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https://www.readbyqxmd.com/read/28814886/a-practical-guide-to-the-handling-and-administration-of-talimogene-laherparepvec-in-europe
#1
REVIEW
Kevin J Harrington, Olivier Michielin, Josep Malvehy, Isabella Pezzani Grüter, Lorna Grove, Anna Lisa Frauchiger, Reinhard Dummer
Talimogene laherparepvec is a herpes simplex virus-1-based intralesional oncolytic immunotherapy and is the first oncolytic virus to be approved in Europe. It is indicated for the treatment of adults with unresectable melanoma that is regionally or distantly metastatic (stage IIIB, IIIC, and IVM1a) with no bone, brain, lung, or other visceral disease. Talimogene laherparepvec is a genetically modified viral therapy, and its handling needs special attention due to its deep freeze, cold-chain requirements, its potential for viral shedding, and its administration by direct intralesional injection...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28794532/local-anaesthetic-systemic-toxicity-following-oral-ingestion-in-a-child-revisiting-dibucaine
#2
Raylene Dias, Nandini Dave, Milind S Tullu, Chandrahas T Deshmukh
Dibucaine, a potent and toxic local anaesthetic, although currently withdrawn by the United States Food and Drug Administration for use as a spinal anaesthetic, continues to remain available in many over-the-counter topical formulations. Systemic toxicity following oral ingestion of local anaesthetics is rare. We report a case of accidental ingestion of dibucaine (ear drops) in a 7-year-old child who developed diplopia, giddiness, ventricular premature contractions and a right bundle branch block. We also present a brief discussion on the pharmacologic and toxicity profile of dibucaine, the Naranjo algorithm for assessing causality in case of adverse drug reactions and a review of current guidelines on the management of local anaesthetic systemic toxicity...
July 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/28766264/acetaminophen-paracetamol-induces-hypothermia-during-acute-cold-stress
#3
Josh Foster, Alexis R Mauger, Andrew Govus, David Hewson, Lee Taylor
BACKGROUND: Acetaminophen is an over-the-counter drug used to treat pain and fever, but it has also been shown to reduce core temperature (T c) in the absence of fever. However, this side effect is not well examined in humans, and it is unknown if the hypothermic response to acetaminophen is exacerbated with cold exposure. OBJECTIVE: To address this question, we mapped the thermoregulatory responses to acetaminophen and placebo administration during exposure to acute cold (10 °C) and thermal neutrality (25 °C)...
August 1, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28754237/treatment-of-larva-migrans-syndrome-with-long-term-administration-of-albendazole
#4
Amy Hombu, Ayako Yoshida, Taisei Kikuchi, Eiji Nagayasu, Mika Kuroki, Haruhiko Maruyama
BACKGROUND: Larva migrans syndrome is a food-borne parasitic disease in humans, caused by accidental ingestion of eggs or larvae of ascarid nematodes, namely, Toxocara canis, Toxocara cati, or Ascaris suum, the roundworms commonly found in the intestines of dogs, cats and pigs respectively. When a patient is diagnosed as having larva migrans syndrome, oral-administration of albendazole is recommended, however, the regimen remains controversial worldwide. In Japan, the duration of albendazole administration is longer than those of European and North American countries...
July 14, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28742772/medication-errors-in-pediatric-anesthesia-a-report-from-the-wake-up-safe-quality-improvement-initiative
#5
Lauren M Y Lobaugh, Lizabeth D Martin, Laura E Schleelein, Donald C Tyler, Ronald S Litman
BACKGROUND: Wake Up Safe is a quality improvement initiative of the Society for Pediatric Anesthesia that contains a deidentified registry of serious adverse events occurring in pediatric anesthesia. The aim of this study was to describe and characterize reported medication errors to find common patterns amenable to preventative strategies. METHODS: In September 2016, we analyzed approximately 6 years' worth of medication error events reported to Wake Up Safe. Medication errors were classified by: (1) medication category; (2) error type by phase of administration: prescribing, preparation, or administration; (3) bolus or infusion error; (4) provider type and level of training; (5) harm as defined by the National Coordinating Council for Medication Error Reporting and Prevention; and (6) perceived preventability...
September 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28739010/removal-contents
#6
(no author information available yet)
This article has been removed: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). Due to an administrative error, an issue was accidentally published here. This has now been removed. The publisher apologises for any inconvenience this may cause.
March 2017: Brain & Development
https://www.readbyqxmd.com/read/28739009/removal-editorial-board
#7
(no author information available yet)
This article has been removed: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). Due to an administrative error, an issue was accidentally published here. This has now been removed. The publisher apologises for any inconvenience this may cause.
March 2017: Brain & Development
https://www.readbyqxmd.com/read/28739008/removal-cover
#8
(no author information available yet)
This article has been removed: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). Due to an administrative error, an issue was accidentally published here. This has now been removed. The publisher apologises for any inconvenience this may cause.
March 2017: Brain & Development
https://www.readbyqxmd.com/read/28739007/removal-announcements-and-reports
#9
(no author information available yet)
This article has been removed: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). Due to an administrative error, an issue was accidentally published here. This has now been removed. The publisher apologises for any inconvenience this may cause.
March 2017: Brain & Development
https://www.readbyqxmd.com/read/28739006/removal-sp_abstract
#10
(no author information available yet)
This article has been removed: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). Due to an administrative error, an issue was accidentally published here. This has now been removed. The publisher apologises for any inconvenience this may cause.
March 2017: Brain & Development
https://www.readbyqxmd.com/read/28739005/removal-ms_abstract
#11
(no author information available yet)
This article has been removed: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). Due to an administrative error, an issue was accidentally published here. This has now been removed. The publisher apologises for any inconvenience this may cause.
March 2017: Brain & Development
https://www.readbyqxmd.com/read/28739004/removal-ls_abstract
#12
(no author information available yet)
This article has been removed: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). Due to an administrative error, an issue was accidentally published here. This has now been removed. The publisher apologises for any inconvenience this may cause.
March 2017: Brain & Development
https://www.readbyqxmd.com/read/28739003/removal-ps_abstract
#13
(no author information available yet)
This article has been removed: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). Due to an administrative error, an issue was accidentally published here. This has now been removed. The publisher apologises for any inconvenience this may cause.
March 2017: Brain & Development
https://www.readbyqxmd.com/read/28739002/removal-sts_abstract
#14
(no author information available yet)
This article has been removed: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). Due to an administrative error, an issue was accidentally published here. This has now been removed. The publisher apologises for any inconvenience this may cause.
March 2017: Brain & Development
https://www.readbyqxmd.com/read/28739001/removal-s_abstract
#15
(no author information available yet)
This article has been removed: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). Due to an administrative error, an issue was accidentally published here. This has now been removed. The publisher apologises for any inconvenience this may cause.
March 2017: Brain & Development
https://www.readbyqxmd.com/read/28739000/removal-ts_abstract
#16
(no author information available yet)
This article has been removed: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). Due to an administrative error, an issue was accidentally published here. This has now been removed. The publisher apologises for any inconvenience this may cause.
March 2017: Brain & Development
https://www.readbyqxmd.com/read/28738999/removal-p3_abstract
#17
(no author information available yet)
This article has been removed: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). Due to an administrative error, an issue was accidentally published here. This has now been removed. The publisher apologises for any inconvenience this may cause.
March 2017: Brain & Development
https://www.readbyqxmd.com/read/28738998/removal-pcl_abstract
#18
(no author information available yet)
This article has been removed: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). Due to an administrative error, an issue was accidentally published here. This has now been removed. The publisher apologises for any inconvenience this may cause.
March 2017: Brain & Development
https://www.readbyqxmd.com/read/28738997/removal-kl_abstract
#19
(no author information available yet)
This article has been removed: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). Due to an administrative error, an issue was accidentally published here. This has now been removed. The publisher apologises for any inconvenience this may cause.
March 2017: Brain & Development
https://www.readbyqxmd.com/read/28738996/removal-pos_abstract
#20
(no author information available yet)
This article has been removed: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). Due to an administrative error, an issue was accidentally published here. This has now been removed. The publisher apologises for any inconvenience this may cause.
March 2017: Brain & Development
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