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Event related potential schizophrenia

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https://www.readbyqxmd.com/read/28715711/sustained-attention-ability-in-schizophrenia-investigation-of-conflict-monitoring-mechanisms
#1
Marc Hoonakker, Nadège Doignon-Camus, José Eduardo Marques-Carneiro, Anne Bonnefond
OBJECTIVE: The main goal of the current study was to assess, with a time-on-task approach, sustained attention ability in schizophrenia, and to investigate conflict monitoring underlying this ability. METHODS: Behavioral and event-related potentials data (N2 and P3a amplitudes) were recorded in a long-lasting sustained attention Go/NoGo task (sustained attention to response task, SART), over a period of 30min, in 29 patients with schizophrenia and 29 pair-matched healthy subjects...
June 28, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28711472/interactive-effects-of-an-n-methyl-d-aspartate-receptor-antagonist-and-a-nicotinic-acetylcholine-receptor-agonist-on-mismatch-negativity-implications-for-schizophrenia
#2
Holly K Hamilton, Deepak C D'Souza, Judith M Ford, Brian J Roach, Naomi S Kort, Kyung-Heup Ahn, Savita Bhakta, Mohini Ranganathan, Daniel H Mathalon
N-methyl-d-aspartate glutamate receptor (NMDAR) hypofunction has been implicated in the pathophysiology of schizophrenia, including auditory processing abnormalities reflected by the mismatch negativity (MMN) event-related potential component. Evidence suggesting cognitive benefits from nicotine administration, together with the high rate of cigarette use in patients with schizophrenia, has stimulated interest in whether nicotine modulates NMDAR hypofunction. We examined the interactive effects of ketamine, an NMDAR antagonist that produces transient schizophrenia-like neurophysiological effects, and nicotine, a nicotinic acetylcholine receptor (nAChR) agonist, in 30 healthy volunteers to determine whether nicotine prevents or attenuates MMN abnormalities...
July 12, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28709770/meta-analysis-of-mismatch-negativity-to-simple-versus-complex-deviants-in-schizophrenia
#3
Michael Avissar, Shanghong Xie, Blair Vail, Javier Lopez-Calderon, Yuanjia Wang, Daniel C Javitt
Mismatch negativity (MMN) deficits in schizophrenia (SCZ) have been studied extensively since the early 1990s, with the vast majority of studies using simple auditory oddball task deviants that vary in a single acoustic dimension such as pitch or duration. There has been a growing interest in using more complex deviants that violate more abstract rules to probe higher order cognitive deficits. It is still unclear how sensory processing deficits compare to and contribute to higher order cognitive dysfunction, which can be investigated with later attention-dependent auditory event-related potential (ERP) components such as a subcomponent of P300, P3b...
July 11, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28691849/electrophysiological-evidence-for-detrimental-impact-of-a-reappraisal-emotion-regulation-strategy-on-subsequent-cognitive-control-in-schizophrenia
#4
Sara K Sullivan, Gregory P Strauss
In healthy individuals, there is evidence that effective implementation of an emotion regulation strategy has beneficial effects on temporally proximal cognitive control task performance. This effect occurs because both of these processes rely heavily on the prefrontal cortex. Individuals with schizophrenia (SZ) have impairments in both emotion regulation and cognitive control that are driven by structural and functional abnormalities of the prefrontal cortex; however, it is unknown whether emotion regulation attempts fail to benefit subsequently performed cognitive control tasks in people with SZ...
July 2017: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/28664356/signal-of-miscarriage-with-aripiprazole-a-disproportionality-analysis-of-the-japanese-adverse-drug-event-report-database
#5
Takamasa Sakai, Fumiko Ohtsu, Chiyo Mori, Kouichi Tanabe, Nobuyuki Goto
INTRODUCTION: With recent advances in medicines, many patients with schizophrenia have become able to conceive. One common second-generation antipsychotic given to patients with schizophrenia is aripiprazole. The label information of aripiprazole in Japan states that according to one case report "there is a report of miscarriage in clinical trial". OBJECTIVE: The aim of this study was to evaluate the relationship between aripiprazole and miscarriage by conducting a disproportionality analysis of an adverse drug event report database...
June 29, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28661580/a-review-of-endophenotypes-in-schizophrenia-and-autism-the-next-phase-for-understanding-genetic-etiologies
#6
Lisabeth F DiLalla, Megan McCrary, Emma Diaz
Many psychiatric disorders are caused by multiple genes and multiple environmental factors, making the identification of specific genetic risk factors for these disorders difficult. Endophenotypes are behaviors or characteristics that are intermediate between the genotype and a phenotype of interest. Because they are more directly related to the gene action than is the endpoint disorder, they may be useful in the identification of specific genes related to psychiatric disorders and the classification of disorders or traits that share an underlying genetic etiology...
June 29, 2017: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
https://www.readbyqxmd.com/read/28660406/evaluation-of-potentially-prolactin-related-adverse-events-and-sexual-maturation-in-adolescents-with-schizophrenia-treated-with-paliperidone-extended-release-er-for-2-years-a-post-hoc-analysis-of-an-open-label-multicenter-study
#7
Srihari Gopal, Rosanne Lane, Isaac Nuamah, Margaret Copenhaver, Jaskaran Singh, David Hough, Mark Bach, Adam Savitz
BACKGROUND: Elevated prolactin levels (hyperprolactinemia) are a frequent adverse effect of antipsychotic medications, especially in young populations. Prolonged hyperprolactinemia may affect sexual functioning and the onset and progression of puberty. OBJECTIVE: This study assessed potentially prolactin-related treatment-emergent adverse events (PPRL-TEAEs) and sexual maturation during long-term treatment of adolescents with paliperidone extended-release (ER). METHODS: This post hoc analysis of a 2-year open-label multicenter study (NCT00488319) included patients of either sex aged 12-17 years at study enrollment, diagnosed with schizophrenia (Diagnostic and Statistical Manual of Mental Disorders, 4th edition [DSM-IV]) for ≥1 year, who had received one or more adequate antipsychotic treatment prior to enrollment but had not responded sufficiently...
June 28, 2017: CNS Drugs
https://www.readbyqxmd.com/read/28652751/effects-of-canon-chord-progression-on-brain-activity-and-motivation-are-dependent-on-subjective-feelings-not-the-chord-progression-per-se
#8
Yoshinori Kayashima, Kazuhiko Yamamuro, Manabu Makinodan, Yoko Nakanishi, Akio Wanaka, Toshifumi Kishimoto
A number of studies have indicated that relaxing and pleasant melodies are useful for the treatment of patients with psychiatric disorders, including schizophrenia, depression, and dementia. However, few studies have investigated what constitutive elements of the music had an effect on brain activity. As Canon chord progression is one of critical elements for pleasant melodies, we sought to examine the effects of Canon chord progression and pitch-shifted Canon chord progression on brain activity using performance on the auditory oddball task during event-related potentials (ERPs) in 30 healthy subjects...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28639417/auditory-processing-in-autism-spectrum-disorder-mismatch-negativity-deficits
#9
Chantal Vlaskamp, Bob Oranje, Gitte Falcher Madsen, Jens Richardt Møllegaard Jepsen, Sarah Durston, Cathriona Cantio, Birte Glenthøj, Niels Bilenberg
Children with autism spectrum disorders (ASD) often show changes in (automatic) auditory processing. Electrophysiology provides a method to study auditory processing, by investigating event-related potentials such as mismatch negativity (MMN) and P3a-amplitude. However, findings on MMN in autism are highly inconsistent, partly due to small sample sizes in the studies and differences in MMN paradigms. Therefore, in the current study, MMN and P3a amplitude were assessed in a relatively large sample of children with ASD, using a more extensive MMN paradigm and compared with that of typically developing children (TDC)...
June 22, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28620278/revealing-the-dysfunction-of-schematic-facial-expression-processing-in-schizophrenia-a-comparative-study-of-different-references
#10
Shenglin She, Haijing Li, Yuping Ning, Jianjuan Ren, Zhangying Wu, Rongcheng Huang, Jingping Zhao, Qian Wang, Yingjun Zheng
The use of event-related potential (ERP) recording technology during perceptual and cognitive processing has been studied in order to develop objective diagnostic indexes for people with neuropsychiatric disorders. For example, patients with schizophrenia exhibit consistent abnormalities in face-evoked early components of ERPs and mismatch negativities (MMNs). In most studies, the choice of reference has been the average reference (AVE), but whether this is the most suitable choice is still unknown. The aim of this study was to systematically compare the AVE and reference electrode standardization technique (REST) methods for assessing expressional face-evoked early visual ERPs and visual MMNs (vMMNs) in patients with schizophrenia and healthy controls...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28593353/diabetic-ketoacidosis-and-diabetes-associated-with-antipsychotic-exposure-among-a-previously-diabetes-naive-population-with-schizophrenia-a-nationwide-nested-case-control-study
#11
Christoffer Polcwiartek, Kristian Kragholm, Christopher Rohde, Nasseh Hashemi, Torkel Vang, Jimmi Nielsen
AIMS/HYPOTHESIS: Diabetic ketoacidosis (DKA) is a potentially fatal metabolic emergency of both type 1 and type 2 diabetes. Although there is a reduced risk of type 1 diabetes in schizophrenia, the incidence of DKA is tenfold higher than that of the general population. Thus, we aimed to investigate associations between exposure to antipsychotic medication (within 3 months prior to event) and DKA, type 1 diabetes and type 2 diabetes. We also reported related, clinically relevant outcomes...
June 7, 2017: Diabetologia
https://www.readbyqxmd.com/read/28590364/neurophysiological-effects-of-bitopertin-in-schizophrenia
#12
Joshua T Kantrowitz, Karen A Nolan, Michael L Epstein, Nayla Lehrfeld, Constance Shope, Eva Petkova, Daniel C Javitt
PURPOSE/BACKGROUND: Deficits in N-methyl-D-aspartate receptor (NMDAR) function contribute to symptoms and cognitive dysfunction in schizophrenia and are associated with impaired generation of event-related potential measures including auditory mismatch negativity. Parallel studies of the NMDAR agonist D-serine have suggested that sensitivity of these measures to glutamate-based interventions is related to symptomatic and cognitive response. Bitopertin is a selective inhibitor of glycine transport...
August 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28578921/impaired-social-cognition-in-schizophrenia-during-the-ultimatum-game-an-eeg-study
#13
Sibylle K Horat, Grégoire Favre, Anne Prévot, Joseph Ventura, François R Herrmann, Isabelle Gothuey, Marco C G Merlo, Pascal Missonnier
BACKGROUND: Schizophrenia has a core feature of cognitive dysfunctions. Since these deficits are predictive for patients' functional outcome, understanding their origin is of great importance to improve their daily lives. A specific component of the deficit involves social decision-making, which can be studied using the Ultimatum Game (UG). In this task, a "proposer" proposes a share of money to a "responder", who can either accept or reject this offer. If the responder accepts the proposal, both win money...
June 1, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28571801/hypothesis-exosomal-micrornas-as-potential-biomarkers-for-schizophrenia
#14
Vijaya Raghavan, Manish Bhomia, Isabel Torres, Sanjeev Jain, Kevin K Wang
Schizophrenia is a serious mental disorder with lifelong morbidity and increased mortality. Currently, the diagnosis of the disorder is based on patient history and clinical examination, but it has a low inter-rater reliability and validity. Various biological variables, such as event related potentials, hormonal levels, brain ventricular volume and hippocampal size, have been put forth as objective markers to diagnose schizophrenia, but none with the desired sensitivity and specificity. It has been shown that microRNAs play a vital role in gene regulation in schizophrenia and have been proposed as possible biomarkers for the disease...
June 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28560151/auditory-prediction-errors-as-individual-biomarkers-of-schizophrenia
#15
J A Taylor, N Matthews, P T Michie, M J Rosa, M I Garrido
Schizophrenia is a complex psychiatric disorder, typically diagnosed through symptomatic evidence collected through patient interview. We aim to develop an objective biologically-based computational tool which aids diagnosis and relies on accessible imaging technologies such as electroencephalography (EEG). To achieve this, we used machine learning techniques and a combination of paradigms designed to elicit prediction errors or Mismatch Negativity (MMN) responses. MMN, an EEG component elicited by unpredictable changes in sequences of auditory stimuli, has previously been shown to be reduced in people with schizophrenia and this is arguably one of the most reproducible neurophysiological markers of schizophrenia...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28558905/correlates-and-predictors-of-antipsychotic-drug-polypharmacy-in-real-life-settings-results-from-a-nationwide-cohort-study
#16
Leo Malandain, Florence Thibaut, Lamiae Grimaldi-Bensouda, Bruno Falissard, Lucien Abenhaim, Clementine Nordon
Reasons for using antipsychotic polypharmacy (APP) in routine clinical practice, despite a potentially unfavorable risk-benefit ratio, are poorly understood. This research aimed to determine (1) if severe courses of schizophrenia were associated with APP and (2) if a schizophrenia-related acute event would predict a switch to APP in the short term. Observational prospective data (at baseline and 6months) were drawn from a French nationwide cohort ("Cohorte Générale Schizophrénie"), which included 1859 inpatients and outpatients with schizophrenia...
May 27, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28516807/neurofeedback-based-enhancement-of-single-trial-auditory-evoked-potentials-feasibility-in-healthy-subjects
#17
Kathryn Rieger, Marie-Helene Rarra, Nicolas Moor, Laura Diaz Hernandez, Anja Baenninger, Nadja Razavi, Thomas Dierks, Daniela Hubl, Thomas Koenig
Previous studies showed a global reduction of the event-related potential component N100 in patients with schizophrenia, a phenomenon that is even more pronounced during auditory verbal hallucinations. This reduction assumingly results from dysfunctional activation of the primary auditory cortex by inner speech, which reduces its responsiveness to external stimuli. With this study, we tested the feasibility of enhancing the responsiveness of the primary auditory cortex to external stimuli with an upregulation of the event-related potential component N100 in healthy control subjects...
May 1, 2017: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/28506707/complex-mismatch-negativity-to-tone-pair-deviants-in-long-term-schizophrenia-and-in-the-first-episode-schizophrenia-spectrum
#18
Dean F Salisbury, Alexis G McCathern, Brian A Coffman, Timothy K Murphy, Sarah M Haigh
Mismatch negativity (MMN) is an event-related potential to stimulus change. MMN to infrequent deviant tones that differs in a simple physical parameter from repetitive standard tones is reduced in patients with long-term schizophrenia (Sz; d=~1). However, this simple MMN is not uniformly reduced at the first-episode of schizophrenia-spectrum psychosis (FESz; d<0.1 for pitch; <0.4 for duration). Deviant stimuli that violate pattern rules also evoke MMN. This complex MMN is evoked by deviations in the relation of sounds to each other...
May 12, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28473782/neurophysiological-evidence-of-compensatory-brain-mechanisms-underlying-attentional-related-processes-in-symptomatically-remitted-patients-with-schizophrenia
#19
Guoliang Chen, Weiyan Ding, Lei Zhang, Hong Cui, Zhongdong Jiang, Yansong Li
A recent electrophysiological study suggests existing compensatory brain activity as a mechanism for functional recovery of visual attention detection (the capacity for detecting external cues) in symptomatically remitted schizophrenia patients. Despite such evidence, little is known about other aspects of attentional-related processes in schizophrenia during clinical remission, such as their capacity to concentrate on the task at hands without being interfered by distracting information. To this end, we recorded event-related brain potentials (ERPs) from 20 symptomatically remitted schizophrenia patients and 20 healthy controls while they engaged in a classic Stroop task...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28460282/deficits-in-go-and-nogo-p3-potentials-in-patients-with-schizophrenia
#20
Erhan Ertekin, Alp Üçok, Yasemin Keskin-Ergen, Müge Devrim-Üçok
Cognitive control processes elicited during a cued continuous performance test were evaluated using event-related potentials in 46 patients who were within the first 5 years of diagnosis of schizophrenia, and 29 healthy controls. Patients had longer reaction times, lower hit rates, and higher false alarm rates compared with controls. Patients had an overall P3 amplitude reduction that was more prominent on NoGo compared with Go trials. This greater P3 reduction on NoGo trials was present in central and parietal regions, but was absent in the frontal region, where the P3 reduction was comparable on NoGo and Go trials...
April 24, 2017: Psychiatry Research
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