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https://www.readbyqxmd.com/read/29475210/-comparison-of-international-guidelines-for-the-application-of-cardiotocography
#1
Phillip Schulten Sebastian, Jan Philip Suppelna, Timoleon Dagres, Günter Noè, Michael Anapolski, Joscha Reinhard, Harald Krentel, Clemens Tempfer, Sven Schiermeier
OBJECTIVE: This study examines the recommendations of international guidelines on the use of antepartum and intrapartum cardiotocography. MATERIAL AND METHODS: The guidelines of Germany, Canada, UK, USA, Sri Lanka, Australia as well as FIGO have been compared. The recommendations on the use of cardiotocography were separately evaluated for antepartum and intrapartum use. RESULTS: Antepartum: In risk-free pregnancies the use of cardiotocography is not recommended in all countries...
February 23, 2018: Zeitschrift Für Geburtshilfe und Neonatologie
https://www.readbyqxmd.com/read/29475209/perceptually-regulated-exercise-test-allows-determination-of-v%C3%AB-o2max-and-ventilatory-threshold-but-not-respiratory-compensation-point-in-trained-runners
#2
Perrine Truong, Gregoire P Millet, Boris Gojanovic
This study aimed to investigate the differences in maximal oxygen uptake (V̇O2max ) and submaximal thresholds between a standard graded exercise test (GXT) and a perceptually regulated graded exercise test (PRGXT) in trained runners. Eleven well-trained middle- to long-distance runners performed both tests in a randomized order. PRGXT used incremental "clamps" of rating of perceived exertion (RPE) over 10×1-min stages on an automated treadmill equipped with a sonar sensor allowing them to change their running speed instantly and in a natural way...
February 23, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29475048/the-function-of-serpin-2-from-eriocheir-sinensis-in-spiroplasma-eriocheiris-infection
#3
Meijun Yuan, Mingxiao Ning, Panpan Wei, Wenjing Hao, Yunting Jing, Wei Gu, Wen Wang, Qingguo Meng
Serpin families classified serine protease inhibitors regulate various physiological processes. However, there is not study on the role of serpin in immune responses against Spiroplasma eriocheiris as a novel causative pathogen in the Chinese mitten crab, Eriocheir sinensis. In our study, quantitative real-time PCR (qRT-PCR) revealed that the mRNA transcripts of Esserpin-2 were ubiquitous in every tissue, relative higher expression in hepatopancreas, gill and hemocytes, while the intestine, muscle, heart and nerve showed relative lower expression...
February 20, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29474817/activation-of-the-unfolded-protein-response-downregulates-cardiac-ion-channels-in-human-induced-pluripotent-stem-cell-derived-cardiomyocytes
#4
Man Liu, Guangbin Shi, Anyu Zhou, Cassady E Rupert, Kareen L K Coulombe, Samuel C Dudley
RATIONALE: Heart failure is characterized by electrical remodeling that contributes to arrhythmic risk. The unfolded protein response (UPR) is active in heart failure and can decrease protein levels by increasing mRNA decay, accelerating protein degradation, and inhibiting protein translation. OBJECTIVE: Therefore, we investigated whether the UPR downregulated cardiac ion channels that may contribute to arrhythmogenic electrical remodeling. METHODS: Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) were used to study cardiac ion channels...
February 20, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29474816/coffee-for-cardioprotection-and-longevity
#5
REVIEW
James H O'Keefe, James J DiNicolantonio, Carl J Lavie
Coffee, a complex brew containing hundreds of biologically active compounds, exerts potent effects on long-term human health. Recently, a plethora of studies have been published focusing on health outcomes associated with coffee intake. An inverse association between coffee consumption and all-cause mortality has been seen consistently in large prospective studies. Habitual coffee consumption is also associated with lower risks for cardiovascular (CV) death and a variety of adverse CV outcomes, including coronary heart disease (CHD), congestive heart failure (HF), and stroke; coffee's effects on arrhythmias and hypertension are neutral...
February 20, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29474731/a-novel-mutation-of-dipeptidyl-aminopeptidase-like-protein-6-in-a-family-with-suspicious-idiopathic-ventricular-fibrillation
#6
Dong-Bo Ding, Liang-Liang Fan, Zhen Xiao, Hao Huang, Ya-Qin Chen, Shuai Guo, Zhong-Hua Liu, Rong Xiang
Background: Sudden cardiac death (SCD) occurs in a broad spectrum of cardiac pathologies and is an important cause of mortality in the general population. Idiopathic ventricular fibrillation (IVF) is a rare but important factor resulting in SCD. It is diagnosed in a resuscitated cardiac arrest victim underlying unknown cause, with documented ventricular fibrillation. Previous studies have demonstrated that mutations in dipeptidyl aminopeptidase-like protein-6 (DPP6) and cardiac sodium channel Nav1...
February 20, 2018: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29474537/diagnostic-accuracy-of-postmortem-computed-tomography-magnetic-resonance-imaging-and-computed-tomography-guided-biopsies-for-the-detection-of-ischaemic-heart-disease-in-a-hospital-setting
#7
Ivo M Wagensveld, Britt M Blokker, Andrea Pezzato, Piotr A Wielopolski, Nomdo S Renken, Jan H von der Thüsen, Gabriel P Krestin, M G Myriam Hunink, J Wolter Oosterhuis, Annick C Weustink
Aims: The autopsy rate worldwide is alarmingly low (0-15%). Mortality statistics are important, and it is, therefore, essential to perform autopsies in a sufficient proportion of deaths. The imaging autopsy, non-invasive, or minimally invasive autopsy (MIA) can be used as an alternative to the conventional autopsy in an attempt to improve postmortem diagnostics by increasing the number of postmortem procedures. The aim of this study was to determine the diagnostic accuracy of postmortem magnetic resonance imaging (MRI), computed tomography (CT), and CT-guided biopsy for the detection of acute and chronic myocardial ischaemia...
February 20, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29474482/prevalence-of-several-somatic-diseases-depends-on-the-presence-and-severity-of-obstructive-sleep-apnea
#8
Ragnhild L Tveit, Sverre Lehmann, Bjørn Bjorvatn
STUDY OBJECTIVES: The objective was to investigate the prevalence of heart attack, angina pectoris, stroke, hypertension, diabetes mellitus, chronic obstructive pulmonary disease, asthma and obesity in relation to the presence and severity of obstructive sleep apnea. METHODS: The sample consisted of 1887 patients, with mean age of 48.6 years (range 16-83 years), referred to a university hospital on suspicion of obstructive sleep apnea. The patients filled out a questionnaire asking whether they were previously diagnosed with the comorbidities in interest...
2018: PloS One
https://www.readbyqxmd.com/read/29474466/preclinical-pharmacology-of-azd9977-a-novel-mineralocorticoid-receptor-modulator-separating-organ-protection-from-effects-on-electrolyte-excretion
#9
Krister Bamberg, Ulrika Johansson, Karl Edman, Lena William-Olsson, Susanna Myhre, Anders Gunnarsson, Stefan Geschwindner, Anna Aagaard, Anna Björnson Granqvist, Frédéric Jaisser, Yufeng Huang, Kenneth L Granberg, Rasmus Jansson-Löfmark, Judith Hartleib-Geschwindner
Excess mineralocorticoid receptor (MR) activation promotes target organ dysfunction, vascular injury and fibrosis. MR antagonists like eplerenone are used for treating heart failure, but their use is limited due to the compound class-inherent hyperkalemia risk. Here we present evidence that AZD9977, a first-in-class MR modulator shows cardio-renal protection despite a mechanism-based reduced liability to cause hyperkalemia. AZD9977 in vitro potency and binding mode to MR were characterized using reporter gene, binding, cofactor recruitment assays and X-ray crystallopgraphy...
2018: PloS One
https://www.readbyqxmd.com/read/29474460/where-is-the-left-ventricle-during-cardiopulmonary-resuscitation-based-on-chest-computed-tomography-in-the-expiration-with-arms-down-position
#10
Hyuksool Kwon, Yeokoon Kim, Kyuseok Kim, Jae Yun Jung, Joonghee Kim, Sang Il Choi, Eun Ju Chun, Woo Kyung Bae
OBJECTIVE: Patients usually receive cardiopulmonary resuscitation during ventilatory expiration and with their arms down, which does not reflect the normal imaging position. This study used scout images from low-dose chest computed tomography to compare the locations of the left ventricle (LV) in the expiration with arms down position (EAD) and in the full inspirational with arms raised position (IAR). METHODS: This cross-sectional study used a convenience sample and evaluated scout images that were obtained during screening with the participants in the EAD and IAR positions...
2018: PloS One
https://www.readbyqxmd.com/read/29474184/a-review-of-studies-of-quality-of-life-for-chinese-speaking-patients-with-ischemic-heart-disease
#11
REVIEW
Luan Luan, Hao Hu, Shu-Chuen Li
OBJECTIVES: To review published studies of the use of health-related quality-of-life (HRQOL) instruments in patients with ischemic heart disease (IHD) in Chinese-speaking countries/regions, namely, mainland China, Hong Kong, Taiwan, and Singapore. METHODS: Overlapping searching strategy was used for searching three electronic databases-Cochrane Library, MEDLINE, and Embase-from January 1, 1990, to September 30, 2015. After culling, the identified publications were analyzed according to the publication date, the location where the study was conducted, the disease being studied, and the nature of the study (i...
October 18, 2017: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29474098/comparing-four-radiotherapy-techniques-for-treating-the-chest-wall-plus-levels-iii-iv-draining-nodes-after-breast-reconstruction
#12
Valentina Lancellotta, Martina Iacco, Elisabetta Perrucci, Lorenzo Falcinelli, Claudio Zucchetti, Berardino de Bari, Simonetta Saldi, Cynthia Aristei
OBJECTIVE: To compare the dosimetric outcomes of four radiotherapy (RT) techniques for treating the chest wall plus draining nodes after mastectomy and breast reconstruction. METHODS: Three-dimensional conformal radiotherapy (3DCRT), linac-based intensity modulated radiotherapy, helical tomotherapy (HT) and direct tomotherapy (DT) treatments were planned for 40 breast cancer patients. Dose prescription was 50 Gy. Plans were compared in terms of doses to the planning target volume, organs at risk (OARs) and the homogeneity index (HI)...
February 23, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29473948/facilitation-of-ischaemia-induced-ventricular-fibrillation-by-catecholamines-is-mediated-by-%C3%AE-1-and-%C3%AE-2-agonism-in-the-rat-heart-in-vitro
#13
Catherine D E Wilder, Nikoleta Pavlaki, Tutku Dursun, Paul Gyimah, Ellice Caldwell-Dunn, Antonella Ranieri, Hannah R Lewis, Michael J Curtis
BACKGROUND & PURPOSE: Antiarrhythmic β-blockers are used in patients at risk of myocardial ischaemia, but the survival benefit and mechanisms are unclear. We hypothesised that β-blockers do not prevent ventricular fibrillation (VF), but instead inhibit the ability of catecholamines to facilitate ischaemia-induced VF, limiting the scope of their usefulness. EXPERIMENTAL APPROACH: ECGs were analysed from ischaemic Langendorff-perfused rat hearts perfused with adrenoceptor antagonists and/or exogenous catecholamines (313 nM noradrenaline+75 nM adrenaline; CATs) in a blinded and randomised study...
February 23, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29473846/epigallocatechin-gallate-reduces-ischemia-reperfusion-injury-in-isolated-perfused-rabbit-hearts
#14
Aida Salameh, Roxana Schuster, Ingo Dähnert, Johannes Seeger, Stefan Dhein
Cardioplegic arrest during heart operations is often used in cardiac surgery. During cardioplegia, the heart is subjected to a global ischemia/reperfusion-injury. (-)-epigallocatechin gallate (EGCG), one of the main ingredients of green tea, seems to be beneficial in various cardiac diseases. Therefore, the aim of our study was to evaluate EGCG in a rabbit model of cardioplegic arrest. Twenty four mature Chinchilla rabbits were examined. Rabbit hearts were isolated and perfused according to Langendorff. After induction of cardioplegia (without and with 20 µmol/L EGCG, n = 6 each) the hearts maintained arrested for 90-min...
February 23, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29473817/na-h-exchanger-isoform-1-induced-osteopontin-expression-facilitates-cardiac-hypertrophy-through-p90-ribosomal-s6-kinase
#15
Nabeel Abdulrahman, Béatrice Jaspard Vinassa, Larry Fliegel, Ayesha Jabeen, Sadaf Riaz, Alain-Pierre Gadeau, Fatima Mraiche
Cardiovascular diseases are the leading cause of death worldwide. One in three cases of heart failure is due to dilated cardiomyopathy. The Na+ /H+ exchanger isoform 1 (NHE1), a multifunctional protein and the key pH regulator in the heart, has been demonstrated to be increased in this condition. We have previously demonstrated that elevated NHE1 activity induced cardiac hypertrophy in vivo. Furthermore, the overexpression of active NHE1 elicited modulation of gene expression in cardiomyocytes including an upregulation of myocardial osteopontin (OPN) expression...
February 23, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29473759/contribution-of-nontraditional-lipid-profiles-to-reduced-glomerular-filtration-rate-in-h-type-hypertension-population-of-rural-china
#16
Haoyu Wang, Zhao Li, Xiaofan Guo, Yintao Chen, Shuang Chen, Yichen Tian, Yingxian Sun
BACKGROUND: Despite current interest in the unfavorable impact of nontraditional lipid profiles on cardiovascular disease, information regarding its relations to reduced glomerular filtration rate (GFR) in H-type hypertension population has not been systemically elucidated. METHODS: Analyses were based upon a cross-sectional study of 3259 participants with H-type hypertension who underwent assessment of biochemical, anthropometric, and blood pressure values. Reduced GFR was considered if meeting estimated GFR< 60 ml/min/1...
February 23, 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29473649/detection-of-tilapia-lake-virus-tilv-infection-by-pcr-in-farmed-and-wild-nile-tilapia-oreochromis-niloticus-from-lake-victoria
#17
K K Mugimba, A A Chengula, S Wamala, E D Mwega, C J Kasanga, D K Byarugaba, R H Mdegela, S Tal, B Bornstein, A Dishon, S Mutoloki, L David, Ø Evensen, H M Munang'andu
Tilapia lake virus disease (TiLVD) has emerged to be an important viral disease of farmed Nile tilapia (Oreochromis niloticus) having the potential to impede expansion of aquaculture production. There is a need for rapid diagnostic tools to identify infected fish to limit the spread in individual farms. We report the first detection of TiLV infection by PCR in farmed and wild Nile tilapia from Lake Victoria. There was no difference in prevalence between farmed and wild fish samples (p = .65), and of the 442 samples examined from 191 fish, 28 were positive for TiLV by PCR...
February 23, 2018: Journal of Fish Diseases
https://www.readbyqxmd.com/read/29473644/the-atrial-fibrillation-health-literacy-information-technology-system-pilot-assessment
#18
Jared W Magnani, Courtney L Schlusser, Everlyne Kimani, Bruce L Rollman, Michael K Paasche-Orlow, Timothy W Bickmore
Background: Atrial fibrillation (AF) is a highly prevalent heart rhythm condition that has significant associated morbidity and requires chronic treatment. Mobile health (mHealth) technologies have the potential to enhance multiple aspects of AF care, including education, monitoring of symptoms, and encouraging and tracking medication adherence. We have previously implemented and tested relational agents to improve outcomes in chronic disease and sought to develop a smartphone-based relational agent for improving patient-centered outcomes in AF...
July 2017: JMIR Cardio
https://www.readbyqxmd.com/read/29473532/the-promising-pharmacological-effects-and-therapeutic-medicinal-applications-of-punica-granatum-l-pomegranate-as-a-functional-food-in-humans-and-animals
#19
Kuldeep Dhama
BACKGROUND: Punica granatum L (pomegranate), is a shrub mostly available in the Mediterranean Sea region. The fruits have gained the substantial attention among researchers due to its promising biological activities including anti-inflammatory, antibacterial, antidiarrheal, immune modulatory, antitumor, wound healing and antifungal that have been attributed to various constituents of seeds, bark, juice, pericarp and leaf of this tree across the globe. The phenolic compounds of pomegranate have been documented to possess numbers of prophylactic and therapeutic utilities against various pathological infections as well as non-infectious disorders...
February 21, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/29473372/risk-factors-for-benign-prostatic-enlargement-the-role-of-lifestyle-habits-at-younger-age-the-controllati2017-initiative-study-group
#20
Vincenzo Mirone, Giuseppe Carrieri, Giuseppe Morgia, Luca Carmignani, Giuseppe Vespasiani, Fabio Parazzini, Walter Artibani
OBJECTIVE: The risk factors for benign prostatic enlargement (BPE) are not well understood and particularly few data are available from Italian population. MATERIALS AND METHODS: This was an observational cross sectional study aimed to examine the association between several risk factors and BPE. During the "#Controllati2017" initiative, men aged 18 years or more were invited to attend participating urologic centers for a free of charge visit for counseling about urologic or andrologic conditions...
December 31, 2017: Archivio Italiano di Urologia, Andrologia
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