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Chronic Resynchronization Therapy

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https://www.readbyqxmd.com/read/29435789/chronic-right-ventricular-pacing-in-the-heart-failure-population
#1
REVIEW
Justin Gould, Benjamin Sieniewicz, Bradley Porter, Baldeep Sidhu, Christopher A Rinaldi
PURPOSE OF REVIEW: We review the trials that have demonstrated potentially harmful effects from right ventricular (RV) apical pacing as well as reviewing the evidence of alternative RV pacing sites and cardiac resynchronization therapy (CRT) for patients who have heart failure and atrioventricular (AV) block. RECENT FINDINGS: The role of CRT in patients with AV block and impaired left ventricular function remains an important consideration. The BLOCK HF trial demonstrated better outcomes with CRT pacing over RV pacing in patients with left ventricular systolic dysfunction (LVSD) and AV block who were expected to have a high RV pacing burden, but failed to demonstrate a mortality benefit...
February 12, 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29425552/sex-related-differences-in-chronic-heart-failure
#2
Alberto Aimo, Giuseppe Vergaro, Andrea Barison, Silvia Maffei, Chiara Borrelli, Doralisa Morrone, Matteo Cameli, Alberto Palazzuoli, Giuseppe Ambrosio, Stefano Coiro, Ketty Savino, Elisabetta Cerbai, Rossella Marcucci, Roberto Pedrinelli, Luigi Padeletti, Claudio Passino, Michele Emdin
The prevalence of chronic heart failure (CHF) is steadily increasing. Both sexes are affected, with significant differences in etiology, epidemiology and clinical presentation, prognosis, comorbidities, and response to treatment. Women tend to develop CHF at a more advanced age, present more often with HF with preserved ejection fraction, are more symptomatic, and have a worse quality of life than men, but also a better prognosis. In women, CHF has more frequently a non-ischemic etiology, and arterial hypertension and diabetes mellitus are leading comorbidities...
March 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29424196/exercise-based-cardiac-rehabilitation-in-cardiac-resynchronization-therapy-recipients-a-primer-for-practicing-clinicians
#3
Marco Ambrosetti, Simona Sarzi Braga, Franco Giada, Roberto F E Pedretti
Cardiac resynchronization therapy (CRT) is a therapeutic option of increasing importance for chronic heart failure (CHF) and criteria for implantation now concern a large amount of patient populations. As a consequence, subjects with ongoing CRT (or immediately after CRT implantation) are more often referred to Cardiac Rehabilitation (CR) programmes, and it has been recently estimated that about one third of CHF patients attending CR in Italy currently have this kind of device. The presence of CRT represents a modulating factor for exercise prescription and monitoring, since CRT patients may be considered per se as a target group for CR...
November 30, 2017: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/29342243/devices-in-heart-failure-diagnosis-detection-and-disease-modification
#4
John Gierula, Mark T Kearney, Klaus K Witte
Introduction/background: Implantable cardiac devices are widely used in chronic heart failure (CHF) therapy. This review covers current CHF treatment with electronic cardiac devices, areas of discussion and emerging technologies. Sources of data: A comprehensive search of available literature resources including Pubmed, MEDLINE and EMBASE was performed. National and international guidelines were accessed. Areas of agreement: Excessive right ventricular pacing is detrimental to cardiac function...
January 12, 2018: British Medical Bulletin
https://www.readbyqxmd.com/read/29313369/characteristics-and-prognosis-of-heart-failure-with-improved-compared-with-persistently-reduced-ejection-fraction-a-systematic-review-and-meta-analyses
#5
Mads E Jørgensen, Charlotte Andersson, Ramachandran S Vasan, Lars Køber, Jawdat Abdulla
Aims We assessed the clinical characteristics and prognosis of chronic heart failure patients with improved ejection fraction (HFIEF) compared with persistently reduced ejection fraction (HFpREF) after evidence-based therapy. Methods and results We performed a meta-analysis including 24 eligible observational studies comparing 2663 HFIEF (≥5% left ventricular ejection fraction (LVEF) improvement) versus 8355 HFpREF patients who received recommended drug therapy, cardiac resynchronization therapy and/or intracardiac defibrillator...
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29308851/redo-procedures-and-chronic-renal-dysfunction-are-associated-with-higher-risk-of-cardiac-electronic-device-infections
#6
Giovanni Morani, Giacomo Mugnai, Bruna Bolzan, Martina Morosato, Luca Tomasi, Sara Ferrari, Corrado Vassanelli
BACKGROUND: Infection is a major complication of pacemaker (PM) and implantable cardioverter-defibrillator (ICD) implantation. The present study sought to analyse the incidence rate of device infections, to investigate possible relationships between first implantations/repeated procedures and infection rates, and to identify some main risk factors associated with infection of cardiac implantable electronic devices (CIED). METHODS: In a single center retrospective observational study, records of 3899 consecutive patients having undergone PM and ICD implantation, cardiac resynchronization therapy (CRT) or revision (device/lead replacements or upgrades) and between 2002 and 2012 were obtained...
January 5, 2018: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29297189/are-changes-in-heart-rate-observed-during-dobutamine-stress-echocardiography-associated-with-a-response-to-cardiac-resynchronization-therapy-in-patients-with-severe-heart-failure-results-of-a-multicenter-viacrt-study
#7
Wojciech Gilewski, Jan Błażejewski, Danuta Karasek, Joanna Banach, Łukasz Wołowiec, Edyta Płońska-Gościniak, Tomasz Kukulski, Jarosław Kasprzak, Katarzyna Mizia-Stec, Ilona Kowalik, Piotr Gościniak, Władysław Sinkiewicz
BACKGROUND: According to current ESC Guidelines for the diagnosis and treatment of heart failure cardiac resynchronization therapy (CRT) is indicated in patients suffering from heart failure (HF) with reduced ejection fraction (EF) with significantly widened QRS complexes. Presence of vital myocardium proved by dobutamine stress echocardiography (DSE) is considered as a good prognostic factor for responsiveness to this treatment. Chronotropic incompetence is on the other hand known factor of unfavorable outcome in HF...
January 3, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29286395/benefits-of-cardiac-resynchronization-therapy-in-an-asynchronous-heart-failure-model-induced-by-left-bundle-branch-ablation-and-rapid-pacing
#8
Jingfeng Wang, Zhenning Nie, Haiyan Chen, Xianhong Shu, Zhaohua Yang, Ruiming Yao, Yangang Su, Junbo Ge
It is now well recognized that heart failure (HF) patients with left bundle branch block (LBBB) derive substantial clinical benefits from cardiac resynchronization therapy (CRT), and LBBB has become one of the important predictors for CRT response. The conventional tachypacing-induced HF model has several major limitations, including absence of stable LBBB and rapid reversal of left ventricular (LV) dysfunction after cessation of pacing. Hence, it is essential to establish an optimal model of chronic HF with isolated LBBB for studying CRT benefits...
December 11, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29185615/predictors-of-total-mortality-and-echocardiographic-response-for-cardiac-resynchronization-therapy-a-cohort-study
#9
Guilherme Ferreira Gazzoni, Matheus Bom Fraga, Andres Di Leoni Ferrari, Pablo da Costa Soliz, Anibal Pires Borges, Eduardo Bartholomay, Carlos Antonio Abunader Kalil, Vanessa Giaretta, Luis Eduardo Paim Rohde
BACKGROUND: Clinical studies demonstrate that up to 40% of patients do not respond to cardiac resynchronization therapy (CRT), thus, appropriate patient selection is critical to the success of CRT in heart failure. OBJECTIVE: Evaluation of mortality predictors and response to CRT in the Brazilian scenario. METHODS: Retrospective cohort study including patients submitted to CRT in a tertiary hospital in southern Brazil from 2008 to 2014. Survival was assessed through a database of the State Department of Health (RS)...
November 27, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29081396/beneficial-effects-of-upgrading-to-his-bundle-pacing-in-chronically-paced-patients-with-left-ventricular-ejection-fraction-50
#10
Peiren Shan, Lan Su, Xiaodong Zhou, Shengjie Wu, Lei Xu, Fangyi Xiao, Xiaohong Zhou, Kenneth A Ellenbogen, Weijian Huang
BACKGROUND: Heart failure is common in patients with permanent pacemakers. Right ventricular (RV) pacing may worsen cardiac function, while the nonresponder rate of cardiac resynchronization therapy (CRT) for heart failure treatment remains 25%-30%. OBJECTIVE: The purpose of this study was to assess clinical outcomes of upgrading to permanent His bundle pacing (pHBP) in patients with heart failure who underwent device upgrade from right ventricular pacing or CRT nonresponse...
November 16, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29054593/association-between-the-baseline-peripheral-blood-monocyte-counts-the-size-of-spleen-and-the-response-to-cardiac-resynchronization-therapy
#11
Mami Fujinami, Hidekazu Kondo, Kunio Yufu, Tetsuji Shinohara, Yumi Ishii, Yasushi Teshima, Mikiko Nakagawa, Naohiko Takahashi
BACKGROUND: Spleen reserves monocytes, which deploy to inflammatory sites. Monocytosis is known to be observed in chronic low-grade inflammatory state, including chronic heart failure (CHF). CHF also induces splenomegaly. We tested the hypotheses that the number of peripheral blood monocytes and size of spleen at baseline could be related to the response to cardiac resynchronization therapy (CRT). METHODS: From 2010, a total of 49 consecutive patients implanted with CRT device were evaluated at baseline and 6-8 months later...
October 17, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/29045311/cardiac-resynchronization-therapy-outcomes-in-patients-with-chronic-heart-failure-cardiac-resynchronization-therapy-with-pacemaker-versus-cardiac-resynchronization-therapy-with-defibrillator
#12
Michael Drozd, John Gierula, Judith E Lowry, Maria F Paton, Eleanor Joy, Haqeel A Jamil, Richard M Cubbon, Mark T Kearney, David A Cairns, Klaus K Witte
AIMS: Cardiac resynchronization therapy (CRT) for chronic heart failure with left ventricular systolic dysfunction (LVSD) consistently improves survival against optimal medical therapy alone. Limited data exist comparing the outcomes between CRT with pacemaker (CRT-P) and with defibrillator (CRT-D). We aimed to investigate the long-term prognosis of patients who received CRT-P or CRT-D. METHODS AND RESULTS: Data were prospectively collected from consecutive patients with standard indications for CRT, who were implanted at a single large tertiary centre between 2008 and 2012...
December 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29021843/impact-of-baseline-renal-function-on-all-cause-mortality-in-patients-who-underwent-cardiac-resynchronization-therapy-a-systematic-review-and-meta-analysis
#13
REVIEW
G Bazoukis, K P Letsas, P Korantzopoulos, C Thomopoulos, K Vlachos, S Georgopoulos, N Karamichalakis, A Saplaouras, M Efremidis, A Sideris
BACKGROUND: Cardiac resynchronization therapy (CRT) improves both morbidity and mortality in selected patients with heart failure and increased QRS duration. However, chronic kidney disease (CKD) may have an adverse effect on patient outcome. The aim of this systematic review was to analyze the existing data regarding the impact of baseline renal function on all-cause mortality in patients who underwent CRT. METHODS: Medline database was searched systematically, and studies evaluating the effect of baseline renal function on all-cause mortality in patients who underwent CRT were retrieved...
October 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/28932489/the-impact-of-cardiac-resynchronization-therapy-on-routine-laboratory-parameters
#14
András Mihály Boros, Péter Perge, Klaudia Vivien Nagy, Astrid Apor, Zsolt Bagyura, Endre Zima, Levente Molnár, Tamás Tahin, Dávid Becker, László Gellér, Béla Merkely, Gábor Széplaki
BACKGROUND: Cardiac resynchronization therapy (CRT) in chronic heart failure has been shown to improve mortality and morbidity. However, comprehensive data are not available as concerns how circulating biomarkers reflecting different organ functions, such as serum uric acid, blood urea nitrogen (BUN), albumin, cholesterol, or various liver enzymes, change over time as a consequence of CRT. The aim of this prospective study was to overview these possible changes. METHODS: A total of 20 routine laboratory parameters were measured in 122 control subjects and in 129 patients with chronic heart failure before CRT, 6 months, and 2 years later...
March 2017: Interventional Medicine & Applied Science
https://www.readbyqxmd.com/read/28883848/interleukin-6-signaling-in-patients-with-chronic-heart-failure-treated-with-cardiac-resynchronization-therapy
#15
Katarzyna Ptaszynska-Kopczynska, Anna Szpakowicz, Marta Marcinkiewicz-Siemion, Anna Lisowska, Ewa Waszkiewicz, Marcin Witkowski, Piotr Jakim, Bogdan Galar, Wlodzimierz J Musial, Karol A Kamiński
INTRODUCTION: Increased expression of interleukin-6 (IL-6) has been described in left ventricular dysfunction in the course of chronic heart failure. Cardiac resynchronization therapy (CRT) is a unique treatment method that may reverse the course of chronic heart failure (CHF) with reduced ejection fraction (HF-REF). We aimed to evaluate the IL-6 system, including soluble IL-6 receptor (sIL-6R) and soluble glycoprotein 130 (sgp130), in HF-REF patients, with particular emphasis on CRT effects...
August 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28879633/the-initial-evaluation-and-management-of-a-patient-with-heart-failure
#16
REVIEW
Jamael Hoosain, Jabar Whittier, Farhan Hasni, Shelley Hankins
PURPOSE OF REVIEW: The goal of this review is to summarize and discuss a thorough and effective manner in the evaluation of the patient with heart failure. RECENT FINDINGS: Heart failure is a prevalent disease worldwide and while the diagnosis of heart failure has remained relatively unchanged via a careful history and physical examination, identification of the etiology of the heart failure and treatment has made significant advances. Mechanical circulatory support (MCS), neprilysin inhibitors, and chronic resynchronization therapy (CRT) are just some of the relatively recent therapies afforded to assist heart failure patients...
September 6, 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28871373/-acute-and-chronic-heart-failure
#17
K-P Kresoja, G Schmidt, B Kherad, F Krackhardt, F Spillmann, C Tschöpe
The initial therapy of chronic heart failure is still based on diuretics, angiotensin-converting enzyme (ACE) inhibitors, beta-blockers and in specific cases mineralocorticoid receptor antagonists. The new European Society of Cardiology (ESC) guidelines published in 2016 introduced angiotensin-receptor-neprilysin inhibitors, such as sacubitril/valsartan (LCZ 696) as new therapeutic agents in patients with chronic and progressive heart failure. New subgroup analyses for LCZ 696 have been published showing a beneficial effect in the context of various comorbidities, such as renal insufficiency, diabetes and hypotension...
November 2017: Herz
https://www.readbyqxmd.com/read/28853057/erratum-to-updates-in-cardiac-resynchronization-therapy-for-chronic-heart-failure-review-of-multisite-pacing
#18
Antonios P Antoniadis, Ben Sieniewicz, Justin Gould, Bradley Porter, Jessica Webb, Simon Claridge, Jonathan M Behar, Christopher Aldo Rinaldi
No abstract text is available yet for this article.
October 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28814710/left-univentricular-pacing-by-rate-adaptive-atrioventricular-delay-in-treatment-of-chronic-heart-failure
#19
Lulu Zhao, Ling Zhao, Lijin Pu, Baotong Hua, Yu Wang, Shumin Li, Qing Li, Tao Guo
BACKGROUND Cardiac resynchronization therapy (CRT) is efficacious in the treatment of chronic heart failure (CHF); however, because it is non-physiological, some patients are unresponsive. The present study used rate-adaptive atrioventricular delay (RAAVD) to track the physiological atrioventricular delay and investigated the effects of left univentricular pacing on CRT. MATERIAL AND METHODS Patients with CHF fulfilling the indication of CRT Class I were categorized into a left univentricular pacing by RAAVD group and a standard biventricular pacing group...
August 17, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28757175/-main-novelties-of-the-last-set-of-european-guidelines-for-the-management-of-heart-failure
#20
Richard Isnard, Nadjib Hammoudi, Lise Legrand, Françoise Pousset
Heart failure is the main chronic disease in cardiology. Its prognosis remains poor despite improvements in its management that allow patients to live increasingly longer with this disease, alternating periods of stability and episodes of decompensation. Treatment guidelines are regularly updated to integrate new results of recent trials that are likely to influence routine care. These guidelines are proposed with different classes of recommendations and difference levels of evidence. It is of paramount importance to summarize the guidelines to make them accessible to the vast majority of cardiologists and easier to read to promote their application...
July 2017: La Presse Médicale
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