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Event related potential schizophrenia

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https://www.readbyqxmd.com/read/27910804/sudden-cardiac-death-a-nationwide-cohort-study-among-the-young
#1
Bjarke Risgaard
Sudden cardiac death (SCD) is a tragic event affecting millions of individuals worldwide. Although several studies have investigated the epidemiology of SCD, these studies may have been affected by reporting and referral biases, which are reflected in the very different incidence rates and causes of deaths that have previously been reported. Among SCD victims aged < 36 years, inherited cardiac diseases are well known to play an important role. However, the extent to which inherited cardiac diseases also play a role in SCD victims aged < 50 years has not been completely described...
December 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27896651/postnatal-administration-of-dizocilpine-inhibits-neuronal-excitability-in-pfc-and-induces-social-deficits-detected-by-miceprofiler
#2
Dexiao Zhu, Hui Wang, Jintao Wu, Qian Wang, Ling Xu, Yue Zhao, Kunkun Pang, Qingqing Shi, Wenbo Zhao, Jing Zhang, Jinhao Sun
Schizophrenia is a devastating mental disease with social deficit as its core component of negative symptoms, which could be induced in rodents by dizocilpine (MK-801), a noncompetitive NMDA receptor antagonist. NMDA receptors are highly expressed during the postnatal period. However, less attention has been paid to the effects of postnatal MK-801 administration on social interaction. In this study, we evaluated the effects of postnatal administration of MK-801 on social interaction and explored the possible mechanisms...
November 28, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27887704/aberrant-modulation-of-brain-activation-by-emotional-valence-during-self-referential-processing-among-patients-with-delusions-of-reference
#3
Todd A Girard, Louis Lakatos, Mahesh Menon
BACKGROUND AND OBJECTIVES: Delusions of reference are thought to reflect abnormally heightened attributions of salience to mundane events or stimuli that lead to convictions that they are personally significant or directed at the observer. Recent findings highlight abnormal recruitment of brain regions associated with self-referential processes among patients with referential delusions. Given the inherent overlap of emotion, incentive salience, and self-relevance, as well as with aberrant thought processes in psychosis, this study investigated the implicit relations between participants' perception of the emotional valence of stimuli on neural correlates of self-referent judgments among schizophrenia-spectrum patients with referential delusions...
November 17, 2016: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/27846841/integrative-transcriptome-network-analysis-of-ipsc-derived-neurons-from-schizophrenia-and-schizoaffective-disorder-patients-with-22q11-2-deletion
#4
Mingyan Lin, Erika Pedrosa, Anastasia Hrabovsky, Jian Chen, Benjamin R Puliafito, Stephanie R Gilbert, Deyou Zheng, Herbert M Lachman
BACKGROUND: Individuals with 22q11.2 Deletion Syndrome (22q11.2 DS) are a specific high-risk group for developing schizophrenia (SZ), schizoaffective disorder (SAD) and autism spectrum disorders (ASD). Several genes in the deleted region have been implicated in the development of SZ, e.g., PRODH and DGCR8. However, the mechanistic connection between these genes and the neuropsychiatric phenotype remains unclear. To elucidate the molecular consequences of 22q11.2 deletion in early neural development, we carried out RNA-seq analysis to investigate gene expression in early differentiating human neurons derived from induced pluripotent stem cells (iPSCs) of 22q11...
November 15, 2016: BMC Systems Biology
https://www.readbyqxmd.com/read/27825609/cognitive-impairments-in-patients-with-first-episode-psychosis-the-relationship-between-neurophysiological-and-neuropsychological-assessments
#5
Isabel Morales-Muñoz, Rosa Jurado-Barba, Sara Fernández-Guinea, María José Álvarez-Alonso, Roberto Rodríguez-Jiménez, Miguel Angel Jiménez-Arriero, Gabriel Rubio
Cognitive deficits in schizophrenia have been widely reported. Neurophysiological and neuropsychological assessments have been conducted to study these impairments. Event-related potentials (ERPs) are relevant markers of cognitive deficits in schizophrenia, and reductions in specific ERP components have been found. The MATRICS Consensus Cognitive Battery (MCCB) was developed to obtain a consensus battery for the assessment of cognitive deficits in schizophrenia. Here, we aimed to study modulations of several ERP components in first episode psychosis (FEP)...
November 4, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27788312/physician-warnings-in-psychiatry-and-the-risk-of-road-trauma-an-exposure-crossover-study
#6
Andrew J Lustig, Paul A Kurdyak, Deva Thiruchelvam, Donald A Redelmeier
OBJECTIVE: To determine if physician warnings to psychiatric patients alter the subsequent frequency of a motor vehicle crash. A secondary objective was to determine if physician warnings change the subsequent frequency of psychiatric hospitalization. METHODS: Exposure crossover design of 23,145 psychiatric patients diagnosed with ICD-9 schizophrenia (code 295), mood disorder (296), personality disorder (301), or substance use disorder (303, 304) and warned by their physician about driving safety between April 1, 2006, and March 31, 2011...
October 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27755159/peony-glycyrrhiza-decoction-for-antipsychotic-related-hyperprolactinemia-in-women-with-schizophrenia-a-randomized-controlled-trial
#7
Sui Cheung Man, Xian-Bin Li, Huai-Hai Wang, Hai-Ning Yuan, Hua-Ning Wang, Rui-Guo Zhang, Qing-Rong Tan, Hei Kiu Wong, Grainne M McAlonan, Chuan-Yue Wang, Zhang-Jin Zhang
OBJECTIVES: An herbal preparation called peony-glycyrrhiza decoction (PGD) may have the potential in reducing antipsychotic-related hyperprolactinemia (hyperPRL). This double-blind, randomized placebo-controlled study aimed to reevaluate the efficacy of PGD against antipsychotic-related hyperPRL. METHODS: Ninety-nine schizophrenic women who were under antipsychotic therapy and had symptomatic hyperPRL were randomly assigned to additional treatment with placebo (n = 50) or PGD (n = 49, 45 g/d) for 16 weeks...
December 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27752140/the-neural-transfer-effect-of-working-memory-training-to-enhance-hedonic-processing-in-individuals-with-social-anhedonia
#8
Xu Li, Zhi Li, Ke Li, Ya-Wei Zeng, Hai-Song Shi, Wen-Lan Xie, Zhuo-Ya Yang, Simon S Y Lui, Eric F C Cheung, Ada W S Leung, Raymond C K Chan
Anhedonia, the diminished ability to experience pleasure, is a challenging negative symptom in patients with schizophrenia and can be observed in at-risk individuals with schizotypy. Deficits in hedonic processing have been postulated to be related to decreased motivation to engage in potentially rewarding events. It remains unclear whether non-pharmacological interventions, such as cognitive training, could improve anhedonia. The present study aimed to examine the neural mechanism for alleviating hedonic deficits with working memory (WM) training in individuals with social anhedonia...
October 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27720402/the-association-between-first-episode-psychosis-and-abnormal-glycaemic-control-systematic-review-and-meta-analysis
#9
Benjamin Ian Perry, Gemma McIntosh, Scott Weich, Swaran Singh, Karen Rees
BACKGROUND: Schizophrenia might share intrinsic inflammatory disease pathways with type 2 diabetes. We aimed to assess whether first-episode psychosis, which could be described as developing schizophrenia, is associated with prediabetic markers, or developing diabetes, to determine whether intrinsic disease links could cause the disorders to develop in unison. We hypothesised that biochemical measures of prediabetic states would be more common in antipsychotic naive patients with first-episode psychosis than in healthy matched controls...
October 5, 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27709980/hyperfocusing-of-attention-on-goal-related-information-in-schizophrenia-evidence-from-electrophysiology
#10
Risa Sawaki, Johanna Kreither, Carly J Leonard, Samuel T Kaiser, Britta Hahn, James M Gold, Steven J Luck
Schizophrenia clearly involves impairments of attention, but the precise nature of these impairments has been difficult to determine. One possibility is that the deficit in attention is a secondary consequence of a deficit in goal maintenance. However, recent research suggests that people with schizophrenia (PSZ) actually focus attention more strongly on objects containing goal-relevant features. To test these competing hypotheses, we recorded event-related potentials (ERPs) from PSZ (N = 20) and healthy control subjects (HCS; N = 20) while they looked for a particular target color at fixation and tried to ignore lateral distractors that sometimes matched the target color (target-color distractors)...
October 6, 2016: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/27658831/sensory-gating-deficits-and-impaired-quality-of-life-in-patients-with-schizophrenia-a-preliminary-study
#11
Jean-Arthur Micoulaud-Franchi, Mélanie Faugere, Laurent Boyer, Michel Cermolacce, Guillaume Fond, Raphaëlle Richieri, Jean Vion-Dury, Christophe Lancon
BACKGROUND: New determinants of quality of life in schizophrenia need to be identified. As sensory gating deficit is core impairment in schizophrenia, the present study hypothesized that sensory gating deficit is a determinant of impaired quality of life in schizophrenia. This study therefore investigated the relationship between sensory gating deficit and quality of life in patients with schizophrenia after adjusting for key confounding factors. SUBJECTS AND METHODS: Sensory gating was assessed with the auditory event-related potential method by measuring P50 amplitude changes in a double-click conditioning-testing procedure, perceptual impairments related to sensory gating deficit was assessed with the SGI questionnaire and quality of life was assessed with the SQoL 18 questionnaire in 39 patients with schizophrenia...
September 2016: Psychiatria Danubina
https://www.readbyqxmd.com/read/27651012/neuropsychology-of-humor-an-introduction-part-ii-humor-and-the-brain
#12
Christian Derouesné
Impairment of the perception or comprehension of humor is observed in patients with focal brain lesions in both hemispheres, but mainly in the right frontal lobe. Studies by functional magnetic resonance imaging in healthy subjects show that humor is associated with activation of two main neural systems in both hemispheres. The detection and resolution of incongruity, cognitive groundings of humor, are associated with activation of the medial prefrontal and temporoparietal cortex, and the humor appreciation with activation of the orbito-frontal and insular cortex, amygdala and the brain reward system...
September 1, 2016: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/27647218/role-of-n-methyl-d-aspartate-receptors-in-action-based-predictive-coding-deficits-in-schizophrenia
#13
Naomi S Kort, Judith M Ford, Brian J Roach, Handan Gunduz-Bruce, John H Krystal, Judith Jaeger, Robert M G Reinhart, Daniel H Mathalon
BACKGROUND: Recent theoretical models of schizophrenia posit that dysfunction of the neural mechanisms subserving predictive coding contributes to symptoms and cognitive deficits, and this dysfunction is further posited to result from N-methyl-D-aspartate glutamate receptor (NMDAR) hypofunction. Previously, by examining auditory cortical responses to self-generated speech sounds, we demonstrated that predictive coding during vocalization is disrupted in schizophrenia. To test the hypothesized contribution of NMDAR hypofunction to this disruption, we examined the effects of the NMDAR antagonist, ketamine, on predictive coding during vocalization in healthy volunteers and compared them with the effects of schizophrenia...
July 1, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27622140/using-concurrent-eeg-and-fmri-to-probe-the-state-of-the-brain-in-schizophrenia
#14
Judith M Ford, Brian J Roach, Vanessa A Palzes, Daniel H Mathalon
Perceptional abnormalities in schizophrenia are associated with hallucinations and delusions, but also with negative symptoms and poor functional outcome. Perception can be studied using EEG-derived event related potentials (ERPs). Because of their excellent temporal resolution, ERPs have been used to ask when perception is affected by schizophrenia. Because of its excellent spatial resolution, functional magnetic resonance imaging (fMRI) has been used to ask where in the brain these effects are seen. We acquired EEG and fMRI data simultaneously to explore when and where auditory perception is affected by schizophrenia...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27586404/deficits-in-attentional-processing-of-fearful-facial-expressions-in-schizophrenic-patients
#15
Yunzhe Liu, Dandan Zhang, Yanli Zhao, Shuping Tan, Yuejia Luo
Impaired attentional processing of negative facial expressions is prominent in schizophrenia and has been shown to be associated with patients' social dysfunctions. However, little is known about when and which specific attention deficits influence social functions. Given the dynamic feature of attention, it is necessary to investigate the attention deficits in negative emotional processing unfolding in time. The current study used event-related potentials (ERPs) to investigate the temporal dynamics of attention deficits in emotion perception and their potential relationship with emotional/social impairments in neuroleptic naive schizophrenic patients...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27573041/evidence-for-a-differential-contribution-of-early-perceptual-and-late-cognitive-processes-during-encoding-to-episodic-memory-impairment-in-schizophrenia
#16
Amity E Green, Paul B Fitzgerald, Patrick J Johnston, Pradeep J Nathan, Jayashri Kulkarni, Rodney J Croft
OBJECTIVES: Schizophrenia is characterised by significant episodic memory impairment that is thought to be related to problems with encoding, however the neuro-functional mechanisms underlying these deficits are not well understood. The present study used a subsequent recognition memory paradigm and event-related potentials (ERPs) to investigate temporal aspects of episodic memory encoding deficits in schizophrenia. METHODS: Electroencephalographic data was recorded in 24 patients and 19 healthy controls whilst participants categorised single words as pleasant/unpleasant...
August 30, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27570953/-emotional-memory-and-electrocortical-activity-in-schizophrenia
#17
Marc E Lavoie, Julie Champagne, Emma Glaser, Adrianna Mendrek
Context Abnormal emotion processing is frequent in schizophrenia and affects social and functional outcome. Past event-related potential (ERP) research investigating processing of affective stimuli in schizophrenia was done mainly with facial expressions and revealed impaired facial emotion recognition in patients relative to control subjects. Experimentations involving fMRI with this group of patients, showed alteration of limbic and frontal regions in response to emotional unpleasant images, compared to neutral stimuli during a memory task...
2016: Santé Mentale Au Québec
https://www.readbyqxmd.com/read/27547854/verbal-violence-experiences-of-adults-with-serious-mental-illnesses
#18
Nirit Karni-Vizer, Mark S Salzer
OBJECTIVE: Trauma experienced by individuals with serious mental illnesses extends beyond physical and sexual abuse. This is among the first studies to examine verbal violence, both spoken and written words, experienced by individuals with serious mental illnesses. METHOD: Fifty individuals diagnosed with a schizophrenia-spectrum, bipolar, or major depressive disorder were recruited from community-based mental health agencies and reported on their experiences with 8 types of verbal violence identified in the literature, or related written comments, including: belittling, insulting, name-calling, teasing/embarrassing, threatening, cursing, or yelling...
December 2016: Psychiatric Rehabilitation Journal
https://www.readbyqxmd.com/read/27483114/sensory-gating-deficits-in-first-episode-psychosis-evidence-from-neurophysiology-psychophysiology-and-neuropsychology
#19
Isabel Morales-Muñoz, Rosa Jurado-Barba, Sara Fernández-Guinea, Roberto Rodríguez-Jiménez, Miguel Ángel Jiménez-Arriero, José R Criado, Gabriel Rubio
Sensory gating deficits are commonly found in patients with schizophrenia. However, there is still scarce research on this issue. Thirty-eight patients with first-episode psychosis (FEP) were compared to thirty-eight controls. A condition-test paradigm of event-related potentials (ERP), prepulse inhibition (PPI), and some specific tasks of the MATRICS Consensus Cognitive Battery (MCCB) were used (i.e., TMT, BACS-SC, and Fluency for processing speed and CPT-IP for attention and vigilance). The ERP components measured were P50, N1, and P2...
December 2016: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/27471459/mismatch-negativity-to-threatening-voices-associated-with-positive-symptoms-in-schizophrenia
#20
Chenyi Chen, Chia-Chien Liu, Pei-Yuan Weng, Yawei Cheng
Although the general consensus holds that emotional perception is impaired in patients with schizophrenia, the extent to which neural processing of emotional voices is altered in schizophrenia remains to be determined. This study enrolled 30 patients with chronic schizophrenia and 30 controls and measured their mismatch negativity (MMN), a component of auditory event-related potentials (ERP). In a passive oddball paradigm, happily or angrily spoken deviant syllables dada were randomly presented within a train of emotionally neutral standard syllables...
2016: Frontiers in Human Neuroscience
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