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https://www.readbyqxmd.com/read/27921426/-gestational-diabetes-mellitus
#1
Hana Krejčí
The present generation of women of childbearing age more frequently suffer from overweight, obesity, initial as well as fully established metabolic syndrome, which together with postponing motherhood until the third decade in life plays an important role in the increasing incidence of gestational diabetes (GDM) that currently affects about 1/5 of pregnant women. However the causal link between diabetes during pregnancy and metabolic diseases in the whole population is mutual. By way of epigenetic changes, maternal diabetes unfavourably programmes metabolism of the offspring, who tend to transfer the disorder to the next generations...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27819782/-dynamic-long-term-and-institutional-psychotherapy-to-treat-persistent-depressive-disorders
#2
Jorge Garibay
BACKGROUND: Major depression is a public health problem that threatens to become the second leading cause of disability in the world. In this study we show the results obtained once we applied a psychodynamic psychotherapeutic and long-term process in patients with major depressive disorder, attending a public health institution (PHI). METHODS: From a list of female volunteers, we randomly selected 30 patients who met the diagnostic criteria of major depression...
November 2016: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/27757060/omics-approaches-to-individual-variation-modeling-networks-and-the-virtual-patient
#3
Hans Lehrach
Every human is unique. We differ in our genomes, environment, behavior, disease history, and past and current medical treatment-a complex catalog of differences that often leads to variations in the way each of us responds to a particular therapy. We argue here that true personalization of drug therapies will rely on "virtual patient" models based on a detailed characterization of the individual patient by molecular, imaging, and sensor techniques. The models will be based, wherever possible, on the molecular mechanisms of disease processes and drug action but can also expand to hybrid models including statistics/machine learning/artificial intelligence-based elements trained on available data to address therapeutic areas or therapies for which insufficient information on mechanisms is available...
September 2016: Dialogues in Clinical Neuroscience
https://www.readbyqxmd.com/read/27737012/satisfaction-in-older-persons-and-general-practitioners-during-the-implementation-of-integrated-care
#4
Antonius J Poot, Monique A A Caljouw, Claudia S de Waard, Annet W Wind, Jacobijn Gussekloo
BACKGROUND: Integrated care for older persons with complex care needs is widely advocated. Particularly professionals and policy makers have positive expectations. Care outcome results are ambiguous. Receiver and provider satisfaction is relevant but still poorly understood. METHODS: During implementation of integrated care in residential homes (The MOVIT project), we compared general satisfaction and satisfaction with specific aspects of General Practitioner (GP) care in older persons and GPs before (cohort I) and after at least 12 months of implementation (cohort II)...
2016: PloS One
https://www.readbyqxmd.com/read/27716124/safer-drug-use-in-primary-care-a-pilot-intervention-study-to-identify-improvement-needs-and-make-agreements-for-change-in-five-swedish-primary-care-units
#5
Sara Modig, Cecilia Lenander, Nina Viberg, Patrik Midlöv
BACKGROUND: There is an urgent need to improve patient safety in the area of medication treatment among the elderly. The aim of this study was to explore which improvement needs and strengths, relating to medication safety, arise from a multi-professional intervention in primary care and further to describe and follow up on the agreements for change that were established within the intervention. METHODS: The SÄKLÄK project was a multi-professional intervention in primary care consisting of self-assessment, peer-review, feedback and written agreements for change...
October 4, 2016: BMC Family Practice
https://www.readbyqxmd.com/read/27611098/authentication-of-schisandra-chinensis-and-schisandra-sphenanthera-in-chinese-patent-medicines
#6
Pin Jiang, Yan Lu, Daofeng Chen
Authentication of species is crucial for ensuring the safety and efficacy of herbal medicines. The fruits of Schisandra chinensis and S. sphenanthera have been used for the same traditional Chinese drug, Wuweizi, but are found to be quite different according to their constituents, pharmacological effects, and qualities. These two fruits have been recorded as Schisandrae Chinensis Fructus (Wuweizi) and Schisandrae Sphenantherae Fructus (Nan-wuweizi), respectively, by Chinese Pharmacopoeia, 2000 edition. However, Nan-wuweizi is often found to be taken as Wuweizi in some Chinese patent drugs intentionally or by mistake because of its lower price and similar characteristics to Wuweizi...
November 30, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27580621/characterising-and-comparing-drug-dispensing-practices-at-animal-health-outlets-in-the-rift-valley-kenya-an-exploratory-analysis-part-ii
#7
L E Higham, W Ongeri, K Asena, M V Thrusfield
A mixed-method study was conducted in the Rift Valley of Kenya to characterise drug-dispensing practices amongst staff at animal health outlets and to explore perceptions of veterinary medicines amongst pastoralists and farmers. Forty structured questionnaires were administered to staff at animal health outlets, including franchise outlets of 'Sidai Africa Ltd.', and two focus group discussions were facilitated to explore the perceptions of local animal health services by a Maasai pastoralist group and a dairy farmer cooperative...
December 2016: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/27566436/tmseg-novel-prediction-of-transmembrane-helices
#8
Michael Bernhofer, Edda Kloppmann, Jonas Reeb, Burkhard Rost
Transmembrane proteins (TMPs) are important drug targets because they are essential for signaling, regulation, and transport. Despite important breakthroughs, experimental structure determination remains challenging for TMPs. Various methods have bridged the gap by predicting transmembrane helices (TMHs), but room for improvement remains. Here, we present TMSEG, a novel method identifying TMPs and accurately predicting their TMHs and their topology. The method combines machine learning with empirical filters...
November 2016: Proteins
https://www.readbyqxmd.com/read/27540218/rates-and-types-of-prescribing-errors-and-related-interventions-in-paediatric-oncology
#9
Claire Fosbrook
AIM: The aim of the pharmacy intervention audit was to prospectively record the number and type of interventions made to paediatric oncology chemotherapy prescriptions. This baseline data will be used in the future to assess the impact of electronic prescribing (EP) on prescribing error or intervention rates.Independently from the EP project research, I interrogated the data to establish if there was a correlation between prescribing workload and rate of errors or interventions. I predicted that an 'overworked' prescriber would make more mistakes due to the volume of the workload and a less frequent prescriber would make more mistakes due to scarce use of these skills...
September 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27540199/assessing-the-impact-of-a-newly-introduced-electronic-prescribing-system-across-a-paediatric-department-lessons-learned
#10
Anastasia Tsyben, Nigel Gooding, Wilf Kelsall
AIM: Prescribing audits have shown that the Women's and Children's Directorate reported higher number of prescription errors on the paediatric and neonatal wards compared to other areas in the Trust. Over the last three years a multidisciplinary prescribing team (PT), which included senior clinicians, pharmacists and trainees introduced a number of initiatives to improve the quality of prescribing. Strategies included structured departmental inductions, setting up of designated prescribing areas and reviewing errors with the prescriber...
September 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27528626/novel-ketone-diet-enhances-physical-and-cognitive-performance
#11
Andrew J Murray, Nicholas S Knight, Mark A Cole, Lowri E Cochlin, Emma Carter, Kirill Tchabanenko, Tica Pichulik, Melanie K Gulston, Helen J Atherton, Marie A Schroeder, Robert M J Deacon, Yoshihiro Kashiwaya, M Todd King, Robert Pawlosky, J Nicholas P Rawlins, Damian J Tyler, Julian L Griffin, Jeremy Robertson, Richard L Veech, Kieran Clarke
Ketone bodies are the most energy-efficient fuel and yield more ATP per mole of substrate than pyruvate and increase the free energy released from ATP hydrolysis. Elevation of circulating ketones via high-fat, low-carbohydrate diets has been used for the treatment of drug-refractory epilepsy and for neurodegenerative diseases, such as Parkinson's disease. Ketones may also be beneficial for muscle and brain in times of stress, such as endurance exercise. The challenge has been to raise circulating ketone levels by using a palatable diet without altering lipid levels...
December 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27520885/understanding-opioid-overdose-characteristics-involving-prescription-and-illicit-opioids-a-mixed-methods-analysis
#12
Bobbi Jo H Yarborough, Scott P Stumbo, Shannon L Janoff, Micah T Yarborough, Dennis McCarty, Howard D Chilcoat, Paul M Coplan, Carla A Green
BACKGROUND: Opioid abuse and misuse are significant public health issues. The CDC estimated 72% of pharmaceutical-related overdose deaths in the US in 2012 involved opioids. While studies of opioid overdoses have identified sociodemographic characteristics, agents used, administration routes, and medication sources associated with overdoses, we know less about the context and life circumstances of the people who experience these events. METHODS: We analyzed interviews (n=87) with survivors of opioid overdoses or family members of decedents...
October 1, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27513756/ingenol-mebutate-500-%C3%A2%C2%B5g-on-the-cheekbones-with-concomitant-conjunctivitis
#13
Olivier Gaide, Vincent Cattin
Ingenol mebutate induces strong inflammation after a single application already. This must be taken into account when prescribing the drug, as mistakes in the application may results in severe side effects. Here, we report the case of a 72-year-old woman who applied ingenol mebutate on the cheekbones and developed a pronounced conjunctivitis, needing topical corticosteroids. The treatment was intended for the actinic keratosis she had on the chest, and the regimen of 2 consecutive once daily applications of ingenol mebutate at 500 µg/g had been prescribed as registered...
2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27491172/-early-achievements-of-the-danish-pharmaceutical-industry-8-lundbeck
#14
Jørgen V Grevsen, Hanne Kirkegaard, Edith Kruse, Poul R Kruse
The article series provides a written and pictorial account of the Danish pharmaceutical industry's products from their introduction until about 1950. Part 8 deals with products from Lundbeck. Lundbeck which today is known as a considerable international pharmaceutical company could in 2015 celebrate its 100 years' jubilee. Among the early Danish medicinal companies H. Lundbeck & Co. is in many ways an exception as the company was not originally established as a pharmaceutical company. Not until several years after the foundation the company began to import foreign ready-made medicinal products and later-on to manufacture these medicinal products in own factory and even later to do research and development of own innovative products...
2016: Theriaca
https://www.readbyqxmd.com/read/27460631/developmental-exposure-to-paraquat-and-maneb-can-impair-cognition-learning-and-memory-in-sprague-dawley-rats
#15
Bai Li, Xi He, Yan Sun, Baixiang Li
Paraquat and maneb are identified environmental pollutants. Combined exposure to paraquat and maneb is a latent risk factor for many diseases, particularly those of the central nervous system, including Parkinson's disease and Alzheimer's disease. Hippocampus is the key structure in memory formation and babies are more sensitive to environmental stimuli than adults, so we investigated the neurotoxicity of paraquat and maneb on the hippocampi of rat pups. Female and male Sprague-Dawley rats were mated (female : male = 2 : 1) every night for a week...
October 20, 2016: Molecular BioSystems
https://www.readbyqxmd.com/read/27364171/development-of-software-for-handling-ship-s-pharmacy
#16
Giulio Nittari, Alessandro Peretti, Fabio Sibilio, Nicholas Ioannidis, Francesco Amenta
BACKGROUND: Ships are required to carry a given amount of medicinal products and medications depending on the flag and the type of vessel. These medicines are stored in the so called ship's "medicine chest" or more properly - a ship pharmacy. Owing to the progress of medical sciences and to the increase in the mean age of seafarers employed on board ships, the number of pharmaceutical products and medical devices required by regulations to be carried on board ships is increasing. This may make handling of the ship's medicine chest a problem primarily on large ships sailing on intercontinental routes due to the difficulty in identifying the correspondence between medicines obtained abroad with those available at the national market...
2016: International Maritime Health
https://www.readbyqxmd.com/read/27332296/improving-drugs-administration-safety-in-pediatric-resuscitation-using-mobile-technology
#17
Hamdi Hagberg, Johan Siebert, Alain Gervaix, Peter Daehne, Christian Lovis, Sergio Manzano, Frederic Ehrler
The fast preparation of drugs during pediatric resuscitation is of utmost importance. The influence of the patient's weight on the drug doses requires to perform complex calculations and is a source of errors. A technological solution could be a real help in avoiding these kinds of mistakes. Relying on a user centered approach we have developed an application supporting drug preparation. It has been tested in simulations with predefined scenario. The developed tool consists of a screen displaying a list of drug that can be administered...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27274794/predisposing-factors-for-methadone-poisoning-in-children-hospitalized-at-kerman-afzalipour-hospital-iran
#18
Ali Hosseininasab, Aliasghar Vahidi, Fatemeh Bagheri-Charouk
BACKGROUND: Methadone is a synthetic opioid that has been used to relieve severe pain in addiction withdrawal. Unfortunately, due to non-standard supply and storage, the incidence of poisoning and deaths caused by this drug is increasing daily. The purpose of this study was to determine the underlying causes of methadone poisoning in children admitted to Kerman Afzalipour Hospital, Kerman University of Medical Sciences, Iran, during 2012. METHODS: This cross-sectional study was performed on 105 children diagnosed with methadone poisoning and admitted to the pediatric emergency ward at Kerman Afzalipour Hospital...
2016: Addiction & Health
https://www.readbyqxmd.com/read/27271696/tyrosinemia-type-i-and-not-treatment-with-ntbc-causes-slower-learning-and-altered-behavior-in-mice
#19
Megan A Hillgartner, Sarah B Coker, Ashton E Koenig, Marissa E Moore, Elizabeth Barnby, Gordon G MacGregor
Tyrosinemia type I is a recessive inborn error of metabolism caused by mutations in the fumarylacetoacetate hydrolase (FAH) gene, coding for the final enzyme in the metabolism of tyrosine. This renders FAH nonfunctional and without treatment, toxic metabolites accumulate causing liver and kidney damage. Introduction of the drug NTBC in 2002 offered a treatment which inhibits an upstream enzyme, preventing the production of the toxic metabolites. There is now a long-term survival rate of greater than 90 % in children, but there are reports of lower cognitive function and IQ as well as schooling and behavioral problems in these children...
September 2016: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/27252767/iranian-version-of-manchester-driving-behavior-questionnaire-mdbq-psychometric-%C3%A2-properties
#20
Seyyed Salman Alavi, Mohammadreza Mohammadi, Hamid Soori, Soroush Mohammadi Kalhori, Neda Sepasi, Rasoul Khodakarami, Mojtaba Farshchi, Niloofar Hasibi, Soodabeh Rostami, Hadis Razi, Mohammad Babareisi
OBJECTIVE: Since the study of driving behavior is of great importance, we conducted this research to ‎investigate the psychometric properties and the factorial structure of the Manchester Driver ‎Behavior Questionnaire (DBQ) in Iranian drivers.‎ METHOD: This cross - sectional research was performed on a sample of 800 drivers (of category D and ‎C) aged 23- 75 who were referred to Imam Sajjad Centre for drug Addiction Diagnosis. ‎Manchester Driver Behavior Questionnaire (DBQ), a demographic questionnaire, were ‎conducted to the sample...
January 2016: Iranian Journal of Psychiatry
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