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plasmacytoid dendritic cells

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https://www.readbyqxmd.com/read/28818792/regulation-of-type-i-interferon-responses-by-mitochondria-derived-reactive-oxygen-species-in-plasmacytoid-dendritic-cells
#1
Zsofia Agod, Tünde Fekete, Marietta M Budai, Aliz Varga, Attila Szabo, Hyelim Moon, Istvan Boldogh, Tamas Biro, Arpad Lanyi, Attila Bacsi, Kitti Pazmandi
Mitochondrial reactive oxygen species (mtROS) generated continuously under physiological conditions have recently emerged as critical players in the regulation of immune signaling pathways. In this study we have investigated the regulation of antiviral signaling by increased mtROS production in plasmacytoid dendritic cells (pDCs), which, as major producers of type I interferons (IFN), are the key coordinators of antiviral immunity. The early phase of type I IFN production in pDCs is mediated by endosomal Toll-like receptors (TLRs), whereas the late phase of IFN response can also be triggered by cytosolic retinoic acid-inducible gene-I (RIG-I), expression of which is induced upon TLR stimulation...
July 29, 2017: Redox Biology
https://www.readbyqxmd.com/read/28810298/-blastic-plasmacytoid-dendritic-cell-neoplasm-a-clinicopathologic-analysis-of-6-cases
#2
H J Huang, X Y Chen, Z Y Zheng
No abstract text is available yet for this article.
August 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28798071/bortezomib-as-a-new-therapeutic-approach-for-blastic-plasmacytoid-dendritic-cell-neoplasm
#3
Laure Philippe, Adam Ceroi, Elodie Bôle-Richard, Alizée Jenvrin, Sabeha Biichle, Sophie Perrin, Samuel Limat, Francis Bonnefoy, Eric Deconinck, Philippe Saas, Francine Garnache-Ottou, Fanny Angelot-Delettre
Blastic plasmacytoid dendritic cell neoplasm is an aggressive hematological malignancy with a poor prognosis. No consensus for optimal treatment modalities is available today. Targeting the NF-κB pathway is considered as a promising approach since blastic plasmacytoid dendritic cell neoplasm have been reported to exhibit a constitutive activation of the NF-κB pathway. Moreover, NF-κB inhibition in blastic plasmacytoid dendritic cell neoplasm cell lines using either an experimental specific inhibitor JSH23 or the clinical drug bortezomib interferes in vitro with leukemic cell proliferation and survival...
August 10, 2017: Haematologica
https://www.readbyqxmd.com/read/28795410/clinicopathological-analysis-of-46-cases-with-cd4-and-or-cd56-immature-hematolymphoid-malignancy-reappraisal-of-blastic-plasmacytoid-dendritic-cell-and-related-neoplasms
#4
Yuka Suzuki, Seiichi Kato, Kei Kohno, Akira Satou, Ahmed E Eladl, Naoko Asano, Michihiro Kono, Yuichi Kato, Masafumi Taniwaki, Masashi Akiyama, Shigeo Nakamura
AIMS: Here we aimed to investigate the clinicopathological features of CD4+ and/or CD56+ immature hematolymphoid malignancy (iHLM), including blastic plasmacytoid dendritic cell neoplasm (BPDCN). METHODS AND RESULTS: We analysed the clinicopathological features of 46 patients consecutively diagnosed with CD4+/CD56+ iHLM. These cases were categorized into three groups based on their immunohistochemical expression of three plasmacytoid dendritic cell (pDC) markers (CD123, CD303, and TCL1): cutaneous BPDCN (n = 35), non-cutaneous BPDCN (n = 6), and non-BPDCN-type CD56+ neoplasms (n = 5)...
August 10, 2017: Histopathology
https://www.readbyqxmd.com/read/28795194/-treatment-of-rare-cutaneous-t%C3%A2-cell-lymphoma-and-blastic-plasmacytoid-dendritic-cell-neoplasm
#5
REVIEW
U Wehkamp, M Weichenthal
Among the group of primary cutaneous lymphomas several subtypes have very low incidence rates. Based on the revision of the WHO classification for lymphoid neoplasms (2016), an overview of rare cutaneous T‑cell lymphoma (CTCL) subtypes is given and therapeutic approaches are detailed. The prognosis of the different subtypes is highly variable underlining the importance of adequate stage and subtype adapted treatment. In cases of indolent subtypes topical treatment, e. g. topical corticosteroids or UV phototherapy are often sufficient...
August 9, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28791025/the-ido-ahr-axis-controls-th17-treg-immunity-in-a-pulmonary-model-of-fungal-infection
#6
Eliseu Frank de Araújo, Claudia Feriotti, Nayane Alves de Lima Galdino, Nycolas Willian Preite, Vera Lúcia Garcia Calich, Flávio Vieira Loures
In infectious diseases, the enzyme indoleamine 2,3 dioxygenase-1 (IDO1) that catalyzes the tryptophan (Trp) degradation along the kynurenines (Kyn) pathway has two main functions, the control of pathogen growth by reducing available Trp and immune regulation mediated by the Kyn-mediated expansion of regulatory T (Treg) cells via aryl hydrocarbon receptor (AhR). In pulmonary paracoccidioidomycosis (PCM) caused by the dimorphic fungus Paracoccidioides brasiliensis, IDO1 was shown to control the disease severity of both resistant and susceptible mice to the infection; however, only in resistant mice, IDO1 is induced by TGF-β signaling that confers a stable tolerogenic phenotype to dendritic cells (DCs)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28783692/human-lymphoid-organ-dendritic-cell-identity-is-predominantly-dictated-by-ontogeny-not-tissue-microenvironment
#7
Gordon F Heidkamp, Jil Sander, Christian H K Lehmann, Lukas Heger, Nathalie Eissing, Anna Baranska, Jennifer J Lühr, Alana Hoffmann, Katharina C Reimer, Anja Lux, Stephan Söder, Arndt Hartmann, Johannes Zenk, Thomas Ulas, Naomi McGovern, Christoph Alexiou, Bernd Spriewald, Andreas Mackensen, Gerold Schuler, Burkhard Schauf, Anja Forster, Roland Repp, Peter A Fasching, Ariawan Purbojo, Robert Cesnjevar, Evelyn Ullrich, Florent Ginhoux, Andreas Schlitzer, Falk Nimmerjahn, Joachim L Schultze, Diana Dudziak
In mice, conventional and plasmacytoid dendritic cells (DCs) derive from separate hematopoietic precursors before they migrate to peripheral tissues. Moreover, two classes of conventional DCs (cDC1 and cDC2 DCs) and one class of plasmacytoid DCs (pDCs) have been shown to be transcriptionally and functionally distinct entities. In humans, these three DC subtypes can be identified using the cell surface markers CD1c (cDC2), CD141 (cDC1), and CD303 (pDCs), albeit it remains elusive whether DC functionality is mainly determined by ontogeny or the tissue microenvironment...
December 16, 2016: Science Immunology
https://www.readbyqxmd.com/read/28777892/therapeutical-modulation-of-plasmacytoid-dendritic-cells-in-experimental-arthritis
#8
Ramzi Nehmar, Ghada Alsaleh, Benjamin Voisin, Vincent Flacher, Alexandre Mariotte, Victoria Saferding, Antonia Puchner, Birgit Niederreiter, Thierry Vandamme, Gernot Schabbauer, Philippe Kastner, Susan Chan, Peggy Kirstetter, Martin Holcmann, Christopher Mueller, Jean Sibilia, Seiamak Bahram, Stephan Blüml, Philippe Georgel
OBJECTIVES: The role of plasmacytoid dendritic cells (pDCs) and type I Interferons in rheumatoid arthritis (RA) remains controversial. To explore their contribution to RA pathogenesis, we induced experimental arthritis in various animal models of pDC depletion. We also monitored the effect of localized pDC recruitment and activation on joint inflammation and bone damage. METHODS: Experimental arthritis in mice was obtained by K/BxN serum transfer, heterologous collagen immunization (CIA) or in hTNF-transgenics...
August 4, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28777803/gm-csf-in-murine-psoriasiform-dermatitis-redundant-and-pathogenic-roles-uncovered-by-antibody-induced-neutralization-and-genetic-deficiency
#9
Tatjana Scholz, Andreas Weigert, Bernhard Brüne, Christian D Sadik, Beate Böhm, Harald Burkhardt
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pleiotropic, Th17-derived cytokine thought to critically contribute to the pathogenesis of diverse autoimmune diseases, including rheumatoid arthritis and psoriasis. Treatment with monoclonal antibodies that block GM-CSF activity is associated with favorable therapeutic effects in patients with rheumatoid arthritis. We evaluated the role of GM-CSF as a potential target for therapeutic interference in psoriasis using a combined pharmacologic and genetic approach and the mouse model of imiquimod-induced psoriasiform dermatitis (IMQPD)...
2017: PloS One
https://www.readbyqxmd.com/read/28774715/dendritic-cell-recruitment-and-activation-in-autoimmunity
#10
REVIEW
Silvano Sozzani, Annalisa Del Prete, Daniela Bosisio
Dendritic cells (DCs) are professional antigen presenting cells displaying the unique capability to activate naïve T cells. DCs react to pathogen encounter also by the production of mediators of inflammation, including pro-inflammatory cytokines. Because of this complex role, any imbalance in DC function reflects into defective or exaggerated immune response and tissue damage. DCs comprise two main subsets, namely conventional or classical DCs (cDCs), that are dedicated antigen presenting cells, and plasmacytoid DCs (pDCs), that respond to nucleic acids by releasing high amounts of type I interferons (IFNs)...
July 31, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28769925/pharmacodynamic-monitoring-of-ro5459072-a-small-molecule-inhibitor-of-cathepsin-s
#11
Michel Theron, Darren Bentley, Sandra Nagel, Marianne Manchester, Michael Gerg, Thomas Schindler, Ana Silva, Barbara Ecabert, Priscila Teixeira, Camille Perret, Bernhard Reis
Major histocompatibility complex class II (MHCII)-restricted antigen priming of CD4(+) T cells is both involved in adaptive immune responses and the pathogenesis of autoimmune diseases. Degradation of invariant chain Ii, a protein that prevents premature peptide loading, is a prerequisite for nascent MHCII-peptide complex formation. A key proteolytic step in this process is mediated by cathepsin S. Inhibition of this cysteine protease is known to result in the intracellular accumulation of Lip10 in B cells...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28768858/human-metapneumovirus-m2-2-protein-acts-as-a-negative-regulator-of-alpha-interferon-production-by-plasmacytoid-dendritic-cells
#12
Yoshinori Kitagawa, Madoka Sakai, Mariko Funayama, Masae Itoh, Bin Gotoh
Human metapneumovirus (HMPV) has the ability to inhibit TLR7- and TLR9-dependent alpha interferon (IFN-α) production by plasmacytoid dendritic cells (pDCs). However the inhibition mechanism remains largely unknown. To identify viral proteins responsible for this inhibition, we performed a screening of HMPV open reading frames (ORFs) for their abilities to block TLR7/9-dependent signaling reconstituted in HEK293T cells by transfection with MyD88, TRAF6, IKKα, and IRF7. This screening demonstrated that the M2-2 protein was the most potent inhibitor of TLR7/9-dependent IFN-α induction...
August 2, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28761306/blastic-plasmacytoid-dendritic-cell-neoplasm-presenting-as-erythematous-nodules-with-gallbladder-involvement
#13
Sook Hyun Kong, Seok Hyun Han, Ho Seok Suh, Yu Sung Choi
No abstract text is available yet for this article.
August 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28759657/hiv-1-infection-depletes-human-cd34-cd38-hematopoietic-progenitor-cells-via-pdc-dependent-mechanisms
#14
Guangming Li, Juanjuan Zhao, Liang Cheng, Qi Jiang, Sheng Kan, Enqiang Qin, Bo Tu, Xin Zhang, Liguo Zhang, Lishan Su, Zheng Zhang
Chronic human immunodeficiency virus-1 (HIV-1) infection in patients leads to multi-lineage hematopoietic abnormalities or pancytopenia. The deficiency in hematopoietic progenitor cells (HPCs) induced by HIV-1 infection has been proposed, but the relevant mechanisms are poorly understood. We report here that both human CD34+CD38- early and CD34+CD38+ intermediate HPCs were maintained in the bone marrow (BM) of humanized mice. Chronic HIV-1 infection preferentially depleted CD34+CD38- early HPCs in the BM and reduced their proliferation potential in vivo in both HIV-1-infected patients and humanized mice, while CD34+CD38+ intermediate HSCs were relatively unaffected...
July 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28755918/indeterminate-dendritic-cell-tumor-in-thoracic-spine-a-case-report-and-review-of-literature
#15
Sze Kiat Tan, Lee Onn Chieng, Karthik Madhavan, Andrew Rosenberg, Ian Cote
Indeterminate dendritic cell tumor (IDCT) is an extremely rare hematological disorder with poorly understood pathogenesis. Occasionally encountered by hematologists, unusual presentations of IDCT have never been reported in the spine literature. The authors report a case of a 51-year-old man who presented with progressively worsening axial thoracic back pain radiating to his sides for three months. MRI revealed a large 3-cm enhancing mass at the T9 vertebral body with an exophytic component causing significant canal stenosis...
July 26, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28752938/dendritic-cells-in-hepatitis-and-liver-transplantation
#16
Radika Soysa, Xia Wu, I Nicholas Crispe
Dendritic cells (DCs) play a key role in innate immune responses, and are also the most effective cells for the activation of T cell immunity. They acquire antigen and process it, then display in on the cell surface bound in a non-covalent complex with HLA molecules of class I (HLA-A, B, C) and class II (HLA-DR). These cells are subdivided into three main subsets, two called myeloid or classical DCs of types 1 and 2, and one called plasmacytoid. The myeloid DCs process and present antigen, while the plasmacytoid DCs also strongly respond to viral signals by secreting Type 1 Interferon...
July 28, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28752676/fine-needle-aspiration-findings-of-a-rare-hematopoietic-neoplasm-presenting-as-obstructive-jaundice
#17
Jessica Tracht, Ali M Ahmed, Frida Rosenblum Donath
A 51-year-old female who presented with obstructive jaundice was found to have masses in the pancreatic head and tail as well as suspicious liver and periaortic masses on imaging. Aspiration cytology of the pancreatic tail mass showed abundant large single cells with vacuolated eosinophilic cytoplasm, marked nuclear pleomorphism, large bizarre irregular nuclei, binucleation, and prominent nucleoli. Numerous cells also showed intracytoplasmic black to brown pigmentation. A cell block was obtained and extensive immunohistochemical staining was performed...
July 27, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28752118/localized-skin-limited-blastic-plasmacytoid-dendritic-cell-neoplasm-a-subset-with-possible-durable-remission-without-transplantation
#18
Iris Amitay-Laish, Uma Sundram, Richard T Hoppe, Emmilia Hodak, Bruno C Medeiros, Youn H Kim
No abstract text is available yet for this article.
July 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28751556/arid1a-mutation-in-blastic-plasmacytoid-dendritic-cell-neoplasm
#19
Lei Wang, Min Yang, Xiang Zhang, Chunmei Yang, Xin Huang, Zhaoming Wang, Jie Jin
No abstract text is available yet for this article.
July 27, 2017: Haematologica
https://www.readbyqxmd.com/read/28744288/naltrexone-inhibits-il-6-and-tnf%C3%AE-production-in-human-immune-cell-subsets-following-stimulation-with-ligands-for-intracellular-toll-like-receptors
#20
Rachel Cant, Angus G Dalgleish, Rachel L Allen
The opioid antagonist naltrexone hydrochloride has been suggested to be a potential therapy at low dosage for multiple inflammatory conditions and cancers. Little is known about the immune-modulating effects of naltrexone, but an effect on the activity of toll-like receptor 4 (TLR4) has been reported. We analyzed the effects of naltrexone hydrochloride on IL-6 secretion by peripheral blood mononuclear cells (PBMC) in vitro following stimulation with ligands for TLR4 and for the intracellular receptors TLR7, TLR8, and TLR9...
2017: Frontiers in Immunology
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