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Jing Zhao, Qiong-Zhu Dong, Fan Zhong, Li-Li Cai, Zhao-Yu Qin, Yang Liu, Cheng-Zhao Lin, Lun-Xiu Qin, Fu-Chu He
Hepatocellular carcinoma (HCC) is one of the most prevalent and aggressive malignant tumors. The involvement of N-myc (and STAT) interactor (NMI) and its possible functional mechanisms in HCC progression still remain to be elucidated. In this study, we found that NMI was overexpressed in metastatic HCC cell lines compared with non-metastatic ones; and the expression levels of NMI in the HCC samples with metastasis were higher than that in the non-metastatic specimens. Furthermore, NMI depletion significantly decreased HCC cell proliferation and invasiveness in vitro, and also inhibited tumor growth and lung metastasis in vivo in nude mice models bearing human HCC...
January 6, 2017: Oncotarget
Fatma Yurt Lambrecht, Kasim Ocakoglu, Suleyman Gokhan Colak, Onur Alp Ersoz, Ozge Er
Imidazolium salts and derivatives have anti-tumor efficacy and toxic effects in different microorganisms. In present study, an imidazolium bromide salt (NMI) was synthesized, and its antitumor potential was investigated by in vitro studies. Radiolabeling of synthesized NMI was carried out by iodogen method using (131) I radionuclide. The yield of radiolabeling was determined as 98.5±0.1%. After that, cytotoxicity and intracellular uptake studies were evaluated in various cell lines. The cytotoxicity of NMI was determined as 35 μM, 20 μM, 10 μM and 1 μM for HEK-293, PC-3, CaCo-2 and MCF-7 cells, respectively...
January 9, 2017: Chemical Biology & Drug Design
Amanda M Farias Zuniga, Julie N Côté
OBJECTIVE: The effects of performing a 90-minute computer task with a laptop versus a dual monitor desktop workstation were investigated in healthy young male and female adults. BACKGROUND: Work-related musculoskeletal disorders are common among computer (especially female) users. Laptops have surpassed desktop computer sales, and working with multiple monitors has also become popular. However, few studies have provided objective evidence on how they affect the musculoskeletal system in both genders...
December 1, 2016: Human Factors
J Neylon, Y Min, K Hasse, D Low, A Santhanam
PURPOSE: Clinical deformable image registration (DIR) accuracy is difficult to quantify, making validation and verification manual and time consuming. It has also been seen that DIR accuracy can be improved by patient and site specific optimization. We previously investigated a cost function to parameterize image similarity metrics (ISMs) and provide a quantifiable comparison of DIR performance. In this abstract, we characterize and optimize the cost function response (CFR) and correlation to target registration error (TRE) in a dense registration parameter space...
June 2016: Medical Physics
S Riyahi, W Choi, N Bhooshan, S Tan, H Zhang, W Lu
PURPOSE: To compare linear and deformable registration methods for evaluation of tumor response to Chemoradiation therapy (CRT) in patients with esophageal cancer. METHODS: Linear and multi-resolution BSpline deformable registration were performed on Pre-Post-CRT CT/PET images of 20 patients with esophageal cancer. For both registration methods, we registered CT using Mean Square Error (MSE) metric, however to register PET we used transformation obtained using Mutual Information (MI) from the same CT due to being multi-modality...
June 2016: Medical Physics
Y Liu, S Stojadinovic, S Jiang, R Timmerman, R Abdulrahman, L Nedzi, X Gu
PURPOSE: Stereotactic radiosurgery (SRS), which delivers a potent dose of highly conformal radiation to the target in a single fraction, requires accurate tumor delineation for treatment planning. We present an automatic segmentation strategy, that synergizes intensity histogram thresholding, super-voxel clustering, and level-set based contour evolving methods to efficiently and accurately delineate SRS brain tumors on contrast-enhance T1-weighted (T1c) Magnetic Resonance Images (MRI)...
June 2016: Medical Physics
James Harvey, Andrew Fleetwood, Ron Ogilvie, Andrew Teasdale, Phil Wilcox, Steven Spanhaak
Management of organic non-mutagenic impurities (NMIs) in medicinal products is regulated by the ICH Q3A, B and C guidelines that are applicable at late stages of clinical development (Phase III onwards) and as a consequence there is no guidance for the assessment and control of NMIs in early clinical trials. An analysis of several key in vivo toxicology databases supports the ICH Q3A defined concept that a lifetime dose to 1 mg/day of a NMI would not represent a safety concern to patients. In conjunction with routine (Q)SAR approaches, this 1 mg/day value could be used as a universal qualification threshold for a NMI during any stage of clinical development...
December 27, 2016: Regulatory Toxicology and Pharmacology: RTP
Jiahao Huang, Pan Xu, Jian Liu, Xiao-Zeng You
Composition engineering of perovskite materials has been demonstrated to be important for high-performance solar cells. Recently, the energy favorable hybridization of formamidinium (FA) and cesium (Cs) in three dimension lead halide perovskites has been attracting increasing attention due to its potential benefit on durability. Herein, we reported a simple and effective method to produce phase-pure CsxFA1-xPbI3 thin film via sequential introduction of cations, in which the FA cation was introduced by interdiffusion annealing in the presence of N-methylimidazole (NMI)...
December 23, 2016: Small
Hossein Arabi, Habib Zaidi
We evaluate the accuracy of whole-body bone extraction from whole-body MR images using a number of atlas-based segmentation methods. The motivation behind this work is to find the most promising approach for the purpose of MRI-guided derivation of PET attenuation maps in whole-body PET/MRI. To this end, a variety of atlas-based segmentation strategies commonly used in medical image segmentation and pseudo-CT generation were implemented and evaluated in terms of whole-body bone segmentation accuracy. Bone segmentation was performed on 23 whole-body CT/MR image pairs via leave-one-out cross validation procedure...
November 12, 2016: Medical Image Analysis
Yan Liu, Strahinja Stojadinovic, Brian Hrycushko, Zabi Wardak, Weiguo Lu, Yulong Yan, Steve B Jiang, Robert Timmerman, Ramzi Abdulrahman, Lucien Nedzi, Xuejun Gu
The objective of this study is to develop an automatic segmentation strategy for efficient and accurate metastatic brain tumor delineation on contrast-enhanced T1-weighted (T1c) magnetic resonance images (MRI) for stereotactic radiosurgery (SRS) applications. The proposed four-step automatic brain metastases segmentation strategy is comprised of pre-processing, initial contouring, contour evolution, and contour triage. First, T1c brain images are preprocessed to remove the skull. Second, an initial tumor contour is created using a multi-scaled adaptive threshold-based bounding box and a super-voxel clustering technique...
December 21, 2016: Physics in Medicine and Biology
Qian Zhang, Lijuan Wang
The most widely used statistical model for conducting moderation analysis is the moderated multiple regression (MMR) model. In MMR modeling, missing data could pose a challenge, mainly because the interaction term is a product of two or more variables and thus is a nonlinear function of the involved variables. In this study, we consider a simple MMR model, where the effect of the focal predictor X on the outcome Y is moderated by a moderator U. The primary interest is to find ways of estimating and testing the moderation effect with the existence of missing data in X...
November 7, 2016: Psychological Methods
Rahul Jain, Tony J Gibson, Mark S Mashuta, Robert M Buchanan, Craig A Grapperhaus
The catalytic aerobic oxidation of benzylic alcohols to corresponding aldehydes has been investigated employing a tetradentate copper(ii) complex that incorporates N-methyl imidazole (NMI) as an integral part of an N4-ligand framework. The complex [L3-Cu](2+) [(L3 = 1-methyl-4,5-dihydro-1H-imidazol-2-yl)methyl(2-ethyl)amine] has been synthesized, characterized by spectroscopic and structural techniques, and its catalytic activity towards the aerobic oxidation of benzylic alcohols studied under ambient conditions...
November 3, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Afshin Samani, Divya Srinivasan, Svend Erik Mathiassen, Pascal Madeleine
The spatio-temporal distribution of muscle activity has been suggested to be a determinant of fatigue development. Pursuing this hypothesis, we investigated the pattern of muscular activity in the shoulder and arm during a repetitive dynamic task performed until participants' rating of perceived exertion reached 8 on Borg's CR-10 scale. We collected high-density surface electromyogram (HD-EMG) over the upper trapezius, as well as bipolar EMG from biceps brachii, triceps brachii, deltoideus anterior, serratus anterior, upper and lower trapezius from 21 healthy women...
October 14, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
Laura Schoenlaub, Rama Cherla, Yan Zhang, Guoquan Zhang
Our recent study demonstrated that virulent Coxiella burnetii Nine Mile phase I (NMI) is capable of infecting and replicating within peritoneal B1a cells and that B1a cells play an important role in host defense against C. burnetii infection in mice. However, it remains unknown if avirulent Nine Mile phase II (NMII) can infect and replicate in B1a cells and whether NMI and NMII can differentially interact with B1a cells. In this study, we examined if NMI and NMII can differentially modulate host cell apoptotic signaling in B1a cells...
December 2016: Infection and Immunity
Manisa Kongkaew, Kannika Sitthisuwannakul, Vasut Nakarajouyphon, Soraya Pornsuwan, Palangpon Kongsaeree, Preeyanuch Sangtrirutnugul
A series of benzimidazole-triazole ligands (NN') having a pendent triazole arm with different triazole substituents including CH2Ph (3a), cyclo-C6H11 (3b), and CH2SiMe3 (3c) were obtained in moderate yields from Cu-catalyzed oxidative C-N cyclization of the respective amine-triazole compounds N,N'-bis((1-R-1,2,3-triazol-4-yl)methyl)benzene-1,2-diamine (2a-2c). Treatment of CuCl2 with one equiv. of the benzimidazole-triazole ligands afforded the corresponding Cu(II) complexes with the empirical formula of Cu(NN')Cl2 (4a-4c)...
September 22, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Shiqing Xu, Ei-Ichi Negishi
Carbometalation of alkenes with stereocontrol offers an important opportunity for asymmetric C-C bond formation. However, the scope of catalytic stereoselective carbometalation of alkenes had until recently been limited to electronically biased alkenes or those with the presence of directing groups or other auxiliary functionalities to overcome the challenge associated with regio- and stereoselectivity. Catalytic asymmetric carbometalation of unactivated alkenes on the other hand remained as a formidable challenge...
October 18, 2016: Accounts of Chemical Research
Keita Matsuura, Masayuki Maeda, Ken-Ichi Tabei, Maki Umino, Hiroyuki Kajikawa, Masayuki Satoh, Hirotaka Kida, Hidekazu Tomimoto
PURPOSE: Neuromelanin-sensitive MR imaging (NMI) is an increasingly powerful tool for the diagnosis of Parkinson's disease (PD). This study was undertaken to evaluate longitudinal changes on NMI in PD patients. METHODS: We examined longitudinal changes on NMI in 14 PD patients. The area and contrast ratio (CR) of the substantia nigra pars compacta (SNc) were comparatively analyzed. RESULTS: The total area and CR of the SNc upon follow-up NMI were significantly smaller than those on initial NMI (from 33...
October 28, 2016: Neuroscience Letters
Ana Rua-Ibarz, Eduardo Bolea-Fernandez, Amund Maage, Sylvia Frantzen, Stig Valdersnes, Frank Vanhaecke
Hg pollution released from the U-864 submarine sunk during WWII and potential introduction of that Hg into the marine food chain have been studied by a combination of quantitative Hg and MeHg determination and Hg isotopic analysis via cold vapor generation multicollector inductively coupled plasma-mass spectrometry (CVG-MC-ICP-MS) in sediment and Cancer pagurus samples. The sediment pollution could be unequivocally linked with the metallic Hg present in the wreck. Crabs were collected at the wreck location and 4 nmi north and south, and their brown and claw meat were analyzed separately...
October 4, 2016: Environmental Science & Technology
N C N Perera, G I Godahewa, Bo-Hye Nam, Jehee Lee
Interferons (IFNs) and IFN-inducible proteins play numerous physiological roles, particularly in antiviral defense mechanisms of the innate immune response with the presence of pathogens. IFN-induced protein-35 kDa (IFP35) is induced by Type II IFN (IFN-γ); it is a cytoplasmic protein that can be translocated to the nucleus via the stimulation of IFN. In this study, we report the complete molecular characterization of the IFP35 cDNA sequence from the black rockfish in an effort to understand its role in the immune response...
September 2016: Fish & Shellfish Immunology
Anne Kuijer, Kay Schreuder, Sjoerd G Elias, Carolien H Smorenburg, Emiel J T Rutgers, Sabine Siesling, Thijs van Dalen
BACKGROUND: Breast cancer guidelines suggest the use of gene expression profiles (GEPs) in estrogen receptor-positive (ER+) breast cancer patients in whom controversy exists regarding adjuvant chemotherapy benefit based on traditional prognostic factors alone. We evaluated the current use of GEPs in these patients in the Netherlands. PATIENTS AND METHODS: Primary breast cancer patients treated between January 1, 2011 and December 31, 2014 and eligible for GEP use according to the Dutch national breast cancer guideline were identified in the Netherlands Cancer Registry: ER+ patients <70 years with grade 1 tumors >2 cm or grade 2 tumors 1-2 cm without overt lymph node metastases (pN0-Nmi)...
2016: Public Health Genomics
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