keyword
https://read.qxmd.com/read/38493496/chromatin-modifier-ep400-regulates-oocyte-quality-and-zygotic-genome-activation-in-mice
#1
JOURNAL ARTICLE
Qing Tian, Ying Yin, Yu Tian, Yufan Wang, Yong-Feng Wang, Rikiro Fukunaga, Toshihiro Fujii, Ai-Hua Liao, Lei Li, Wei Zhang, Ximiao He, Wenpei Xiang, Li-Quan Zhou
Epigenetic modifiers that accumulate in oocytes, play a crucial role in steering the developmental program of cleavage embryos and initiating life. However, the identification of key maternal epigenetic regulators remains elusive. In the findings, the essential role of maternal Ep400, a chaperone for H3.3, in oocyte quality and early embryo development in mice is highlighted. Depletion of Ep400 in oocytes resulted in a decline in oocyte quality and abnormalities in fertilization. Preimplantation embryos lacking maternal Ep400 exhibited reduced major zygotic genome activation (ZGA) and experienced developmental arrest at the 2-to-4-cell stage...
March 17, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38483019/learning-stiffness-tensors-in-self-activated-solids-via-a-local-rule
#2
JOURNAL ARTICLE
Yuxuan Tang, Wenjing Ye, Jingjing Jia, Yangyang Chen
Mechanical metamaterials are often designed with particular properties for specific load-bearing functions. Alternatively, this study aims to create a class of active lattice metamaterials, dubbed self-activated solids, that can learn desired stiffness tensors from the elastic deformations they experienced, a crucial feature to improve the performance, efficiency, and functionality of materials. Artificial adaptive matters that combine sensory, control, and actuation elements can offer appealing solutions. However, challenges still remain: The designs will rely on accurate off-line and global computations, as well as intricate coordination among individual elements...
March 14, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38218054/a-latent-class-analysis-of-adolescent-dating-violence-associations-with-daily-conflict-management
#3
JOURNAL ARTICLE
Alison Paradis, Andréanne Fortin, Tinneke Van Camp, Martine Hébert, Mylène Fernet
BACKGROUND: Adolescent dating violence (ADV) is a major public health concern experienced by more than half of adolescents. Previous studies have found considerable diversity in patterns of ADV and suggest that its various forms often occur concurrently and reciprocally within adolescent dating relationships. While multiple robust distal correlates of ADV have already been established, research on situational factors, such as conflict-related variables, is still sparse. OBJECTIVE: This study aimed to identify patterns of ADV based on the co-occurrence of different types of ADV victimization and perpetration...
January 12, 2024: Child Abuse & Neglect
https://read.qxmd.com/read/37919789/analysis-of-respiratory-virus-detection-in-hospitalized-children-with-acute-respiratory-infection-during-the-covid-19-pandemic
#4
JOURNAL ARTICLE
Ruoya Wu, Jianwei Zhang, Liyan Mo
OBJECTIVE: It is now understood that the Coronavirus disease 2019 (COVID-19) pandemic and its associated containment measures have influenced the epidemiology of other respiratory viruses. This study aimed to characterize respiratory virus infections in pediatric patients hospitalized for acute respiratory infections (ARIs) in East China both prior to and during the COVID-19 pandemic. METHODS: We collected nasal secretions from 9782 pediatric ARI patients admitted to Shaoxing Maternal and Child Health Care Hospital between January 2018 and December 2022...
November 2, 2023: Virology Journal
https://read.qxmd.com/read/37226475/longitudinal-associations-between-adolescent-dating-violence-victimization-and-adverse-outcomes-a-systematic-review
#5
REVIEW
Laura Campo-Tena, Simon R Larmour, Noemí Pereda, Manuel P Eisner
Evidence on the outcomes of adolescent dating violence (ADV) victimization mainly derives from cross-sectional studies, which have limitations in suggesting causal relationships. Furthermore, the complexity of factors and overlapping dimensions in dating violence research, such as the forms of violence experienced, may have contributed to the variability of findings across the literature. To address these gaps and provide a more comprehensive understanding of the impact of ADV, this study reviews findings from prospective cohort studies, with a focus on the type of violence experienced and the gender of the victim...
May 25, 2023: Trauma, Violence & Abuse
https://read.qxmd.com/read/37072673/systemic-tumor-suppression-via-macrophage-driven-automated-homing-of-metal-phenolic-gated-nanosponges-for-metastatic-melanoma
#6
JOURNAL ARTICLE
Xue Liao, Guidong Gong, Mengyuan Dai, Zhenyu Xiang, Jiezhou Pan, Xianglian He, Jiaojiao Shang, Anna Maria Blocki, Zongmin Zhao, C Wyatt Shields, Junling Guo
Cell-based therapies comprising the administration of living cells to patients for direct therapeutic activities have experienced remarkable success in the clinic, of which macrophages hold great potential for targeted drug delivery due to their inherent chemotactic mobility and homing ability to tumors with high efficiency. However, such targeted delivery of drugs through cellular systems remains a significant challenge due to the complexity of balancing high drug-loading with high accumulations in solid tumors...
April 18, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/36776569/dating-violence-prevalence-and-risk-factors-among-adolescents-14-19-years-in-urban-public-schools-in-panama
#7
JOURNAL ARTICLE
Amanda Gabster, Casey D Xavier Hall, Anyi Yu Pon, Eugenia Millender, Frank Frankie Y Wong, Juan Miguel Pascale
BACKGROUND: Adolescent dating violence (ADV) can have lasting effects on youth's well-being and development. However, few studies in Latin America have described its prevalence and risk factors for having experienced ADV. METHODS: We conducted a multisite, cross-sectional study using two-stage cluster sampling among adolescents (14-19 years) attending public high schools in the urban districts of Panama, San Miguelito, Colón, and Arraiján/La Chorrera from 2015 to 2018 (N = 2469)...
January 2023: Lancet Reg Health Am
https://read.qxmd.com/read/36382738/the-moderating-influence-of-school-adult-connectedness-on-adolescent-dating-violence-and-mental-health
#8
JOURNAL ARTICLE
Pooja Brar, Maura Shramko, Sarah Taylor, Marla Eisenberg
BACKGROUND: Adolescent dating violence (ADV) continues to be a health concern. Most previous research has examined physical and or sexual ADV with little attention to verbal violence. METHODS: Drawing on the social-ecological framework, the current study examined the moderating influence of school adult connectedness on experiences of verbal only, physical and/or sexual violence (combination ADV), and mental health outcomes among 11th graders (n = 31,459) in one Midwestern state...
November 16, 2022: Journal of School Health
https://read.qxmd.com/read/36351249/benefits-of-an-immunogenic-personalized-neoantigen-nanovaccine-in-patients-with-high-risk-gastric-gastroesophageal-junction-cancer
#9
JOURNAL ARTICLE
Qin Liu, Yanhong Chu, Jie Shao, Hanqing Qian, Ju Yang, Huizi Sha, Lanqi Cen, Manman Tian, Qiuping Xu, Fangjun Chen, Yang Yang, Weifeng Wang, Kai Wang, Lixia Yu, Jia Wei, Baorui Liu
Personalized neoantigen vaccines have shown strong immunogenicity in clinical trial, but still face various challenges in facilitating an efficient antitumor immune response. Here, a personalized neoantigen nanovaccine (PNVAC) platform for adjuvant cancer immunotherapy is generated. PNVAC triggers superior protective efficacy against tumor recurrence and promotes longer survival than free neoantigens, especially when combined with anti-PD-1 treatment in a murine tumor model. A phase I clinical trial (ChiCTR1800017319) is initiated to evaluate the safety, immunogenicity, and prophylactic effect of PNVAC on preventing tumor recurrence in patients with high-risk gastric/gastroesophageal junction cancer after adjuvant chemotherapy of postsurgical resection...
November 9, 2022: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/36031406/extracellular-hydraulic-resistance-enhances-cell-migration
#10
JOURNAL ARTICLE
Debonil Maity, Kaustav Bera, Yizeng Li, Zhuoxu Ge, Qin Ni, Konstantinos Konstantopoulos, Sean X Sun
Cells migrating in vivo encounter microenvironments with varying physical properties. One such physical variable is the fluid viscosity surrounding the cell. Increased viscosity is expected to increase the hydraulic resistance experienced by the cell and decrease cell speed. The authors demonstrate that contrary to this expected result, cells migrate faster in high viscosity media on 2-dimensional substrates. Both actin dynamics and water dynamics driven by ion channel activity are examined. Results show that cells increase in area in high viscosity and actomyosin dynamics remain similar...
August 28, 2022: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/35973811/adolescent-experience-with-dating-violence-in-relation-to-virginity-status-findings-from-a-jamaican-sample
#11
EDITORIAL
Gillian E Mason
The association between adolescents' involvement in sexual intercourse and their experiences with adolescent dating violence (ADV) is an understudied topic. This study examined this relationship for 178 Jamaican adolescents in Grades 9-11. The expectation that adolescents who reported having had sexual intercourse would report greater victimization and greater perpetration than adolescents who had not had intercourse was consistent only for sexual abuse. Analyses also showed that sexually experienced males perpetrated and experienced more psychological abuse compared to males who were not so experienced...
August 16, 2022: Violence and Victims
https://read.qxmd.com/read/35930332/web-based-delivery-of-a-family-based-dating-violence-prevention-program-for-youth-who-have-been-exposed-to-intimate-partner-violence-protocol-for-an-acceptability-and-feasibility-study
#12
JOURNAL ARTICLE
H Luz McNaughton Reyes, Eliana Gabriela Armora Langoni, Laurel Sharpless, Natalie Blackburn, Agnieszka McCort, Rebecca J Macy, Kathryn E Moracco, Vangie A Foshee
BACKGROUND: Children exposed to intimate partner violence (IPV) between caregivers are at an increased risk of becoming involved in dating violence during adolescence. However, to date, few adolescent dating violence (ADV) prevention programs have been developed for and evaluated with youth exposed to IPV. An exception is Moms and Teens for Safe Dates (MTSD), an evidence-based ADV prevention program for mothers or maternal caregivers (mothers) exposed to IPV and their teenagers. The MTSD program comprises a series of booklets that families complete together in a home that includes activities to promote positive family communication and healthy teenager relationships...
August 5, 2022: JMIR Research Protocols
https://read.qxmd.com/read/35694002/a-systematic-review-of-secondary-traumatic-stress-and-compassion-fatigue-in-teachers
#13
REVIEW
Heather E Ormiston, Malena A Nygaard, Sophia Apgar
When teachers care for children with trauma histories, they are at risk of developing compassion fatigue (CF), or a reduced empathic capacity (Hupe and Stevenson in J Child Custody Res Issues Pract 16(4):364-386, 2019. https://doi.org/10.1080/15379418.2019.1663334). They may also develop secondary traumatic stress (STS), a secondary condition resulting from a person learning about details of a traumatic event experienced by someone in their care (Essary et al. in Kappa Delta Pi Record 56(3):116-121, 2020). While CF and STS have been studied widely in healthcare and mental health professionals (Baird and Kracen in Couns Psychol Q 19(2):181-188, 2006; Caringi et al...
2022: School Mental Health
https://read.qxmd.com/read/35508805/cyclic-mechanical-stresses-alter-erythrocyte-membrane-composition-and-microstructure-and-trigger-macrophage-phagocytosis
#14
JOURNAL ARTICLE
Antoni Garcia-Herreros, Yi-Ting Yeh, Zhangli Peng, Juan C Del Álamo
Red blood cells (RBCs) are cleared from the circulation when they become damaged or display aging signals targeted by macrophages. This process occurs mainly in the spleen, where blood flows through submicrometric constrictions called inter-endothelial slits (IES), subjecting RBCs to large-amplitude deformations. In this work, RBCs are circulated through microfluidic devices containing microchannels that replicate the IES. The cyclic mechanical stresses experienced by the cells affect their biophysical properties and molecular composition, accelerating cell aging...
July 2022: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/35311565/mycoplasma-pneumoniae-and-adenovirus-coinfection-cause-pediatric-severe-community-acquired-pneumonia
#15
JOURNAL ARTICLE
Fei Li, Yuhan Zhang, Peng Shi, Linfeng Cao, Liyun Su, Pan Fu, Kuerbanjiang Abuduxikuer, Libo Wang, Yin Wang, Roujian Lu, Wenjie Tan, Jun Shen
Consolidation is one complication of pediatric severe community-acquired pneumonia (SCAP) that can respond poorly to conservative medical treatment. We investigated the pathogens that cause pediatric SCAP including cases with persistent consolidation that need bronchoscopy intervention. Alveolar lavage fluid (ALF) samples collected from cases admitted to Children's Hospital of Fudan University with SCAP during January 2019 to March in 2019 were retrospectively tested by the RespiFinder 2SMART multiplex PCR (multi-PCR) assay targeting 22 respiratory pathogens...
April 27, 2022: Microbiology Spectrum
https://read.qxmd.com/read/34923777/biophysical-approaches-for-applying-and-measuring-biological-forces
#16
REVIEW
Wenxu Sun, Xiang Gao, Hai Lei, Wei Wang, Yi Cao
Over the past decades, increasing evidence has indicated that mechanical loads can regulate the morphogenesis, proliferation, migration, and apoptosis of living cells. Investigations of how cells sense mechanical stimuli or the mechanotransduction mechanism is an active field of biomaterials and biophysics. Gaining a further understanding of mechanical regulation and depicting the mechanotransduction network inside cells require advanced experimental techniques and new theories. In this review, the fundamental principles of various experimental approaches that have been developed to characterize various types and magnitudes of forces experienced at the cellular and subcellular levels are summarized...
February 2022: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/34738774/a-snapshot-global-survey-on-side-effects-of-covid-19-vaccines-among-healthcare-professionals-and-armed-forces-with-a-focus-on-headache
#17
COMPARATIVE STUDY
Armando Perrotta, Giuseppe Biondi-Zoccai, Wael Saade, Fabio Miraldi, Andrea Morelli, Antonino G Marullo, Elena Cavarretta, Roberto Carnevale, Elena DE Falco, Isotta Chimenti, Sebastiano Sciarretta, Paola Frati, Mamas A Mamas, Sara Ciardi, Luigi Frati, Giacomo Frati, Mariangela Peruzzi
BACKGROUND: New messenger RNA (mRNA) and adenovirus-based vaccines (AdV) against Coronavirus disease 2019 (COVID-19) have entered large scale clinical trials. Since healthcare professionals (HCPs) and armed forces personnel (AFP) represent a high-risk category, they act as a suitable target population to investigate vaccine-related side effects, including headache, which has emerged as a common complaint. METHODS: We investigated the side-effects of COVID-19 vaccines among HCPs and AFP through a 38 closed-question international survey...
September 2021: Panminerva Medica
https://read.qxmd.com/read/34559474/clinical-features-of-chinese-children-with-covid-19-and-other-viral-respiratory-infections
#18
JOURNAL ARTICLE
Zhen-Zhen Zhang, Da-Peng Chen, Quan-Bo Liu, Chuan Gan, Li Jiang, Kun Zhu, Xia-Yi Zhang, Hong-Mei Xu, Ai-Long Huang, Quan-Xin Long, Hai-Jun Deng, Juan Chen
OBJECTIVE: Few studies have explored the clinical features in children infected with SARS-CoV-2 and other common respiratory viruses, including respiratory syncytial virus (RSV), Influenza virus (IV), and adenovirus (ADV). Herein, we reported the clinical characteristics and cytokine profiling in children with COVID-19 or other acute respiratory tract infections (ARTI). METHODS: We enrolled 20 hospitalized children confirmed as COVID-19 positive, 58 patients with ARTI, and 20 age and sex-matched healthy children...
January 2022: Pediatric Pulmonology
https://read.qxmd.com/read/33854875/tactile-avatar-tactile-sensing-system-mimicking-human-tactile-cognition
#19
JOURNAL ARTICLE
Kyungsoo Kim, Minkyung Sim, Sung-Ho Lim, Dongsu Kim, Doyoung Lee, Kwonsik Shin, Cheil Moon, Ji-Woong Choi, Jae Eun Jang
As a surrogate for human tactile cognition, an artificial tactile perception and cognition system are proposed to produce smooth/soft and rough tactile sensations by its user's tactile feeling; and named this system as "tactile avatar". A piezoelectric tactile sensor is developed to record dynamically various physical information such as pressure, temperature, hardness, sliding velocity, and surface topography. For artificial tactile cognition, the tactile feeling of humans to various tactile materials ranging from smooth/soft to rough are assessed and found variation among participants...
April 2021: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/33762133/the-national-prevalence-of-adolescent-dating-violence-in-canada
#20
JOURNAL ARTICLE
Deinera Exner-Cortens, Elizabeth Baker, Wendy Craig
PURPOSE: The national prevalence of adolescent dating violence (ADV) in Canada is currently unknown. This study presents the first nationally representative Canadian data on prevalence and correlates of ADV victimization and perpetration. METHODS: This study analyzed data from the 2017/2018 Health-Behavior in School-Aged Children (HBSC) dataset. Youth from all 10 provinces and two territories participated. The analysis sample includes 3,711 participants (mean age = 15...
March 21, 2021: Journal of Adolescent Health
keyword
keyword
3093
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.