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coronary artery calcification

Jan-Erik Guelker, Christian Blockhaus, Knut Kroeger, Rosemarie Wehner, Heinrich Klues, Alexander Bufe
Background: Failure of delivering a stent or a balloon across the target lesion during percutaneous coronary intervention (PCI) of chronic total occlusion (CTO), especially in arteries with calcified tortuous anatomy, is often due to insufficient backup support from the guiding catheter. The purpose of this study was to assess the feasibility of the GuideLiner (GL) catheter use. Methods: We examined 18 patients and used the GL catheter to overcome poor support and excessive friction in standardized antegrade and retrograde CTO procedures...
April 2018: Journal of the Saudi Heart Association
Sang-Eun Lee, Hyuk-Jae Chang, Ji Min Sung, Hyung-Bok Park, Ran Heo, Asim Rizvi, Fay Y Lin, Amit Kumar, Martin Hadamitzky, Yong Jin Kim, Edoardo Conte, Daniele Andreini, Gianluca Pontone, Matthew J Budoff, Ilan Gottlieb, Byoung Kwon Lee, Eun Ju Chun, Filippo Cademartiri, Erica Maffei, Hugo Marques, Jonathon A Leipsic, Sanghoon Shin, Jung Hyun Choi, Kavitha Chinnaiyan, Gilbert Raff, Renu Virmani, Habib Samady, Peter H Stone, Daniel S Berman, Jagat Narula, Leslee J Shaw, Jeroen J Bax, James K Min
OBJECTIVES: This study sought to describe the impact of statins on individual coronary atherosclerotic plaques. BACKGROUND: Although statins reduce the risk of major adverse cardiovascular events, their long-term effects on coronary atherosclerosis remain unclear. METHODS: We performed a prospective, multinational study consisting of a registry of consecutive patients without history of coronary artery disease who underwent serial coronary computed tomography angiography at an interscan interval of ≥2 years...
June 8, 2018: JACC. Cardiovascular Imaging
Zhuo Gao, Xiaomei Li, Jing Miao, Lide Lun
BACKGROUND: Secondary hyperparathyroidism (SHPT) and calcium and phosphorus metabolism disorder are important complications in haemodialysis patients. Parathyroidectomy (PTX) may prevent or delay the progress of vascular calcification in haemodialysis patients. OBJECTIVE: To investigate the impacts of PTX on calcium and phosphorus metabolism, arterial calcification and arterial stiffness in haemodialysis patients with SHPT. METHODS: Twenty-one SHPT-haemodialysis patients were selected for PTX...
June 13, 2018: Asian Journal of Surgery
Shaotao Zhang, Jiannan Dai, Haibo Jia, Sining Hu, Hongwei Du, Ning Li, Yongpeng Zou, Yanan Zou, Shenhong Jing, Yan Wang, Rong Sun, Bo Yu
BACKGROUND: Raised hemoglobinA1c (HbA1c) is an indicator of pre-diabetes, which is associated with increased risk of coronary artery disease. However, the detailed morphological characteristics of non-culprit plaques in acute coronary syndrome (ACS) patients remain largely unknown. METHODS: A total of 305 non-culprit plaques from 216 ACS patients were analyzed by intravascular optical coherence tomography. These patients were divided into three groups according to the serum glycosylated hemoglobin level: normal HbA1c (< 5...
June 15, 2018: Cardiovascular Diabetology
Shubei Zheng, Yu Zheng, Lingwei Jin, Zhihong Zhou, Zhanyuan Li
Background: We aimed to investigate the relationship between serum soluble Klotho protein (sKlotho) level and coronary artery calcification (CAC) as well as prognosis in patients with maintenance hemodialysis (MHD). Methods: Overall, 128 adult patients with end-stage renal failure treated with MHD were collected in the Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Zhejiang Province, China in 2013. Serum sKlotho was detected by ELISA and coronary artery calcification was measured by multi-slice spiral computed tomography (MSCT)...
April 2018: Iranian Journal of Public Health
Surya P Bhatt, Ella A Kazerooni, John D Newell, John E Hokanson, Matthew J Budoff, Chandra A Dass, Carlos H Martinez, Sandeep Bodduluri, Francine L Jacobson, Andrew Yen, Mark T Dransfield, Carl Fuhrman, Hrudaya Nath
BACKGROUND: COPD is associated with cardiovascular disease (CVD), and coronary artery calcification (CAC) provides additional prognostic information. With increasing use of non-gated CT scans in clinical practice, we hypothesized that the visual Weston CAC score would perform as well as Agatston score in predicting prevalent and incident coronary artery (CAD) and CVD in COPD. METHODS: We measured CAC using Agatston and Weston scores on baseline CT scans in 1875 current and former smokers enrolled in the COPDGene study...
June 8, 2018: Chest
Kipp W Johnson, Joel T Dudley, Jason R Bobe
Familial hypercholesterolemia (FH) is a genetic disease associated with persistently elevated levels of low-density lipoprotein cholesterol (LDL-C), which ultimately leads to greatly increased rates of atherosclerosis and cardiovascular disease. Atherosclerosis progression can be clinically approximated through measurement of coronary artery calcification (CAC). CAC can be measured via electron beam computed tomography (EBCT), multi-slice computed tomography (MSCT), or contrast-enhanced CT coronary angiography (CTCA)...
April 9, 2018: Curēus
Bernd Kowall
No abstract text is available yet for this article.
September 1, 2018: International Journal of Cardiology
Ki-Bum Won, Donghee Han, Ji Hyun Lee, Sang-Eun Lee, Ji Min Sung, Su-Yeon Choi, Eun Ju Chun, Sung Hak Park, Hae-Won Han, Jidong Sung, Hae Ok Jung, Hyuk-Jae Chang
BACKGROUND: Data on the impact of optimal glycemic control (OGC) on the progression of coronary artery calcification, an important marker for future adverse cardiovascular events in individuals with diabetes are limited. METHODS: We investigated 1637 asymptomatic adults with diabetes (56 ± 8 years, 88.8% men) and no history of coronary artery disease or stroke, who underwent serial coronary artery calcium (CAC) screening. The median inter-scan period was 3...
September 1, 2018: International Journal of Cardiology
Xuezhi Jiang, Ragad Asmaro, David M O'Sullivan, Jaymin Modi, Elizabeth Budnik, Peter F Schnatz
OBJECTIVE: Depression has been suggested as a risk factor for coronary heart disease (CHD). However, whether the risk may be affected by age is unknown. We seek to assess the difference in long-term CHD risk between younger (<65) and older (≥65) women with depressive symptoms. METHODS: Between June and August 2004, 1995 women presenting for routine mammography were enrolled to the primary study on breast arterial calcification. In 2005 (year 2), each woman completed a validated depression screening questionnaire...
May 24, 2018: International Journal of Cardiology
Hemant Mahajan, Jina Choo, Kamal Masaki, Akira Fujiyoshi, Jingchuan Guo, Takashi Hisamatsu, Rhobert Evans, Siyi Shangguan, Bradley Willcox, Tomonori Okamura, Abhishek Vishnu, Emma Barinas-Mitchell, Vasudha Ahuja, Katsuyuki Miura, Lewis Kuller, Chol Shin, Hirotsugu Ueshima, Akira Sekikawa
Data presented in this article are supplementary data to our primary article 'Association of Alcohol Consumption and Aortic Calcification in Healthy Men Aged 40-49 Years for the ERA JUMP Study' [1]. In this article, we have presented supplementary tables showing the independent association of alcohol consumption with coronary artery calcification using Tobit conditional regression and ordinal logistic regression.
April 2018: Data in Brief
L Parker Gregg, Maria Clarissa Tio, Xilong Li, Beverley Adams-Huet, James A de Lemos, S Susan Hedayati
BACKGROUND: Monocyte chemoattractant protein-1 -(MCP-1), a marker of inflammation and monocyte recruitment to atherosclerotic plaques, is associated with cardiovascular (CV) outcomes in patients with acute coronary syndrome. Although plasma levels are elevated in chronic kidney disease (CKD), associations with reduced kidney function or outcomes in CKD have not been explored. METHODS: In this population-based, probability-sampled, longitudinal cohort of 3,257 participants, including 286 (8...
June 6, 2018: American Journal of Nephrology
Subba R Digumarthy, Ruben De Man, Rodrigo Canellas, Alexi Otrakji, Ge Wang, Mannudeep K Kalra
We hypothesized that severity of coronary artery calcification (CAC), emphysema, muscle mass, and fat attenuation can help predict mortality in patients with lung cancer participating in the National Lung Screening Trial (NLST). Following regulatory approval from the Cancer Data Access System (CDAS), all patients diagnosed with lung cancer at the time of the screening study were identified. These subjects were classified into two groups: survivors and nonsurvivors at the conclusion of the NLST trial. These groups were matched based on their age, gender, body mass index (BMI), smoking history, lung cancer stage, and survival time...
2018: Journal of Oncology
Chandana Shekar, Matthew Budoff
Coronary artery calcification(CAC) is reflective of atherosclerotic disease and incrementally predictive of future cardiovascular events, independent of traditional risk factors. Extra coronary calcium such as aortic valve calcification, which can be identified and quantified by Computed Tomography(CT) imaging, has shown to predict future cardiovascular events in both asymptomatic and symptomatic (ie - stable angina and acute coronary syndrome) settings. It has hence been a vital tool in studies involving new therapies for cardiovascular disease...
June 4, 2018: Expert Review of Cardiovascular Therapy
Takashi Hisamatsu, Katsuyuki Miura, Hisatomi Arima, Akira Fujiyoshi, Aya Kadota, Sayaka Kadowaki, Maryam Zaid, Naoko Miyagawa, Atsushi Satoh, Ayako Kunimura, Minoru Horie, Hirotsugu Ueshima
BACKGROUND: The mechanisms by which exercise reduces the risk of coronary heart disease remain poorly understood. Irisin, an exercise-induced polypeptide secreted from skeletal muscles, is proposed to potentially mediate beneficial effects of exercise, especially in metabolic regulation and development of atherosclerosis. We examined whether higher serum irisin levels are associated with lower prevalence and progression of coronary atherosclerosis. METHODS AND RESULTS: We performed a prospective, population-based study of Japanese men aged 40-79 years without known coronary heart disease...
May 23, 2018: International Journal of Cardiology
Kazuhiro Osawa, Rine Nakanishi, Robyn L McClelland, Joseph F Polak, Warrick Bishop, Ralph L Sacco, Indre Ceponiene, Negin Nezarat, Sina Rahmani, Hong Qi, Mitsuru Kanisawa, Matthew J Budoff
BACKGROUND AND AIMS: The association between minimally elevated coronary artery calcification (CAC) and cerebrovascular disease is not well known. We assessed whether individuals with minimal CAC (Agatston scores of 1-10) have higher ischemic stroke or transient ischemic attack (TIA) frequencies compared with those with no CAC. We also investigated the relative prevalence of carotid atherosclerosis in these two groups. METHODS: A total of 3924 participants from the Multi-Ethnic Study of Atherosclerosis (MESA) without previous cardiovascular events, including stroke, and with baseline CAC scores of 0-10 were followed for the occurrence of incident ischemic stroke/TIA...
May 17, 2018: Atherosclerosis
H H Zhang, X B Meng, W Y Wang, K Zhang, Y Qi, S M An, S Y Wang, J L Zheng, J Wu, Y Zhou, C Y Gao, Y D Tang
Objective: This cross-sectional study aimed to address the relationship between the volume of epicardial adipose tissue (EAT) with cardiovascular risk factors and coronary artery calcification(CAC) in the community residents. Methods: Individuals were recruited from the Jidong Community (Tangshan City, Northern China) which mainly comprised employees of the Jidong Co. Ltd. and their family members. From July 2013 to August 2014, 2 647 participants aged ≥40 years were included in this study. The volume of EAT and coronary artery calcification score (CAC score) were determined by a 64-slice CT...
May 24, 2018: Zhonghua Xin Xue Guan Bing za Zhi
Mattia Peyracchia, Giulia De Lio, Chiara Montrucchio, Pierluigi Omedè, Gabriella d'Ettore, Andrea Calcagno, Vincenzo Vullo, Enrico Cerrato, Mauro Pennacchi, Gennaro Sardella, Pravin Manga, Walter GrossoMarra, Francesco Vullo, Francesco Fedele, Giuseppe Biondi-Zoccai, Claudio Moretti, Ahmed Vachiat, Stefano Bonora, Mauro Rinaldi, Massimo Mancone, Fabrizio D'Ascenzo
BACKGROUND AND AIMS: The risk of recurrence of myocardial infarction (MI) in HIV patients presenting with acute coronary syndrome (ACS) is well known, but there is limited evidence about potential differences in coronary plaques compared to non-HIV patients. METHODS: In this multicenter case-control study, HIV patients presenting with ACS, with intravascular-ultrasound (IVUS) data, enrolled between February 2015 and June 2017, and undergoing highly active antiretroviral therapy (HAART), were retrospectively compared to non-HIV patients presenting with ACS, before and after propensity score with matching, randomly selected from included centers...
May 5, 2018: Atherosclerosis
Michael S Lee, Evan Shlofmitz, Gentian Lluri, Kyung Woo Park, John Hollowed, Richard Shlofmitz
OBJECTIVES: The aim of this study was to determine the clinical outcomes of patients with long, diffusely calcified coronary artery lesions who underwent orbital atherectomy. BACKGROUND: The presence of severe coronary artery calcification increases the complexity of percutaneous coronary intervention. Orbital atherectomy of long, diffusely calcified lesions may increase the risk of periprocedural angiographic complications. Furthermore, the rate of ischemic complications, including target-vessel revascularization (TVR), in these long, calcified lesions is historically high...
June 2018: Journal of Invasive Cardiology
Kamonwan Tangvoraphonkchai, Andrew Davenport
Magnesium is the most abundant intracellular divalent cation and essential for maintaining normal cellular physiology and metabolism, acting as a cofactor of numerous enzymes, regulating ion channels and energy generation. In the heart, magnesium plays a key role in modulating neuronal excitation, intracardiac conduction, and myocardial contraction by regulating a number of ion transporters, including potassium and calcium channels. Magnesium also has a role in regulating vascular tone, atherogenesis and thrombosis, vascular calcification, and proliferation and migration of endothelial and vascular smooth muscle cells...
May 2018: Advances in Chronic Kidney Disease
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