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coronary artery calcification

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https://www.readbyqxmd.com/read/29454531/orbital-atherectomy-for-the-treatment-of-small-2-5mm-severely-calcified-coronary-lesions-orbit-ii-sub-analysis
#1
Michael S Lee, Richard A Shlofmitz, Evan Shlofmitz, Pratyaksh K Srivastava, Jeremy Kong, Cindy Grines, George Revytak, Jeffrey W Chambers
OBJECTIVES: We assessed the safety and efficacy of orbital atherectomy to modify severely calcified coronary plaque prior to stent implantation in patients with small vessel (2.5mm) disease. BACKGROUND: Severe coronary artery calcification increases the risk of adverse clinical events during percutaneous coronary intervention (PCI). Patients who undergo PCI of small vessels have worse clinical outcomes including higher rates of perforation and dissection. The outcomes of orbital atherectomy of small diameter vessels (2...
October 3, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29452856/generalized-cardiovascular-disease-on-a-preoperative-ct-scan-is-predictive-for-anastomotic-leakage-after-esophagectomy
#2
Alicia S Borggreve, Lucas Goense, Peter S N van Rossum, Richard van Hillegersberg, Pim A de Jong, Jelle P Ruurda
BACKGROUND: Recent studies demonstrated that calcification of arteries supplying the gastric tube is associated with anastomotic leakage after esophagectomy. However, it remains unclear whether this association only derives from local flow limitations, or generalized vascular disease as well. The purpose of this study was to determine whether calcification throughout the entire cardiovascular system is associated with anastomotic leakage. METHODS: Consecutive patients who underwent an esophagectomy with gastric tube reconstruction and cervical anastomosis for esophageal cancer were analyzed...
February 2, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29446834/the-hdl-anti-inflammatory-function-is-impaired-in-the-context-of-low-normal-free-thyroxine-in-diabetic-and-non-diabetic-individuals
#3
Lynnda J N van Tienhoven-Wind, Uwe J F Tietge, Robin P F Dullaart
Differences in thyroid function status within the euthyroid range have been proposed to affect the development of (subclinical) atherosclerosis [1], as evidenced by a greater carotid artery intima media thickness and progression of coronary artery calcification in the context of low normal thyroid function, i.e. a higher thyroid stimulating hormone (TSH) or a lower free thyroxine (FT4) thyroid hormone in the euthyroid range [2,3]. Importantly, with respect to high density lipoproteins (HDL) the concept is emerging that abnormalities in function rather than low concentrations of HDL cholesterol per se may give rise to impaired atheroprotective potential of this lipoprotein fraction...
February 15, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29444778/efficacy-and-safety-of-the-shexiang-baoxin-pill-for-the-treatment-of-coronary-artery-disease-not-amenable-to-revascularisation-study-protocol-for-a-randomised-placebo-controlled-double-blinded-trial
#4
Pan-Pan Tian, Jun Li, Jian Gao, Ying Li
INTRODUCTION: Coronary artery disease (CAD) not amenable to revascularisation indicates that the coronary arteries have severe diffuse lesions or calcifications, or that CAD is complicated with severe multiple-organ disease. Currently, Western medicines available for the treatment of CAD not amenable to revascularisation are limited. Shexiang Baoxin Pill (SBP), a type of Chinese patent medicine, has been widely used to treat CAD in China for many years. Previous studies have shown that long-term administration of SBP (1-2 pills three times daily, for at least 6 months) for treatment of CAD is effective and safe, with a significant, long-term effect...
February 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29439739/sex-difference-in-clot-lysability-and-association-to-coronary-artery-calcification
#5
Ramshanker Ramanathan, Niels Peter R Sand, Johannes J Sidelmann, Bjarne L Nørgaard, Jørgen B Gram
BACKGROUND: Incidence and prevalence of cardiovascular disease (CVD) differ between sexes, and women experience CVD later than men. Changes in fibrin clot lysability are associated with CVD, and the present study addresses sex differences in fibrin clot lysability in asymptomatic middle-aged individuals and the relation to coronary artery calcification (CAC). METHODS: Participants free of morbidities and medication, N = 163, were randomly chosen from a national registry among citizens, 50 or 60 years of age, and were followed for 5 years...
February 13, 2018: Biology of Sex Differences
https://www.readbyqxmd.com/read/29432400/treatment-of-coronary-artery-disease-with-a-new-generation-drug-coated-balloon-final-results-of-the-italian-elutax-sv-registry-dcb-rise
#6
Bernardo Cortese, Fabrizio D'Ascenzo, Raffaela Fetiveau, Vruyr Balian, Simonetta Blengino, Massimo Fineschi, Renata Rogacka, Corrado Lettieri, Andrea Pavei, Maurizio D'Amico, Arnaldo Poli, Gaetano Di Palma, Roberto A Latini, Pedro S Orrego, Romano Seregni
AIMS: Drug-coated balloons (DCBs) are a recognized alternative to stents for the treatment of in-stent restenosis (ISR), and there is some initial clinical evidence about their efficacy for the treatment of small coronary vessels. Newer-generation DCBs were developed to overcome the reduced deliverability of the previous generation, also warranting a more effective drug delivery to vessel wall. However, the vast majority of new-generation DCBs still lack of reliability due to paucity of clinical data...
February 9, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29409332/radial-artery-calcification-in-a-young-coronary-bypass-patient-a-caution
#7
Tanveer Ahmad, Kulasekaran Marimuthu, Kottoorathu Mammen Cherian
No abstract text is available yet for this article.
January 1, 2018: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/29408789/automatic-calcium-scoring-in-low-dose-chest-ct-using-deep-neural-networks-with-dilated-convolutions
#8
Nikolas Lessmann, Bram van Ginneken, Majd Zreik, Pim A de Jong, Bob D de Vos, Max A Viergever, Ivana Isgum
Heavy smokers undergoing screening with low-dose chest CT are affected by cardiovascular disease as much as by lung cancer. Low-dose chest CT scans acquired in screening enable quantification of atherosclerotic calcifications and thus enable identification of subjects at increased cardiovascular risk. This paper presents a method for automatic detection of coronary artery, thoracic aorta, and cardiac valve calcifications in low-dose chest CT using two consecutive convolutional neural networks. The first network identifies and labels potential calcifications according to their anatomical location and the second network identifies true calcifications among the detected candidates...
February 2018: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/29407888/inflammation-and-coronary-artery-calcification-in-south-asians-the-mediators-of-atherosclerosis-in-south-asians-living-in-america-masala-study
#9
Anurag Mehta, Jaideep Patel, Mahmoud Al Rifai, Colby R Ayers, Ian J Neeland, Alka M Kanaya, Namratha Kandula, Michael J Blaha, Khurram Nasir, Roger S Blumenthal, Parag H Joshi
BACKGROUND AND AIMS: Inflammatory biomarkers and adipocytokines (IBA) may contribute to atherosclerosis by promoting vascular inflammation. The association between IBA and coronary artery calcium (CAC), a marker of subclinical atherosclerosis, is not well defined in South Asians (SA). We hypothesized that IBA (high sensitivity C-reactive protein [hsCRP], tumor necrosis factor alpha [TNF-α], adiponectin, and leptin) were independently associated with and improved discrimination of CAC among SA...
January 29, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29405547/abdominal-aortic-calcification-score-predicts-the-occurrence-of-coronary-artery-disease-in-middle-aged-peritoneal-dialysis-patients
#10
Hung-Chih Chen, Che-Yi Chou, Hsuan-Jen Lin, Chiu-Ching Huang, Chiz-Tzung Chang
BACKGROUND: Abdominal aortic calcification (AAC) score in dialysis patients was associated with coronary artery disease (CAD) in cross-sectional study, but the use of AAC score in the CAD occurrence prediction was not clear. We aimed to use AAC score in the estimation of CAD occurrence in middle-aged peritoneal dialysis (PD) patients. METHODS: Middle-aged (45-65 years old) PD patients were recruited and followed up until CAD occurrence, patient mortality, or PD failure...
February 5, 2018: Nephrology
https://www.readbyqxmd.com/read/29404770/high-pitch-low-voltage-ct-coronary-artery-calcium-scoring-with-tin-filtration-accuracy-and-radiation-dose-reduction
#11
Georg Apfaltrer, Moritz H Albrecht, U Joseph Schoepf, Taylor M Duguay, Carlo N De Cecco, John W Nance, Domenico De Santis, Paul Apfaltrer, Marwen H Eid, Chelsea D Eason, Zachary M Thompson, Maximilian J Bauer, Akos Varga-Szemes, Brian E Jacobs, Erich Sorantin, Christian Tesche
OBJECTIVES: To investigate diagnostic accuracy and radiation dose of high-pitch CT coronary artery calcium scoring (CACS) with tin filtration (Sn100kVp) versus standard 120kVp high-pitch acquisition. METHODS: 78 patients (58% male, 61.5±9.1 years) were prospectively enrolled. Subjects underwent clinical 120kVp high-pitch CACS using third-generation dual-source CT followed by additional high-pitch Sn100kVp acquisition. Agatston scores, calcium volume scores, Agatston score categories, percentile-based risk categorization and radiation metrics were compared...
February 5, 2018: European Radiology
https://www.readbyqxmd.com/read/29402404/prognostic-value-of-supar-and-hs-crp-on-cardiovascular-disease
#12
Marie Zöga Diederichsen, Søren Zöga Diederichsen, Hans Mickley, Flemming Hald Steffensen, Jess Lambrechtsen, Niels Peter Rønnow Sand, Kent Lodberg Christensen, Michael Hecht Olsen, Axel Diederichsen, Mette Hjortdal Grønhøj
BACKGROUND AND AIMS: Studies have shown that soluble urokinase Plasminogen Activator Receptor (suPAR) and CRP (both inflammatory markers) and coronary artery calcification (CAC) are independent risk predictors for cardiovascular (CV) disease. The aim of this study is to assess whether suPAR and CRP have an increased predictive prognostic value beyond the traditional CV risk factors and the CAC score. METHODS: A population sample of 1179 subjects, free of CV disease was included...
January 31, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29393145/osteocardiology-defining-the-go-no-go-time-point-for-therapy
#13
Nalini M Rajamannan
Recent epidemiological studies have revealed that the risk factors associated with coronary artery calcification (CAC), including male gender, smoking, hypertension, and elevated serum cholesterol, are similar to the risk factors associated with the development of calcific aortic valve disease (CAVD). The results of the experimental and clinical studies demonstrate that traditional risk factors initiate early atherosclerosis which over time differentiates to form bone in the heart causing clinical CAC and CAVD...
January 27, 2018: Cardiology
https://www.readbyqxmd.com/read/29384880/risk-factors-for-heart-valve-calcification-in-chronic-kidney-disease
#14
Shu Rong, Xin Qiu, Xiucai Jin, Minghua Shang, Yixin Huang, Zhihuan Tang, Weijie Yuan
Cardiovascular disease (CVD) is a common cause of death in patients with chronic kidney disease (CKD). Aortic and mitral valve calcification (AVC and MVC, respectively) are critical indicators of CVD and all-cause mortality in CKD patients.We conducted a single center retrospective study of Chinese inpatients with CKD to identify risk factors associated with valve calcification (VC).Of 288 enrolled CKD patients, 22.9% had VC, all of which exhibited AVC, while 21.2% exhibited MVC. The VC group were significantly older than the non-VC group (70...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29383526/leveraging-the-coronary-calcium-scan-beyond-the-coronary-calcium-score
#15
REVIEW
Daniel Bos, Maarten J G Leening
Non-contrast cardiac computed tomography in order to obtain the coronary artery calcium score has become an established diagnostic procedure in the clinical setting, and is commonly employed in clinical and population-based research. This state-of-the-art review paper highlights the potential gain in information that can be obtained from the non-contrast coronary calcium scans without any necessary modifications to the scan protocol. This includes markers of cardio-metabolic health, such as the amount of epicardial fat and liver fat, but also markers of general health including bone density and lung density...
January 30, 2018: European Radiology
https://www.readbyqxmd.com/read/29378972/impact-of-the-use-of-intravascular-imaging-on-patients-who-underwent-orbital-atherectomy
#16
Michael S Lee, Evan Shlofmitz, Jeremy Kong, Gentian Lluri, Pratyaksh K Srivastava, Richard Shlofmitz
OBJECTIVES: We assessed the impact of intravascular ultrasound (IVUS)/optical coherence tomography (OCT) on outcomes of patients who underwent orbital atherectomy. BACKGROUND: Intravascular imaging provides enhanced lesion morphology assessment and optimization of percutaneous coronary intervention (PCI) outcomes. Severe coronary artery calcification increases the complexity of PCI and is associated with worse clinical outcomes. Orbital atherectomy modifies calcified plaque, facilitating stent delivery and optimizing stent expansion...
February 2018: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29374937/-optical-coherence-tomographic-analysis-of-in-stent-neoatherosclerosis-in-lesions-with-restenosis-after-drug-eluting-stent-implantation
#17
Z J Liu, B Shi, C C Deng, G X Xu, R Z Zhao, C Y Shen, Z L Wang, H L Liu
Objective: To explore the imaging characteristics and related influencing factors of in-stent neoatherosclerosis (ISNA) in patients with restenosis after drug-eluting stent(DES) implantation with optical coherence tomography(OCT). Methods: A total of 25 cases of coronary heart disease patients(DES placement time ≥8 months) with coronary artery angiography showing DES in-stent restenosis (ISR) in Zunyi medical college affiliated hospital from July 2013 to December 2015 were included in this study and patient's data were retrospectively analyzed...
January 24, 2018: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29368660/incidental-findings-in-ct-imaging-of-coronary-artery-bypass-grafts-results-from-a-canadian-multicenter-prospective-cohort
#18
I Boldeanu, J Perreault Bishop, S Nepveu, L-M Stevens, G Soulez, T M Kieser, A Lamy, N Noiseux, C Chartrand-Lefebvre
OBJECTIVE: To assess the prevalence and clinical significance of incidental findings identified during computed tomography imaging of coronary artery bypass grafts. RESULTS: This prospective study includes 144 patients undergoing coronary graft patency assessment using computed tomography. Incidental findings were classified as significant if they were considered to need an immediate action or treatment, short-term work-up or follow-up, or minor. A total of 211 incidental findings were present in 109 (75...
January 25, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29366052/pharmacogenetic-association-of-blood-lipid-related-genetic-variants-with-5-year-progression-of-coronary-artery-calcification-following-the-treatment-with-statin-in-the-heinz-nixdorf-recall-study
#19
Sonali Pechlivanis, Susanne Moebus, Nils Lehmann, Amir A Mahabadi, Iryna Dykun, Raimund Erbel, Karl-Heinz Jöckel, Markus M Nöthen, Hagen S Bachman
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29358042/determinants-of-high-device-cost-in-current-percutaneous-coronary-interventions
#20
Keisuke Hirai, Kenichi Sakakura, Yusuke Watanabe, Yousuke Taniguchi, Kei Yamamoto, Hiroshi Wada, Shin-Ichi Momomura, Hideo Fujita
BACKGROUND: Percutaneous coronary interventions (PCI), especially medical devices, consume large amounts of medical resources. It is important to know which type of lesions requires high device costs among current PCI. The purpose of this study was to investigate the association between lesion characteristics and medical device costs in current PCI. METHODS: We identified 593 coronary artery lesions in our PCI database between January 1, 2015 and December 31, 2015...
December 23, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
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