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Schizophrenia sleep

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https://www.readbyqxmd.com/read/28792954/variants-in-calcium-voltage-gated-channel-subunit-alpha1-c-gene-cacna1c-are-associated-with-sleep-latency-in-infants
#1
Katri Kantojärvi, Johanna Liuhanen, Outi Saarenpää-Heikkilä, Anna-Liisa Satomaa, Anneli Kylliäinen, Pirjo Pölkki, Julia Jaatela, Auli Toivola, Lili Milani, Sari-Leena Himanen, Tarja Porkka-Heiskanen, Juulia Paavonen, Tiina Paunio
Genetic variants in CACNA1C (calcium voltage-gated channel subunit alpha1 C) are associated with bipolar disorder and schizophrenia where sleep disturbances are common. In an experimental model, Cacna1c has been found to modulate the electrophysiological architecture of sleep. There are strong genetic influences for consolidation of sleep in infancy, but only a few studies have thus far researched the genetic factors underlying the process. We hypothesized that genetic variants in CACNA1C affect the regulation of sleep in early development...
2017: PloS One
https://www.readbyqxmd.com/read/28736215/human-ipsc-glial-mouse-chimeras-reveal-glial-contributions-to-schizophrenia
#2
Martha S Windrem, Mikhail Osipovitch, Zhengshan Liu, Janna Bates, Devin Chandler-Militello, Lisa Zou, Jared Munir, Steven Schanz, Katherine McCoy, Robert H Miller, Su Wang, Maiken Nedergaard, Robert L Findling, Paul J Tesar, Steven A Goldman
In this study, we investigated whether intrinsic glial dysfunction contributes to the pathogenesis of schizophrenia (SCZ). Our approach was to establish humanized glial chimeric mice using glial progenitor cells (GPCs) produced from induced pluripotent stem cells derived from patients with childhood-onset SCZ. After neonatal implantation into myelin-deficient shiverer mice, SCZ GPCs showed premature migration into the cortex, leading to reduced white matter expansion and hypomyelination relative to controls...
August 3, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28720848/the-natural-disc1-deletion-present-in-several-inbred-mouse-strains-does-not-affect-sleep
#3
Lars Dittrich, Alessandro Petese, Walker S Jackson
The gene Disrupted in Schizophrenia-1 (DISC1) is linked to a range of psychiatric disorders. Two recent transgenic studies suggest DISC1 is also involved in homeostatic sleep regulation. Several strains of inbred mice commonly used for genome manipulation experiments, including several Swiss and likely all 129 substrains, carry a natural deletion mutation of Disc1. This constitutes a potential confound for studying sleep in genetically modified mice. Since disturbed sleep can also influence psychiatric and neurodegenerative disease models, this putative confound might affect a wide range of studies in several fields...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28714081/combining-two-model-systems-of-psychosis-the-effects-of-schizotypy-and-sleep-deprivation-on-oculomotor-control-and-psychotomimetic-states
#4
Inga Meyhöfer, Maria Steffens, Eliana Faiola, Anna-Maria Kasparbauer, Veena Kumari, Ulrich Ettinger
Model systems of psychosis, such as schizotypy or sleep deprivation, are valuable in informing our understanding of the etiology of the disorder and aiding the development of new treatments. Schizophrenia patients, high schizotypes, and sleep-deprived subjects are known to share deficits in oculomotor biomarkers. Here, we aimed to further validate the schizotypy and sleep deprivation models and investigated, for the first time, their interactive effects on smooth pursuit eye movements (SPEM), prosaccades, antisaccades, predictive saccades, and measures of psychotomimetic states, anxiety, depression, and stress...
July 17, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28711475/the-interaction-between-subclinical-psychotic-experiences-insomnia-and-objective-measures-of-sleep
#5
Jan Cosgrave, Ross Haines, Dalena van Heugten-van der Kloet, Ross Purple, Kate Porcheret, Russell Foster, Katharina Wulff
Investigations into schizophrenia have revealed a high incidence of comorbidity with disturbed sleep and circadian timing. Acknowledging this comorbidity on a dimensional level, we tested prospectively whether subclinical psychotic symptoms are more prevalent in individuals with insomnia. An insomnia group (n=21) and controls (n=22) were recruited on their subjective sleep quality, recorded actigraphically for 3weeks and assessed for psychotic-like experiences with The Prodromal Questionnaire-16. Using multivariate Poisson regression analyses, we found that objective and subjective sleep measures interact to predict the highest risk for psychotic experiences...
July 12, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28686934/z-drug-for-schizophrenia-a-systematic-review-and-meta-analysis
#6
Taro Kishi, Ken Inada, Yuki Matsui, Nakao Iwata
No systematic reviews and meta-analyses on the use of Z-drug for schizophrenia are available. Randomized, placebo-controlled, or non-pharmacological intervention-controlled trials published before 03/20/2017 were retrieved from major healthcare databases and clinical trial registries. A meta-analysis including only randomized, placebo-controlled trials was performed. Efficacy outcomes were measured as improvement in overall schizophrenia symptoms, total sleep time, and wake after sleep onset. Safety/acceptability outcomes were discontinuation rate and individual adverse events...
June 17, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28666896/circadian-neurons-in-the-lateral-habenula-clocking-motivated-behaviors
#7
REVIEW
Jorge Mendoza
The main circadian clock in mammals is located in the hypothalamic suprachiasmatic nucleus (SCN), however, central timing mechanisms are also present in other brain structures beyond the SCN. The lateral habenula (LHb), known for its important role in the regulation of the monoaminergic system, contains such a circadian clock whose molecular and cellular mechanisms as well as functional role are not well known. However, since monoaminergic systems show circadian activity, it is possible that the LHb-clock's role is to modulate the rhythmic activity of the dopamine, serotonin and norephinephrine systems, and associated behaviors...
June 28, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28647492/eszopiclone-for-persistent-negative-symptoms-in-schizophrenia-an-unintended-n-of-1-study
#8
Urvakhsh Meherwan Mehta, Vinutha Ravishankar, Jagadisha Thirthalli
Persistent negative and cognitive symptoms in patients with schizophrenia pose a significant challenge to clinicians. Being a heterogeneous cluster of symptoms with potentially distinct underlying pathogenesis, it is important to examine novel therapies based on emerging neurobiological evidence. Eszopiclone is known to enhance the deficient sleep spindles that are related to impairments in learning and memory in schizophrenia. In this report we highlight the potential utility of eszopiclone in treating persistent negative symptoms in a patient with chronic schizophrenia...
June 21, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28640657/retinal-findings-on-oct-in-systemic-conditions
#9
Preeti Patil Chhablani, Vikas Ambiya, Akshay G Nair, Sailaja Bondalapati, Jay Chhablani
PURPOSE: Imaging technology has advanced by leaps and bounds in the recent past and has resulted in a much greater understanding of ocular diseases. The aim of this review article is to summarize optical coherence tomography (OCT) findings of various systemic conditions. METHOD: A systematic literature search of the Medline/PubMed database was performed. English articles up to April 2015 were included. Terms used for search included: Alzheimer's Disease; Multiple Sclerosis; Parkinson's Disease; Behçet's Disease; Schizophrenia; Migraine; Obstructive Sleep Apnea Syndrome; Neurofibromatosis; Sickle Cell Disease; Renal diseases; Lupus Retinopathy; Valsalva Retinopathy; Whiplash Retinopathy; Shaken-Baby Syndrome; Choroidal metastases; Intracranial Hypertension; Drug toxicity; Deferoxamine; Sildenafil; Tamoxifen; Hydroxychloroquine; Chloroquine; Ethambutol; Lead; Sickle Cell Disease; and Thalassemia along with OCT...
June 22, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28637633/physical-activity-correlates-among-people-with-psychosis-data-from-47-low-and-middle-income-countries
#10
Brendon Stubbs, Davy Vancampfort, Joseph Firth, Mats Hallgren, Felipe Schuch, Nicola Veronese, Marco Solmi, Fiona Gaughran, Kai G Kahl, Simon Rosenbaum, Philip B Ward, Andre F Carvalho, Ai Koyanagi
BACKGROUND: People with schizophrenia engage in low levels of physical activity (PA). However, few large-scale studies have investigated the factors that may influence PA participation in individuals with psychosis and data from low- and middle-income countries (LMICs) is especially scarce. Thus, we investigated PA correlates in a large sample of people with a psychosis diagnosis across 47 LMICs. METHODS: Cross-sectional data from the World Health Survey, restricting to those with a self-reported lifetime diagnosis of schizophrenia/psychotic disorder, was analyzed...
June 18, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28633578/the-imperative-to-screen-for-obstructive-sleep-apnoea-in-people-with-schizophrenia
#11
Stephen Parker, Bradford Johnston, Abigail Lane, Frances Dark, Dan Siskind
No abstract text is available yet for this article.
July 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28599949/quetiapine-extended-release-versus-aripiprazole-in-children-and-adolescents-with-first-episode-psychosis-the-multicentre-double-blind-randomised-tolerability-and-efficacy-of-antipsychotics-tea-trial
#12
Anne Katrine Pagsberg, Pia Jeppesen, Dea Gowers Klauber, Karsten Gjessing Jensen, Ditte Rudå, Marie Stentebjerg-Olesen, Peter Jantzen, Simone Rasmussen, Eva Ann-Sofie Saldeen, Maj-Britt Glenn Lauritsen, Niels Bilenberg, Anne Dorte Stenstrøm, Louise Nyvang, Sarah Madsen, Thomas M Werge, Theis Lange, Christian Gluud, Maria Skoog, Per Winkel, Jens Richardt M Jepsen, Birgitte Fagerlund, Christoph U Correll, Anders Fink-Jensen
BACKGROUND: Head-to-head trials to guide antipsychotic treatment choices for paediatric psychosis are urgently needed because extrapolations from adult studies might not be implementable. In this superiority trial with two-sided significance testing, we aimed to compare the efficacy and safety of quetiapine-extended release (quetiapine-ER) versus aripiprazole in children and adolescents with first-episode psychosis, to determine whether differences between the two treatments were sufficient to guide clinicians in their choice of one drug over the other...
August 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28574288/chronotype-and-its-relationship-with-sleep-disorders-in-children-with-attention-deficit-hyperactivity-disorder
#13
Fatma Benk Durmuş, Ayşe Rodopman Arman, Ayşe Burcu Ayaz
Chronotype can be classified as morningness types, people who prefer morning hours for their physical and mental activities; eveningness types, people who prefer the afternoon or evening hours; and intermediate types, those who show characteristics of both morningness and eveningness types. Attention deficit hyperactivity disorder (ADHD) has been linked with disturbances in chronotype, particularly increased eveningness. Despite the possibility of an association between chronotypes, sleep disturbances and ADHD symptoms, there is little evidence of this association considering the child population...
June 2, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28549429/sleep-characteristics-in-child-and-adolescent-offspring-of-parents-with-bipolar-disorder-a-case-control-study
#14
Antonin Sebela, Tomas Novak, David Kemlink, Michal Goetz
BACKGROUND: Impairment of sleep and circadian rhythm is a typical feature of bipolar disorder (BD). We carried out an exploratory cross-sectional case-control study to extend the knowledge of sleep characteristics in offspring at risk for BD. METHODS: We investigated 42 offspring of bipolar parents (OB) (mean age 12.5 ± 3.2) and 42 sex and age matched comparison offspring of healthy parents. We administered the Pediatric Sleep Questionnaire, the Morningness/Eveningness Questionnaire and The General Behavior Inventory Sleep Subscale (GBISS) to assess circadian preference, and to identify sleep impairment symptoms...
May 26, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28503978/comparison-of-depression-symptoms-between-primary-depression-and-secondary-to-schizophrenia-depression
#15
Twana Rahim, Roshe Rashid
OBJECTIVES: This study exclusively aimed to clinically assess which symptom pattern discriminates primary depression from depression-secondary to-schizophrenia. METHODS: A total of 98 patients with primary depression and 71 patients with secondary-to-schizophrenia depression were assessed for identifying the clinical phenomena of depression. Diagnosis of schizophrenia was confirmed by Mini International Neuropsychiatric Interview. Each participant was, however, assessed by Patient Health Questionnaire-9 as well as Calgary Depression Scale for Schizophrenia (CDSS) for possible concurrent depressive symptoms...
May 15, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28487157/cerebrovascular-reactivity-measured-by-functional-magnetic-resonance-imaging-during-breath-hold-challenge-a-systematic-review
#16
REVIEW
Adam L Urback, Bradley J MacIntosh, Benjamin I Goldstein
Cerebrovascular reactivity (CVR) is the cerebral hemodynamic response to a vasoactive substance. Breath-hold (BH) induced CVR has the advantage of being non-invasive and easy to implement during magnetic resonance imaging (MRI). We systematically reviewed the literature regarding MRI measurement of BH induced CVR. The literature was searched using MEDLINE with the search terms breath-hold; and MRI or cerebrovascular reactivity. The search yielded 2244 results and 54 articles were included. Between-group comparisons have found that CVR was higher among healthy controls than patients with various pathologies (e...
August 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28483271/-mindful-neuropsychology-mindfulness-based-cognitive-remediation
#17
E Bulzacka, S Lavault, A Pelissolo, C Bagnis Isnard
OBJECTIVES: Mindfulness based interventions (MBI) have recently gained much interest in western medicine. MBSR paradigm is based on teaching participants to pay complete attention to the present experience and act nonjudgmentally towards stressful events. During this mental practice the meditator focuses his or her attention on the sensations of the body. While the distractions (mental images, thoughts, emotional or somatic states) arise the participant is taught to acknowledge discursive thoughts and cultivate the state of awareness without immediate reaction...
May 5, 2017: L'Encéphale
https://www.readbyqxmd.com/read/28479324/theta-oscillations-during-active-sleep-synchronize-the-developing-rubro-hippocampal-sensorimotor-network
#18
Carlos Del Rio-Bermudez, Jangjin Kim, Greta Sokoloff, Mark S Blumberg
Neuronal oscillations comprise a fundamental mechanism by which distant neural structures establish and express functional connectivity. Long-range functional connectivity between the hippocampus and other forebrain structures is enabled by theta oscillations. Here, we show for the first time that the infant rat red nucleus (RN)-a brainstem sensorimotor structure-exhibits theta (4-7 Hz) oscillations restricted primarily to periods of active (REM) sleep. At postnatal day 8 (P8), theta is expressed as brief bursts immediately following myoclonic twitches; by P12, theta oscillations are expressed continuously across bouts of active sleep...
May 22, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28479102/septal-cholinergic-neuromodulation-tunes-the-astrocyte-dependent-gating-of-hippocampal-nmda-receptors-to-wakefulness
#19
Thomas Papouin, Jaclyn M Dunphy, Michaela Tolman, Kelly T Dineley, Philip G Haydon
The activation of the N-methyl D-aspartate receptor (NMDAR) is controlled by a glutamate-binding site and a distinct, independently regulated, co-agonist-binding site. In most brain regions, the NMDAR co-agonist is the astrocyte-derived gliotransmitter D-serine. We found that D-serine levels oscillate in mouse hippocampus as a function of wakefulness, in vitro and in vivo. This causes a full saturation of the NMDAR co-agonist site in the dark (active) phase that dissipates to sub-saturating levels during the light (sleep) phase, and influences learning performance throughout the day...
May 17, 2017: Neuron
https://www.readbyqxmd.com/read/28468274/clock-genes-and-altered-sleep-wake-rhythms-their-role-in-the-development-of-psychiatric-disorders
#20
Annaëlle Charrier, Bertrand Olliac, Pierre Roubertoux, Sylvie Tordjman
In mammals, the circadian clocks network (central and peripheral oscillators) controls circadian rhythms and orchestrates the expression of a range of downstream genes, allowing the organism to anticipate and adapt to environmental changes. Beyond their role in circadian rhythms, several studies have highlighted that circadian clock genes may have a more widespread physiological effect on cognition, mood, and reward-related behaviors. Furthermore, single nucleotide polymorphisms in core circadian clock genes have been associated with psychiatric disorders (such as autism spectrum disorder, schizophrenia, anxiety disorders, major depressive disorder, bipolar disorder, and attention deficit hyperactivity disorder)...
April 29, 2017: International Journal of Molecular Sciences
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