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https://www.readbyqxmd.com/read/29156301/evaluation-of-serum-arsenic-and-its-effects-on-antioxidant-alterations-in-relapsing-remitting-multiple-sclerosis-patients
#1
Kobra Bahrampour Juybari, Ghasem Ebrahimi, Mohammad Amin Momeni Moghaddam, Gholamreza Asadikaram, Masoud Torkzadeh-Mahani, Mahboobeh Akbari, Solmaz Mirzamohammadi, Atieh Karimi, Mohammad Hadi Nematollahi
BACKGROUND: Environmental factors that are involved in the development of autoimmune diseases include bacteria, viruses, and xenobiotics such as chemicals, drugs, and metals. Regarding the metals, a number of studies have demonstrated that oxidative stress is one of the well-directed pathways of arsenic-induced tissue damages. This study was designed to explore the serum concentrations of arsenic and its correlation with markers associated with oxidative stress in relapsing-remitting MS (RRMS) patients...
November 13, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29155752/sagittal-plane-kinematic-gait-analysis-in-c57bl-6-mice-subjected-to-mog35-55-induced-experimental-autoimmune-encephalomyelitis
#2
Maximillian Dj Fiander, Matthew Aj Chedrawe, Anna-Claire Lamport, Turgay Akay, George S Robertson
Kinematic gait analysis in the sagittal plane has frequently been used to characterize motor deficits in multiple sclerosis (MS). We describe the application of these techniques to identify gait deficits in a mouse model of MS, known as experimental autoimmune encephalomyelitis (EAE). Paralysis and motor deficits in mice subjected to EAE are typically assessed using a clinical scoring scale. However, this scale yields only ordinal data that provides little information about the precise nature of the motor deficits...
November 4, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29155646/combination-treatment-of-docosahexaenoic-acid-dha-and-all-trans-retinoic-acid-atra-inhibit-il-17-and-ror%C3%AE-t-gene-expression-in-pbmcs-of-patients-with-relapsing-remitting-multiple-sclerosis
#3
Ateke Mousavi Nasl-Khameneh, Abbas Mirshafiey, Abdorreza Naser Moghadasi, Reza Chahardoli, Maryam Mahmoudi, Karim Parastouei, Mir Saeed Yekaninejad, Ali Akbar Saboor-Yaraghi
OBJECTIVES: Multiple sclerosis (MS) is a demyelinating disorder with a complex autoimmune pathophysiology. Its initiation and progression correlate with IL-17 and the related transcription factor, RORγt. All-trans retinoic acid (ATRA) is a bioactive derivative of vitamin A, and docosahexaenoic acid (DHA) is an active metabolite of omega-3 fatty acid; both have immunomodulatory effects in many immune disorders. This study investigated the effects of DHA and ATRA individually and in combination on IL-17 and RORγt gene expression in peripheral blood mononuclear cells (PBMCs) of relapsing-remitting MS (RRMS) patients who were receiving interferon beta (IFN-β)...
November 18, 2017: Neurological Research
https://www.readbyqxmd.com/read/29155234/survivin-and-autoimmunity-the-ins-and-outs
#4
REVIEW
Hamidreza Ebrahimiyan, Saeed Aslani, Nima Rezaei, Ahmadreza Jamshidi, Mahdi Mahmoudi
Autoimmunity is a status that immune mechanisms react against self-structure. The immune mechanisms, including cellular and molecular elements have been developed to immune body against foreign invades. Multiple factors such as genetic and epigenetic background, hormonal status, microbiome, and other factors can cause launching the autoreactive responses, in which the immune tolerance breaks and immune mechanisms are against self-antigens. Apoptosis is one of the important mechanisms in maintaining the tolerance and eliminating the autoreactive lymphocyte clones...
November 16, 2017: Immunology Letters
https://www.readbyqxmd.com/read/29154721/validating-the-use-of-brain-volume-cutoffs-to-identify-clinically-relevant-atrophy-in-rrms
#5
Francesca Bovis, Nicola De Stefano, Joshua R Steinerman, Volker Knappertz, Maria Pia Sormani
BACKGROUND: Baseline brain volume (BV) is predictive at a group level but is difficult to interpret at the single patient level. OBJECTIVE: To validate BV cutoffs able to identify clinically relevant atrophy in relapsing-remitting multiple sclerosis (RRMS) patients. METHODS: The expected normalized brain volume (NBV) for each patient was calculated using RRMS patients from two phase III clinical trials, applying a linear formula developed on the baseline variable of an independent data set...
November 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29154558/pilot-evaluation-of-a-resilience-training-program-for-people-with-multiple-sclerosis
#6
Kenneth I Pakenham, Matthew Mawdsley, Felicity L Brown, Nicola W Burton
OBJECTIVE: To evaluate the feasibility and psychosocial outcomes of an Acceptance and Commitment Therapy (ACT)-based group resilience training program for people with multiple sclerosis (PwMS). Research Method/Design: The study used a pre-post group intervention design with 3-month follow-up. The intervention consisted of 8 group sessions of 2.5 hours each with 7 weekly sessions plus a booster Session 5 weeks later. Thirty-seven PwMS completed questionnaires. Primary psychosocial outcomes were resilience, quality of life (QoL), and distress...
November 20, 2017: Rehabilitation Psychology
https://www.readbyqxmd.com/read/29154076/multiple-intracerebroventricular-injections-of-human-umbilical-cord-mesenchymal-stem-cells-delay-motor-neurons-loss-but-not-disease-progression-of-sod1g93a-mice
#7
Francesca Sironi, Antonio Vallarola, Martina Bruna Violatto, Laura Talamini, Mattia Freschi, Roberta De Gioia, Chiara Capelli, Azzurra Agostini, Davide Moscatelli, Massimo Tortarolo, Paolo Bigini, Martino Introna, Caterina Bendotti
Stem cell therapy is considered a promising approach in the treatment of amyotrophic lateral sclerosis (ALS) and mesenchymal stem cells (MSCs) seem to be the most effective in ALS animal models. The umbilical cord (UC) is a source of highly proliferating fetal MSCs, more easily collectable than other MSCs. Recently we demonstrated that human (h) UC-MSCs, double labeled with fluorescent nanoparticles and Hoechst-33258 and transplanted intracerebroventricularly (ICV) into SOD1G93A transgenic mice, partially migrated into the spinal cord after a single injection...
November 10, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/29153981/movement-disorders-in-a-cohort-of-algerian-patients-with-multiple-sclerosis
#8
S A Hatteb, S Daoudi
Multiple sclerosis is an inflammatory demyelinating disease of central nervous system. Except for cerebellar tremor, occurence of other movement disorders remains rare. Our study aimed to evaluate their prevalence in our population of patients with multiple sclerosis, and to compare it with literature data. Our results showed higher prevalence compared to European studies, raising the question of mechanisms of the disorder. MRI correlation was also studied, in 3 cases over 8 and a possible correlation was found...
November 16, 2017: Revue Neurologique
https://www.readbyqxmd.com/read/29153910/-multiple-cardiac-rhabdomyomas-revealing-tuberous-sclerosis-in-a-neonate
#9
A Ben Salem, I Mazhoud, F Z Chioukh, R Salem, K Ben Ameur, A Khalfalli, C Hafsa
No abstract text is available yet for this article.
November 16, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29153614/lack-of-cd4-t-cell-percent-decrease-in-alemtuzumab-treated-multiple-sclerosis-patients-with-persistent-relapses
#10
Simona Rolla, Stefania Federica De Mercanti, Valentina Bardina, Dana Horakova, Mario Habek, Ivan Adamec, Eleonora Cocco, Pietro Annovazzi, Anton Vladic, Francesco Novelli, Luca Durelli, Marinella Clerico
Alemtuzumab, a highly effective treatment for relapsing remitting multiple sclerosis (RRMS), induces lymphopenia especially of CD4+ T cells. Here, we report the atypical CD4+ T population behaviour of two patients with persistent disease activity despite repeated alemtuzumab treatments. Whereas lymphocytes count decreased and fluctuated accordingly to alemtuzumab administration, their CD4+ cell percentage was not or just mildly affected and was slightly below the lowest normal limit already before alemtuzumab...
December 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29153612/amelioration-of-ongoing-experimental-autoimmune-encephalomyelitis-with-fluoxetine
#11
Roopa Bhat, Sidharth Mahapatra, Robert C Axtell, Lawrence Steinman
In patients with multiple sclerosis, the selective serotonin reuptake inhibitor, fluoxetine, resulted in less acute disease activity. We tested the immune modulating effects of fluoxetine in a mouse model of multiple sclerosis, i.e. experimental autoimmune encephalomyelitis (EAE). We show that fluoxetine delayed the onset of disease and reduced clinical paralysis in mice with established disease. Fluoxetine had abrogating effects on proliferation of immune cells and inflammatory cytokine production by both antigen-presenting cells and T cells...
December 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29153609/serum-ccl20-and-its-association-with-sirt1-activity-in-multiple-sclerosis-patients
#12
Rui Li, Xiaobo Sun, Yaqing Shu, Yuge Wang, Li Xiao, Zhanhang Wang, Xueqiang Hu, Allan G Kermode, Wei Qiu
CCL20 is a potentially important component in the pathogenesis of multiple sclerosis (MS). SIRT1 exhibits a negative regulatory effect on a variety of inflammatory cytokines and can relieve experimental autoimmune encephalomyelitis. The association between the level of CCL20 and SIRT1 activity in MS patients has not been investigated. In the present study, blood samples were collected from 38 RRMS patients and 40 healthy controls. The serum CCL20 levels were measured by ELISA. SIRT1 activity was evaluated by fluorometric assay...
December 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29153606/pegylated-interferon-beta-in-the-treatment-of-the-theiler-s-murine-encephalomyelitis-virus-mouse-model-of-multiple-sclerosis
#13
Francesca Gilli, Darlene B Royce, Krista D DiSano, Andrew R Pachner
We evaluated the effects of pegylated-interferonβ-1a (pegIFNβ) therapy on intrathecal antibody responses, disability progression, and viral load in the CNS in mice infected with the Theiler's virus (TMEV), an animal model of progressive disability in Multiple Sclerosis (MS). The lack of a direct antiviral activity in the CNS, the absence of any effect upon the intrathecal immune response, and the failure to treat disease progression, indicate that the immunomodulatory effects of pegIFNβ-1a likely occur in the systemic circulation rather than within the CNS...
December 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29153600/subclinical-retinal-atrophy-in-the-unaffected-fellow-eyes-of-multiple-sclerosis-and-neuromyelitis-optica
#14
Tetsuya Akaishi, Kimihiko Kaneko, Noriko Himori, Takayuki Takeshita, Toshiyuki Takahashi, Toru Nakazawa, Masashi Aoki, Ichiro Nakashima
We compared the retinal thickness in the unaffected eyes among the following subtypes of unilateral optic neuritis (ON): multiple sclerosis (MS-ON), neuromyelitis optica spectrum disorder with anti-AQP4 autoantibody (AQP4-ON), patients with serum anti-MOG antibody (MOG-ON), and idiopathic ON. In the chronic phase, macular GCC and circum-papillary RNFL in the unaffected eyes were both atrophied in MS-ON and AQP4-ON, but were not atrophied in the others. Titers of anti-AQP4-Ab was suggested to be associated with such latent neurodegenerative process in AQP4-ON...
December 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29153546/vitamin-d3-supplementation-and-the-il-2-il-2r-pathway-in-multiple-sclerosis-attenuation-of-progressive-disturbances
#15
Linda Rolf, Anne-Hilde Muris, Ruud Theunissen, Raymond Hupperts, Jan Damoiseaux, Joost Smolders
Vitamin D3 upregulates IL-2 receptor alpha (IL2RA, CD25)-expression on CD4(+) T cells in vitro. We investigated effects of 48-weeks vitamin D3 supplements on CD25-expression by CD4(+) T cells of patients with multiple sclerosis (MS). There was no significant difference between the vitamin D3 (n=30) and placebo group (n=23) in IL2RA mRNA-expression by PBMC. Likewise, CD25 cell surface-expression by conventional or regulatory T cells (Treg) did not differ between groups, although Treg CD25-expression and circulating soluble-CD25 levels decreased significantly in the placebo but not vitamin D3-group...
November 10, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29153328/tdp-43-promotes-neurodegeneration-by-impairing-chromatin-remodeling
#16
Amit Berson, Ashley Sartoris, Raffaella Nativio, Vivianna Van Deerlin, Jon B Toledo, Sílvia Porta, Shichong Liu, Chia-Yu Chung, Benjamin A Garcia, Virginia M-Y Lee, John Q Trojanowski, F Brad Johnson, Shelley L Berger, Nancy M Bonini
Regulation of chromatin structure is critical for brain development and function. However, the involvement of chromatin dynamics in neurodegeneration is less well understood. Here we find, launching from Drosophila models of amyotrophic lateral sclerosis and frontotemporal dementia, that TDP-43 impairs the induction of multiple key stress genes required to protect from disease by reducing the recruitment of the chromatin remodeler Chd1 to chromatin. Chd1 depletion robustly enhances TDP-43-mediated neurodegeneration and promotes the formation of stress granules...
November 9, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/29152583/inhibition-of-retrograde-transport-limits-polyomavirus-infection-in-vivo
#17
Saumya Maru, Ge Jin, Dhimant Desai, Shantu Amin, Shwetank, Matthew D Lauver, Aron E Lukacher
Polyomaviruses (PyVs) silently infect most humans, but they can cause life-threatening diseases in immunocompromised individuals. The JC polyomavirus (JCPyV) induces progressive multifocal leukoencephalopathy, a severe demyelinating disease in multiple sclerosis patients receiving immunomodulatory therapy, and BK polyomavirus (BKPyV)-associated nephropathy is a major cause of kidney allograft failure. No effective anti-PyV agents are available. Several compounds have been reported to possess anti-PyV activity in vitro, but none have shown efficacy in clinical trials...
November 2017: MSphere
https://www.readbyqxmd.com/read/29151912/duodenal-angiomyolipoma-with-multiple-systemic-vascular-malformations-and-aneurysms-a-case-report-and-literature-review
#18
Yiqiu Wang, Xiuli Zhang, Peng Liu, Guan Jiang, Wenlou Liu
Angiomyolipomas (AMLs) are barely benign mesenchymal tumors that usually occur in the kidneys and may be associated with tuberous sclerosis complex (TSC). Extrarenal AMLs are markedly rare and infrequently observed in the duodenum. In the present case report, a 22-year-old female patient with duodenal AMLs presenting multiple systemic vascular malformations and aneurysms is described. The patient had a medical history of aneurysm rupture of the right subclavian artery and no other manifestation of TSC. Surgical intervention was performed...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29151517/thrombotic-microangiopathy-presenting-with-intestinal-involvement-following-long-term-interferon-%C3%AE-1b-treatment-for-multiple-sclerosis
#19
Shusaku Omoto, Tomohiro Utsumi, Hiromasa Matsuno, Yuka Terasawa, Yasuyuki Iguchi
Thrombotic microangiopathies (TMAs) are systemic microvascular occlusive disorders. The present report describes a patient with relapsing-remitting multiple sclerosis who had been treated with interferon (IFN)-β1b therapy for eight years and developed TMA. The patient presented with headache, thrombocytopenia, renal dysfunction, severe hypertension, posterior reversible encephalopathy syndrome, and gastrointestinal involvement. After discontinuation of the medication and initiation of antihypertensive treatment, the patient rapidly improved...
November 20, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29151112/phase-difference-enhanced-magnetic-resonance-mr-imaging-padre-technique-for-the-detection-of-age-related-microstructural-changes-in-optic-radiation-comparison-with-diffusion-tensor-imaging-dti
#20
Yasuko Tatewaki, Tatsushi Mutoh, Benjamin Thyreau, Kazuko Omodaka, Takaki Murata, Atsushi Sekiguchi, Toru Nakazawa, Yasuyuki Taki
BACKGROUND The optic radiation (OR) is a white-matter bundle connecting the lateral geniculate body and the visual cortex. Phase difference-enhanced imaging (PADRE) is a new MRI technique that is able to achieve precise delineation of the OR. The aim of this study was to investigate the effect of age on the volume and signal intensity of the OR using PADRE, and to establish a volumetric reference of the OR from a healthy population, compared with diffusion tensor imaging (DTI). MATERIAL AND METHODS Thirty-nine healthy volunteers underwent MR imaging with PADRE and DTI sequences on a 3...
November 19, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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