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Chronic Resynchronization Therapy

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https://www.readbyqxmd.com/read/28641292/the-incidence-clinical-significance-and-treatment-effects-of-depression-in-cardiac-resynchronization-therapy-recipients
#1
Tomasz Podolecki, Robert Pudlo, Michal Mazurek, Monika Koziel, Ewa Jedrzejczyk-Patej, Joanna Boidol, Katarzyna Przybylska, Adam Sokal, Oskar Kowalski, Jacek Kowalczyk, Radoslaw Lenarczyk, Zbigniew Kalarus
OBJECTIVES: Chronic heart failure (HF) is associated with significantly increased prevalence of depression. The aim of the study was to assess the incidence and clinical impact of depression as well as the effectiveness of depression treatment in HF patients. METHODS: A prospective interventional trial included 285 consecutive cardiac resynchronization therapy recipients. Patients underwent a psychiatric examination at the time of implantation and then it was routinely repeated at 3, 6, and 12 months after the procedure, and every 6 months thereafter...
June 23, 2017: Cardiology
https://www.readbyqxmd.com/read/28602366/treatment-of-heart-failure-with-abnormal-left-ventricular-systolic-function-in-older-adults
#2
REVIEW
Wilbert S Aronow
Heart failure (HF) with abnormal left ventricular (LV) ejection fraction should be identified and treated. Treat hypertension with diuretics, angiotensin-converting enzyme (ACE) inhibitors, and β-blockers. Treat myocardial ischemia with nitrates and β-blockers. Treat volume overload and HF with diuretics. Treat HF with ACE inhibitors and β-blockers. Sacubitril/valsartan may be used instead of an ACE inhibitor or ARB in chronic symptomatic HF and abnormal LV ejection fraction. Add isosorbide dinitrate/hydralazine in African Americans with class II to IV HF treated with diuretics, ACE inhibitors, and β-blockers...
July 2017: Heart Failure Clinics
https://www.readbyqxmd.com/read/28569386/risk-score-to-assess-mortality-risk-in-patients-undergoing-transvenous-lead-extraction
#3
Ewa Oszczygieł, Andrzej Kutarski, Andrzej Oszczygieł, Beata Mańkowska-Załuska, Michał Chudzik, Jerzy Krzysztof Wranicz, Iwona Cygankiewicz
AIMS: The main aim of a study was to assess one-year mortality and its predictors in a cohort of patients who underwent transvenous lead extraction (TLE) procedure. METHODS: Retrospective analysis of clinical characteristics and 1-year follow up of patients referred for a TLE procedure in a single high volume center between June 2006 and October 2014 was performed. RESULTS: The studied population included 130 patients (82 males; mean age 64 ±15 years) implanted with pacemakers (74%), implantable cardioverter defibrillators (15%), or cardiac resynchronization therapy defibrillator (11%)...
June 1, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28554585/predictors-of-response-to-cardiac-resynchronization-therapy-a-prospective-cohort-study
#4
Ana Abreu, Mário Oliveira, Pedro Silva Cunha, Helena Santa Clara, Vanessa Santos, Guilherme Portugal, Pedro Rio, Rui Soares, Luísa Moura Branco, Marta Alves, Ana Luísa Papoila, Rui Ferreira, Miguel Mota Carmo
INTRODUCTION: Cardiac resynchronization therapy (CRT) has modified the prognosis of chronic heart failure (HF) with left ventricular systolic dysfunction. However, 30% of patients do not have a favorable response. The big question is how to determine predictors of response. AIMS: To identify baseline characteristics that might influence echocardiographic response to CRT. METHODS AND RESULTS: We performed a prospective single-center hospital-based cohort study of consecutive HF patients selected to CRT (NYHA class II-IV, left ventricular ejection fraction (LVEF) <35% and QRS complex ≥120 ms)...
May 26, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/28545627/impact-of-renal-function-on-survival-after-cardiac-resynchronization-therapy
#5
J Alvin Kpaeyeh, Laura Divoky, J Madison Hyer, David D Daly, Anbukarasi Maran, Ashley Waring, Michael R Gold
Chronic kidney disease (CKD) is associated with worse survival in patients with heart disease including those with implantable devices. Cardiac resynchronization therapy (CRT) can potentially improve renal function. To assess the relation between the change in renal function and survival with CRT, 238 patients undergoing initial CRT with defibrillator implantation between 2002 and 2011 were followed. The primary end point was all-cause mortality. The estimated glomerular filtration rate (eGFR), before implantation and 6 ± 3 months after CRT was calculated...
July 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28471545/eleven-year-trends-of-inpatient-pacemaker-implantation-in-patients-diagnosed-with-sick-sinus-syndrome
#6
Avirup Guha, Xiao Xiang, Devin Haddad, Benjamin Buck, Xu Gao, Michael Dunleavy, Ellen Liu, Dilesh Patel, Vadim V Fedorov, Emile G Daoud
BACKGROUND: Pacemakers (PM) are used for managing sick sinus syndrome (SSS). This study evaluates predictors and trends of PM implantation for SSS. METHODS: Patients were identified from the National Inpatient Sample dataset (2003-13). Included patients were ≥18 years old, had a diagnosis of sinus node dysfunction and atrial arrhythmia (i.e., SSS). Patients who died, transferred out, who had prior device or had a defibrillator or resynchronization therapy device implanted were excluded...
May 4, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28467647/prediction-of-optimal-cardiac-resynchronization-by-vectors-extracted-from-electrograms-in-dyssynchronous-canine-hearts
#7
Elien B Engels, Marc Strik, Lars B van Middendorp, Marion Kuiper, Kevin Vernooy, Frits W Prinzen
INTRODUCTION: Proper optimization of atrioventricular (AV) and interventricular (VV) intervals can improve the response to cardiac resynchronization therapy (CRT). It has been demonstrated that the area of the QRS complex (QRSarea) extracted from the vectorcardiogram can be used as a predictor of optimal CRT-device settings. We explored the possibility of extracting vectors from the electrograms (EGMs) obtained from pacing electrodes and of using these EGM-based vectors (EGMVs) to individually optimize acute haemodynamic CRT response...
May 3, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28398556/prognosis-associated-with-redo-cardiac-resynchronization-therapy-following-complete-device-and-lead-extraction-due-to-device-related-infection
#8
Martin Seifert, Viviane Moeller, Anita Arya, Thomas Schau, Frank Hoelschermann, Christian Butter
Aims: An increase in the number of cardiac resynchronization therapy (CRT) device implantations worldwide has led to a consequent increase in the number of infections associated with the device, making extraction of the CRT device inevitable. Redo CRT implantation after treatment and recovery following device extraction is challenging. This study aimed to evaluate the success rate, complications, and long-term prognosis of redo CRT implantation, including the rates of subclavian, cava, and coronary sinus (CS) vein thrombosis as well as re-infection...
April 6, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28387919/the-assessment-of-the-long-term-effects-of-elective-crt-d-of-coronary-heart-disease-after-pci
#9
K Liu, B-T Hua, T Guo, L-J Pu
OBJECTIVE: The present study was planned to evaluate the long-term effects of elective cardiac resynchronization therapy devices (CRT-D) of coronary heart disease after percutaneous coronary intervention (PCI). PATIENTS AND METHODS: We continuously selected 124 patients with chronic stable heart failure to undergo PCI, and were randomly divided into two groups viz. control group with 72 cases and observation group with 52 cases. The control group was given intensive drugs, while the observation group was treated with a combination of intensive drugs with CRT-D...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28363688/pharmacological-treatment-changes-of-chronic-heart-failure-during-cardiac-resynchronization-therapy-a-1-year-follow-up-study
#10
Diana Rinkuniene, Ausra Krivickiene, Jolanta Laukaitiene, Renaldas Jurkevicius
BACKGROUND: Cardiac resynchronization therapy (CRT) is associated with improved morbidity and mortality in patients with chronic heart failure (HF) on optimal medical therapy. We aimed to evaluate changes of medical therapy during CRT and its influence on the CRT response. METHODS: We evaluated 85 HF patients' pharmacological treatment changes during 1-year follow-up of CRT. Statistical analysis was performed using IBM SPSS statistical software (SPSS v.21.0 for Mac OS X)...
March 14, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28339581/rationale-and-design-of-the-budapest-crt-upgrade-study-a-prospective-randomized-multicentre-clinical-trial
#11
Bela Merkely, Annamaria Kosztin, Attila Roka, Laszlo Geller, Endre Zima, Attila Kovacs, Andras Mihaly Boros, Helmut Klein, Jerzy K Wranicz, Gerhard Hindricks, Marcell Clemens, Gabor Z Duray, Arthur J Moss, Ilan Goldenberg, Valentina Kutyifa
Aims: There is lack of conclusive evidence from randomized clinical trials on the efficacy and safety of upgrade to cardiac resynchronization therapy (CRT) in patients with implanted pacemakers (PM) or defibrillators (ICD) with reduced left ventricular ejection fraction (LVEF) and chronic heart failure (HF). The BUDAPEST-CRT Upgrade Study was designed to compare the efficacy and safety of CRT upgrade from conventional PM or ICD therapy in patients with intermittent or permanent right ventricular (RV) septal/apical pacing, reduced LVEF, and symptomatic HF...
October 6, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28316176/-association-of-serum-albumin-level-and-clinical-outcomes-among-heart-failure-patients-receiving-cardiac-resynchronization-therapy
#12
S W Yang, Z M Liu, J R Mi, S Y Liu, L G Ding, K P Chen, W Hua, S Zhang
Objective: To assess the relationship between serum albumin level and clinical outcome in heart failure (HF) patients receiving cardiac resynchronization therapy (CRT). Methods: In this retrospective cohort study, 357 consecutive chronic heart failure patients receiving CRT between January 2010 and December 2015 were enrolled and divided into two groups based on pre-CRT serum albumin (albumin≥40 g/L, n=244; albumin<40 g/L, n=113). Clinical outcomes were defined as all-cause mortality (including heart transplantation) and rehospitalization due to worsening HF...
March 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28315744/cardiac-implantable-electronic-device-infections-who-is-at-greatest-risk
#13
Parijat Saurav Joy, Gagan Kumar, Jeanne E Poole, Barry London, Brian Olshansky
BACKGROUND: Cardiac implantable electronic device (CIED) infections are associated with hospitalization, mortality, increased costs, and adverse outcomes. OBJECTIVE: Determine the burden of infections for CIEDs based on device type, associated comorbidities, and clinical characteristics over a 12-year period. METHODS: Utilizing data from the National Inpatient Sample database for cases from 2000 through 2012, we identified procedures for device-related infection (DRI) using International Statistical Classification of Diseases and Related Health Problems, Ninth Revision, Clinical Modification (ICD-9-CM) codes for CIED removal with diagnosis codes for device-related infection or systemic infection...
March 16, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28315562/improvement-in-left-ventricular-intrinsic-dyssynchrony-with-cardiac-resynchronization-therapy
#14
Serdar Bozyel, Ayşen Ağaçdiken Ağır, Tayfun Şahin, Umut Çelikyurt, Müjdat Aktaş, Onur Argan, İrem Yılmaz, Kurtuluş Karaüzüm, Emir Derviş, Ahmet Vural, Dilek Ural
OBJECTIVE: Cardiac resynchronization therapy (CRT) has been shown to induce a structural and electrical remodeling; the data on whether left ventricle (LV) reverse remodeling is associated with restitution of intrinsic contraction pattern are unknown. In this study, we investigated the presence of improvement in left ventricular intrinsic dyssynchrony in patients with CRT. METHODS: A total of 45 CRT recipients were prospectively studied. Dyssynchrony indexes including interventricular mechanical delay (IVMD) and tissue Doppler velocity opposing-wall delay (OWD) as well as QRS duration on 12-lead surface electrocardiogram were recorded before CRT device implantation...
March 3, 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28295869/predictors-of-short-term-clinical-response-to-cardiac-resynchronization-therapy
#15
Cecilia Linde, William T Abraham, Michael R Gold, J Claude Daubert, Anthony S L Tang, James B Young, Lou Sherfesee, J Harrison Hudnall, Dedra H Fagan, John G Cleland
AIMS: Cardiac resynchronization therapy (CRT) reduces morbidity and mortality in patients with symptomatic heart failure and QRS prolongation but there is uncertainty about which patient characteristics predict short-term clinical response. METHODS AND RESULTS: In an individual patient meta-analysis of three double-blind, randomized trials, clinical composite score (CCS) at 6 months was compared in patients assigned to CRT programmed on or off. Treatment-covariate interactions were assessed to measure likelihood of improved CCS at 6 months...
March 14, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28254128/a-multisensor-algorithm-predicts-heart%C3%A2-failure-events-in-patients-with-implanted-devices-results-from-the-multisense-study
#16
John P Boehmer, Ramesh Hariharan, Fausto G Devecchi, Andrew L Smith, Giulio Molon, Alessandro Capucci, Qi An, Viktoria Averina, Craig M Stolen, Pramodsingh H Thakur, Julie A Thompson, Ramesh Wariar, Yi Zhang, Jagmeet P Singh
OBJECTIVES: The aim of this study was to develop and validate a device-based diagnostic algorithm to predict heart failure (HF) events. BACKGROUND: HF involves costly hospitalizations with adverse impact on patient outcomes. The authors hypothesized that an algorithm combining a diverse set of implanted device-based sensors chosen to target HF pathophysiology could detect worsening HF. METHODS: The MultiSENSE (Multisensor Chronic Evaluation in Ambulatory Heart Failure Patients) study enrolled patients with investigational chronic ambulatory data collection via implanted cardiac resynchronization therapy defibrillators...
March 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28229200/-current-impact-of-cardiac-implantable-electronic-devices
#17
J Kuschyk, B Rudic, M Borggrefe, I Akin
Sudden cardiac death and chronic heart failure are among the main contributors to persisting high mortality rates in Germany. In addition to removal of causal factors and guideline-conform pharmacological therapy, therapy with cardiac implantable electronic devices (CIED) is of undisputed importance. Subcutaneous defibrillators have the advantage that they do not have intracardiac electrodes but still have the same efficacy and safety. For patients with a wide QRS complex and reduced ejection fraction, cardiac resynchronization has led to a reduction of morbidity and mortality...
February 22, 2017: Herz
https://www.readbyqxmd.com/read/28225475/stretching-exercises-improve-vascular-endothelial-dysfunction-through-attenuation-of-oxidative-stress-in-chronic-heart-failure-patients-with-an-implantable-cardioverter-defibrillator
#18
Michitaka Kato, Takashi Masuda, Michio Ogano, Kazuki Hotta, Hisato Takagi, Shinya Tanaka, Yumi Kamada, Ayako Akiyama, Daisuke Kamekawa, Ryosuke Shimizu, Minoru Tabata, Jun Tanabe, Takuya Umemoto
PURPOSE: Endurance training improves oxidative stress and vascular endothelial dysfunction in patients with chronic heart failure (CHF). However, patients with CHF and an implantable cardioverter defibrillator (ICD) or cardiac resynchronization therapy-defibrillator (CRT-D) often avoid endurance training for fear of ICD shock. Recent studies have reported that stretching exercises enhance antioxidant activity and improve vascular responses. Therefore, we aimed to assess the effects of 4 weeks of stretching exercises on oxidative stress and vascular endothelial function in patients with CHF with an ICD or CRT-D...
March 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/28214846/circulating-mir-30d-predicts-survival-in-patients-with-acute-heart-failure
#19
Junjie Xiao, Rongrong Gao, Yihua Bei, Qiulian Zhou, Yanli Zhou, Haifeng Zhang, Mengchao Jin, Siqi Wei, Kai Wang, Xuejuan Xu, Wenming Yao, Dongjie Xu, Fang Zhou, Jingfa Jiang, Xinli Li, Saumya Das
BACKGROUND/AIMS: Identification of novel biomarkers to identify acute heart failure (AHF) patients at high risk of mortality is an area of unmet clinical need. Recently, we reported that the baseline level of circulating miR-30d was associated with left ventricular remodeling in response to cardiac resynchronization therapy in advanced chronic heart failure patients. However, the role of circulating miR-30d as a prognostic marker of survival in patients with AHF has not been explored...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28202628/effects-of-upgrade-versus-de-novo-cardiac-resynchronization-therapy-on-clinical-response-and-long-term-survival-results-from-a-multicenter-study
#20
MULTICENTER STUDY
Mate Vamos, Julia W Erath, Zsolt Bari, Denes Vagany, Sven P Linzbach, Tatsiana Burmistrava, Carsten W Israel, Gabor Z Duray, Stefan H Hohnloser
BACKGROUND: Benefits of cardiac resynchronization therapy (CRT) on morbidity and mortality in selected patients are well known. Although the number of upgrade procedures from single- or dual-chamber devices to CRT is increasing, there are only sparse data on the outcomes of upgrade procedures compared with de novo CRT. This study aimed to evaluate clinical response and survival in patients receiving de novo versus upgrade CRT defibrillator therapy. METHODS AND RESULTS: Prospectively collected outcome data were compared in patients undergoing de novo or upgrade CRT defibrillator implantation at 3 implant centers in Germany and Hungary...
February 2017: Circulation. Arrhythmia and Electrophysiology
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