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https://www.readbyqxmd.com/read/29303355/nitroimidazoles-as-hypoxic-cell-radiosensitizers-and-hypoxia-probes-misonidazole-myths-and-mistakes
#1
Peter Wardman
Nitroimidazoles have been extensively explored as hypoxic cell radiosensitizers but have had limited clinical success, with efficacy restricted by toxicity. However, they have proven clinically useful as probes for tumour hypoxia. Both applications, and probably much of the dose-limiting toxicities, reflect the dominant chemical property of electron affinity or ease of reduction, associated with the nitro substituent in an aromatic structure. This single dominant property affords unusual, indeed extraordinary flexibility in drug or probe design, suggesting further development is possible in spite of earlier limitations, in particular building on the benefit of hindsight and an appreciation of errors made in earlier studies...
January 5, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29295971/special-k-with-no-license-to-kill-accidental-ketamine-overdose-on-induction-of-general-anesthesia
#2
Lindsay L Warner, Nathan Smischney
BACKGROUND Ketamine is used as an induction and sedation agent in emergency departments and operating rooms throughout the country. Despite its widespread clinical use, there are few cases of significant morbidity and mortality attributed to ketamine overdose in the clinical setting. CASE REPORT The anesthesia provider in the room was an oral maxillofacial surgeon who inadvertently took out a more highly concentrated bottle of ketamine that is typically used for pediatric patients. The patient received 950 mg (100 mg/ml concentration) of intravenous ketamine instead of the intended 95 mg (10 mg/ml concentration)...
January 3, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29237326/a-chamber-of-errors-adaptation-to-assess-pharmaceutical-assistants-knowledge-in-chemotherapy-preparation
#3
C Loboda, J Vigneron, C Mulot, I May, B Demore
French preparation guidelines state that pharmacy staff who manipulate cytotoxic drugs have to follow specific training. In order to assess the pharmaceutical assistants' skills and knowledge, we developed a "Cytotoxic Preparation Centralized Unit (CPCU) of errors," derived from the Canadian concept of "Chamber of horrors." A table listing 20 mistakes to track down was created and each pharmaceutical assistant spent 20 min in the "CPCU of errors" with the pharmacist, who wrote down the spotted mistakes in real time...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29204766/correction-to-informing-materials-drugs-as-tools-for-exploring-cancer-mechanisms-and-pathways
#4
Etienne Vignola-Gagné, Peter Keating, Alberto Cambrosio
The original version of this article unfortunately contained a mistake. Three entries are incorrect in the reference list. The corrected references are given below.
December 4, 2017: History and Philosophy of the Life Sciences
https://www.readbyqxmd.com/read/29166038/theory-of-polyelectrolyte-complexation-complex-coacervates-are-self-coacervates
#5
Kris T Delaney, Glenn H Fredrickson
The complexation of mixtures of cationic and anionic polymers to produce complex-coacervate phases is a subject of fundamental importance to colloid and polymer science as well as to applications including drug delivery, sensing technologies, and bio-inspired adhesives. Unfortunately the theoretical underpinnings of complex coacervation are widely misunderstood and conceptual mistakes have propagated in the literature. Here, a simple symmetric polyelectrolyte mixture model in the absence of salt is used to discuss the salient features of the phase diagram, including the location of the critical point, binodals, and spinodals...
June 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29162776/erratum-for-sushi-repeat-containing-protein-x-linked-2-promotes-angiogenesis-through-the-urokinase-type-plasminogen-activator-receptor-dependent-integrin-%C3%AE-v%C3%AE-3-focal-adhesion-kinase-pathways-by-liu-kl-et-al-drug-discov-ther-2017-11-4-212-217
#6
(no author information available yet)
In the article entitled "Sushi repeat-containing protein X-linked 2 promotes angiogenesis through the urokinase-type plasminogen activator receptor dependent integrin αvβ3/focal adhesion kinase pathways" by Liu KL et al. (Drug Discov Ther. 2017; 11(4):212-217.), a mistake in Figure 3a (αvβ3) has been identified. Figure 3 is printed below.
2017: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/29141983/are-parents-who-feel-the-need-to-watch-over-their-children-s-care-better-patient-safety-partners
#7
Elizabeth D Cox, Kristofer Hansen, Victoria P Rajamanickam, Roger L Brown, Paul J Rathouz, Pascale Carayon, Lori L DuBenske, Linda A Buel, Michelle M Kelly
OBJECTIVES: Many parents report needing to watch over their child's hospital care to prevent mistakes. In this study, we assessed whether needing to watch over care predicts parent performance of recommended safety behaviors to reduce medication errors and health care-associated infections. METHODS: At admission, we surveyed 170 parents about their need to watch over care, demographics, and hospitalization factors. At discharge, parents were surveyed about medication awareness and hand hygiene behaviors...
November 15, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/29140767/genomic-medicine-without-borders-which-strategies-should-developing-countries-employ-to-invest-in-precision-medicine-a-new-fast-second-winner-strategy
#8
Konstantinos Mitropoulos, David N Cooper, Christina Mitropoulou, Spiros Agathos, Jürgen K V Reichardt, Fatima Al-Maskari, Wasun Chantratita, Ambroise Wonkam, Collet Dandara, Theodora Katsila, Catalina Lopez-Correa, Bassam R Ali, George P Patrinos
Genomic medicine has greatly matured in terms of its technical capabilities, but the diffusion of genomic innovations worldwide faces significant barriers beyond mere access to technology. New global development strategies are sorely needed for biotechnologies such as genomics and their applications toward precision medicine without borders. Moreover, diffusion of genomic medicine globally cannot adhere to a "one-size-fits-all-countries" development strategy, in the same way that drug treatments should be customized...
November 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29115074/adapter-based-safety-injection-system-for-prevention-of-wrong-route-and-wrong-patient-medication-errors
#9
Yong Chan Cho, Seung Ho Lee, Yang Hyun Cho, Young Bin Choy
Wrong-route or -patient medication errors due to human mistakes have been considered difficult to resolve in clinical settings. In this study, we suggest a safety injection system that can help to prevent an injection when a mismatch exists between the drug and route or patient. For this, we prepared two distinct adapters with key and keyhole patterns specifically assigned to a pair of drug and route or patient. When connected to a syringe tip and its counterpart, a catheter injection-port, respectively, the adapters allowed for a seamless connection only with their matching patterns...
December 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29099732/error-in-drugs-consumption-among-older-patients
#10
Yosefa Bar-Dayan, Thomas Shotashvily, Mona Boaz, Julio Wainstein
The cost effectiveness of generic drugs has promoted their use worldwide. However, the large variety of bioequivalent generic and brand-name drugs found in the marketplace increases the complexity and frequency of mistakes in drug consumption. This clinical study investigated the prevalence of various mistakes in drug consumption by patients using a hospital setting. This prospective clinical trial used a hospital setting to identify errors in drug consumption. Six hundred patients who were hospitalized for a minimum of 48 hours in the Internal Medicine Departments were checked at various time points...
November 2017: American Journal of Therapeutics
https://www.readbyqxmd.com/read/29064337/david-bowie-and-the-art-of-slow-innovation-a-fast-second-winner-strategy-for-biotechnology-and-precision-medicine-global-development
#11
Vural Özdemir, George P Patrinos
Original ideas and innovation cannot always be ordered like a courier service and delivered fresh to our desk at 9 am. Yet, most creativity-based organizations, careers, and professions, science and biotechnology innovation included, emphasize the speed as the prevailing ideology. But a narrow focus on speed has several and overlooked shortcomings. For example, it does not offer the opportunity to draw from, and stitch together disparate concepts and practices for truly disruptive innovation. Preventing false starts, learning from others' or our own mistakes, and customizing innovations for local community needs are difficult in a speed-hungry innovation ecosystem...
November 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29049121/opioids-for-the-treatment-of-chronic-pain-mistakes-made-lessons-learned-and-future-directions
#12
REVIEW
Jane C Ballantyne
An overreliance on opioids has impacted all types of pain management, making it undoubtedly a root cause of the "epidemic" of prescription opioid abuse in the United States. Yet, an examination of the statistics that led the US Centers for Disease Control and Prevention to declare that prescription opioid abuse had reached epidemic levels shows that the abuse occurrences and deaths are arising outside the hospital or hospice setting, which strongly implicates the outpatient use of opioids to treat chronic pain...
November 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28966240/survey-on-the-original-plant-species-of-crude-drugs-distributed-as-cynanchi-wilfordii-radix-and-its-related-crude-drugs-in-the-korean-and-chinese-markets
#13
Naoko Sato-Masumoto, Takashi Uchikura, Hidemi Sugiwaki, Morio Yoshimura, Sayaka Masada, Toshiyuki Atsumi, Masato Watanabe, Nobuyuki Tanaka, Nahoko Uchiyama, Yoshiaki Amakura, Takashi Hakamatsuka
Cynanchi Wilfordii Radix (CWR) is used in Korea as a substitute for Polygoni Multiflori Radix (PMR), which is a crude drug traditionally used in East Asian countries. Recently, the use of Cynanchi Auriculati Radix (CAR) in place of PMR and CWR has emerged a major concern in the Korean market. In Japan, PMR is permitted to be distributed as a pharmaceutical regulated by the Japanese Pharmacopoeia 17th edition (JP17). Although CWR and CAR have not traditionally been used as medicines, CWR was recently introduced as a health food...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28956300/chronic-disease-and-self-injection-ethnographic-investigations-into-the-patient-experience-during-treatment
#14
Michael Schiff, Shane Saunderson, Irina Mountian, Paul Hartley
INTRODUCTION: Drug administration by self-injection provides an option to treat chronic inflammatory diseases such as rheumatoid arthritis (RA) and Crohn's disease (CD). However, a negative self-injection experience for patients may reduce patient adherence to the recommended treatment regimen. In this study, a holistic approach was used to identify common themes along the treatment pathway and at self-injection that, if changed, could improve patient experience and treatment outcomes...
December 2017: Rheumatology and Therapy
https://www.readbyqxmd.com/read/28952016/the-impact-of-irreproducibility-and-competing-protection-from-p2y12-antagonists-on-the-discovery-of-cardioprotective-interventions
#15
REVIEW
Michael V Cohen, James M Downey
Scientists and clinicians have been concerned by the lack of a clinically suitable strategy for cardioprotection in patients with acute myocardial infarction despite decades of intensive pre-clinical investigations and a surprising number of clinical trials based on those observations which have uniformly been disappointing. However, it would be a mistake to abandon this search. Rather it would be useful to examine these past efforts and determine reasons for the multiple failures. It appears that earlier clinical trials were often based on results from a single experimental laboratory, thus minimizing the importance of establishing reproducibility in multiple laboratories by multiple scientists and in multiple models...
September 26, 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/28927896/niacin-and-heart-disease-prevention-engraving-its-tombstone-is-a-mistake
#16
REVIEW
Harold Robert Superko, Xue-Qiao Zhao, Howard N Hodis, John R Guyton
Niacin (nicotinic acid) has been used for primary and secondary coronary heart disease prevention for over 40 years. Until recently clinical trials incorporating niacin as part of an intervention strategy consistently demonstrated reduction in clinical events and lesion improvement, including ≥6% absolute mortality reduction. Two large clinical event trials in 2011 (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides and Impact on Global Health Outcomes) and 2014 (Heart Protection Study 2-Treatment of HDL to Reduce the Incidence of Vascular Events) concluded that niacin added to statin therapy did not provide clinical event benefit over statin alone...
November 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28904727/post-ivermectin-encephalopathy-in-senegal-a-case-report
#17
Daniel Gams Massi, Mohamed Lelouma Mansare, Mariétou Traoré, Moustapha Ndiaye, Amadou Gallo Diop, Mouhamadou Mansour Ndiaye
Ivermectin is an ant parasitic drug used for combating onchocerciasis and lymphatic filariasis. It works by inhibiting the function of neurons and muscles, thus causing paralysis of microfilariae. Side effects of this drug have been reported including post-ivermectin encephalopathy requiring emergency care in hospital. We report the case of a 35 years old patient living in rural areas of Senegal who presented two days after a mistake in administration of a second dose of ivermectin, headaches, altered consciousness and bilateral blindness...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28900073/-molecular-mechanisms-of-hiv-1-genetic-diversity
#18
D V Sosin, N A Tchurikov
High genetic diversity of HIV-1 is the main factor behind the fact that HIV infection is widespread and difficult to treat. Although a limited number (or only one) of virus particles enters the blood upon infection, the particles are replicated in infected cells and rapidly produce new genetic variants that are resistant to the host immune system and antiretroviral drugs. This circumstance hampers the development of anti-HIV-1 vaccines and requires new antiretroviral drugs to be designed. The cause of the high variation of HIV-1 is related to the properties of its reverse transcriptase, which is error prone and often makes mistakes when transcribing virus RNA...
July 2017: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/28893010/evaluation-of-the-potency-of-kinetin-on-radiation-induced-behavioural-changes-in-swiss-albino-mice
#19
Vishakh Radhakrishna, Suchetha Kumari Nanilu, Ganesh Sanjeev, Jayarama Shetty, Yogish Tenkanidiyoor Somyaji, Shailaja Shivarama Moodithaya
INTRODUCTION: According to the various independent studies conducted, it is well evident fact that radiation induces oxidative stress in the living system. It is also proved that this oxidative stress will lead to the various behavioural changes such as anxiety and memory impairment. Kinetin is one of the important plant cytokine with anti-aging properties. However, very few studies were conducted to check its potential in ameliorating the behavioural changes induced by the ionizing radiation...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28878928/evaluation-of-a-guided-continuous-quality-improvement-program-in-community-pharmacies
#20
Chanadda Chinthammit, Michael T Rupp, Edward P Armstrong, Tara Modisett, Rebecca P Snead, Terri L Warholak
BACKGROUND: The importance of creating and sustaining a strong culture of patient safety has been recognized as a critical component of safe medication use. This study aims to assess changes in attitudes toward patient safety culture and frequency of quality-related event (QRE) reporting after guided implementation of a continuous quality improvement (CQI) program in a panel of community pharmacies in the United States (U.S.). METHODS: Twenty-one community pharmacies volunteered to participate in the project and were randomly assigned to intervention or control groups...
2017: Journal of Pharmaceutical Policy and Practice
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