keyword
https://read.qxmd.com/read/38533498/disease-associated-immune-cell-endotypes-in-anti-mda5-positive-dermatomyositis-using-unbiased-hierarchical-clustering
#1
JOURNAL ARTICLE
Ruru Guo, Yang Yang, Liyang Gu, Xinyu Li, Yiyangzi Ma, Xuesong Liu, Liangjing Lu
OBJECTIVE: Clinical and prognostic features of Anti-MDA5-Positive Dermatomyositis (MDA5+ DM) are diverse. This study aimed to examine the peripheral immune cell profiles of patients with MDA5+ DM, identify disease endotypes related to the heterogeneous manifestations and prognosis, and guide individualized therapy regimen. METHODS: This inpatient cohort included 123 patients with MDA5+ DM. Unsupervised hierarchical clustering analysis was used to derive disease endotypes from the circulating immune cell profiles on admission...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38531645/multifaceted-roles-of-rna-editing-enzyme-adar1-in-innate-immunity
#2
JOURNAL ARTICLE
Inga Jarmoskaite, Jin Billy Li
Innate immunity must be tightly regulated to enable sensitive pathogen detection while averting autoimmunity triggered by pathogen-like host molecules. A hallmark of viral infection, double-stranded RNAs (dsRNAs) are also abundantly encoded in mammalian genomes, necessitating surveillance mechanisms to distinguish 'self' from 'non-self.' ADAR1, an RNA editing enzyme, has emerged as an essential safeguard against dsRNA-induced autoimmunity. By converting adenosines to inosines (A-to-I) in long dsRNAs, ADAR1 covalently marks endogenous dsRNAs, thereby blocking the activation of the cytoplasmic dsRNA sensor MDA5...
March 26, 2024: RNA
https://read.qxmd.com/read/38523968/anti-mda5-antibody-positive-clinically-amyopathic-dermatomyositis-associated-with-multiple-heterologous-carcinomas-a-case-report
#3
Yoshio Nakano, Koji Nishida, Norio Okamoto, Iwao Gohma, Yumiko Yasuhara
Dermatomyositis (DM), an autoimmune disorder, is linked to increased malignancy risk. A 53-year-old man with anti-melanoma differentiation-associated gene 5 (MDA5)-positive clinically amyopathic dermatomyositis (CADM) and rapidly progressing interstitial lung disease (RP-ILD) developed heterochronous gastric and colorectal cancers. Early endoscopic screenings led to successful curative resections, preventing recurrence. Despite low cancer incidence assumptions in patients with anti-MDA5-positive RP-ILD, this case advocates for reevaluation and periodic cancer screenings to enhance management, considering the improved survival with intensive therapy...
February 2024: Curēus
https://read.qxmd.com/read/38522973/a-new-proposal-for-phenotypic-classification-and-outcome-assessment-of-dermatomyositis-based-on-clinical-manifestations-and-serological-testing
#4
JOURNAL ARTICLE
Ting Huang, Ting Ding, Liqing Ding, Shasha Xie, Xiaojing Li, Qiming Meng, Xiaomeng Wu, Hui Luo, Hongjun Zhao
BACKGROUND: Dermatomyositis (DM) is an infrequent disease subgroup of idiopathic inflammatory myopathies characterized by distinct skin lesions. However, high heterogeneity makes clinical diagnosis and treatment of DM very challenging. OBJECTIVES: Unsupervised classification in DM patients and analysis of key factors related to clinical outcomes. METHODS: This retrospective study was conducted between 2017 and 2022 at the Department of Rheumatology, Xiangya Hospital, Central South University...
March 23, 2024: Anais Brasileiros de Dermatologia
https://read.qxmd.com/read/38522030/age-related-transcript-changes-in-type-i-interferon-signaling-in-children-and-adolescents-with-long-covid
#5
JOURNAL ARTICLE
Matteo Fracella, Enrica Mancino, Raffaella Nenna, Chiara Virgillito, Federica Frasca, Alessandra D'Auria, Leonardo Sorrentino, Laura Petrarca, Domenico La Regina, Luigi Matera, Greta Di Mattia, Beniamino Caputo, Guido Antonelli, Alessandra Pierangeli, Raphael P Viscidi, Fabio Midulla, Carolina Scagnolari
SARS-CoV-2 typically causes mild symptoms in children, but evidence suggests that persistent immunopathological changes may lead to long COVID (LC). To explore the interplay between LC and innate immunity, we assessed the type I interferon (IFN-I) response in children and adolescents with LC symptoms (LC; n = 28). This was compared with age-matched SARS-CoV-2 recovered participants without LC symptoms (MC; n = 28) and healthy controls (HC; n = 18). We measured the mRNA expression of IFN-I (IFN-α/β/ε/ω), IFN-I receptor (IFNAR1/2), and ISGs (ISG15, ISG56, MxA, IFI27, BST2, LY6E, OAS1, OAS2, OAS3, and MDA5) in PBMCs collected 3-6 months after COVID-19...
March 24, 2024: European Journal of Immunology
https://read.qxmd.com/read/38515992/a-less-common-case-of-anti-mda5-and-anti-ro52-antibody-positive-juvenile-dermatomyositis-complicated-with-macrophage-activation-syndrome
#6
Li Zhang, Haiqing Zhang, Shanshan Liu, Ning Zhang, Yun Wang
No abstract text is available yet for this article.
March 2024: Clinical Case Reports
https://read.qxmd.com/read/38514155/treatment-of-myopathy-and-cutaneous-ulcers-in-anti-mda5-positive-dermatomyositis-with-triple-therapy
#7
JOURNAL ARTICLE
Gopisree Peringeth, Bhavna Abbi, Shereen Mahmood
Antimelanoma differentiation-associated protein 5 positive dermatomyositis (MDA5 DM) is a rare subtype of idiopathic inflammatory myopathy. There are limited data available regarding the cutaneous manifestations of MDA5 DM in the African American population. We presented the case of a male patient in his early 20s who presented with debilitating cutaneous ulceration and myopathy. Workup revealed interstitial lung disease (ILD) and positive MDA5 serology consistent with MDA5 DM. He made a remarkable recovery in terms of myopathy and cutaneous ulcerations with a multipronged regimen of prednisone, intravenous immunoglobulin and mycophenolate mofetil...
March 21, 2024: BMJ Case Reports
https://read.qxmd.com/read/38512977/a-genome-wide-crispr-screening-uncovers-that-tob1-acts-as-a-key-host-factor-for-fmdv-infection-via-both-ifn-and-egfr-mediated-pathways
#8
JOURNAL ARTICLE
Gaochuang Peng, Tianran Liu, Xiaolan Qi, Yuzhe Wang, Jingjing Ren, Jiangling Peng, Xuguang Du, Siyu Hu, Sen Wu, Yaofeng Zhao, Dan Li, Haixue Zheng
The interaction between foot-and-mouth disease virus (FMDV) and the host is extremely important for virus infection, but there are few researches on it, which is not conducive to vaccine development and FMD control. In this study, we designed a porcine genome-scale CRISPR/Cas9 knockout library containing 93,859 single guide RNAs targeting 16,886 protein-coding genes, 25 long ncRNAs, and 463 microRNAs. Using this library, several previously unreported genes required for FMDV infection are highly enriched post-FMDV selection in IBRS-2 cells...
March 21, 2024: PLoS Pathogens
https://read.qxmd.com/read/38507703/the-clinical-relevance-of-wdfy4-in-autoimmune-diseases-in-diverse-ancestral-populations
#9
JOURNAL ARTICLE
Xia Lyu, Janine A Lamb, Hector Chinoy
WD repeat- and FYVE domain-containing protein 4 (WDFY4), coded by a gene on 10q11.23, is a member of the BEACH (Beige and Chediak-Higashi) domain-containing family. Genome-wide association studies identified WDFY4 variants as a risk factor for SLE in Asian and European populations. WDFY4 variants are also associated with RA and primary biliary cholangitis, in different ancestry populations. The WDFY4 protein plays an essential role in the cross-presentation of classic dendritic cells, reactive oxygen species-induced apoptosis of CD8+ T cells, and non-canonical autophagic activity in B cells...
March 20, 2024: Rheumatology
https://read.qxmd.com/read/38495345/involvement-of-retinoic-acid%C3%A2-inducible-gene%C3%A2-i-in-radiation%C3%A2-induced-senescence-of-human-umbilical-vein-endothelial-cells
#10
JOURNAL ARTICLE
Fuki Sasaki, Hironori Yoshino, Ayumu Kusuhara, Kota Sato, Eichi Tsuruga
In 2012, the threshold radiation dose (0.5 Gy) for cardiovascular and cerebrovascular diseases was revised, and this threshold dose may be exceeded during procedures involving radiation such as interventional radiology. Therefore, in addition to regulating radiation dose, it is necessary to develop strategies to prevent and mitigate the development of cardiovascular disease. Cellular senescence is irreversible arrest of cell proliferation. Although cellular senescence is one of the mechanisms for suppressing cancer, it also has adverse effects...
April 2024: Biomedical Reports
https://read.qxmd.com/read/38488091/clinical-histologic-and-prognostic-features-of-clinically-amyopathic-dermatomyositis
#11
JOURNAL ARTICLE
Marco Fornaro, Francesco Girolamo, Margherita Giannini, Laura Coladonato, Adriana Capuano, Marco Capodiferro, Dario D'Abbicco, Maddalena Ruggieri, Mariangela Mastrapasqua, Florenzo Iannone
OBJECTIVES: To characterise clinical amyopathic dermatomyositis (CADM) from a clinical, histological, and prognostic perspective. METHODS: We retrospectively recorded data from our DM cohort. Patients were categorised into three groups: classic DM, hypomyopathic DM (HDM), characterised by normal muscle strength and evidence of muscle involvement in laboratory tests and/or instrumental examinations and CADM, featured by normal muscle strength and unremarkable findings in both laboratory tests and instrumental examinations...
February 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38487540/the-ifih1-a946t-risk-variant-promotes-diabetes-in-a-sex-dependent-manner
#12
JOURNAL ARTICLE
Amanda J Stock, Pierina Gonzalez Paredes, Luciana Previato de Almeida, Stanley D Kosanke, Srinivaas Chetlur, Hannah Budde, Paul Wakenight, Theresa A Zwingman, Aaron B I Rosen, Eric J Allenspach, Kathleen J Millen, Jane H Buckner, David J Rawlings, Jacquelyn A Gorman
Type 1 diabetes (T1D) is an autoimmune disease in which pancreatic islet β-cells are attacked by the immune system, resulting in insulin deficiency and hyperglycemia. One of the top non-synonymous single-nucleotide polymorphisms (SNP) associated with T1D is in the interferon-induced helicase C domain-containing protein 1 ( IFIH1 ), which encodes an anti-viral cytosolic RNA sensor. This SNP results in an alanine to threonine substitution at amino acid 946 ( IFIH1A946T ) and confers an increased risk for several autoimmune diseases, including T1D...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38479813/assessing-the-sensitivity-and-specificity-of-myositis-specific-and-associated-autoantibodies-a-sub-study-from-the-myocite-cohort
#13
JOURNAL ARTICLE
Aravinthan Loganathan, Latika Gupta, Alex Rudge, Hui Lu, Elizabeth Bowler, Fionnuala McMorrow, R Naveen, Anamika K Anuja, Vikas Agarwal, Neil McHugh, Sarah Tansley
OBJECTIVES: Myositis-specific and associated autoantibodies are important biomarkers in routine clinical use. We assessed local testing performance for myositis autoantibodies by comparing line immunoassay (LIA) to protein radio-immunoprecipitation and identifying clinical characteristics associated with each myositis autoantibody in the MyoCite cohort. METHODS: Serum samples from patients within the MyoCite cohort, a well-characterised retro-prospective dataset of adult and juvenile idiopathic inflammatory myopathy (IIM) patients in Lucknow, India (2017-2020), underwent LIA at Sanjay Gandhi Postgraduate Institute of Medical Science (SGPGIMS), Lucknow...
March 13, 2024: Rheumatology
https://read.qxmd.com/read/38465233/picornavirus-2c-proteins-structure-function-relationships-and-interactions-with-host-factors
#14
REVIEW
Chunhui Yin, Haomiao Zhao, Xiaoyi Xia, Zhengyang Pan, Daoqun Li, Leiliang Zhang
Picornaviruses, which are positive-stranded, non-enveloped RNA viruses, are known to infect people and animals with a broad spectrum of diseases. Among the nonstructural proteins in picornaviruses, 2C proteins are highly conserved and exhibit multiple structural domains, including amphipathic α-helices, an ATPase structural domain, and a zinc finger structural domain. This review offers a comprehensive overview of the functional structures of picornaviruses' 2C protein. We summarize the mechanisms by which the 2C protein enhances viral replication...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38464459/dermatomyositis-practical-guidance-and-unmet-needs
#15
REVIEW
Lydia Cassard, Noelle Seraly, Maureen Riegert, Aditi Patel, Anthony P Fernandez
Dermatomyositis is a heterogeneous idiopathic inflammatory myopathy associated with various cutaneous manifestations and variable presence of myositis, interstitial lung disease, and other visceral organ involvement. An accurate diagnosis of dermatomyositis requires correlating clinical examination findings with serological and histological findings. Familiarity with pathognomonic and common cutaneous manifestations of dermatomyositis, which are highlighted here, can be especially helpful in making an accurate diagnosis...
2024: ImmunoTargets and Therapy
https://read.qxmd.com/read/38460305/mavs-promotes-interferon-signaling-in-rna-virus-infection-by-zufsp-mediated-chromatin-regulation
#16
JOURNAL ARTICLE
Tongyu Li, Siji Li
Mitochondria serve as a platform for innate immune signaling transduction, and mitochondrial antiviral signaling protein (MAVS) is essential for interferon-β (IFN-β) production and innate antiviral immunity against RNA viruses. Here, we identified zinc finger-containing ubiquitin peptidase 1 (ZUFSP/ZUP1) as a MAVS-interacting protein by using proximity-based labeling technology in HEK293T and found it could act as a positive regulator of the retinoic acid-inducible gene-I (RIG-I)-like receptors(RLRs), including RIG-I and interferon-induced helicase C domain-containing protein 1 (MDA5)...
March 8, 2024: International Immunopharmacology
https://read.qxmd.com/read/38456909/baricitinib-for-anti-melanoma-differentiation-associated-protein-5-antibody-positive-dermatomyositis-associated-interstitial-lung-disease-a-case-series-and-literature-review-on-janus-kinase-inhibitors-for-the-disease
#17
REVIEW
Hiroaki Harada, Hirofumi Shoda, Haruka Tsuchiya, Makoto Misaki, Takayuki Sawada, Keishi Fujio
Anti-melanoma differentiation-associated protein 5 antibody-positive dermatomyositis (anti-MDA5-DM) is frequently complicated by progressive interstitial lung disease (ILD), the prognosis of which is poor, and management is a major challenge. We treated three patients with anti-MDA5-DM-associated ILD (anti-MDA5-DM-ILD) using the Janus kinase (JAK) inhibitor, baricitinib, which improved lung opacities and saved two patients. We reviewed 6 patients with anti-MDA5-DM-ILD who had been treated with tofacitinib at our institution...
March 8, 2024: Rheumatology International
https://read.qxmd.com/read/38438020/role-of-long-non-coding-rna-dly6e-in-regulating-tmuv-infection
#18
JOURNAL ARTICLE
Siming Zhu, Xin Chen, Dalin He, Meijuan Zhang, Xinhong Man, Yi Tang, Youxiang Diao
Long non-coding RNA (lncRNA) is a type of RNA with a length greater than 200 nt and lacking coding ability. In recent years, a considerable number of lncRNAs have been found to have important functions. The lncRNA plays an important role in growth and development, body metabolism, immune function, and regulation of viral replication. A lncRNA, MSTRG8505.2, was screened and named lncRNA DLY6E, which was a new duck-derived lncRNA. The lncRNADLY6E in this study has a complex secondary structure, specifically distributed in the heart, liver and other organs...
March 2, 2024: Virus Research
https://read.qxmd.com/read/38436114/clinical-and-immunological-features-of-covid-19-in-patients-with-anti-mda5-dermatomyositis-during-the-omicron-wave-in-chongqing-china
#19
JOURNAL ARTICLE
Na Wu, Zhiwei Chen, Guanhua Zha, Zhiling Deng, Wenhan Huang, Dachuan Cai, Mingli Peng, Peng Hu, Lin Tang, Hong Ren
Patients with anti-melanoma differentiation-associated gene 5 (anti-MDA5) dermatomyositis (DM) have a higher risk of coronavirus disease 2019 (COVID-19) infection. In this longitudinal observational study, we aimed to investigate the clinical and immunological features of these patients after COVID-19 infection. A total of 73 patients with anti-MDA5 DM were recruited from the Second Affiliated Hospital of Chongqing Medical University during the Omicron wave epidemic. Clinical data were collected by questionnaire survey and electronic medical records...
March 2024: Journal of Medical Virology
https://read.qxmd.com/read/38432272/melanoma-differentiation-associated-protein-5-prevents-cardiac-hypertrophy-via-apoptosis-signal-regulating-kinase-1-c-jun-n-terminal-kinase-p38-signaling
#20
JOURNAL ARTICLE
Bin-Bin Du, Hui-Ting Shi, Li-Li Xiao, Ya-Peng Li, Rui Yao, Cui Liang, Xiao-Xu Tian, Lu-Lu Yang, Ling-Yao Kong, Jia-Qi Du, Zhao-Zhi Zhang, Yan-Zhou Zhang, Huang Zhen
Pathological cardiac hypertrophy (CH) is driven by maladaptive changes in myocardial cells in response to pressure overload or other stimuli. CH has been identified as a significant risk factor for the development of various cardiovascular diseases, ultimately resulting in heart failure. Melanoma differentiation-associated protein 5 (MDA5), encoded by interferon-induced with helicase C domain 1 (IFIH1), is a cytoplasmic sensor that primarily functions as a detector of double-stranded ribonucleic acid (dsRNA) viruses in innate immune responses; however, its role in CH pathogenesis remains unclear...
March 1, 2024: International Journal of Biological Macromolecules
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