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https://www.readbyqxmd.com/read/28089567/adipose-tissue-clk2-promotes-energy-expenditure-during-high-fat-diet-intermittent-fasting
#1
Maximilian Hatting, Amy K Rines, Chi Luo, Mitsuhisa Tabata, Kfir Sharabi, Jessica A Hall, Francisco Verdeguer, Christian Trautwein, Pere Puigserver
A promising approach to treating obesity is to increase diet-induced thermogenesis in brown adipose tissue (BAT), but the regulation of this process remains unclear. Here we find that CDC-like kinase 2 (CLK2) is expressed in BAT and upregulated upon refeeding. Mice lacking CLK2 in adipose tissue exhibit exacerbated obesity and decreased energy expenditure during high-fat diet intermittent fasting. Additionally, tissue oxygen consumption and protein levels of UCP1 are reduced in CLK2-deficient BAT. Phosphorylation of CREB, a transcriptional activator of UCP1, is markedly decreased in BAT cells lacking CLK2 due to enhanced CREB dephosphorylation...
January 11, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28065867/cloning-expression-purification-and-biophysical-analysis-of-two-putative-halogenases-from-the-glycopeptide-a47-934-gene-cluster-of-streptomyces-toyocaensis
#2
Tabata P Cardoso, Larissa A de Sá, Priscila Dos S Bury, Sair M Chavez-Pacheco, Marcio V B Dias
Glycopeptides are an important class of antibiotics used in the treatment of several infections, including those caused by methicillin resistant Staphylococcus aureus. Glycopeptides are biosynthesized by a Non Ribosomal Peptide Synthase (NRPS) and the resulting peptide precursors are decorated by several tailoring enzymes, such as halogenases and glycosyltransferases. These enzymes are important targets of protein engineering to produce new derivatives of known antibiotics. Herein we show the production of two putative halogenases, denominated StaI and StaK, involved in the biosynthesis of the glycopeptide A47,934 in Streptomyces toyocaensis NRRL 15,009...
January 5, 2017: Protein Expression and Purification
https://www.readbyqxmd.com/read/28065456/characterization-and-functional-expression-of-a-rubber-degradation-gene-of-a-nocardia-degrader-from-a-rubber-processing-factory
#3
Dao Viet Linh, Nguyen Lan Huong, Michiro Tabata, Shunsuke Imai, Sou Iijima, Daisuke Kasai, To Kim Anh, Masao Fukuda
A rubber-degrading bacterial consortium named H2DA was obtained from an enrichment culture with natural rubber latex and rubber-processing factory waste in Vietnam. Gel permeation chromatography analysis revealed that only the strain NVL3 degraded synthetic poly(cis-1,4-isoprene) into low-molecular-weight intermediates among the three strains found in the H2DA. The 16S-rRNA gene sequence of NVL3 showed the highest identity with that of Nocardia farcinica DSM 43665(T). NVL3 accumulated aldehyde intermediates from synthetic poly(cis-1,4-isoprene) on a rubber-overlay plate as indicated by Schiff's staining...
January 3, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/28058831/peptide-tethered-hydrogel-scaffold-promotes-recovery-from-spinal-cord-transection-via-synergism-with-mesenchymal-stem-cells
#4
Li-Ming Li, Min Han, Xinchi Jiang, Xianzhen Yin, Fu Chen, Tian-Yuan Zhang, Hao Ren, Jiwen Zhang, Zhong Chen, Tingjun Hou, HongWei Ouyang, Yasuhiko Tabata, Youqing Shen, Jian-Qing Gao
Spinal cord injury (SCI) is one of the most devastating injuries. Treatment strategies for SCI are required to overcome comprehensive issues. Implantation of biomaterial scaffolds and stem cells has been demonstrated to be promising strategies. However, a comprehensive recovery effect is difficult to achieve. In the comprehensive treatment process, the specific roles of the implanted scaffolds and of stem cells in combined strategy are usually neglected. In this study, a peptide-modified scaffold is developed based on hyaluronic acid and an adhesive peptide PPFLMLLKGSTR...
January 6, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28050024/principal-component-analysis-uncovers-cytomegalovirus-associated-nk-cell-activation-in-ph-leukemia-patients-treated-with-dasatinib
#5
K Ishiyama, T Kitawaki, N Sugimoto, T Sozu, N Anzai, M Okada, M Nohgawa, K Hatanaka, N Arima, T Ishikawa, S Tabata, T Onaka, S Oka, Y Nakabo, R Amakawa, M Matsui, T Moriguchi, A Takaori-Kondo, N Kadowaki
No abstract text is available yet for this article.
January 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28043809/physical-training-associated-with-enalapril-but-not-to-losartan-results-in-better-cardiovascular-autonomic-effects
#6
Karina Delgado Maida, Ada Clarice Gastaldi, Tabata de Paula Facioli, João Eduardo de Araújo, Hugo Celso Dutra de Souza
BACKGROUND: We investigated the cardiovascular autonomic effects of physical training associated with Enalapril or Losartan pharmacological treatments in spontaneously hypertensive rats (SHR). METHODS: SHRs, 18weeks of age (N=48) was assigned to either sedentary (N=24) and trained (N=24; aerobic training by swimming for 10wk). Each group was subdivided in 3 subgroups (N=8) vehicle (control); Enalapril (10mg·kg(-1)·d(-1)); and Losartan (5mg·kg(-1)·d(-1)). All animals received a 10-week treatment in drinking water...
December 24, 2016: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28038804/validation-of-the-high-mortality-rate-of-malnutrition-inflammation-atherosclerosis-syndrome-community-based-observational-study
#7
Daisuke Sueta, Seiji Hokimoto, Kenji Sakamoto, Tomonori Akasaka, Noriaki Tabata, Koichi Kaikita, Osamu Honda, Masahiro Naruse, Hisao Ogawa
BACKGROUND: Malnutrition-Inflammation-Atherosclerosis (MIA) factors significantly and independently affect life prognosis of hemodialysis (HD) patients. We re-evaluated Japanese data, which have progressed ahead from a community-based observational study. The present study was designed to assess the contribution of these MIA factors to the mortality rate of Japanese HD patients in a community of 1.8 million people over a 36-month follow-up period. METHODS AND RESULTS: A total of 5813 patients at 76 facilities were on maintenance HD in the Kumamoto Prefecture...
December 21, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28035713/evaluation-of-the-effectiveness-of-the-potent-bis-quaternary-ammonium-compound-4-4-%C3%AE-%C3%AF-hexametylenedithio-bis-1-octylpyridinium-bromide-4dtbp-6-8-on-pseudomonas-aeruginosa
#8
Keiji Murakami, Hiromichi Yumoto, Ayu Murakami, Takashi Amoh, Darija Viducic, Katsuhiko Hirota, Atsushi Tabata, Hideaki Nagamune, Hiroki Kourai, Takashi Matsuo, Yoichiro Miyake
AIMS: Quaternary ammonium compounds (QACs) including benzalkonium chloride (BAC) and cetylpyridinium chloride (CPC) are cationic surfactants and have been used widely as general disinfectants in the medical field because of their strong antibacterial effects and low cytotoxicity to human cells. 4,4'-(α,ω-hexametylenedithio) bis (1-octylpyridinium bromide) (4DTBP-6,8) is one of the potent bis-QACs synthesized to improve the antimicrobial activities of mono-QACs such as BAC. This study aimed to assess the effectiveness of 4DTBP-6,8 against Pseudomonas aeruginosa, a prevalent hospital pathogen...
December 30, 2016: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28027813/environmental-and-economic-evaluation-of-pre-disaster-plans-for-disaster-waste-management-case-study-of-minami-ise-japan
#9
Tomohiro Tabata, Yohei Wakabayashi, Peii Tsai, Takashi Saeki
Although it is important that disaster waste be demolished and removed as soon as possible after a natural disaster, it is also important that its treatment is environmentally friendly and economic. Local municipalities do not conduct environmental and economic feasibility studies of pre-disaster waste management; nevertheless, pre-disaster waste management is extremely important to promote treatment of waste after natural disasters. One of the reasons that they cannot conduct such evaluations is that the methods and inventory data required for the environmental and economic evaluation does not exist...
December 24, 2016: Waste Management
https://www.readbyqxmd.com/read/28008251/coating-with-spermine-pullulan-polymer-enhances-adenoviral-transduction-of-mesenchymal-stem-cells
#10
Li Wan, Xinglei Yao, Francesco Faiola, Bojun Liu, Tianyuan Zhang, Yasuhiko Tabata, Hiroyuki Mizuguchi, Shinsaku Nakagawa, Jian-Qing Gao, Robert Chunhua Zhao
Mesenchymal stem cells (MSCs) are adult stem cells with multilineage potential, which makes them attractive tools for regenerative medicine applications. Efficient gene transfer into MSCs is essential not only for basic research in developmental biology but also for therapeutic applications involving gene-modification in regenerative medicine. Adenovirus vectors (Advs) can efficiently and transiently introduce an exogenous gene into many cell types via their primary receptors, the coxsackievirus and adenovirus receptors, but not into MSCs, which are deficient in coxsackievirus and adenovirus receptors expression...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28003052/population-pharmacokinetic-pharmacodynamic-analysis-to-compare-the-effect-of-moxifloxacin-on-qt-interval-prolongation-between-healthy-korean-and-japanese-subjects
#11
Hyang-Ki Choi, Jin Ah Jung, Tomoe Fujita, Hideki Amano, Jong-Lyul Ghim, Dong-Hwan Lee, Kenichi Tabata, Il-Dae Song, Mika Maeda, Yuji Kumagai, Boaz Mendzelevski, Jae-Gook Shin
PURPOSE: The goal of this study was to evaluate the moxifloxacin-induced QT interval prolongation in healthy male and female Korean and Japanese volunteers to investigate interethnic differences. METHODS: This multicenter, randomized, double-blind, placebo-controlled, 2-way crossover study was conducted in healthy male and female Korean and Japanese volunteers. In each period, a single dose of moxifloxacin or placebo 400 mg was administered orally under fasting conditions...
December 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27993981/prdm16-is-critical-for-progression-of-the-multipolar-phase-during-neural-differentiation-of-the-developing-neocortex
#12
Mayuko Inoue, Ryota Iwai, Hidenori Tabata, Daijiro Konno, Mariko Komabayashi-Suzuki, Chisato Watanabe, Hiroko Iwanari, Yasuhiro Mochizuki, Takao Hamakubo, Fumio Matsuzaki, Koh-Ichi Nagata, Ken-Ichi Mizutani
The precise control of neuronal migration and morphological changes during differentiation is essential for neocortical development. We hypothesized that the transition of progenitors through progressive stages of differentiation involves dynamic changes in mitochondrial reactive oxygen species (mtROS) levels, depending on cell requirements. We found that progenitors had higher levels of mtROS, but that these levels were significantly decreased with differentiation. The Prdm16 gene was identified as a candidate modulator of mtROS using microarray analysis, and was specifically expressed by progenitors in the ventricular zone...
December 19, 2016: Development
https://www.readbyqxmd.com/read/27989998/phylogenetic-analysis-reveals-the-taxonomically-diverse-distribution-of-the-pseudomonas-putida-group
#13
Kenta Yonezuka, Jun Shimodaira, Michiro Tabata, Shoko Ohji, Akira Hosoyama, Daisuke Kasai, Atsushi Yamazoe, Nobuyuki Fujita, Takayuki Ezaki, Masao Fukuda
Pseudomonas putida is well-known for degradation activities for a variety of compounds and its infections have been reported. Thus, P. putida includes both clinical and nonclinical isolates. To date, no reports have examined the phylogenetic relationship between clinical and nonclinical isolates of the P. putida group. In this study, fifty-nine strains of P. putida group containing twenty-six clinical, and thirty-three nonclinical, isolates, were subjected to phylogenetic and taxonomic analyses based on 16S rRNA gene sequences and nine housekeeping gene sequences, including argS, dnaN, dnaQ, era, gltA, gyrB, ppnK, rpoB, and rpoD, to obtain insights into the diversity of species in this group...
December 17, 2016: Journal of General and Applied Microbiology
https://www.readbyqxmd.com/read/27988920/ip-10-is-elevated-in-virus-induced-acute-exacerbations-in-childhood-asthma
#14
Kazuo Suzuki, Masahiko Kato, Shinichi Matsuda, Mariko Nukaga, Mayumi Enseki, Hideyuki Tabata, Kota Hirai, Yoshiyuki Yamada, Kenichi Maruyama, Yasuhide Hayashi, Hiroyuki Mochizuki
OBJECTIVE: Viral infections and sensitization to aeroallergens are major factors in the exacerbation of asthma and its development during early childhood. However, the cytokine profiles and eosinophil activation status linked to the association between viral infections and sensitization to aeroallergens are incompletely understood. Here we investigated respiratory viruses, serum eosinophil cationic protein (ECP), and various cytokines/chemokines in acute exacerbation of childhood asthma...
December 20, 2016: Tokai Journal of Experimental and Clinical Medicine
https://www.readbyqxmd.com/read/27987164/plant-genome-database-japan-pgdbj
#15
Akihiro Nakaya, Hisako Ichihara, Erika Asamizu, Sachiko Shirasawa, Yasukazu Nakamura, Satoshi Tabata, Hideki Hirakawa
A portal website that integrates a variety of information related to genomes of model and crop plants from databases (DBs) and the literature was generated. This website, named the Plant Genome DataBase Japan (PGDBj, http://pgdbj. jp/en/ ), is comprised of three component DBs and a cross-search engine which provides a seamless search over their contents. One of the three component DBs is the Ortholog DB, which provides gene cluster information based on the amino acid sequence similarity. Over 1,000,000 amino acid sequences of 40 Viridiplantae species were collected from the public DNA DBs, and plant genome DBs such as TAIR and RAP-DB were subjected to reciprocal BLAST searches for clustering...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27942871/evidence-based-clinical-practice-guidelines-for-cholelithiasis-2016
#16
REVIEW
Susumu Tazuma, Michiaki Unno, Yoshinori Igarashi, Kazuo Inui, Kazuhisa Uchiyama, Masahiro Kai, Toshio Tsuyuguchi, Hiroyuki Maguchi, Toshiyuki Mori, Koji Yamaguchi, Shomei Ryozawa, Yuji Nimura, Naotaka Fujita, Keiichi Kubota, Junichi Shoda, Masami Tabata, Tetsuya Mine, Kentaro Sugano, Mamoru Watanabe, Tooru Shimosegawa
Cholelithiasis is one of the commonest diseases in gastroenterology. Remarkable improvements in therapeutic modalities for cholelithiasis and its complications are evident. The Japanese Society of Gastroenterology has revised the evidence-based clinical practice guidelines for cholelithiasis. Forty-three clinical questions, for four categories-epidemiology and pathogenesis, diagnosis, treatments, and prognosis and complications-were selected, and a literature search was performed for the clinical questions with use of the MEDLINE, Cochrane, and Igaku Chuo Zasshi databases for the period between 1983 and June 2012...
December 10, 2016: Journal of Gastroenterology
https://www.readbyqxmd.com/read/27941278/long-term-follow-up-results-of-a-phase-i-ii-study-of-melphalan-prednisolone-and-bortezomib-in-japanese-transplant-ineligible-multiple-myeloma-patients-jpn-102
#17
Daisuke Ogiya, Hirohiko Shibayama, Eiji Nakatani, Kiyoshi Ando, Kenshi Suzuki, Yoshiaki Kuroda, Toshiki Uchida, Dai Maruyama, Morio Matsumoto, Kosei Matsue, Shinsuke Iida, Yasuhito Terui, Masaki Ri, Takaaki Chou, Nobuyuki Aotsuka, Sumie Tabata, Jun Konishi, Kazuteru Ohashi, Atsushi Shinagawa, Isamu Sugiura, Junya Kuroda, Toshihiro Miyamoto, Michinori Ogura, Kensei Tobinai, Yuzuru Kanakura, Tomomitsu Hotta
The phase I/II study of melphalan-prednisolone-bortezomib (MPB) therapy in Japanese patients with previously untreated multiple myeloma (MM) who are ineligible for hematopoietic stem cell transplantation (JPN-102 trial) (registered between July 2008 and March 2011) showed an overall response rate in the MPB arm equivalent to that of the VISTA trial. In this study, we followed up the clinical data of 92 of the 101 patients registered in the JPN-102 trial to clarify the long-term outcomes of MPB therapy. The median follow-up period was 50...
2016: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/27938918/findings-of-the-maintenance-of-wakefulness-test-and-its-relationship-with-response-to-modafinil-therapy-for-residual-excessive-daytime-sleepiness-in-obstructive-sleep-apnea-patients-adequately-treated-with-nasal-continuous-positive-airway-pressure
#18
Yuichi Inoue, Masuo Miki, Toshiyuki Tabata
OBJECTIVE: We aimed to examine the relationship between subjective and objective sleepiness in obstructive sleep apnea syndrome (OSAS) patients with residual sleepiness, and to determine whether baseline objective sleepiness severity predicts the response to modafinil therapy. METHODS: Data were obtained from a randomized, placebo-controlled modafinil (200 mg/day) study in Japanese OSAS patients with residual sleepiness receiving nasal continuous positive pressure (n-CPAP) treatment...
November 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27932926/a-dataset-of-fishes-in-and-around-inle-lake-an-ancient-lake-of-myanmar-with-dna-barcoding-photo-images-and-ct-3d-models
#19
Yuichi Kano, Prachya Musikasinthorn, Akihisa Iwata, Sein Tun, Lkc Yun, Seint Seint Win, Shoko Matsui, Ryoichi Tabata, Takeshi Yamasaki, Katsutoshi Watanabe
BACKGROUND: Inle (Inlay) Lake, an ancient lake of Southeast Asia, is located at the eastern part of Myanmar, surrounded by the Shan Mountains. Detailed information on fish fauna in and around the lake has long been unknown, although its outstanding endemism was reported a century ago. NEW INFORMATION: Based on the fish specimens collected from markets, rivers, swamps, ponds and ditches around Inle Lake as well as from the lake itself from 2014 to 2016, we recorded a total of 948 occurrence data (2120 individuals), belonging to 10 orders, 19 families, 39 genera and 49 species...
2016: Biodiversity Data Journal
https://www.readbyqxmd.com/read/27932506/synthetic-mri-in-the-detection-of-multiple-sclerosis-plaques
#20
A Hagiwara, M Hori, K Yokoyama, M Y Takemura, C Andica, T Tabata, K Kamagata, M Suzuki, K K Kumamaru, M Nakazawa, N Takano, H Kawasaki, N Hamasaki, A Kunimatsu, S Aoki
BACKGROUND AND PURPOSE: Synthetic MR imaging enables the creation of various contrast-weighted images including double inversion recovery and phase-sensitive inversion recovery from a single MR imaging quantification scan. Here, we assessed whether synthetic MR imaging is suitable for detecting MS plaques. MATERIALS AND METHODS: Quantitative and conventional MR imaging data on 12 patients with MS were retrospectively analyzed. Synthetic T2-weighted, FLAIR, double inversion recovery, and phase-sensitive inversion recovery images were produced after quantification of T1 and T2 values and proton density...
December 8, 2016: AJNR. American Journal of Neuroradiology
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