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https://www.readbyqxmd.com/read/28634935/generation-of-induced-pluripotent-stem-cells-in-defined-three-dimensional-hydrogels
#1
Massimiliano Caiazzo, Yoji Tabata, Matthias Lutolf
Since the groundbreaking discovery of induced pluripotent stem cells (iPSCs) many research groups have attempted to improve the efficiency of the classical cell reprogramming process. Surprisingly, the contribution of the three-dimensional (3D) microenvironment to iPSC generation has been largely overlooked. Here we describe a protocol for the generation of iPSCs in defined poly(ethylene glycol) (PEG)-based hydrogels that, besides allowing higher reprogramming efficiency, are also a powerful tool to study the influence of biophysical parameters on iPSC generation...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28633912/life-cycle-assessment-and-life-cycle-costs-for-pre-disaster-waste-management-systems
#2
Yohei Wakabayashi, Tsai Peii, Tomohiro Tabata, Takashi Saeki
This study develops a method of environmental and economic evaluation of an integrated disaster waste management system that considers the spatial scale of removal, transport, and treatment of disaster waste. A case study was conducted on combustibles, which is a type of disaster waste derived from dwellings, in Mie Prefecture, Japan. First, we calculated the quantity and the spatial distribution of disaster waste derived from dwellings and tsunami debris produced as a result of a large-scale earthquake. The quantity of disaster waste was estimated as 7,178,000t with functioning flood-preventing facilities and 11,956,000t without functioning flood prevention facilities...
June 17, 2017: Waste Management
https://www.readbyqxmd.com/read/28616567/cyp2c19-variants-and-epoxyeicosatrienoic-acids-in-patients-with-microvascular-angina
#3
Tomonori Akasaka, Daisuke Sueta, Yuichiro Arima, Noriaki Tabata, Seiji Takashio, Yasuhiro Izumiya, Eiichiro Yamamoto, Kenichi Tsujita, Sunao Kojima, Koichi Kaikita, Ayami Kajiwara, Kazunori Morita, Kentaro Oniki, Junji Saruwatari, Kazuko Nakagawa, Seiji Hokimoto
BACKGROUND: Categorization as a cytochrome P450 (CYP) 2C19 poor metabolizer (PM) is reported to be an independent risk factor for cardiovascular disease. Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid by CYP2C19 epoxygenases and anti-inflammatory properties, especially in microvascular tissues. We examined the impact of CYP2C19 polymorphisms and EETs on the patients with microvascular angina (MVA) caused by coronary microvascular dysfunction. METHODS AND RESULTS: We examined CYP2C19 genotypes in patients with MVA (n = 81)...
June 2017: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/28616549/changes-in-the-risk-factors-for-coronary-spasm
#4
Masanobu Ishii, Koichi Kaikita, Koji Sato, Kenshi Yamanaga, Takashi Miyazaki, Tomonori Akasaka, Noriaki Tabata, Yuichiro Arima, Daisuke Sueta, Kenji Sakamoto, Eiichiro Yamamoto, Kenichi Tsujita, Megumi Yamamuro, Sunao Kojima, Hirofumi Soejima, Seiji Hokimoto, Kunihiko Matsui, Hisao Ogawa
No abstract text is available yet for this article.
September 2016: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/28607101/positive-and-negative-control-pathways-by-blood-components-for-intermedilysin-production-in-streptococcus-intermedius
#5
Toshifumi Tomoyasu, Takahiro Yamasaki, Shinya Chiba, Shingo Kusaka, Atsushi Tabata, Robert A Whiley, Hideaki Nagamune
Streptococcus intermedius is an opportunistic bacterial pathogen secreting a human-specific cytolysin called intermedilysin (ILY) as a major pathogenic factor. This bacterium can degrade glycans into monosaccharides using two glycosidases, multisubstrate glycosidase A (MsgA) and neuraminidase (NanA). Here, we detected a strong hemolytic activity mediated by ILY when Sintermedius PC574 was cultured in fetal bovine serum (FBS) as compared to the standard culture medium. FBS-cultured cells also showed higher MsgA and NanA activity although overproduction of ILY in FBS was undetectable in mutants nanA-null and msgA-null...
June 12, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28595225/-mitral-valve-repair-in-a-patient-with-two-aneurysms-of-the-mitral-valve-due-to-infective-endocarditis-report-of-a-case
#6
Maiko Tsuji, Dai Une, Atsushi Kurata, Mimiko Tabata, Takayoshi Matsuyama, Hiroshi Seki, Akiyo Uda, Tomonobu Beika
Echocardiography revealed 2 aneurysms in the mitral valve with mitral regurgitation and aortic regurgitation,in a 42-years-old man. He had had infective endocarditis due to Streptococcus 9 months before. A prolapse in the right coronary cusp without vegetation and 2 aneurysms in the anterior mitral leaflet were found intraoperatively. Aortic valve was replaced, and then mitral aneurysms were resected and repaired using his own pericardium. There has been almost no regurgitation or recurrence of infection over 3 years...
June 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28594914/associations-between-dental-knowledge-source-of-dental-knowledge-and-oral-health-behavior-in-japanese-university-students-a-cross-sectional-study
#7
Ayano Taniguchi-Tabata, Daisuke Ekuni, Shinsuke Mizutani, Mayu Yamane-Takeuchi, Kota Kataoka, Tetsuji Azuma, Takaaki Tomofuji, Yoshiaki Iwasaki, Manabu Morita
The aim of this study was to investigate the associations between dental knowledge, the source of dental knowledge and oral health behavior in a group of students at a university in Japan. A total of 2,220 university students (1,276 males, 944 females) volunteered to undergo an oral examination and answer a questionnaire. The questionnaire assessed dental knowledge, the source of dental knowledge and oral health behavior (e.g., daily frequency of tooth brushing, use of dental floss and regular dental checkups)...
2017: PloS One
https://www.readbyqxmd.com/read/28594865/gender-linked-impact-of-epicardial-adipose-tissue-volume-in-patients-who-underwent-coronary-artery-bypass-graft-surgery-or-non-coronary-valve-surgery
#8
Gulinu Maimaituxun, Michio Shimabukuro, Hotimah Masdan Salim, Minoru Tabata, Daisuke Yuji, Yoshihisa Morimoto, Takeshi Akasaka, Tomomi Matsuura, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Takaki Sugimoto, Masashi Tanaka, Shuichiro Takanashi, Masataka Sata
BACKGROUND: Traditional and non-traditional risk factors for atherosclerotic cardiovascular disease (ASCVD) are different between men and women. Gender-linked impact of epicardial adipose tissue volume (EATV) in patients undergoing coronary artery bypass grafting (CABG) remains unknown. METHODS: Gender-linked impact of EATV, abdominal fat distribution and other traditional ASCVD risk factors were compared in 172 patients (men: 115; women: 57) who underwent CABG or non-coronary valvular surgery (non-CABG)...
2017: PloS One
https://www.readbyqxmd.com/read/28594111/bone-histomorphometry-in-an-osteoporotic-hemodialysis-patient-treated-with-denosumab
#9
Yajima Ibuki, Toyosi Hukuda, Sakuyosi Tabata, Akemi Ito
No abstract text is available yet for this article.
June 8, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28576616/discovery-of-highly-reactive-peptide-tag-by-elisa-type-screening-for-specific-cysteine-conjugation
#10
Nobutaka Kurashige, Hirokazu Fuchida, Shigekazu Tabata, Shohei Uchinomiya, Akio Ojida
We report the discovery of a highly reactive peptide tag for the specific cysteine conjugation of proteins. Screening of cysteine-containing peptides using ELISA-type screening yielded a 19-amino acid tag (DCPPPDDAADDAADDAADD), named DCP3 tag, which enabled the rapid and selective labeling of the tag-fused protein with a synthetic zinc complex on the surface of living cells.
May 24, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28574635/estradiol-inhibits-hepatic-stellate-cell-area-and-collagen-synthesis-in-the-chicken-liver
#11
Shotaro Nishimura, Akifumi Teshima, Fuminori Kawabata, Shoji Tabata
Hepatic stellate cells (HSCs) are the main collagen-producing cells in the liver. The HSC area and amount of collagen fibers are different between male and female chickens. This study was performed to confirm the effect of estradiol on collagen synthesis in the growing chicken liver. Blood estradiol levels in chicks were compared at 4 and 8 weeks of age, and the collagen fibril network in liver tissue was observed at 8 weeks by scanning electron microscopy. Intraperitoneal administrations of estradiol and tamoxifen to male and female chicks, respectively, were performed daily from 5 to 8 weeks of age...
June 2, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28538878/hidradenitis-suppurativa-epidemiological-study-of-cases-diagnosed-at-a-dermatological-reference-center-in-the-city-of-bauru-in-the-brazilian-southeast-state-of-s%C3%A3-o-paulo-between-2005-and-2015
#12
Tatiana Cristina Pedro Cordeiro de Andrade, Bruna Cortinóvis Vieira, Agnes Mayumi Nakano Oliveira, Tábata Yamasaki Martins, Tatiane Meira Santiago, Antônio Carlos Ceribelli Martelli
Background: Hidradenitis is a chronic inflammatory disease of the hair follicles. A treatment is necessary due to chronicity and psychological changes that patient present. Objective: To investigate epidemiological aspects and elaborate a risk group profile, promote early diagnosis and contribute to the knowledge about the disease. Methods: This cross-sectional descriptive study with retrospective analysis of medical records of 194 patients diagnosed with hidrosadenitis in a dermatological reference center in the city of Bauru (SP) between 2005 and 2015...
March 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28533121/recent-progress-in-hepatocyte-culture-models-and-their-application-to-the-assessment-of-drug-metabolism-transport-and-toxicity-in-drug-discovery-the-value-of-tissue-engineering-for-the-successful-development-of-a-microphysiological-system
#13
REVIEW
Kazuhiro Tetsuka, Masato Ohbuchi, Kenji Tabata
Tissue engineering technology has provided many useful culture models. This article reviews the merits of this technology in a hepatocyte culture system, and describes the applications of the sandwich-cultured hepatocyte model in drug discovery. In addition, we also review recent investigations of the utility of the three-dimensional bioprinted human liver tissue model and spheroid model. Finally, we present the future direction and developmental challenges of a hepatocyte culture model for the successful establishment of a microphysiological system, represented as an organ-on-a-chip and even as a human-on-a-chip...
May 19, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28529744/prognostic-effect-of-serum-c-reactive-protein-kinetics-on-advanced-renal-cell-carcinoma-treated-with-sunitinib
#14
Tetsuo Fujita, Ken-Ichi Tabata, Daisuke Ishii, Kazumasa Matsumoto, Kazunari Yoshida, Masatsugu Iwamura
C-reactive protein (CRP) is an independent prognostic factor for renal cell carcinoma (RCC). The aim of the present study was to investigate the prognostic effect of pretreatment serum CRP level and CRP kinetics on patients with advanced RCC treated with sunitinib. A total of 56 consecutive patients with advanced RCC treated with sunitinib between December, 2008 and December, 2012 were enrolled in the present study. The patients were retrospectively divided into 3 cohorts according to pretreatment serum CRP level and CRP kinetics: i) Normal CRP cohort (pretreatment CRP ≤0...
May 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28514652/thymidine-catabolism-as-a-metabolic-strategy-for-cancer-survival
#15
Sho Tabata, Masatatsu Yamamoto, Hisatsugu Goto, Akiyoshi Hirayama, Maki Ohishi, Takuya Kuramoto, Atsushi Mitsuhashi, Ryuji Ikeda, Misako Haraguchi, Kohichi Kawahara, Yoshinari Shinsato, Kentaro Minami, Atsuro Saijo, Masaki Hanibuchi, Yasuhiko Nishioka, Saburo Sone, Hiroyasu Esumi, Masaru Tomita, Tomoyoshi Soga, Tatsuhiko Furukawa, Shin-Ichi Akiyama
Thymidine phosphorylase (TP), a rate-limiting enzyme in thymidine catabolism, plays a pivotal role in tumor progression; however, the mechanisms underlying this role are not fully understood. Here, we found that TP-mediated thymidine catabolism could supply the carbon source in the glycolytic pathway and thus contribute to cell survival under conditions of nutrient deprivation. In TP-expressing cells, thymidine was converted to metabolites, including glucose 6-phosphate, lactate, 5-phospho-α-D-ribose 1-diphosphate, and serine, via the glycolytic pathway both in vitro and in vivo...
May 16, 2017: Cell Reports
https://www.readbyqxmd.com/read/28501481/effect-of-lymphadenectomy-during-radical-nephroureterectomy-in-locally-advanced-upper-tract-urothelial-carcinoma
#16
Masaomi Ikeda, Kazumasa Matsumoto, Kazushige Sakaguchi, Daisuke Ishii, Ken-Ichi Tabata, Kazuhiro Kurosawa, Shinji Urakami, Toshikazu Okaneya, Masatsugu Iwamura
BACKGROUND: The role of lymph node dissection (LND) for upper tract urothelial carcinoma (UTUC) patients remains controversial. The aim of this study was to evaluate the effect of LND on clinical outcomes during radical nephroureterectomy (RNU) and to determine prognostic factors of survival. PATIENTS AND METHODS: From 1985 to 2013, 404 patients with UTUC underwent RNU; 5 patients who received neoadjuvant chemotherapy were excluded. Among them, 182 (46%) were pathologically negative for lymph node metastasis (pN0), 177 (44%) were non-LND (pNx), and 40 (10%) were positive for lymph nodes metastasis (pN1/2)...
April 10, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28486343/fractional-exhaled-nitric-oxide-feno-and-spirometry-as-indicators-of-inhalation-exposure-to-chemical-agents-in-pathology-workers
#17
Ritsuko Arakawa Suzuki, Toshiya Irokawa, Hiromasa Ogawa, Shinya Ohkouchi, Masao Tabata, Susumu Togashi, Takeshi Nakamura, Noriko Ohisa, Etsuhiro Nikkuni, Emiri Miura, Kaoru Yoshida, Hiroshi Inomata, Hajime Kurosawa
OBJECTIVE: The objective of this study was to examine whether fractional exhaled nitric oxide (FeNO) and spirometry can be used as indices to evaluate adverse health effects of low-concentrated chemical inhalation exposure, mainly to formaldehyde. METHODS: Thirty-three subjects (pathology technicians) and 30 controls (workers without handling any chemicals in the same hospitals) participated in this study. All participants underwent FeNO measurement and spirometry before and after 5 days of work...
May 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28483695/augmented-liver-targeting-of-exosomes-by-surface-modification-with-cationized-pullulan
#18
Ryo Tamura, Shinji Uemoto, Yasuhiko Tabata
Exosomes are membrane nanoparticles containing biological substances that are employed as therapeutics in experimental inflammatory models. Surface modification of exosomes for better tissue targetability and enhancement of their therapeutic ability was recently attempted mainly using gene transfection techniques. Here, we show for the first time that the surface modification of exosomes with cationized pullulan, which has the ability to target hepatocyte asialoglycoprotein receptors, can target injured liver and enhance the therapeutic effect of exosomes...
May 5, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28480529/acne-conglobata-in-a-long-term-survivor-with-trisomy-13-accompanied-by-selective-igm-deficiency
#19
Chiyoko N Inoue, Yoshiko Tanaka, Nobuko Tabata
Trisomy 13 (T13) is a congenital chromosomal disorder that is usually fatal within 2 years of birth, and only a few patients have been reported to reach adolescence. Here, we report a male long-term survivor of T13, currently 15 years of age, with a several-year history of extensive acne conglobata (AC) with abscesses on the face and neck. Methicillin-resistant Staphylococcus aureus was consistently isolated from the pustular lesions. Serum IgM levels were extremely low at 10 mg/dl. There were no abnormalities in neutrophil and total B cell number, or in serum IgA and IgG levels...
May 7, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28475329/tolvaptan-type-vasopressin-receptor-ligands-important-role-of-axial-chirality-in-the-active-form
#20
Hidetsugu Tabata, Tetsuya Yoneda, Tetsuta Oshitari, Hideyo Takahashi, Hideaki Natsugari
The anti and syn isomers of tolvaptan-type compounds, N-benzoyl-5-hydroxy-1-benzazepines (5a-c), were prepared in a stereocontrolled manner by biasing the conformation with a methyl group at C9 and C6, respectively, and the enantiomeric forms were separated. Examination of the affinity at the human vasopressin receptors revealed that the axial chirality (aS) plays a more important role than the central chirality at C5 in receptor recognition, and the most preferable form was shown to be (E,aS,5S).
May 25, 2017: Journal of Medicinal Chemistry
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