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https://www.readbyqxmd.com/read/29783113/automated-uhplc-separation-of-10-pharmaceutical-compounds-using-software-modeling
#1
A Zöldhegyi, H-J Rieger, I Molnár, L Fekhretdinova
Human mistakes are still one of the main reasons of underlying regulatory affairs that in a compliance with FDA's Data Integrity and Analytical Quality by Design (AQbD) must be eliminated. To develop smooth, fast and robust methods that are free of human failures, a state-of-the-art automation was presented. For the scope of this study, a commercial software (DryLab) and a model mixture of 10 drugs were subjected to testing. Following AQbD-principles, the best available working point was selected and conformational experimental runs, i...
March 20, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29691274/negative-myoclonus-secondary-to-paroxetine-intake
#2
Pedro Correia, Joana Afonso Ribeiro, Conceição Bento, Francisco Sales
Outside the context of overdose and serotonin syndrome, seizures and myoclonic movements attributed to selective serotonin reuptake inhibitors (SSRIs) are rare and poorly documented. We present a 77-year-old man, with no history of epilepsy, presenting in the emergency department with whole body jerks since that morning. Two days earlier, due to a prescription mistake, he was started on paroxetine 20 mg instead of his usual fluoxetine 20 mg. The patient's electroencephalogram (EEG), performed in the emergency department, revealed a bilateral synchronous parieto-occipital fast spike activity pattern, which correlated consistently with negative myoclonus...
April 24, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29676652/-here-s-to-a-night-of-drunken-mistakes-exploring-experiences-regrets-and-optimism-in-young-adult-drinkers
#3
Emma L Davies, Mary Sissons Joshi
BACKGROUND: Studies exploring "anticipated regret" concerning alcohol rarely consider the broader consequences of excessive drinking that might be regretted. Even if specific regrettable experiences are identified, interventions targeting them may not succeed because individuals are often optimistic about their risk susceptibility. OBJECTIVES: This study examined the consequences young adult drinkers reported, and the extent to which these were regretted...
April 20, 2018: Substance Use & Misuse
https://www.readbyqxmd.com/read/29556886/intravenous-lipid-emulsion-overdose-in-infancy-a-case-report-and-overview-of-opportunities-challenges-and-prevention
#4
REVIEW
Wasim Khasawneh, Salar Bani Hani
Medication errors remain among the major problems seen in hospitals. Such errors can relate to the prescription, dispensation, or administration of drugs. Human factors account for most of these mistakes, but other factors such as infusion pump programming defects should always be considered. Worldwide, medication errors have been reported to affect 2-30% of patients, depending on the institution. Intravenous lipid emulsion (ILE) infusion is frequently used as part of total parenteral nutrition in patients of all ages with feeding and gastrointestinal issues...
March 19, 2018: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/29550092/-vitamine-k-antagonists-overdose-physician-adherence-to-the-french-guidelines
#5
E Oliosi, O Pointeau, E Mazoyer, S Le Jeune, B Giroux-Leprieur, R Dhôte, J J Mourad
INTRODUCTION: Vitamin K antagonists (VKA) are drugs with a major risk of side effect. Guidelines have been published in 2008 by the Haute Autorité de santé (HAS) concerning the management of an excessively elevated INR ratio. Our research aimed to assess physicians' adherence to those guidelines. METHODS: We realized a retrospective, multicentric study. One hundred and ten cases of excessively elevated INR ratio were identified and analyzed. RESULTS: Overall physicians adherence was 58%...
March 14, 2018: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29524084/correction-to-preparation-of-controlled-release-particles-based-on-spherical-porous-silica-used-as-the-drug-carrier-by-the-dry-coating-method
#6
Shohei Nakamura, Shihoko Kondo, Ayaka Mohri, Takatoshi Sakamoto, Hiroshi Yuasa
In the present notation, the formula names and the formulas (page 7, left column, lines 20-21) do not correspond to each other. It is a completely incorrect description, due to a typesetting mistake by the publisher. See below for details. The original article has been corrected.
March 9, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29484008/seborrheic-pemphigus-antigen-mimicry-and-the-subsequent-wrong-diagnostic-and-therapeutic-approach
#7
Anastasiya Atanasova Chokoeva, Ilia Lozev, Irina Yungareva, Uwe Wollina, Torello Lotti, Georgi Konstantinov Maximov, Georgi Tchernev
It is well-established that drugs could be leading cause of occurrence of numerous diseases, including pemphigus, being either inducer or triggering factor of the autoimmunity. Despite medications, it should be kept in mind that chronic or acute infections are also capable of being a trigger in various types of cutaneous eruptions, including pemphigus. The rapidly obtained and uncompleted history for accompanied medication leads to general mistakes in the subsequent treatment approach, as the first step in such cases is discontinuation of the drug-inductor...
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29460557/-errors-in-medicine-perceptions-of-nursing-students-in-rome
#8
Massimiliano Chiarini, Emilia De Vita, Angela Meggiolaro, Silvia Miccoli, Gaetana Maria Grazia Stricchiola, Giuseppe Alberto Grande, Maria Luisa Veneziano, Anna Santa Guzzo, Giuseppe La Torre
INTRODUCTION: The error in medicine has long been discussed in scientific debates. The purpose of this study is to evaluate the degree knowledge, attitude and behavior of students in Nursing for the failure in the health sector. METHODS: It was administered to 231 students of Nursing of the Sapienza University of Rome (171 females and 60 males), aged between 21 and 45 years, a structured questionnaire in three questions that explore the experiences and opinions about the errors found in medical practice, the causes underlying them and the mistakes that should never be committed...
October 2017: Professioni Infermieristiche
https://www.readbyqxmd.com/read/29434543/altered-functional-connectivity-of-fronto-cingulo-striatal-circuits-during-error-monitoring-in-adolescents-with-a-history-of-childhood-abuse
#9
Heledd Hart, Lena Lim, Mitul A Mehta, Charles Curtis, Xiaohui Xu, Gerome Breen, Andrew Simmons, Kah Mirza, Katya Rubia
Childhood maltreatment is associated with error hypersensitivity. We examined the effect of childhood abuse and abuse-by-gene ( 5-HTTLPR, MAOA ) interaction on functional brain connectivity during error processing in medication/drug-free adolescents. Functional connectivity was compared, using generalized psychophysiological interaction (gPPI) analysis of functional magnetic resonance imaging (fMRI) data, between 22 age- and gender-matched medication-naïve and substance abuse-free adolescents exposed to severe childhood abuse and 27 healthy controls, while they performed an individually adjusted tracking stop-signal task, designed to elicit 50% inhibition failures...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29379812/characteristics-of-the-traumatic-forensic-cases-admitted-to-emergency-department-and-errors-in-the-forensic-report-writing
#10
Nurettin Aktas, Umut Gulacti, Ugur Lok, İrfan Aydin, Tayfun Borta, Murat Celik
Objective: To identify errors in forensic reports and to describe the characteristics of traumatic medico-legal cases presenting to the emergency department (ED) at a tertiary care hospital. Methods: This study is a retrospective cross-sectional study. The study includes cases resulting in a forensic report among all traumatic patients presenting to the ED of Adiyaman University Training and Research Hospital, Adiyaman, Turkey during a 1-year period. We recorded the demographic characteristics of all the cases, time of presentation to the ED, traumatic characteristics of medico-legal cases, forms of suicide attempt, suspected poisonous substance exposure, the result of follow-up and the type of forensic report...
January 2018: Bulletin of Emergency and Trauma
https://www.readbyqxmd.com/read/29303355/nitroimidazoles-as-hypoxic-cell-radiosensitizers-and-hypoxia-probes-misonidazole-myths-and-mistakes
#11
Peter Wardman
Nitroimidazoles have been extensively explored as hypoxic cell radiosensitizers but have had limited clinical success, with efficacy restricted by toxicity. However, they have proven clinically useful as probes for tumour hypoxia. Both applications, and probably much of the dose-limiting toxicities, reflect the dominant chemical property of electron affinity or ease of reduction, associated with the nitro substituent in an aromatic structure. This single dominant property affords unusual, indeed extraordinary flexibility in drug or probe design, suggesting further development is possible in spite of earlier limitations, in particular building on the benefit of hindsight and an appreciation of errors made in earlier studies...
March 20, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29295971/special-k-with-no-license-to-kill-accidental-ketamine-overdose-on-induction-of-general-anesthesia
#12
Lindsay L Warner, Nathan Smischney
BACKGROUND Ketamine is used as an induction and sedation agent in emergency departments and operating rooms throughout the country. Despite its widespread clinical use, there are few cases of significant morbidity and mortality attributed to ketamine overdose in the clinical setting. CASE REPORT The anesthesia provider in the room was an oral maxillofacial surgeon who inadvertently took out a more highly concentrated bottle of ketamine that is typically used for pediatric patients. The patient received 950 mg (100 mg/ml concentration) of intravenous ketamine instead of the intended 95 mg (10 mg/ml concentration)...
January 3, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29237326/a-chamber-of-errors-adaptation-to-assess-pharmaceutical-assistants-knowledge-in-chemotherapy-preparation
#13
C Loboda, J Vigneron, C Mulot, I May, B Demore
French preparation guidelines state that pharmacy staff who manipulate cytotoxic drugs have to follow specific training. In order to assess the pharmaceutical assistants' skills and knowledge, we developed a "Cytotoxic Preparation Centralized Unit (CPCU) of errors," derived from the Canadian concept of "Chamber of horrors." A table listing 20 mistakes to track down was created and each pharmaceutical assistant spent 20 min in the "CPCU of errors" with the pharmacist, who wrote down the spotted mistakes in real time...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29204766/correction-to-informing-materials-drugs-as-tools-for-exploring-cancer-mechanisms-and-pathways
#14
Etienne Vignola-Gagné, Peter Keating, Alberto Cambrosio
The original version of this article unfortunately contained a mistake. Three entries are incorrect in the reference list. The corrected references are given below.
December 4, 2017: History and Philosophy of the Life Sciences
https://www.readbyqxmd.com/read/29166038/theory-of-polyelectrolyte-complexation-complex-coacervates-are-self-coacervates
#15
Kris T Delaney, Glenn H Fredrickson
The complexation of mixtures of cationic and anionic polymers to produce complex-coacervate phases is a subject of fundamental importance to colloid and polymer science as well as to applications including drug delivery, sensing technologies, and bio-inspired adhesives. Unfortunately the theoretical underpinnings of complex coacervation are widely misunderstood and conceptual mistakes have propagated in the literature. Here, a simple symmetric polyelectrolyte mixture model in the absence of salt is used to discuss the salient features of the phase diagram, including the location of the critical point, binodals, and spinodals...
June 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29162776/erratum-for-sushi-repeat-containing-protein-x-linked-2-promotes-angiogenesis-through-the-urokinase-type-plasminogen-activator-receptor-dependent-integrin-%C3%AE-v%C3%AE-3-focal-adhesion-kinase-pathways-by-liu-kl-et-al-drug-discov-ther-2017-11-4-212-217
#16
(no author information available yet)
In the article entitled "Sushi repeat-containing protein X-linked 2 promotes angiogenesis through the urokinase-type plasminogen activator receptor dependent integrin αvβ3/focal adhesion kinase pathways" by Liu KL et al. (Drug Discov Ther. 2017; 11(4):212-217.), a mistake in Figure 3a (αvβ3) has been identified. Figure 3 is printed below.
2017: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/29141983/are-parents-who-feel-the-need-to-watch-over-their-children-s-care-better-patient-safety-partners
#17
Elizabeth D Cox, Kristofer Hansen, Victoria P Rajamanickam, Roger L Brown, Paul J Rathouz, Pascale Carayon, Lori L DuBenske, Linda A Buel, Michelle M Kelly
OBJECTIVES: Many parents report needing to watch over their child's hospital care to prevent mistakes. In this study, we assessed whether needing to watch over care predicts parent performance of recommended safety behaviors to reduce medication errors and health care-associated infections. METHODS: At admission, we surveyed 170 parents about their need to watch over care, demographics, and hospitalization factors. At discharge, parents were surveyed about medication awareness and hand hygiene behaviors...
December 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/29140767/genomic-medicine-without-borders-which-strategies-should-developing-countries-employ-to-invest-in-precision-medicine-a-new-fast-second-winner-strategy
#18
Konstantinos Mitropoulos, David N Cooper, Christina Mitropoulou, Spiros Agathos, Jürgen K V Reichardt, Fatima Al-Maskari, Wasun Chantratita, Ambroise Wonkam, Collet Dandara, Theodora Katsila, Catalina Lopez-Correa, Bassam R Ali, George P Patrinos
Genomic medicine has greatly matured in terms of its technical capabilities, but the diffusion of genomic innovations worldwide faces significant barriers beyond mere access to technology. New global development strategies are sorely needed for biotechnologies such as genomics and their applications toward precision medicine without borders. Moreover, diffusion of genomic medicine globally cannot adhere to a "one-size-fits-all-countries" development strategy, in the same way that drug treatments should be customized...
November 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29115074/adapter-based-safety-injection-system-for-prevention-of-wrong-route-and-wrong-patient-medication-errors
#19
Yong Chan Cho, Seung Ho Lee, Yang Hyun Cho, Young Bin Choy
Wrong-route or -patient medication errors due to human mistakes have been considered difficult to resolve in clinical settings. In this study, we suggest a safety injection system that can help to prevent an injection when a mismatch exists between the drug and route or patient. For this, we prepared two distinct adapters with key and keyhole patterns specifically assigned to a pair of drug and route or patient. When connected to a syringe tip and its counterpart, a catheter injection-port, respectively, the adapters allowed for a seamless connection only with their matching patterns...
December 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29099732/error-in-drugs-consumption-among-older-patients
#20
Yosefa Bar-Dayan, Thomas Shotashvily, Mona Boaz, Julio Wainstein
The cost effectiveness of generic drugs has promoted their use worldwide. However, the large variety of bioequivalent generic and brand-name drugs found in the marketplace increases the complexity and frequency of mistakes in drug consumption. This clinical study investigated the prevalence of various mistakes in drug consumption by patients using a hospital setting. This prospective clinical trial used a hospital setting to identify errors in drug consumption. Six hundred patients who were hospitalized for a minimum of 48 hours in the Internal Medicine Departments were checked at various time points...
November 2017: American Journal of Therapeutics
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