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Angela Peron, Aglaia Vignoli, Francesca La Briola, Emanuela Morenghi, Lucia Tansini, Rosa Maria Alfano, Gaetano Bulfamante, Silvia Terraneo, Filippo Ghelma, Giuseppe Banderali, David H Viskochil, John C Carey, Maria Paola Canevini
Tuberous Sclerosis Complex (TSC) is a multisystemic condition caused by mutations in TSC1 or TSC2, but a pathogenic variant is not identified in up to 10% of the patients. The aim of this study was to delineate the phenotype of pediatric and adult patients with a definite clinical diagnosis of TSC and no mutation identified in TSC1 or TSC2. We collected molecular and clinical data of 240 patients with TSC, assessing over 50 variables. We compared the phenotype of the homogeneous group of individuals with No Mutation Identified (NMI) with that of TSC patients with a TSC1 and TSC2 pathogenic variant...
February 9, 2018: European Journal of Medical Genetics
Linyuan Feng, Jingxue Sheng, Gia-Phong Vu, Yujun Liu, Chingman Foo, Songbin Wu, Phong Trang, Marco Paliza-Carre, Yanhong Ran, Xiaoping Yang, Xu Sun, Zemin Deng, Tianhong Zhou, Sangwei Lu, Hongjian Li, Fenyong Liu
Interferon-γ (IFN-γ) represents one of the most important innate immunity responses in a host to combat infections of many human viruses including human herpesviruses. Human N-myc interactor (Nmi) protein, which has been shown to interact with signal transducer and activator of transcription (STAT) proteins including STAT1, is important for the activation of IFN-γ induced STAT1-dependent transcription of many genes responsible for IFN-γ immune responses. However, no proteins encoded by herpesviruses have been reported to interact with Nmi and inhibit Nmi-mediated activation of IFN-γ immune responses to achieve immune evasion from IFN-γ responses...
January 29, 2018: PLoS Pathogens
Dongdong Jian, Weina Wang, Xinmiao Zhou, Zhen Jia, Jing Wang, Mei Yang, Wenting Zhao, Zhen Jiang, Xiaotong Hu, Jianhua Zhu
AIM: Endothelial recovery, or re-endothelialization, plays an important role in intimal hyperplasia and atherosclerosis after endothelial injury. Studying the mechanisms of re-endothelialization and strategies to promote efficient endothelial recovery are still needed. Interferon-induced protein 35 (IFI35) is an IFN-γ-induced protein that plays important roles in the anti-virus-related immune-inflammatory response. In this study, we tested whether overexpression IFI35 affects the proliferation and migration of endothelial cells (ECs) and re-endothelialization...
January 19, 2018: Acta Physiologica
Tuba Sevimoglu, Beste Turanli, Ceyhun Bereketoglu, Kazim Yalcin Arga, Ayse Serap Karadag
Psoriasis is a complex autoimmune disease with multiple genes and proteins being involved in its pathogenesis. Despite the efforts performed to understand mechanisms of psoriasis pathogenesis and to identify diagnostic and prognostic targets, disease-specific and effective biomarkers were still not available. This study is compiled regarding clinical validation of computationally proposed biomarkers at gene and protein expression levels through qRT-PCR and ELISA techniques using skin biopsies and blood plasma...
January 9, 2018: Gene
Hawley C Pruitt, Brandon J Metge, Shannon E Weeks, Dongquan Chen, Shi Wei, Robert A Kesterson, Lalita A Shevde, Rajeev S Samant
The process of organ development requires a delicate balance between cellular plasticity and differentiation. This balance is disrupted in cancer initiation and progression. N-Myc and STAT interactor (NMI: human or Nmi: murine) has emerged as a relevant player in the etiology of breast cancer. However, a fundamental understanding of its relevance to normal mammary biology is lacking. To gain insight into its normal function in mammary gland, we generated a mammary-specific Nmi knockout mouse model. We observed that Nmi protein expression is induced in mammary epithelium at the onset of pregnancy, in luminal cells and persists throughout lactation...
January 12, 2018: Oncogene
Laura Buttrum, Lindsey Ledbetter, Rama Cherla, Yan Zhang, William J Mitchell, Guoquan Zhang
To understand the role of class I major histocompatibility complex (MHC-I) and class II MHC (MHC-II) antigen presentation pathways in host defense against C. burnetii infection, we examined if MHC-I or MHC-II deficiency in mice would significantly influence their susceptibility to virulent C. burnetii Nine Mile phase I (NMI) infection. The results indicate that NMI infection induced more severe disease in both MHC-I deficient and MHC-II deficient mice compared to WT mice, while only MHC-I deficient mice developed a severe persistent infection and were unable to control bacterial replication...
January 8, 2018: Infection and Immunity
Jake Jk Goh
BACKGROUND: Since 2016, the Naval Diving Unit (NDU) of the Republic of Singapore Navy (RSN) has instituted a smoking cessation trial program for their trainees, instituting a blanket ban on smoking during training hours in order to promote smoking cessation and create a smoke-free culture among its servicemen. For the rest of RSN personnel, they would attend a more costly, established Health Promotion Board (HPB) smoking cessation program, which employs social support strategies, while they undergo basic training in the Navy Military Experts Institute (NMI)...
November 2017: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
Sheffali Gulati, Harsh Patel, Biswaroop Chakrabarty, Rachana Dubey, N K Arora, R M Pandey, Vinod K Paul, Konanki Ramesh, Vyshakh Anand, Ankit Meena
Introduction: There is shortage of specialists for the diagnosis of children with neuromotor impairments (NMIs), especially in resource limited settings. Existing International Clinical Epidemiology Network (INCLEN) instrument for diagnosing NMI have been validated for children aged 2-9 years. The current study modified the same including wider symptomatology and age group (1 month to 18 years). Methods: The Modified INCLEN diagnostic tool (INDT) was developed by a team of experts by modifying the existing tool to widen the age range (1 month to 18 years) and include broader symptomatology (inclusion of milestones from the first 2 years of life and better elucidation of cerebellar and extrapyramidal features) in a tertiary care teaching hospital of North India between January and April 2015...
2017: Frontiers in Public Health
A J Fenwick, J L Wevrett, K M Ferreira, A M Denis-Bacelar, A P Robinson
In External Beam Radiotherapy, National Metrology Institutes (NMIs) play a critical role in the delivery of accurate absorbed doses to patients undergoing treatment. In contrast for nuclear medicine the role of the NMI is less clear and although significant work has been done in order to establish links for activity measurement, the calculation of administered absorbed doses is not traceable in the same manner as EBRT. Over recent decades the use of novel radiolabelled pharmaceuticals has increased dramatically...
November 11, 2017: Applied Radiation and Isotopes
Yu-Hsiang Fu, Chung-Yuan Huang, Chuen-Tsai Sun
The authors use four criteria to examine a novel community detection algorithm: (a) effectiveness in terms of producing high values of normalized mutual information (NMI) and modularity, using well-known social networks for testing; (b) examination, meaning the ability to examine mitigating resolution limit problems using NMI values and synthetic networks; (c) correctness, meaning the ability to identify useful community structure results in terms of NMI values and Lancichinetti-Fortunato-Radicchi (LFR) benchmark networks; and (d) scalability, or the ability to produce comparable modularity values with fast execution times when working with large-scale real-world networks...
2017: PloS One
Jingjing Hou, Shihao Jiang, Jiabao Zhao, Dong Zhu, Xinmeng Zhao, Jian-Chun Cai, Si Qing Zhang
NF-κB is a major regulator of gene transcription involved in immune, inflammation, apoptosis and stress responses. However, the regulation of NF-κB is not completely understood. Here, we report that the N-Myc and STATs Interactor (NMI), an IFN-inducible protein, is an important negative regulator of NF-κB activity. We found that NMI negatively regulates TNF-α-induced IL-6 and IL-1β production in HeLa cells. Overexpression of NMI inhibits NF-κB transcriptional activity, in contrast, depletion of NMI by shRNA increases NF-κB transcriptional activity...
November 6, 2017: Scientific Reports
Ashok Keerthi, Boya Radha, Daniele Rizzo, Hao Lu, Valentin Diez Cabanes, Ian Cheng-Yi Hou, David Beljonne, Jérôme Cornil, Cinzia Casiraghi, Martin Baumgarten, Klaus Müllen, Akimitsu Narita
Edge functionalization of bottom-up synthesized graphene nanoribbons (GNRs) with anthraquinone and naphthalene/perylene monoimide units has been achieved through a Suzuki coupling of polyphenylene precursors bearing bromo groups, prior to the intramolecular oxidative cyclo-dehydrogenation. High efficiency of the substitution has been validated by MALDI-TOF MS analysis of the functionalized precursors and FT-IR, Raman, and XPS analyses of the resulting GNRs. Moreover, AFM measurements demonstrated the modulation of the self-assembling behavior of the edge-functionalized GNRs, revealing that GNR-PMI formed an intriguing rectangular network...
November 9, 2017: Journal of the American Chemical Society
Esther Sok Hwee Cheow, Woo Chin Cheng, Terence Yap, Bamaprasad Dutta, Chuen Neng Lee, Dominique P V de Kleijn, Vitaly Sorokin, Siu Kwan Sze
The lack of precise biomarkers that identify patients at risk for myocardial injury and stable angina delays administration of optimal therapy. Hence, the search for noninvasive biomarkers that could accurately stratify patients with impending heart attack, from patients with stable coronary artery disease (CAD), is urgently needed in the clinic. Herein, we performed comparative quantitative proteomics on whole plasma sampled from patients with stable angina (NMI), acute myocardial infarction (MI), and healthy control subjects (Ctrl)...
November 7, 2017: Journal of Proteome Research
Yi Wang, Ke Chen, Leanne L H Chan
To study the information transmission in the primary visual cortex (V1) of retinal degenerated (RD) models, wild type (WT) and RD rats were used in the experiments. The neural response in V1 was recorded extracellularly while the flicker with varied intensity levels was given as the visual stimulus. The mutual information (MI) and normalized mutual information (NMI) were determined for every isolated neuron, in order to quantify the amount and efficiency of information transmission in V1 of both control and experimental groups...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Adrian Bingham, Sridhar P Arjunan, Dinesh K Kumar
In this study we investigated a technique for estimating the progression of localized muscle fatigue. This technique measures the dependence between motor units using high density surface electromyogram (HD-sEMG) and is based on the Normalized Mutual Information (NMI) measure. The NMI between every pair combination of the electrode array is computed to measure the interactions between electrodes. Participants in the experiment had an array of 64 electrodes (16 by 4) placed over the TA of their dominate leg such that the columns of the array ran parallel with the muscle fibers...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Trieu Phat Luu, Justin A Brantley, Fangshi Zhu, Jose L Contreras-Vidal
This study investigates if the electrocortical amplitude modulations relative to the mean gait cycle are different across walking conditions (i.e., level-ground (LW), ramp ascent (RA), and stair ascent (SA)). Non-invasive electroencephalography (EEG) signals were recorded and a systematic EEG processing method was implemented to reduce artifacts. Source localization using independent component analysis and k-means clustering revealed the involvement of four clusters in the brain (Left and Right Occipital Lobe, Posterior Parietal Cortex (PPC), and Sensorimotor Area) during the walking tasks...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Henry Candra, Mitchell Yuwono, Rifai Chai, Hung T Nguyen, Steven Su
Recognizing emotion from EEG signals is a complicated task that requires complex features and a substantial number of EEG channels. Simple algorithms to analyse the feature and reduce the EEG channel number will give an indispensable advantages. Therefore, this study explores a combination of wavelet entropy and average wavelet coefficient (WEAVE) as a potential EEG-emotion feature to classify valence and arousal emotions with the advantage of the ability to identify the occurrence of a pattern while at the same time identify the shape of a pattern in EEG emotion signal...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Yosra Saidane, Sofia Ben Jebara
This study investigates the effect of preparation warning on the functional connectivity between forearm muscles during movement's initiation. The Normalized Mutual Information (NMI) is the used indicator. It is calculated for muscle pairs activated during a handgrip exercice. They are innervated by the same nerve or by different nerves. Results show that: i) NMI is more important when muscles pairs are stimulated by the same nerve during both preparation and motor activities. ii) NMI is higher during preparation comparing to motor activity...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Zhikai Xiahou, Xiangli Wang, Juan Shen, Xiaoxiao Zhu, Feng Xu, Rong Hu, Deyin Guo, Henan Li, Yong Tian, Yingfang Liu, Huanhuan Liang
Damage-associated molecular patterns (DAMP) trigger innate immune response and exacerbate inflammation to combat infection and cellular damage. Identifying DAMPs and revealing their functions are thus of crucial importance. Here we report that two molecules, N-myc and STAT interactor (NMI) and interferon-induced protein 35 (IFP35) act as DAMPs and are released by activated macrophages during lipopolysaccharide-induced septic shock or acetaminophen-induced liver injury. We show that extracellular NMI and IFP35 activate macrophages to release proinflammatory cytokines by activating nuclear factor-κB through the Toll-like receptor 4 pathway...
October 16, 2017: Nature Communications
Dan Song, Jiabao Zhao, Chen Su, Ying Jiang, Jingjing Hou
Lung carcinoma is one of the leading causes of cancer-related death. The N-Myc and STATs interactor (NMI) has been reported to take participate in lots of physiological processes, but the involvement and functional mechanisms of NMI in lung carcinoma are poorly understood. In this study, we found that etoposide induces proliferation suppression, cell apoptosis and increases caspase-3 activity in A549 cells. Furthermore, etoposide treatment up-regulates the expression of NMI and ARF, enhances the interaction of NMI and ARF and promotes the p53 transcriptional activities...
October 10, 2017: Biochemical and Biophysical Research Communications
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