keyword
MENU ▼
Read by QxMD icon Read
search

interferon lambda

keyword
https://www.readbyqxmd.com/read/28122304/synergy-with-interferon-lambda-3-and-sorafenib-suppresses-hepatocellular-carcinoma-proliferation
#1
Yuke Yan, Liang Wang, Jingjing He, Pengcheng Liu, Xi Lv, Yawu Zhang, Xiaodong Xu, Lingyi Zhang, Youcheng Zhang
Hepatocellular carcinoma (HCC) is a common and fatal malignancy of the liver. Sorafenib is a small molecule multikinase inhibitor that acts against different cancer cell lines and is used for the treatment of HCC. However, some advanced HCC patients fail to respond to sorafenib, and those who do lack a meaningful clinical benefit. Interferon-lambda 3 (IFN-λ3) is a type III interferon with antiviral, antiproliferative, and immunomodulatory functions. Here, we evaluated the use of IFN-λ3 as an adjuvant treatment with sorafenib in HCC...
January 22, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28109912/ifn-lambda-preferably-inhibits-pedv-infection-of-porcine-intestinal-epithelial-cells-compared-with-ifn-alpha
#2
Lin Li, Fang Fu, Mei Xue, Weiye Chen, Jin Liu, Hongyan Shi, Jianfei Chen, Zhigao Bu, Li Feng, Pinghuang Liu
In contrast to type I interferons that target various types of cells and organs, interferon lambda (IFN-L) primarily acts on mucosal epithelial cells and exhibits robust antiviral activity within the mucosal surface. Porcine epidemic diarrhea virus (PEDV), which causes high morbidity and mortality in piglets, is an enteropathogenic coronavirus with economic importance. Here, we demonstrated that both recombinant porcine IFN-L1 (rpIFN-L1) and rpIFN-L3 have powerful antiviral activity against PEDV infection of both Vero E6 cells and the intestinal porcine epithelial cell line J2 (IPEC-J2)...
January 19, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28077655/expression-of-ifnlr1-on-intestinal-epithelial-cells-is-critical-to-the-antiviral-effects-of-ifn-lambda-against-norovirus-and-reovirus
#3
Megan T Baldridge, Sanghyun Lee, Judy J Brown, Nicole McAllister, Kelly Urbanek, Terence S Dermody, Timothy J Nice, Herbert W Virgin
: Interferon-lambda (IFN-λ) has potent antiviral effects against multiple enteric viral pathogens, including norovirus and rotavirus, in both preventing and curing infection. Because the intestine includes a diverse array of cell types, however, the cell(s) upon which IFN-λ acts to exert its antiviral effects are unclear. Here, we sought to identify IFN-λ responsive cells by generation of mice with lineage-specific deletion of the receptor for IFN-λ, Ifnlr1 We found that expression of IFNLR1 on intestinal epithelial cells (IECs) in the small intestine and colon is required for enteric IFN-λ antiviral activity...
January 11, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28036111/hepatic-ifnl4-expression-is-associated-with-non-response-to-interferon-based-therapy-through-the-regulation-of-basal-interferon-stimulated-gene-expression-in-chronic-hepatitis-c-patients
#4
Miyako Murakawa, Yasuhiro Asahina, Fukiko Kawai-Kitahata, Mina Nakagawa, Sayuri Nitta, Satoshi Otani, Hiroko Nagata, Shun Kaneko, Yu Asano, Tomoyuki Tsunoda, Masato Miyoshi, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Yasuhito Tanaka, Sayuki Iijima, Kaoru Tsuchiya, Namiki Izumi, Shuju Tohda, Mamoru Watanabe
Single nucleotide polymorphisms (SNPs) within or near interferon lambda 4 (IFNL4) gene located upstream of IFNL3 are associated with response to anti-HCV therapy both in interferon (IFN)-based and IFN-free regimens. IFNL4 encodes IFNλ4, a newly discovered type III IFN, and its expression is controlled by rs368234815-TT/ΔG, which is in strong linkage disequilibrium (LD) with other tag SNPs within or near IFNL4 such as rs12979860 and rs8099917. Intrahepatic expression levels of IFN-stimulated genes (ISGs) affect the responsiveness to IFNα and are also associated with IFNL4 genotype...
December 30, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27986689/hla-b-57-and-ifnl4-related-polymorphisms-are-associated-with-protection-against-hiv-1-disease-progression-in-controllers
#5
B Dominguez-Molina, L Tarancon-Diez, S Hua, C Abad-Molina, E Rodriguez-Gallego, K Machmach, F Vidal, C Tural, S Moreno, J M Goñi, E Ramírez de Arellano, M Del Val, M F Gonzalez-Escribano, J Del Romero, C Rodriguez, L Capa, P Viciana, J Alcamí, X G Yu, B D Walker, Leal M, M Lichterfeld, E Ruiz-Mateos
BACKGROUND: HIV-1-controllers maintain HIV-1 viremia at low levels (normally <2000 HIV-RNA copies/mL) without antiretroviral treatment. However, some HIV-1-controllers have evidence of immunologic progression with marked CD4(+)T-cell decline. We investigated host genetic factors associated with protection against CD4(+)T-cell loss in HIV-1-controllers. METHODS: We analysed the association of interferon lambda 4 (IFNL4)-related polymorphisms and HLA-B haplotypes within Long Term Non-Progressor HIV-1-controllers ((LTNP-C), defined by maintaining CD4(+)T-cells counts >500 cells/mm(3) for more than 7 years after HIV-1 diagnosis) versus non-LTNP-C, who developed CD4(+)T-cells counts <500 cells/mm(3) Both a Spanish study cohort (n=140) and an international validation cohort (n=914) were examined...
December 16, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27904617/the-interferon-lambda-4-rs368234815-predicts-treatment-response-to-pegylated-interferon-alpha-and-ribavirin-in-hemophilic-patients-with-chronic-hepatitis-c
#6
Maryam Keshvari, Seyed Moayed Alavian, Bita Behnava, Ali Pouryasin, Heidar Sharafi
BACKGROUND: A dinucleotide variant rs368234815 in interferon lambda 4 (IFNL4) gene was recently found to be associated with the hepatitis C virus (HCV) treatment response. This study aimed to assess the impact of IFNL4 rs368234815 polymorphism on treatment response to pegylated-IFN alpha (Peg-IFN-α) and ribavirin (RBV) in hemophilic patients with chronic hepatitis C (CHC). MATERIALS AND METHODS: In this retrospective study, 92 hemophilic patients with CHC who were treated with Peg-IFN-α/RBV were investigated...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27844277/chronic-hepatitis-c-virus-infection-in-india-regional%C3%A2-demographics-and-distribution-of-viral-genotypes
#7
Samir R Shah, P N Rao, Shiv K Sarin, Abhijit Chowdhury, Shobna Bhatia, Rajesh Dharamsi, B D Goswami, Dharmesh Kapoor, Rosang Luaia, Rajiv Mehta, Shrikant Mukewar, V G Mohan Prasad, Ramesh Roop Rai, Sanjiv Saigal, Devendra Singh, Nirupama Trehanpati, Sandra Chen, Anuj Gaggar, Steven J Knox, G Mani Subramanian, Shivaram Prasad Singh, Ajit Sood, Joy Varghese, Raj Vigna Venugopal
BACKGROUND AND AIMS: Although chronic hepatitis C virus (HCV) infection affects millions of people in India, few studies have assessed host, viral, and disease characteristics of chronically infected patients at national and regional levels. Such information is critical to support large scale screening and treatment initiatives for chronic HCV infection in India. METHODS: Patients with known chronic HCV infection making routine or for-cause visits to the participating study centers were enrolled in this observational study...
November 2016: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/27833958/clinical-importance-of-pharmacogenetics-in-the-treatment-of-hepatitis-c-virus-infection
#8
Adina Maria Kamal, Paul MitruŢ, Kamal Constantin Kamal, Oana Sorina Tica, Mihaela Niculescu, Dragoş Ovidiu Alexandru, Andrei Adrian Tica
Globally, over 4% of the world population is affected by hepatitis C virus (HCV) infection. The current standard of care for hepatitis C infection is combination therapy with pegylated interferon and ribavirin for 48 weeks, which yield a sustained virological response in only a little over half of the patients with genotype 1 HCV. We investigated the clinical importance of pharmacogenetics in treatment efficacy and prediction of hematotoxicity. A total of 148 patients infected with HCV were enrolled. All patients were treated for a period of 48 weeks or less with pegylated interferon and ribavirin...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27826322/daclatasvir-based-treatment-regimens-for-hepatitis-c-virus-infection-a-systematic-review-and-meta-analysis
#9
REVIEW
Seyed Moayed Alavian, Mohammad Saeid Rezaee-Zavareh
CONTEXT: Direct acting antivirals (DAAs) have recently emerged as a promising therapeutic regimen for the treatment of hepatitis C virus (HCV) infection, which is a major public health problem. Among the known DAAs, daclatasvir (DCV), an inhibitor of the non-structural 5A protein, has been used in combination with several drugs for treatment of infection with HCV of different genotypes under different conditions. We conducted a systematic review and meta-analysis of combination therapy with DCV...
September 2016: Hepatitis Monthly
https://www.readbyqxmd.com/read/27810523/correlation-of-interferon-lambda-4-ss469415590-with-the-hepatitis-c-virus-treatment-response-and-its-comparison-with-interleukin-28b-polymorphisms-in-predicting-a-sustained-virological-response-a-meta-analysis
#10
Yunhua Li, Luhua Yang, Kaihui Sha, Tonggang Liu, Liguo Zhang
BACKGROUND: Interferon-lambda 4 (IFNL4) ss469415590 is a newly discovered polymorphism that could predict the treatment response in hepatitis C virus (HCV)-infected patients. This meta-analysis was performed in order to clarify its specific effect on the treatment response and to compare it with interleukin 28b (IL28B). METHOD: The commonly used literature databases were searched. Meta-analyses were performed with fixed/random-effects models using Stata 12.0. The sustained virological response (SVR) rate was summarized using R software...
December 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27799623/interferon-lambda-4-expression-is-suppressed-by-the-host-during-viral-infection
#11
MeeAe Hong, Johannes Schwerk, Chrissie Lim, Alison Kell, Abigail Jarret, Joseph Pangallo, Yueh-Ming Loo, Shuanghu Liu, Curt H Hagedorn, Michael Gale, Ram Savan
Interferon (IFN) lambdas are critical antiviral effectors in hepatic and mucosal infections. Although IFNλ1, IFNλ2, and IFNλ3 act antiviral, genetic association studies have shown that expression of the recently discovered IFNL4 is detrimental to hepatitis C virus (HCV) infection through a yet unknown mechanism. Intriguingly, human IFNL4 harbors a genetic variant that introduces a premature stop codon. We performed a molecular and biochemical characterization of IFNλ4 to determine its role and regulation of expression...
November 14, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27773202/a-single-nucleotide-polymorphism-rs12979860-in-the-non-coding-control-region-of-the-interferon-lambda-gene-cluster-may-affect-the-relative-expression-of-interferon-lambda-2-and-lambda-3
#12
https://www.readbyqxmd.com/read/27749900/a-randomized-study-of-peginterferon-lambda-1a-compared-to-peginterferon-alfa-2a-in-combination-with-ribavirin-and-telaprevir-in-patients-with-genotype-1-chronic-hepatitis-c
#13
Robert Flisiak, Mitchell Shiffman, Juan Arenas, Hugo Cheinquer, Igor Nikitin, Yuping Dong, Khurram Rana, Subasree Srinivasan
BACKGROUND: A randomized, double-blind, multinational, phase 3 study was conducted comparing the efficacy and safety of peginterferon lambda-1a (Lambda)/ribavirin (RBV)/telaprevir (TVR) vs. peginterferon alfa-2a (Alfa)/RBV/TVR in patients with chronic hepatitis C virus (HCV) genotype-1 (GT-1) infection. METHODS: Patients (treatment-naïve or relapsers on prior Alfa/RBV treatment) were randomly assigned in a 2:1 ratio to receive Lambda/RBV/TVR or Alfa/RBV/TVR. Total duration of treatment was either 24 or 48 weeks (response-guided treatment), with TVR administered for the first 12 weeks...
2016: PloS One
https://www.readbyqxmd.com/read/27735085/impact-of-ifnl4-rs12979860-and-rs8099917-polymorphisms-on-response-to-peg-interferon-%C3%AE-and-ribavirin-in-patients-with-congenital-bleeding-disorder-and-chronic-hepatitis-c
#14
Maryam Keshvari, Seyed Moayed Alavian, Bita Behnava, Ali Pouryasin, Johanna C Craig, Heidar Sharafi
BACKGROUND: The aim of this study was to determine whether two polymorphisms of the human interferon lambda 4 (IFNL4) gene (rs12979860 and rs8099917) can predict sustained virologic response (SVR) following antiviral therapy in patients with inherited bleeding disorder and chronic hepatitis C (CHC). METHODS: This retrospective study was conducted on 294 patients with congenital bleeding disorder and CHC who were treated with Peg-Interferon-α (PegIFN) and Ribavirin (RBV)...
October 13, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27632156/the-superiority-of-ifn-%C3%AE-as-a-therapeutic-candidate-to-control-acute-influenza-viral-lung-infection
#15
Sujin Kim, Min-Ji Kim, Chang-Hoon Kim, Ju Wan Kang, Ha Kyung Shin, Dong-Young Kim, Tae-Bin Won, Doo Hee Han, Chae Seo Rhee, Joo-Heon Yoon, Hyun Jik Kim
Here, we studied the IFN-regulated innate immune response against influenza A virus (IAV) infection in the mouse lung and the therapeutic effect of IFN-λ2/3 in acute IAV lung infection. For viral infections, IAV (WS/33, H1N1, PR8 H1N1, H5N1) were inoculated into wild-type mice by intranasal delivery, and IAV mRNA level and viral titer were measured. To compare the antiviral effect of IFNs in vivo in the lung, neutralizing antibodies and recombinant IFNs were used. After intranasal inoculation of IAV into mice, viral infection peaked at 7 days postinfection, and the IAV titer also reached its peak at this time...
February 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/27617757/immune-cell-profiling-of-ifn-%C3%AE-response-shows-pdcs-express-highest-level-of-ifn-%C3%AE-r1-and-are-directly-responsive-via-the-jak-stat-pathway
#16
Aoife Kelly, Mark W Robinson, Gerard Roche, Christine A Biron, Cliona O'Farrelly, Elizabeth J Ryan
The interferon lambda (IFN-λ) cytokines have well-known antiviral properties, yet their contribution to immune regulation is not well understood. Epithelial cells represent the major target cell of IFN-λ; peripheral blood mononuclear cells are generally considered nonresponsive, with the exception of plasmacytoid dendritic cells (pDCs). In this study we aimed to define the potential for discrete subpopulations of cells to directly respond to IFN-λ. Analysis of peripheral blood leukocytes reveals that, while pDCs uniformly express the highest levels of IFN-λ receptor, a small proportion of B cells and monocytes also express the receptor...
December 2016: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/27588258/a-randomized-controlled-study-of-peginterferon-lambda-1a-ribavirin%C3%A2-%C3%A2-%C3%A2-daclatasvir-for-hepatitis-c-virus-genotype-2-or-3
#17
Graham R Foster, Kazuaki Chayama, Wan-Long Chuang, Hugo Fainboim, Martti Farkkila, Adrian Gadano, Giovanni B Gaeta, Christophe Hézode, Yukiko Inada, Jeong Heo, Hiromitsu Kumada, Sheng-Nan Lu, Patrick Marcellin, Christophe Moreno, Stuart K Roberts, Simone I Strasser, Alexander J Thompson, Joji Toyota, Seung Woon Paik, John M Vierling, Anna L Zignego, David Cohen, Fiona McPhee, Megan Wind-Rotolo, Subasree Srinivasan, Matthew Hruska, Heather Myler, Simon D Portsmouth
BACKGROUND AND PURPOSE: Peginterferon Lambda was being developed as an alternative to alfa interferon for the treatment of chronic hepatitis C virus (HCV) infection. We compared peginterferon Lambda-1a plus ribavirin (Lambda/RBV) and Lambda/RBV plus daclatasvir (DCV; pangenotypic NS5A inhibitor) with peginterferon alfa-2a plus RBV (alfa/RBV) in treatment-naive patients with HCV genotype 2 or 3 infection. METHODS: In this multicenter, double-blind, phase 3 randomized controlled trial, patients were assigned 2:2:1 to receive 24 weeks of Lambda/RBV, 12 weeks of Lambda/RBV + DCV, or 24 weeks of alfa/RBV...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27560987/interferon-lambda-4-ifnl4-gene-polymorphism-is-associated-with-spontaneous-clearance-of-hcv-in-hiv-1-positive-patients
#18
Camila Fernanda da Silveira Alves, Camila Schultz Grott, Vagner Ricardo Lunge, Jorge Umberto Béria, Daniela Cardoso Tietzmann, Airton Tetelbom Stein, Daniel Simon
Approximately one-third of the individuals infected with human immunodeficiency virus type 1 (HIV-1) are co-infected with hepatitis C virus (HCV). Co-infected patients have an increased risk for developing end-stage liver diseases. Variants upstream of the IFNL3 gene have been associated with spontaneous and treatment-induced clearance of HCV infection. Recently, a novel polymorphism was discovered, denoted IFNL4 ΔG > TT (rs368234815), which seems to be a better predictor of spontaneous clearance than the IFNL4 rs12979860 polymorphism...
July 2016: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/27459258/interferon-lambda-4-ifnl4-gene-polymorphism-is-associated-with-spontaneous-clearance-of-hcv-in-hiv-1-positive-patients
#19
Camila Fernanda da Silveira Alves, Camila Schultz Grott, Vagner Ricardo Lunge, Jorge Umberto Béria, Daniela Cardoso Tietzmann, Airton Tetelbom Stein, Daniel Simon
Approximately one-third of the individuals infected with human immunodeficiency virus type 1 (HIV-1) are co-infected with hepatitis C virus (HCV). Co-infected patients have an increased risk for developing end-stage liver diseases. Variants upstream of the IFNL3 gene have been associated with spontaneous and treatment-induced clearance of HCV infection. Recently, a novel polymorphism was discovered, denoted IFNL4 ΔG > TT (rs368234815), which seems to be a better predictor of spontaneous clearance than the IFNL4 rs12979860 polymorphism...
July 25, 2016: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/27456172/dengue-virus-infection-induces-interferon-lambda1-to-facilitate-cell-migration
#20
Yu-Lin Hsu, Mei-Yi Wang, Ling-Jun Ho, Jenn-Haung Lai
A marked increase in the rate of dengue virus (DENV) infection has resulted in more than 212 deaths in Taiwan since the beginning of 2015, mostly from fatal outcomes such as dengue hemorrhagic fever and dengue shock syndrome. The pathogenic mechanisms of these fatal manifestations are poorly understood. Cytokines induce an overwhelming immune reaction and thus have crucial roles. Interferon-lambda (IFN-λ), a newly identified IFN subtype, has antiviral effects, but its immunologic effects in DENV infection have not been investigated...
2016: Scientific Reports
keyword
keyword
30898
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"