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Drug error

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https://www.readbyqxmd.com/read/29457585/training-nurses-in-a-competency-framework-to-support-adults-with-epilepsy-and-intellectual-disability-the-epaid-cluster-rct
#1
Howard Ring, James Howlett, Mark Pennington, Christopher Smith, Marcus Redley, Caroline Murphy, Roxanne Hook, Adam Platt, Nakita Gilbert, Elizabeth Jones, Joanna Kelly, Angela Pullen, Adrian Mander, Cam Donaldson, Simon Rowe, James Wason, Fiona Irvine
BACKGROUND: People with an intellectual (learning) disability (ID) and epilepsy have an increased seizure frequency, higher frequencies of multiple antiepileptic drug (AED) use and side effects, higher treatment costs, higher mortality rates and more behavioural problems than the rest of the population with epilepsy. The introduction of nurse-led care may lead to improvements in outcome for those with an ID and epilepsy; however, this has not been tested in a definitive clinical trial...
February 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29457309/severe-intestinal-malabsorption-associated-with-ace-inhibitor-or-angiotensin-receptor-blocker-treatment-an-observational-cohort-study-in-germany-and-italy
#2
Peter Malfertheiner, Claudio Ripellino, Nazarena Cataldo
PURPOSE: The angiotensin II receptor blocker (ARB) olmesartan has been recently associated with sprue-like enteropathy (SLE), a gastrointestinal condition characterized by intestinal malabsorption (IM) and severe diarrhea. Whether the increased risk of SLE is substance-specific or a class effect involving all ARBs is uncertain. The aim of this study is to assess the risk of enteropathy associated with ARBs and angiotensin converting enzyme inhibitors (ACE-i) by using data from large administrative and claim databases...
February 19, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29454529/retention-prediction-in-reversed-phase-high-performance-liquid-chromatography-using-quantitative-structure-retention-relationships-applied-to-the-hydrophobic-subtraction-model
#3
Yabin Wen, Mohammad Talebi, Ruth I J Amos, Roman Szucs, John W Dolan, Christopher A Pohl, Paul R Haddad
Quantitative Structure-Retention Relationships (QSRR) methodology combined with the Hydrophobic Subtraction Model (HSM) have been utilized to accurately predict retention times for a selection of analytes on several different reversed phase liquid chromatography (RPLC) columns. This approach is designed to facilitate early prediction of co-elution of analytes, for example in pharmaceutical drug discovery applications where it is advantageous to predict whether impurities might be co-eluted with the active drug component...
February 8, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29452813/incidence-characteristics-and-predictive-factors-for-medication-errors-in-paediatric-anaesthesia-a-prospective-incident-monitoring-study
#4
C Gariel, B Cogniat, F-P Desgranges, D Chassard, L Bouvet
BACKGROUND: Medication errors are not uncommon in hospitalized patients. Paediatric patients may have increased risk for medication errors related to complexity of weight-based dosing calculations or problems with drug preparation and dilution. This study aimed to determine the incidence of medication errors in paediatric anaesthesia in a university paediatric hospital, and to identify their characteristics and potential predictive factors. METHODS: This prospective incident monitoring study was conducted between November 2015 and January 2016 in an exclusively paediatric surgical centre...
March 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29451021/the-uva-padova-type-1-diabetes-simulator-goes-from-single-meal-to-single-day
#5
Roberto Visentin, Enrique Campos-Náñez, Michele Schiavon, Dayu Lv, Martina Vettoretti, Marc Breton, Boris P Kovatchev, Chiara Dalla Man, Claudio Cobelli
BACKGROUND: A new version of the UVA/Padova Type 1 Diabetes (T1D) Simulator is presented which provides a more realistic testing scenario. The upgrades to the previous simulator, which was accepted by the Food and Drug Administration in 2013, are described. METHOD: Intraday variability of insulin sensitivity (S I ) has been modeled, based on clinical T1D data, accounting for both intra- and intersubject variability of daily S I . Thus, time-varying distributions of both subject's basal insulin infusion and insulin-to-carbohydrate ratio were calculated and made available to the user...
February 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29448305/development-and-validation-of-gc-ms-ms-method-for-simultaneous-quantitation-of-several-antipsychotics-in-human-plasma-and-oral-fluid
#6
Tiago Rosado, David Oppolzer, Belinda Cruz, Mário Barroso, Samira Varela, Victor Oliveira, Carlos Leitão, Eugenia Gallardo
RATIONALE: Antipsychotic drugs are prescription medications used to treat psychotic disorders, such as schizophrenia, schizoaffective disorder, or psychotic depression. With several antipsychotic drugs currently available all over the world, this class of drugs has quickly gotten importance in both clinical and forensic context. This work describes the development and validation of a methodology for the determination of seven antipsychotic drugs in plasma and oral fluid samples. METHODS: The antipsychotic drugs (chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, cyamemazine and, levomepromazine) were isolated from 0...
February 15, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29445304/prevalence-of-medication-errors-in-primary-health-care-at-bahrain-defence-force-hospital-prescription-based-study
#7
Fatema Aljasmi, Fatema Almalood, Ahmed Al Ansari
Background: One of the important activities that physicians - particularly general practitioners - perform is prescribing. It occurs in most health care facilities and especially in primary health care (PHC) settings. Objectives: This study aims to determine what types of prescribing errors are made in PHC at Bahrain Defence Force (BDF) Hospital, and how common they are. Methods: This was a retrospective study of data from PHC at BDF Hospital...
2018: Drug, Healthcare and Patient Safety
https://www.readbyqxmd.com/read/29444120/computer-tomography-based-body-surface-area-evaluation-for-drug-dosage-quantitative-radiology-versus-anthropomorphic-evaluation
#8
Antoine Iannessi, Hubert Beaumont, Christophe Hebert, Claire Dittlot, Marie Noëlle Falewee
OBJECTIVE: The measure of body surface area (BSA) is a standard for planning optimal dosing in oncology. This index is derived from a model having questionable performances. In this study, we proposed measurement of BSA from whole body CT images (iBSA). We tested the reliability of iBSA assessments and simulated the impact of our approach on patient chemotherapy dosage planning. METHODS: We first evaluated accuracy and precision of iBSA in measuring 14 phantom and 11 CT test-retest images...
2018: PloS One
https://www.readbyqxmd.com/read/29442006/a-time-scaled-convolution-approach-to-construct-ivivc-for-enteric-coated-acetylsalicylic-acid-tablets
#9
J Al-Gousous, P Langguth
A scaled convolution-based in vitro-in vivo (IVIVC) model was constructed for two enteric-coated acetylsalicylic acid tablet formulations. The in vitro data used were the results of dissolution testing performed using three different dissolution methods: the United States Pharmacopoeia (USP) method, a method employing blank Fasted State Simulated Fluid (FaSSIF), and a new method developed in house. The in vivo data were obtained from a pharmacokinetic study on human subjects in the fasted state. When the new dissolution method results were used, an average prediction error less than 10% and a maximum prediction error less than 15% were obtained for the peak plasma concentration (Cmax) and area under the curve (AUC) parameters, thus meeting the internal validation criteria of the IVIVC guidance of the US Food and Drug Administration (FDA)...
February 1, 2018: Die Pharmazie
https://www.readbyqxmd.com/read/29440481/prospective-evaluation-of-medication-related-clinical-decision-support-over-rides-in-the-intensive-care-unit
#10
Adrian Wong, Mary G Amato, Diane L Seger, Christine Rehr, Adam Wright, Sarah P Slight, Patrick E Beeler, E John Orav, David W Bates
BACKGROUND: Clinical decision support (CDS) displayed in electronic health records has been found to reduce the incidence of medication errors and adverse drug events (ADE). Recent data suggested that medication-related CDS alerts were frequently over-ridden, often inappropriately. Patients in the intensive care unit (ICU) are at an increased risk of ADEs; however, limited data exist on the benefits of CDS in the ICU. This study aims to evaluate potential harm associated with medication-related CDS over-rides in the ICU...
February 9, 2018: BMJ Quality & Safety
https://www.readbyqxmd.com/read/29437211/an-observational-feasibility-study-of-a-new-anaesthesia-drug-storage-tray
#11
D S Almghairbi, L Sharp, R Griffiths, R Evley, S Gupta, I K Moppett
Drug errors in the anaesthetic domain remain a serious cause of iatrogenic harm. To help reduce this issue, we explored the potential safety impact of using a simple colour-coded tray for anaesthetic drug preparation and storage. Over a six-month period, three different trained researchers observed 30 cases at three NHS Trusts. Ten observations involved standard drug trays in 'normal' practice, and 20 observations, involved 'Rainbow trays' before and after their introduction. We conducted 20 semi-structured interviews immediately after completing the Rainbow tray observation with the anaesthetists involved...
March 2018: Anaesthesia
https://www.readbyqxmd.com/read/29435904/performance-of-the-population-bioequivalence-pbe-statistical-test-using-an-ipac-rs-database-of-delivered-dose-from-metered%C3%A2-dose-inhalers
#12
Beth Morgan, Stephanie Chen, David Christopher, Göran Långström, Christopher Wiggenhorn, Elise Burmeister Getz, Hayden Beresford, Thomas Hoffelder, Daniela Acerbi, Stephen Andrews, Mark Berry, Monisha Dey, Keyur Joshi, Mary McKenry, Marisa Pertile, Helen Strickland, David Wilcox, Svetlana Lyapustina
This article reports performance characteristics of the population bioequivalence (PBE) statistical test recommended by the US Food and Drug Administration (FDA) for orally inhaled products. A PBE Working Group of the International Pharmaceutical Aerosol Consortium on Regulation and Science (IPAC-RS) assembled and considered a database comprising delivered dose measurements from 856 individual batches across 20 metered dose inhaler products submitted by industry. A review of the industry dataset identified variability between batches and a systematic lifestage effect that was not included in the FDA-prescribed model for PBE...
February 12, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29435689/correction-to-pluripotent-stem-cell-derived-human-tissue-platforms-to-evaluate-drug-metabolism-and-safety
#13
Jose Meseguer-Ripolles, Salman R Khetani, Javier G Blanco, Miari Iredale, David C Hay
The original version of the published article contains errors throughout the text, which were introduced by the typesetter when performing the author's proof corrections.
February 12, 2018: AAPS Journal
https://www.readbyqxmd.com/read/29434543/altered-functional-connectivity-of-fronto-cingulo-striatal-circuits-during-error-monitoring-in-adolescents-with-a-history-of-childhood-abuse
#14
Heledd Hart, Lena Lim, Mitul A Mehta, Charles Curtis, Xiaohui Xu, Gerome Breen, Andrew Simmons, Kah Mirza, Katya Rubia
Childhood maltreatment is associated with error hypersensitivity. We examined the effect of childhood abuse and abuse-by-gene ( 5-HTTLPR, MAOA ) interaction on functional brain connectivity during error processing in medication/drug-free adolescents. Functional connectivity was compared, using generalized psychophysiological interaction (gPPI) analysis of functional magnetic resonance imaging (fMRI) data, between 22 age- and gender-matched medication-naïve and substance abuse-free adolescents exposed to severe childhood abuse and 27 healthy controls, while they performed an individually adjusted tracking stop-signal task, designed to elicit 50% inhibition failures...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29433578/resistant-hypertension-on-treatment-reshypot-sequential-nephron-blockade-compared-to-dual-blockade-of-the-renin-angiotensin-aldosterone-system-plus-bisoprolol-in-the-treatment-of-resistant-arterial-hypertension-study-protocol-for-a-randomized-controlled-trial
#15
Elizabeth do Espirito Santo Cestário, Letícia Aparecida Barufi Fernandes, Luiz Tadeu Giollo-Júnior, Jéssica Rodrigues Roma Uyemura, Camila Suemi Sato Matarucco, Manoel Idelfonso Paz Landim, Luciana Neves Cosenso-Martin, Lúcia Helena Bonalume Tácito, Heitor Moreno, José Fernando Vilela-Martin, Juan Carlos Yugar-Toledo
BACKGROUND: Resistant hypertension is characterized when the blood pressure (BP) remains above the recommended goal after taking three antihypertensive drugs with synergistic actions at their maximum recommended tolerated doses, preferably including a diuretic. Identifying the contribution of intravascular volume and serum renin in maintaining BP levels could help tailor more effective hypertension treatment, whether acting on the control of intravascular volume or sodium balance, or acting on the effects of the renin-angiotensin-aldosterone system (RAAS) on the kidney...
February 12, 2018: Trials
https://www.readbyqxmd.com/read/29433486/information-about-management-of-chronic-drug-therapies-prescribed-at-hospital-discharge-does-it-affect-patients-knowledge-and-self-confidence
#16
Claudia Pileggi, Emilia Caligiuri, Carmelo G A Nobile, Maria Pavia
BACKGROUND: Hospital stay represents the opportunity for a change of therapy, about which patients may not know indications, contraindications, and mode of administration, which may lead to dosing errors, drug interactions, side effects, etc. It is therefore vital to communicate appropriate information to the discharged patient with a new prescription drug. The purpose of the study was to evaluate: 1) how communication about new chronic therapies is managed at hospital discharge and what kind of information is provided to patients; 2) to what extent patients are aware and confident in the management of these medications; 3) whether the way communication is provided affects patients' awareness and self-confidence in the management of these therapies...
February 12, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29432763/-product-on-stopper-in-a-lyophilized-drug-product-cosmetic-defect-or-a-product-quality-concern
#17
Shyam B Mehta, Shouvik Roy, Han-Chang Cathy Yang
During manufacturing of a lyophilized drug product, operator errors in product handling during loading of product filled vials onto the lyophilizer can lead to a seemingly cosmetic defect which can impact certain critical quality attributes of finished product. In this study, filling of a formulated monoclonal antibody in vials was performed using a peristaltic pump filling unit and subsequently the product was lyophilized. Post lyophilization, upon visual inspection, around 40% of vials had cosmetic defect with residual product around stopper of the vial and were categorized as 'product on stopper' vials while remaining 60% vials with no cosmetic defect were called 'acceptable vials'...
February 9, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29432522/wdl-rf-predicting-bioactivities-of-ligand-molecules-acting-with-g-protein-coupled-receptors-by-combining-weighted-deep-learning-and-random-forest
#18
Jiansheng Wu, Qiuming Zhang, Weijian Wu, Tao Pang, Haifeng Hu, Wallace K B Chan, Xiaoyan Ke, Yang Zhang, Jonathan Wren
Motivation: Precise assessment of ligand bioactivities (including IC50, EC50, Ki, Kd, etc.) is essential for virtual screening and lead compound identification. However, not all ligands have experimentally-determined activities. In particular, many G protein-coupled receptors (GPCRs), which are the largest integral membrane protein family and represent targets of nearly 40% drugs on the market, lack published experimental data about ligand interactions. Computational methods with the ability to accurately predict the bioactivity of ligands can help efficiently address this problem...
February 8, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29432460/negative-interferences-by-calcium-dobesilate-in-the-detection-of-five-serum-analytes-involving-trinder-reaction-based-assays
#19
Xiuzhi Guo, Li'an Hou, Yicong Yin, Jie Wu, Fang Zhao, Liangyu Xia, Xinqi Cheng, Qian Liu, Li Liu, Ermu Xu, Ling Qiu
Previously, we reported the strong negative interference of calcium dobesilate, a vasoprotective agent, in creatinine assays involving the Trinder reaction. It is hypothesized that a similar effect occurs in the detection of uric acid (UA), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). The interferences of calcium dobesilate during the detection of the five serum analytes were investigated on automated systems/analysers, and the effects were compared among eight different assay systems for each analyte...
2018: PloS One
https://www.readbyqxmd.com/read/29428743/circulating-progesterone-concentrations-in-nonlactating-holstein-cows-during-reuse-of-intravaginal-progesterone-implants-sanitized-by-autoclave-or-chemical-disinfection
#20
L F Melo, P L J Monteiro, L H Oliveira, M M Guardieiro, J N Drum, M C Wiltbank, R Sartori
The aim of this study was to compare plasma progesterone (P4) concentrations in nonlactating, multiparous Holstein cows (n = 24) treated with 2 types of intravaginal implants containing either 1.0 or 1.9 g of P4 either at the first use or during reuse of the implants after sanitizing the implant by autoclave or chemical disinfection. In a completely randomized design with a 2 × 3 factorial arrangement and 2 replicates, every cow underwent 2 of 6 treatments. Two sources of P4 [controlled internal drug release (1...
February 7, 2018: Journal of Dairy Science
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