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https://www.readbyqxmd.com/read/28548574/overdose-education-and-naloxone-distribution-for-veterans-with-opioid-use-disorder-results-from-a-pilot-initiative
#1
Grace Chang, Michelle Davids, Alan Kershaw
Background Patients with opioid use disorder (OUD) are at high risk of overdose. To minimize that risk, a program offering intranasal naloxone rescue kits was piloted at a Veterans Administration Hospital. The purpose of this study was to characterize the veterans who accepted these potentially lifesaving kits. Methods Retrospective medical chart review of 158 veterans with OUD receiving treatment on either the inpatient psychiatry detoxification units or outpatient methadone maintenance setting who were offered overdose education and naloxone rescue (OEND) kits...
May 26, 2017: Journal of Addictive Diseases
https://www.readbyqxmd.com/read/28543100/syndecan-1-limits-the-progression-of-liver-injury-and-promotes-liver-repair-in-acetaminophen-induced-liver-injury
#2
Eon Jeong Nam, Kazutaka Hayashida, Rafael S Aquino, John R Couchman, Rosemary A Kozar, Jian Liu, Pyong Woo Park
Accidental or intentional misuse of acetaminophen (APAP) is the leading cause of acute liver failure in the Western world. While mechanisms that trigger APAP-induced liver injury are well known, those that halt the progression of APAP liver disease and facilitate liver recovery are less understood. Heparan sulfate proteoglycans (HSPGs) bind to and regulate various tissue injury factors through their heparan sulfate (HS) chains, but the importance of HSPGs in liver injury in vivo remains unknown. Here, we examined the role of syndecan-1, the major cell surface HSPG of hepatocytes, in APAP-induced liver injury...
May 22, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28511410/preventive-training-among-medical-interns-in-mexico-city-and-its-association-with-needlestick-and-sharp-injuries-a-cross-sectional-study
#3
Victor Hugo Garcia, Katja Radon
INTRODUCTION: Medical students are a vulnerable group for the acquisition of blood borne pathogens due to their lack of experience. In Europe and Asia preventive training programs have reduced accidental exposures. AIM: The aim of the study was to compare the lifetime prevalence of Needlestick and Sharp Objects Injuries (NSIs) among medical interns who received preventive training versus those without such training in Mexico City. MATERIALS AND METHODS: In 2013, a cross-sectional study was performed applying an anonymous self-administrated questionnaire...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28502090/successful-use-of-lipid-emulsion-to-resuscitate-a-foal-after-intravenous-lidocaine-induced-cardiovascular-collapse
#4
V Vieitez, I Á Gómez de Segura, M Martin-Cuervo, L Alfonso Gracia, L Javier Ezquerra
BACKGROUND: Lipid emulsion has been reported to be effective for the treatment of local anaesthetic overdoses in rats, dogs and humans. OBJECTIVES: To describe the successful treatment of cardiovascular lidocaine toxicity in a foal with intravenous lipid administration. STUDY DESIGN: Observational study: case report. METHODS: An 8-month-old Arabian cross foal was anaesthetised for removal of the right alar fold and nasal plate...
May 14, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28498176/effectiveness-of-haloperidol-prophylaxis-in-critically-ill-patients-with-a-high-risk-of-delirium-a-systematic-review
#5
Eduardo Santos, Daniela Cardoso, Hugo Neves, Madalena Cunha, Manuel Rodrigues, João Apóstolo
BACKGROUND: Delirium is associated with increased intensive care unit and hospital length of stay, prolonged duration of mechanical ventilation, unplanned removal of tubes and catheters, and increased morbidity and mortality. Prophylactic treatment with low-dose haloperidol may have beneficial effects for critically ill patients with a high risk of delirium. OBJECTIVES: To identify the effectiveness of haloperidol prophylaxis in critically ill patients with a high risk for delirium...
May 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28492168/accidental-intravenous-administration-of-paracetamol-syrup-in-a-child
#6
D El Mazloum, A Boner, A Pietrobelli
OBJECTIVE AND IMPORTANCE: Medication administration errors occur frequently in clinical practice. CLINICAL PRESENTATION: An 18-month-old child presented with vomiting and diarrhea. Due to a rise in temperature, paracetamol syrup was prescribed, but a nurse inadvertently administered the drug IV through the peripheral venous access. INTERVENTION: The child was referred to the pediatric intensive care unit where his clinical condition improved and the risk of peripheral venous and pulmonary embolism was excluded...
December 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28487840/medical-certification-reduces-the-number-of-children-requiring-allergen-elimination-diets-for-school-lunches
#7
Seigo Korematsu, Kenji Toyokuni, Yousuke Handa, Chika Gotoh, Rieko Wasada, Rie Kato, Nanae Kawano, Mayo Ikeuchi, Tomoko Okamoto, Maki Kiriya, Mizuho Takahashi, Tomoyuki Takano, Atsuhiko Haigo
BACKGROUND: Following the increase in the number of children with food allergies, support systems are now required for school lunches, but a large-scale factual investigation has not been carried out. OBJECTIVE: We evaluated the features of elimination diet due to food allergy and the support system in kindergartens and schools. METHODS: A prefecture-based questionnaire survey regarding measures for food allergies in school lunches of all kindergartens, public elementary schools, and public junior high schools (631 facilities) was conducted in Oita Prefecture, Japan...
April 2017: Asia Pacific Allergy
https://www.readbyqxmd.com/read/28451577/expression-levels-of-two-dna-repair-related-genes-under-8-gy-ionizing-radiation-and-100-mg-kg-melatonin-delivery-in-rat-peripheral-blood
#8
M Valizadeh, A Shirazi, P Izadi, J Tavakkoly Bazzaz, H Rezaeejam
BACKGROUND: After radiation therapy (RT), some health hazards including DNA damages may occur where melatonin can play a protective role due to free radical generation. On the other hand, serious accidental overexposures may occur during RT due to nuclear accidents which necessitate the need for study on exposure to high-dose radiations during treatments. OBJECTIVE: The aim of this study was to study the expression level of two genes in non-homologous end joining (NHEJ) pathways named Xrcc4 and Xrcc6 (Ku70) in order to examine the effect of melatonin on repair of DNA double-strand breaks (BSBs) caused by 8Gy ionizing radiation...
March 2017: Journal of Biomedical Physics & Engineering
https://www.readbyqxmd.com/read/28427112/acute-encephalopathy-in-a-2-year-old-pot-bellied-pig-following-accidental-intoxication-with-clonazepam
#9
Emilie L Setlakwe, Amy L Johnson
OBJECTIVE: To describe a case of successful management of clonazepam toxicity causing encephalopathy in a pot-bellied pig. CASE SUMMARY: A 2-year-old female pot-bellied pig weighing 13.5 kg was presented for evaluation of clinical signs of acute encephalopathy. Based on the animal's history and clinical signs, a tentative diagnosis of benzodiazepine (BZP) intoxication was made. The results of a urinary drug screening test designed to detect illicit substances in human urine indicated benzodiazepine exposure...
May 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28416008/a-guide-to-acquired-vitamin-k-coagulophathy-diagnosis-and-treatment-the-russian-perspective
#10
REVIEW
Valery V Wojciechowski, Daniela Calina, Konstantinos Tsarouhas, Alexander V Pivnik, Alexander A Sergievich, Vladimir V Kodintsev, Ekaterina A Filatova, Eren Ozcagli, Anca Oana Docea, Andreea Letitia Arsene, Eliza Gofita, Christina Tsitsimpikou, Aristidis M Tsatsakis, Kirill S Golokhvast
Physicians often come across with cases of vitamin K antagonists-dependent coagulopathy for reasons such as accidental use of the vitamin K antagonists (VKA), excessive administration of prescribed anticoagulants of indirect action or not reported administration of vitamin K antagonists due to memory impairment and/or other mental disorders, even deliberate use thereof (attempt to murder or suicide). Rodenticide-poisoning (coumarins, warfarins) via food or occupational accidents are difficult to diagnose. This article discusses different types of acquired vitamin K-dependent coagulopathy...
April 17, 2017: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/28415945/pseudomonas-aeruginosa-endophthalmitis-caused-by-accidental-iatrogenic-ocular-injury-with-a-hypodermic-needle
#11
Cheng-Wei Lu, Ji-Long Hao, Xiu-Fen Liu, Ling-Ling Liang, Dan-Dan Zhou
Iatrogenic traumatic endophthalmitis is a rare but serious ocular infection that can lead to severe vision loss. A 44-year-old man presented with pain and decreased vision in the right eye 4 hours after injury with a hypodermic needle during irrigation of his eye. Slit-lamp examination revealed a penetrating corneal puncture and iris hole in the right eye. Twenty hours later, his visual acuity had decreased to hand motion, and severe fibrinoid uveitis was noted. He immediately underwent irrigation of the anterior chamber and intravitreal antibiotic injection...
April 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28356773/update-on-the-usage-and-safety-of-epinephrine-auto-injectors-2017
#12
REVIEW
Larry S Posner, Carlos A Camargo
Anaphylaxis is a serious, potentially fatal allergic reaction. Guidelines recommend prompt intramuscular injections of epinephrine as the first-line therapy for anaphylaxis. Delayed epinephrine treatment may cause undesirable clinical outcomes, including death. In the community, epinephrine auto-injectors (EAIs) are commonly used to treat anaphylaxis. This literature review examines several recent concerns regarding the safety of EAIs that may prevent the timely administration of epinephrine. Reports of cardiovascular complications are linked with epinephrine administration, although recent studies suggest that these events are much more commonly associated with intravenous epinephrine rather than with EAIs...
2017: Drug, Healthcare and Patient Safety
https://www.readbyqxmd.com/read/28348732/probuphine%C3%A2-buprenorphine-implant-a-promising-candidate-in-opioid-dependence
#13
REVIEW
Preeti Barnwal, Saibal Das, Somnath Mondal, Anand Ramasamy, Tanay Maiti, Arunava Saha
Opioid dependence leads to physical dependence and addiction which finally results in profound medical, psychological and social dysfunction. One of the useful medications for opioid dependence is buprenorphine, the partial opioid agonist, which is used alone or in combination with naloxone. However, buprenorphine is the victim of its own success due to its illicit use and accidental poisoning in children. Also, buprenorphine typically requires daily self-administration and its effectiveness heavily depends on patient adherence...
March 2017: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/28328690/the-first-use-of-pralidoxime-in-a-child-with-rivastigmine-poisoning
#14
Eylem Ulaş Saz, Ali Yurtseven, Mehmet Arda Kilinç, Yusuf Sari, Hasan Ağin
The aim of this report is to describe the successful use of pralidoxime in a pediatric patient who accidentally ingested 12 mg of rivastigmine and presented to the emergency department with weakness, drowsiness, hyporeactivity to environmental stimuli, and full cholinergic syndrome. CASE: The patient presented to the emergency department 2 hours after a suspected ingestion of rivastigmine. He was sleepy but oriented and cooperative, hypotonic, and hyporeflexic and has a Glasgow Coma Scale score of 13 (E3M6V4)...
March 21, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28316435/delta-check-for-blood-groups-a-step-ahead-in-blood-safety
#15
Raj Nath Makroo, Aakanksha Bhatia
BACKGROUND: Blood grouping is the single most important test performed by each and every transfusion service. A blood group error has a potential for causing severe life-threatening complications. A number of process strategies have been adopted at various institutions to prevent the occurrence of errors at the time of phlebotomy, pretransfusion testing, and blood administration. A delta check is one such quality control tool that involves the comparison of laboratory test results with results obtained on previous samples from the same patient...
January 2017: Asian Journal of Transfusion Science
https://www.readbyqxmd.com/read/28270885/does-accidental-overcorrection-of-symptomatic-hyponatremia-in-chronic-heart-failure-require-specific-therapeutic-adjustments-for-preventing-central-pontine-myelinolysis
#16
REVIEW
Renato De Vecchis, Michel Noutsias, Carmelina Ariano, Arturo Cesaro, Carmela Cioppa, Anna Giasi, Nicola Maurea
This review aims at summarizing essential aspects of epidemiology and pathophysiology of hyponatremia in chronic heart failure (CHF), to set the ground for a practical as well as evidence-based approach to treatment. As a guide through the discussion of the available evidence, a clinical case of hyponatremia associated with CHF is presented. For this case, the severe neurological signs at presentation justified an emergency treatment with hypertonic saline plus furosemide, as indicated. Subsequently, as the neurological emergency began to subside, the reversion of the trend toward hyponatremia overcorrection was realized by continuous infusion of hypotonic solutions, and administration of desmopressin, so as to prevent the very feared risk of an osmotic demyelination syndrome...
April 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28243726/short-term-effects-of-air-quality-and-thermal-stress-on-non-accidental-morbidity-a-multivariate-meta-analysis-comparing-indices-to-single-measures
#17
Hanna Leona Lokys, Jürgen Junk, Andreas Krein
Air quality and thermal stress lead to increased morbidity and mortality. Studies on morbidity and the combined impact of air pollution and thermal stress are still rare. To analyse the correlations between air quality, thermal stress and morbidity, we used a two-stage meta-analysis approach, consisting of a Poisson regression model combined with distributed lag non-linear models (DLNMs) and a meta-analysis investigating whether latitude or the number of inhabitants significantly influence the correlations...
February 28, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28226319/oral-and-sublingual-immunotherapy-potential-causes-for-eosinophilic-gastrointestinal-disorders
#18
REVIEW
Delara Babaie, Mehrnaz Mesdaghi, Makoto Nishino, Mahboubeh Mansouri, Motohiro Ebisawa
Food allergy is a common health problem worldwide, with increasing prevalence during recent decades. The only approved treatments for food allergy are food avoidance and administration of emergency medications in case of accidental exposure, which negatively affects patients' quality of life, so new treatments are highly desirable. Different food immunotherapy modalities have recently been used, with variable success rates in the induction of desensitization and tolerance, and different numbers and types of adverse reactions...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28212883/nonlinear-relationship-between-extreme-temperature-and-mortality-in-different-temperature-zones-a-systematic-study-of-122-communities-across-the-mainland-of-china
#19
Chenzhi Wang, Zhao Zhang, Maigeng Zhou, Lingyan Zhang, Peng Yin, Wan Ye, Yi Chen
BACKGROUND: Numerous previous studies have reported that human health risk is extremely sensitive to temperature. Very few studies, however, have characterized the relationship between temperature and mortality in different temperature zones due to the previous conclusions deduced from a regional or administrative division. A research covers different temperature zones was indispensable to have a comprehensive understanding of regional ambient temperature effect on public health. METHODS: Based on the mortality dataset and meteorological variables of 122 communities in China from 2007 to 2012, a distributed lag nonlinear model (DLNM) was utilized to estimate the temperature effect on non-accidental mortality at the community level...
May 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28211644/healthcare-professionals-and-pharmacovigilance-of-pediatric-adverse-drug-reactions-a-5-year-analysis-of-adverse-events-reporting-system-database-of-the-food-and-drug-administration
#20
Caterina Bigi, Marco Tuccori, Guido Bocci
BACKGROUND: To analyze the Adverse Events Reporting System (AERS) database of the Food and Drug Administration (FDA), investigating the characteristics of pediatric adverse drug reactions (ADRs) and describing the effective participation of healthcare professionals in the reporting activity. METHODS: Reports of ADRs were obtained from the FDA website. Only ADRs in pediatric subjects (divided by age, by country and by professional category) were included into the analysis...
February 17, 2017: Minerva Pediatrica
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