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Sheffali Gulati, Harsh Patel, Biswaroop Chakrabarty, Rachana Dubey, N K Arora, R M Pandey, Vinod K Paul, Konanki Ramesh, Vyshakh Anand, Ankit Meena
Introduction: There is shortage of specialists for the diagnosis of children with neuromotor impairments (NMIs), especially in resource limited settings. Existing International Clinical Epidemiology Network (INCLEN) instrument for diagnosing NMI have been validated for children aged 2-9 years. The current study modified the same including wider symptomatology and age group (1 month to 18 years). Methods: The Modified INCLEN diagnostic tool (INDT) was developed by a team of experts by modifying the existing tool to widen the age range (1 month to 18 years) and include broader symptomatology (inclusion of milestones from the first 2 years of life and better elucidation of cerebellar and extrapyramidal features) in a tertiary care teaching hospital of North India between January and April 2015...
2017: Frontiers in Public Health
A J Fenwick, J L Wevrett, K M Ferreira, A M Denis-Bacelar, A P Robinson
In External Beam Radiotherapy, National Metrology Institutes (NMIs) play a critical role in the delivery of accurate absorbed doses to patients undergoing treatment. In contrast for nuclear medicine the role of the NMI is less clear and although significant work has been done in order to establish links for activity measurement, the calculation of administered absorbed doses is not traceable in the same manner as EBRT. Over recent decades the use of novel radiolabelled pharmaceuticals has increased dramatically...
November 11, 2017: Applied Radiation and Isotopes
Yu-Hsiang Fu, Chung-Yuan Huang, Chuen-Tsai Sun
The authors use four criteria to examine a novel community detection algorithm: (a) effectiveness in terms of producing high values of normalized mutual information (NMI) and modularity, using well-known social networks for testing; (b) examination, meaning the ability to examine mitigating resolution limit problems using NMI values and synthetic networks; (c) correctness, meaning the ability to identify useful community structure results in terms of NMI values and Lancichinetti-Fortunato-Radicchi (LFR) benchmark networks; and (d) scalability, or the ability to produce comparable modularity values with fast execution times when working with large-scale real-world networks...
2017: PloS One
Jingjing Hou, Shihao Jiang, Jiabao Zhao, Dong Zhu, Xinmeng Zhao, Jian-Chun Cai, Si Qing Zhang
NF-κB is a major regulator of gene transcription involved in immune, inflammation, apoptosis and stress responses. However, the regulation of NF-κB is not completely understood. Here, we report that the N-Myc and STATs Interactor (NMI), an IFN-inducible protein, is an important negative regulator of NF-κB activity. We found that NMI negatively regulates TNF-α-induced IL-6 and IL-1β production in HeLa cells. Overexpression of NMI inhibits NF-κB transcriptional activity, in contrast, depletion of NMI by shRNA increases NF-κB transcriptional activity...
November 6, 2017: Scientific Reports
Ashok Keerthi, Boya Radha, Daniele Rizzo, Hao Lu, Valentin Diez Cabanes, Ian Cheng-Yi Hou, David Beljonne, Jérôme Cornil, Cinzia Casiraghi, Martin Baumgarten, Klaus Müllen, Akimitsu Narita
Edge functionalization of bottom-up synthesized graphene nanoribbons (GNRs) with anthraquinone and naphthalene/perylene monoimide units has been achieved through a Suzuki coupling of polyphenylene precursors bearing bromo groups, prior to the intramolecular oxidative cyclo-dehydrogenation. High efficiency of the substitution has been validated by MALDI-TOF MS analysis of the functionalized precursors and FT-IR, Raman, and XPS analyses of the resulting GNRs. Moreover, AFM measurements demonstrated the modulation of the self-assembling behavior of the edge-functionalized GNRs, revealing that GNR-PMI formed an intriguing rectangular network...
November 9, 2017: Journal of the American Chemical Society
Esther Sok Hwee Cheow, Woo Chin Cheng, Terence Yap, Bamaprasad Dutta, Chuen Neng Lee, Dominique P V de Kleijn, Vitaly Sorokin, Siu Kwan Sze
The lack of precise biomarkers that identify patients at risk for myocardial injury and stable angina delays administration of optimal therapy. Hence, the search for noninvasive biomarkers that could accurately stratify patients with impending heart attack, from patients with stable coronary artery disease (CAD), is urgently needed in the clinic. Herein, we performed comparative quantitative proteomics on whole plasma sampled from patients with stable angina (NMI), acute myocardial infarction (MI), and healthy control subjects (Ctrl)...
November 7, 2017: Journal of Proteome Research
Yi Wang, Ke Chen, Leanne L H Chan
To study the information transmission in the primary visual cortex (V1) of retinal degenerated (RD) models, wild type (WT) and RD rats were used in the experiments. The neural response in V1 was recorded extracellularly while the flicker with varied intensity levels was given as the visual stimulus. The mutual information (MI) and normalized mutual information (NMI) were determined for every isolated neuron, in order to quantify the amount and efficiency of information transmission in V1 of both control and experimental groups...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Adrian Bingham, Sridhar P Arjunan, Dinesh K Kumar
In this study we investigated a technique for estimating the progression of localized muscle fatigue. This technique measures the dependence between motor units using high density surface electromyogram (HD-sEMG) and is based on the Normalized Mutual Information (NMI) measure. The NMI between every pair combination of the electrode array is computed to measure the interactions between electrodes. Participants in the experiment had an array of 64 electrodes (16 by 4) placed over the TA of their dominate leg such that the columns of the array ran parallel with the muscle fibers...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Trieu Phat Luu, Justin A Brantley, Fangshi Zhu, Jose L Contreras-Vidal
This study investigates if the electrocortical amplitude modulations relative to the mean gait cycle are different across walking conditions (i.e., level-ground (LW), ramp ascent (RA), and stair ascent (SA)). Non-invasive electroencephalography (EEG) signals were recorded and a systematic EEG processing method was implemented to reduce artifacts. Source localization using independent component analysis and k-means clustering revealed the involvement of four clusters in the brain (Left and Right Occipital Lobe, Posterior Parietal Cortex (PPC), and Sensorimotor Area) during the walking tasks...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Henry Candra, Mitchell Yuwono, Rifai Chai, Hung T Nguyen, Steven Su
Recognizing emotion from EEG signals is a complicated task that requires complex features and a substantial number of EEG channels. Simple algorithms to analyse the feature and reduce the EEG channel number will give an indispensable advantages. Therefore, this study explores a combination of wavelet entropy and average wavelet coefficient (WEAVE) as a potential EEG-emotion feature to classify valence and arousal emotions with the advantage of the ability to identify the occurrence of a pattern while at the same time identify the shape of a pattern in EEG emotion signal...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Yosra Saidane, Sofia Ben Jebara
This study investigates the effect of preparation warning on the functional connectivity between forearm muscles during movement's initiation. The Normalized Mutual Information (NMI) is the used indicator. It is calculated for muscle pairs activated during a handgrip exercice. They are innervated by the same nerve or by different nerves. Results show that: i) NMI is more important when muscles pairs are stimulated by the same nerve during both preparation and motor activities. ii) NMI is higher during preparation comparing to motor activity...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Zhikai Xiahou, Xiangli Wang, Juan Shen, Xiaoxiao Zhu, Feng Xu, Rong Hu, Deyin Guo, Henan Li, Yong Tian, Yingfang Liu, Huanhuan Liang
Damage-associated molecular patterns (DAMP) trigger innate immune response and exacerbate inflammation to combat infection and cellular damage. Identifying DAMPs and revealing their functions are thus of crucial importance. Here we report that two molecules, N-myc and STAT interactor (NMI) and interferon-induced protein 35 (IFP35) act as DAMPs and are released by activated macrophages during lipopolysaccharide-induced septic shock or acetaminophen-induced liver injury. We show that extracellular NMI and IFP35 activate macrophages to release proinflammatory cytokines by activating nuclear factor-κB through the Toll-like receptor 4 pathway...
October 16, 2017: Nature Communications
Dan Song, Jiabao Zhao, Chen Su, Ying Jiang, Jingjing Hou
Lung carcinoma is one of the leading causes of cancer-related death. The N-Myc and STATs interactor (NMI) has been reported to take participate in lots of physiological processes, but the involvement and functional mechanisms of NMI in lung carcinoma are poorly understood. In this study, we found that etoposide induces proliferation suppression, cell apoptosis and increases caspase-3 activity in A549 cells. Furthermore, etoposide treatment up-regulates the expression of NMI and ARF, enhances the interaction of NMI and ARF and promotes the p53 transcriptional activities...
October 10, 2017: Biochemical and Biophysical Research Communications
Jingshu Wang, Kun Zou, Xu Feng, Miao Chen, Cong Li, Ranran Tang, Yang Xuan, Meihua Luo, Wangbing Chen, Huijuan Qiu, Ge Qin, Yixin Li, Changlin Zhang, Binyi Xiao, Lan Kang, Tiebang Kang, Wenlin Huang, Xinfa Yu, Xiaojun Wu, Wuguo Deng
BACKGROUND: N-myc (and STAT) interactor (NMI) plays vital roles in tumor growth, progression, and metastasis. In this study, we identified NMI as a potential tumor suppressor in lung cancer and explored its molecular mechanism involved in lung cancer progression. METHODS: Human lung cancer cell lines and a mouse xenograft model was used to study the effect of NMI on tumor growth. The expression of NMI, COX-2 and relevant signaling proteins were examined by Western blot...
October 12, 2017: Molecular Cancer
Xiao Xu, Keli Chai, Yuhang Chen, Yongquan Lin, Suzhen Zhang, Xin Li, Wentao Qiao, Juan Tan
N-Myc interactor (Nmi) is reported to participate in many activities, such as signaling transduction, transcription regulation, and antiviral responses. As Nmi may play important roles in interferon (IFN)-induced responses, we investigated the mechanism how Nmi protein is regulated. We identified and cloned the promoter of Nmi gene. Sequence analysis and luciferase assays shown that an IFN-stimulated response element (ISRE) and a GC box in the promoter were essential for the basal transcription activity of Nmi gene...
September 14, 2017: Molecular and Cellular Biochemistry
Leticia Bergamin Januario, Ana Beatriz Oliveira, Marina Machado Cid, Pascal Madeleine, Afshin Samani
PURPOSE: The aim of this study was to evaluate the coordination of the shoulder girdle muscles among subjects with or without neck-shoulder pain performing repetitive arm movement at either a slow or fast pace. METHODS: Thirty female adults were allocated to one of two groups-healthy controls or cases with neck-shoulder pain. Surface electromyography (sEMG) signals from the clavicular, acromial, middle and lower trapezius portions and the serratus anterior muscles were recorded during a task performed for 20min at a slow pace and 20min at a fast pace...
October 2017: Human Movement Science
Laura Facchini, Ilario Losito, Tommaso R I Cataldi, Francesco Palmisano
A systematic characterization of phosphatidylcholines (PC) and phosphatidylethanolamines (PE) in mussels of sp. Mytilus galloprovincialis was performed by high efficiency Hydrophilic Interaction LIquid Chromatography (HILIC) combined with ElectroSpray Ionization (ESI) and Fourier-Transform Mass Spectrometry (FTMS), based on a quadrupole-Orbitrap hybrid spectrometer. FTMS/MS experiments under high-collisional energy dissociation (HCD) conditions, complemented by low energy collisionally induced dissociation (CID) MS(n) (n = 2,3) experiments, performed in a linear ion trap mass spectrometer, were exploited for structural elucidation purposes...
September 11, 2017: Journal of Mass Spectrometry: JMS
Gottfrid Sjödahl
Molecular subtypes of bladder cancer (BC) can be determined by relatively small immunohistochemistry panels both for non-muscle invasive (NMI) and muscle invasive (MI) tumors. For analysis of NMI tumors, as few as two markers are needed, although classification is dependent also on pathological grade and histological evaluation. The result is a classification into the three tumor-cell phenotypes of NMI-BC, Urothelial-like (Uro), Genomically Unstable (GU), and Basal/SCC-like. For analysis of MI tumors, 13 markers are needed...
2018: Methods in Molecular Biology
Xiaofeng Yang, Mylin Torres, Stephanie Kirkpatrick, Walter J Curran, Tian Liu
PURPOSE: Lymphedema, a swelling of the extremity, is a debilitating morbidity of cancer treatment. Current clinical evaluation of lymphedema is often based on medical history and physical examinations, which is subjective. In this paper, the authors report an objective, quantitative 2D strain imaging approach using a hybrid deformable registration to measure soft-tissue stiffness and assess the severity of lymphedema. METHODS: The authors have developed a new 2D strain imaging method using registration of pre- and post-compression ultrasound B-mode images, which combines the statistical intensity- and structure-based similarity measures using normalized mutual information (NMI) metric and normalized sum-of-squared-differences (NSSD), with an affine-based global and B-spline-based local transformation model...
2017: PloS One
Lindie Marais, Jordi Burés, Johan H L Jordaan, Selwyn Mapolie, Andrew J Swarts
Herein a bis(pyridyl)-N-alkylamine/Cu(I)/TEMPO/NMI catalyst system is reported for aerobic oxidation of a variety of primary alcohols to the corresponding aldehydes using readily available reagents, at room temperature and ambient air as the oxidant. ESI-MS analysis of the reaction showed the formation of a [(L1)(NMI)Cu(II)-OOH](+) species, which is a key intermediate in the alcohol oxidation reaction. Evaluation of the effect of reaction parameters on the initial rate of the reaction allowed us to obtain the optimum conditions for catalytic activity...
August 23, 2017: Organic & Biomolecular Chemistry
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