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Afshin Samani, Divya Srinivasan, Svend Erik Mathiassen, Pascal Madeleine
The spatio-temporal distribution of muscle activity has been suggested to be a determinant of fatigue development. Pursuing this hypothesis, we investigated the pattern of muscular activity in the shoulder and arm during a repetitive dynamic task performed until participants' rating of perceived exertion reached 8 on Borg's CR-10 scale. We collected high-density surface electromyogram (HD-EMG) over the upper trapezius, as well as bipolar EMG from biceps brachii, triceps brachii, deltoideus anterior, serratus anterior, upper and lower trapezius from 21 healthy women...
October 14, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
Laura Schoenlaub, Rama Cherla, Yan Zhang, Guoquan Zhang
Our recent study demonstrated that virulent Coxiella burnetii Nine Mile phase I (NMI) is capable of infecting and replicating within peritoneal B1a cells and that B1a cells play an important role in host defense against C. burnetii infection in mice. However, it remains unknown if avirulent Nine Mile phase II (NMII) can infect and replicate in B1a cells and whether NMI and NMII can differentially interact with B1a cells. In this study, we examined if NMI and NMII can differentially modulate host cell apoptotic signaling in B1a cells...
October 10, 2016: Infection and Immunity
Manisa Kongkaew, Kannika Sitthisuwannakul, Vasut Nakarajouyphon, Soraya Pornsuwan, Palangpon Kongsaeree, Preeyanuch Sangtrirutnugul
A series of benzimidazole-triazole ligands (NN') having a pendent triazole arm with different triazole substituents including CH2Ph (3a), cyclo-C6H11 (3b), and CH2SiMe3 (3c) were obtained in moderate yields from Cu-catalyzed oxidative C-N cyclization of the respective amine-triazole compounds N,N'-bis((1-R-1,2,3-triazol-4-yl)methyl)benzene-1,2-diamine (2a-2c). Treatment of CuCl2 with one equiv. of the benzimidazole-triazole ligands afforded the corresponding Cu(II) complexes with the empirical formula of Cu(NN')Cl2 (4a-4c)...
September 22, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Shiqing Xu, Ei-Ichi Negishi
Carbometalation of alkenes with stereocontrol offers an important opportunity for asymmetric C-C bond formation. However, the scope of catalytic stereoselective carbometalation of alkenes had until recently been limited to electronically biased alkenes or those with the presence of directing groups or other auxiliary functionalities to overcome the challenge associated with regio- and stereoselectivity. Catalytic asymmetric carbometalation of unactivated alkenes on the other hand remained as a formidable challenge...
October 18, 2016: Accounts of Chemical Research
Keita Matsuura, Masayuki Maeda, Ken-Ichi Tabei, Maki Umino, Hiroyuki Kajikawa, Masayuki Satoh, Hirotaka Kida, Hidekazu Tomimoto
PURPOSE: Neuromelanin-sensitive MR imaging (NMI) is an increasingly powerful tool for the diagnosis of Parkinson's disease (PD). This study was undertaken to evaluate longitudinal changes on NMI in PD patients. METHODS: We examined longitudinal changes on NMI in 14 PD patients. The area and contrast ratio (CR) of the substantia nigra pars compacta (SNc) were comparatively analyzed. RESULTS: The total area and CR of the SNc upon follow-up NMI were significantly smaller than those on initial NMI (from 33...
October 28, 2016: Neuroscience Letters
Ana Rua-Ibarz, Eduardo Bolea-Fernandez, Amund Maage, Sylvia Frantzen, Stig Valdersnes, Frank Vanhaecke
Hg pollution released from the U-864 submarine sunk during WWII and potential introduction of that Hg into the marine food chain have been studied by a combination of quantitative Hg and MeHg determination and Hg isotopic analysis via cold vapor generation multicollector inductively coupled plasma-mass spectrometry (CVG-MC-ICP-MS) in sediment and Cancer pagurus samples. The sediment pollution could be unequivocally linked with the metallic Hg present in the wreck. Crabs were collected at the wreck location and 4 nmi north and south, and their brown and claw meat were analyzed separately...
October 4, 2016: Environmental Science & Technology
N C N Perera, G I Godahewa, Bo-Hye Nam, Jehee Lee
Interferons (IFNs) and IFN-inducible proteins play numerous physiological roles, particularly in antiviral defense mechanisms of the innate immune response with the presence of pathogens. IFN-induced protein-35 kDa (IFP35) is induced by Type II IFN (IFN-γ); it is a cytoplasmic protein that can be translocated to the nucleus via the stimulation of IFN. In this study, we report the complete molecular characterization of the IFP35 cDNA sequence from the black rockfish in an effort to understand its role in the immune response...
September 2016: Fish & Shellfish Immunology
Anne Kuijer, Kay Schreuder, Sjoerd G Elias, Carolien H Smorenburg, Emiel J T Rutgers, Sabine Siesling, Thijs van Dalen
BACKGROUND: Breast cancer guidelines suggest the use of gene expression profiles (GEPs) in estrogen receptor-positive (ER+) breast cancer patients in whom controversy exists regarding adjuvant chemotherapy benefit based on traditional prognostic factors alone. We evaluated the current use of GEPs in these patients in the Netherlands. PATIENTS AND METHODS: Primary breast cancer patients treated between January 1, 2011 and December 31, 2014 and eligible for GEP use according to the Dutch national breast cancer guideline were identified in the Netherlands Cancer Registry: ER+ patients <70 years with grade 1 tumors >2 cm or grade 2 tumors 1-2 cm without overt lymph node metastases (pN0-Nmi)...
2016: Public Health Genomics
Peymon M Gazi, Shadi Aminololama-Shakeri, Kai Yang, John M Boone
The development of a framework of deformable image registration and segmentation for the purpose of temporal subtraction contrast-enhanced breast CT is described. An iterative histogram-based two-means clustering method was used for the segmentation. Dedicated breast CT images were segmented into background (air), adipose, fibroglandular and skin components. Fibroglandular tissue was classified as either normal or contrast-enhanced then divided into tiers for the purpose of categorizing degrees of contrast enhancement...
September 7, 2016: Physics in Medicine and Biology
Pascal Madeleine, Yanfei Xie, Grace P Y Szeto, Afshin Samani
OBJECTIVE: To investigate the effects neck-shoulder pain on the connectivity of surface electromyography (SEMG) signals during functional tasks. METHODS: Twenty adults suffering from chronic neck-shoulder pain and 20 healthy controls were recruited. The SEMG signals from the left and right proximal cervical erector spinae, upper trapezius, lower trapezius and distal extensor carpi radialis, extensor digitorum, flexor digitorum superficialis and, abductor pollicis brevis were recorded during three functional tasks: unilateral and bilateral texting on a smart-phone and computer typing...
September 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
Miao Wang, Xingyuan Xiao, Fuqing Zeng, Fei Xie, Yebin Fan, Chao Huang, Guosong Jiang, Liang Wang
Our study aimed to explore long non-coding RNAs (lncRNAs) contributing to the development of bladder cancer, as well as to identify more critical DEGs and lncRNAs that would characterize low- and high-grade bladder cancer. The microarray data of GSE55433 was downloaded from Gene Expression Omnibus database, including 57 urothelial cancer samples (23 low-grade NMI, 14 high-grade NMI and 20 invasive tumors) and 26 normal controls. The differentially expressed genes (DEGs) and differentially expressed lncRNAs were identified in 3 groups (low-grade NMI vs...
October 30, 2016: Gene
Antony E Fernandes, Olivier Riant, Klavs F Jensen, Alain M Jonas
We describe a simple and general method for the preparation and molecular engineering of supported trifunctional catalysts and their application in the representative Cu/TEMPO/NMI-catalyzed aerobic oxidation of benzyl alcohol. The methodology allows in one single step to immobilize, with precise control of surface composition, both pyta, Cu(I) , TEMPO, and NMI sites on azide-functionalized silica particles. To optimize the performance of the heterogeneous trifunctional catalysts, synergistic interactions are finely engineered through modulating the degree of freedom of the imidazole site as well as tuning the relative surface composition, leading to catalysts with an activity significantly superior to the corresponding homogeneous catalytic system...
September 5, 2016: Angewandte Chemie
Roberto Sanseverino, Giorgio Napodano, Antonio Campitelli, Maria Addesso
PURPOSE: To evaluate whether pathological outcomes of ReTURB have a prognostic impact on recurrence and progression of primitive T1HG bladder cancer. MATERIAL AND METHODS: Patients affected by primitive T1HG TCC of bladder underwent restaging TURB (ReTURB). Patients with muscle invasive disease at ReTURB underwent radical cystectomy; those with non-muscle invasive residual (NMI-RT) and those with no residual tumour (NRT) received an intravesical BCG therapy. We compared recurrence and progression in NMIRT patients and NRT patients at restaging TURB...
2016: Archivio Italiano di Urologia, Andrologia
S Reaungamornrat, T De Silva, A Uneri, J-P Wolinsky, A J Khanna, G Kleinszig, S Vogt, J L Prince, J H Siewerdsen
PURPOSE: Localization of target anatomy and critical structures defined in preoperative MR images can be achieved by means of multi-modality deformable registration to intraoperative CT. We propose a symmetric diffeomorphic deformable registration algorithm incorporating a modality independent neighborhood descriptor (MIND) and a robust Huber metric for MR-to-CT registration. METHOD: The method, called MIND Demons, solves for the deformation field between two images by optimizing an energy functional that incorporates both the forward and inverse deformations, smoothness on the velocity fields and the diffeomorphisms, a modality-insensitive similarity function suitable to multi-modality images, and constraints on geodesics in Lagrangian coordinates...
February 27, 2016: Proceedings of SPIE
Sureerat Reaungamornrat, Tharindu De Silva, Ali Uneri, Sebastian Vogt, Gerhard Kleinszig, A J Khanna, Jean-Paul Wolinsky, Jerry L Prince, Jeffrey H Siewerdsen
Intraoperative localization of target anatomy and critical structures defined in preoperative MR/CT images can be achieved through the use of multimodality deformable registration. We propose a symmetric diffeomorphic deformable registration algorithm incorporating a modality-independent neighborhood descriptor (MIND) and a robust Huber metric for MR-to-CT registration. The method, called MIND Demons, finds a deformation field between two images by optimizing an energy functional that incorporates both the forward and inverse deformations, smoothness on the integrated velocity fields, a modality-insensitive similarity function suitable to multimodality images, and smoothness on the diffeomorphisms themselves...
June 2, 2016: IEEE Transactions on Medical Imaging
Yanbin Wang, Junzhong Ji, Peipeng Liang
Pattern classification has been increasingly used in functional magnetic resonance imaging (fMRI) data analysis. However, the classification performance is restricted by the high dimensional property and noises of the fMRI data. In this paper, a new feature selection method (named as "NMI-F") was proposed by sequentially combining the normalized mutual information (NMI) and fisher discriminant ratio. In NMI-F, the normalized mutual information was firstly used to evaluate the relationships between features, and fisher discriminant ratio was then applied to calculate the importance of each feature involved...
March 17, 2016: Journal of X-ray Science and Technology
Esther Sok Hwee Cheow, Woo Chin Cheng, Chuen Neng Lee, Dominique de Kleijn, Vitaly Sorokin, Siu Kwan Sze
Myocardial infarction (MI) triggers a potent inflammatory response via the release of circulatory mediators, including extracellular vesicles (EVs) by damaged cardiac cells, necessary for myocardial healing. Timely repression of inflammatory response are critical to prevent and minimize cardiac tissue injuries, nonetheless, progression in this aspect remains challenging. The ability of EVs to trigger a functional response upon delivery of carried bioactive cargos, have made them clinically attractive diagnostic biomarkers and vectors for therapeutic interventions...
August 2016: Molecular & Cellular Proteomics: MCP
Myungjoon Kim, Chiwon Lee, Woo Jung Park, Yun Suhk Suh, Han Kwang Yang, H Jin Kim, Sungwan Kim
BACKGROUND: Robot-assisted laparoscopic surgery offers several advantages compared with open surgery and conventional minimally invasive surgery. However, one issue that needs to be resolved is a collision between the robot arm and the assistant instrument. This is mostly caused by miscommunication between the surgeon and the assistant. To resolve this limitation, an assistant surgical robot system that can be simultaneously manipulated via a wireless controller is proposed to allow the surgeon to control the assistant instrument...
2016: Biomedical Engineering Online
Niravkumar R Patel, Aleksandr Piroyan, Abbegial H Nack, Corin A Galati, Mackenzi McHugh, Samantha Orosz, Amanda W Keeler, Sara O'Neal, William C Zamboni, Barbara Davis, Timothy P Coleman
Platinum (Pt) based chemotherapy is widely used to treat many types of cancer. Pt therapy faces challenges such as dose limiting toxicities, cumulative side effects, and multidrug resistance. Nanoemulsions (NEs) have tremendous potential in overcoming these challenges as they can be designed to improve circulation time, limit non-disease tissue uptake, and enhance tumor uptake by surface modification. We designed novel synthesis of three difattyacid platins, dimyrisplatin, dipalmiplatin, and distearyplatin, suitable for encapsulation in the oil core of an NE...
May 24, 2016: Molecular Pharmaceutics
Katharina Sobotta, Kirstin Hillarius, Marvin Mager, Katharina Kerner, Carsten Heydel, Christian Menge
Although domestic ruminants have long been recognized as the main source of human Q fever, little is known about the lifestyle that the obligate intracellular Gram-negative bacterium Coxiella burnetii adopts in its animal host. Because macrophages are considered natural target cells of the pathogen, we established primary bovine monocyte-derived macrophages (MDM) as an in vitro infection model to study reservoir host-pathogen interactions at the cellular level. In addition, bovine alveolar macrophages were included to take cell type peculiarities at a host entry site into account...
June 2016: Infection and Immunity
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