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https://www.readbyqxmd.com/read/28723852/effects-of-a-skin-barrier-cream-on-management-of-incontinence-associated-dermatitis-in-older-women-a-cluster-randomized-controlled-trial
#1
Yuka Kon, Yoshie Ichikawa-Shigeta, Terumi Iuchi, Yukari Nakajima, Gojiro Nakagami, Keiko Tabata, Hiromi Sanada, Junko Sugama
PURPOSE: The purpose of this study was to examine the effects of a skin barrier cream with moisturization and skin-protectant characteristics for improving the severity of incontinence-associated dermatitis (IAD) pertaining to the skin physiology and appearance. We measured the following outcomes: (1) skin physiological characteristics indicating skin protection and enhancement of the skin's moisture barrier (stratum corneum hydration, dermis hydration level, transepidermal water loss, and skin pH); and (2) changes in skin appearance (the degree of erythema and pigmentation, and the sulcus cutis condition)...
July 18, 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/28712539/chronic-treatment-with-angiotensin-converting-enzyme-inhibitor-increases-cardiac-fibrosis-in-young-rats-submitted-to-early-ovarian-failure
#2
Sabrina Graziani Veloso Dutra, Ana Carolina Sanches Felix, Ada Clarice Gastaldi, Tábata De Paula Facioli, Suenimeire Vieira, Hugo Celso Dutra De Souza
BACKGROUND: We investigated whether the treatment with enalapril maleate, combined with aerobic physical training, promotes positive effects on the autonomic balance, the morphology and the cardiac function in female rats submitted to early ovarian failure. METHODS: Thirty-five female Wistar rats, ovariectomized at 10weeks of age, were assigned into Ovariectomized rats (OVX) and Ovariectomized rats treated with enalapril maleate (OVX-EM, 10mg(-1)·kg(-1)·d(-1)) Each group was subdivided into sedentary and trained (aerobic swimming training for 10weeks)...
July 10, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28710515/quantitative-lc-esi-srm-ms-of-antibody-biopharmaceuticals-use-of-a-homologous-antibody-as-an-internal-standard-and-three-step-method-development
#3
Fumio Osaki, Kenji Tabata, Tomoyuki Oe
Monoclonal antibody-based therapeutic agents (antibody drugs) have attracted considerable attention as a new type of drug. Concomitantly, the use of quantitative approaches for characterizing antibody drugs, such as liquid chromatography (LC)-mass spectrometry (MS), has increased. Generally, selective quantification of antibody drugs is done using unique peptides from variable regions (V H and V L) as surrogate peptides. Further, numerous internal standards (ISs) such as stable isotope-labeled (SIL)-intact proteins and SIL-surrogate peptides are used...
July 14, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28710182/elevation-of-b-type-natriuretic-peptide-at-discharge-is-associated-with-2-year-mortality-after-transcatheter-aortic-valve-replacement-in-patients-with-severe-aortic-stenosis-insights-from-a-multicenter-prospective-ocean-tavi-optimized-transcatheter-valvular
#4
Kazuki Mizutani, Masahiko Hara, Shinichi Iwata, Takashi Murakami, Toshihiko Shibata, Minoru Yoshiyama, Toru Naganuma, Futoshi Yamanaka, Akihiro Higashimori, Norio Tada, Kensuke Takagi, Motoharu Araki, Hiroshi Ueno, Minoru Tabata, Shinichi Shirai, Yusuke Watanabe, Masanori Yamamoto, Kentaro Hayashida
BACKGROUND: In this study, we sought to investigate the 2-year prognostic impact of B-type natriuretic peptide (BNP) levels at discharge, following transcatheter aortic valve replacement. METHODS AND RESULTS: We enrolled 1094 consecutive patients who underwent transcatheter aortic valve replacement between 2013 and 2016. Study patients were stratified into 2 groups according to survival classification and regression tree analysis (high versus low BNP groups). We evaluated the impact of high BNP on 2-year mortality compared with that of low BNP using a multivariable Cox model, and assessed whether this stratification would improve predictive accuracy for determining 2-year mortality by assessing time-dependent net reclassification improvement and integrated discrimination improvement...
July 14, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28699196/cytokeratin-positive-folliculo-stellate-cells-in-chicken-adenohypophysis
#5
Shotaro Nishimura, Miyu Yamashita, Takane Kaneko, Fuminori Kawabata, Shoji Tabata
Folliculo-stellate (FS) cells are non-endocrine cells found in the adenohypophysis and are identified in many animals by the S100 protein marker. Although keratin is another FS marker in several animals, there is no information on localization of keratin in the avian adenohypophysis. In this study, localization of cytokeratin in chicken adenohypophyseal cells was investigated immunohistochemically. Basic cytokeratin (bCK)-positive cells were arranged radially in the cell cords with their cytoplasmic processes reaching the basal lamina...
July 12, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28697739/effects-of-transcutaneous-electrical-nerve-stimulation-tens-on-proinflammatory-cytokines-protocol-for-systematic-review
#6
Tábata Cristina do Carmo Almeida, Francisco Winter Dos Santos Figueiredo, Valter Cordeiro Barbosa Filho, Luiz Carlos de Abreu, Fernando Luiz Affonso Fonseca, Fernando Adami
BACKGROUND: Pain reduction can be achieved by lowering proinflammatory cytokine levels in the blood. Transcutaneous electrical nerve stimulation (TENS) is a non-invasive physiotherapeutic resource for pain management, but evidence on the effectiveness of this device at reducing proinflammatory cytokines in the blood is unclear. This study systematically reviews the literature on the effect of TENS on proinflammatory cytokines. METHODS: A systematic review protocol was developed based on searches of articles in six electronic databases and references of retrieved articles, contact with authors, and repositories of clinical trials...
July 11, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28674269/detection-of-ceramide-a-risk-factor-for-coronary-artery-disease-in-human-coronary-plaques-by-fluorescent-angioscopy
#7
Yasumi Uchida, Yasuto Uchida, Takanobu Kobayashi, Seiichiro Shirai, Nobuyuki Hiruta, Ei Shimoyama, Tsuyoshi Tabata
BACKGROUND: The presence of ceramide in human coronary plaques is a risk factor for ischemic heart disease, but its visualization in the human vessel wall is currently beyond the scope of any available imaging techniques.Methods and Results:Deposition of ceramide was examined by fluorescent angioscopy (FA) and microscopy (FM) using golden fluorescence (Go) as a specific marker of ceramide in yellow plaques, which were obtained from 23 autopsy subjects and classified by conventional angioscopy and histology...
June 30, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28669848/isolated-brain-metastases-as-the-first-relapse-after-the-curative-surgical-resection-in-non-small-cell-lung-cancer-patients-with-an-egfr-mutation
#8
Shinko Sadoyama, Akimasa Sekine, Hiroaki Satoh, Tae Iwasawa, Terufumi Kato, Satoshi Ikeda, Masafumi Sata, Tomohisa Baba, Erina Tabata, Yuko Minami, Kenji Nemoto, Kenji Hayashihara, Takefumi Saito, Koji Okudela, Kenichi Ohashi, Michihiko Tajiri, Takashi Ogura
INTRODUCTION: The aim of this study was to clarify the incidence and disease behavior of brain metastases (BM) without extracranial disease (ie, isolated BM) as the first relapse after curative surgery in non-small-cell lung cancer (NSCLC) patients, analyzed according to epidermal growth factor receptor (EGFR) mutation status. PATIENTS AND METHODS: A review of the medical charts of consecutive NSCLC patients diagnosed between 2005 and 2016 with BM as the first relapse after curative surgery was performed...
June 1, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28668672/amiodarone-and-itraconazole-improve-the-activity-of-pentavalent-antimonial-in-the-treatment-of-experimental-cutaneous-leishmaniasis
#9
Laís Anversa, Monique Gomes Salles Tiburcio, Lara Rocha Batista, Marília Beatriz Cuba, Gabriel Antonio Nogueira Nascentes, Tábata Yamasaki Martins, Virgínia Bodelão Richini Pereira, Luciana da Silva Ruiz Menezes, Valdo José Dias da Silva, Luis Eduardo Ramirez
Leishmaniasis affect millions of people, causing morbidity and mortality, especially in developing tropical and subtropical countries. Unfortunately, the possibilities of treatment for these infections are still quite limited and most of the available drugs present serious side effects. The objective of this paper was to evaluate the therapeutic role of amiodarone and itraconazole in the treatment of cutaneous leishmaniasis caused by Leishmania (Leishmania) amazonensis. In order to perform this evaluation, hamsters were infected with 1 x 10(6) metaciclic promastigotes of the parasite in the hind footpad and, after the onset of the lesions, were treated with glucantime, amiodarone, itraconazole, glucantime and amiodarone, glucantime and itraconazole or amiodarone and itraconazole...
June 28, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28668313/in-stent-catheter-induced-neointimal-dissection-assessed-by-optical-coherence%C3%A2-tomography
#10
Kenta Ohmure, Satoshi Yoshino, Daichi Fukumoto, Hirokazu Shimono, Hiroyuki Tabata, Yoshihiro Uchikado, Shigeki Tateishi, Mitsuru Ohishi
No abstract text is available yet for this article.
June 21, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28663499/decoding-of-position-in-the-developing-neural-tube-from-antiparallel-morphogen-gradients
#11
Marcin Zagorski, Yoji Tabata, Nathalie Brandenberg, Matthias P Lutolf, Gašper Tkačik, Tobias Bollenbach, James Briscoe, Anna Kicheva
Like many developing tissues, the vertebrate neural tube is patterned by antiparallel morphogen gradients. To understand how these inputs are interpreted, we measured morphogen signaling and target gene expression in mouse embryos and chick ex vivo assays. From these data, we derived and validated a characteristic decoding map that relates morphogen input to the positional identity of neural progenitors. Analysis of the observed responses indicates that the underlying interpretation strategy minimizes patterning errors in response to the joint input of noisy opposing gradients...
June 30, 2017: Science
https://www.readbyqxmd.com/read/28648299/the-intra-articular-injection-of-rankl-binding-peptides-inhibits-cartilage-degeneration-in-a-murine-model-of-osteoarthritis
#12
Md Zahirul Haque Bhuyan, Yukihiko Tamura, Eri Sone, Yuki Yoshinari, Chizuko Maeda, Mariko Takahashi, Yasuhiko Tabata, Ramachandran Murali, Yoshihiro Waki, Kazuhiro Aoki
We recently found that the receptor activator of NF-κB ligand (RANKL)-binding peptide, OP3-4 stimulated the differentiation of both chondrocytes and osteoblasts. OP3-4 is also shown to inhibit cartilage degeneration. To clarify whether the peptide can inhibit cartilage degeneration without stimulating bone formation, we first performed a proliferation assay using C3H10T1/2 (the murine mesenchymal stem cell line), which is the common origin of both chondrocytes and osteoblasts. The RANKL-binding peptides, OP3-4 and W9, promoted cellular proliferation at 24 and 48 h, respectively...
June 13, 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/28644805/development-of-real-time-three-dimensional-photoacoustic-imaging-system-employing-spherically-curved-array-transducer
#13
Ryo Nagaoka, Takuya Tabata Ryo Takagi, Shin Yoshizawa, Shin-Ichiro Umemura, Yoshifumi Saijo
Photoacoustic imaging is a promising imaging modality to visualize specific living tissues based on the light absorption coefficients without dyeing. In this study, a real-time PA imaging system with a tunable laser was newly developed with an originally designed spherically curved array transducer. Five different series of experiments were conducted to validate the PA measurement system. The peak frequency of the transducer response was 17.7 MHz, and a volume-imaging rate of 3D volume imaging was 10 - 20 volumes per second...
June 21, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28637949/comparative-analysis-of-allyl-isothiocyanate-aitc-induced-carbohydrate-oxidation-changes-via-trpv1-between-mice-and-chickens
#14
Fuminori Kawabata, Yuko Kawabata, Ruojun Liang, Shotaro Nishimura, Shoji Tabata
Postprandial hyperglycemia is a risk factor for cardiovascular diseases. It has been reported that intragastric administration of allyl isothiocyanate (AITC), which is one of the pungent ingredients of wasabi and horseradish but it is not included in hot chili pepper, increased carbohydrate oxidation and reduced postprandial increase of blood glucose via transient receptor potential vanilloid 1 (TRPV1)in mice. However, the action site of AITC on TRPV1 for increasing carbohydrate oxidation is unclear. Both mammalian and chicken TRPV1 (cTRPV1) are activated by heat and acid, but unlike its mammalian counterpart, cTRPV1 is only faintly activated by capsaicin...
2017: Biomedical Research
https://www.readbyqxmd.com/read/28634935/generation-of-induced-pluripotent-stem-cells-in-defined-three-dimensional-hydrogels
#15
Massimiliano Caiazzo, Yoji Tabata, Matthias Lutolf
Since the groundbreaking discovery of induced pluripotent stem cells (iPSCs) many research groups have attempted to improve the efficiency of the classical cell reprogramming process. Surprisingly, the contribution of the three-dimensional (3D) microenvironment to iPSC generation has been largely overlooked. Here we describe a protocol for the generation of iPSCs in defined poly(ethylene glycol) (PEG)-based hydrogels that, besides allowing higher reprogramming efficiency, are also a powerful tool to study the influence of biophysical parameters on iPSC generation...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28633912/life-cycle-assessment-and-life-cycle-costs-for-pre-disaster-waste-management-systems
#16
Yohei Wakabayashi, Tsai Peii, Tomohiro Tabata, Takashi Saeki
This study develops a method of environmental and economic evaluation of an integrated disaster waste management system that considers the spatial scale of removal, transport, and treatment of disaster waste. A case study was conducted on combustibles, which is a type of disaster waste derived from dwellings, in Mie Prefecture, Japan. First, we calculated the quantity and the spatial distribution of disaster waste derived from dwellings and tsunami debris produced as a result of a large-scale earthquake. The quantity of disaster waste was estimated as 7,178,000t with functioning flood-preventing facilities and 11,956,000t without functioning flood prevention facilities...
June 17, 2017: Waste Management
https://www.readbyqxmd.com/read/28616567/cyp2c19-variants-and-epoxyeicosatrienoic-acids-in-patients-with-microvascular-angina
#17
Tomonori Akasaka, Daisuke Sueta, Yuichiro Arima, Noriaki Tabata, Seiji Takashio, Yasuhiro Izumiya, Eiichiro Yamamoto, Kenichi Tsujita, Sunao Kojima, Koichi Kaikita, Ayami Kajiwara, Kazunori Morita, Kentaro Oniki, Junji Saruwatari, Kazuko Nakagawa, Seiji Hokimoto
BACKGROUND: Categorization as a cytochrome P450 (CYP) 2C19 poor metabolizer (PM) is reported to be an independent risk factor for cardiovascular disease. Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid by CYP2C19 epoxygenases and anti-inflammatory properties, especially in microvascular tissues. We examined the impact of CYP2C19 polymorphisms and EETs on the patients with microvascular angina (MVA) caused by coronary microvascular dysfunction. METHODS AND RESULTS: We examined CYP2C19 genotypes in patients with MVA (n = 81)...
June 2017: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/28616549/changes-in-the-risk-factors-for-coronary-spasm
#18
Masanobu Ishii, Koichi Kaikita, Koji Sato, Kenshi Yamanaga, Takashi Miyazaki, Tomonori Akasaka, Noriaki Tabata, Yuichiro Arima, Daisuke Sueta, Kenji Sakamoto, Eiichiro Yamamoto, Kenichi Tsujita, Megumi Yamamuro, Sunao Kojima, Hirofumi Soejima, Seiji Hokimoto, Kunihiko Matsui, Hisao Ogawa
No abstract text is available yet for this article.
September 2016: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/28607101/positive-and-negative-control-pathways-by-blood-components-for-intermedilysin-production-in-streptococcus-intermedius
#19
Toshifumi Tomoyasu, Takahiro Yamasaki, Shinya Chiba, Shingo Kusaka, Atsushi Tabata, Robert A Whiley, Hideaki Nagamune
Streptococcus intermedius is an opportunistic bacterial pathogen secreting a human-specific cytolysin called intermedilysin (ILY) as a major pathogenic factor. This bacterium can degrade glycans into monosaccharides using two glycosidases, multisubstrate glycosidase A (MsgA) and neuraminidase (NanA). Here, we detected a strong hemolytic activity mediated by ILY when Sintermedius PC574 was cultured in fetal bovine serum (FBS) as compared to the standard culture medium. FBS-cultured cells also showed higher MsgA and NanA activity although overproduction of ILY in FBS was undetectable in mutants nanA-null and msgA-null...
June 12, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28595225/-mitral-valve-repair-in-a-patient-with-two-aneurysms-of-the-mitral-valve-due-to-infective-endocarditis-report-of-a-case
#20
Maiko Tsuji, Dai Une, Atsushi Kurata, Mimiko Tabata, Takayoshi Matsuyama, Hiroshi Seki, Akiyo Uda, Tomonobu Beika
Echocardiography revealed 2 aneurysms in the mitral valve with mitral regurgitation and aortic regurgitation,in a 42-years-old man. He had had infective endocarditis due to Streptococcus 9 months before. A prolapse in the right coronary cusp without vegetation and 2 aneurysms in the anterior mitral leaflet were found intraoperatively. Aortic valve was replaced, and then mitral aneurysms were resected and repaired using his own pericardium. There has been almost no regurgitation or recurrence of infection over 3 years...
June 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
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