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https://www.readbyqxmd.com/read/29049375/intratumoral-heterogeneity-of-programmed-cell-death-ligand-1-expression-is-common-in-lung-cancer
#1
Sayuri Nakamura, Kentaro Hayashi, Yuki Imaoka, Yuka Kitamura, Yuko Akazawa, Kazuhiro Tabata, Ruben Groen, Tomoshi Tsuchiya, Naoya Yamasaki, Takeshi Nagayasu, Junya Fukuoka
Programmed cell death ligand-1 (PD-L1) expression may predict the response to both programmed cell death-1 and PD-L1 inhibitors in lung cancer. However, the extent of intratumoral heterogeneity of PD-L1 expression, which may cause false negative results, is largely unexplored. We aimed to assess the intratumoral heterogeneity of PD-L1 expression in surgically resected lung cancer specimens by applying a novel method of tissue microarray, namely Spiral Arrays, which enables us to observe the heterogeneity in spiral-shaped tissue cores...
2017: PloS One
https://www.readbyqxmd.com/read/29046459/hepatitis-c-virus-replication-depends-on-endosomal-cholesterol-homeostasis
#2
Ina Karen Stoeck, Ji-Young Lee, Keisuke Tabata, Inés Romero-Brey, David Paul, Philipp Schult, Volker Lohmann, Lars Kaderali, Ralf Bartenschlager
Similar to other positive-strand RNA viruses, hepatitis C virus (HCV) causes massive rearrangements of intracellular membranes, resulting in a membranous web (MW) composed of predominantly double membrane vesicles (DMVs), the presumed sites of RNA replication. DMVs are enriched for cholesterol, but mechanistic details on the source and recruitment of cholesterol to the viral replication organelle are only partially known. Here we focused on selected lipid transfer proteins implicated in direct lipid transfer at various endoplasmic reticulum (ER) - membrane contact sites...
October 18, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29045613/genome-structure-of-rosa-multiflora-a-wild-ancestor-of-cultivated-roses
#3
Noriko Nakamura, Hideki Hirakawa, Shusei Sato, Shungo Otagaki, Shogo Matsumoto, Satoshi Tabata, Yoshikazu Tanaka
The draft genome sequence of a wild rose (Rosa multiflora Thunb.) was determined using Illumina MiSeq and HiSeq platforms. The total length of the scaffolds was 739,637,845 bp, consisting of 83,189 scaffolds, which was close to the 711 Mbp length estimated by k-mer analysis. N50 length of the scaffolds was 90,830 bp, and extent of the longest was 1,133,259 bp. The average GC content of the scaffolds was 38.9%. After gene prediction, 67,380 candidates exhibiting sequence homology to known genes and domains were extracted, which included complete and partial gene structures...
October 16, 2017: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
https://www.readbyqxmd.com/read/29042308/abiraterone-followed-by-enzalutamide-versus-enzalutamide-followed-by-abiraterone-in-chemotherapy-naive-patients-with-metastatic-castration-resistant-prostate-cancer
#4
Nobuaki Matsubara, Yoko Yamada, Ken-Ichi Tabata, Takefumi Satoh, Naoto Kamiya, Hiroyoshi Suzuki, Takashi Kawahara, Hiroji Uemura, Akihiro Yano, Satoru Kawakami, Masafumi Otsuka, Satoshi Fukasawa
BACKGROUND: Abiraterone (AA) and enzalutamide (ENZA) are increasingly being used in chemotherapy-naive patients with metastatic castration-resistant prostate cancer owing to efficacy and favorable toxicity. However, the order in which they should be administered has not been determined. PATIENTS AND METHODS: We retrospectively reviewed the records of chemotherapy-naive patients with metastatic castration-resistant prostate cancer who had received sequential treatment with either AA followed by ENZA (AA-ENZA) or the converse (ENZA-AA)...
September 23, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29033426/fracture-of-a-colonic-self-expandable-metallic-stent-in-malignant-colonic-obstruction-a-case-report
#5
Akinari Takao, Taku Tabata, Koichi Koizumi, Go Kuwata, Satomi Shibata, Makiko Mori, Kazuro Chiba, Sawako Kuruma, Tomoko Onishi, Takashi Fujiwara, Terumi Kamisawa, Junko Fujiwara, Takeo Arakawa, Kumiko Momma, Tatsu Shimoyama, Keiichi Takahashi
Self-expandable metallic stents (SEMSs) are used for the management of malignant colorectal obstruction. A patient who underwent colonic uncovered SEMS insertion for extraluminal stenosis in the splenic flexure of the transverse colon due to advanced gastric cancer is herein reported. The patient presented with a fracture of the colonic SEMS 494 days after SEMS insertion. Although various complications of stenting have previously been reported, the details of fractures of colonic SEMSs have not yet been reported...
October 16, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29029192/paracoccidioidomycosis-associated-with-a-heterozygous-stat4-mutation-and-impaired-ifn-%C3%AE-immunity
#6
Lena F Schimke, James Hibbard, Ruben Martinez-Barricarte, Taj Ali Khan, Ricardo de Souza Cavalcante, Edgar Borges de Oliveira Junior, Tabata Takahashi França, Asif Iqbal, Guilherme Yamamoto, Christina Arslanian, Claudia Feriotti, Tania Alves da Costa, Jacinta Bustamante, Stéphanie Boisson-Dupuis, Jean-Laurent Casanova, José Alexandre Marzagao Barbuto, Mayana Zatz, Rinaldo Poncio Mendes, Vera Lucia Garcia Calich, Hans D Ochs, Troy R Torgerson, Otávio Cabral-Marques, Antonio Condino-Neto
Background: Mutations in genes affecting interferon (IFN)-γ immunity have contributed to understand the essential role of IFN-γ in the protection against intracellular pathogens. However, inborn errors in STAT4, which controls IL-12 responses, have not yet been reported. Objective: To determine the underlying genetic defect in a family with a history of paracoccidioidomycosis (PCM) disease. Methods: Genetic analysis was performed by whole-exome sequencing and sanger sequencing...
October 5, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29028796/bak1-is-involved-in-atralf1-induced-inhibition-of-root-cell-expansion
#7
Keini Dressano, Paulo H O Ceciliato, Aparecida L Silva, Juan Carlos Guerrero-Abad, Tábata Bergonci, Fausto Andrés Ortiz-Morea, Marco Bürger, Marcio C Silva-Filho, Daniel S Moura
The rapid alkalinization factor (RALF) peptide negatively regulates cell expansion, and an antagonistic relationship has been demonstrated between AtRALF1, a root-specific RALF isoform in Arabidopsis, and brassinosteroids (BRs). An evaluation of the response of BR signaling mutants to AtRALF1 revealed that BRI1-associated receptor kinase1 (bak1) mutants are insensitive to AtRALF1 root growth inhibition activity. BAK1 was essential for the induction of AtRALF1-responsive genes but showed no effect on the mobilization of Ca2+ and alkalinization responses...
October 13, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29021549/protease-resistance-of-porcine-acidic-mammalian-chitinase-under-gastrointestinal-conditions-implies-that-chitin-containing-organisms-can-be-sustainable-dietary-resources
#8
Eri Tabata, Akinori Kashimura, Satoshi Wakita, Misa Ohno, Masayoshi Sakaguchi, Yasusato Sugahara, Yasutada Imamura, Shiro Seki, Hitoshi Ueda, Vaclav Matoska, Peter O Bauer, Fumitaka Oyama
Chitin, a polymer of N-acetyl-D-glucosamine (GlcNAc), is a major structural component in chitin-containing organism including crustaceans, insects and fungi. Mammals express two chitinases, chitotriosidase (Chit1) and acidic mammalian chitinase (AMCase). Here, we report that pig AMCase is stable in the presence of other digestive proteases and functions as chitinolytic enzyme under the gastrointestinal conditions. Quantification of chitinases expression in pig tissues using quantitative real-time PCR showed that Chit1 mRNA was highly expressed in eyes, whereas the AMCase mRNA was predominantly expressed in stomach at even higher levels than the housekeeping genes...
October 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29021436/multiple-myeloma-presenting-with-autoimmune-autonomic-ganglionopathy
#9
Yoshiki Nakae, Mizuki Hyuga, Wataru Kishimoto, Akiko Fukunaga, Sumie Tabata, Yoshitomo Maesako, Nobuyoshi Arima, Yuta Terada, Kenichi Komatsu, Osamu Higuchi, Shunya Nakane
Autoimmune autonomic ganglionopathy is an autonomic disorder that occurs as a symptom of paraneoplastic neurological syndrome. To date, there have been no reports on multiple myeloma with autoimmune autonomic ganglionopathy. A 37-year-old Japanese woman suffered from orthostatic hypotension was diagnosed with multiple myeloma (IgG kappa type), and a serological examination revealed the presence of anti-ganglionic nicotinic acetylcholine receptor (anti-gAChR) antibodies. She was treated for multiple myeloma, as a result, the autonomic disturbance improved and her anti-gAChR antibody titer decreased to undetectable levels, despite the fact that she only achieved a partial remission of multiple myeloma...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28989012/in-vivo-transgene-expression-in-the-pancreas-by-the-intraductal-injection-of-naked-plasmid-dna
#10
Yuma Yamada, Mai Tabata, Jiro Abe, Masatoshi Nomura, Hideyoshi Harashima
Patients with type I diabetes, which is caused by the destruction of pancreatic islets, now require regular therapeutic injections of insulin. The use of transgene therapy represents an alternate and potent strategy for the treatment of type I diabetes. However, only a limited number of studies regarding in vivo gene delivery targeting the pancreas and islets have been reported. Here, we report on the possibility of in vivo transgene expression in the pancreas by the intraductal injection of naked plasmid DNA (pDNA)...
October 5, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28988762/a-series-of-novel-indazole-derivatives-of-sirt-1-activator-as-osteogenic-regulators
#11
Masakazu Atobe, Natsumi Yamakawa, Yasuhiro Wada, Tokuhito Goto, Masashi Kawanishi, Takeshi Ito, Makoto Saito, Masahiro Takeda, Takanori Tabata, Hirokazu Arai
A series of indazole derivatives were identified as Sirt 1 activators though high-throughput screening. Optimization of each substituent on the indazole ring led to the identification of compound 13. Compound 13 appeared to give the best Sirt 1 activity of the compounds tested and also showed osteogenesis activity in a cell assay. Sirt 1 activators are therefore potential candidates for the treatment of osteoporosis.
September 25, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28986069/accuracy-and-usefulness-of-aortic-annular-measurement-using-real-time-three-dimensional-transesophageal-echocardiography-comparison-with-direct-surgical-sizing
#12
Tomoko Nishi, Kentaro Shibayama, Minoru Tabata, Nahoko Kato, Masahiko Noguchi, Hiroshi Okumura, Yuji Kawano, Daisuke Nakatsuka, Kotaro Obunai, Yoshio Kobayashi, Hiroyuki Watanabe
BACKGROUND: There is a paucity of data that demonstrates a clinical impact of anatomical measurements of the aortic annulus by three-dimensional (3D) transesophageal echocardiography (TEE) on surgical aortic valve replacement (AVR). The aim of this study is to validate the accuracy of 3D TEE measurements compared with the direct intraoperative annular diameter and to investigate an impact of 3D TEE on a prediction of AVR with aortic annular enlargement (AAE). METHODS AND RESULTS: We retrospectively enrolled 61 patients who underwent both two-dimension (2D) and 3D TEE and transthoracic echocardiography (TTE) before AVR...
October 3, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28980740/whole-slide-imaging-at-primary-pathological-diagnosis-validation-of-whole-slide-imaging-based-primary-pathological-diagnosis-at-twelve-japanese-academic-institutes
#13
Kazuhiro Tabata, Ichiro Mori, Takeshi Sasaki, Tomoo Itoh, Taizo Shiraishi, Naoki Yoshimi, Ichiro Maeda, Oi Harada, Kiyomi Taniyama, Daiki Taniyama, Mika Watanabe, Yoshiki Mikami, Shuntaro Sato, Yukio Kashima, Shota Fujimura, Junya Fukuoka
Several reports have demonstrated the use of whole-slide imaging (WSI) for primary pathological diagnosis, but no such studies have been published from Asia. We retrospectively collected 1070 WSI specimens from 900 biopsies and small surgeries conducted in nine hospitals. Nine pathologists, who participated in this study, trained for the College of American Pathologists guidelines, reviewed the specimens and made diagnoses based on digitized, 20× or 40× optically magnified images with a WSI scanner. After a washout interval of over 2 weeks, the same observers reviewed conventional glass slides and diagnosed them by light microscopy...
October 5, 2017: Pathology International
https://www.readbyqxmd.com/read/28980441/endoscopic-surgery-in-japan-the-12th-national-survey-2012-2013-by-the-japan-society-for-endoscopic-surgery
#14
Toshio Bandoh, Norio Shiraishi, Yuichi Yamashita, Toshiro Terachi, Makoto Hashizume, Shigeo Akira, Toshiaki Morikawa, Yuko Kitagawa, Katsuhiko Yanaga, Shunsuke Endo, Kiyoshi Onishi, Shuji Takiguchi, Yasuhiro Tamaki, Toru Hasegawa, Hiromitsu Mimata, Minoru Tabata, Ryohei Yozu, Masafumi Inomata, Sumio Matsumoto, Seigo Kitano, Masahiko Watanabe
In Japan, the first endoscopic surgery, a laparoscopic cholecystectomy, was performed in 1990. Since then, operative procedures have been standardized, and the safety and usefulness of endoscopic surgery have been evaluated. With the acceptance of endoscopic surgery as less invasive than open surgery, the number of the endoscopic procedures continues to increase in all surgical domains. The Japan Society for Endoscopic Surgery (JSES) has had an important role in the development of endoscopic surgery in Japan...
October 4, 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/28978111/tbx2-subfamily-suppression-in-lung-cancer-pathogenesis-a-high-potential-marker-for-early-detection
#15
Athar A Khalil, Smruthy Sivakumar, Frances Anthony San Lucas, Tina McDowell, Wenhua Lang, Kazuhiro Tabata, Junya Fujimoto, Yasushi Yatabe, Avrum Spira, Paul Scheet, Georges Nemer, Humam Kadara
The TBX2 subfamily (TBXs 2, 3, 4 and 5) transactivates or represses genes involved in lung organogenesis. Yet TBX2 subfamily expression in pathogenesis of non-small cell lung cancer (NSCLC), the most common lung malignancy, remains elusive. We sought to probe the expression profile of the TBX2 subfamily in early phases of NSCLC. Expression of TBX2 subfamily was analyzed in datasets of pan-normal specimens as well as NSCLCs and normal lung tissues. TBX2 subfamily expression in matched normal lungs, premalignant hyperplasias and NSCLCs was profiled by transcriptome sequencing...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28972948/a-novel-method-to-induce-cartilage-regeneration-with-cubic-microcartilage
#16
Hitoshi Nishiwaki, Mitsugu Fujita, Makoto Yamauchi, Noritaka Isogai, Yasuhiko Tabata, Hirohisa Kusuhara
Cartilage tissue is characterized by its poor regenerative properties, and the clinical performance of cartilage grafts to replace cartilage defects has been unsatisfactory. Recently, cartilage regeneration with mature chondrocytes and stem cells has been developed and applied in clinical settings. However, there are challenges with the use of mature chondrocytes and stem cells for tissue regeneration, including the high costs associated with the standard stem cell isolation methods and the decreased cell viability due to cell manipulation...
October 4, 2017: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/28968504/elucidation-of-the-e-amide-preference-of-n-acyl-azoles
#17
Yuka Takahashi, Hirotaka Ikeda, Yuki Kanase, Kosho Makino, Hidetsugu Tabata, Tetsuta Oshitari, Satoshi Inagaki, Yuko Otani, Hideaki Natsugari, Hideyo Takahashi, Tomohiko Ohwada
The conformational properties of N-acyl azoles (imidazole, pyrazole, and triazole) were examined. The N-2',4',6'-trichlorobenzoyl azoles were stable in methanol at room temperature, and no hydrolyzed products were observed over 7 days in the presence of 5% trifluoroacetic acid or 5% triethylamine in CDCl3. The high stability may be explained by the double-bond amide character caused by the steric hindrance due to the ortho-substituents in the benzoyl group. While specific E-amide preferences were observed in N-acyl pyrazoles/triazoles, the amides of the imidazoles gave a mixture of E and Z...
October 17, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28960780/changes-in-the-breath-sound-spectrum-during-methacholine-inhalation-in-children-with-asthma
#18
Hideyuki Tabata, Mayumi Enseki, Mariko Nukaga, Kota Hirai, Shinichi Matsuda, Hiroyuki Furuya, Masahiko Kato, Hiroyuki Mochizuki
BACKGROUND AND OBJECTIVE: An effort-independent breath sound analysis is expected to be a safe and simple method for clinical assessment of changes in airway function. The effects of bronchoconstriction and bronchodilation on novel breath sound parameters in asthmatic children were investigated. METHODS: The study population included 49 children with atopic asthma (male = 33; mean age: 10.2 years). We evaluated breath sound parameters of the highest frequency of the power spectrum (HFp), frequency limiting 50% and 99% of the power spectrum (F50 and F99 ) and roll-off from 600 Hz to the HFp (Slope)...
September 27, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28954984/characteristics-of-medical-students-who-would-like-to-be-a-generalist-physician-and-contribute-to-remote-area-medicine
#19
Kenji Tani, Yoshihiro Okura, Ryo Tabata, Shino Yuasa, Shingo Kawaminami, Yoshinori Nakanishi, Keisuke Kawahito, Keisuke Inaba, Kaori Inaba, Teruyoshi Kageji, Hiroki Tanaka, Yoshihiro Suzuki, Harutaka Yamaguchi
We administered a questionnaire to 5(th) grade medical students to examine the effect of community-based clinical practice on their attitudes to remote area medicine and their course after the graduation. Data from 192 students were obtained. The intensity of students' attitudes was estimated by using visual analogue scale. The intensities of the interest and a sense of fulfillment in remote area medicine were significantly increased after the practice. A significantly lower level of the intensity to become a generalist than that to become a specialist was seen in the students with low intensity in a sense of fulfillment...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28951750/comparison-of-prostate-contours-between-conventional-stepping-transverse-imaging-and-twister-based-sagittal-imaging-in-permanent-interstitial-prostate-brachytherapy
#20
Shogo Kawakami, Hiromichi Ishiyama, Takefumi Satoh, Hideyasu Tsumura, Akane Sekiguchi, Kouji Takenaka, Ken-Ichi Tabata, Masatsugu Iwamura, Kazushige Hayakawa
PURPOSE: To compare prostate contours on conventional stepping transverse image acquisitions with those on twister-based sagittal image acquisitions. MATERIAL AND METHODS: Twenty prostate cancer patients who were planned to have permanent interstitial prostate brachytherapy were prospectively accrued. A transrectal ultrasonography probe was inserted, with the patient in lithotomy position. Transverse images were obtained with stepping movement of the transverse transducer...
August 2017: Journal of Contemporary Brachytherapy
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