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https://www.readbyqxmd.com/read/29232393/lack-of-association-between-serum-syndecan-4-myocardial-fibrosis-and-ventricular-dysfunction-in-subjects-with-chronic-chagas-disease
#1
Ticiana Ferreira Larocca, Carolina Thé Macêdo, Márcia Noya-Rabelo, Luís Cláudio Lemos Correia, Moisés Imbassahy Moreira, Alessandra Carvalho Caldas, Jorge Andion Torreão, Bruno Solano de Freitas Souza, Juliana Fraga Vasconcelos, Alexandre Schaer Carvalho da Silva, Ricardo Ribeiro Dos Santos, Milena Botelho Pereira Soares
BACKGROUND: Syndecan-4 is a transmembrane glycoprotein associated with inflammation and fibrosis. Increased syndecan-4 levels were previously detected after acute myocardial infarction and in subjects with heart failure. However, the levels of syndecan-4 in subjects with Chagas disease have not so far been investigated. The aim of this study was to investigate the potential role of serum sydencan-4 as a novel biomarker for myocardial fibrosis and cardiac dysfunction in subjects with Chagas disease...
2017: PloS One
https://www.readbyqxmd.com/read/29232369/accelerated-decline-in-cardiac-stem-cell-efficiency-in-spontaneously-hypertensive-rat-compared-to-normotensive-wistar-rat
#2
Sherin Saheera, Renuka R Nair
Cardiac hypertrophy is recognized as an independent risk factor for cardiac failure. Efficient management of hypertensive heart disease requires identification of factors that can possibly mediate the transition from hypertrophy to failure. Resident cardiac stem cells have a prominent role in the maintenance of cardiac tissue homeostasis. Decline in the proportion of healthy cardiac stem cells (CSCs) can affect tissue regeneration. In pathological conditions, apart from natural aging, an adverse microenvironment can lead to decrease in efficiency of CSCs...
2017: PloS One
https://www.readbyqxmd.com/read/29232365/monitoring-compliance-with-standards-of-care-for-chronic-diseases-using-healthcare-administrative-databases-in-italy-strengths-and-limitations
#3
Rosa Gini, Martijn J Schuemie, Alessandro Pasqua, Emanuele Carlini, Francesco Profili, Iacopo Cricelli, Patrizio Dazzi, Valentina Barletta, Paolo Francesconi, Francesco Lapi, Andrea Donatini, Giulia Dal Co, Modesta Visca, Mariadonata Bellentani, Miriam Sturkenboom, Niek Klazinga
BACKGROUND: A recent comprehensive report on healthcare quality in Italy published by the Organization of Economic Co-operation and Development (OECD) recommended that regular monitoring of quality of primary care by means of compliance with standards of care for chronic diseases is performed. A previous ecological study demonstrated that compliance with standards of care could be reliably estimated on regional level using administrative databases. This study compares estimates based on administrative data with estimates based on GP records for the same persons, to understand whether ecological fallacy played a role in the results of the previous study...
2017: PloS One
https://www.readbyqxmd.com/read/29232303/totally-endoscopic-cardiac-surgery-for-atrial-septal-defect-repair-on-beating-heart-without-robotic-assistance-in-25-patients
#4
Quang-Huy Dang, Ngoc-Thanh Le, Cong-Huu Nguyen, Dac-Dai Tran, Do-Hung Nguyen, Trung-Hieu Nguyen, Thi-Hai-Linh Ngo
OBJECTIVE: The aim of the study was to investigate the effectivity and safety of totally endoscopic cardiac surgery without robotic assistance for atrial septal defect (ASD) closure on beating hearts. METHODS: Twenty-five patients (adults/children: 15/10) underwent ASD closure using nonrobotically assisted totally endoscopic approach on beating heart. Three 5-mm trocars and one 12-mm trocar were used, only the superior vena cava is snared, filling the pleural and pericardial cavities with CO2, and the heart was beating during the surgery...
December 7, 2017: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/29232298/use-of-a-new-expanded-polytetrafluoroethylene-multichordal-mitral-apparatus-mitrapatch-to-repair-complex-mitral-valve-lesions
#5
Surendra K Chawla, Muralidhar Padala, W Randolph Chitwood, Robert W M Frater
OBJECTIVE: We report a new expanded polytetrafluoroethylene multichordal mitral apparatus (MitraPatch) to simplify mitral repairs involving multiple cusps and sought to describe the surgical technique and demonstrate the efficacy of the device. METHODS: MitraPatch was laser cut from a single sheet of expanded polytetrafluoroethylene and mounted on a custom-designed handle. Surgical technique to deploy the apparatus on the native mitral valve was developed in ex vivo porcine hearts...
December 7, 2017: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/29232275/complex-decision-making-in-heart-failure-a-systematic-review-and-thematic-analysis
#6
Aimee V Hamel, Joseph E Gaugler, Carolyn M Porta, Niloufar Niakosari Hadidi
BACKGROUND: Heart failure follows a highly variable and difficult course. Patients face complex decisions, including treatment with implantable cardiac defibrillators, mechanical circulatory support, and heart transplantation. The course of decision-making across multiple treatments is unclear yet integral to providing informed and shared decision-making. Recognizing commonalities across treatment decisions could help nurses and physicians to identify opportunities to introduce discussions and support shared decision-making...
December 11, 2017: Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/29232249/clinical-trials-in-valvular-surgery-a-2018-update
#7
Bobby Yanagawa, Amine Mazine, Derrick Y Tam, Subodh Verma
PURPOSE OF REVIEW: There is a growing emphasis on the conduct of large-scale, multicenter randomized controlled trials (RCTs) to guide decision-making in cardiac surgery. Here we review recent landmark RCTs in cardiac valvular surgery. RECENT FINDINGS: RCTs are the gold-standard level of data in medicine. However, there are unique challenges of conducting large-scale surgical trials including funding, blinding, generalizability, nonstandardization of the surgical technique, crossover, among others...
December 11, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29232192/vitamin-e-improved-redox-homeostasis-in-heart-and-aorta-of-hypothyroid-rats
#8
M Hedayati, S Niazmand, M Hosseini, Y Baghcheghi, F Beheshti, S Niazmand
OBJECTIVES: The objective of this study was to evaluate the effect of vitamin E on the oxidative stress parameters and antioxidant defense enzymes in the heart and aorta of 6-n-propylthiouracil (PTU)-induced hypothyroid rats. METHODS: The animals were divided into 4 experimental groups: Group 1 (Euthyroid) received tap water, Group 2 (Hypothyroid) received 0.05 % of PTU in dissolved in their drinking water, Group 3 (PTU+Vit E) hypothyroid rats treated with vitamin E, and Group 4 (Euthyroid+Vit E)...
October 26, 2017: Endocrine Regulations
https://www.readbyqxmd.com/read/29232024/myocardial-perfusion-reserve-index-in-children-with-kawasaki-disease
#9
Richard M Friesen, Michal Schäfer, Pei-Ni Jone, Nana Appiawiah, Daniel Vargas, Brian Fonseca, Michael V DiMaria, Uyen Truong, LaDonna Malone, Lorna P Browne
BACKGROUND: Coronary artery lesions in patients with Kawasaki disease (KD) can impair myocardial perfusion, yet evaluation of perfusion defects by cardiac magnetic resonance (MR) in children is often qualitative. PURPOSE: In this study we aimed to use a quantitative method of myocardial perfusion using stress cardiac MR-derived myocardial perfusion reserve index (MPRI) in children with KD and compare MPRI with ventricular mechanical performance evaluated by cardiac MR strain analysis...
December 12, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29231904/protective-effects-of-%C3%AF-3-pufa-in-anthracycline-induced-cardiotoxicity-a-critical-review
#10
REVIEW
Simona Serini, Renata Ottes Vasconcelos, Renata Nascimento Gomes, Gabriella Calviello
It has been demonstrated that ω-3 polyunsaturated fatty acids (ω-3 PUFA) may exert a beneficial role as adjuvants in the prevention and treatment of many disorders, including cardiovascular diseases and cancer. Particularly, several in vitro and in vivo preclinical studies have shown the antitumor activity of ω-3 PUFA in different kinds of cancers, and several human studies have shown that ω-3 PUFA are able to decrease the risk of a series of cardiovascular diseases. Several mechanisms have been proposed to explain their pleiotropic beneficial effects...
December 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29231770/pharmacological-and-non-pharmacological-treatment-of-obstructive-hypertrophic-cardiomyopathy
#11
Luis F Hidalgo, Srihari S Naidu, Wilbert S Aronow
Hypertrophic obstructive cardiomyopathy has been rising in prevalence, due to increased awareness and advanced imaging. For the symptomatic patient, pharmacological management remains an effective approach to the majority of patients with obstructive hypertrophic cardiomyopathy. However, a significant subset fails to improve sufficiently with medical therapy initially, or progressively becomes more symptomatic despite augmented medications over time. Most of the advances in the treatment of obstructive hypertrophic cardiomyopathy have therefore been made in the area of non-pharmacologic management, particularly septal reduction therapy...
December 12, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29231747/practice-patterns-to-improve-pre-and-post-transplant-medication-adherence-in-heart-transplant-centres-a-secondary-data-analysis-of-the-international-bright-study
#12
Yuliya Senft, Monika Kirsch, Kris Denhaerynck, Fabienne Dobbels, Remon Helmy, Cynthia L Russell, Lut Berben, Sabina De Geest
BACKGROUND: As medication non-adherence is a major risk factor for poor post-transplant outcomes, we explored how adherence is assessed, enhanced and integrated across the transplant continuum. AIM: The aim of this study was to study practice patterns regarding pre- and post-transplant medication adherence assessment and interventions in international heart transplant centres. METHODS: We used data from the Building Research Initiative Group: chronic illness management and adherence in heart transplantation (BRIGHT) study, a cross-sectional study conducted in 36 heart transplant centres in 11 countries...
December 1, 2017: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/29231277/do-individuals-with-intellectual-disability-have-a-lower-peak-heart-rate-and-maximal-oxygen-uptake
#13
Thessa Irena Maria Hilgenkamp, Tracy Baynard
BACKGROUND: Individuals with intellectual disability (ID) have very low physical activity and low peak oxygen uptake (VO2peak ), potentially explained by physiologically lower peak heart rates (HRpeak ). METHOD: The present authors performed a retrospective analysis of a large data set of individuals with intellectual disability (n = 100), with Down syndrome (DS) (n = 48) and without intellectual disability (n = 224) using multiple linear regression analyses, to determine if individuals with intellectual disability exhibit lower HRpeak and VO2peak than individuals without intellectual disability, controlling for age, sex and body mass index (BMI)...
December 12, 2017: Journal of Applied Research in Intellectual Disabilities: JARID
https://www.readbyqxmd.com/read/29231049/heart-rate-recovery-and-cancer-risk-prospective-cohort-study
#14
Yong Hyun Byun, Sang Yeun Kim, Yejin Mok, Youngwon Kim, Sun Ha Jee
PURPOSE: To determine the association between 2-minute heart rate recovery (HRR) and cancer risk. METHODS: Each participant (5379 women; 8485 men) provided HRR obtained from treadmill tests. The outcome was site-specific cancer. RESULTS: Over 9 years of follow-up, 630 cancer events (258 women) were accrued. Slower HRR was associated with increased thyroid cancer risk in women ( P for trend = .0121) and colorectal cancer risk in men ( P for trend = ...
December 1, 2017: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/29230965/prevention-of-chemotherapy-induced-cachexia-by-acvr2b-ligand-blocking-has-different-effects-on-heart-and-skeletal-muscle
#15
Juha J Hulmi, Tuuli A Nissinen, Markus Räsänen, Joni Degerman, Juulia H Lautaoja, Karthik Amudhala Hemanthakumar, Janne T Backman, Olli Ritvos, Mika Silvennoinen, Riikka Kivelä
BACKGROUND: Toxicity of chemotherapy on skeletal muscles and the heart may significantly contribute to cancer cachexia, mortality, and decreased quality of life. Doxorubicin (DOX) is an effective cytostatic agent, which unfortunately has toxic effects on many healthy tissues. Blocking of activin receptor type IIB (ACVR2B) ligands is an often used strategy to prevent skeletal muscle loss, but its effects on the heart are relatively unknown. METHODS: The effects of DOX treatment with or without pre-treatment with soluble ACVR2B-Fc (sACVR2B-Fc) were investigated...
December 11, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29230826/evolution-of-biventricular-loading-condition-in-pediatric-lvad-patient-a-prospective-and-observational-study
#16
Arianna Di Molfetta, Roberta Iacobelli, Sergio Filippelli, Giorgia Grutter, Gianluigi Perri, Francesca Iodice, Luciano Pasquini, Paolo Guccione, Antonio Amodeo
The aim of this study was to describe the echocardiographic trend of left ventricular (LV) and right ventricular (RV) function after implantation of a pulsatile flow left ventricular assist device (LVAD) in children. From 2013 to 2016, we prospectively evaluated 13 consecutive pediatric Berlin Heart EXCOR LVAD patients. Clinical and echocardiographic data were collected at baseline, within 24 h after implantation and monthly until LVAD explant. Median age and weight at the implantation was 8 (4-23) months and 5 (4...
December 12, 2017: Artificial Organs
https://www.readbyqxmd.com/read/29230691/beta-blocker-use-in-pregnancy-and-risk-of-specific-congenital-anomalies-a-european-case-malformed-control-study
#17
Jorieke E H Bergman, L Renée Lutke, Rijk O B Gans, Marie-Claude Addor, Ingeborg Barisic, Clara Cavero-Carbonell, Ester Garne, Miriam Gatt, Kari Klungsoyr, Nathalie Lelong, Catherine Lynch, Olatz Mokoroa, Vera Nelen, Amanda J Neville, Anna Pierini, Hanitra Randrianaivo, Anke Rissmann, David Tucker, Awi Wiesel, Helen Dolk, Maria Loane, Marian K Bakker
INTRODUCTION: The prevalence of chronic hypertension is increasing in pregnant women. Beta-blockers are among the most prevalent anti-hypertensive agents used in early pregnancy. OBJECTIVE: The objective of this study was to investigate whether first-trimester use of beta-blockers increases the risk of specific congenital anomalies in offspring. METHODS: A population-based case-malformed control study was conducted in 117,122 registrations of congenital anomalies from 17 European Concerted Action on Congenital Anomalies and Twins (EUROCAT) registries participating in EUROmediCAT with data for all or part of the period between 1995 and 2013...
December 11, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29230598/multi-view-approach-for-the-diagnosis-of-pulmonary-hypertension-using-transthoracic-echocardiography
#18
Matthias Schneider, Anna Maria Pistritto, Christian Gerges, Mario Gerges, Christina Binder, Irene Lang, Gerald Maurer, Thomas Binder, Georg Goliasch
Pulmonary hypertension (PH) is a disease with severe morbidity and mortality. Echocardiography plays an essential role in the screening of PH. The quality of the acquired continuous wave Doppler signal is the major limitation of the method and can greatly affect the accuracy of estimated pulmonary pressures. The aim of this study was to evaluate the clinical need to image from multiple ultrasound windows in patients with suspected pulmonary hypertension. We prospectively evaluated 65 patients (43% male, mean age 67...
December 11, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29230597/presence-of-post-systolic-shortening-is-an-independent-predictor-of-heart-failure-in-patients-following-st-segment-elevation-myocardial-infarction
#19
Philip Brainin, Sune Haahr-Pedersen, Morten Sengeløv, Flemming Javier Olsen, Thomas Fritz-Hansen, Jan Skov Jensen, Tor Biering-Sørensen
Following an ischemic event post systolic shortening (PSS) may occur. We investigated the association between PSS in patients with ST-segment elevation myocardial infarction (STEMI) following primary percutaneous coronary intervention (pPCI) and occurrence of cardiovascular events at follow-up. A total of 373 patients admitted with STEMI and treated with pPCI were prospectively included in the study cohort. All patients were examined by echocardiography a median of 2 days after admission (interquartile range, 1-3 days)...
December 11, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29230596/distribution-of-potential-eye-and-tissue-donors-within-an-australian-teaching-hospital
#20
Martin J Dutch, Anthony F Denahy
Eye and Tissue donation has the capacity to transform lives, yet the vast majority of potential in-hospital donors are not recognised. Studies which describe the relative importance of specific units or wards in determining the size of the donor pool are limited. The aim of this study was to map the distribution of potential Eye and Tissue donors within the study hospital. A 12-month retrospective analysis of all patient deaths at the study hospital was undertaken. The ability to donate corneal, heart valve, bone and skin tissue was investigated...
December 11, 2017: Cell and Tissue Banking
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