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plasmacytoid dendritic cells

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https://www.readbyqxmd.com/read/29466691/role-of-production-of-type-i-interferons-by-b-cells-in-the-mechanisms-and-pathogenesis-of-systemic-lupus-erythematosus
#1
Jennie A Hamilton, Hui-Chen Hsu, John D Mountz
Type I interferons (IFNs) have a prominent role in many aspects of normal innate and adaptive immunity and autoimmunity. However, cell-type specific information about type I IFN expression and autocrine/paracrine signaling is sparse and mostly focused on non-lymphocyte and non-immune cell populations. A major function of B cells is cytokine production, but surprisingly, type I IFN production by B cells in systemic lupus erythematosus (SLE) has not been thoroughly investigated. This is due, in part, to the established view that plasmacytoid dendritic cells (pDCs) are the primary source of pathogenic type I IFN in lupus...
January 2018: Discovery Medicine
https://www.readbyqxmd.com/read/29463744/mhc-mismatched-mixed-chimerism-restores-peripheral-tolerance-of-noncross-reactive-autoreactive-t-cells-in-nod-mice
#2
Mingfeng Zhang, Jeremy J Racine, Qing Lin, Yuqing Liu, Shanshan Tang, Qi Qin, Tong Qi, Arthur D Riggs, Defu Zeng
Autoimmune type 1 diabetes (T1D) and other autoimmune diseases are associated with particular MHC haplotypes and expansion of autoreactive T cells. Induction of MHC-mismatched but not -matched mixed chimerism by hematopoietic cell transplantation effectively reverses autoimmunity in diabetic nonobese diabetic (NOD) mice, even those with established diabetes. As expected, MHC-mismatched mixed chimerism mediates deletion in the thymus of host-type autoreactive T cells that have T-cell receptor (TCR) recognizing (cross-reacting with) donor-type antigen presenting cells (APCs), which have come to reside in the thymus...
February 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29456743/il-10-in-the-microenvironment-of-hnscc-inhibits-the-cpg-odn-induced-ifn-%C3%AE-secretion-of-pdcs
#3
Karl-Ludwig Bruchhage, Sabrina Heinrichs, Barbara Wollenberg, Ralph Pries
It has been shown that head and neck squamous cell carcinoma (HNSCC) are infiltrated by plasmacytoid dendritic cells (pDCs). The HNSCC TH2 biased microenvironment leads to strong alterations of the cellular functions of pDC and thus impairs the initiation and function of adequate immune responses. In this work we comprehensively analyzed the capacity of CpG-oligonucleotides to activate interferon (IFN)-α secretion of human pDC in the presence of HNSCC. IFN-α secretion was measured using the ELISA Technique...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29455234/blastic-plasmacytoid-dendritic-cell-neoplasm-update-on-therapy-especially-novel-agents
#4
REVIEW
Shunan Wang, Xingtong Wang, Mingsuo Liu, Ou Bai
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematopoietic malignancy mainly affecting elderly patients. Most patients present with asymptomatic skin lesions as the first symptom and has a high frequency of bone marrow involvement. BPDCN is typically characterized by CD4+ and CD 56+ co-expression without common lymphoid or myeloid lineage markers. There is no consensus on the optimal therapeutic strategy for BPDCN. It is highly responsive to chemotherapy but the median event-free survival is very short...
February 17, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29453437/enhancement-of-immunomodulative-effect-of-lactic-acid-bacteria-on-plasmacytoid-dendritic-cells-with-sucrose-palmitate
#5
Masaya Kanayama, Yukiko Kato, Toshikazu Tsuji, Yuki Konoeda, Akiko Hashimoto, Osamu Kanauchi, Toshio Fujii, Daisuke Fujiwara
Plasmacytoid dendritic cells (pDCs) play a key role in the immune response against viruses. In addition, recent research has suggested that pDCs possess direct and indirect tumoricidal activities. We previously found that a lactic acid bacteria strain, Lactococcus lactis JCM 5805 (LC-Plasma), stimulated pDCs and prevented viral infection in mouse and human studies. Meanwhile, emulsifiers have recently been highlighted as candidate adjuvants for some viral vaccines and cancer immunotherapies. In this study, we discovered some specific emulsifiers, mainly consisting of sucrose fatty acid esters, that drastically enhance the potency of LC-Plasma to activate pDCs in vitro...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29444460/plasmacytoid-pre-dendritic-cells-pdc-from-molecular-pathways-to-function-and-disease-association
#6
REVIEW
Solana Alculumbre, Salvatore Raieli, Caroline Hoffmann, Rabie Chelbi, François-Xavier Danlos, Vassili Soumelis
Plasmacytoid pre-dendritic cells (pDC) are a specialized DC population with a great potential to produce large amounts of type I interferon (IFN). pDC are involved in the initiation of antiviral immune responses through their interaction with innate and adaptive immune cell populations. In a context-dependent manner, pDC activation can induce their differentiation into mature DC able to induce both T cell activation or tolerance. In this review, we described pDC functions during immune responses and their implication in the clearance or pathogenicity of human diseases during infection, autoimmunity, allergy and cancer...
February 11, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29439958/interaction-between-tlr9-cpg-odns-and-hbv-virions-leads-to-entry-inhibition-in-hepatocytes-and-reduction-of-ifn%C3%AE-production-by-pdc
#7
Ludovic Aillot, Marc Bonnin, Malika Ait-Goughoulte, Nathalie Bendriss-Vermare, Sarah Maadadi, Laura Dimier, Mina Subic, Caroline Scholtes, Isabel Najera, Fabien Zoulim, Julie Lucifora, David Durantel
We previously reported that TLR9 CpG-oligonucleotides could inhibit the establishment of HBV infections in hepatocytes. Our aim was to uncover the underlying mechanisms of this inhibition. HepaRG, RPMI-B lymphoblastoma and primary plasmacytoid dendritic cells exposed to HBV and TLR9 ligands/agonists in various configurations were used. We observed an inhibition of HBV infection upon TLR9 stimulations only when agonist was applied during inoculation. This inhibition was independent of IL6/IP10 production as well as of TLR9 expression in hepatocytes...
February 12, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29436012/skin-lesions-serve-as-clues-to-relapse-of-pediatric-blastic-plasmacytoid-dendritic-cell-neoplasm
#8
Sean Dreyer, Suzanne Mednik, Allison Truong, Scott Worswick, Philip Scumpia, Daniel Neill, Swati Kannan, Marcia Hogeling
A 10-year-old girl with a history of blastic plasmacytoid dendritic cell neoplasm, a rare malignancy in children, presented with recurrent skin eruptions beginning while on maintenance chemotherapy, including mildly pruritic skin-colored plaques, tender indurated nodules, and violaceous bound-down plaques. This case highlights an unusual presentation of relapsed blastic plasmacytoid dendritic cell neoplasm on chemotherapy, with skin lesions providing important clues to the progression of systemic disease.
February 13, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29431693/an-antigen-free-plasmacytoid-dendritic-cell-targeting-immunotherapy-to-bolster-memory-cd8-t-cells-in-nonhuman-primates
#9
Yuji Masuta, Takuya Yamamoto, Yayoi Natsume-Kitatani, Tomohiro Kanuma, Eiko Moriishi, Kouji Kobiyama, Kenji Mizuguchi, Yasuhiro Yasutomi, Ken J Ishii
The priming, boosting, and restoration of memory cytotoxic CD8+ T lymphocytes by vaccination or immunotherapy in vivo is an area of active research. Particularly, nucleic acid-based compounds have attracted attention due to their ability to elicit strong Ag-specific CTL responses as a vaccine adjuvant. Nucleic acid-based compounds have been shown to act as anticancer monotherapeutic agents even without coadministration of cancer Ag(s); however, so far they have lacked efficacy in clinical trials. We recently developed a second-generation TLR9 agonist, a humanized CpG DNA (K3) complexed with schizophyllan (SPG), K3-SPG, a nonagonistic Dectin-1 ligand...
February 5, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29430717/cutaneous-infiltration-of-plasmacytoid-dendritic-cells-and-t-regulatory-cells-in-skin-lesions-of-polymorphic-light-eruption
#10
M T Rossi, M Arisi, S Lonardi, L Lorenzi, M Ungari, F Serana, M Fusano, E Moggio, P G Calzavara-Pinton, M Venturini
BACKGROUND: Polymorphic light eruption (PLE) is the most common autoimmune photodermatosis. Plasmacytoid dendritic cells (PDCs) are important mediators of innate anti-microbial immunity involved in the pathogenesis of many inflammatory skin diseases. In addition to PDCs, regulatory T cells (Tregs) are involved in controlling inflammation and adaptative immunity in skin by their immunosoppressive capacity. OBJECTIVE: The aim of the present study was to investigate the presence of PDCs and Tregs in photoexposed skin from PLE compared to healthy skin...
February 11, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29429903/increased-infiltration-of-cd11-c-cd123-dendritic-cell-subsets-and-upregulation-of-tlr-ifn-%C3%AE-signaling-participate-in-pathogenesis-of-oral-lichen-planus
#11
Yufeng Wang, Shu Shang, Qianqian Sun, Junjun Chen, Guanhuan Du, Hong Nie, Xiaozhe Han, Guoyao Tang
OBJECTIVE: Investigation of dendritic cell (DC) subsets and expression patterns of Toll-like receptors (TLRs) was conducted to understand the pathogenesis in oral lichen planus (OLP). STUDY DESIGN: Blood, OLP lesion, and control samples were collected. Four DC subsets (CD11c + CD123 - myeloid DC1 [mDC1], CD141 + mDC2, CD11c - CD123 + plasmacytoid DC [pDC], and CD1a + CD207 + Langerhans cells [LC]) were investigated via flow cytometry (FCM) and immunohistochemical staining...
December 18, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29425937/ige-in-lupus-pathogenesis-friends-or-foes
#12
REVIEW
Jean-François Augusto, Marie-Elise Truchetet, Nicolas Charles, Patrick Blanco, Christophe Richez
Systemic lupus erythematosus (SLE) is a complex autoimmune disease involving multiple immunological pathways. Recently, several studies have suggested an implication of Immunoglobulin E (IgE) in the pathophysiology of SLE. In the Lyn-/- and FcγIIB-/-.Yaa lupus mouse models, autoreactive IgE activate basophils, and promote a Th2 environment with, subsequently, production of autoantibodies by plasma cells. Autoreactive IgE has been also shown to play a role in the activation of human plasmacytoid dendritic cells (pDCs), in synergy with IgG, which results in an increase of interferon-alpha (IFN-α) production...
February 6, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29425831/gs-9620-inhibits-enterovirus-71-replication-mainly-through-the-nf-%C3%AE%C2%BAb-and-pi3k-akt-signaling-pathways
#13
Qian Zhang, Binbin Zhao, Xin Chen, Nan Song, Jing Wu, Guangchao Li, Pin Yu, Yunlin Han, Jiangning Liu, Chuan Qin
Human enterovirus 71 (EV71) is the second most common cause of hand, foot, and mouth disease (HFMD), which can occur as a severe epidemic especially among children under 5-years old. New and improved treatment strategies to control EV71 infection are therefore urgently required. The heterocyclic compound GS-9620, a potent and selective agonist of Toll-like receptor 7 (TLR7), has been reported to activate plasmacytoid dendritic cells (pDCs), and suppress HBV as well as HIV replication. In this study, we indicated that GS-9620 also could inhibit EV71 replication in the mouse model of EV71 infection...
February 6, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29424411/-blastic-plasmacytoid-dendritic-cell-neoplasm-report-of-three-cases
#14
Alejandro Avilés-Salas, Myrna Candelaria, Mayra Ponce, Abraham Cañavera-Constantino, Sebastián Burgos
Blastic plasmacytoid dendritic cell neoplasm is a rare hematological malignancy derived from immature plasmacytoid dendritic cells. The tumor cells have an immature blastic appearance, and diagnosis is based on the expression of CD4, CD56 y CD123 in the absence of other lymphoid, natural killer, or myeloid antigens. The majority of affected individuals are older people with a mean age of 66 years. Male to female ratio is approximately 3:1. Common presentation includes cutaneous lesions followed by tumor dissemination...
September 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29419438/clonal-evolution-in-the-transition-from-cutaneous-disease-to-acute-leukaemia-suggested-by-liquid-biopsy-in-blastic-plasmacytoid-dendritic-cell-neoplasm
#15
Eleni Ladikou, Barbara Ottolini, Nadia Nawaz, Rebecca L Allchin, Daniel Payne, Hebah Ali, Teresa Marafioti, Jacqui Shaw, Matthew J Ahearne, Simon D Wagner
No abstract text is available yet for this article.
February 1, 2018: Haematologica
https://www.readbyqxmd.com/read/29417284/biologic-meshes-and-synthetic-meshes-in-cancer-patients-a-double-edged-sword-differences-in-production-of-il-6-and-il-12-caused-by-acellular-dermal-matrices-in-human-immune-cells
#16
Maria Margarete Karsten, Sabine Enders, Julia Knabl, Verena Kirn, Peter Düwell, Brigitte Rack, Jens-Uwe Blohmer, Doris Mayr, Darius Dian
PURPOSE: In 2005, Breuing et al. first described the use of acellular dermal matrices (ADMs) in breast cancer patients. ADMs are assumed to be safe to use in an oncologic setting, but data from controlled studies are still needed. Here, we investigate the effects of ADMs on the production of interleukin (IL)-6 and IL-12, key regulators of immune suppression and activation. METHODS: Strattice (ST), CollaMend (CM), and Biodesign (BD) biologic meshes and TiLoop, a synthetic mesh (TL), were used in this study...
February 7, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29415975/detection-of-minimal-bone-marrow-involvement-of-blastic-plasmacytoid-dendritic-cell-neoplastic-cells-cd303-immunostaining-as-a-diagnostic-tool
#17
Rintaro Ohe, Naing Ye Aung, Yosuke Shiono, Aya Utsunomiya, Takanobu Kabasawa, Nobuyuki Tamazawa, Yuka Tamura, Tomoya Kato, Akane Yamada, Shin Hasegawa, Keiko Aizawa, Kyoko Inokura, Satoshi Ito, Tomomi Toubai, Yuichi Kato, Takahiko Tsunoda, Kosuke Onami, Tamio Suzuki, Kenichi Ishizawa, Mitsunori Yamakawa
Blastic plasmacytoid dendritic cell (pDC) neoplasm (BPDCN) is a relatively rare hematological malignancy with significantly complex clinicopathological features that are still unclear. This study aimed to analyze the clinicopathological data of BPDCN and evaluate immunohistochemical detection of minimal bone marrow (BM) involvement. In this study, we examined skin and BM lesions from 6 patients with BPDCN. Neoplastic cells tested positive for CD303 (polyclonal, 100%; monoclonal, 40%) in the skin lesions and for CD303 (polyclonal, 100%; monoclonal, 67%) in the BM clots...
February 8, 2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29414652/administration-of-lactococcus-lactis-strain-plasma-induces-maturation-of-plasmacytoid-dendritic-cells-and-protection-from-rotavirus-infection-in-suckling-mice
#18
Kenta Jounai, Tetsu Sugimura, Yuji Morita, Konomi Ohshio, Daisuke Fujiwara
Lactococcus lactis subsp. lactis JCM 5805 (LC-Plasma) is a strain of lactic acid bacteria (LAB) that activates murine and human plasmacytoid dendritic cells (pDCs) to express interferons (IFNs). Oral administration of LC-Plasma drastically decreased fatality levels caused by parainfluenza virus infection in a murine model. In this study, we investigated the anti-viral effects of oral administration of LC-Plasma using a suckling mouse model of rhesus rotavirus (RV) infection. LC-Plasma-fed mice showed improvement in retardation of body weight gain, fecal scores, and a reduction in RV titer in the feces when compared to control mice...
January 27, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29411884/blastic-plasmacytoid-dendritic-cell-neoplasm-with-unusual-morphology-myc-rearrangement-and-tet2-and-dnmt3a-mutations
#19
Habibe Kurt, Joseph D Khoury, L Jeffrey Medeiros, Yang O Huh
No abstract text is available yet for this article.
February 7, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29407586/8q24-myc-rearrangement-is-a-recurrent-cytogenetic-abnormality-in-blastic-plasmacytoid-dendritic-cell-neoplasms
#20
Prajwal C Boddu, Sa A Wang, Naveen Pemmaraju, Zhenya Tang, Shimin Hu, Shaoying Li, Jie Xu, L Jeffrey Medeiros, Guilin Tang
8q24/MYC rearrangements resulting in MYC overexpression occur most frequently in lymphoid neoplasms. MYC rearrangements rarely have been described in blastic plasmacytoid dendritic cell neoplasm (BPDCN). Over an 8-year period in our hospital, 5 of 41 (12%) patients with BPDCN were shown 8q24/MYC rearrangements, including 2 with t(6;8)(p21;q24), 1 with t(8;14)(q24;q32), 1 with t(X;8)(q24;q24), and 1 with t(3;8)(p25;q24). 8q24/MYC rearrangement was present in the stemline in 4 patients and in the sideline in one; the latter was a patient with primary myelofibrosis who then developed BPDCN...
February 2, 2018: Leukemia Research
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