keyword
MENU ▼
Read by QxMD icon Read
search

Polymicrobial

keyword
https://www.readbyqxmd.com/read/29343555/antagonism-of-integrin-cd11b-affords-protection-against-endotoxin-shock-and-polymicrobial-sepsis-via-attenuation-of-hmgb1-nucleocytoplasmic-translocation-and-extracellular-release
#1
Huiting Zhou, Yanhong Li, Huan Gui, He Zhao, Ming Wu, Gang Li, Yiping Li, Zhenjiang Bai, Zhimin Yin, H Paul Redmond, Jian Wang, Jiang Huai Wang, Zhihui Zhao
High mobility group box 1 (HMGB1), a chromatin-binding nuclear protein, plays a critical role in sepsis by acting as a key "late-phase" inflammatory mediator. Integrin CD11b is essential for inflammatory cell activation and migration, thus mediating inflammatory responses. However, it is unclear whether CD11b participates in the development of sepsis. In this study, we report that CD11b contributes to LPS-induced endotoxin shock and microbial sepsis, as antagonism of CD11b with the CD11b blocking Ab or CD11b inhibitor Gu-4 protects mice against LPS- and microbial sepsis-related lethality, which is associated with significantly diminished serum HMGB1 levels...
January 17, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29339423/immune-protection-against-lethal-fungal-bacterial-intra-abdominal-infections
#2
Elizabeth A Lilly, Melanie Ikeh, Evelyn E Nash, Paul L Fidel, Mairi C Noverr
Polymicrobial intra-abdominal infections (IAIs) are clinically prevalent and cause significant morbidity and mortality, especially those involving fungi. Our laboratory developed a mouse model of IAI and demonstrated that intraperitoneal inoculation with Candida albicans or other virulent non-albicans Candida (NAC) species plus Staphylococcus aureus resulted in 70 to 80% mortality in 48 to 72 h due to robust local and systemic inflammation (sepsis). Surprisingly, inoculation with Candida dubliniensis or Candida glabrata with S...
January 16, 2018: MBio
https://www.readbyqxmd.com/read/29337224/an-experimental-study-for-rapid-detection-and-quantification-of-endodontic-microbiota-following-photo-activated-disinfection-via-new-multiplex-real-time-pcr-assay
#3
Maryam Pourhajibagher, Reza Raoofian, Roghayeh Ghorbanzadeh, Abbas Bahador
BACKGROUND: The infected root canal system harbors one of the highest accumulations of polymicrobial infections. Since the eradication of endopathogenic microbiota is a major goal in endodontic infection therapy, photo-activated disinfection (PAD) can be used as an alternative therapeutic method in endodontic treatment. Compared to cultivation-based approaches, molecular techniques are more reliable for identifying microbial agents associated with endodontic infections. The purpose of this study was to evaluate the ability of designed multiplex real-time PCR protocol for the rapid detection and quantification of six common microorganisms involved in endodontic infection before and after the PAD...
January 11, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29322874/mrsa-incidence-and-antibiotic-trends-in-urban-hand-infections-a-10-year-longitudinal-study
#4
Justin M Kistler, Joseph J Thoder, Asif M Ilyas
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is the most reported pathogen in hand infections at urban medical centers throughout the country. Antibiotic sensitivity trends are not well known. The purposes of this study were to examine and determine the drug resistance trends for MRSA infections of the hand and to provide recommendations for empiric antibiotic treatment based on sensitivity profiles. METHODS: A 10-year longitudinal, retrospective chart review was performed on all culture-positive hand infections encountered at a single urban medical center from 2005 to 2014...
January 1, 2018: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/29317512/streptococcus-pneumoniae-modulates-staphylococcus-aureus-biofilm-dispersion-and-the-transition-from-colonization-to-invasive-disease
#5
Ryan M Reddinger, Nicole R Luke-Marshall, Shauna L Sauberan, Anders P Hakansson, Anthony A Campagnari
Streptococcus pneumoniae and Staphylococcus aureus are ubiquitous upper respiratory opportunistic pathogens. Individually, these Gram-positive microbes are two of the most common causative agents of secondary bacterial pneumonia following influenza A virus infection, and they constitute a significant source of morbidity and mortality. Since the introduction of the pneumococcal conjugate vaccine, rates of cocolonization with both of these bacterial species have increased, despite the traditional view that they are antagonistic and mutually exclusive...
January 9, 2018: MBio
https://www.readbyqxmd.com/read/29316594/biofilms-their-role-and-treatment-options-in-the-chronic-non-healing-wound
#6
Michael F Moore
The discovery of the existence of biofilms in the 1970s has resulted in a greater understanding of how bacteria form a synergistic relationship to facilitate their survival by incorporating and sharing the individual attributes that individual bacteria have with the polymicrobial flora that composes the biofilm. Advances in molecular biology have aided in delineating complexity of biofilms, but the abundance and plethora of the microbial world provides an ongoing and daunting task. The enormity of this task is reflected in the chronic non-healing wound, as it is estimated that 60% of all chronic non-healing wounds have a biofilm component...
December 22, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29306311/-polymicrobial-lung-infection-associated-with-idelalisib-administration
#7
Adrián Rodríguez-Ferreras, Lucia Velasco-Roces, Eva Lázaro-López, Isabel Zapico-García
No abstract text is available yet for this article.
January 1, 2018: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/29305548/epidemiology-clinical-characteristics-and-antimicrobial-susceptibility-profiles-of-human-clinical-isolates-of-staphylococcus-intermedius-group
#8
Melanie L Yarbrough, William Lainhart, C A Burnham
The veterinary pathogens in Staphylococcus intermedius group (SIG) are increasingly recognized as causes of human infection. Shared features between SIG and Staphylococcus aureus may result in misidentification of SIG in human clinical cultures. This study examined the clinical and microbiological characteristics of isolates recovered at a tertiary care academic medical center. From 2013 to 2015, 81 SIG isolates were recovered from 62 patients. Patients were commonly ≥ 50 years old, diabetic, or immunocompromised...
January 5, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29289808/myd88-mediated-innate-sensing-by-oral-epithelial-cells-controls-periodontal-inflammation
#9
Andrea E Delitto, Fernanda Rocha, Ann M Decker, Byron Amador, Heather L Sorenson, Shannon M Wallet
Periodontal diseases are a class of non-resolving inflammatory diseases, initiated by a pathogenic subgingival biofilm, in a susceptible host, which if left untreated can result in soft and hard tissue destruction. Oral epithelial cells are the first line of defense against microbial infection within the oral cavity, whereby they can sense the environment through innate immune receptors including toll-like receptors (TLRs). Therefore, oral epithelial cells directly and indirectly contribute to mucosal homeostasis and inflammation, and disruption of this homeostasis or over-activation of innate immunity can result in initiation and/or exacerbation of localized inflammation as observed in periodontal diseases...
December 16, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29275129/dysbiosis-of-the-fecal-microbiota-in-feedlot-cattle-with-hemorrhagic-diarrhea
#10
Mohamed Zeineldin, Brian Aldridge, James Lowe
The bovine gastrointestinal microbiota is a complex polymicrobial ecosystem that plays an important role in maintaining mucosal health. The role of mucosal microbial populations in the pathogenesis of gastrointestinal diseases has been well established in other species. However, limited information is available about changes in the fecal microbiota that occur under disease conditions, such as hemorrhagic diarrhea in feedlot cattle. The objectives of this study were to characterize the differences in fecal microbiota composition, diversity and functional gene profile between feedlot calves with, and without, hemorrhagic diarrhea...
December 21, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29273091/mesenchymal-stem-cells-decrease-lung-inflammation-during-sepsis-acting-through-inhibition-of-the-mapk-pathway
#11
Leonardo Pedrazza, Monica Cubillos-Rojas, Fernanda Cristina de Mesquita, Carolina Luft, Aline Andrea Cunha, Jose Luis Rosa, Jarbas Rodrigues de Oliveira
BACKGROUND: Sepsis is a severe medical condition that ranks among the top 10 causes of death worldwide and which has permanently high incidence rates. Mesenchymal stem cells (MSCs) have been found to be potent modulators of immune responses. More importantly, there is evidence that MSCs have a beneficial effect on preclinical models of polymicrobial sepsis. However, the changes caused by the MSCs in the effector cells of the host immune system remain unclear. METHODS: A mouse model of sepsis (male C57BL/6 mice) with three experimental groups was used for experiments in vivo: a control group, an untreated septic group, and a septic group treated with MSCs...
December 22, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29261091/association-of-enterococcus-spp-with-severe-combat-extremity-injury-intensive-care-and-polymicrobial-wound-infection
#12
Rae A Heitkamp, Ping Li, Katrin Mende, Samandra T Demons, David R Tribble, Stuart D Tyner
BACKGROUND: Combat-related extremity wound infections can complicate the recovery of injured military personnel. The Enterococcus genus contains both commensal and pathogenic bacteria found in many combat wounds. We describe the patient population susceptible to Enterococcus infection, the characteristics of Enterococcus spp. isolated from combat-related wounds, and the microbiological profile of Enterococcus-positive wounds. METHODS: Patient and culture data were obtained from the Trauma Infectious Disease Outcomes Study...
December 20, 2017: Surgical Infections
https://www.readbyqxmd.com/read/29258641/denture-stomatitis-causes-cures-and-prevention
#13
Victoria Elizabeth Hannah, Lindsay O'Donnell, Douglas Robertson, Gordon Ramage
Removable dentures are worn by 20% of the UK population and two thirds of these individuals have denture stomatitis. Poor oral hygiene is commonplace among this group, as is smoking and xerostomia, which also contribute to the development of denture stomatitis. A complex polymicrobial biofilm is able to proliferate on the surface of denture materials and matures to form visible denture plaque. This denture plaque biofilm stimulates a local inflammatory process that is detectable clinically as erythema, and hyperplasia...
December 1, 2017: Primary Dental Journal
https://www.readbyqxmd.com/read/29258263/tussilagone-inhibits-the-inflammatory-response-and-improves-survival-in-clp-induced-septic-mice
#14
Yun Kyu Kim, Myeong Gu Yeo, Bo Kang Oh, Ha Yeong Kim, Hun Ji Yang, Seung-Sik Cho, Minchan Gil, Kyung Jin Lee
Tussilagone, extracted from Tussilago farfara is an oriental medicine used for asthma and bronchitis. We investigated its mechanism of action, its inhibitory effects on lipopolysaccharide-induced inflammation in macrophages, and its impact on viability in a cecal ligation and puncture (CLP)-induced mouse model of sepsis. Tussilagone suppressed the expression of the inflammatory mediators, nitric oxide and prostaglandin E2, and the inflammatory cytokines, tumor necrosis factor-alpha (TNF-α) and high-mobility group box 1 (HMGB1), in lipopolysaccharide-stimulated RAW 264...
December 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29246480/treatment-of-infected-non-unions-of-the-femur-and-tibia-in-a-french-referral-center-for-complex-bone-and-joint-infections-outcomes-of-55-patients-after-2-to-11-years
#15
T Bauer, S Klouche, O Grimaud, A Lortat-Jacob, P Hardy
INTRODUCTION: An infected nonunion is a major complication following bone fracture. While bone union can be obtained in 70% to 100% of cases, treatment of osteomyelitis is less predictable, with reported healing rates ranging from 40% to 100%. The primary aim of this study was to assess the success rate of treating infected non-unions of the tibia and femur by a team specializing in complex bone and joint infections. MATERIAL AND METHODS: This single-center retrospective study included all patients operated between 2002 and 2012 due to an infected nonunion of the femur or tibia using standardized surgical methods...
December 12, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29245276/clinical-and-microbiological-characteristics-of-vancomycin-resistant-enterococcus-faecium-bloodstream-infection-in-central-taiwan
#16
Chang-Hua Chen, Li-Chen Lin, Yu-Jun Chang, Chih-Yen Chang
Bloodstream infections (BSIs) due to vancomycin-resistant Enterococcus faecium (VREfae) remain a therapeutic challenge. This study aimed to evaluate mortality from BSIs due to VREfae in Central Taiwan.We retrospectively analyzed patients with significant VREfae BSIs in the Changhua Christian Hospital System between January 1, 2010 and December 31, 2014.Of the 152 patients with Enterococcal BSI, 56 patients (36.8%) were admitted to intensive care units (ICUs) at the onset of BSI and 20 (13.2%) patients were associated with polymicrobial bacteremia...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29241843/quantifying-the-effect-of-diabetes-on-surgical-hand-and-forearm-infections
#17
Ketan Sharma, Deng Pan, James Friedman, Jenny L Yu, Aaron Mull, Amy M Moore
PURPOSE: Diabetes has long been established as a risk factor for hand and forearm infections. The purpose of this study was to review the effect of glycemic factors on outcomes among diabetic patients with surgical upper-extremity infections. We hypothesized that diabetic inpatients may benefit from stronger peri-infection glycemic control. METHODS: A prospective cohort study enrolled diabetic and nondiabetic surgical hand and forearm infections over 3 years. Glycemic factors included baseline glycosylated hemoglobin, blood glucose (BG) at presentation, and inpatient BG...
December 11, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29233035/from-the-wound-to-the-bench-exoproteome-interplay-between-wound-colonizing-staphylococcus-aureus-strains-and-co-existing-bacteria
#18
Andrea N García-Pérez, Anne de Jong, Sabryna Junker, Dörte Becher, Monika A Chlebowicz, José C Duipmans, Marcel F Jonkman, Jan Maarten van Dijl
Wound-colonizing microorganisms can form complex and dynamic polymicrobial communities where pathogens and commensals may co-exist, cooperate or compete with each other. The present study was aimed at identifying possible interactions between different bacteria isolated from the same chronic wound of a patient with the genetic blistering disease epidermolysis bullosa (EB). Specifically, this involved two different isolates of the human pathogen Staphylococcus aureus, and isolates of Bacillus thuringiensis and Klebsiella oxytoca...
December 13, 2017: Virulence
https://www.readbyqxmd.com/read/29232699/cxcr4-blockade-decreases-cd4-t-cell-exhaustion-and-improves-survival-in-a-murine-model-of-polymicrobial-sepsis
#19
Kimberly M Ramonell, Wenxiao Zhang, Annette Hadley, Ching-Wen Chen, Katherine T Fay, John D Lyons, Nathan J Klingensmith, Kevin W McConnell, Craig M Coopersmith, Mandy L Ford
Sepsis is a dysregulated systemic response to infection involving many inflammatory pathways and the induction of counter-regulatory anti-inflammatory processes that results in a state of immune incompetence and can lead to multi-organ failure. CXCR4 is a chemokine receptor that, following ligation by CXCL12, directs cells to bone marrow niches and also plays an important role in T cell cosignaling and formation of the immunological synapse. Here, we investigated the expression and function of CXCR4 in a murine model of polymicrobial sepsis...
2017: PloS One
https://www.readbyqxmd.com/read/29232563/immunologic-burden-links-periodontitis-to-acute-coronary-syndrome
#20
John M Liljestrand, Susanna Paju, Milla Pietiäinen, Kåre Buhlin, G Rutger Persson, Markku S Nieminen, Juha Sinisalo, Päivi Mäntylä, Pirkko J Pussinen
BACKGROUND AND AIMS: Periodontitis, a common polymicrobial inflammatory disease in the tooth supporting tissues, is a risk factor for coronary artery disease. One of the proposed underlying mechanisms is the systemic immune response to periodontal infection. We studied how serum antibodies against seven periodontal pathogens and their subgingival levels associate with each other, periodontitis, and coronary artery disease. METHODS: The Parogene cohort included 505 Finnish patients (mean age 63 y) who underwent coronary angiography, and clinical and radiographic oral examinations...
January 2018: Atherosclerosis
keyword
keyword
30948
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"