Nasr, Sanjeev Sethi, Mary E Fidler, Yassaman Raissian, Naoki Takahashi, Suresh Chari, Thomas C Smyrk, Lynn D Cornell
IgG4-related disease (IgG4-RD) is a systemic immune-mediated disease that typically manifests as fibro-inflammatory masses that can affect nearly any organ system. Renal involvement by IgG4-RD usually takes the form of IgG4-related tubulointerstitial nephritis, but cases of membranous glomerulonephritis (MGN) have also been described. Here we present a series of 9 patients (mean age at diagnosis 58 years) with MGN associated with IgG4-RD. All patients showed MGN on biopsy, presented with proteinuria (mean 8...
March 2013: Kidney International
https://www.readbyqxmd.com/read/23068304/igg4-related-kidney-disease
#9
REVIEW
Lynn D Cornell
IgG4-related kidney disease is a term that refers to any form of renal involvement by IgG4-related disease (IgG4-RD), a recently recognized systemic immune-mediated disease. The most common renal manifestation is IgG4-related tubulointerstitial nephritis (IgG4-TIN), which presents as acute or chronic renal insufficiency, renal mass lesions, or both. On biopsy, IgG4-TIN shows a plasma cell-rich interstitial inflammatory infiltrate with increased IgG4+ plasma cells, along with expansile interstitial fibrosis; tubular basement membrane immune complex deposits are common...
November 2012: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/22677550/pathology-after-eculizumab-in-dense-deposit-disease-and-c3-gn
#10
Leal C Herlitz, Andrew S Bomback, Glen S Markowitz, M Barry Stokes, R Neal Smith, Robert B Colvin, Gerald B Appel, Vivette D D'Agati
Eculizumab might benefit C3 glomerulopathies mediated by dysregulation of the alternative complement pathway. Here, we report renal biopsy findings before and after eculizumab therapy in three patients with dense deposit disease and two with C3 GN. All pretreatment biopsies had glomerular and tubular basement membrane deposits that stained exclusively for C3 without significant Ig. After 1 year of therapy, there was reduction in active glomerular proliferation and neutrophil infiltration in three of five patients, consistent with effective C5 blockade, which prevents production of chemotactin C5a...
July 2012: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/21896524/the-many-faces-of-merlin-igg4-associated-pulmonary-renal-disease
#11
Ben Sprangers, Pieter Lioen, Björn Meijers, Evelyne Lerut, Joke Meersschaert, Daniel Blockmans, Kathleen Claes
Pulmonary-renal syndrome is a common and serious disorder with a broad differential diagnosis. We describe a case of a middle-aged man presenting with interstitial pulmonary disease and severe renal impairment caused by a hypocomplementemic immune-complex-mediated interstitial nephritis. Serum levels of IgG4 were elevated, and renal biopsy specimens revealed the presence of interstitial IgG4(+) plasma cells. There was a rapid improvement of both pulmonary and renal abnormalities after the initiation of corticosteroids...
September 2011: Chest
https://www.readbyqxmd.com/read/21166697/deposition-of-complement-c3c-immunoglobulin-ig-g4-and-igg-at-the-basement-membrane-of-pancreatic-ducts-and-acini-in-autoimmune-pancreatitis
#12
Sönke Detlefsen, Jan Hinrich Bräsen, Giuseppe Zamboni, Paola Capelli, Günter Klöppel
AIMS: Autoimmune pancreatitis (AIP) is a type of pancreatitis whose immunopathogenesis is still unknown. It has been reported that renal biopsy specimens from patients diagnosed with both AIP and tubulointerstitial nephritis reveal deposits containing complement C3, immunoglobulin (Ig)G and IgG4 at the tubular basement membranes (BMs). The aim was to investigate the deposition of complement and immunoglobulins in pancreatic tissue from AIP patients compared to non-AIP patients. METHODS: Double immunofluorescence microscopy for C3c, IgG4 and IgG together with CK7, trypsin, collagen IV, CD31 and CD79a, as well as immunofluorescence microscopy for C1q, IgA and IgM, were performed on frozen pancreatic tissue from AIP and alcoholic chronic pancreatitis (ACP) patients...
December 2010: Histopathology
https://www.readbyqxmd.com/read/21124080/chronic-periaortitis-a-large-vessel-vasculitis
#13
REVIEW
Augusto Vaglio, Nicolò Pipitone, Carlo Salvarani
PURPOSE OF REVIEW: Chronic periaortitis is characterized by a fibro-inflammatory process spreading from the abdominal aorta and the iliac arteries. Originally, chronic periaortitis was considered a localized inflammatory response to severe aortic atherosclerosis. However, subsequent studies have shown that chronic periaortitis may also involve other arteries and present with features of auto-immune diseases. This article reviews the issue of large-vessel involvement in chronic periaortitis and its implications in the pathogenesis and nosography of the disease...
January 2011: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/19715171/-anti-musk-antibody-positive-myasthenia-gravis-with-nephrotic-syndrome-a-case-report
#14
Mitsuaki Shioyama, Haruo Ueda, Hiromi Aomatsu, Yoshiyuki Mitui, Yoshito Naiki, Kenichi Samejima, Masanori Funauchi, Hirokazu Shiraishi, Masakatsu Motomura, Susumu Kusunoki
A 40-year-old man was admitted to our hospital because of dysarthria, difficulty swallowing, double vision and weakness of both upper extremities. There were no detectable anti-AChR antibodies. He was diagnosed with seronegative myasthenia gravis (SNMG) based on a positive edrophonium test and positive waning on repetitive stimulation. Thereafter serological examination detected anti-muscle-specific kinase (MuSK) antibodies and he was diagnosed with anti-MuSK antibody-positive MG. Three years after the onset, the patient developed rapidly progressing respiratory failure and fever...
July 2009: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/17122509/autoimmune-pancreatitis-a-systemic-immune-complex-mediated-disease
#15
Vikram Deshpande, Sonia Chicano, Sonia Chiocca, Dmitry Finkelberg, Martin K Selig, Mari Mino-Kenudson, William R Brugge, Robert B Colvin, Gregory Y Lauwers
Autoimmune pancreatitis (AIP) is a mass forming inflammatory pancreatobiliary-centric disease. Recent reports of multiorgan inflammatory mass forming lesions with increased numbers of IgG4 positive plasma cells suggest that AIP may have a systemic component. In this study, we explore the systemic nature of AIP, investigate the relevance of subtyping AIP, perform a systematic study of tissue IgG4 immunoperoxidase, and ultrastructurally evaluate the presence of immune complexes. Our study group consisted of 36 patients with AIP, 21 of whom underwent a Whipple procedure...
December 2006: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/16871390/polyclonal-igg4-hypergammaglobulinemia-associated-with-plasmacytic-lymphadenopathy-anemia-and-nephropathy
#16
Emmanuelle Boulanger, Vincent Fuentes, Véronique Meignin, Béatrice Mougenot, Sylvaine Labaume, Valérie Gouilleux-Gruart, Michel Cogné, Pierre Aucouturier, Jean-Pierre Clauvel, Pierre Ronco, Kaiss Lassoued
Marked polyclonal immunoglobulin (Ig)G4 hypergammaglobulinemia has exceptionally been reported. Here we report on two Algerian patients who presented a syndrome characterized by anemia, plasmacytic lymphadenopathy, renal manifestations, and a marked polyclonal IgG4 hypergammaglobulinemia leading to a hyperviscosity syndrome in one case. The IgG4-expressing cell percentage was significantly increased in the peripheral blood lymphocytes collected from the two patients upon diagnosis. Moreover, in contrast with normal sera, both patients' sera significantly increased the percentage of IgG4-expressing cells when incubated with CD40-stimulated normal B lymphocytes...
December 2006: Annals of Hematology
https://www.readbyqxmd.com/read/7670945/renal-and-systemic-transvascular-albumin-leakage-in-severe-atherosclerosis
#17
J S Jensen
Microalbuminuria was recently proposed as a novel atherogenic risk factor. The pathophysiological link between microalbuminuria and atherosclerosis may be mediated through an increased generalized transvascular leakage of albumin. To investigate this hypothesis, urinary albumin excretion and clearance and systemic transvascular albumin leakage (TERalb) were measured in 23 patients with severe clinical atherosclerosis and 25 healthy controls. In addition, renal clearances of three other endogenous plasma proteins (IgG, IgG4, and beta 2-microglobulin) and of creatinine were measured...
September 1995: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/3652535/restriction-of-human-igg-subclass-expression-in-the-population-of-auto-antibodies-to-glomerular-basement-membrane
#18
C Bowman, K Ambrus, C M Lockwood
To study the possible relationship between individual subclass expression and pathogenesis of antibody-mediated disease, we examined the immunoglobulin-G subclass of antiglomerular basement membrane (GBM) antibodies, in the sera of 20 patients with auto-antibody mediated nephritis, as well as in a limited number of kidney eluates, using a solid phase radioimmunoassay and monoclonal antibodies specific for human IgG subclasses. Only anti-GBM antibodies of the IgG1 and/or IgG4 subclass were detectable, both in the circulation and in renal eluates...
August 1987: Clinical and Experimental Immunology
1
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"