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resolvins

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https://www.readbyqxmd.com/read/29197557/soy-flour-as-an-alternative-to-purified-lipoxygenase-for-the-enzymatic-synthesis-of-resolvin-analogues
#1
Hoang-Anh T Tu, Eleanor P Dobson, Luke C Henderson, Colin J Barrow, Jacqui L Adcock
Specialized pro-resolving mediators are lipid signaling molecules synthesized from omega-3 and -6 polyunsaturated fatty acids, which promote the resolution of the inflammatory response. They are potential drug targets for the treatment of numerous conditions linked with uncontrolled inflammation. Many of these mediators can be effectively synthesized using enzymes, such as lipoxygenases. However, these enzymes are expensive to purchase and can be difficult to isolate. In this work, we show that commercial soy flour can be used directly as a source of lipoxygenase for the biosynthesis of specialized pro-resolving mediators from DHA and other biologically important fatty acids...
November 29, 2017: New Biotechnology
https://www.readbyqxmd.com/read/29191914/resolvins-suppress-tumor-growth-and-enhance-cancer-therapy
#2
Megan L Sulciner, Charles N Serhan, Molly M Gilligan, Dayna K Mudge, Jaimie Chang, Allison Gartung, Kristen A Lehner, Diane R Bielenberg, Birgitta Schmidt, Jesmond Dalli, Emily R Greene, Yael Gus-Brautbar, Julia Piwowarski, Tadanori Mammoto, David Zurakowski, Mauro Perretti, Vikas P Sukhatme, Arja Kaipainen, Mark W Kieran, Sui Huang, Dipak Panigrahy
Cancer therapy reduces tumor burden by killing tumor cells, yet it simultaneously creates tumor cell debris that may stimulate inflammation and tumor growth. Thus, conventional cancer therapy is inherently a double-edged sword. In this study, we show that tumor cells killed by chemotherapy or targeted therapy ("tumor cell debris") stimulate primary tumor growth when coinjected with a subthreshold (nontumorigenic) inoculum of tumor cells by triggering macrophage proinflammatory cytokine release after phosphatidylserine exposure...
November 30, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29173199/effects-of-prenatal-n-3-fatty-acid-supplementation-on-offspring-resolvins-at-birth-and-12-years-of-age-a-double-blind-randomised-controlled-clinical-trial
#3
Valene H L See, Emilie Mas, Susan L Prescott, Lawrence J Beilin, Sally Burrows, Anne E Barden, Rae-Chi Huang, Trevor A Mori
Resolution of inflammation is an active process involving specialised pro-resolving mediators (SPM) generated from the n-3 fatty acids EPA and DHA. n-3 Fatty acid supplementation during pregnancy may provide an intervention strategy to modify these novel SPM. This study aimed to assess the effect of n-3 fatty acid supplementation in pregnancy on offspring SPM at birth and 12 years of age (12 years). In all, ninety-eight atopic pregnant women were randomised to 3·7 g daily n-3 fatty acids or a control (olive oil), from 20 weeks gestation until delivery...
November 27, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29154839/participation-of-the-anti-inflammatory-and-antioxidative-activity-of-docosahexaenoic-acid-on-indomethacin-induced-gastric-injury-model
#4
Elizabeth Arlen Pineda-Peña, Yoalli Martínez-Pérez, Marina Galicia-Moreno, Araceli Navarrete, José Segovia, Pablo Muriel, Liliana Favari, Gilberto Castañeda-Hernández, Aracely Evangelina Chávez-Piña
Adverse gastrointestinal (GI) effects caused by nonsteroidal anti-inflammatory drugs (NSAIDs), including indomethacin, are recognized as the major limitation to their clinical use. NSAID-induced gastric damage is generated by cyclooxygenase inhibition, activation of inflammatory processes, and oxidative stress. Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid, has shown gastroprotective effects; however, the molecular mechanisms underlying these effects have not been fully explained. As a result, the aim of this study was to examine DHA's anti-inflammatory and antioxidative actions in a mouse model of indomethacin-induced gastric injury...
November 14, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29137840/resolvin-d1-attenuates-imiquimod-induced-mice-psoriasiform-dermatitis-through-mapks-and-nf-%C3%AE%C2%BAb-pathways
#5
Juntao Xu, Xiaoru Duan, Feng Hu, Devesh Poorun, Xinxin Liu, Xin Wang, Song Zhang, Lu Gan, Mengwen He, Ke Zhu, Zhangyin Ming, Hongxiang Chen
BACKGROUND: Resolvin D1 (RvD1), a pro-resolution lipid mediator derived from docosahexaenoic acid (DHA), has been described to promote several kinds of inflammatory resolution. However, the effects and anti-inflammatory mechanisms of RvD1 on psoriasis have not been previously reported. OBJECTIVE: The present study aimed to determine the protective effects and the underlying mechanisms of RvD1 on imiquimod (IMQ)-induced psoriasiform dermatitis. METHODS: Mice were topically treated with IMQ to develop psoriasiform dermatitis on their shaved back, pretreated intraperitoneally (i...
November 11, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29134121/omega-3-fatty-acids-in-atherosclerosis-and-coronary-artery-disease
#6
REVIEW
Magnus Bäck
Omega-3 polyunsaturated fatty acids have emerged as possible protective factors associated with a decreased risk for myocardial infarction in populations with a high marine food intake, which may relate to effects on lipid metabolism, thrombosis and inflammation. Omega-3 fatty acids decrease triglyceride levels and also compete as substrates for enzymes involved in the biosynthesis of lipid mediators. The balance between omega-3-derived specialized proresolving mediators and pro-inflammatory lipid mediators from arachidonic acid metabolism can be measured as the resolvin-to-leukotriene ratio, which has been shown to predict subclinical atherosclerosis...
November 2017: Future Science OA
https://www.readbyqxmd.com/read/29126887/combined-administration-of-resolvin-e1-and-lipoxin-a4-resolves-inflammation-in-a-murine-model-of-alzheimer-s-disease
#7
Alpdogan Kantarci, Nurgul Aytan, Iro Palaska, Danielle Stephens, Leah Crabtree, Claudia Benincasa, Bruce G Jenkins, Isabel Carreras, Alpaslan Dedeoglu
Dysfunction in the resolution of inflammation may play a key role in Alzheimer's disease (AD). In this study, we found that the levels of specialized pro-resolving lipid mediators (SPMs) in the hippocampus of 5xFAD mice are significantly lower than in non-transgenic littermates. We, therefore, tested the hypothesis that treatment with resolvin E1 (RvE1) and lipoxin A4 (LXA4) alone or in combination will reverse the neuroinflammatory process and decrease Aβ pathology. 5xFAD mice were treated intraperitoneally starting at 1month of age with RvE1 or LXA4 alone or in combination at a dose of 1...
November 7, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29110146/atherosclerosis-periodontal-disease-and-treatment-with-resolvins
#8
REVIEW
James A Hamilton, Hatice Hasturk, Alpdogan Kantarci, Charles N Serhan, Thomas Van Dyke
PURPOSE OF REVIEW: This review aims to discuss the existing evidence on the link between atherosclerosis and periodontitis by particularly presenting new findings that link the pathology and therapy of these diseases. Acute vascular ischemic events that can lead to stroke or myocardial infarction are initiated by inflammatory processes leading to rupture or erosion of plaques susceptible to thrombosis ("high risk" or "vulnerable"). These are highly inflamed plaques residing in the media and adventitia that may not be detected by angiography measurments of luminal narrowing...
November 6, 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29109025/fish-oil-feeding-attenuates-neuroinflammatory-gene-expression-without-concomitant-changes-in-brain-eicosanoids-and-docosanoids-in-a-mouse-model-of-alzheimer-s-disease
#9
Kathryn E Hopperton, Marc-Olivier Trépanier, Nicholas C E James, Raphaël Chouinard-Watkins, Richard P Bazinet
BACKGROUND: Neuroinflammation is a recognized hallmark of Alzheimer's disease, along with accumulation of amyloid-β plaques, neurofibrillary tangles and synaptic loss. n-3 polyunsaturated fatty acids (PUFA) and molecules derived from them, including eicosapentaenoic acid-derived eicosanoids and docosahexaenoic acid-derived docosanoids, are known to have both anti-inflammatory and pro-resolving properties, while human observational data links consumption of these fatty acids to a decreased risk of Alzheimer's disease...
November 3, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29103035/immunotherapy-of-mild-cognitive-impairment-by-%C3%AF-3-supplementation-why-are-amyloid-%C3%AE-antibodies-and-%C3%AF-3-not-working-in-clinical-trials
#10
Milan Fiala, Lucas Restrepo, Matteo Pellegrini
This article reviews the basic tenets of a clinical approach to effective immunotherapy of Alzheimer's disease (AD) in patients with mild cognitive impairment (MCI). Although one randomized controlled study in early MCI patients by fish-derived omega-3 fatty acids (ω-3) showed slowing of disease progression, large clinical trials with different products have failed to show cognitive effects. Macrophages of healthy subjects phagocytize and degrade amyloid-β1 - 42 (Aβ) in the brain tissues, whereas macrophages of patients with AD and MCI are functionally defective...
October 30, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29095817/a-regulatory-role-for-%C3%AE-adrenergic-receptors-regarding-the-resolvin-d1-rvd1-pathway-in-the-diabetic-retina
#11
Haoshen Shi, Thomas W Carion, Youde Jiang, Adam Chahine, Jena J Steinle, Elizabeth A Berger
Diabetic retinopathy is a visually debilitating disease with limited treatment options available. Compound 49b, a β-adrenergic receptor agonist, has been demonstrated to effectively reduce disease pathogenesis associated with diabetic retinopathy. While the exact mechanisms are not fully understood, previous studies have determined that it reduces the pro-inflammatory cytokine, TNF-α, and inhibits apoptosis of the retinal microvasculture. As inflammation becomes more recognized in driving disease pathogenesis, so does the regulation by pro-resolving pathways as therapeutic points of intervention...
2017: PloS One
https://www.readbyqxmd.com/read/29090333/resolvin-e1-e2-ameliorate-lipopolysaccharide-induced-depression-like-behaviors-via-chemr23
#12
Satoshi Deyama, Kento Shimoda, Hiroe Suzuki, Yuka Ishikawa, Kohei Ishimura, Hayato Fukuda, Natsuko Hitora-Imamura, Soichiro Ide, Masamichi Satoh, Katsuyuki Kaneda, Satoshi Shuto, Masabumi Minami
RATIONALE: Resolvins are bioactive lipid mediators that are generated from docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). We recently demonstrated that the DHA-derived resolvins D1 and D2 exert antidepressant effects. However, whether the EPA-derived resolvins E1 (RvE1) and E2 (RvE2) produce antidepressant effects is not clear. OBJECTIVES: We examined the antidepressant effects of RvE1/RvE2 in a murine lipopolysaccharide (LPS)-induced depression model using the tail suspension and forced swim tests...
October 31, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29083412/resolvind1-stimulates-epithelial-wound-repair-and-inhibits-tgf-%C3%AE-induced-emt-whilst-reducing-fibroproliferation-and-collagen-production
#13
Shengxing Zheng, Qian Wang, Vijay D'Souza, Dom Bartis, Rachel Dancer, Dhruv Parekh, Fang Gao, Qingquan Lian, Shengwei Jin, David R Thickett
Acute and chronic inflammatory lung diseases are often associated with epithelial cell injury/loss and fibroproliferative responses. ResolvinD1 (RvD1) is biosynthesized during the resolution phase of inflammatory response and exerts potent anti-inflammatory and promotes resolution of inflammatory lung diseases. The aim of this study was to investigate whether RvD1 exerts protective effects on alveolar epithelial cell function/differentiation and protects against fibroproliferative stimuli. Primary human alveolar type II cells were used to model the effects of RvD1 in vitro upon wound repair, proliferation, apoptosis, transdifferentiation, and epithelial-mesenchymal transition (EMT)...
October 30, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29073216/prolonged-immune-alteration-following-resolution-of-acute-inflammation-in-humans
#14
Madhur P Motwani, Justine Newson, Simon Kwong, Angela Richard-Loendt, Romain Colas, Jesmond Dalli, Derek W Gilroy
Acute inflammation is an immediate response to infection and injury characterised by the influx of granulocytes followed by phagocytosing mononuclear phagocytes. Provided the antigen is cleared and the immune system of the host is fully functional, the acute inflammatory response will resolve. Until now it is considered that resolution then leads back to homeostasis, the physiological state tissues experienced before inflammation occurred. Using a human model of acute inflammation driven by intradermal UV killed Escherichia coli, we found that bacteria and granulocyte clearance as well as pro-inflammatory cytokine catabolism occurred by 72h...
2017: PloS One
https://www.readbyqxmd.com/read/29034833/drug-therapy-for-abdominal-aortic-aneurysms-utilizing-omega-3-unsaturated-fatty-acids-and-their-derivatives
#15
Daisuke Akagi, Katsuyuki Hoshina, Toshiaki Watanabe, Micheal S Conte
Abdominal aortic aneurysms (AAA) are life-threatening because of the potential for rupture, resulting in death. The current standard treatment for AAA is surgery, comprising laparotomic graft replacement and endovascular repair. However, because surgery carries the risk of major complications and re-intervention, medical therapies are desirable because they may reduce the occurrence of enlargement and rupture. Recent research shows that the progression of AAA is related to inflammatory reactions, especially those in the NF-kB pathway...
October 13, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/29031390/effects-of-postnatal-omega-3-fatty-acid-supplementation-on-offspring-pro-resolving-mediators-of-inflammation-at-6-months-and-5-years-of-age-a-double-blind-randomized-controlled-clinical-trial
#16
V H L See, E Mas, S L Prescott, L J Beilin, S Burrows, A E Barden, R C Huang, T A Mori
BACKGROUND: Resolution of inflammation is an active process involving specialised pro-resolving mediators (SPMs) generated from the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Omega-3 fatty acid supplementation during infancy may provide an intervention strategy to modify SPMs and reduce oxidative stress. This study evaluates the effect of omega-3 fatty acid supplementation in infancy on SPMs and F2-isoprostanes from 6 months to 5 years of age. METHODS: In a double-blind, placebo-controlled, parallel-group study design, 420 infants were randomized to a daily supplement of omega-3 fatty acids (280mg DHA and 110mg EPA) or olive oil (control), from birth to age 6 months...
November 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29021582/novel-mechanism-of-regulation-of-the-5-lipoxygenase-leukotriene-b4-pathway-by-high-density-lipoprotein-in-macrophages
#17
Shigeyasu Tsuda, Masakazu Shinohara, Toshihiko Oshita, Manabu Nagao, Nobuaki Tanaka, Takeshige Mori, Tetsuya Hara, Yasuhiro Irino, Ryuji Toh, Tatsuro Ishida, Ken-Ichi Hirata
High-density lipoprotein (HDL) interacts with various cells, particularly macrophages, in functional cell-HDL interactions. Here, we found that HDL protein quality and lipid quality play critical roles in HDL functions. HDL fractions from healthy volunteers (HDLHealthy) and patients with recurrent coronary atherosclerotic disease (HDLCAD) were prepared. To analyse functional HDL-macrophage interactions, macrophages were co-incubated with each HDL, and lipid mediator production was assessed by liquid chromatography/mass spectrometry-based metabololipidomics...
October 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29021496/comparison-of-the-distribution-of-unsaturated-fatty-acids-at-the-sn-2-position-of-phospholipids-and-triacylglycerols-in-marine-fishes-and-mammals
#18
Fumiaki Beppu, Keiko Yasuda, Ayako Okada, Yoshitsugu Hirosaki, Masako Okazaki, Naohiro Gotoh
Highly unsaturated fatty acid (HUFA) binding at the sn-2 position of phospholipids (PL) becomes a resource for prostaglandin, leukotriene, resolvin, and protectin synthesis. Both triacylglycerol (TAG) and PL synthesis pathways in vivo are via phosphatidic acid; therefore, the distribution of fatty acid species at the sn-2 position must theoretically be the same for TAG and PL if rearrangement does not occur. However, it is known that little HUFA is located at the sn-2 position of TAG in marine mammals. Therefore, distribution of fatty acid species at the sn-2 position of TAG and PL was compared between marine fishes and mammals in this study...
October 11, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28993702/erv1-overexpression-in-myeloid-cells-protects-against-high-fat-diet-induced-obesity-and-glucose-intolerance
#19
Corneliu Sima, Eduardo Montero, Daniel Nguyen, Marcelo Freire, Paul Norris, Charles N Serhan, Thomas E Van Dyke
Non-resolving inflammation is a central pathologic component of obesity, insulin resistance, type 2 diabetes and associated morbidities. The resultant hyperglycemia is deleterious to the normal function of many organs and its control significantly improves survival and quality of life for patients with diabetes. Macrophages play critical roles in both onset and progression of obesity-associated insulin resistance. Here we show that systemic activation of inflammation resolution prevents from morbid obesity and hyperglycemia under dietary overload conditions...
October 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28987721/circulating-inflammation-resolving-lipid-mediators-rvd1-and-dha-are-decreased-in-patients-with-acutely-symptomatic-carotid-disease
#20
Hernan A Bazan, Yan Lu, Bokkyoo Jun, Zhide Fang, T Cooper Woods, Song Hong
BACKGROUND: Efficient biomarkers for early prediction and diagnosis of an acutely symptomatic carotid plaque rupture event are currently lacking, impairing the ability to diagnose and treat patients with an acute plaque rupture events in a timely fashion. Resolvins are endogenous inflammation-resolving lipid mediators that are induced by inflammatory insults. We hypothesized that resolvin and other lipid profiles in sera likely mark the process towards plaque rupture. METHODS: Circulating lipids associated with plaque rupture events were quantitatively profiled via targeted mediator-lipidomics using ultraperformance liquid chromatography tandem mass spectrometry in patients with acutely symptomatic and asymptomatic carotid disease...
October 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
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