keyword
https://read.qxmd.com/read/37366553/corrigendum-to-article-cp203292
#21
JOURNAL ARTICLE
Cecilia Fernández Del Valle-Laisequilla, Cristian Trejo-Jasso, Juan Carlos Huerta-Cruz, Lina Marcela Barranco-Garduño, Juan Rodríguez-Silverio, Héctor Isaac Rocha-González, Juan Gerardo Reyes-García
Cecilia Fernández Del Valle-Laisequilla, Cristian Trejo-Jasso, Juan Carlos Huerta-Cruz, Lina Marcela Barranco-Garduño, Juan Rodríguez-Silverio, Héctor Isaac Rocha-González, Juan Gerardo Reyes-García. Efficacy and safety of a fixed-dose combination of D-norpseudoephedrine, triiodothyronine, atropine, aloin, and diazepam in obese patients. Int J Clin Pharmacol Ther. 2018; 56: 531-538. doi: 10.5414/CP203292. Note from the authors: We realized only now that the affiliation of Cecilia Fernández Del Valle-Laisequilla was indicated in the title page, but due to an unintentional mistake in the final version, the affiliation was not declared in the conflict of interest section, which should read: "Cecilia Fernández Del Valle-Laisequilla is Medical Director of Productos Medix S...
June 27, 2023: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/37353337/current-perspectives-of-pharmacotherapies-for-copd
#22
JOURNAL ARTICLE
Roy A Pleasants, James F Donohue
Pharmacotherapies and avoidance of environmental/inhaled toxins are core to managing COPD. Compared to the drugs available 50 years ago, there has been substantial progress with COPD pharmacotherapies, but gaps in adherence and inhaler use persist. Personalizing inhaled pharmacotherapies is now possible with digital technologies by objectively documenting adherence and guiding inhaler technique. Another means to improve existing pharmacotherapies is through phenotyping and biomarkers. This is especially important considering the heterogeneity of the disease COPD...
July 2023: Respiratory Care
https://read.qxmd.com/read/37297746/copd-patients-behaviour-when-involved-in-the-choice-of-inhaler-device
#23
JOURNAL ARTICLE
Sorin Bivolaru, Ancuta Constantin, Constantin Marinel Vlase, Cristian Gutu
BACKGROUND: Inhaler therapy plays a crucial role in controlling respiratory symptoms in patients with chronic obstructive pulmonary disease (COPD). Incorrect or partially correct use of inhaler devices causes many chronic obstructive pulmonary disease (COPD) patients to continue to have respiratory symptoms due to poor drug deposition in the airways as a result of poor inhaler technique, leading to increased healthcare costs due to exacerbations and multiple emergency room presentations...
May 30, 2023: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/37259713/author-correction-hyaluronic-acid-accelerates-re-epithelialization-and-healing-of-acute-cutaneous-wounds
#24
JOURNAL ARTICLE
F De Francesco, A Saparov, M Riccio
Correction to: Eur Rev Med Pharmacol Sci 2023; 27(3 Suppl): 37-45. doi: 10.26355/eurrev_202304_31320-PMID: 37129334-published online on April 27, 2023. After publication, the authors found some transcription mistakes and applied minor corrections to the Abstract and Discussion sections. The sections have been amended as follows: -       Abstract section: "an average 80% decrease" has been corrected in "an average 86% decrease"; "a small amount of exudate was noted in 91% of wounds" has been corrected in "a small amount of exudate was noted in 10% of wounds"...
May 2023: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/37238395/antiarrhythmic-drug-dosing-in-children-review-of-the-literature
#25
REVIEW
Nathalie Oeffl, Lukas Schober, Patrick Faudon, Sabrina Schweintzger, Martin Manninger, Martin Köstenberger, Hannes Sallmon, Daniel Scherr, Stefan Kurath-Koller
Antiarrhythmic drugs represent a mainstay of pediatric arrhythmia treatment. However, official guidelines and consensus documents on this topic remain scarce. There are rather uniform recommendations for some medications (including adenosine, amiodarone, and esmolol), while there are only very broad dosage recommendations for others (such as sotalol or digoxin). To prevent potential uncertainties and even mistakes with regard to dosing, we summarized the published dosage recommendations for antiarrhythmic drugs in children...
May 8, 2023: Children
https://read.qxmd.com/read/37122576/patient-centricity-design-and-conduct-of-clinical-trials-in-orphan-diseases-third-of-three-sets-of-expanded-proceedings-from-the-2020-isctm-autumn-conference-on-pediatric-drug-development
#26
JOURNAL ARTICLE
Joan Busner, Gahan Pandina, Simon Day, Atul Mahableshwarkar, Lucas Kempf, Maria Sheean, Judith Dunn
This article expands on a session, titled "Patient Centricity: Design and Conduct of Clinical Trials in Orphan Diseases," that was presented as part of a two-day meeting on Pediatric Drug Development at the International Society for Central Nervous System (CNS) Clinical Trials and Methodology (ISCTM) Autumn Conference in Boston, Massachusetts, in October 2020. Speakers from various areas of pediatric drug development addressed a variety of implications of including children in drug development programs, including implications for rare/orphan diseases...
2023: Innovations in Clinical Neuroscience
https://read.qxmd.com/read/37094453/reasons-for-medication-administration-errors-barriers-to-reporting-them-and-the-number-of-reported-medication-administration-errors-from-the-perspective-of-nurses-a-cross-sectional-survey
#27
JOURNAL ARTICLE
Iva Brabcová, Hana Hajduchová, Valerie Tóthová, Ivana Chloubová, Martin Červený, Radka Prokešová, Josef Malý, Jiří Vlček, Martin Doseděl, Kateřina Malá-Ládová, Ondřej Tesař, Susan O'Hara
UNLABELLED: The aim of the study was to identify the reasons for medication administration errors, describe the barriers in their reporting and estimate the number of reported medication administration errors. BACKGROUND: Providing quality and safe healthcare is a key priority for all health systems. Medication administration error belongs to the more common mistakes committed in nursing practice. Prevention of medication administration errors must therefore be an integral part of nursing education...
April 11, 2023: Nurse Education in Practice
https://read.qxmd.com/read/37035625/case-report-fatal-cerebral-herniation-caused-by-hypoglycemic-due-to-mistaking-glibenclamide-in-children
#28
Chunlan Song, Wanyu Jia, Shengli Shi, Peng Li
In recent years, the prevalence of diabetes in China has significantly increased, and glibenclamide is widely used as a basic hypoglycemic drug in China's primary clinical practice. There are many left-behind children in the grass-roots areas in China and various dangerous incidents of children taking drugs by mistake continue to occur. This article reports a case of cerebral edema and fatal cerebral hernia caused by hypoglycemia induced by mistakenly ingesting glibenclamide in a child. This is the first reported case in China of a child who died from brain herniation caused by accidental administration of glibenclamide...
2023: Frontiers in Behavioral Neuroscience
https://read.qxmd.com/read/37018330/prescribing-errors-in-a-brazilian-teaching-hospital-causes-and-underlying-factors-from-the-perspective-of-junior-doctors
#29
JOURNAL ARTICLE
Gislaine F Bonella, Letícia da S Alves, Alicia R N D de Souza, Carlos H M da Silva
INTRODUCTION: In university hospital settings most prescriptions are written by junior doctors, who are more likely to make prescribing errors than experienced doctors. Prescribing errors can cause serious harm to patients and drug harm differs among low, middle and high-income countries. In Brazil, few studies have investigated the causes of these errors. Our aim was to explore medication prescribing errors in a teaching hospital, their causes, and underlying factors from the perspective of junior doctors...
2023: PloS One
https://read.qxmd.com/read/36949766/analysis-of-the-nature-and-contributory-factors-of-medication-safety-incidents-following-hospital-discharge-using-national-reporting-and-learning-system-nrls-data-from-england-and-wales-a-multi-method-study
#30
JOURNAL ARTICLE
Fatema A Alqenae, Douglas Steinke, Andrew Carson-Stevens, Richard N Keers
INTRODUCTION: Improving medication safety during transition of care is an international healthcare priority. While existing research reveals that medication-related incidents and associated harms may be common following hospital discharge, there is limited information about their nature and contributory factors at a national level which is crucial to inform improvement strategy. AIM: To characterise the nature and contributory factors of medication-related incidents during transition of care from secondary to primary care...
2023: Therapeutic Advances in Drug Safety
https://read.qxmd.com/read/36869191/inappropriate-use-of-statistical-power
#31
EDITORIAL
Raphael A Fraser
We are pleased to add this typescript, Inappropriate use of statistical power by Raphael Fraser to the BONE MARROW TRANSPLANTATION Statistics Series. The authour discusses how we sometimes misuse statistical analyses after a study is completed and analyzed to explain the results. The most egregious example is post hoc power calculations.When the conclusion of an observational study or clinical trial is negative, namely, the data observed (or more extreme data) fail to reject the null hypothesis, people often argue for calculating the observed statistical power...
March 3, 2023: Bone Marrow Transplantation
https://read.qxmd.com/read/36852239/an-evaluation-of-the-use-of-inhalers-in-asthma-and-chronic-obstructive-pulmonary-disease
#32
JOURNAL ARTICLE
Seçil Çakmaklı, Ayşe Özdemir, Hikmet Fırat, Cenk Aypak
OBJECTIVES: Inhaled therapy is the treatment of choice for obstructive lung diseases such as asthma and chronic obstructive pulmonary disease (COPD). However, the maximum benefit from such therapy depends on the correct use of inhaler devices. In this study, our primary aim was to evaluate inhaler techniques in patients with asthma and COPD in order to identify common errors. In addition, we investigated the effect of various parameters on the rate of inhaler misuse. METHODS: We enrolled a total of 300 asthma/COPD patients, who presented at the Chest Diseases and Family Medicine Outpatient Clinics of a tertiary hospital located in Ankara, Turkey...
August 2023: Journal of Taibah University Medical Sciences
https://read.qxmd.com/read/36837928/molnupiravir-a-versatile-prodrug-against-sars-cov-2-variants
#33
REVIEW
Divya Teli, Pankti Balar, Kishan Patel, Anu Sharma, Vivek Chavda, Lalit Vora
The nucleoside analog β-D- N 4-hydroxycytidine is the active metabolite of the prodrug molnupiravir and is accepted as an efficient drug against COVID-19. Molnupiravir targets the RNA-dependent RNA polymerase (RdRp) enzyme, which is responsible for replicating the viral genome during the replication process of certain types of viruses. It works by disrupting the normal function of the RdRp enzyme, causing it to make mistakes during the replication of the viral genome. These mistakes can prevent the viral RNA from being transcribed, converted into a complementary DNA template, translated, or converted into a functional protein...
February 20, 2023: Metabolites
https://read.qxmd.com/read/36824288/the-effect-of-exhalation-before-the-inhalation-of-dry-powder-aerosol-drugs-on-the-breathing-parameters-emitted-doses-and-aerosol-size-distributions
#34
JOURNAL ARTICLE
Árpád Farkas, Gábor Tomisa, Szilvia Kugler, Attila Nagy, Attila Vaskó, Erika Kis, Georgina Szénási, Gabriella Gálffy, Alpár Horváth
Airway deposition of aerosol drugs is highly dependent on the breathing manoeuvre of the patients. Though incorrect exhalation before the inhalation of the drug is one of the most common mistakes, its effect on the rest of the manoeuvre and on the airway deposition distribution of aerosol drugs is not explored in the open literature. The aim of the present work was to conduct inhalation experiments using six dry powder inhalers in order to quantify the effect of the degree of lung emptying on the inhalation time, inhaled volume and peak inhalation flow...
December 2023: International journal of pharmaceutics: X
https://read.qxmd.com/read/36822984/pediatric-poisonings-associated-with-ingestion-of-marijuana-products
#35
JOURNAL ARTICLE
Bart Hammig, Ches Jones, Sydney Haldeman
BACKGROUND: Rapid changes in marijuana legislation have resulted in a wider array of products containing tetrahydrocannabinol (THC) to be legally manufactured and sold, such as edibles in the form of gummy candies and cookies. These products may be enticing to young children who mistake them for typical snack foods. OBJECTIVE: Our aim was to describe emergency department (ED) visits due to unintentional ingestion of cannabis products among children aged birth to 11 years old in the United States...
February 2023: Journal of Emergency Medicine
https://read.qxmd.com/read/36808327/long-noncoding-rna-itgb1-promotes-migration-and-invasion-of-clear-cell-renal-cell-carcinoma-by-downregulating-mcl-1
#36
JOURNAL ARTICLE
X-L Zheng, Y-Y Zhang, W-G Lv
The article "Long noncoding RNA ITGB1 promotes migration and invasion of clear cell renal cell carcinoma by downregulating Mcl-1", by X.-L. Zheng, Y.-Y. Zhang, W.-G. Lv, published in Eur Rev Med Pharmacol Sci 2019; 23 (5): 1996-2002-DOI: 10.26355/eurrev_201903_17238-PMID: 30915742 has been retracted by the author for the following reasons: After the publication of this article, the authors reviewed the process of the experiment and found there were mistakes in the study setting. Authors state that the cancer tissues of 60 inpatients collected in the article included cancer tissues and adjacent tissues...
February 2023: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/36763053/screening-for-bilayer-active-and-likely-cytotoxic-molecules-reveals-bilayer-mediated-regulation-of-cell-function
#37
JOURNAL ARTICLE
Thasin A Peyear, Olaf S Andersen
A perennial problem encountered when using small molecules (drugs) to manipulate cell or protein function is to assess whether observed changes in function result from specific interactions with a desired target or from less specific off-target mechanisms. This is important in laboratory research as well as in drug development, where the goal is to identify molecules that are unlikely to be successful therapeutics early in the process, thereby avoiding costly mistakes. We pursued this challenge from the perspective that many bioactive molecules (drugs) are amphiphiles that alter lipid bilayer elastic properties, which may cause indiscriminate changes in membrane protein (and cell) function and, in turn, cytotoxicity...
April 3, 2023: Journal of General Physiology
https://read.qxmd.com/read/36734696/retraction-note-linc01296-promotes-the-proliferation-and-invasion-by-regulating-microrna-760-expression-and-predicts-poor-prognosis-of-hepatocellular-carcinoma
#38
JOURNAL ARTICLE
Z-C Wang, S Yang, M-Q Chen, S-S Wu, H-H Lv, W-X Jin
The article "LINC01296 promotes the proliferation and invasion by regulating microRNA-760 expression and predicts poor prognosis of hepatocellular carcinoma", by Z.-C. Wang, S. Yang, M.-Q. Chen, S.-S. Wu, H.-H. Lv, W.-X. Jin, published in Eur Rev Med Pharmacol Sci 2019; 23 (22): 9848-9856-DOI: 10.26355/eurrev_201911_19548- PMID: 31799652 has been retracted by the author for the following reasons: After the publication of this article, the authors reviewed the process of the experiment and found there were mistakes in the methodology search...
January 2023: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/36694396/self-correction-is-essential-to-science-author-s-response
#39
JOURNAL ARTICLE
Kishor Patwardhan
I thank R Srivatsan [1] and Shailaja Chandra [2] for commenting on my reflective article [3]. While it is true that the scientific establishment has, on many occasions, betrayed the public trust because of the power and money associated with it, the same cannot be said of "science" as such. Science is an idea that places evidence-based thinking above everything else while understanding a phenomenon. The results of this endeavour often depend on how well people apply it in different situations. Thalidomide and Rofecoxib could be taken as two examples where the biomedical sciences have disappointed the public [4]...
2023: Indian Journal of Medical Ethics
https://read.qxmd.com/read/36694393/police-investigation-and-unethical-scientific-interrogation
#40
JOURNAL ARTICLE
Jinee Lokaneeta
Shraddha Walkar's horrific murder has rekindled the urgent issue of domestic violence and violence against women in India [1]. With women's bodies often becoming part of a larger ideological and political narrative, Walkar's brutal murder was given a communal turn due to the interfaith nature of the relationship. The most visible manifestation of this was the attack by members of the Hindu Sena on the accused, Aaftab, while being taken from the forensic lab to Tihar jail [2], in the name of "protecting their women"...
2023: Indian Journal of Medical Ethics
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