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https://www.readbyqxmd.com/read/27914167/statistical-considerations-for-reporting-and-planning-heart-rate-variability-case-control-studies
#1
Daniel S Quintana
The calculation of heart rate variability (HRV) is a popular tool used to investigate differences in cardiac autonomic control between population samples. When interpreting effect sizes to quantify the magnitude of group differences, researchers typically use Cohen's guidelines of small (0.2), medium (0.5), and large (0.8) effects. However, these guidelines were originally proposed as a fallback for when the effect size distribution (ESD) was unknown. Despite the availability of effect sizes from hundreds of HRV studies, researchers still largely rely on Cohen's guidelines to interpret effect sizes and to perform power analyses to calculate required sample sizes for future research...
December 3, 2016: Psychophysiology
https://www.readbyqxmd.com/read/27914158/causes-of-death-in-an-acute-psychiatric-inpatient-unit-of-a-portuguese-general-hospital
#2
Sofia Barbosa, Márcia Sequeira, Sara Castro, Rita Manso, Catarina Klut Câmara, Bruno Trancas, Nuno Borja-Santos, Teresa Maia
INTRODUCTION: Psychiatric patients are at increased risk of death from a number of natural and unnatural causes. This study examines the mortality causes of all psychiatric inpatients of an acute psychiatric unit at a general hospital in Portugal for sixteen years (1998 to 2013). MATERIAL AND METHODS: Twenty-one inpatients died at the inpatient unit between 1998 and 2013 (average 1.3 per year). A retrospective study through case-file review was carried to collect demographic characteristics, medical and psychiatry diagnosis...
August 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/27913834/key-role-of-pacing-site-as-determinant-factor-of-exercise-testing-performance-in-pediatric-patients-with-chronic-ventricular-pacing
#3
Michel Cabrera Ortega, Hiram Tápanes Duamy, Dunia B Benítez Ramos
Chronic right ventricular (RV) apical pacing has been associated with deterioration of functional capacity and chronotropic incompetence during exercise testing in children. The effects of alternative pacing site on exercise performance in pediatric population remain unknown. We evaluated the influence of ventricular pacing site on exercise capacity in pediatric patients with complete congenital atrioventricular block requiring permanent pacemaker therapy. Sixty-four children paced from RV apex (n = 26), RV midseptum (n = 15) and left ventricular (LV) apex (n = 23) were studied cross-sectionally...
December 2, 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27913766/myocardial-cytochrome-oxidase-activity-increases-with-age-and-hypoxemia-in-patients-with-congenital-heart-disease
#4
Michael Onwugbufor, Richard J Levy, David Zurakowski, Richard A Jonas, Pranava Sinha
BACKGROUND: Myocardial tolerance to ischemia is influenced by age and preoperative cyanosis through unknown mechanisms and significantly affects postoperative outcomes. Cytochrome c oxidase (CcOx), the terminal enzyme of the mitochondrial electron transport chain, may play a role in the susceptibility to ischemic-reperfusion (IR) injury. Our study aimed at investigating changes in human myocardial CcOx activity based on age and preoperative oxygen saturation to understand its role in transition from neonatal to mature myocardium and hypoxic conditions...
December 1, 2016: Perfusion
https://www.readbyqxmd.com/read/27913605/non-alcoholic-fatty-liver-disease-is-associated-with-early-left-ventricular-dysfunction-in-childhood-acute-lymphoblastic-leukaemia-survivors
#5
Maurizio Delvecchio, Paola Muggeo, Mariantonietta Monteduro, Giuseppe Lassandro, Chiara Novielli, Federica Valente, Emanuela Salinaro, Annapaola Zito, Marco Matteo Ciccone, Vito Leonardo Miniello, Nicola Santoro, Paola Giordano, Maria Felicia Faienza
BACKGROUND: Childhood acute lymphoblastic leukaemia (ALL) survivors have an increased risk of metabolic and cardiovascular disease. We aimed to assess the presence of non-alcoholic fatty liver disease (NAFLD) in childhood ALL and if it is associated with early cardiovascular dysfunction. METHODS: In total, 53 childhood ALL survivors and 34 controls underwent auxological evaluation, biochemical assay, liver, heart and vascular ultrasound study. RESULTS: NAFLD was more frequent in ALL patients than in controls (39...
February 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27913560/cohort-profile-the-diabetes-tuberculosis-treatment-outcome-ditto-study-in-pakistan
#6
Fatima Mukhtar, Zahid A Butt
PURPOSE: Pakistan is faced with an increasing prevalence of diabetes in addition to its existing high burden of tuberculosis (TB). Diabetes has a detrimental effect on treatment outcomes of patients with TB, which may hinder achieving the goals of the End-TB strategy by 2030. We conducted a prospective cohort study to determine difference between treatment outcomes among patients with diabetes and new pulmonary tuberculosis (PTB) and patients without diabetes and new PTB. This would help generate contextual and valid scientific evidence from a developing country like Pakistan with its unique interplay of sociocultural, economic and health system factors to inform policy and practice...
December 2, 2016: BMJ Open
https://www.readbyqxmd.com/read/27913558/providing-additional-information-about-the-benefits-of-statins-in-a-leaflet-for-patients-with-coronary-heart-disease-a-qualitative-study-of-the-impact-on-attitudes-and-beliefs
#7
Rebecca Dickinson, David K Raynor, Peter Knapp, Jan MacDonald
OBJECTIVE: To explore the impact of providing additional information about the potential benefits of simvastatin in a patient leaflet on attitudes and beliefs. DESIGN: Interview-based study using a generic qualitative approach and framework analysis. PARTICIPANTS: 21 participants receiving a prescription for simvastatin were recruited from a general practitioner practice (from a total of 120). 8 participants were women; the age range was 55-92...
December 2, 2016: BMJ Open
https://www.readbyqxmd.com/read/27913338/intracardiac-vortex-dynamics-by-high-frame-rate-doppler-vortography-i-in-vivo-i-comparison-with-vector-flow-mapping-and-4-d-flow-mri
#8
Julia Faurie, Mathilde Baudet, Kondo Claude Assi, Dominique Auger, Guillaume Gilbert, Francois Tournoux, Damien Garcia
Recent studies have suggested that intracardiac vortex flow imaging could be of clinical interest to early diagnose the diastolic heart function. Doppler vortography has been intro-duced as a simple color Doppler method to detect and quantify intraventricular vortices. This method is able to locate a vortex core based on the recognition of an antisymmetric pattern in the Doppler velocity field. Because the heart is a fast-moving organ, high frame rates are needed to decipher the whole blood vortex dynamics during diastole...
November 29, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/27913059/cha2ds2-vasc-scores-and-major-bleeding-in-patients-with-nonvalvular-atrial-fibrillation-who-are-receiving-rivaroxaban
#9
W Frank Peacock, Sally Tamayo, Manesh Patel, Nicholas Sicignano, Kathleen P Hopf, Zhong Yuan
STUDY OBJECTIVE: Assessing stroke risk associated with nonvalvular atrial fibrillation depends on the evaluation of patient characteristics and clinical features. Clinicians must determine that the net clinical benefit from anticoagulation therapy outweighs its risk, namely, bleeding. Risk assessment for stroke is commonly performed by calculating a CHA2DS2-VASc (congestive heart failure/left ventricular dysfunction, hypertension, ≥75 years, diabetes mellitus, previous stroke or transient ischemic attack or thromboembolism, vascular disease, aged 65 to 74 years, sex female) score...
November 29, 2016: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/27913009/quantitative-changes-in-late-gadolinium-enhancement-at-cardiac-magnetic-resonance-in-the-early-phase-of-acute-myocarditis
#10
Enrico Ammirati, Francesco Moroni, Paola Sormani, Angelica Peritore, Angela Milazzo, Giuseppina Quattrocchi, Manlio Cipriani, Fabrizio Oliva, Cristina Giannattasio, Maria Frigerio, Alberto Roghi, Paolo G Camici, Patrizia Pedrotti
BACKGROUND: The presence of late gadolinium enhancement (LGE) at cardiac magnetic resonance (CMR) has diagnostic and prognostic value in patients with acute myocarditis (AM). Aim of our study was to quantify the changes in LGE extension (LGE%) early after AM and evaluate its relations with biventricular function and morphology. METHODS: We investigated 76 consecutive patients with AM (acute onset of chest pain/heart failure/ventricular arrhythmias not explained by other causes, and raised troponin) that met CMR criteria based on myocardial oedema at T2-weighted images and LGE on post-contrast images at median time of 6days from onset of symptoms...
November 23, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27913008/microrna-98-plays-a-critical-role-in-experimental-myocarditis
#11
Xiao Chen, Shuo Dong, Ningning Zhang, Liang Chen, Mao-Gang Li, Ping-Chang Yang, Jiangping Song
BACKGROUND AND AIMS: Myocarditis is inflammation in the heart; its pathogenesis is to be further investigated. Activities of micro RNAs (miR) are associated with immune inflammation. This study tests a hypothesis that miR-98 is involved in the development of myocarditis. METHODS: BALB/c mice were immunized with cardiac α-myosin heavy chain peptides (MyHC-α) to induce myocarditis. The effects of miR-98 on regulation of interleukin (IL)-10 were assessed by real time RT-PCR...
November 23, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27913006/noninvasive-prediction-of-pulmonary-artery-pressure-and-vascular-resistance-by-using-cardiac-magnetic-resonance-indices
#12
Zhang Zhang, Meng Wang, Zhenwen Yang, Fan Yang, Dong Li, Tielian Yu, Ningnannan Zhang
BACKGROUND: Cardiac magnetic resonance (CMR) has promise of being able to provide frequent cardiac morphology and function evaluations noninvasively for repeated follow-ups of pulmonary arterial hypertension (PAH) patients after the initial right heart catheterization (RHC) diagnosis. By using the noninvasive CMR indices, the present study aimed to formulate and validate a prediction model of mean pulmonary artery pressure (mPAP) and pulmonary vascular resistance (PVR). METHODS: Both Derivation Cohort (N=25) and Validation Cohort (N=25) of PAH patients underwent CMR and RHC within one week...
October 29, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27912961/the-effect-of-chinese-herbal-medicine-on-hemorrhagic-shock-a-systematic-review-and-meta-analysis
#13
REVIEW
Da-Long Wang, Xiao-Guang Lu, Wen-Xiu Guo, Tuo Chen, Yi Song, Zhi-Wei Fan
BACKGROUND: Chinese herbal medicine (CHM) has been widely used in the treatment of hemorrhagic shock (HS) in China. Many controlled trials have been undertaken to investigate its efficacy. OBJECTIVE: To evaluate the effectiveness and safety of CHM for Hemorrhagic Shock patients. METHODS: We screening the Web of ScienceDirect database, PubMed, the Cochrane Library, EMBASE, China Biomedical Database web (CBM), China National Knowledge Infrastructure (CNKI) and WanFang database (WF), from inception to January 2015...
December 2016: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/27912960/music-intervention-during-daily-weaning-trials-a-6-day-prospective-randomized-crossover-trial
#14
Zhan Liang, Dianxu Ren, JiYeon Choi, Mary Beth Happ, Marylyn Hravnak, Leslie A Hoffman
PURPOSE: To examine the effect of patient-selected music intervention during daily weaning trials for patients on prolonged mechanical ventilation. METHODS: Using a crossover repeated measures design, patients were randomized to music vs no music on the first intervention day. Provision of music was alternated for 6 days, resulting in 3 music and 3 no music days. During weaning trials on music days, data were obtained for 30min prior to music listening and continued for 60min while patients listened to selected music (total 90min)...
December 2016: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/27912948/therapeutic-efficacy-of-traditional-chinese-medicine-kuan-sin-yin-in-patients-undergoing-chemotherapy-for-advanced-colon-cancer-a-controlled-trial
#15
Tsai-Ju Chien, Chia-Yu Liu, Ruey-Hwa Lu, Chin-Wei Kuo, Yang-Chao Lin, Chung-Hua Hsu
BACKGROUND: Traditional Chinese Medicine (TCM) has been used increasingly as complementary medicine in cancer care. Kuan-Sin-Yin (KSY) is a TCM decoction containing seven herbs known to cause immunomodulation or anticancer activity, and which are associated with the TCM concept of Qi and energy supply. Kuan-Sin-Yin has cytostatic effects on cancer cells in animal models. OBJECTIVE: The aim of this study is to evaluate the level of improvement in meridian energy and heart-rate variability (HRV) and to assess whether these observations are compatible with TCM theory...
December 2016: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/27912926/acute-management-of-refractory-and-unstable-pediatric-supraventricular-tachycardia
#16
Jonathan Lewis, Gaurav Arora, Dana L Tudorascu, Robert W Hickey, Richard A Saladino, Mioara D Manole
OBJECTIVE: To characterize the management of acute pediatric supraventricular tachycardia (SVT), placing special emphasis on infants, patients refractory to adenosine (refractory SVT), and patients with hypotension, poor perfusion, or altered mental status (unstable SVT). STUDY DESIGN: Retrospective cohort study of patients 0-18 years of age without congenital heart disease who presented to our pediatric hospital from January 2003 to December 2012 for the treatment of acute SVT...
November 22, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27912902/evolution-of-the-clinical-profile-of-patients-with-acute-heart-failure-treated-in-spanish-emergency-departments
#17
R Escoda, Ò Miró, F J Martín-Sánchez, J Jacob, P Herrero, V Gil, J M Garrido, M J Pérez-Durá, M Fuentes, P Llorens
OBJECTIVE: To analyse the changes in epidemiology, outpatient and emergency department clinical care, and outcomes of patients treated for acute heart failure (AHF) in Spanish hospital emergency departments (HEDs) between 2007 and 2014. METHOD: A multicentre cohort study was conducted that consecutively included patients with AHF diagnosed in 9HEDs during 4 periods (2007, 2009, 2011 and 2014). The study analysed the changes observed in 20 variables corresponding to baseline data, outpatient care and emergency care data and outcome data...
November 29, 2016: Revista Clínica Española
https://www.readbyqxmd.com/read/27912745/ganoderma-lucidum-beta-1-3-1-6-glucan-as-an-immunomodulator-in-inflammation-induced-by-a-high-cholesterol-diet
#18
Yu-Sheng Wu, Shu-Ying Ho, Fan-Hua Nan, Shiu-Nan Chen
BACKGROUND: Binding of beta 1,3/1,6 glucan of Ganoderma lucidum (G. lucidum) with the receptor results in a series of signal transfers (signalling cascades), which activates the transcription factors for regulating inflammation. Excess cholesterol intake leads to an increase in the distance between fat cells and capillaries, which may cause hypoxia in the fat tissue of obese mice. This hypoxia induces the death of fat cells, resulting in the inflammation of adipose tissue or an increase in the inflammatory gene expression associated with obesity...
December 3, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27912212/knockdown-of-inhibitory-guanine-nucleotide-binding-protein-gi%C3%AE-2-by-antisense-oligodeoxynucleotides-attenuates-the-development-of-hypertension-and-tachycardia-in-spontaneously-hypertensive-rats
#19
Yousra Ali El-Basyuni, Yuan Li, Madhu B Anand-Srivastava
BACKGROUND: We previously showed that the levels of both Giα-2 and Giα-3 proteins were augmented in spontaneously hypertensive rats (SHRs) before the onset of hypertension. In addition, intraperitoneal injection of pertussis toxin, which inactivates both Giα proteins, prevented the development of hypertension in SHRs. The aim of the present study was to determine the specific contributions of Giα-2 and Giα-3 proteins to the development of hypertension. METHODS AND RESULTS: Antisense oligodeoxynucleotide of Giα-2 and Giα-3 encapsulated in PEG/DOTAP/DOPE cationic liposomes were administrated intravenously into 3-week-old prehypertensive SHRs and Wistar Kyoto rats, whereas the control Wistar Kyoto rats and SHRs received PBS, empty liposomes, or sense...
October 26, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27912210/relative-contributions-of-arterial-stiffness-and-hypertension-to-cardiovascular-disease-the-framingham-heart-study
#20
Teemu J Niiranen, Bindu Kalesan, Naomi M Hamburg, Emelia J Benjamin, Gary F Mitchell, Ramachandran S Vasan
BACKGROUND: The presence and implications of abnormal arterial stiffness, a potential independent predictor of outcomes, in community-dwelling treated hypertensives is unknown. Furthermore, limited data exist regarding the risk of cardiovascular disease (CVD) associated with arterial stiffness across the entire range of blood pressure. METHODS AND RESULTS: We measured carotid-femoral pulse wave velocity (PWV) and classical CVD risk factors in 2127 community-dwelling participants (mean age 60 years, 57% women) of The Framingham Offspring Cohort...
October 26, 2016: Journal of the American Heart Association
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