keyword
https://read.qxmd.com/read/38140657/phenotypical-screening-of-an-mmv-open-box-library-and-identification-of-compounds-with-antiviral-activity-against-st-louis-encephalitis-virus
#1
JOURNAL ARTICLE
Giuliana Eboli Sotorilli, Humberto Doriguetto Gravina, Ana Carolina de Carvalho, Jacqueline Farinha Shimizu, Marina Alves Fontoura, Talita Diniz Melo-Hanchuk, Artur Torres Cordeiro, Rafael Elias Marques
St. Louis encephalitis virus (SLEV) is a neglected mosquito-borne Flavivirus that may cause severe neurological disease in humans and other animals. There are no specific treatments against SLEV infection or disease approved for human use, and drug repurposing may represent an opportunity to accelerate the development of treatments against SLEV. Here we present a scalable, medium-throughput phenotypic cell culture-based screening assay on Vero CCL81 cells to identify bioactive compounds that could be repurposed against SLEV infection...
December 13, 2023: Viruses
https://read.qxmd.com/read/37925536/pharmacogenetic-and-clinical-predictors-of-voriconazole-concentration-in-hematopoietic-stem-cell-transplant-recipients-receiving-cyp2c19-guided-dosing
#2
JOURNAL ARTICLE
Jai N Patel, Myra Robinson, Sarah A Morris, Elizabeth Jandrisevits, Karine Eboli Lopes, Alicia Hamilton, Nury Steuerwald, Lawrence J Druhan, Belinda Avalos, Edward Copelan, Nilanjan Ghosh, Michael R Grunwald
CYP2C19-guided voriconazole dosing reduces pharmacokinetic variability, but many patients remain subtherapeutic. The aim of this study was to evaluate the effect of candidate genes and a novel CYP2C haplotype on voriconazole trough concentrations in patients receiving CYP2C19-guided dosing. This is a retrospective candidate gene study in allogeneic hematopoietic cell transplant (HCT) patients receiving CYP2C19-guided voriconazole dosing. Patients were genotyped for ABCB1, ABCG2, CYP2C9, CYP3A4, CYP3A5, and the CYP2C haplotype...
November 4, 2023: Pharmacogenomics Journal
https://read.qxmd.com/read/37387298/-school-based-screening-strategies-to-prevent-the-spread-of-covid-19-in-school-a-systematic-review-of-the-literature
#3
JOURNAL ARTICLE
Michele Marra, Michela Baccini, Giulia Cereda, Martina Culasso, Manuela De Sario, Ilenia Eboli, Alessio Lachi, Zuzana Mitrova, Rosella Saulle, Antonella Bena
OBJECTIVES: to describe studies that evaluated the screening programmes implemented in the school during the COVID-19 pandemic. DESIGN: a systematic literature review was conducted according to the PRISMA 2020 Guidelines. Studies published until December 2021 were included. The methodological quality of the studies was assessed with validated scales. Study selection, data extraction, and quality assessment were carried out by two authors independently. SETTING AND PARTICIPANTS: teachers and students belonging to schools of all levels, including universities...
2023: Epidemiologia e Prevenzione
https://read.qxmd.com/read/37240734/covid-19-and-health-outcomes-in-people-with-multiple-sclerosis-a-population-based-study-in-italy
#4
JOURNAL ARTICLE
Roberto Gnavi, Ilenia Eboli, Paolo Emilio Alboini, Sandra D'Alfonso, Roberta Picariello, Giuseppe Costa, Maurizio Leone
People with multiple sclerosis (PWMS) are at high risk of being affected by the disruption of health services that occurred during the COVID-19 pandemic months. The aim of this study was to evaluate the effect of the pandemic on the health outcomes of PWMS. PWMS and MS-free residing in Piedmont (north-west of Italy) were identified from electronic health records and linked with the regional COVID-19 database, the hospital-discharge database, and the population registry. Both cohorts (9333 PWMS and 4,145,856 MS-free persons) were followed-up for access to swab testing, hospitalisation, access to the Intensive Care Unit (ICU), and death from 22 February 2020 to 30 April 2021...
April 27, 2023: Life
https://read.qxmd.com/read/37235983/addressing-barriers-to-increased-adoption-of-dpyd-genotyping-at-a-large-multisite-cancer-center
#5
JOURNAL ARTICLE
Sarah A Morris, Donald C Moore, Laura W Musselwhite, Karine Eboli Lopes, Alicia Hamilton, Nury Steuerwald, Sarah L Hanson, Chris Larck, Kristen Swift, Mathew Smith, Kunal C Kadakia, Seungjean Chai, Jimmy J Hwang, Jai N Patel
DISCLAIMER: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. PURPOSE: To describe the implementation of an in-house genotyping program to detect genetic variants linked to impaired dihydropyrimidine dehydrogenase (DPD) metabolism at a large multisite cancer center, including barriers to implementation and mechanisms to overcome barriers to facilitate test adoption...
May 26, 2023: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/36794737/intracranial-solitary-fibrous-tumor-with-delayed-symptomatic-metastasis-to-the-lumbar-spine-illustrative-case
#6
JOURNAL ARTICLE
Simon A Menaker, Vladimir A Ljubimov, Viktoria O Krutikova, Cole Urnes, Serguei I Bannykh, Lindsey B Ross, Paula Eboli
BACKGROUND: Intracranial solitary fibrous tumors (SFTs), formerly known as hemangiopericytomas, are rare, aggressive mesenchymal extra-axial tumors typically treated via resection, often with preoperative embolization and postoperative radiation and/or antiangiogenic therapy. Although surgery confers a significant survival benefit, local recurrence and distant metastasis are not uncommon and may occur in a delayed fashion. OBSERVATIONS: The authors describe the case of a 29-year-old male who initially presented with headache, visual disturbance, and ataxia, and was found to have a large right tentorial lesion with mass effect on surrounding structures...
February 13, 2023: J Neurosurg Case Lessons
https://read.qxmd.com/read/35037358/seropositivity-for-cytomegalovirus-and-pcr-ebv-monitoring-protective-factors-for-posttransplant-lymphoproliferative-disorder-in-pediatric-liver-transplant
#7
JOURNAL ARTICLE
Lígia Patrícia de Carvalho Batista Éboli, Ana Cristina Aoun Tannuri, Uenis Tannuri
BACKGROUND: PTLD is a clinical condition with high mortality. Monitoring EBV replication can be a useful tool to avoid the development of PTLD. MATERIALS AND METHODS: This was a retrospective analysis of 428 pediatric patients who underwent liver transplantation between 1989 and 2016. The patients were divided into 2 groups (transplanted before 2006, when PCR-EBV was not monitored, and after 2006, when PCR-EBV monitoring was started). Patients with continuous PCR measurements for EBV were evaluated for the impact of a reduction in immunosuppression or a change in immunosuppressants on the number of viral copies...
June 2022: Pediatric Transplantation
https://read.qxmd.com/read/35010226/biochemical-characterization-of-traditional-varieties-of-apricots-prunus-armeniaca-l-of-the-campania-region-southern-italy
#8
JOURNAL ARTICLE
Florinda Fratianni, Antonio d'Acierno, Donatella Albanese, Marisa Di Matteo, Raffaele Coppola, Filomena Nazzaro
Campania is the most important region of Italy in the apricot cultivation, present mostly in the Vesuvio area. At least to the best of our knowledge, no studies are reporting the biochemical characterization of the considerable number of traditional apricot varieties present on this territory, including the qualitative and quantitative profile of the polyphenols present. Our work evaluated the content of β-carotene, total phenolics, phenolic profiles, ascorbic acid and antioxidant activity of 23 traditional varieties of apricots of the Campania region...
December 31, 2021: Foods (Basel, Switzerland)
https://read.qxmd.com/read/34948984/cycling-for-a-sustainable-touristic-mobility-a-preliminary-study-in-an-urban-area-of-italy
#9
JOURNAL ARTICLE
Gabriella Mazzulla, Maria Grazia Bellizzi, Laura Eboli, Carmen Forciniti
This study wants to give a contribution for the investigation of sustainable mobility with positive consequences on public health implementing policies starting from cyclists' perceptions. Data were collected by interviewing cyclists along three bike lanes of an urban area of southern Italy through a face-to-face survey. The survey was conducted in Autumn 2019, interviewing a sample of 129 cyclists. In order to identify the critical aspects of the bike paths, both an importance-performance analysis (IPA) and a gap-IPA were performed...
December 19, 2021: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/34766497/-scuola-sicura-a-school-screening-testing-programme-to-prevent-the-spread-of-covid-19-in-students-in-piedmont
#10
JOURNAL ARTICLE
Elena Farina, Ilenia Eboli, Teresa Spadea, Carlo Saugo, Lorenzo Richiardi, Milena Maule, Pietro Presti, Antonella Bena
BACKGROUND: 'Scuola sicura' (SS) programme aims to monitor the rate of COVID-19 and to contain its spread within the school population through early case isolation. OBJECTIVES: to describe the initial process and outcome evaluation results. DESIGN: descriptive study of an experimental screening testing programme in children in Piedmont Region (Northern Italy) in the period January-March 2021. The data used came from the COVID-19 platform and the Local Health Units, the archives of birth certificates (CedAP), and hospital discharge files (SDO)...
2021: Epidemiologia e Prevenzione
https://read.qxmd.com/read/34030497/the-role-of-single-nucleotide-polymorphisms-of-mirnas-100-and-146a-as-prognostic-factors-for-prostate-cancer
#11
JOURNAL ARTICLE
Juliana Alves de Camargo, Renan Eboli Lopes, Gabriel Fernandes Dias Ferreira, Nayara Izabel Viana, Vanessa Guimaraes, Kátia Ramos Moreira Leite, William C Nahas, Miguel Srougi, Alberto A Antunes, Sabrina T Reis
INTRODUCTION: Prostate cancer has a high incidence in men and is the second cause of cancer death among americans male. microRNA (miR) is becoming a potential new prognostic factor for prostate cancer. Single nucleotide polymorphisms (SNPs) are common polymorphisms, characterized by a single exchange of nitrogen based in the DNA. This polymorphism is present in the miRs, altering their function. OBJECTIVE: To evaluate the role of SNP rs1834306 of miR100 and rs2910164 of miR146a in the development and prognosis of prostate cancer...
June 2021: International Journal of Biological Markers
https://read.qxmd.com/read/33773049/functional-outcomes-of-pediatric-patients-in-short-term-pediatric-rehabilitation-intensive-therapy-sprint-while-receiving-acute-oncologic-and-hematologic-care
#12
JOURNAL ARTICLE
Elaine Tsao, Megan Flanigan, Lindsay Johnson, Melissa Toy, Eboli Giannini, Kristie Bjornson
BACKGROUND: Pediatric patients with oncologic and hematologic diagnoses who experience newly acquired functional deficits during a hospitalization may benefit from intensive therapies. However, acute medical issues or disease treatment plans may prevent a safe transfer to the inpatient rehabilitation unit. Accordingly, Short-term Pediatric Rehabilitation Intensive Therapy (SPRINT), a 2-week inpatient intensive therapy program, was developed for pediatric patients on an acute care service...
March 2022: PM & R: the Journal of Injury, Function, and Rehabilitation
https://read.qxmd.com/read/31783314/mucinous-breast-cancer-a-narrative-review-of-the-literature-and-a-retrospective-tertiary-single-centre-analysis
#13
REVIEW
Emilia Marrazzo, Federico Frusone, Flavio Milana, Andrea Sagona, Wolfgang Gatzemeier, Erika Barbieri, Alberto Bottini, Giuseppe Canavese, Arianna Olga Rubino, Marco Gaetano Eboli, Carlo Marco Rossetti, Alberto Testori, Valentina Errico, Alessandro De Luca, Corrado Tinterri
Mucinous carcinoma (MC) is a rare breast cancer characterized by the presence of large extracellular mucin amount. Two main subtypes can be distinguished: pure (PMC) and mixed (MMC). We conducted a retrospective MC analysis in our prospective maintained database, calculating disease-free survival (DFS) and 5-year overall survival (OS). We found a global 92.1% OS (higher in MMC group and statistically significative) and a DFS of 95.3% (higher in MMC group but not statistically significative).
February 2020: Breast: Official Journal of the European Society of Mastology
https://read.qxmd.com/read/28658403/dementia-and-legal-determination-of-capacity
#14
JOURNAL ARTICLE
Valeska Maria Eboli Bello Delineau, Rodrigo Rizek Schultz
OBJECTIVE: To assess the legal capacity and guardianship proceedings in patients diagnosed with dementia. METHODS: Ninety-seven patients diagnosed with dementia and seen at a tertiary hospital were evaluated. RESULTS: Of these 97 patients, 60 (62%) were female. The mean age of the patients was 77.9 years; average schooling was 5.5 years. The main diagnosis was Alzheimer's disease (73%): 16 patients were at a mild stage, eight at a moderate stage and 73 at an advanced stage of dementia...
June 2017: Arquivos de Neuro-psiquiatria
https://read.qxmd.com/read/28457406/comparison-of-the-results-of-living-donor-liver-transplantation-due-to-acute-liver-failure-and-biliary-atresia-in-a-quaternary-center
#15
COMPARATIVE STUDY
L Éboli, A C Tannuri, N Gibelli, T Silva, P Braga, U Tannuri
OBJECTIVE: The objective of this study was to compare the complications, outcomes, and survival prevalence in patients undergoing living donor liver transplantation due to biliary atresia (BA) or acute liver failure (ALF). RESULTS: In the period of June 1998-July 2016, 199 children underwent living transplantation due to BA or ALF. Of these 199, 184 were included in the analysis. The average age, weight, and body mass index of BA patients were lower than those of ALF (P < ...
May 2017: Transplantation Proceedings
https://read.qxmd.com/read/28076501/evaluating-the-best-time-to-intervene-acute-liver-failure-in-rat-models-induced-by-d-galactosamine
#16
JOURNAL ARTICLE
Lígia Patrícia de Carvalho Batista Éboli, Alcides Augusto Salzedas Netto, Ramiro Antero de Azevedo, Valéria Pereira Lanzoni, Tatiana Sugayama de Paula, Alberto Goldenberg, Adriano Miziara Gonzalez
PURPOSE: To describe an animal model for acute liver failure by intraperitoneal d-galactosamine injections in rats and to define when is the best time to intervene through King's College and Clichy´s criteria evaluation. METHODS: Sixty-one Wistar female rats were distributed into three groups: group 1 (11 rats received 1.4 g/kg of d-galactosamine intraperitoneally and were observed until they died); group 2 (44 rats received a dose of 1.4 g/kg of d-galactosamine and blood and histological samples were collected for analysis at 12 , 24, 48 , 72 and 120 hours after the injection); and the control group as well (6 rats) ...
December 2016: Acta Cirúrgica Brasileira
https://read.qxmd.com/read/27470467/quantification-of-viable-helminth-eggs-in-samples-of-sewage-sludge
#17
REVIEW
Maria Carolina Vieira da Rocha, Monica Eboly Barés, Maria Cristina Borba Braga
For the application of sewage sludge as fertilizer, it is of fundamental importance the absence of pathogenic organisms, such as viable helminth eggs. Thus, the quantification of these organisms has to be carried out by means of the application of reliable and accurate methodologies. Nevertheless, until the present date, there is no consensus with regard to the adoption of a universal methodology for the detection and quantification of viable helminth eggs. It is therefore necessary to instigate a debate on the different protocols currently in use, as well as to assemble relevant information in order to assist in the development of a more comprehensive and accurate method to quantify viable helminth eggs in samples of sewage sludge and its derivatives...
October 15, 2016: Water Research
https://read.qxmd.com/read/25568736/resting-metabolic-rate-analysis-in-chronic-hemiparesis-patients
#18
JOURNAL ARTICLE
Mauricio de Sant'Anna, Leonardo Coelho Eboli, Julio Guilherme Silva, Alan Gomes Dos Santos, Michele Lourenço, Adalgiza Mafra Moreno, Gabriel Rodriguez de Freitas, Marco Orsini
The objective of the present study was to compare resting metabolic rate (RMR) of chronic hemiparetic patients to sedentary health individuals. The sample was composed of 16 individuals, that were divided into two groups. The first group had eight hemiparetic patients and the second group was formed by eight sedentary individuals. To access and analyze the gases information a VO2000 analyzer was used. The following variables were measured: VO2, VCO2, VE, QR, grams of fat (GrFAT), grams of carbohydrate. RMR was calculated based on Weir's equation...
October 23, 2014: Neurology International
https://read.qxmd.com/read/25478572/differentiation-of-benign-angiomatous-and-microcystic-meningiomas-with-extensive-peritumoral-edema-from-high-grade-meningiomas-with-aid-of-diffusion-weighted-mri
#19
JOURNAL ARTICLE
Avetis Azizyan, Paula Eboli, Doniel Drazin, James Mirocha, Marcel M Maya, Serguei Bannykh
OBJECTIVE: To determine whether angiomatous and microcystic meningiomas which mimic high grade meningiomas based on extent of peritumoral edema can be reliably differentiated as low grade tumors using normalized apparent diffusion coefficient (ADC) values. METHODS: Preoperative magnetic resonance imaging (MRI) of seventy patients with meningiomas was reviewed. Morphologically, the tumors were divided into 3 groups. Group 1 contained 12 pure microcystic, 3 pure angiomatoid and 7 mixed angiomatoid and microcystic tumors...
2014: BioMed Research International
https://read.qxmd.com/read/25247553/how-to-identify-the-key-factors-that-affect-driver-perception-of-accident-risk-a-comparison-between-italian-and-spanish-driver-behavior
#20
COMPARATIVE STUDY
Juan de Oña, Rocio de Oña, Laura Eboli, Carmen Forciniti, Gabriella Mazzulla
Road crashes can be caused by different factors, including infrastructure, vehicles, and human variables. Many research studies have focused solely on identifying the key factors that cause road crashes. From these studies, it emerged that human factors have the most relevant impact on accident severity. More specifically, accident severity depends on several factors related directly to the driver, i.e., driving experience, driver's socio-economic characteristics, and driving behavior and attitudes. In this paper, we investigate driver behaviors and attitudes while driving and specifically focus on different methods for identifying the factors that most affect the driver's perception of accident risk...
December 2014: Accident; Analysis and Prevention
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