keyword
https://read.qxmd.com/read/38371379/galectin-3-promotes-fibrosis-in-ovarian-endometriosis
#21
JOURNAL ARTICLE
Guimin Yang, Yupeng Deng, Guangming Cao, Chongdong Liu
OBJECTIVE: This study aimed to investigate the potential role of galectin-3 (Gal-3) in the pathogenesis of fibrotic alterations in ovarian endometriosis (OVE). METHODS: In this study, we collected the ectopic endometrial tissues and eutopic endometrial tissues from 31 OVE patients treated by laparoscopy, and the eutopic endometrial tissues from 23 non-OVE patients with leiomyoma or other benign diseases were used as control. Hematoxylin and eosin (H&E) and Masson's trichrome staining were utilized for histopathological assessment...
2024: PeerJ
https://read.qxmd.com/read/38363001/transcriptomic-analysis-of-porphyromonas-gingivalis-infected-head-and-neck-cancer-cells-identification-of-plau-as-a-candidate-prognostic-biomarker
#22
JOURNAL ARTICLE
Masakazu Hamada, Hiroaki Inaba, Kyoko Nishiyama, Sho Yoshida, Yoshiaki Yura, Michiyo Matsumoto-Nakano, Narikazu Uzawa
Periodontal disease is a risk factor for head and neck squamous cell carcinoma (HNSCC), and Porphyromonas gingivalis, a major periodontal pathogen, has been identified as a specific and potentially independent microbial factor that increases the risk of cancer mortality. Gene expression in HNSCC due to P. gingivalis infection and how changes in gene expression affect the prognosis of HNSCC patients are not clarified. When P. gingivalis was cultured with HNSCC cells, it efficiently adhered to these cells and enhanced their invasive ability...
February 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38356488/chlorogenic-acid-inhibits-progressive-pulmonary-fibrosis-in-a-diabetic-rat-model
#23
JOURNAL ARTICLE
Sagita Mega Sekar Kencana, Nur Arfian, Ratih Yuniartha, Ramadhea Laila Afifa An-Nur Willya Saputri, Fauziyatul Munawaroh, Dwi Cahyani Ratna Sari
BACKGROUND: Chlorogenic acid (CGA) is known to have antifibrotic and hypoglycemic effects and may play a role in preventing diabetes-induced pulmonary fibrosis. This study aimed to determine the effect and optimum dose of CGA on diabetes-induced pulmonary fibrosis. METHODS: Thirty Wistar rats (two-month-old, 150-200 grams) were randomly divided into six groups, namely control, six weeks diabetes mellitus (DM1), eight weeks DM (DM2), and three DM2 groups (CGA1, CGA2, and CGA3) who received CGA doses of 12...
February 2024: Iranian Journal of Medical Sciences
https://read.qxmd.com/read/38338770/semaglutide-modulates-extracellular-matrix-production-of-lx-2-cells-via-exosomes-and-improves-metabolic-dysfunction-associated-steatotic-liver-disease-masld
#24
JOURNAL ARTICLE
Maria Principia Scavo, Giuseppe Lisco, Nicoletta Depalo, Federica Rizzi, Sara Volpe, Valentina Arrè, Livianna Carrieri, Maria Notarnicola, Valentina De Nunzio, Maria Lucia Curri, Giovanni De Pergola, Giuseppina Piazzolla, Gianluigi Giannelli
Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely related to some metabolic disorders, such as central obesity and type 2 diabetes (T2D). Glucagon-like peptide 1 receptor agonists (GLP-1RAs), such as semaglutide, may have therapeutic roles in MASLD associated with T2D. This study aims to investigate the molecular mechanisms underlying the effectiveness of semaglutide on MASLD in terms of progression from liver steatosis to fibrosis. We characterized exosomes from ten patients with type 2 diabetes (T2D) before (T0) and after 12 months (T12) of treatment with once-weekly subcutaneous semaglutide...
January 25, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38336890/imaging-mass-cytometry-analysis-of-becker-muscular-dystrophy-muscle-samples-reveals-different-stages-of-muscle-degeneration
#25
JOURNAL ARTICLE
Patricia Piñol-Jurado, José Verdú-Díaz, Esther Fernández-Simón, Cristina Domínguez-González, Aurelio Hernández-Lain, Conor Lawless, Amy Vincent, Alejandro González-Chamorro, Elisa Villalobos, Alexandra Monceau, Zoe Laidler, Priyanka Mehra, James Clark, Andrew Filby, David McDonald, Paul Rushton, Andrew Bowey, Jorge Alonso Pérez, Giorgio Tasca, Chiara Marini-Bettolo, Michela Guglieri, Volker Straub, Xavier Suárez-Calvet, Jordi Díaz-Manera
Becker muscular dystrophy (BMD) is characterised by fiber loss and expansion of fibrotic and adipose tissue. Several cells interact locally in what is known as the degenerative niche. We analysed muscle biopsies of controls and BMD patients at early, moderate and advanced stages of progression using Hyperion imaging mass cytometry (IMC) by labelling single sections with 17 markers identifying different components of the muscle. We developed a software for analysing IMC images and studied changes in the muscle composition and spatial correlations between markers across disease progression...
February 9, 2024: Scientific Reports
https://read.qxmd.com/read/38324287/clinical-histologic-and-transcriptomic-evaluation-of-sequential-fat-grafting-for-morphea-a-nonrandomized-controlled-trial
#26
JOURNAL ARTICLE
Juzi Liu, Jing Wang, Qian Zhang, Feng Lu, Junrong Cai
IMPORTANCE: Morphea is a rare disease of unknown etiology without satisfactory treatment for skin sclerosis and soft tissue atrophy. OBJECTIVE: To provide clinical, histologic, and transcriptome evidence of the antisclerotic and regenerative effects of sequential fat grafting with fresh fat and cryopreserved stromal vascular fraction gel (SVF gel) for morphea. DESIGN, SETTING, AND PARTICIPANTS: This single-center, nonrandomized controlled trial was conducted between January 2022 and March 2023 in the Department of Plastic and Reconstructive Surgery of Nanfang Hospital, Southern Medical University and included adult participants with early-onset or late-onset morphea who presented with varying degrees of skin sclerosis and soft tissue defect...
February 7, 2024: JAMA Dermatology
https://read.qxmd.com/read/38324114/downregulation-of-lilrb4-promotes-human-aortic-smooth-muscle-cell-contractile-phenotypic-switch-and-apoptosis-in-aortic-dissection
#27
JOURNAL ARTICLE
Jianxian Xiong, Linyuan Wang, Xin Xiong, Yongzhi Deng
Aortic dissection (AD) is a severe vascular disease with high rates of mortality and morbidity. However, the underlying molecular mechanisms of AD remain unclear. Differentially expressed genes (DEGs) were screened by bioinformatics methods. Alterations of histopathology and inflammatory factor levels in β-aminopropionitrile (BAPN)-induced AD mouse model were evaluated through Hematoxylin-Eosin (HE) staining and Enzyme-linked immunosorbent assay (ELISA), respectively. Reverse transcription quantitative real-time polymerase chain reaction was performed to detect DEGs expression...
February 7, 2024: Cardiovascular Toxicology
https://read.qxmd.com/read/38317144/the-sirna-mediated-knockdown-of-ap-1-restores-the-function-of-the-pulmonary-artery-and-the-right-ventricle-by-reducing-perivascular-and-interstitial-fibrosis-and-key-molecular-players-in-cardiopulmonary-disease
#28
JOURNAL ARTICLE
Ioana Karla Comarița, Gabriela Tanko, Iliuță Laurențiu Anghelache, Adriana Georgescu
BACKGROUND: Pulmonary hypertension (PH) is a complex multifactorial vascular pathology characterized by an increased pulmonary arterial pressure, vasoconstriction, remodelling of the pulmonary vasculature, thrombosis in situ and inflammation associated with right-side heart failure. Herein, we explored the potential beneficial effects of treatment with siRNA AP-1 on pulmonary arterial hypertension (PAH), right ventricular dysfunction along with perivascular and interstitial fibrosis in pulmonary artery-PA, right ventricle-RV and lung in an experimental animal model of monocrotaline (MCT)-induced PAH...
February 5, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38315854/phase-separation-of-yap-maml2-differentially-regulates-the-transcriptome
#29
JOURNAL ARTICLE
Chan-I Chung, Junjiao Yang, Xiaoyu Yang, Hongjiang Liu, Zhimin Ma, Frank Szulzewsky, Eric C Holland, Yin Shen, Xiaokun Shu
Phase separation (PS) drives the formation of biomolecular condensates that are emerging biological structures involved in diverse cellular processes. Recent studies have unveiled PS-induced formation of several transcriptional factor (TF) condensates that are transcriptionally active, but how strongly PS promotes gene activation remains unclear. Here, we show that the oncogenic TF fusion Yes-associated protein 1-Mastermind like transcriptional coactivator 2 (YAP-MAML2) undergoes PS and forms liquid-like condensates that bear the hallmarks of transcriptional activity...
February 13, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38311943/-research-of-mir-29a-on-tgf-%C3%AE-1-smad3-pathway-in-pulmonary-fibrosis-induced-by-neodymium-oxide
#30
JOURNAL ARTICLE
Y D Yun, S H Wang
Objective: To exploring the regulatory effect of miR-29a on the transforming growth factor-β1 (TGF-β1) /Smad homolog 3 (Smad3) pathway during the process of rare earth neodymium oxide (Nd(2)O(3)) induced pulmonary fibrosis in mice. Methods: In March 2021, 72 SPF grade C57/BL6J male mice were selected and randomly divided into a control group, Nd(2)O(3) group, Nd(2)O(3)+miR-29a agomir group, and Nd(2)O(3)+NC agomir group, with 18 mice in each group. The Nd(2)O(3) group, Nd(2)O(3)+miR-29a agomir group, and Nd(2)O(3)+NC agomir group were treated with non exposed tracheal instillation, with a dust concentration of 250 mg/ml and a dust volume of 0...
January 20, 2024: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://read.qxmd.com/read/38311169/mcpip1-inhibits-hepatic-stellate-cell-activation-in-autocrine-and-paracrine-manners-preventing-liver-fibrosis
#31
JOURNAL ARTICLE
Natalia Pydyn, Anna Ferenc, Katarzyna Trzos, Ewelina Pospiech, Mateusz Wilamowski, Olga Mucha, Piotr Major, Justyna Kadluczka, Pedro M Rodrigues, Jesus M Banales, Jose M Herranz, Matias A Avila, Tomasz Hutsch, Piotr Malczak, Dorota Radkowiak, Andrzej Budzynski, Jolanta Jura, Jerzy Kotlinowski
BACKGROUND & AIMS: Hepatic fibrosis is characterized by enhanced deposition of extracellular matrix (ECM), which results from the wound-healing response to chronic, repeated injury of any etiology. Upon injury, hepatic stellate cells (HSCs) activate and secrete ECM proteins, forming scar tissue, which leads to liver dysfunction. Monocyte-chemoattractant protein-induced protein 1 (MCPIP1) possesses anti-inflammatory activity, and its overexpression reduces liver injury in septic mice...
February 2, 2024: Cellular and Molecular Gastroenterology and Hepatology
https://read.qxmd.com/read/38308786/examining-the-molecular-mechanisms-of-topiramate-in-alleviating-insulin-resistance-a-study-on-c2c12-myocytes-and-3t3l-1-adipocytes
#32
JOURNAL ARTICLE
Ya-Hui Yang, Xi-Xin Fan, Lichao Ye, Wen-Jian Huang, Chih-Yuan Ko
PURPOSE: Migraine, a severely debilitating condition, may be effectively managed with topiramate, known for its migraine prevention and weight loss properties due to changes in body muscle and fat composition and improved insulin sensitivity. However, the mechanism of topiramate in modulating insulin response in adipocytes and myocytes remains elusive. This study aims to elucidate these molecular mechanisms, offering insights into its role in weight management for migraine sufferers and underpinning its clinical application...
February 3, 2024: Endocrine
https://read.qxmd.com/read/38291510/the-pathogenic-role-of-succinate-sucnr1-a-critical-function-that-induces-renal-fibrosis-via-m2-macrophage
#33
JOURNAL ARTICLE
Min Pu, Jing Zhang, Fuyan Hong, Yan Wang, Chengwei Zhang, Yongcheng Zeng, Zhenzhen Fang, Weiwei Qi, Xia Yang, Guoquan Gao, Ti Zhou
BACKGROUND: Renal fibrosis significantly contributes to the progressive loss of kidney function in chronic kidney disease (CKD), with alternatively activated M2 macrophages playing a crucial role in this progression. The serum succinate level is consistently elevated in individuals with diabetes and obesity, both of which are critical factors contributing to CKD. However, it remains unclear whether elevated succinate levels can mediate M2 polarization of macrophages and contribute to renal interstitial fibrosis...
January 30, 2024: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/38289368/bioinformatic-identification-reveals-a-m6a-binding-protein-igf2bp2-as-a-novel-tumor-promoting-gene-signature-in-thyroid-carcinoma
#34
JOURNAL ARTICLE
Yang Xie, Junqi Xiao, Yong Ying, Jiafeng Liu, Leiying Zhang, Xiangtai Zeng
N6-methyladenosine (m6A) modification plays a crucial role in thyroid carcinoma (THCA). Insulin-like growth factor 2 binding protein 2 (IGF2BP2) is a m6A-binding protein. We aimed to explore the effect of IGF2BP2 on the development of THCA. Differentially expressed genes (DEGs) were screened from GSE50901 and GSE60542 datasets. LinkedOmics, Genebank, and Sequence-based RNA Adenosine Methylation Site Predictor databases were employed to find potential m6A modification sites. Protein-protein interaction network and receiver-operating characteristic curves were applied to determine hub genes of THCA...
January 30, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38283179/developmental-morphogens-direct-human-induced-pluripotent-stem-cells-toward-an-annulus-fibrosus-like-cell-phenotype
#35
JOURNAL ARTICLE
Ana P Peredo, Tonia K Tsinman, Edward D Bonnevie, Xi Jiang, Harvey E Smith, Sarah E Gullbrand, Nathaniel A Dyment, Robert L Mauck
INTRODUCTION: Therapeutic interventions for intervertebral disc herniation remain scarce due to the inability of endogenous annulus fibrosus (AF) cells to respond to injury and drive tissue regeneration. Unlike other orthopedic tissues, such as cartilage, delivery of exogenous cells to the site of annular injury remains underdeveloped, largely due to a lack of an ideal cell source and the invasive nature of cell isolation. Human induced pluripotent stem cells (iPSCs) can be differentiated to specific cell fates using biochemical factors and are, therefore, an invaluable tool for cell therapy approaches...
March 2024: JOR Spine
https://read.qxmd.com/read/38283135/dual-delivery-gene-activated-scaffold-directs-fibroblast-activity-and-keratinocyte-epithelization
#36
JOURNAL ARTICLE
Ashang L Laiva, Fergal J O'Brien, Michael B Keogh
Fibroblasts are the most abundant cell type in dermal skin and keratinocytes are the most abundant cell type in the epidermis; both play a crucial role in wound remodeling and maturation. We aim to assess the functionality of a novel dual gene activated scaffold (GAS) on human adult dermal fibroblasts (hDFs) and see how the secretome produced could affect human dermal microvascular endothelial cells (HDMVECs) and human epidermal keratinocyte (hEKs) growth and epithelization. Our GAS is a collagen chondroitin sulfate scaffold loaded with pro-angiogenic stromal derived factor (SDF-1α) and/or an anti-aging β-Klotho plasmids...
March 2024: APL Bioengineering
https://read.qxmd.com/read/38271362/aerobic-exercise-protects-mi-heart-through-mir-133a-3p-downregulation-of-connective-tissue-growth-factor
#37
JOURNAL ARTICLE
Niu Liu, Zhiping Zhen, Xin Xiong, Yaqi Xue
OBJECTIVE: To investigate the effect of aerobic exercise intervention to inhibit cardiomyocyte apoptosis and thus improve cardiac function in myocardial infarction (MI) mice by regulating CTGF expression through miR-133a-3p. METHODS: Male C57/BL6 mice, 7-8 weeks old, were randomly divided into sham-operated group (S group), sham-operated +aerobic exercise group (SE group), myocardial infarction group (MI group) and MI + aerobic exercise group (ME group). The mice were anesthetized the day after training and cardiac function was assessed by cardiac echocardiography...
2024: PloS One
https://read.qxmd.com/read/38266705/connective-tissue-growth-factor-enhances-tgf-%C3%AE-1-induced-osteogenic-differentiation-via-activation-of-p38-mapk-in-mesenchymal-stem-cells
#38
JOURNAL ARTICLE
Hironori Yoshida, Seiji Yokota, Kazuro Satoh, Akira Ishisaki, Naoyuki Chosa
OBJECTIVES: Cellular differentiation is based on the effects of various growth factors. Transforming growth factor (TGF)-β1 plays a pivotal role in inducing osteogenic differentiation of mesenchymal stem cells (MSCs). In this study, we investigated the influence of connective tissue growth factor (CTGF), known to function synergistically with TGF-β1, on osteogenic differentiation in MSCs. METHODS: UE7T-13 cells were treated with TGF-β1 and/or CTGF...
January 22, 2024: Journal of Oral Biosciences
https://read.qxmd.com/read/38263746/yap1-expression-in-colorectal-cancer-confers-the-aggressive-phenotypes-via-its-target-genes
#39
JOURNAL ARTICLE
Haoyuan Chen, Yangyang Shang, Xia Li, Rongquan Wang
Yes-associated protein1 (YAP1), a downstream effector of the Hippo pathway, is over-expressed in several types of malignancies. We analyzed retrospectively the TCGA database using 447 colorectal cancer (CRC) samples to determine the correlation between YAP1 expression level and CRC patient prognosis. YAP1-enforced expressed CRC cell lines were constructed using the lentivirus particles containing a YAP1 insert. YAP1 was highly expressed in CRC cancerous tissues and is associated with distant metastasis of CRC patients...
January 23, 2024: Cell Cycle
https://read.qxmd.com/read/38262159/porcine-platelet-lysates-exert-the-efficacy-of-chondroregeneration-and-smad2-mediated-anti-chondrofibrosis-on-knee-osteoarthritis
#40
JOURNAL ARTICLE
Xiujuan Xiao, Jiaan Xu, Chen Wang, Zhijiang Jin, Qiang Yuan, Li Zhou, Letian Shan
BACKGROUND: The lack of self-repairability in cartilage and the formation of fibrocartilage pose significant challenges in treating knee osteoarthritis, and there is still no ideal solution. Autologous platelet lysates have been clinically applied to treat kOA and exert satisfactory cartilage-repair efficacy, but the preparation of human PL brings damage to patients and is hardly standardized. METHODS: In this study, porcine PL was developed to replace hPL, and its chondroregenerative and anti-chondrofibrosis effects were explored...
February 15, 2024: International Immunopharmacology
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