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Event related potential schizophrenia

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https://www.readbyqxmd.com/read/28516807/neurofeedback-based-enhancement-of-single-trial-auditory-evoked-potentials-feasibility-in-healthy-subjects
#1
Kathryn Rieger, Marie-Helene Rarra, Nicolas Moor, Laura Diaz Hernandez, Anja Baenninger, Nadja Razavi, Thomas Dierks, Daniela Hubl, Thomas Koenig
Previous studies showed a global reduction of the event-related potential component N100 in patients with schizophrenia, a phenomenon that is even more pronounced during auditory verbal hallucinations. This reduction assumingly results from dysfunctional activation of the primary auditory cortex by inner speech, which reduces its responsiveness to external stimuli. With this study, we tested the feasibility of enhancing the responsiveness of the primary auditory cortex to external stimuli with an upregulation of the event-related potential component N100 in healthy control subjects...
May 1, 2017: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/28506707/complex-mismatch-negativity-to-tone-pair-deviants-in-long-term-schizophrenia-and-in-the-first-episode-schizophrenia-spectrum
#2
Dean F Salisbury, Alexis G McCathern, Brian A Coffman, Timothy K Murphy, Sarah M Haigh
Mismatch negativity (MMN) is an event-related potential to stimulus change. MMN to infrequent deviant tones that differs in a simple physical parameter from repetitive standard tones is reduced in patients with long-term schizophrenia (Sz; d=~1). However, this simple MMN is not uniformly reduced at the first-episode of schizophrenia-spectrum psychosis (FESz; d<0.1 for pitch; <0.4 for duration). Deviant stimuli that violate pattern rules also evoke MMN. This complex MMN is evoked by deviations in the relation of sounds to each other...
May 12, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28473782/neurophysiological-evidence-of-compensatory-brain-mechanisms-underlying-attentional-related-processes-in-symptomatically-remitted-patients-with-schizophrenia
#3
Guoliang Chen, Weiyan Ding, Lei Zhang, Hong Cui, Zhongdong Jiang, Yansong Li
A recent electrophysiological study suggests existing compensatory brain activity as a mechanism for functional recovery of visual attention detection (the capacity for detecting external cues) in symptomatically remitted schizophrenia patients. Despite such evidence, little is known about other aspects of attentional-related processes in schizophrenia during clinical remission, such as their capacity to concentrate on the task at hands without being interfered by distracting information. To this end, we recorded event-related brain potentials (ERPs) from 20 symptomatically remitted schizophrenia patients and 20 healthy controls while they engaged in a classic Stroop task...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28460282/deficits-in-go-and-nogo-p3-potentials-in-patients-with-schizophrenia
#4
Erhan Ertekin, Alp Üçok, Yasemin Keskin-Ergen, Müge Devrim-Üçok
Cognitive control processes elicited during a cued continuous performance test were evaluated using event-related potentials in 46 patients who were within the first 5 years of diagnosis of schizophrenia, and 29 healthy controls. Patients had longer reaction times, lower hit rates, and higher false alarm rates compared with controls. Patients had an overall P3 amplitude reduction that was more prominent on NoGo compared with Go trials. This greater P3 reduction on NoGo trials was present in central and parietal regions, but was absent in the frontal region, where the P3 reduction was comparable on NoGo and Go trials...
April 24, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28450056/mismatch-negativity-in-bipolar-disorder-a-neurophysiological-biomarker-of-intermediate-effect
#5
Daniel F Hermens, Kate M Chitty, Manreena Kaur
The event-related potential, mismatch negativity (MMN), has been touted as a robust and specific neurophysiological biomarker of schizophrenia. Earlier studies often included bipolar disorder (BD) as a clinical comparator and reported that MMN was significantly impaired only in schizophrenia. However, with the increasing number of MMN studies of BD (with larger sample sizes), the literature is now providing somewhat consistent evidence of this biomarker also being perturbed in BD, albeit to a lesser degree than that observed in schizophrenia...
April 24, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28424430/exploring-non-stationarity-patterns-in-schizophrenia-neural-reorganization-abnormalities-in-the-alpha-band
#6
Pablo Núñez, Jesus Poza, Alejandro Bachiller, Javier Gomez-Pilar, Alba Lubeiro, Vicente Molina, Roberto Hornero
OBJECTIVE: The aim of this paper was to characterize brain non-stationarity during an auditory oddball task in schizophrenia (SCH). The level of non-stationarity was measured in the baseline and response windows of relevant tones in SCH patients and healthy controls. APPROACH: Event-related potentials were recorded from 28 SCH patients and 51 controls. Non-stationarity was estimated in the conventional electroencephalography frequency bands by means of Kullback-Leibler divergence (KLD)...
April 20, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28400070/decomposing-p300-into-correlates-of-genetic-risk-and-current-symptoms-in-schizophrenia-an-inter-trial-variability-analysis
#7
Minah Kim, Tak Hyung Lee, Ji-Hun Kim, Hanwoom Hong, Tae Young Lee, Youngjo Lee, Dean F Salisbury, Jun Soo Kwon
BACKGROUND: The P300 event-related potential (ERP) component, which reflects cognitive processing, is a candidate biomarker for schizophrenia. However, the role of P300 in the pathophysiology of schizophrenia remains unclear because averaged P300 amplitudes reflect both genetic predisposition and current clinical status. Thus, we sought to identify which aspects of P300 are associated with genetic risk versus symptomatic status via an inter-trial variability analysis. METHODS: Auditory P300, clinical symptoms, and neurocognitive function assessments were obtained from forty-five patients with schizophrenia, thirty-two subjects at genetic high risk (GHR), thirty-two subjects at clinical high risk (CHR), and fifty-two healthy control (HC) participants...
April 8, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28385587/late-deviance-detection-in-rats-is-reduced-while-early-deviance-detection-is-augmented-by-the-nmda-receptor-antagonist-mk-801
#8
L Harms, W R Fulham, J Todd, C Meehan, U Schall, D M Hodgson, P T Michie
One of the most robust electrophysiological features of schizophrenia is reduced mismatch negativity, a component of the event related potential (ERP) induced by rare and unexpected stimuli in an otherwise regular pattern. Emerging evidence suggests that mismatch negativity (MMN) is not the only ERP index of deviance detection in the mammalian brain and that sensitivity to deviant sounds in a regular background can be observed at earlier latencies in both the human and rodent brain. Pharmacological studies in humans and rodents have previously found that MMN reductions similar to those seen in schizophrenia can be elicited by N-methyl-d-aspartate (NMDA) receptor antagonism, an observation in agreement with the hypothesised role of NMDA receptor hypofunction in schizophrenia pathogenesis...
April 3, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28343741/time-as-context-the-influence-of-hierarchical-patterning-on-sensory-inference
#9
Juanita Todd, Anne Petherbridge, Bronte Speirs, Alexander Provost, Bryan Paton
Time, or more specifically temporal structure, is a critical variable in understanding how the auditory system uses acoustic patterns to predict input, and to filter events based on their relevance. A key index of this filtering process is the auditory evoked potential component known as mismatch negativity or MMN. In this paper we review findings of smaller MMN in schizophrenia through the lens of time as an influential contextual variable. More specifically, we review studies that show how MMN to a locally rare pattern-deviation is modulated by the longer-term context in which it occurs...
March 23, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28290080/a-retrospective-cohort-study-of-acute-kidney-injury-risk-associated-with-antipsychotics
#10
Yawen Jiang, Jeffrey S McCombs, Susie H Park
BACKGROUND: A recent large database analysis raised concerns of potential acute kidney injury (AKI) risk associated with antipsychotics. However, whether individual atypical and typical antipsychotics are associated with differential AKI risks has not been investigated. OBJECTIVE: The current study compared the risks of AKI and known causes of AKI associated with a broad range of atypical and typical antipsychotics. METHOD: This retrospective cohort analysis used January 2007-June 2013 US nationwide Humana claims data to define episodes of antipsychotic drug therapy for patients with schizophrenia and bipolar disorder...
March 13, 2017: CNS Drugs
https://www.readbyqxmd.com/read/28283557/electrophysiological-evidence-for-hyperfocusing-of-spatial-attention-in-schizophrenia
#11
Johanna Kreither, Javier Lopez-Calderon, Carly J Leonard, Benjamin M Robinson, Abigail Ruffle, Britta Hahn, James M Gold, Steven J Luck
A recently proposed hyperfocusing hypothesis of cognitive dysfunction in schizophrenia proposes that people with schizophrenia (PSZ) tend to concentrate processing resources more narrowly but more intensely than healthy control subjects (HCS). The present study tests a key prediction of this hypothesis, namely, that PSZ will hyperfocus on information presented at the center of gaze. This should lead to greater filtering of peripheral stimuli when the task requires focusing centrally but reduced filtering of central stimuli when the task requires attending broadly in the periphery...
April 5, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28250567/feasibility-of-online-neuromodulation-using-transcranial-alternating-current-stimulation-in-schizophrenia
#12
Vanteemar S Sreeraj, Vandita Shanbhag, Hema Nawani, Venkataram Shivakumar, Dinakaran Damodharan, Anushree Bose, Janardhanan C Narayanaswamy, Ganesan Venkatasubramanian
Abnormalities in resting and event-related brain oscillations are known to be associated with cognitive deficits in schizophrenia. Transcranial alternating current stimulation (tACS) modulates these rhythms across the neuronal circuits and could have a potential therapeutic role in psychiatric disorders. In this report, we describe, for the first time, application of online tACS in a schizophrenia patient with working memory deficits. This case report supports the feasibility and potential utility of online tACS in schizophrenia, which needs further systematic research...
January 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28245266/longitudinal-changes-in-prospective-memory-and-their-clinical-correlates-at-1-year-follow-up-in-first-episode-schizophrenia
#13
Fu-Chun Zhou, Chuan-Yue Wang, Gabor S Ungvari, Chee H Ng, Yan Zhou, Liang Zhang, Jingjing Zhou, David H K Shum, David Man, Deng-Tang Liu, Jun Li, Yu-Tao Xiang
This study aimed to investigate prospective memory (PM) and the association with clinical factors at 1-year follow-up in first-episode schizophrenia (FES). Thirty-two FES patients recruited from a university-affiliated psychiatric hospital in Beijing and 17 healthy community controls (HCs) were included. Time- and event-based PM (TBPM and EBPM) performances were measured with the Chinese version of the Cambridge Prospective Memory Test (C-CAMPROMPT) at baseline and at one-year follow-up. A number of other neurocognitive tests were also administered...
2017: PloS One
https://www.readbyqxmd.com/read/28218788/case-report-dysregulation-of-gene-expression-in-a-patient-with-depressive-disorder-after-transient-ischemic-attack-confirmed-by-a-neurophysiological-neuromarker
#14
M Trystuła, M Żychowska, M Wilk-Frańczuk, J D Kropotov, M Pąchalska
The aim of this study was to evaluate dysregulation of gene expression associated with the cellular stress response in a patient with a post-"warning stroke" depressive disorder confirmed by the presence of a neurophysiological neuromarker through the use of quantitative EEG and event-related potentials. The patient was tested for seven genes associated with the stress reaction: HSPA1A, HSPB1, IL6, IL10, CRP, and HSF-1 along with NF-κB, compared to gene expression in health controls. A 54-year-old patient with a past history of schizophrenia (at the age of 20), and of transient ischemic attack (at the age of 53) and depressive disorder confirmed by functional, cognitive, emotional, and affectional diagnostics underwent additional testing for expression of the genes associated with stress response...
February 16, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28197005/p300-and-neuropsychological-measurements-in-patients-with-schizophrenia-and-their-healthy-biological-siblings
#15
D Vijaya Raghavan, Arumugam Shanmugiah, P Bharathi, Ramasamy Jeyaprakash
BACKGROUND: Patients with schizophrenia and their first-degree relatives' exhibit abnormalities in neuropsychological and electrophysiological measures especially P300. The aim was to study the P300 and neuropsychological measures together in patients with schizophrenia, their unaffected siblings, and normal controls. MATERIALS AND METHODS: Thirty patients diagnosed as schizophrenia, their unaffected biological siblings, and normal controls were included in the study...
October 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28192769/disorganization-at-the-stage-of-schizophrenia-clinical-outcome-clinical-biological-study
#16
A Nestsiarovich, V Obyedkov, H Kandratsenka, M Siniauskaya, I Goloenko, N Waszkiewicz
BACKGROUND: According to the multidimensional model of schizophrenia, three basic psychopathological dimensions constitute its clinical structure: positive symptoms, negative symptoms and disorganization. The latter one is the newest and the least studied. Our aim was to discriminate disorganization in schizophrenia clinical picture and to identify its distinctive biological and socio-psychological particularities and associated genetic and environmental factors. METHODS: We used SAPS/SANS psychometrical scales, scales for the assessment of patient's compliance, insight, social functioning, life quality...
May 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28187217/electrophysiological-cognitive-and-clinical-profiles-of-at-risk-mental-state-the-longitudinal-minds-in-transition-mint-study
#17
Rebbekah J Atkinson, W Ross Fulham, Patricia T Michie, Philip B Ward, Juanita Todd, Helen Stain, Robyn Langdon, Renate Thienel, Georgie Paulik, Gavin Cooper, Ulrich Schall
The onset of schizophrenia is typically preceded by a prodromal period lasting several years during which sub-threshold symptoms may be identified retrospectively. Clinical interviews are currently used to identify individuals who have an ultra-high risk (UHR) of developing a psychotic illness with a view to provision of interventions that prevent, delay or reduce severity of future mental health issues. The utility of bio-markers as an adjunct in the identification of UHR individuals is not yet established...
2017: PloS One
https://www.readbyqxmd.com/read/28185228/failures-of-cognitive-control-or-attention-the-case-of-stop-signal-deficits-in-schizophrenia
#18
Dora Matzke, Matthew Hughes, Johanna C Badcock, Patricia Michie, Andrew Heathcote
We used Bayesian cognitive modelling to identify the underlying causes of apparent inhibitory deficits in the stop-signal paradigm. The analysis was applied to stop-signal data reported by Badcock et al. (Psychological Medicine 32: 87-297, 2002) and Hughes et al. (Biological Psychology 89: 220-231, 2012), where schizophrenia patients and control participants made rapid choice responses, but on some trials were signalled to stop their ongoing response. Previous research has assumed an inhibitory deficit in schizophrenia, because estimates of the mean time taken to react to the stop signal are longer in patients than controls...
May 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/28167837/neural-mechanisms-of-mismatch-negativity-dysfunction-in-schizophrenia
#19
M Lee, P Sehatpour, M J Hoptman, P Lakatos, E C Dias, J T Kantrowitz, A M Martinez, D C Javitt
Schizophrenia is associated with cognitive deficits that reflect impaired cortical information processing. Mismatch negativity (MMN) indexes pre-attentive information processing dysfunction at the level of primary auditory cortex. This study investigates mechanisms underlying MMN impairments in schizophrenia using event-related potential, event-related spectral decomposition (ERSP) and resting state functional connectivity (rsfcMRI) approaches. For this study, MMN data to frequency, intensity and duration-deviants were analyzed from 69 schizophrenia patients and 38 healthy controls...
February 7, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28153339/characterization-of-admission-types-in-medically-hospitalized-patients-prescribed-clozapine
#20
Jonathan G Leung, M Earth Hasassri, Jason N Barreto, Sarah Nelson, Robert J Morgan
BACKGROUND: Clozapine is the antipsychotic of choice for treatment-resistant schizophrenia; however, rigorous monitoring is required to prevent or detect adverse drug events that contribute to morbidity and mortality. In addition to the Food and Drug Administration (FDA) boxed safety warnings specific to clozapine (agranulocytosis, hypotension, seizures, and cardiomyopathy/myocarditis), other adverse events such as pneumonia and gastrointestinal hypomotility have been reported in the literature to result in hospitalization...
March 2017: Psychosomatics
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