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Event related potential schizophrenia

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https://www.readbyqxmd.com/read/29338621/assessing-the-acute-effects-of-cdp-choline-on-sensory-gating-in-schizophrenia-a-pilot-study
#1
Robert Aidelbaum, Alain Labelle, Ashley Baddeley, Verner Knott
Deficient sensory gating (SG) in schizophrenia is associated with functional outcome and offers a therapeutic target as it is linked to the altered function/expression of the α7 nicotinic acetylcholine receptors (nAChRs). This study analyzed the effects of citicoline (CDP-choline), a supplement with α7 nAChRs agonist properties, on SG in a sample of schizophrenia (SZ) patients. Using a randomized, placebo-controlled, double-blind design the dose-dependent (500 mg, 1000 mg, 2000 mg) and baseline-dependent (deficient versus normal suppressors) effects of CDP-choline on SG were examined using the P50 event-related potential (ERP) index of SG...
January 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29302713/psilocybin-disrupts-sensory-and-higher-order-cognitive-processing-but-not-pre-attentive-cognitive-processing-study-on-p300-and-mismatch-negativity-in-healthy-volunteers
#2
Anna Bravermanová, Michaela Viktorinová, Filip Tylš, Tomáš Novák, Renáta Androvičová, Jakub Korčák, Jiří Horáček, Marie Balíková, Inga Griškova-Bulanova, Dominika Danielová, Přemysl Vlček, Pavel Mohr, Martin Brunovský, Vlastimil Koudelka, Tomáš Páleníček
RATIONALE: Disruption of auditory event-related evoked potentials (ERPs) P300 and mismatch negativity (MMN), electrophysiological markers of attentive and pre-attentive cognitive processing, is repeatedly described in psychosis and schizophrenia. Similar findings were observed in a glutamatergic model of psychosis, but the role of serotonergic 5-HT2A receptors in information processing is less clear. OBJECTIVES: We studied ERPs in a serotonergic model of psychosis, induced by psilocybin, a psychedelic with 5-HT2A/C agonistic properties, in healthy volunteers...
January 5, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29243531/impact-of-reward-and-loss-anticipation-on-cognitive-control-an-event-related-potential-study-in-subjects-with-schizophrenia-and-healthy-controls
#3
Annarita Vignapiano, Armida Mucci, Eleonora Merlotti, Giulia Maria Giordano, Antonella Amodio, Davide Palumbo, Silvana Galderisi
INTRODUCTION: Deficits of cognitive functions and motivation are core aspects of schizophrenia. The interaction of these deficits might contribute to impair the ability to flexibly adjust behavior in accordance with one's intentions and goals. Many studies have focused on the anterior N2 as a correlate of cognitive control based on motivational value. AIMS: Given the key role of motivation impairment in schizophrenia as a predictor of functional outcome, we aimed to study the impact of reward- and avoidance-based motivation on cognitive control using N2...
January 2018: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/29202656/clinical-and-cognitive-significance-of-auditory-sensory-processing-deficits-in-schizophrenia
#4
Holly K Hamilton, Terrance J Williams, Joseph Ventura, Leland J Jasperse, Emily M Owens, Gregory A Miller, Kenneth L Subotnik, Keith H Nuechterlein, Cindy M Yee
OBJECTIVE: Although patients with schizophrenia exhibit impaired suppression of the P50 event-related brain potential in response to the second of two identical auditory stimuli during a paired-stimulus paradigm, uncertainty remains over whether this deficit in inhibitory gating of auditory sensory processes has relevance for patients' clinical symptoms or cognitive performance. The authors examined associations between P50 suppression deficits and several core features of schizophrenia to address this gap...
December 5, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29198197/the-incidence-of-very-late-onset-psychotic-disorders-a-systematic-review-and-meta-analysis-1960-2016
#5
Jean Stafford, Robert Howard, James B Kirkbride
A substantial subset of people with psychotic disorders are first diagnosed in old age, yet little is known about the epidemiology of very late-onset schizophrenia-like psychosis. We investigated the incidence of affective and non-affective psychotic disorders in those aged 65 and above, and examined variation related to potential risk factors via systematic literature review. We searched PubMed, PsychInfo, Web of Science and bibliographies and directly contacted authors to obtain citations published between 1960 and 2016 containing (derivable) incidence data...
December 4, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29179910/meaning-in-meaninglessness-the-propensity-to-perceive-meaningful-patterns-in-coincident-events-and-randomly-arranged-stimuli-is-linked-to-enhanced-attention-in-early-sensory-processing
#6
Christian Rominger, Günter Schulter, Andreas Fink, Elisabeth M Weiss, Ilona Papousek
Perception of objectively independent events or stimuli as being significantly connected and the associated proneness to perceive meaningful patterns constitute part of the positive symptoms of schizophrenia, which are associated with altered attentional processes in lateralized speech perception. Since perceiving meaningful patterns is to some extent already prevalent in the general population, the aim of the study was to investigate whether the propensity to experience meaningful patterns in co-occurring events and random stimuli may be associated with similar altered attentional processes in lateralized speech perception...
November 24, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29177572/aripiprazole-lauroxil-a-review-in-schizophrenia
#7
James E Frampton
Aripiprazole lauroxil long-acting injectable (LAI) [Aristada®] is an intramuscularly administered, extended-release prodrug of aripiprazole, an established atypical antipsychotic agent that, in terms of its relative position within the class, is at the low end of the risk spectrum for metabolic side effects. In the USA, aripiprazole lauroxil LAI is indicated for the treatment of schizophrenia; approved doses of the drug can be injected once-monthly (q4w), every 6 weeks (q6w) or every 2 months (q8w). The efficacy of the 441 and 882 mg q4w dosages in the treatment of acute exacerbations of schizophrenia and as long-term maintenance therapy in stable schizophrenia has been directly demonstrated in a phase III clinical trial and extension, while the efficacy of the 662 mg q4w, 882 mg q6w and 1064 mg q8w dosing regimens has been established on the basis of pharmacokinetic bridging studies...
November 25, 2017: Drugs
https://www.readbyqxmd.com/read/29175199/towards-a-neurodynamical-understanding-of-the-prodrome-in-schizophrenia
#8
REVIEW
E Mikanmaa, T Grent-'t-Jong, Hua Lingling, M Recasens, H Thune, Peter J Uhlhaas
The identification of biomarkers for the early diagnosis of schizophrenia that could inform novel treatment developments is an important objective of current research. This paper will summarize recent work that has investigated changes in oscillatory activity and event-related potentials with Electro/Magnetoencephalography (EEG/MEG) in participants at high-risk for the development of schizophrenia, highlighting disruptions in sensory and cognitive operations prior to the onset of the syndrome. Changes in EEG/MEG-data are consistent with evidence for alterations in Glutamatergic and GABAergic neurotransmission as disclosed by Magnetic Resonance Spectroscopy and brain stimulation, indicating changes in Excitation/Inhibition Parameters prior to the onset of psychosis...
November 21, 2017: NeuroImage
https://www.readbyqxmd.com/read/29155808/a-hierarchical-stochastic-model-for-bistable-perception
#9
Stefan Albert, Katharina Schmack, Philipp Sterzer, Gaby Schneider
Viewing of ambiguous stimuli can lead to bistable perception alternating between the possible percepts. During continuous presentation of ambiguous stimuli, percept changes occur as single events, whereas during intermittent presentation of ambiguous stimuli, percept changes occur at more or less regular intervals either as single events or bursts. Response patterns can be highly variable and have been reported to show systematic differences between patients with schizophrenia and healthy controls. Existing models of bistable perception often use detailed assumptions and large parameter sets which make parameter estimation challenging...
November 20, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29140804/exploration-of-predictive-biomarkers-for-sudden-unexplained-cardiac-death-in-nonelderly-people-a-case-control-study-with-biochemical-parameters-related-to-heart-failure
#10
Sakai Kentaro, Iwadate Kimiharu, Matsumoto Sari, Takasu Shojiro, Kanto Yuko
Sudden unexplained cardiac death (SUCD) can occasionally occur in nonelderly patients with epilepsy, psychiatric disorders, or no medical history. This study was conducted to aim to analyze whether values of the biomarkers for heart failure are associated with the SUCD. Serum concentrations of N-terminal probrain natriuretic peptide, high-sensitivity C-reactive protein (hs-CRP), and tumor necrosis factor α were analyzed in 57 nonelderly patients with SUCD who was diagnosed at medicolegal autopsy. The subjects were divided into 3 subgroups according to the medical history: (1) epilepsy, (2) psychiatric disorders, and (3) no specific medical history...
November 15, 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/29094613/the-difficulty-in-finding-relationships-between-erps-and-clinical-symptoms-of-schizophrenia
#11
Judith M Ford
It has been surprisingly difficult to find associations between neural signatures of schizophrenia and the symptoms that define it. That is, many of the legacy components of the event-related potential (ERP)- P50, N100, P200, P300-are reduced in patients with schizophrenia, in first-degree relatives of patients with schizophrenia, in schizophrenia patients early in their illness, and even in people at clinical high risk for schizophrenia. Nevertheless, these ERP components tend to be relatively insensitive to symptoms...
October 1, 2017: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/29089771/a-multicenter-open-label-pilot-study-evaluating-the-functionality-of-an-integrated-call-center-for-a-digital-medicine-system-to-optimize-monitoring-of-adherence-to-oral-aripiprazole-in-adult-patients-with-serious-mental-illness
#12
Alex Kopelowicz, Ross A Baker, Cathy Zhao, Claudette Brewer, Erica Lawson, Timothy Peters-Strickland
BACKGROUND: Medication nonadherence is common in the treatment of serious mental illness (SMI) and leads to poor outcomes. The digital medicine system (DMS) objectively measures adherence with oral aripiprazole in near-real time, allowing recognition of adherence issues. This pilot study evaluated the functionality of an integrated call center in optimizing the use of the DMS. MATERIALS AND METHODS: An 8-week, open-label, single-arm trial at four US sites enrolled adults with bipolar I disorder, major depressive disorder, and schizophrenia on stable oral aripiprazole doses and willing to use the DMS (oral aripiprazole + ingestible event marker [IEM], IEM-detecting skin patch, and software application)...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29081922/a-tolerability-burden-index-in-schizophrenia-incorporating-patient-perspective-in-clinical-trial-adverse-event-reporting
#13
Clément François, Alice Guiraud-Diawara, Christophe Lançon, Pierre Michel Llorca, Ann Hartry, Lene Hammer-Helmich, Djamel A Zighed, Adrian Tanasescu, Mondher Toumi
Background: Adverse event (AE) reporting in clinical trials does not fully capture the patient-level perspective and comparing tolerability across treatments or among studies is difficult. Objective: This study was designed to develop a treatment tolerability index algorithm that combines AE reporting with physician- and patient-level AE information into a global burden score to allow comparison of the overall tolerability of antipsychotic medications used in treating schizophrenia. Study design: Data from a 4-arm, placebo-controlled clinical trial were used in the proposed tolerability index algorithm...
2017: Journal of Market Access & Health Policy
https://www.readbyqxmd.com/read/29065422/acute-phencyclidine-alters-neural-oscillations-evoked-by-tones-in-the-auditory-cortex-of-rats
#14
Ashley M Schnakenberg Martin, Brian F OʼDonnell, James B Millward, Jenifer L Vohs, Emma Leishman, Amanda R Bolbecker, Olga Rass, Sandra L Morzorati
BACKGROUND/AIMS: The onset response to a single tone as measured by electroencephalography (EEG) is diminished in power and synchrony in schizophrenia. Because neural synchrony, particularly at gamma frequencies (30-80 Hz), is hypothesized to be supported by the N-methyl-D-aspartate receptor (NMDAr) system, we tested whether phencyclidine (PCP), an NMDAr antagonist, produced similar deficits to tone stimuli in rats. METHODS: Experiment 1 tested the effect of a PCP dose (1...
October 24, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/29051085/40hz-auditory-steady-state-response-in-schizophrenia-sensitivity-to-stimulation-type-clicks-versus-flutter-amplitude-modulated-tones
#15
Inga Griskova-Bulanova, Kastytis Dapsys, Sigita Melynyte, Aleksandras Voicikas, Valentinas Maciulis, Sergejus Andruskevicius, Milena Korostenskaja
Auditory steady-state response (ASSR) at 40Hz has been proposed as a potential biomarker for schizophrenia. The ASSR studies in patients have used click stimulation or amplitude-modulated tones. However, the sensitivity of 40Hz ASSRs to different stimulation types in the same group of patients has not been previously evaluated. Two stimulation types for ASSRs were tested in this study: (1) 40Hz clicks and (2) flutter-amplitude modulated tones. The mean phase-locking index, evoked amplitude and event-related spectral perturbation values were compared between schizophrenia patients (n=26) and healthy controls (n=20)...
October 16, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29036701/mismatch-negativity-but-not-p300-is-associated-with-functional-disability-in-schizophrenia
#16
Holly K Hamilton, Veronica B Perez, Judith M Ford, Brian J Roach, Judith Jaeger, Daniel H Mathalon
Mismatch negativity (MMN) and P300 event-related potential (ERP) reductions in schizophrenia (SZ) reflect preattentive and attention-mediated auditory processing deficits, respectively. Although both have been linked to cognitive deficits in SZ, their relative contributions to real-world functioning are unclear. We sought to determine the functional significance of disrupted auditory processing in SZ by examining MMN and P300 in typically disabled low-functioning patients and in patients with high levels of independent role functioning...
August 3, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29033283/developmental-trajectory-of-mismatch-negativity-and-visual-event-related-potentials-in-healthy-controls-implications-for-neurodevelopmental-vs-neurodegenerative-models-of-schizophrenia
#17
Cheryl M Corcoran, Anastasia Stoops, Migyung Lee, Antigona Martinez, Pejman Sehatpour, Elisa C Dias, Daniel C Javitt
Sensory processing deficits are core features of schizophrenia, reflected in impaired generation of event-related potential (ERP) measures such as auditory mismatch negativity (MMN) and visual P1. To understand the potential time course of development of deficits in schizophrenia, we obtained MMN to unattended duration, intensity and frequency deviants, and visual P1 to attended LSF stimuli, in 43 healthy individuals ages 6 to 25years (mean 17), and compared results to data from 30 adult schizophrenia patients (mean age 38)...
October 12, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29033280/the-contribution-of-the-contingent-negative-variation-cnv-to-goal-maintenance
#18
Aihua Shen, Wan Zhao, Bingqian Han, Qiumei Zhang, Zhifang Zhang, Xiongying Chen, Jinguo Zhai, Min Chen, Boqi Du, Xiaoxiang Deng, Feng Ji, Chuanyue Wang, Yu-Tao Xiang, Hongjie Wu, Qi Dong, Chuansheng Chen, Jun Li
The dot pattern expectancy (DPX) task has been strongly recommended as a measure of goal maintenance, which is impaired in schizophrenia patients. The current event-related potential (ERP) study was designed mainly to identify the ERP component that could represent the goal maintenance process of the DPX task as indexed by the error rate of the BX vs. AY (EBX-AY). We focused our analysis on the cue-phased contingent negative variation (CNV) and found a significant association between the EBX-AY and the amplitude of the difference wave of cue B vs...
October 12, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28961775/brain-responses-at-encoding-predict-limited-verbal-memory-retrieval-by-persons-with-schizophrenia
#19
Julia M Longenecker, Noah C Venables, Seung Suk Kang, Kathryn A McGuire, Scott R Sponheim
Objective: Special attention has been given to verbal memory deficits in schizophrenia because they are apparent in healthy biological relatives of affected individuals, indicating a link to genetic risk for the disorder. Despite a growing consensus that encoding abnormalities contribute to poor verbal memory in the disorder, few studies have directly examined how neural responses during encoding contribute to later memory performance. Method: We evaluated event-related potentials (ERPs) during encoding of verbal material by patients with schizophrenia, healthy first-degree biological relatives of patients, and healthy controls...
September 15, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28927552/mismatch-negativity-impairment-is-associated-with-deficits-in-identifying-real-world-environmental-sounds-in-schizophrenia
#20
Yash B Joshi, Barbara Breitenstein, Melissa Tarasenko, Michael L Thomas, Wei-Li Chang, Joyce Sprock, Richard F Sharp, Gregory A Light
BACKGROUND: Patients with schizophrenia (SZ) have impairments in processing auditory information that have been linked to deficits in cognitive and psychosocial functioning. Dysfunction in auditory sensory processing in SZ has been indexed by mismatch negativity (MMN), an event-related potential evoked by a rare, deviant stimulus embedded within a sequence of identical standard stimuli. Although MMN deficits in SZ have been studied extensively, relatively little is known about how these deficits relate to accurately identifying real-world, ecologically-salient sounds...
September 15, 2017: Schizophrenia Research
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