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https://www.readbyqxmd.com/read/29909547/modulation-of-mg-2-influx-and-cytoplasmic-free-mg-2-concentration-in-rat-ventricular-myocytes
#1
Michiko Tashiro, Hana Inoue, Masato Konishi
To examine whether TRPM7, a member of the melastatin family of transient receptor potential channels, is a physiological pathway for Mg2+ entry in mammalian cells, we studied the effect of TRPM7 regulators on cytoplasmic free Mg2+ concentration ([Mg2+ ]i ) of rat ventricular myocytes. Acutely isolated single cells were AM-loaded with the fluorescent indicator furaptra, and [Mg2+ ]i was estimated at 25 °C. After [Mg2+ ]i was lowered by soaking the cells with a high-K+ and Mg2+ -Ca2+ -free solution, [Mg2+ ]i was recovered by extracellular perfusion of Ca2+ -free Tyrode's solution that contained 1 mM Mg2+ ...
June 16, 2018: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/29909404/aortic-arch-width-and-cardiovascular-disease-in-men-and-women-in-the-community
#2
Michael L Chuang, Philimon N Gona, Saadia Qazi, Rebecca M Musgrave, Caroline S Fox, Joseph M Massaro, Udo Hoffmann, Christopher J O'Donnell
BACKGROUND: We sought to determine whether increased aortic arch width (AAW) adds to standard Framingham risk factors and coronary artery calcium (CAC) for prediction of incident adverse cardiovascular disease (CVD) events in community-dwelling adults. METHODS AND RESULTS: A total of 3026 Framingham Heart Study Offspring and Third Generation cohort participants underwent noncontrast multidetector computed tomography from 2002 to 2005 to quantify CAC. We measured AAW as the distance between the centroids of the ascending and descending thoracic aorta, at the level of main pulmonary artery bifurcation or the right pulmonary artery...
June 16, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29909401/prevalence-and-long-term-survival-after-coronary-artery-bypass-grafting-in-women-and-men-with-heart-failure-and-preserved-versus-reduced-ejection-fraction
#3
Louise Y Sun, Jack V Tu, Anan Bader Eddeen, Peter P Liu
BACKGROUND: Heart failure (HF) with reduced ejection fraction (rEF) is a widely regarded prognosticator after coronary artery bypass grafting. HF with preserved ejection fraction (pEF) accounts for up to half of all HF cases and is associated with considerable morbidity and mortality in hospitalized cohorts. However, HFpEF outcomes have not been elucidated in cardiac surgical patients. We investigated the prevalence and outcomes of HFpEF and HFrEF in women and men following coronary artery bypass grafting...
June 16, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29909368/long-weekly-working-hours-and-ischaemic-heart-disease-a-follow-up-study-among-145-861-randomly-selected-workers-in-denmark
#4
Harald Hannerz, Ann Dyreborg Larsen, Anne Helene Garde
OBJECTIVES: The aim of the present study was to test if incidences of ischaemic heart disease (IHD) and usage of antihypertensive drugs are independent of weekly working hours (WWH) among full-time employees in Denmark. DESIGN AND PARTICIPANTS: Data on WWH from participants of the Danish labour force surveys, 1999-2013, were linked on an individual level to national registers with data on socioeconomic status (SES), industry, emigrations, redeemed prescriptions, hospital contacts and deaths...
June 15, 2018: BMJ Open
https://www.readbyqxmd.com/read/29909274/molecular-and-functional-analyses-of-novel-anti-lipopolysaccharide-factors-in-giant-river-prawn-macrobrachium-rosenbergii-de-man-and-their-expression-responses-under-pathogen-and-temperature-exposure
#5
Prapansak Srisapoome, Nawanith Klongklaew, Nontawith Areechon, Ratree Wongpanya
Anti-lipopolysaccharide factor (ALF) is an immune-related protein that is crucially involved in immune defense mechanisms against invading pathogens in crustaceans. In the current study, three different ALFs of giant river prawn (Mr-ALF3, Mr-ALF8 and Mr-ALF9) were discovered. Based on sequence analysis, Mr-ALF3 and Mr-ALF9 were identified as new members of ALFs in crustaceans (groups F and G, respectively). Structurally, each newly identified Mr-ALF contained three α-helices packed against a four-stranded β-sheet bearing the LPS-binding motif, which usually binds to the cell wall components of bacteria...
June 14, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29909268/the-relationship-between-intrapartum-cerebroplacental-ratio-and-adverse-perinatal-outcomes-in-term-fetuses
#6
Natthicha Chainarong, Chusana Petpichetchian
OBJECTIVES: The cerebroplacental ratio (CPR) Doppler has been proposed as an instrument for predicting adverse perinatal outcomes particularly during antepartum period. Abnormal CPR is associated with non-reassuring fetal status requiring operative delivery, low Apgar score and neonatal complications. The aim of this study was to assess the role of CPR Doppler in the labor triage suite, so as to identify fetuses at risk for non-reassuring status as well as other adverse perinatal outcomes...
June 11, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29909265/intrapartum-and-perinatal-results-associated-with-different-degrees-of-staining-of-meconium-stained-amniotic-fluid
#7
Vanesa Rodríguez Fernández, Carlos Nicolás López Ramón Y Cajal, Elena Marín Ortiz, Emilio Couceiro Naveira
OBJECTIVE: To determine the intrapartum and perinatal results associated with different degrees of staining of meconium stained amniotic fluid (MSAF). STUDY DESIGN: In a retrospective cohort study of all singleton deliveries over a period of one year (2015) in a tertiary hospital, we compared different degrees of MSAF (yellow, green and thick) to clear amniotic fluids, and analysed in each group maternal, intrapartum and neonatal variables as well as umbilical cord blood gas analysis...
March 20, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29909156/high-dose-influenza-vaccine-to-reduce-clinical-outcomes-in-high-risk-cardiovascular-patients-rationale-and-design-of-the-invested-trial
#8
Orly Vardeny, Jacob A Udell, Jacob Joseph, Michael E Farkouh, Adrian F Hernandez, Alison J McGeer, H Keipp Talbot, Deepak L Bhatt, Christopher P Cannon, Shaun G Goodman, Inder Anand, David L DeMets, Jon Temte, Janet Wittes, Kristin Nichol, Clyde W Yancy, J Michael Gaziano, Lawton S Cooper, KyungMann Kim, Scott D Solomon
BACKGROUND: Influenza leads to significant cardiopulmonary morbidity and mortality-particularly in patients with cardiovascular disease-that may be prevented with a standard influenza vaccine. However, patients with cardiovascular conditions have a reduced immune response to influenza vaccine, potentially resulting in reduced effectiveness for preventing clinical events. High-dose vaccine augments immune response in cardiac patients, suggesting that a high-dose influenza vaccination strategy may further reduce morbidity and mortality...
May 23, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29909114/predicting-survival-from-large-echocardiography-and-electronic-health-record-datasets-optimization-with-machine-learning
#9
Manar D Samad, Alvaro Ulloa, Gregory J Wehner, Linyuan Jing, Dustin Hartzel, Christopher W Good, Brent A Williams, Christopher M Haggerty, Brandon K Fornwalt
OBJECTIVES: The goal of this study was to use machine learning to more accurately predict survival after echocardiography. BACKGROUND: Predicting patient outcomes (e.g., survival) following echocardiography is primarily based on ejection fraction (EF) and comorbidities. However, there may be significant predictive information within additional echocardiography-derived measurements combined with clinical electronic health record data. METHODS: Mortality was studied in 171,510 unselected patients who underwent 331,317 echocardiograms in a large regional health system...
June 9, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29909113/coronary-computed-tomography-angiography-versus-stress-echocardiography-in-acute-chest-pain-a-randomized-controlled-trial
#10
Jeffrey M Levsky, Linda B Haramati, Daniel M Spevack, Mark A Menegus, Terence Chen, Sarah Mizrachi, Durline Brown-Manhertz, Samantha Selesny, Rikah Lerer, Deborah J White, Jonathan N Tobin, Cynthia C Taub, Mario J Garcia
OBJECTIVES: This study sought to compare early emergency department (ED) use of coronary computed tomography angiography (CTA) and stress echocardiography (SE) head-to-head. BACKGROUND: Coronary CTA has been promoted as the early ED chest pain triage imaging method of choice, whereas SE is often overlooked in this setting and involves no ionizing radiation. METHODS: The authors randomized 400 consecutive low- to intermediate-risk ED acute chest pain patients without known coronary artery disease and a negative initial serum troponin level to immediate coronary CTA (n = 201) or SE (n = 199)...
June 8, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29909105/rationale-and-design-of-the-strain-surveillance-of-chemotherapy-for-improving-cardiovascular-outcomes-succour-trial
#11
Tomoko Negishi, Paaladinesh Thavendiranathan, Kazuaki Negishi, Thomas H Marwick
OBJECTIVES: This study sought to evaluate the hypothesis that global longitudinal strain (GLS) guidance of cardioprotective therapy would improve cardiac function of at-risk patients undergoing potentially cardiotoxic chemotherapy, compared with usual care. BACKGROUND: The conventional criteria for diagnosis of chemotherapy-related cardiac dysfunction (CTRCD) are dependent on the recognition of heart failure symptoms and/or changes in left ventricular ejection fraction...
June 8, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29909017/adropin-regulates-pyruvate-dehydrogenase-in-cardiac-cells-via-a-novel-gpcr-mapk-pdk4-signaling-pathway
#12
Dharendra Thapa, Michael W Stoner, Manling Zhang, Bingxian Xie, Janet R Manning, Danielle Guimaraes, Sruti Shiva, Michael J Jurczak, Iain Scott
Mitochondria supply ~90% of the ATP required for contractile function in cardiac cells. While adult cardiomyocytes preferentially utilize fatty acids as a fuel source for oxidative phosphorylation, cardiac mitochondria can switch to other substrates when required. This change is driven in part by a combination of extracellular and intracellular signal transduction pathways that alter mitochondrial gene expression and enzymatic activity. The mechanisms by which extracellular metabolic information is conveyed to cardiac mitochondria are not currently well defined...
June 9, 2018: Redox Biology
https://www.readbyqxmd.com/read/29908945/residual-setup-errors-towards-the-heart-after-image-guidance-linked-with-poorer-survival-in-lung-cancer-patients-do-we-need-stricter-igrt-protocols
#13
Corinne N Johnson, Gareth J Price, Corinne Faivre-Finn, Marianne C Aznar, Marcel van Herk
BACKGROUND: and Purpose: Image-guided radiotherapy (IGRT) is widely used but data directly relating setup errors to patient outcome is scarce. This study investigates the relationship between residual IGRT shifts and overall patient survival, and uses the observed relations to identify structures sensitive to radiation dose. MATERIALS AND METHODS: Residual shift data for 780 NSCLC patients was summarised for each patient over the course of treatment by determining the mean shifts, standard deviations and the vector shift in the direction of the heart...
June 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29908902/a-study-of-generalizability-of-recurrent-neural-network-based-predictive-models-for-heart-failure-onset-risk-using-a-large-and-heterogeneous-ehr-data-set
#14
Laila R Bekhet, Yonghui Wu, Ningtao Wang, Xin Geng, Wenjin Jim Zheng, Fei Wang, Hulin Wu, Hua Xu, Degui Zhi
Recently, recurrent neural networks (RNNs) have been applied in predicting disease onset risks with Electronic Health Record (EHR) data. While these models demonstrated promising results on relatively small data sets, the generalizability and transferability of those models and its applicability to different patient populations across hospitals have not been evaluated. In this study, we evaluated an RNN model, RETAIN, over Cerner Health Facts® EMR data, for heart failure onset risk prediction. Our data set included over 150,000 heart failure patients and over 1,000,000 controls from nearly 400 hospitals...
June 14, 2018: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29908857/midlife-contributors-to-socioeconomic-differences-in-frailty-during-later-life-a-prospective-cohort-study
#15
Eric J Brunner, Martin J Shipley, Sara Ahmadi-Abhari, Carlos Valencia Hernandez, Jessica G Abell, Archana Singh-Manoux, Ichiro Kawachi, Mika Kivimaki
BACKGROUND: Health inequalities persist into old age. We aimed to investigate risk factors for socioeconomic differences in frailty that could potentially be modified through policy measures. METHODS: In this multi-wave longitudinal cohort study (Whitehall II study), we assessed participants' socioeconomic status, behavioural and biomedical risk factors, and disease status at age 45-55 years, and frailty (defined according to the Fried phenotype) at baseline and at one or more of three clinic visits about 18 years later (mean age 69 years [SD 5·9])...
June 13, 2018: Lancet. Public Health
https://www.readbyqxmd.com/read/29908836/dopps-data-suggest-a-possible-survival-benefit-of-renin-angiotensin-aldosterone-system-inhibitors-and-other-antihypertensive-medications-for-hemodialysis-patients
#16
Angelo Karaboyas, Hairong Xu, Hal Morgenstern, Francesco Locatelli, Michel Jadoul, Kosaku Nitta, Indranil Dasgupta, Francesca Tentori, Friedrich K Port, Bruce M Robinson
The benefits of renin angiotensin-aldosterone system inhibitors (RAASi) are well-established in the general population, particularly among those with diabetes, congestive heart failure (CHF), or coronary artery disease (CAD). However, conflicting evidence from trials and concerns about hyperkalemia limit RAASi use in hemodialysis patients, relative to other antihypertensive agents, including beta blockers and calcium channel blockers. Therefore, we investigated prescription patterns and associations with mortality for RAASi and other antihypertensive agents using data from the international Dialysis Outcomes and Practice Patterns Study (DOPPS)...
June 13, 2018: Kidney International
https://www.readbyqxmd.com/read/29908832/cardiac-resynchronization-therapy-guided-by-cardiac-magnetic-resonance-imaging-a-prospective-single-centre-randomized-study-cmr-crt
#17
Radka Kočková, Kamil Sedláček, Dan Wichterle, Viktor Šikula, Jaroslav Tintěra, Helena Jansová, Alena Pravečková, Renata Langová, Lukáš Krýže, Wael El-Husseini, Markéta Segeťová, Josef Kautzner
BACKGROUND: Cardiac resynchronization therapy (CRT) improves symptoms of heart failure (HF), morbidity and mortality in selected population. The aim of the study was to investigate the impact of cardiac magnetic resonance (CMR)-guided left ventricular (LV) lead placement on clinical outcomes and LV reverse remodelling in CRT recipients. METHODS: Patients with CRT indication were randomized for CMR-guided (CMR group) or electrophysiologically guided (EP group) LV lead placement between 2011 and 2014...
June 6, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29908829/pre-hypertension-and-subclinical-cardiac-damage-a-meta-analysis-of-echocardiographic-studies
#18
Cesare Cuspidi, Carla Sala, Marijana Tadic, Elisa Gherbesi, Guido Grassi, Giuseppe Mancia
AIM: The association between pre-hypertension (pre-HTN) and subclinical cardiac damage remains undefined. We performed a systematic meta-analysis of echocardiographic studies in order to provide a comprehensive information on structural and functional cardiac changes in untreated pre-HTN subjects. DESIGN: Studies were identified by crossing the following search terms: "pre-hypertension", "high normal blood pressure" "heart" "left ventricular hypertrophy", "left ventricular function", "diastolic function", "left atrial size", "aortic root size", "echocardiography...
June 8, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29908826/intramyocardial-autologous-cd34-cell-therapy-for-refractory-angina-a-meta-analysis-of-randomized-controlled-trials
#19
Poonam Velagapudi, Mohit Turagam, Dhaval Kolte, Sahil Khera, Omar Hyder, Paul Gordon, Herbert D Aronow, Jane Leopold, J Dawn Abbott
BACKGROUND: Previous studies have demonstrated that intramyocardial human CD34+ cells may relieve symptoms and improve clinical outcomes in chronic refractory angina unresponsive to optimal medical therapy or not amenable to revascularization. METHODS: We performed a meta-analysis of randomized controlled trials (RCTs) to evaluate the impact of human CD34+ cells compared with placebo in chronic refractory angina. Primary efficacy outcomes in our analysis were angina frequency and exercise time...
June 5, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29908771/cognitive-behavioral-therapy-improves-weight-loss-and-quality-of-life-in-women-with-polycystic-ovary-syndrome-a-pilot-randomized-clinical-trial
#20
Laura G Cooney, Lauren W Milman, Liisa Hantsoo, Sara Kornfield, Mary D Sammel, Kelly C Allison, C Neill Epperson, Anuja Dokras
OBJECTIVE: To compare the effects of cognitive-behavioral therapy (CBT) and lifestyle modification (LS) versus LS alone on weight, depressive and anxiety symptoms, and stress response in women with polycystic ovary syndrome (PCOS), overweight/obesity, and depressive symptoms. DESIGN: A 16-week pilot randomized clinical trial. SETTING: Tertiary-care PCOS center. PATIENT(S): Overweight/obese women with PCOS and depressive symptoms...
June 13, 2018: Fertility and Sterility
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