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coronary artery calcification

George A Mensah
The MESA (Multi-Ethnic Study of Atherosclerosis) has been highly successful in investigating the prevalence, characteristics, and progression of subclinical cardiovascular disease (CVD) in a multiethnic American cohort of adult men and women free of CVD at baseline. MESA has also championed the use of novel biomarkers and emerging imaging techniques for the assessment of subclinical CVD and has created an extensive set of data that continues to fuel dozens of ongoing analyses. Insights from MESA include the first demonstration of ethnic differences in coronary artery calcification and its association with subclinical disease progression and incident CVD...
September 2016: Global Heart
Alain G Bertoni, Holly Kramer, Karol Watson, Wendy S Post
Diabetes mellitus is a major cardiovascular risk factor and its prevalence has been increasing globally. This review examines the contributions of the MESA (Multi-Ethnic Study of Atherosclerosis), a diverse American cohort (6,814 adults ages 45 to 84, recruited from 2000 to 2002, 50% female, 62% nonwhite) toward understanding the relationship between diabetes and clinical and subclinical cardiovascular disease. People with diabetes have a high burden of subclinical vascular disease as measured by coronary artery calcification (CAC), carotid artery intima-media thickness, valvular calcification, and alterations in left ventricular structure...
September 2016: Global Heart
Kazuhiro Osawa, Rine Nakanishi, Matthew Budoff
Coronary artery calcification (CAC) is an established marker of subclinical atherosclerosis and an independent predictor of future coronary heart disease in the asymptomatic primary prevention population, particularly in the intermediate risk cohort. CAC also helps in reclassifying those patients and their risk of cardiovascular events into higher or lower risk categories. MESA (Multi-Ethnic Study of Atherosclerosis) is a National Heart, Lung, and Blood Institute-sponsored population-based medical research study involving 6,814 men and women from 6 U...
September 2016: Global Heart
Venkatesh L Murthy, Siddique A Abbasi, Juned Siddique, Laura A Colangelo, Jared Reis, Bharath A Venkatesh, J Jeffrey Carr, James G Terry, Sarah M Camhi, Michael Jerosch-Herold, Sarah de Ferranti, Saumya Das, Jane Freedman, Mercedes R Carnethon, Cora E Lewis, Joao A C Lima, Ravi V Shah
BACKGROUND: Despite evidence suggesting that early metabolic dysfunction impacts cardiovascular disease risk, current guidelines focus on risk assessments later in life, missing early transitions in metabolic risk that may represent opportunities for averting the development of cardiovascular disease. METHODS AND RESULTS: In 4420 young adults in the Coronary Artery Risk Development in Young Adults (CARDIA) study, we defined a "metabolic" risk score based on components of the Third Report of the Adult Treatment Panel's definition of metabolic syndrome...
October 13, 2016: Journal of the American Heart Association
Mitsuyasu Terashima, Hideaki Kaneda, Tetsuo Matsubara, Takahiko Suzuki
No abstract text is available yet for this article.
October 13, 2016: Acute Cardiac Care
Allison J Carroll, Mercedes R Carnethon, Kiang Liu, David R Jacobs, Laura A Colangelo, Jesse C Stewart, J Jeffrey Carr, Rachel Widome, Reto Auer, Brian Hitsman
Objective: Evaluate whether smoking exposure and depressive symptoms accumulated over 25 years are synergistically associated with subclinical heart disease, measured by coronary artery calcification (CAC). Method: Participants (baseline: 54.5% women; 51.5% Black; age range = 18-30 years) were followed prospectively from 1985 to 2010 in the Coronary Artery Risk Development in Young Adults (CARDIA) study. Smoking status was queried yearly from Year 0 to Year 25 to compute packyears of smoking exposure. Depressive symptoms were measured on the Center for Epidemiologic Studies Depression (CES-D) scale every 5 years to compute cumulative scores from Year 5 to Year 25...
October 13, 2016: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
Lijie Zhu, Jingjing Liu, Chuanyu Gao, Wenli Zhao, Jing Que, Xianpei Wang, Datun Qi, Jun Liu, Wentao Xiao, Juanjuan Yan, Wentao Li, You Zhang, Honghui Yang
OBJECTIVE: Diabetes substantially increases the risk of cardiovascular disease (CAD) and is associated with an increased risk of CAD mortality. The purpose of this study was to investigate the differences in coronary artery plaque, coronary artery calcification (CAC) measured in outpatients with and without type 2 diabetes, and the occurrence rate of a major adverse cardiac event (MACE) throughout follow-up with the same patients. METHODS: Five hundred eighty-eight outpatients with suspected CAD comprising 208 diabetic and 380 non-diabetic patients were enrolled in this study...
2016: SpringerPlus
John J B Anderson, Bridget Kruszka, Joseph A C Delaney, Ka He, Gregory L Burke, Alvaro Alonso, Diane E Bild, Matthew Budoff, Erin D Michos
BACKGROUND: Recent randomized data suggest that calcium supplements may be associated with increased risk of cardiovascular disease (CVD) events. Using a longitudinal cohort study, we assessed the association between calcium intake, from both foods and supplements, and atherosclerosis, as measured by coronary artery calcification (CAC). METHODS AND RESULTS: We studied 5448 adults free of clinically diagnosed CVD (52% female; aged 45-84 years) from the Multi-Ethnic Study of Atherosclerosis...
October 11, 2016: Journal of the American Heart Association
Henry D De'Ath, Kathryn Oakland, Karim Brohi
BACKGROUND: Arterial calcification on Computerised Tomography (CT) is a marker of cardiovascular disease. It is predictive of future adverse cardiac events and mortality in many disease states. The incidence of arterial disease and its impact on outcomes of the injured is not known. The objectives of this study were to describe the incidence of arterial calcification in trauma patients, and establish its impact on mortality. METHODS: A retrospective cohort study of all injured patients aged over 45 years presenting to a major trauma centre over a 34-month period...
October 10, 2016: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Anil Avci, Serdar Fidan, Mehmet Mustafa Tabakçı, Cuneyt Toprak, Elnur Alizade, Emrah Acar, Emrah Bayam, Muhammet Tellice, Abdurrahman Naser, Ramazan Kargın
BACKGROUND AND OBJECTIVES: The aim of this study was to evaluate the association between the extent of coronary artery disease assessed by the Gensini score and/or the SYNTAX score and the significant carotid stenosis in patients undergoing coronary artery bypass grafting (CABG). SUBJECTS AND METHODS: A total of 225 patients who had carotid doppler ultrasonography prior to CABG were included retrospectively. Significant coronary artery disease was assumed as a lumen diameter stenosis of ≥50% in any of the major epicardial coronary arteries...
September 2016: Korean Circulation Journal
Tetsuma Kawaji, Hiroki Shiomi, Hiroshi Morishita, Takeshi Morimoto, Charles A Taylor, Shotaro Kanao, Koji Koizumi, Satoshi Kozawa, Kazuhisa Morihiro, Hirotoshi Watanabe, Junichi Tazaki, Masao Imai, Naritatsu Saito, Satoshi Shizuta, Koh Ono, Kaori Togashi, Takeshi Kimura
Non-invasive fractional flow reserve measured by coronary computed tomography angiography (FFRCT) has demonstrated a high diagnostic accuracy for detecting coronary artery disease (CAD) in selected patients in prior clinical trials. However, feasibility of FFRCT in unselected population have not been fully evaluated. Among 60 consecutive patients who had suspected significant CAD by coronary computed tomography angiography (CCTA) and were planned to undergo invasive coronary angiography, 48 patients were enrolled in this study comparing FFRCT with invasive fractional flow reserve (FFR) without any exclusion criteria for the quality of CCTA image...
October 7, 2016: International Journal of Cardiovascular Imaging
Young-Mi Eun, Sung-Goo Kang, Sang-Wook Song
BACKGROUND: Prediabetes is associated with an increased risk of cardiovascular disease (CVD). While the association of impaired glucose tolerance with CVD has been shown in many studies, the relationship between impaired fasting glucose (IFG) and CVD remains unclear. OBJECTIVES: The purpose of this study was to compare the coronary artery calcium (CAC) scores of participants with normal fasting glucose versus those with IFG, according to fasting plasma glucose (FPG) levels, and to assess whether differences in CAC scores were independent of important confounders...
September 2016: Annals of Saudi Medicine
Eunjin Bae, Eun Yong Seong, Byoung-Geun Han, Dong Ki Kim, Chun Soo Lim, Shin-Wook Kang, Cheol Whee Park, Chan-Duck Kim, Byung Chul Shin, Sung Gyun Kim, Wookyung Chung, Jae Yoon Park, Joo Yeon Lee, Yon Su Kim
Introduction Patients with chronic kidney disease have an extremely high risk of developing cardiovascular disease (CVD). In patients with end-stage renal disease (ESRD), coronary artery calcification (CAC) is associated with increased mortality from CVD. Methods The present study aimed to investigate the risk factors for CAC in Korean patients with incident dialysis. Data on 423 patients with ESRD who started dialysis therapy between December 2012 and March 2014 were obtained from 10 university-affiliated hospitals...
October 5, 2016: Hemodialysis International
Aris Karatasakis, Barbara A Danek, Dimitri Karmpaliotis, Khaldoon Alaswad, Farouc A Jaffer, Robert W Yeh, Mitul P Patel, John N Bahadorani, R Michael Wyman, William L Lombardi, J Aaron Grantham, David E Kandzari, Nicholas J Lembo, Anthony H Doing, Jeffrey W Moses, Ajay J Kirtane, Santiago Garcia, Manish A Parikh, Ziad A Ali, Judit Karacsonyi, Sanjog Kalra, Bavana V Rangan, Pratik Kalsaria, Craig A Thompson, Subhash Banerjee, Emmanouil S Brilakis
OBJECTIVES: We sought to determine the impact of proximal cap ambiguity on procedural techniques and outcomes for coronary chronic total occlusion (CTO) percutaneous coronary intervention (PCI). METHODS: We examined the clinical and angiographic characteristics and outcomes of 1021 CTO-PCIs performed between 2012 and 2015 at 11 United States centers. RESULTS: Proximal cap ambiguity was present in 31% of target lesions and was associated with increased clinical and angiographic complexity (prior coronary artery bypass graft surgery: 43% vs 33%; P=...
October 2016: Journal of Invasive Cardiology
Hwa Seon Shin, Mi Jung Park, Kyung Nyeo Jeon, Jae Min Cho, Kyung Soo Bae, Dae Seob Choi, Jae Boem Na, Ho Cheol Choi, Hye Young Choi, Ji Eun Kim, Soo Bueum Cho, Sung Eun Park
BACKGROUND: Until now, there has been no study on the relationship between the calcification of the lower extremity arteries and significant coronary arterial disease (CAD). OBJECTIVES: To evaluate whether lower extremity calcium scores (LECS) are associated with CAD and whether this can predict multivessel-CAD in patients with peripheral arterial disease (PAD). PATIENTS AND METHODS: We retrospectively enrolled 103 PAD patients without cardiac symptoms or known CAD...
April 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
Olli Hartiala, Sami Kajander, Juhani Knuuti, Heikki Ukkonen, Antti Saraste, Irina Rinta-Kiikka, Sakari Kainulainen, Mika Kähönen, Nina Hutri-Kähönen, Tomi Laitinen, Terho Lehtimäki, Jorma S A Viikari, Jaakko Hartiala, Markus Juonala, Olli T Raitakari, Costan G Magnussen
BACKGROUND: Risk factors measured in early life have been shown to predict coronary artery calcium (CAC) in adulthood. However, limited data exist on when risk factor profiles of those who develop CAC diverge from those who do not. We investigated the associations of coronary heart disease risk factor trajectories beginning in adolescence and CAC measured at middle-age. METHODS: CAC was measured among 589 participants aged 39-45years in whom cardiovascular risk factors (serum lipids, blood pressure, body mass index, physical activity, smoking habits, and fruit, vegetable, fish, and butter intake) had been collected in 1980, 1983, 1986, 2001, and 2007 as part of the Cardiovascular Risk in Young Finns Study...
September 28, 2016: International Journal of Cardiology
Veeravich Jaruvongvanich, Kamonkiat Wirunsawanya, Anawin Sanguankeo, Sikarin Upala
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is associated increased cardiovascular events and mortality. Coronary artery calcium scanning (CAC) is the robust predictor of coronary events in the asymptomatic individuals. Several recent studies have investigated the association between NAFLD and this surrogate marker. Thus, we conducted a systematic review and meta-analysis to better characterize the association between NAFLD and CAC. METHODS: MEDLINE and EMBASE were searched through May 2016...
September 17, 2016: Digestive and Liver Disease
Iván Ferraz-Amaro, Robert Winchester, Peter K Gregersen, Richard J Reynolds, Mary Chester Wasko, Anette Oeser, Cecilia P Chung, C Michael Stein, Jon T Giles, Joan M Bathon
OBJECTIVE: Coronary artery disease (CAD) in the general population is characterized by an increased frequency of particular susceptibility single nucleotide polymorphisms (SNPs). Since CAD is increased in rheumatoid arthritis (RA), we sought to determine whether the frequency of these SNPs are increased in RA patients with CAD, hypothesizing that RA could enhance CAD risk by acting through established genetic pathways predisposing to CAD. METHODS: CAD was assessed by coronary artery calcification (CAC) using computed-tomography in 561 patients with RA...
October 1, 2016: Arthritis & Rheumatology
Laura Geraldino-Pardilla, Jon T Giles, Jeremy Sokolove, Afshin Zartoshti, William H Robinson, Matthew Budoff, Robert Detrano, Sabahat Bokhari, Joan M Bathon
OBJECTIVE: Citrullinated proteins have been found within atherosclerotic plaque. However, to date studies evaluating the association between anti-citrullinated peptide antibodies (ACPAs) and imaging measures of atherosclerosis in patients with rheumatoid arthritis (RA) have been limited to citrullinated-fibrinogen or citrullinated-vimentin seroreactivities and rendered contradictory results. Therefore, our objective was to evaluate this association using an extended panel of ACPAs in a larger sample of RA patients without clinical cardiovascular disease (CVD)...
October 1, 2016: Arthritis Care & Research
Erik P A van Iperen, Suthesh Sivapalaratnam, Michael V Holmes, G Kees Hovingh, Aeilko H Zwinderman, Folkert W Asselbergs
BACKGROUND AND AIMS: Type 2 diabetes (T2D), low-density lipoprotein-cholesterol (LDL-c), body mass index (BMI), blood pressure and smoking are established risk factors that play a causal role in coronary artery disease (CAD). Numerous common genetic variants associating with these and other risk factors have been identified, but their association with CAD has not been comprehensively examined in a single study. Our goal was to comprehensively evaluate the associations of established and emerging risk factors with CAD using genetic variants identified from Genome-wide Association Studies (GWAS)...
September 13, 2016: Atherosclerosis
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