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https://www.readbyqxmd.com/read/29243995/the-relationship-of-erectile-dysfunction-and-subclinical-cardiovascular-disease-a-systematic-review-and-meta-analysis
#1
Chukwuemeka U Osondu, Bryan Vo, Ebenezer T Oni, Michael J Blaha, Emir Veledar, Theodore Feldman, Arthur S Agatston, Khurram Nasir, Ehimen C Aneni
Erectile dysfunction (ED) is associated with cardiovascular disease (CVD) and CVD mortality. However, the relationship between ED and subclinical CVD is less clear. We synthesized the available data on the association of ED and measures of subclinical CVD. We searched multiple databases for published literature on studies examining the association of ED and measures of subclinical CVD across four domains: endothelial dysfunction measured by flow-mediated dilation (FMD), carotid intima-media thickness (cIMT), coronary artery calcification (CAC), and other measures of vascular function such as the ankle-brachial index, toe-brachial index, and pulse wave velocity...
December 1, 2017: Vascular Medicine
https://www.readbyqxmd.com/read/29243272/chronic-kidney-disease-and-coronary-artery-calcification-in-the-brazilian-longitudinal-study-of-adult-health-elsa-brasil
#2
Cheng Suh-Chiou, Rosa M Moysés, Marcio S Bittencourt, Isabela M Bensenor, Paulo A Lotufo
BACKGROUND: Chronic kidney disease is a worldwide public health concern due to the increased prevalence the high fatalities related to heart disease in this population. Among novel cardiovascular risk markers, the coronary artery calcification score (CAC) emerged as an independent predictor of cardiovascular events. HYPOTHESIS: We aimed to test if glomerular filtration rate or albuminuria are independently associated with coronary calcification. METHODS: The Brazilian Longitudinal Study of Adult Health is a cohort of men and women aged 35 to 74 years old addressing cardiovascular diseases...
December 15, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/29241485/normal-ldl-cholesterol-levels-are-associated-with-subclinical-atherosclerosis-in-the-absence-of-risk%C3%A2-factors
#3
Leticia Fernández-Friera, Valentín Fuster, Beatriz López-Melgar, Belén Oliva, José M García-Ruiz, José Mendiguren, Héctor Bueno, Stuart Pocock, Borja Ibáñez, Antonio Fernández-Ortiz, Javier Sanz
BACKGROUND: Absence of cardiovascular risk factors (CVRFs) is traditionally considered low risk for atherosclerosis; however, individuals without CVRFs, as currently defined, still have events. OBJECTIVES: This study sought to identify predictors of subclinical atherosclerosis in CVRF-free individuals. METHODS: Participants from the PESA (Progression of Early Subclinical Atherosclerosis) study (n = 4,184) without conventional CVRFs were evaluated (n = 1,779; 45...
December 19, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29240557/impact-of-motion-compensation-and-partial-volume-correction-for-18f-naf-pet-ct-imaging-of-coronary-plaque
#4
J Cal-González, C Tsoumpas, M L Lassen, S Rasul, L Koller, M Hacker, K Schäfers, T Beyer
Recent studies have suggested that 18F-NaF-PET enables visualization and quantification of plaque micro-calcification in the coronary tree. However, PET imaging of plaque calcification in the coronary arteries is challenging because of the respiratory and cardiac motion as well as partial volume effects. The objective of this work is to implement an image reconstruction framework, which incorporates compensation for respiratory as well as cardiac motion (MoCo) and partial volume correction (PVC), for cardiac 18F-NaF PET imaging in PET/CT...
December 14, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29236951/epicardial-adipose-tissue-volume-assessed-by-computed-tomography-and-coronary-artery-disease-a-systematic-review-and-meta-analysis
#5
Jennifer Mancio, Diana Azevedo, Francisca Saraiva, Ana Isabel Azevedo, Gustavo Pires-Morais, Adelino Leite-Moreira, Ines Falcao-Pires, Nuno Lunet, Nuno Bettencourt
To conduct a systematic review and meta-analysis on the crude and adjusted associations between epicardial adipose tissue (EAT) volume determined by computed tomography (CT) and coronary artery disease (CAD). MEDLINE, Scopus, and Web of Science databases were screened for all observational studies assessing the association between EAT volume and CAD. We calculated pooled odds ratio (OR) or hazard ratio (HR) and 95% confidence intervals (CI) for the association per 10 cm3 variation of EAT by five different definitions of CAD: obstructive or significant coronary stenosis (luminal narrowing ≥50% and ≥70%, respectively), presence of coronary artery calcification (CAC), myocardial ischaemia, and major adverse cardiovascular events (MACE) using DerSimonian and Laird random-effects models...
December 9, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29227975/high-phosphate-induced-calcification-of-vascular-smooth-muscle-cells-is-associated-with-the-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway
#6
Daohai Zhang, Xianjin Bi, Yong Liu, Yinghui Huang, Jiachuan Xiong, Xinli Xu, Tangli Xiao, Yanlin Yu, Wei Jiang, Yunjian Huang, Jingbo Zhang, Bo Zhang, Jinghong Zhao
BACKGROUND/AIMS: Hyperphosphatemia is one of the most notable features of chronic kidney disease (CKD). Numerous epidemiological and clinical studies have found that high serum phosphate concentrations are associated with calcification in the coronary arteries. However, the mechanisms underlying the vascular calcification induced by high phosphate have not been understood fully. METHODS: Vascular smooth muscle cells (VSMCs) were cultured in high-phosphate media to induce vascular calcification, which was detected by Alizarin red S staining...
December 8, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29227122/-hamartoma-of-mature-cardiac-myocytes-autopsy-case-report
#7
Šárka Hadravská, Magdaléna Dubová, Markéta Miesbauerová, Petr Mukenšnabl, Ondřej Daum, Alois Mádle, Karel Smetana
Hamartoma of mature cardiac myocytes (HMCM) is a rare benign pseudoneoplastic myocardial lesion. We describe a case of 39-year-old Bulgarian woman living in the Czech Republic, who died because of rupture of anterior communicating artery aneurysm, and severe bronchopneumonia. An incidental finding at the autopsy was a whitish unencapsulated and not sharply demarcated tumor of the left ventricle and adjacent area of interventricular septum, which protruded above the plane of section. Microscopically the tumor consisted of various different forms of disorganized hypertrophic mature cardiac myocytes without vacuolization of cytoplasm, focally in a "herringbone" pattern...
2017: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/29225032/calcification-of-thoracic-and-abdominal-aneurysms-is-associated-with-mortality-and-morbidity
#8
Mohammed M Chowdhury, Lukasz P Zieliński, James J Sun, Simon Lambracos, Jonathan R Boyle, Seamus C Harrison, James H F Rudd, Patrick A Coughlin
INTRODUCTION: Cardiovascular events are common in people with aortic aneurysms. Arterial calcification is a recognised predictor of cardiovascular outcomes in coronary artery disease. Whether calcification within abdominal and thoracic aneurysm walls is correlated with poor cardiovascular outcomes is not known. PATIENTS AND METHODS: Calcium scores were derived from computed tomography (CT) scans of consecutive patients with either infrarenal (AAA) or descending thoracic aneurysms (TAA) using the modified Agatston score...
December 7, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29222954/evaluation-of-motion-artifact-metrics-for-coronary-ct-angiography
#9
Hongfeng Ma, Eric Gros, Aniko Szabo, Scott G Baginski, Zachary R Laste, Naveen M Kulkarni, Darin Okerlund, Taly G Schmidt
PURPOSE: This study quantified the performance of coronary artery motion artifact metrics relative to human observer ratings. Motion artifact metrics have been used as part of motion correction and best-phase selection algorithms for Coronary Computed Tomography Angiography (CCTA). However, the lack of ground truth makes it difficult to validate how well the metrics quantify the level of motion artifact. This study investigated five motion artifact metrics, including two novel metrics, using a dynamic phantom, clinical CCTA images, and an observer study that provided ground truth motion artifact scores from a series of pairwise comparisons...
December 9, 2017: Medical Physics
https://www.readbyqxmd.com/read/29220755/coronary-artery-calcification-predicts-cardiovascular-complications-after-sepsis
#10
Vedant A Gupta, Matthew Sousa, Nathan Kraitman, Rahul Annabathula, Olga Vsevolozhskaya, Steve W Leung, Vincent L Sorrell
PURPOSE: Sepsis is a highly prevalent and fatal condition, with reported cardiovascular event rates as high as 25-30% at 1year. Risk stratification in septic patients has been extremely limited. MATERIAL AND METHODS: 267 septic patients with detectable troponin levels, APACHE II scores, and CT scans of the chest or abdomen were assessed. Patients with a recent cardiac intervention were excluded. Coronary artery calcification (CAC) was identified as present or absent on body CT scans...
December 2, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29220533/androgens-irregular-menses-and-risk-of-diabetes-and-coronary-artery-calcification-in-the-diabetes-prevention-program
#11
Catherine Kim, Vanita R Aroda, Ronald B Goldberg, Naji Younes, Sharon L Edelstein, MaryLou Carrion-Petersen, David A Ehrmann
Context: It is unclear whether relative elevations in androgens or irregular menses (IM) are associated with greater cardiometabolic risk among women who are already overweight and glucose intolerant. Research Design and Methods: We conducted a secondary analysis of Diabetes Prevention Program (DPP) and the DPP Outcomes Study (DPPOS). Participants included women with sex hormone measurements who did not use exogenous estrogen (n=1422). We examined whether free androgen index (FAI) or IM were associated with diabetes risk during the DPP/DPPOS or with coronary artery calcification (CAC) at DPPOS year 10...
December 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29212987/association-of-coronary-artery-calcification-with-estimated-coronary-heart-disease-risk-from-prediction-models-in-a-community-based-sample-of-japanese-men-the-shiga-epidemiological-study-of-subclinical-atherosclerosis-sessa
#12
Akira Fujiyoshi, Hisatomi Arima, Sachiko Tanaka-Mizuno, Takahashi Hisamatsu, Sayaka Kadowaki, Aya Kadota, Maryam Zaid, Akira Sekikawa, Takashi Yamamoto, Minoru Horie, Katsuyuki Miura, Hirotsugu Ueshima
AIM: The clinical significance of coronary artery calcification (CAC) is not fully determined in general East Asian populations where background coronary heart disease (CHD) is less common than in USA/Western countries. We cross-sectionally assessed the association between CAC and estimated CHD risk as well as each major risk factor in general Japanese men. METHODS: Participants were 996 randomly selected Japanese men aged 40-79 y, free of stroke, myocardial infarction, or revascularization...
December 5, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29210840/conoscere-e-curare-il-cuore-1986-2016-how-the-heart-has-changed
#13
Alessandro Boccanelli
: The demographic transition, with longer life expectancy, is mainly due to prevention and care of atherosclerotic vascular and heart disease. The cardiovascular patient is now much older and often presents with coexisting geriatric syndromes that affect healthcare goals, outcomes, and the process of care. Numerous mechanisms at cellular level are responsible for cardiovascular aging such as replicative senescence, apoptosis, proteins misfolding, and inflammation. Aging-related modifications are increase in left-ventricular mass, increased left atrial size, myocardial collagen deposition, and calcium deposition in valvular structures and the coronary arteries...
November 27, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29210019/pathology-of-stent-implantation-in-internal-mammary-artery
#14
Hiroyoshi Mori, Ryan Braumann, Sho Torii, Hiroyuki Jinnouchi, Emanuel Harari, Robert Kutys, Maria Romero, Renu Virmani, Aloke Finn
The internal mammary artery (IMA) is the most durable conduit for bypassing the left anterior descending (LAD) coronary artery in patients undergoing coronary artery bypass graft surgery (CABG). However, little is known about how the IMA reacts histologically to stent implantation. From CVPath stent registry (1048 lesions, 614 cases), we obtained 4 stent lesions (2 bare metal stents, 2 drug-eluting stents) involving IMA grafts. The mean age of our patients was 63 years and the duration of stent implantation in the IMA ranged from 5 days to 5 years...
December 5, 2017: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/29198984/relation-of-an-echocardiographic-based-cardiac-calcium-score-to-mitral-stenosis-severity-and-coronary-artery-disease-in-patients-with-severe-aortic-stenosis
#15
Siyuan P Sheng, Lucius A Howell, Melissa C Caughey, Michael Yeung, John P Vavalle
Patients with calcific aortic stenosis (AS) often have diffuse cardiac calcification involving the mitral valve apparatus and coronary arteries. We examined the association between global cardiac calcification quantified by a previously validated echocardiographic calcium score (eCS) with the severity of mitral stenosis (MS) and coronary artery disease (CAD) in patients with a clinical diagnosis of severe calcific AS. In this sample of 147 patients (mean age 81 ± 9 years, 50% male), 81 patients (55%) were determined by echocardiography to have some degree of MS...
October 26, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29198686/orthotopic-kidney-transplantation-in-an-elderly-patient-with-various-severe-comorbid-conditions-a-case-report
#16
H Sasaki, R Nakazawa, T Iwata, W Usuba, H Yoshie, E Fujimoto, H Metoki, Y Katsuoka, K Aida, H Kudo, K Koitabashi, M Yazawa, Y Shibagaki, Y Marui, T Chikaraishi
In recent years, the frequency of high-risk kidney transplantations has increased. We report a case in which a 72-year-old man with various severe comorbidities (prostate cancer, diabetes mellitus, complete atrioventricular block, coronary artery stenosis, severe stenosis of the popliteal arteries, and severe calcification of the iliac arteries) who received an orthotopic kidney transplantation. To prevent the occurrence of acute limb ischemia due to the steal phenomenon (caused by the kidney graft), we decided that a heterotopic kidney transplantation involving the iliac arteries was not an appropriate option...
December 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29197025/german-cardiac-ct-registry-indications-procedural-data-and-clinical-consequences-in-7061-patients-undergoing-cardiac-computed-tomography
#17
Mohamed Marwan, Stephan Achenbach, Grigorios Korosoglou, Axel Schmermund, Steffen Schneider, Oliver Bruder, Jörg Hausleiter, Stephen Schroeder, Sebastian Barth, Sebastian Kerber, Alexander Leber, Werner Moshage, Jochen Senges
Cardiac computed tomography permits quantification of coronary calcification as well as detection of coronary artery stenoses after contrast enhancement. Moreover, cardiac CT offers high-resolution morphologic and functional imaging of cardiac structures which is valuable for various structural heart disease interventions and electrophysiology procedures. So far, only limited data exist regarding the spectrum of indications, image acquisition parameters as well as results and clinical consequences of cardiac CT examinations using state-of-the-art CT systems in experienced centers...
December 1, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29194090/the-association-between-uric-acid-levels-and-different-clinical-manifestations-of-coronary-artery-disease
#18
Trine R Larsen, Oke Gerke, Axel C P Diederichsen, Jess Lambrechtsen, Flemming H Steffensen, Niels P Sand, Lotte Saaby, Steen Antonsen, Hans Mickley
AIMS: Uric acid (UA) has been associated with the presence and severity of coronary artery disease. To further assess the role of UA role in coronary artery disease, we investigated UA levels in both healthy asymptomatic middle-aged individuals and in different subgroups of hospitalized patients with suspected or definite myocardial infarction (MI). PATIENTS AND METHODS: The severity of coronary artery calcification (CAC) was examined in asymptomatic individuals (n=1039) using a noncontrast computed tomography scan...
November 29, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29189397/patterns-of-coronary-calcification-and-their-impact-on-the-diagnostic-accuracy-of-computed-tomography-coronary-angiography
#19
Dariusz Noll, Mariusz Kruk, Marcin Demkow, Jerzy Pręgowski, Edyta Kaczmarska, Karolina Kryczka, Radosław Pracoń, Zofia Dzielińska, Justyna Śleszycka, Adam Witkowski, Witold Rużyłło, Cezary Kępka
OBJECTIVE: Despite coronary calcifications being a major factor affecting the diagnostic accuracy of coronary computed tomography angiography (CTA), there is a lack of established criteria for categorizing calcifications. We aimed to evaluate patterns of coronary calcification based on quantitative radiodensity and size parameters to provide coronary calcium categories and assess their impact on the accuracy of coronary CTA. METHODS AND RESULTS: We analyzed length, maximum thickness, volume, mean density, and maximum density of coronary calcium and divided each of these parameters into tertiles...
November 16, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/29189095/pregnancy-history-coronary-artery-calcification-and-bone-mineral-density-in-menopausal-women
#20
J P Beckman, J J Camp, B D Lahr, K R Bailey, A E Kearns, V D Garovic, M Jayachandran, V M Miller, D R Holmes
OBJECTIVE: This study examined relationships, by pregnancy histories, between bone mineral density (BMD) and coronary artery calcification (CAC) in postmenopausal women. METHODS: Forty women identified from their medical record as having pre-eclampsia (PE) were age/parity-matched with 40 women having a normotensive pregnancy (NP). Vertebral (T4-9) BMD and CAC were assessed by quantitative computed tomography in 73 (37 with PE and 36 with NP) of the 80 women. Analyses included linear regression using generalized estimating equations...
November 30, 2017: Climacteric: the Journal of the International Menopause Society
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