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https://www.readbyqxmd.com/read/28335553/biosynthesis-of-polyunsaturated-fatty-acids-in-octopus-vulgaris-molecular-cloning-and-functional-characterisation-of-a-stearoyl-coa-desaturase-and-an-elongation-of-very-long-chain-fatty-acid-4-protein
#1
Óscar Monroig, Rosa de Llanos, Inmaculada Varó, Francisco Hontoria, Douglas R Tocher, Sergi Puig, Juan C Navarro
Polyunsaturated fatty acids (PUFAs) have been acknowledged as essential nutrients for cephalopods but the specific PUFAs that satisfy the physiological requirements are unknown. To expand our previous investigations on characterisation of desaturases and elongases involved in the biosynthesis of PUFAs and hence determine the dietary PUFA requirements in cephalopods, this study aimed to investigate the roles that a stearoyl-CoA desaturase (Scd) and an elongation of very long-chain fatty acid 4 (Elovl4) protein play in the biosynthesis of essential fatty acids (FAs)...
March 21, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28316812/crystal-structure-of-1-methylimidazole-3-oxide-monohydrate
#2
Christopher S Frampton, James I Murray, Alan C Spivey
1-Methylimidazole 3-N-oxide (NMI-O) crystallizes as a monohydrate, C4H6N2O·H2O, in the monoclinic space group P21 with Z' = 2 (mol-ecules A and B). The imidazole rings display a planar geometry (r.m.s. deviations = 0.0008 and 0.0002 Å) and are linked in the crystal structure into infinite zigzag strands of ⋯NMI-O(A)⋯OH2⋯NMI-O(B)⋯OH2⋯ units by O-H⋯O hydrogen bonds. These chains propagate along the b-axis direction of the unit cell.
March 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28289791/-predictors-of-cognitive-outcome-in-ventilated-early-rehabilitation-patients
#3
M-D Heidler, L Bidu, H Völler, A Salzwedel
BACKGROUND: After weaning failure, patients who are transferred from intensive care units to early rehabilitation centers (ERC) not only suffer from motor deficits but also from cognitive deficits. It is still uncertain which patient factors have an impact on cognitive outcome at the end of early rehabilitation. OBJECTIVE: Investigation of predictors of cognitive performance for initially ventilated early rehabilitation patients. METHODS: A total of 301 patients (mean age 68...
March 13, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/28269308/corticomuscular-coherence-variation-throughout-the-gait-cycle-during-overground-walking-and-ramp-ascent-a-preliminary-investigation
#4
Anna T Winslow, Justin Brantley, Fangshi Zhu, Jose L Contreras Vidal, He Huang
Recent designs of neural-machine interfaces (NMIs) incorporating electroencephalography (EEG) or electromyography (EMG) have been used in lower limb assistive devices. While the results of previous studies have shown promise, a NMI which takes advantage of early movement-related EEG activity preceding movement onset, as well as the improved signal-to-noise ratio of EMG, could prove to be more accurate and responsive than current NMI designs based solely on EEG or EMG. Previous studies have demonstrated that the activity of the sensorimotor cortex is coupled to the firing rate of motor units in lower limb muscles during voluntary contraction...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28269307/tolerance-of-neural-decoding-errors-for-powered-artificial-legs-a-pilot-study
#5
Fan Zhang, Ming Liu, He Huang
Neural-machine interface (NMI) decoding errors challenge the clinical value of neural control of powered artificial legs, because these errors can dangerously disturb the user's walking balance, cause stumbles or falls, and thus threaten the user's confidence and safety in prosthesis use. Although extensive research efforts have been made to minimize the NMI decoding error rate, none of the current approaches can completely eliminate the errors in NMI. This study aimed at improving the robustness of prosthesis control system against neural decoding errors by introducing a fault-tolerant control (FTC) strategy...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28269086/estimating-the-progression-of-muscle-fatigue-based-on-dependence-between-motor-units-using-high-density-surface-electromyogram
#6
Adrian Bingham, Sridhar P Arjunan, Dinesh K Kumar
In this study we have tested the hypothesis regarding the increase in synchronization with the onset of muscle fatigue. For this aim, we have investigated the difference in the synchronicity between high density surface electromyogram (sEMG) channels of the rested muscles and when at the limit of endurance. Synchronization was measured by computing and normalizing the mutual information between the sEMG signals recorded from the high-density array electrode locations. Ten volunteers (Age range: 21 and 35 years; Mean age = 26 years; Male = 6, Female = 4) participated in our experiment...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28229337/novel-odd-chain-fatty-acids-with-a-terminal-double-bond-in-ovaries-of-the-limpet-cellana-toreuma
#7
Hideki Kawashima, Masao Ohnishi
Our previous study characterized highly diverse dienoic fatty acids (FA), in particular an uncommon non-methylene-interrupted (NMI) FA, in the ovaries of the Japanese limpet Cellana toreuma belonging to the archaeogastropods, but many minor chemically unidentified FA remain. In this study, among previously unidentified FA (less than 0.1% of total FA), four novel NMI FA with a terminal double bond [7,18-nonadecadienoic (19:2Δ7,18), 11,18-nonadecadienoic (19:2Δ11,18), 7,20-heneicosadienoic (21:2Δ7,20), and 11,20-heneicosadienoic (21:2Δ11,20) acids] were found, along with known 14-pentadecenoic (15:1Δ14), 16-heptadecenoic (17:1Δ16), and 9,18-nonadecadienoic (19:2Δ9,18) acids, based on capillary GC-MS of their methyl esters, 3-pyridylcarbinol derivatives, and argentation thin-layer chromatography...
February 23, 2017: Lipids
https://www.readbyqxmd.com/read/28227545/corticomuscular-coherence-variation-throughout-the-gait-cycle-during-overground-walking-and-ramp-ascent-a-preliminary-investigation
#8
Anna T Winslow, Justin Brantley, Fangshi Zhu, Jose L Contreras Vidal, He Huang, Anna T Winslow, Justin Brantley, Fangshi Zhu, Jose L Contreras Vidal, He Huang, Fangshi Zhu, Justin Brantley, Jose L Contreras Vidal, He Huang, Anna T Winslow
Recent designs of neural-machine interfaces (NMIs) incorporating electroencephalography (EEG) or electromyography (EMG) have been used in lower limb assistive devices. While the results of previous studies have shown promise, a NMI which takes advantage of early movement-related EEG activity preceding movement onset, as well as the improved signal-to-noise ratio of EMG, could prove to be more accurate and responsive than current NMI designs based solely on EEG or EMG. Previous studies have demonstrated that the activity of the sensorimotor cortex is coupled to the firing rate of motor units in lower limb muscles during voluntary contraction...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227544/tolerance-of-neural-decoding-errors-for-powered-artificial-legs-a-pilot-study
#9
Fan Zhang, Ming Liu, He Huang, Fan Zhang, Ming Liu, He Huang, He Huang, Ming Liu, Fan Zhang
Neural-machine interface (NMI) decoding errors challenge the clinical value of neural control of powered artificial legs, because these errors can dangerously disturb the user's walking balance, cause stumbles or falls, and thus threaten the user's confidence and safety in prosthesis use. Although extensive research efforts have been made to minimize the NMI decoding error rate, none of the current approaches can completely eliminate the errors in NMI. This study aimed at improving the robustness of prosthesis control system against neural decoding errors by introducing a fault-tolerant control (FTC) strategy...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227307/estimating-the-progression-of-muscle-fatigue-based-on-dependence-between-motor-units-using-high-density-surface-electromyogram
#10
Adrian Bingham, Sridhar P Arjunan, Dinesh K Kumar, Adrian Bingham, Sridhar P Arjunan, Dinesh K Kumar, Adrian Bingham, Dinesh K Kumar, Sridhar P Arjunan
In this study we have tested the hypothesis regarding the increase in synchronization with the onset of muscle fatigue. For this aim, we have investigated the difference in the synchronicity between high density surface electromyogram (sEMG) channels of the rested muscles and when at the limit of endurance. Synchronization was measured by computing and normalizing the mutual information between the sEMG signals recorded from the high-density array electrode locations. Ten volunteers (Age range: 21 and 35 years; Mean age = 26 years; Male = 6, Female = 4) participated in our experiment...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28222923/consumption-of-aquaculture-waste-affects-the-fatty-acid-metabolism-of-a-benthic-invertebrate
#11
Camille A White, Raymond J Bannister, Symon A Dworjanyn, Vivian Husa, Peter D Nichols, Tina Kutti, Tim Dempster
Trophic subsidies can drive widespread ecological change, thus knowledge of how keystone species respond to subsidies is important. Aquaculture of large carnivorous fish generates substantial waste as faeces and lost feed, providing a food source to mobile benthic invertebrates. We used a controlled feeding study combined with a field survey to better understand the interaction between salmon aquaculture and the sea urchin, Echinus acutus, a dominant mobile invertebrate in Norwegian fjords. We tested if diets affected urchin fatty acid composition by feeding them one of three diet treatments ("aquafeed", "composite" and "natural") for 10weeks...
May 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28218662/microrna-expression-profile-identifies-high-grade-non-muscle-invasive-bladder-tumors-at-elevated-risk-to-progress-to-an-invasive-phenotype
#12
Sara M Lenherr, Sheaumei Tsai, Brasil Silva Neto, Travis B Sullivan, Cara B Cimmino, Tanya Logvinenko, Jason Gee, Wei Huang, John A Libertino, Ian C Summerhayes, Kimberly M Rieger-Christ
The objective of this study was to identify a panel of microRNAs (miRNAs) differentially expressed in high-grade non-muscle invasive (NMI; TaG3-T1G3) urothelial carcinoma that progress to muscle-invasive disease compared to those that remain non-muscle invasive, whether recurrence happens or not. Eighty-nine high-grade NMI urothelial carcinoma lesions were identified and total RNA was extracted from paraffin-embedded tissue. Patients were categorized as either having a non-muscle invasive lesion with no evidence of progression over a 3-year period or as having a similar lesion showing progression to muscle invasion over the same period...
February 17, 2017: Genes
https://www.readbyqxmd.com/read/28194557/-4z-15z-octadecadienoic-acid-inhibits-glycogen-synthase-kinase-3%C3%AE-and-glucose-production-in-h4iie-cells
#13
Jun Yoshida, Shota Uesugi, Tetsuaki Kawamura, Ken-Ichi Kimura, Dawei Hu, Shuang Xia, Naoki Toyooka, Masao Ohnishi, Hideki Kawashima
Many uncommon non-methylene-interrupted fatty acids (NMI FA) are present in limpet gonads, but their biological properties remain unknown. To investigate new biological effects of naturally occurring NMI FA in eukaryotic cells, the biological activities of structurally analogous (4Z,15Z)-octadecadienoic acid (1), (9Z,20Z)-tricosadienoic acid (2), and (12Z,23Z)-hexacosadienoic acid (3) were examined by using a yeast-based drug-screening system using the Ca(2+)-sensitive mutant strain, Saccharomyces cerevisiae (zds1Δ erg3Δ pdr1Δ pdr3Δ)...
March 2017: Lipids
https://www.readbyqxmd.com/read/28189091/standardization-of-68-ge-68-ga-using-4%C3%AF-%C3%AE-ls-%C3%AE-coincidence-counting-system-for-activity-measurements
#14
D B Kulkarni, Leena Joseph, R Anuradha, M S Kulkarni, B S Tomar
(68)Ga has great scope for use in future for positron emission tomography (PET) imaging due to its very fast blood clearance and fast target localization, even though at present (18)F is widely used. (68)Ge in equilibrium with (68)Ga ((68)Ge-(68)Ga) can also be used as a surrogate for (18)F calibration, as (18)F source standardization can be done at national metrology institute (NMI) but, these standards cannot be sent to nuclear medicine centers (NMCs) across India for calibration of isotope calibrators, due to the short half-life of (18)F (110min)...
January 31, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28092127/induction-of-p450-genes-in-nilaparvata-lugens-and-sogatella-furcifera-by-two-neonicotinoid-insecticides
#15
Yuan-Xue Yang, Na Yu, Jian-Hua Zhang, Yi-Xi Zhang, Ze-Wen Liu
Nilaparvata lugens and Sogatella furcifera are two primary planthoppers on rice throughout Asian countries and areas. Neonicotinoid insecticides, such as imidacloprid (IMI), have been extensively used to control rice planthoppers and IMI resistance consequently occurred with an important mechanism from the over-expression of P450 genes. The induction of P450 genes by IMI may increase the ability to metabolize this insecticide in planthoppers and increase the resistance risk. In this study, the induction of P450 genes was compared in S...
January 16, 2017: Insect Science
https://www.readbyqxmd.com/read/28077802/nmi-promotes-hepatocellular-carcinoma-progression-via-bdkrb2-and-mapk-erk-pathway
#16
Jing Zhao, Qiong-Zhu Dong, Fan Zhong, Li-Li Cai, Zhao-Yu Qin, Yang Liu, Cheng-Zhao Lin, Lun-Xiu Qin, Fu-Chu He
Hepatocellular carcinoma (HCC) is one of the most prevalent and aggressive malignant tumors. The involvement of N-myc (and STAT) interactor (NMI) and its possible functional mechanisms in HCC progression still remain to be elucidated. In this study, we found that NMI was overexpressed in metastatic HCC cell lines compared with non-metastatic ones; and the expression levels of NMI in the HCC samples with metastasis were higher than that in the non-metastatic specimens. Furthermore, NMI depletion significantly decreased HCC cell proliferation and invasiveness in vitro, and also inhibited tumor growth and lung metastasis in vivo in nude mice models bearing human HCC...
January 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28067001/synthesis-and-investigation-of-anti-cancer-potential-of-radiolabelled-naphthalene-monoimide-bearing-imidazolium-salt
#17
Fatma Yurt Lambrecht, Kasim Ocakoglu, Suleyman Gokhan Colak, Onur Alp Ersoz, Ozge Er
Imidazolium salts and derivatives have anti-tumor efficacy and toxic effects in different microorganisms. In present study, an imidazolium bromide salt (NMI) was synthesized, and its antitumor potential was investigated by in vitro studies. Radiolabeling of synthesized NMI was carried out by iodogen method using (131) I radionuclide. The yield of radiolabeling was determined as 98.5±0.1%. After that, cytotoxicity and intracellular uptake studies were evaluated in various cell lines. The cytotoxicity of NMI was determined as 35 μM, 20 μM, 10 μM and 1 μM for HEK-293, PC-3, CaCo-2 and MCF-7 cells, respectively...
January 9, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28060526/effects-of-dual-monitor-computer-work-versus-laptop-work-on-cervical-muscular-and-proprioceptive-characteristics-of-males-and-females
#18
Amanda M Farias Zuniga, Julie N Côté
OBJECTIVE: The effects of performing a 90-minute computer task with a laptop versus a dual monitor desktop workstation were investigated in healthy young male and female adults. BACKGROUND: Work-related musculoskeletal disorders are common among computer (especially female) users. Laptops have surpassed desktop computer sales, and working with multiple monitors has also become popular. However, few studies have provided objective evidence on how they affect the musculoskeletal system in both genders...
December 1, 2016: Human Factors
https://www.readbyqxmd.com/read/28048653/tu-h-campus-jep1-01-characterization-of-a-parameterized-image-similarity-cost-function-for-automated-patient-and-site-specific-dir-accuracy-optimizations
#19
J Neylon, Y Min, K Hasse, D Low, A Santhanam
PURPOSE: Clinical deformable image registration (DIR) accuracy is difficult to quantify, making validation and verification manual and time consuming. It has also been seen that DIR accuracy can be improved by patient and site specific optimization. We previously investigated a cost function to parameterize image similarity metrics (ISMs) and provide a quantifiable comparison of DIR performance. In this abstract, we characterize and optimize the cost function response (CFR) and correlation to target registration error (TRE) in a dense registration parameter space...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047633/su-c-207b-06-comparison-of-registration-methods-for-modeling-pathologic-response-of-esophageal-cancer-to-chemoradiation-therapy
#20
S Riyahi, W Choi, N Bhooshan, S Tan, H Zhang, W Lu
PURPOSE: To compare linear and deformable registration methods for evaluation of tumor response to Chemoradiation therapy (CRT) in patients with esophageal cancer. METHODS: Linear and multi-resolution BSpline deformable registration were performed on Pre-Post-CRT CT/PET images of 20 patients with esophageal cancer. For both registration methods, we registered CT using Mean Square Error (MSE) metric, however to register PET we used transformation obtained using Mutual Information (MI) from the same CT due to being multi-modality...
June 2016: Medical Physics
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