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https://www.readbyqxmd.com/read/28343672/effect-of-titanium-and-zirconia-dental-implant-abutments-on-a-cultivable-polymicrobial-saliva-community
#1
Erica D de Avila, Carlos Eduardo Vergani, Francisco A Mollo Junior, Miguel Jafelicci Junior, Wenyuan Shi, Renate Lux
STATEMENT OF PROBLEM: Periimplantitis is considered the most important biological complication responsible for late implant failure. The physical chemical properties intrinsic to each material can affect the first step to biofilm development and is an important precursor to the adaptive behavior of pathogenic bacteria species. PURPOSE: The purpose of this in vitro study was to evaluate the effect of 2 commercially available implant abutment materials on the adhesion phase and biofilm formation...
March 23, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28341068/clinical-characteristics-of-pyogenic-flexor-tenosynovitis-in-pediatric-patients
#2
Christopher M Brusalis, Stephanie Thibaudeau, Robert B Carrigan, Ines C Lin, Benjamin Chang, Apurva S Shah
PURPOSE: To characterize the clinical presentation, common pathogens, antimicrobial susceptibility, and treatment methods associated with pyogenic flexor tenosynovitis (PFT) in pediatric patients. METHODS: Patients who underwent surgical treatment for PFT at a large tertiary-care children's hospital between 2001 and 2015 were identified. Descriptive summary statistics were reported on patient demographics, presenting symptoms and clinical examination features, culture results, treatment strategies, and early complications...
March 21, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28336238/hydropneumothorax-due-to-esophageal-rupture
#3
Joseph R Shiber, Emily Fontane, Jin H Ra, Andrew J Kerwin
BACKGROUND: A brief review of the historical aspects of esophageal rupture is presented along with a case and current recommendations for diagnostic evaluation and treatment. CASE REPORT: A 97-year-old woman complained of acute dyspnea without prior vomiting. Chest x-ray study showed a large right pneumothorax with associated effusion. A thoracostomy tube was placed with return of > 1 L turbid fluid with polymicrobial culture and elevated pleural fluid amylase level...
March 20, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28335962/combining-anova-pca-with-pochemon-to-analyse-micro-organism-development-in-a-polymicrobial-environment
#4
Brigitte P Geurts, Anne H Neerincx, Samuel Bertrand, Manja A A P Leemans, Geert J Postma, Jean-Luc Wolfender, Simona M Cristescu, Lutgarde M C Buydens, Jeroen J Jansen
Revealing the biochemistry associated to micro-organismal interspecies interactions is highly relevant for many purposes. Each pathogen has a characteristic metabolic fingerprint that allows identification based on their unique multivariate biochemistry. When pathogen species come into mutual contact, their co-culture will display a chemistry that may be attributed both to mixing of the characteristic chemistries of the mono-cultures and to competition between the pathogens. Therefore, investigating pathogen development in a polymicrobial environment requires dedicated chemometric methods to untangle and focus upon these sources of variation...
April 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28328294/microbiological-characteristics-and-clinical-outcomes-of-acinetobacter-spp-endophthalmitis-with-the-first-reported-case-of-acinetobacter-haemolyticus-endophthalmitis
#5
Mahima Jhingan, Divya Balakrishnan, Padmaja Kumari Rani, Mudit Tyagi, Joveeta Joseph
AIM: To present the microbiological details and clinical outcomes of Acinetobacter spp. endophthalmitis with the first reported case of A. haemolyticus. METHODS: A retrospective study of microbiologically proven Acinetobacter spp. endophthalmitis was carried out from 2010 to 2015. The data collected included age, type of endophthalmitis, best-corrected visual acuity (BCVA), species involved, and antibiotic susceptibility pattern. The primary outcomes measured were anatomical outcomes in terms of globe integrity and functional outcome as BCVA at last follow-up...
March 22, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28326980/gene-sequence-analyses-of-the-healthy-oral-microbiome-in-humans-and-companion-animals
#6
Eric M Davis
It has long been accepted that certain oral bacterial species are responsible for the development of periodontal disease. However, the focus of microbial and immunological research is shifting from studying the organisms associated with disease to examining the indigenous microbial inhabitants that are present in health. Microbiome refers to the aggregate genetic material of all microorganisms living in, or on, a defined habitat. Recent developments in gene sequence analysis have enabled detection and identification of bacteria from polymicrobial samples, including subgingival plaque...
June 2016: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28323195/left-ventricular-assist-device-related-infections-a-multicentric-study
#7
S Siméon, E Flécher, M Revest, M Niculescu, J-C Roussel, M Michel, P Leprince, P Tattevin
OBJECTIVES: Implantable left ventricular assist device (LVAD) is a major therapeutic progress for end-stage heart failure in selected patients. As their use is expanding, infectious complications are emerging, with limited data available to guide their management. We aimed to better characterize LVAD-related infections. METHODS: We enrolled all consecutive patients diagnosed with LVAD-related infections in 3 referral centers in France, using standardized definition of infections in patients with LVAD...
March 18, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28322834/anti-human-cd14-monoclonal-antibody-improves-survival-following-sepsis-induced-by-endotoxin-but-not-following-polymicrobial-infection
#8
Masaki Nakamura, Takashi Takeuchi, Kamon Shirakawa, Shoji Furusako
Cluster of differentiation 14 (CD14), a pattern recognition receptor expressed on myeloid cells and a critical component of the innate immune system, mediates local and systemic host responses to gram-negative bacterial products, including lipopolysaccharide (LPS). Therefore, CD14 is an attractive target for development of sepsis therapies, and several monoclonal anti-CD14 antibodies have been reported. In this study, we prepared an anti-human CD14 monoclonal antibody, F1024-1-3, which suppressed LPS-induced upregulation of pro-inflammatory cytokines and an adhesion molecule in human peripheral mononuclear cells and human vascular endothelial cells...
March 16, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28321823/cardiovascular-disease-and-resuscitated-septic-shock-lead-to-the-downregulation-of-the-h2s-producing-enzyme-cystathionine-%C3%AE-lyase-in-the-porcine-coronary-artery
#9
Tamara Merz, Tatjana Stenzel, Benedikt Nußbaum, Martin Wepler, Csaba Szabo, Rui Wang, Peter Radermacher, Oscar McCook
BACKGROUND: Downregulation of the hydrogen sulfide (H2S)-producing enzymes cystathionine-γ-lyase (CSE), cystathionine-β-synthase (CBS), and/or 3-mercaptopyruvate sulfurtransferase (3-MST) is associated with chronic cardiovascular pathologies. Nevertheless, equivocal data are available on both the expression and function of these enzymes in coronary arteries (CA). We recently reported that atherosclerotic pigs subjected to sepsis developed impaired cardiac function, which coincided with decreased myocardial CSE expression and increased nitrotyrosine formation...
December 2017: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/28317564/odontogenic-infections
#10
REVIEW
Orrett E Ogle
The pathogenesis of odontogenic infection is polymicrobial, consisting of various facultative and strict anaerobes. The dominant isolates are strictly anaerobic gram-negative rods and gram-positive cocci. The periapical infection is the most common form of odontogenic infection. Although odontogenic infections are usually confined to the alveolar ridge vicinity, they can spread into deep fascial spaces. Cavernous sinus thrombosis, brain abscess, airway obstruction, and mediastinitis are possible complications of dental infections...
April 2017: Dental Clinics of North America
https://www.readbyqxmd.com/read/28304248/sustained-release-buprenorphine-improves-postsurgical-clinical-condition-but-does-not-alter-survival-or-cytokine-levels-in-a-murine-model-of-polymicrobial-sepsis
#11
Nicole L Herndon, Sheila Bandyopadhyay, Eldad A Hod, Kevin A Prestia
Cecal ligation and perforation (CLP) is a common technique for studying sepsis in mice. Because of the invasiveness of the procedure and its effects on clinical condition, many animal care and use committees require the use of analgesics with CLP. However, some analgesics have immunomodulatory effects and thus can hinder the overall research outcomes of a project. Here we sought to determine the effects of buprenorphine hydrochloride (Bup HCl) compared with sustained-release buprenorphine (Bup SR) on clinical condition, plasma concentrations of monocyte chemoattractant protein (MCP) 1 and IL6, and overall mortality in a murine CLP model of sepsis...
December 1, 2016: Comparative Medicine
https://www.readbyqxmd.com/read/28303956/inhibitory-role-of-acyl-homoserine-lactones-in-hemolytic-activity-and-viability-of-streptococcus-pyogenes-m6-s165
#12
Sunil D Saroj, Linda Holmer, Júlia M Berengueras, Ann-Beth Jonsson
Streptococcus pyogenes an adapted human pathogen asymptomatically colonizes the nasopharynx, among other polymicrobial communities. However, information on the events leading to the colonization and expression of virulence markers subject to interspecies and host-bacteria interactions are limited. The interference of acyl homoserine lactones (AHLs) with the hemolytic activity and viability of S. pyogenes M6 S165 was examined. AHLs, with fatty acid side chains ≥12 carbon atoms, inhibited hemolytic activity by downregulating the expression of the sag operon involved in the production of streptolysin S...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28301571/modulation-of-behaviour-and-virulence-of-a-high-alginate-expressing-pseudomonas-aeruginosa-strain-from-cystic-fibrosis-by-oral-commensal-bacterium-streptococcus-anginosus
#13
Richard D Waite, Muhammad R Qureshi, Robert A Whiley
Cystic fibrosis (CF) airways harbour complex and dynamic polymicrobial communities that include many oral bacteria. Despite increased knowledge of CF airway microbiomes the interaction between established CF pathogens and other resident microbes and resulting impact on disease progression is poorly understood. Previous studies have demonstrated that oral commensal streptococci of the Anginosus group (AGS) can establish chronic pulmonary infections and become numerically dominant in CF sputa indicating that they play an important role in CF microbiome dynamics...
2017: PloS One
https://www.readbyqxmd.com/read/28293219/insights-into-dynamic-polymicrobial-synergy-revealed-by-time-coursed-rna-seq
#14
Erik L Hendrickson, David A C Beck, Daniel P Miller, Qian Wang, Marvin Whiteley, Richard J Lamont, Murray Hackett
Many bacterial infections involve polymicrobial communities in which constituent organisms are synergistically pathogenic. Periodontitis, a commonly occurring chronic inflammatory disorder, is induced by multispecies bacterial communities. The periodontal keystone pathogen Porphyromonas gingivalis and the accessory pathogen Streptococcus gordonii exhibit polymicrobial synergy in animal models of disease. Mechanisms of co-adhesion and community formation by P. gingivalis and S. gordonii are well-established; however, little is known regarding the basis for increased pathogenicity...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28289498/intracardiac-fungal-mass-in-a-term-neonate
#15
Magdy M El-Sayed Ahmed, Mustafa Kurkluoglu, Conor F Hynes, Darren Klugman, Elena Puscasiu, Dilip S Nath
Systemic fungal infections pose insidious challenges in neonatal intensive care settings. We present the case of a 9-day-old male term neonate admitted for polymicrobial sepsis and hepatic dysfunction who later developed candidemia superinfection. Despite broad antifungal therapy, the fungemia was complicated by progressive growth of a fungus ball in the right ventricular outflow tract that threatened cardiac function. Surgical excision of the mass was undertaken by right atriotomy and histologic examination confirmed Candida albicans...
October 2016: Methodist DeBakey Cardiovascular Journal
https://www.readbyqxmd.com/read/28289087/reoxidation-of-the-thiol-disulfide-oxidoreductase-mdba-by-a-bacterial-vitamin-k-epoxide-reductase-in-the-biofilm-forming-actinobacterium-actinomyces-oris
#16
Truc Thanh Luong, Melissa E Reardon-Robinson, Sara D Siegel, Hung Ton-That
Post-translocational protein folding in the Gram-positive biofilm-forming actinobacterium Actinomyces oris is mediated by a membrane-bound thiol-disulfide oxidoreductase named MdbA, which catalyzes oxidative folding of nascent polypeptides transported by the Sec translocon. Reoxidation of MdbA involves a bacterial Vitamin K Epoxide Reductase (VKOR)-like protein that contains four cysteine residues C93/C101 and C175/C178 with the latter forming a canonical CXXC thioredoxin-like motif; however, the mechanism of VKOR-mediated reoxidation of MdbA is not known...
March 13, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28287302/cutaneous-wound-biofilm-and-the-potential-for-electrical-stimulation-in-management-of-the-microbiome
#17
Mohammed Ashrafi, Mohamed Baguneid, Teresa Alonso-Rasgado, Riina Rautemaa-Richardson, Ardeshir Bayat
Infection contributes significantly to delayed cutaneous wound healing, which impacts patient care. External application of electrical stimulation (ES) has beneficial effects on wound repair and regeneration. The majority of studies to date have explored ES in relation to planktonic microorganisms, yet evidence indicates that bacteria in chronic wounds reside as antibiotic-resistant polymicrobial biofilms, which contribute to impairing wound healing. Culture-independent sequencing techniques have revolutionized our understanding of the skin microbiome and allowed a more accurate determination of microbial taxa and their relative abundance in wounds allowing a greater understanding of the host-microbial interface...
March 2017: Future Microbiology
https://www.readbyqxmd.com/read/28286023/peritoneal-infection-due-to-peptoniphilus-harei-in-a-patient-with-intestinal-occlusion
#18
Fernando Cobo, Javier Rodríguez-Granger, Antonio Sampedro, José María Navarro-Marí
Peptoniphilus harei is a Gram-positive anaerobic coccus mainly involved in polymicrobial infections. We report a case of peritoneal infection in a patient with intestinal occlusion. A 48-year-old woman presented with ascitis after an occlusive syndrome. Culture of peritoneal fluid resulted on P. harei isolation. Treatment was performed and resolution of this infection was documented.
March 7, 2017: Anaerobe
https://www.readbyqxmd.com/read/28285096/periprosthetic-joint-infection-by-propionibacterium-acnes-clinical-differences-between-monomicrobial-versus-polymicrobial-infection
#19
Raúl Figa, David Muñetón, Lucía Gómez, A Matamala, Mayli Lung, Eva Cuchi, Pablo S Corona
OBJECTIVE: To compare a series of monomicrobial Propionibacterium acnes (P. acnes) knee and hip periprosthetic joint infection (PJI) cases with cases of polymicrobial PJI which included P. acnes. We hypothesized that the presence of a polymicrobial P. acnes infection would lead to worse outcomes than those in cases of monomicrobial P. acnes PJI. METHODS: Retrospective multicentre study. All patients with hip or knee PJIs including P. acnes diagnosed from August-2002 to July-2013 in two university hospitals were included...
March 8, 2017: Anaerobe
https://www.readbyqxmd.com/read/28284339/inhibition-of-indoleamine-2-3-dioxygenase-1-2-prevented-cognitive-impairment-and-energetic-metabolism-changes-in-the-hippocampus-of-adult-rats-subjected-to-polymicrobial-sepsis
#20
Clarissa M Comim, Viviane Freiberger, Letícia Ventura, Francielle Mina, Gabriela K Ferreira, Monique Michels, Jaqueline S Generoso, Emílio L Streck, João Quevedo, Tatiana Barichello, Felipe Dal-Pizzol
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection that may affect the brain. We investigated the role of indoleamine 2,3-dioxygenase (IDO-1/2) inhibition on long-term memory and energetic metabolism after experimental sepsis by caecal ligation and perforation (CLP). Experimental sepsis increased the activity of complexes I, II-III and IV at 24h after CLP, and IDO-1/2 inhibition normalized the activity of these complexes in the hippocampus. Wistar rats presented impairment of habituation and aversive memories 10days after CLP...
April 15, 2017: Journal of Neuroimmunology
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