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https://www.readbyqxmd.com/read/28544857/new-treatment-directions-for-ipf-current-status-of-ongoing-and-upcoming-clinical-trials
#1
Francesco Macagno, Francesco Varone, Paolo Maria Leone, Pier-Valerio Mari, Loredana Panico, Ludovica Berardini, Luca Richeldi
The main objective of this review is to explore the wide and expanding field of new clinical trials in IPF. Recent trials have confirmed the efficacy of the approved drugs pirfenidone and nintedanib; nonetheless, the discovery of new biological pathways has opened new horizons in this field. Areas Covered: New strategies against matrix deposition are under study and so is for the role of immunity and autoimmunity. Recent advances in the use of stem cells are opening new possibilities for the recovery of damaged lung tissues...
May 25, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28523298/role-of-genetic-polymorphism-in-nutritional-supplementation-therapy-in-personalized-medicine
#2
Nicolae Ovidiu Peneş, Bernard Weber, Silviu Dumitru Păun
Genetic-guided nutritional supplementation therapy in personalized medicine is the type of treatment that prevents and acts against errors during the copying process of a cell's deoxyribonucleic acid (DNA), mistakes that lead to diversification in the DNA sequence at certain locations, called single nucleotide polymorphisms (SNPs). Positive results are quickly achieved using one of the four types of therapy. These types are: personalized, when individual human genetic variations drive individual treatment, preventive, with a tailored healthcare strategy and therapeutic preventive drugs and vaccines, participatory, when empowered patients make informed choices and take responsibility of their own health and predictive, using a proactive approach to health and medicine...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28504508/-mistakes-in-drug-prescription-during-simulated-pediatric-resuscitations-and-other-urgency-procedures
#3
Diego Enriquez, Raúl Gómez Traverso, Silvina Brizuela, Edgardo Szyld
INTRODUCTION: The probability of making mistakes in the prescription of medicines is high in pediatrics, and substantially increases in emergency situations. MATERIAL AND METHODS: This prospective observational study analyzed the prescriptions issued by physicians during 23 cardiopulmonary resuscitation pediatric emergency training sessions. RESULTS: During 94 simulated cases, 96 physicians participated. Forty-four prescriptions on paper were analyzed (48%) including 120 doses...
June 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28393967/-errors-in-prescriptions-and-their-preparation-at-the-outpatient-pharmacy-of-a-regional-hospital
#4
Carolina Alvarado A, Ximena Ossa G, Luis Bustos M
BACKGROUND: Adverse effects of medications are an important cause of morbidity and hospital admissions. Errors in prescription or preparation of medications by pharmacy personnel are a factor that may influence these occurrence of the adverse effects Aim: To assess the frequency and type of errors in prescriptions and in their preparation at the pharmacy unit of a regional public hospital. MATERIAL AND METHODS: Prescriptions received by ambulatory patients and those being discharged from the hospital, were reviewed using a 12-item checklist...
January 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28357835/identification-of-world-health-organisation-ship-s-medicine-chest-contents-by-anatomical-therapeutic-chemical-atc-classification-codes
#5
Seyed Khorsow Tayebati, Giulio Nittari, Syed Sarosh Mahdi, Nicholas Ioannidis, Fabio Sibilio, Francesco Amenta
BACKGROUND: Ships should carry mandatory given amounts of medicinal products and basic first aid items, collectively known as the ship's medicine chest. Type and quantities of these products/items are suggested by the World Health Organisation (WHO) and regulated by individual flag states. In countries that lack national legislation, it is assumed that ships should follow WHO indications. An objective difficulty mainly involving vessels of international long-haul routes could be to recognise medicinal compounds obtained in other countries for replacing products used or expired...
2017: International Maritime Health
https://www.readbyqxmd.com/read/28352924/-abomasal-ulcers-in-cattle
#6
Alexandra Hund, Thomas Wittek
Abomasal ulcers lead to several problems. They cause pain resulting in a decrease in productivity and even the possible loss of the animal. Because they are frequently difficult to diagnose, information on their prevalence is variable. Additionally, therapeutic options are limited. Abomasal ulcers are graded as type 1 through 4, type 1 being a superficial defect and type 2 an ulcer where a large blood vessel has been eroded, leading to substantial blood loss. Types 3 and 4 are perforated abomasal ulcers leading to local and diffuse peritonitis, respectively...
March 29, 2017: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/28284323/optimizing-drug-delivery-in-copd-the-role-of-inhaler-devices
#7
REVIEW
Paola Rogliani, Luigino Calzetta, Angelo Coppola, Francesco Cavalli, Josuel Ora, Ermanno Puxeddu, Maria Gabriella Matera, Mario Cazzola
Inhaled medication is the cornerstone of the pharmacological treatment for patients with asthma and chronic obstructive pulmonary disease (COPD). Several inhaler devices exist, and each device has specific characteristics to achieve the optimal inhalation of drugs. The correct use of inhaler devices is not granted and patients may incur in mistakes when using pressurized metered-dose inhalers (pMDIs) or dry-powder inhaler (DPIs). The incorrect use of inhaler devices can lead to a poorly controlled disease status...
March 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28244963/consideration-of-muscle-depth-for-botulinum-toxin-injections-a-three-dimensional-approach
#8
Julie Bass Kaplan
Knowledge of variable anatomy is key for excellent outcomes from the administration of botulinum toxin for aesthetic purposes. One must understand the location and function of each facial muscle to predict the patient's desired outcome. One concept often overlooked by injectors is the understanding of the target muscle's depth. In addition, a firm understanding of where each facial muscle originates and attaches can be essential to correctly identifying and injecting the correct muscle with botulinum toxin...
January 2017: Plastic Surgical Nursing
https://www.readbyqxmd.com/read/28236867/medication-errors-in-anesthesia-unacceptable-or-unavoidable
#9
Ira Dhawan, Anurag Tewari, Sankalp Sehgal, Ashish Chandra Sinha
Medication errors are the common causes of patient morbidity and mortality. It adds financial burden to the institution as well. Though the impact varies from no harm to serious adverse effects including death, it needs attention on priority basis since medication errors' are preventable. In today's world where people are aware and medical claims are on the hike, it is of utmost priority that we curb this issue. Individual effort to decrease medication error alone might not be successful until a change in the existing protocols and system is incorporated...
March 2017: Brazilian Journal of Anesthesiology
https://www.readbyqxmd.com/read/28222477/checklists-for-the-assessment-of-correct-inhalation-therapy
#10
V Knipel, S Schwarz, F S Magnet, J H Storre, C P Criée, W Windisch
Introduction For the long-term treatment of obstructive lung diseases inhalation therapy with drugs being delivered directly to the lungs as an aerosol has become the method of choice. However, patient-related mistakes in inhalation techniques are frequent and recognized to be associated with reduced disease control. Since the assessment of patient-mistakes in inhalation has yet not been standardized, the present study was aimed at developing checklists for the assessment of correct inhalation. Methods Checklists were developed in German by an expert panel of pneumologists and professionally translated into English following back-translation procedures...
February 2017: Pneumologie
https://www.readbyqxmd.com/read/28208750/the-consequences-of-chromosome-segregation-errors-in-mitosis-and-meiosis
#11
REVIEW
Tamara Potapova, Gary J Gorbsky
Mistakes during cell division frequently generate changes in chromosome content, producing aneuploid or polyploid progeny cells. Polyploid cells may then undergo abnormal division to generate aneuploid cells. Chromosome segregation errors may also involve fragments of whole chromosomes. A major consequence of segregation defects is change in the relative dosage of products from genes located on the missegregated chromosomes. Abnormal expression of transcriptional regulators can also impact genes on the properly segregated chromosomes...
February 8, 2017: Biology
https://www.readbyqxmd.com/read/28130544/mistaking-2c-p-for-2c-b-what-a-difference-a-letter-makes
#12
Adrian Stoller, Patrick C Dolder, Michael Bodmer, Felix Hammann, Katharina M Rentsch, Aristomenis K Exadaktylos, Matthias E Liechti, Evangelia Liakoni
2,5-Dimethoxy-4(n)-propylphenethylamine (2C-P) is a synthetic phenethylamine derivative belonging to the large family of the so-called 2C drugs. These compounds can differ significantly in receptor affinity, potency and duration of action, and an important structural difference is the ligand in the 4 position of the phenyl ring, such as propyl in 2C-P or bromine in 2,5-dimethoxy-4-bromophenethylamine (2C-B). The 2C drugs are known for their hallucinogenic properties. We present a case of a 19-year-old male admitted to the emergency department with severe hallucinations, mydriasis, tachycardia, agitation and confusion following the use of a substance sold as 2C-B...
January 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28038759/-medication-errors-in-anesthesia-unacceptable-or-unavoidable
#13
Ira Dhawan, Anurag Tewari, Sankalp Sehgal, Ashish Chandra Sinha
Medication errors are the common causes of patient morbidity and mortality. It adds financial burden to the institution as well. Though the impact varies from no harm to serious adverse effects including death, it needs attention on priority basis since medication errors' are preventable. In today's world where people are aware and medical claims are on the hike, it is of utmost priority that we curb this issue. Individual effort to decrease medication error alone might not be successful until a change in the existing protocols and system is incorporated...
March 2017: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/27939873/letter-to-the-editor-on-the-necessity-of-overhaul-in-perception-of-microbiological-culture-methods
#14
LETTER
Seema Patel
Unarguably, clinical microbiology has got a boost from NGS technology, but in the process of this transition it has suffered a huge setback. Computational biology can find the microbial genomic variations and can link it to drug resistance, but it has so far underestimated the crucial role of microbial culture medium. The constituents and growth conditions of the medium have been documented to shuffle genomic, epigenetic and metabolic aspects of the bacterial pathogens. Ignoring these in vitro-driven evolutions and attributing the variations as normal bacterial features, responsible for drug resistance is a huge mistake...
January 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27921426/-gestational-diabetes-mellitus
#15
Hana Krejčí
The present generation of women of childbearing age more frequently suffer from overweight, obesity, initial as well as fully established metabolic syndrome, which together with postponing motherhood until the third decade in life plays an important role in the increasing incidence of gestational diabetes (GDM) that currently affects about 1/5 of pregnant women. However the causal link between diabetes during pregnancy and metabolic diseases in the whole population is mutual. By way of epigenetic changes, maternal diabetes unfavourably programmes metabolism of the offspring, who tend to transfer the disorder to the next generations...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27819782/-dynamic-long-term-and-institutional-psychotherapy-to-treat-persistent-depressive-disorders
#16
Jorge Garibay
BACKGROUND: Major depression is a public health problem that threatens to become the second leading cause of disability in the world. In this study we show the results obtained once we applied a psychodynamic psychotherapeutic and long-term process in patients with major depressive disorder, attending a public health institution (PHI). METHODS: From a list of female volunteers, we randomly selected 30 patients who met the diagnostic criteria of major depression...
November 2016: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/27757060/omics-approaches-to-individual-variation-modeling-networks-and-the-virtual-patient
#17
Hans Lehrach
Every human is unique. We differ in our genomes, environment, behavior, disease history, and past and current medical treatment-a complex catalog of differences that often leads to variations in the way each of us responds to a particular therapy. We argue here that true personalization of drug therapies will rely on "virtual patient" models based on a detailed characterization of the individual patient by molecular, imaging, and sensor techniques. The models will be based, wherever possible, on the molecular mechanisms of disease processes and drug action but can also expand to hybrid models including statistics/machine learning/artificial intelligence-based elements trained on available data to address therapeutic areas or therapies for which insufficient information on mechanisms is available...
September 2016: Dialogues in Clinical Neuroscience
https://www.readbyqxmd.com/read/27737012/satisfaction-in-older-persons-and-general-practitioners-during-the-implementation-of-integrated-care
#18
Antonius J Poot, Monique A A Caljouw, Claudia S de Waard, Annet W Wind, Jacobijn Gussekloo
BACKGROUND: Integrated care for older persons with complex care needs is widely advocated. Particularly professionals and policy makers have positive expectations. Care outcome results are ambiguous. Receiver and provider satisfaction is relevant but still poorly understood. METHODS: During implementation of integrated care in residential homes (The MOVIT project), we compared general satisfaction and satisfaction with specific aspects of General Practitioner (GP) care in older persons and GPs before (cohort I) and after at least 12 months of implementation (cohort II)...
2016: PloS One
https://www.readbyqxmd.com/read/27716124/safer-drug-use-in-primary-care-a-pilot-intervention-study-to-identify-improvement-needs-and-make-agreements-for-change-in-five-swedish-primary-care-units
#19
Sara Modig, Cecilia Lenander, Nina Viberg, Patrik Midlöv
BACKGROUND: There is an urgent need to improve patient safety in the area of medication treatment among the elderly. The aim of this study was to explore which improvement needs and strengths, relating to medication safety, arise from a multi-professional intervention in primary care and further to describe and follow up on the agreements for change that were established within the intervention. METHODS: The SÄKLÄK project was a multi-professional intervention in primary care consisting of self-assessment, peer-review, feedback and written agreements for change...
October 4, 2016: BMC Family Practice
https://www.readbyqxmd.com/read/27611098/authentication-of-schisandra-chinensis-and-schisandra-sphenanthera-in-chinese-patent-medicines
#20
Pin Jiang, Yan Lu, Daofeng Chen
Authentication of species is crucial for ensuring the safety and efficacy of herbal medicines. The fruits of Schisandra chinensis and S. sphenanthera have been used for the same traditional Chinese drug, Wuweizi, but are found to be quite different according to their constituents, pharmacological effects, and qualities. These two fruits have been recorded as Schisandrae Chinensis Fructus (Wuweizi) and Schisandrae Sphenantherae Fructus (Nan-wuweizi), respectively, by Chinese Pharmacopoeia, 2000 edition. However, Nan-wuweizi is often found to be taken as Wuweizi in some Chinese patent drugs intentionally or by mistake because of its lower price and similar characteristics to Wuweizi...
November 30, 2016: Journal of Pharmaceutical and Biomedical Analysis
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