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plasmacytoid dendritic cells

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https://www.readbyqxmd.com/read/27915109/decreased-myeloid-dendritic-cells-indicate-a-poor-prognosis-of-severe-fever-with-thrombocytopenia-syndrome-patients
#1
Wenjing Zhang, Mengmeng Li, Shue Xiong, Hua Wang, Yan Xiong, Mingyue Li, Mengji Lu, DongliangYang, Cheng Peng, Xin Zheng
OBJECTIVES: Severe fever with thrombocytopenia syndrome (SFTS) is a newly emerging infectious disease caused by a novel Bunyavirus in which host immune system suppression is thought to be crucial in the development of disease. The study is designed to study the frequencies and activation status of dendritic cells(DCs) at different stages of SFTS and its association with the disease severity. METHODS: All confirmed 115 SFTS patients were recruited from the Wuhan Union Hospital in 2015 and routine laboratory parameters were collected...
November 30, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27913457/treatment-of-blastic-plasmacytoid-dendritic-cell-neoplasm
#2
Jill M Sullivan, David A Rizzieri
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare myeloid malignancy with no defined standard of care. BPDCN presents most commonly with skin lesions with or without extramedullary organ involvement before leukemic dissemination. As a result of its clinical ambiguity, differentiating BPDCN from benign skin lesions or those of acute myeloid leukemia with leukemia cutis is challenging. BPDCN is most easily defined by the phenotype CD4(+)CD56(+)CD123(+)lineage(-)MPO(-), although many patients will present with variable expression of CD4, CD56, or alternate plasmacytoid markers, which compounds the difficulty in differentiating BPDCN from other myeloid or lymphoid malignancies...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27913389/bet-inhibitors-target-blastic-plasmacytoid-dendritic-cell-neoplasms
#3
(no author information available yet)
Blastic plasmacytoid dendritic cell neoplasms (BPDCN) depend on a TCF4/BRD4 transcriptional program.
December 2, 2016: Cancer Discovery
https://www.readbyqxmd.com/read/27895398/dysregulation-of-innate-immunity-in-ulcerative-colitis-patients-who-fail-anti-tumor-necrosis-factor-therapy
#4
Angela C Baird, Dominic Mallon, Graham Radford-Smith, Julien Boyer, Thierry Piche, Susan L Prescott, Ian C Lawrance, Meri K Tulic
AIM: To study the innate immune function in ulcerative colitis (UC) patients who fail to respond to anti-tumor necrosis factor (TNF) therapy. METHODS: Effects of anti-TNF therapy, inflammation and medications on innate immune function were assessed by measuring peripheral blood mononuclear cell (PBMC) cytokine expression from 18 inflammatory bowel disease patients pre- and 3 mo post-anti-TNF therapy. Toll-like receptor (TLR) expression and cytokine production post TLR stimulation was assessed in UC "responders" (n = 12) and "non-responders" (n = 12) and compared to healthy controls (n = 12)...
November 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27895179/thymic-dendritic-cell-subsets-display-distinct-efficiencies-and-mechanisms-of-intercellular-mhc-transfer
#5
Charles J Kroger, Nicholas A Spidale, Bo Wang, Roland Tisch
Thymic dendritic cells (DC) delete self-antigen-specific thymocytes, and drive development of Foxp3-expressing immunoregulatory T cells. Unlike medullary thymic epithelial cells, which express and present peripheral self-antigen, DC must acquire self-antigen to mediate thymic negative selection. One such mechanism entails the transfer of surface MHC-self peptide complexes from medullary thymic epithelial cells to thymic DC. Despite the importance of thymic DC cross-dressing in negative selection, the factors that regulate the process and the capacity of different thymic DC subsets to acquire MHC and stimulate thymocytes are poorly understood...
November 28, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27892478/continuous-single-cell-imaging-reveals-sequential-steps-of-plasmacytoid-dendritic-cell-development-from-common-dendritic-cell-progenitors
#6
Ezgi Dursun, Max Endele, Andrea Musumeci, Henrik Failmezger, Shu-Hung Wang, Achim Tresch, Timm Schroeder, Anne B Krug
Functionally distinct plasmacytoid and conventional dendritic cells (pDC and cDC) shape innate and adaptive immunity. They are derived from common dendritic cell progenitors (CDPs) in the murine bone marrow, which give rise to CD11c(+) MHCII(-) precursors with early commitment to DC subpopulations. In this study, we dissect pDC development from CDP into an ordered sequence of differentiation events by monitoring the expression of CD11c, MHC class II, Siglec H and CCR9 in CDP cultures by continuous single cell imaging and tracking...
November 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27891600/human-pdcs-display-sex-specific-differences-in-type-i-interferon-subtypes-and-interferon-%C3%AE-%C3%AE-receptor-expression
#7
Susanne Ziegler, Claudia Beisel, Kathrin Sutter, Morgane Griesbeck, Heike Hildebrandt, Sven Hagen, Ulf Dittmer, Marcus Altfeld
The outcomes of many diseases differ between women and men, with women experiencing a higher incidence and more severe pathogenesis of autoimmune and some infectious diseases. It has been suggested that this is partially due to activation of plasmacytoid dendritic cells (pDCs), the main producers of interferon (IFN)-α, in response to toll-like receptor (TLR) 7 stimulation. We investigated the induction of type I IFN (IFN-I) subtypes upon TLR7 stimulation on isolated pDCs. Our data revealed a sex-specific differential expression of IFN-Is, with pDCs from females showing a significantly higher mRNA expression of all 13 IFNα-subtypes...
November 28, 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/27870663/dendritic-cell-subset-expression-in-severe-chronic-rhinosinusitis-with-nasal-polyps
#8
Claudina Perez-Novo, Rogério Pezato
PURPOSE OF REVIEW: Two main pillars are implicated in nasal polyposis development: a severe imbalance in immunomodulation and a mechanical dysfunction because of an abnormal remodeling process. Dendritic cells play a crucial role in the link between innate and adaptive immune response and orchestrating the T-cell response and are implicated in the severe inflammatory process found in nasal polypoid tissue. This review summarizes the existent knowledge about dendritic cells in nasal polyposis...
November 18, 2016: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27865391/modulation-of-dendritic-cell-and-monocyte-subsets-in-tuberculosis-diabetes-co-morbidity-upon-standard-tuberculosis-treatment
#9
Nathella Pavan Kumar, Kadar Moideen, Shanmugam Sivakumar, Pradeep A Menon, Vijay Viswanathan, Hardy Kornfeld, Subash Babu
Type 2 diabetes mellitus (DM) is a major risk factor for the development of active pulmonary tuberculosis (PTB), with development of DM pandemic in countries where tuberculosis (TB) is also endemic. However, the effect of anti-TB treatment on the changes in dentritic cell (DC) and monocyte subset phenotype in TB-DM co-morbidity is not well understood. In this study, we characterized the frequency of DC and monocyte subsets in individuals with PTB with (PTB-DM) or without coincident diabetes mellitus (PTB-NDM) before, during and after completion of anti-TB treatment...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27864474/complement-component-3-regulates-ifn-%C3%AE-production-by-plasmacytoid-dendritic-cells-following-tlr7-activation-by-a-plant-virus-like-nanoparticle
#10
Marie-Ève Lebel, Marie-Pierre Langlois, Jean-François Daudelin, Esther Tarrab, Pierre Savard, Denis Leclerc, Alain Lamarre
The increasing use of plant viruses for the development of new vaccines and immunotherapy approaches poses questions regarding the mechanism by which the mammalian immune system recognizes these viruses. For example, although natural Abs (NA) and complement are key components of the innate immune system involved in the opsonization, phagocytosis, and destruction of microorganisms infecting mammals, their implication in plant virus recognition and immunogenicity is not well defined. In this study, we address the involvement of NA and the complement system in the activation of innate immunity through engagement of TLR7 with papaya mosaic virus (PapMV)-like nanoparticles...
November 18, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27863141/uvb-irradiation-causes-sting-dependent-production-of-protective-type-1-interferon-in-the-skin-by-recruited-inflammatory-monocytes
#11
Clayton Sontheimer, Denny Liggitt, Keith B Elkon
Objective Photosensitivity is common in patients with systemic lupus, though the mechanisms linking ultraviolet light to flares is not well understood. Here, we asked whether repetitive UVB exposure could induce Type I interferon (IFN-I) in normal mouse skin, and investigated the roles of inflammatory monocytes and plasmacytoid dendritic cells (PDCs) in IFN-I production and development of UVB-induced inflammation. Methods Mice were irradiated with UVB at 100 mJ/cm(2) for five days and cutaneous manifestations examined by mRNA expression of inflammatory and IFN-I response genes, histology, and flow cytometry...
November 11, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27855321/plasmacytoid-dendritic-cells-in-autoimmunity
#12
REVIEW
Santosh K Panda, Roland Kolbeck, Miguel A Sanjuan
Plasmacytoid dendritic cells (pDC) is a unique cell population that produces large amounts of type I interferon upon recognition of nucleic acids placing them at the crossroad of both innate and adaptive immunity. Their ability to produce interferon makes them central to anti-viral responses. They are also responsive to circulating autoantibodies bound to nuclear antigens and in that scenario the release of interferons initiate self-directed immune responses. There are now a growing number of autoimmune disorders where unabated activation of pDC is suspected to be pathogenic...
November 14, 2016: Current Opinion in Immunology
https://www.readbyqxmd.com/read/27853652/human-blood-myeloid-and-plasmacytoid-dendritic-cells-cross-activate-each-other-and-synergize-in-inducing-nk-cell-cytotoxicity
#13
Jasper J P van Beek, Mark A J Gorris, Annette E Sköld, Ibrahim Hatipoglu, Heleen H Van Acker, Evelien L Smits, I Jolanda M de Vries, Ghaith Bakdash
Human blood dendritic cells (DCs) hold great potential for use in anticancer immunotherapies. CD1c(+) myeloid DCs and plasmacytoid DCs (pDCs) have been successfully utilized in clinical vaccination trials against melanoma. We hypothesize that combining both DC subsets in a single vaccine can further improve vaccine efficacy. Here, we have determined the potential synergy between the two subsets in vitro on the level of maturation, cytokine expression, and effector cell induction. Toll-like receptor (TLR) stimulation of CD1c(+) DCs induced cross-activation of immature pDCs and vice versa...
2016: Oncoimmunology
https://www.readbyqxmd.com/read/27852745/dectin-1-plays-an-important-role-in-house-dust-mite-induced-allergic-airway-inflammation-through-the-activation-of-cd11b-dendritic-cells
#14
Takashi Ito, Koichi Hirose, Ayako Norimoto, Tomohiro Tamachi, Masaya Yokota, Aiko Saku, Hiroaki Takatori, Shinobu Saijo, Yoichiro Iwakura, Hiroshi Nakajima
It is well known that sensitization against fungi is closely associated with severity of asthma. Dectin-1 (gene symbol Clec7a), a C-type lectin receptor, recognizes the fungal cell wall component β-glucan, as well as some component(s) in house dust mite (HDM) extract. However, the roles of Dectin-1 in HDM-induced allergic airway inflammation remain unclear. In this study, we used Dectin-1-deficient (Clec7a(-/-)) mice to examine whether Dectin-1 is involved in HDM-induced allergic airway inflammation. We found that HDM-induced eosinophil and neutrophil recruitment into the airways was significantly attenuated in Clec7a(-/-) mice compared with that in wild-type mice...
November 16, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27848952/crucial-role-of-plasmacytoid-dendritic-cells-in-the-development-of-acute-colitis-through-the-regulation-of-intestinal-inflammation
#15
K Arimura, H Takagi, T Uto, T Fukaya, T Nakamura, N Choijookhuu, Y Hishikawa, Y Yamashita, K Sato
Disruption of intestinal homeostasis can lead to inflammatory bowel diseases endowed susceptibility genes and environmental factors affecting intestinal accumulation and activation of colitogenic phagocytes. Plasmacytoid dendritic cells (pDCs) are immune cells that had been proposed to control innate and adaptive immunity through the massive secretion of type I interferon (IFN-I). However, the contribution of pDCs to the progression of intestinal inflammation remains unclear. Here we show a critical role of pDCs in the initiation of acute colonic inflammation using T-cell-independent acute colitis model with a selective ablation of pDCs...
November 16, 2016: Mucosal Immunology
https://www.readbyqxmd.com/read/27846392/a-druggable-tcf4-and-brd4-dependent-transcriptional-network-sustains-malignancy-in-blastic-plasmacytoid-dendritic-cell-neoplasm
#16
Michele Ceribelli, Zhiying Esther Hou, Priscilla N Kelly, Da Wei Huang, George Wright, Karthik Ganapathi, Moses O Evbuomwan, Stefania Pittaluga, Arthur L Shaffer, Guido Marcucci, Stephen J Forman, Wenming Xiao, Rajarshi Guha, Xiaohu Zhang, Marc Ferrer, Laurence Chaperot, Joel Plumas, Elaine S Jaffe, Craig J Thomas, Boris Reizis, Louis M Staudt
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive and largely incurable hematologic malignancy originating from plasmacytoid dendritic cells (pDCs). Using RNAi screening, we identified the E-box transcription factor TCF4 as a master regulator of the BPDCN oncogenic program. TCF4 served as a faithful diagnostic marker of BPDCN, and its downregulation caused the loss of the BPDCN-specific gene expression program and apoptosis. High-throughput drug screening revealed that bromodomain and extra-terminal domain inhibitors (BETis) induced BPDCN apoptosis, which was attributable to disruption of a BPDCN-specific transcriptional network controlled by TCF4-dependent super-enhancers...
November 14, 2016: Cancer Cell
https://www.readbyqxmd.com/read/27846385/an-unexpected-chink-in-the-transcriptional-armor-of-plasmacytoid-dendritic-neoplasms
#17
Maria Kleppe, Ross L Levine
In this issue of Cancer Cell, Ceribelli et al. use functional genomic and chemical screening to reveal the existence of a TCF4/BRD4-dependent oncogenic regulatory network in blastic plasmacytoid dendritic cell neoplasm (BPDCN) and demonstrate that BPDCN cells are highly sensitive to therapeutic targeting of this novel dependency.
November 14, 2016: Cancer Cell
https://www.readbyqxmd.com/read/27837108/characterization-and-transcriptomic-analysis-of-porcine-blood-conventional-and-plasmacytoid-dendritic-cells-reveals-striking-species-specific-differences
#18
Gael Auray, Irene Keller, Sylvie Python, Markus Gerber, Remy Bruggmann, Nicolas Ruggli, Artur Summerfield
Porcine dendritic cells (DCs) are relatively well characterized, but a clear-cut identification of all DC subsets combined with full transcriptional profiling was lacking, preventing an unbiased insight into the functional specializations of DC subsets. Using a large panel of Abs in multicolor flow cytometry, cell sorting, and RNA sequencing we identified and characterized the porcine equivalent of conventional DCs (cDC) 1 and cDC2 as well as plasmacytoid DCs (pDCs) in the peripheral blood of pigs. We demonstrate that cDC1 are CD135(+)CD14(-)CD172a(low)CADM1(+)wCD11R1(+) cells, cDC2 are CD135(+)CD14(-)CD172a(+)CADM1(+)CD115(+)wCD11R1(+)CD1(+) cells and pDCs are CD4(+)CD135(+)CD172a(+)CD123(+)CD303(+) cells...
December 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27827374/microbiota-induces-tonic-ccl2-systemic-levels-that-control-pdc-trafficking-in-steady-state
#19
M Swiecki, H L Miller, R Sesti-Costa, M Cella, S Gilfillan, M Colonna
Plasmacytoid dendritic cells (pDCs) detect viruses initiating antiviral type I interferon responses. The microbiota is known to shape immune responses, but whether it influences pDC homeostasis and/or function is poorly understood. By comparing pDCs in germ-free and specific pathogen-free mice, we found that the microbiota supports homeostatic trafficking by eliciting constitutive levels of the chemokine CCL2 that engages CCR2. Mononuclear phagocytes were required for tonic CCL2 levels. CCL2 was particularly important for trafficking of a CCR2(hi) subset of pDCs that produced proinflammatory cytokines and was prone to apoptosis...
November 9, 2016: Mucosal Immunology
https://www.readbyqxmd.com/read/27823644/a-critical-review-of-treatment-modalities-for-blastic-plasmacytoid-dendritic-cell-neoplasm
#20
REVIEW
Umberto Falcone, Hassan Sibai, Uday Deotare
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a clinically aggressive tumor derived from the precursors of plasmacytoid dendritic cells. It is a rare disease presenting across all ages with either skin or both skin and bone marrow involvement often conferring a poor prognosis. Though localized radiation has been used before, acute leukemia based regimens, remains the treatment of choice for induction of remission. Hematopoietic stem cell transplant, either autologous or allogeneic, is further required for attaining sustained remissions...
November 2016: Critical Reviews in Oncology/hematology
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